CN106333866B - With anti-dentine hypersensitivity, the high salt composite of whitening function and its toothpaste and preparation method - Google Patents
With anti-dentine hypersensitivity, the high salt composite of whitening function and its toothpaste and preparation method Download PDFInfo
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- CN106333866B CN106333866B CN201610777695.3A CN201610777695A CN106333866B CN 106333866 B CN106333866 B CN 106333866B CN 201610777695 A CN201610777695 A CN 201610777695A CN 106333866 B CN106333866 B CN 106333866B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of high salt composite with anti-dentine hypersensitivity, whitening function, is grouped as by the group of following weight fraction ratio: 4~8 parts of potassium nitrate, 0.1~5 part of pyrophosphate and anti-3~5 parts of sensitive composition of auxiliary；Also disclose application of the high salt composite in toothpaste, tooth powder, tooth gel, tooth paste or ointment preparation；The toothpaste containing this high salt composite is also disclosed, weight percent of the high salt composite in entire toothpaste is 7~11%；It also discloses the preparation method of the toothpaste: moisturizer being added in a reservoir, thickener is added to stir evenly, then sweetener, preservative, surfactant is added and stirs evenly, high salt composite is added, is sufficiently stirred, rubbing agent and water is added, it is stirring evenly and then adding into fragrance regulator, it is sufficiently stirred, vacuum outgas, cream processed is completed.The high salt composite of the present invention and its toothpaste have good whitening antiallergic sense double effects, each ingredient synergistic effect, and effect becomes apparent from.
Description
Technical field
The present invention relates to the oral-cavity articles of antiallergic sense, whitening, and in particular to one kind has anti-dentine hypersensitivity, whitening function
High salt composite and its toothpaste and preparation method.
Background technique
Dentine hypersensitivity is called dental hypersensitiveness, is commonly called as " setting one's teeth on edge ".Due to incorrect method for brushing teeth, undesirable drink
The factors such as dietary habits or age growth, cause the symptoms such as acid etching, enamel abrasion, wedge-shaped defect, gingival recession, eventually lead to tooth
Essence exposure.When tooth encounter it is cold and hot sour-sweet equal or brush teeth equal environmental stimulis when, the of short duration and sharp pain of caused one kind, this
It is exactly dentine hypersensitivity.Be mainly shown as tooth ache, " hair leaching ", breaking-out is rapidly, pain is sharp, the time is of short duration.
Tooth staining refers into bacteriogenic pigment deposition in the external pigment in oral cavity or oral cavity in facing.
Due to smoking, the factors such as the colored drinks such as coffee, tea or age growth are often fed, dental surface can deposit color spot, generate tooth
Stain, bacterial plaque etc., it is serious to will lead to the odontopathies such as calculus dentalis, decayed tooth.If such crowd with dentine hypersensitivity symptom, due to
Tooth stain, bacterial plaque etc. obstruct naturally, and functional component is difficult to through dentinal tubule, then be used alone anti-dentine hypersensitivity toothpaste or its
His therapeutic effect of oral-cavity article is unsatisfactory.
There is document to show potassium ion as desensitizer, mechanism is to act on dentinal tubule, inhibits nerve endings pain
The conduction of signal, thus dentine hypersensitivity pain of releiving；Strontium ion is then used as sealer, and it is small can to block open dentine
Pipe, makes dentine hypersensitivity be eased；The presence of fluorine ion can promote the remineralization of dental surface, play preventing decayed tooth and auxiliary is anti-
The effect of dentine hypersensitivity；Hydroxyapatite is then the main component for constituting tooth, effectively facilitates the remineralization of dental surface simultaneously
Open dentinal tubule is blocked, sensitive teeth can be repaired to a certain degree.Such as using the sylvite of high-content as matrix, with strontium
Salt, fluoride, hydroxyapatite are used in compounding, and can alleviate dentine hypersensitivity pain rapidly, and continuing use can be effectively blocked out
The dentinal tubule put, permanent repair sensitive teeth, because the difference and synergism effect of material and content is also different.
Modern research shows that sodium pyrophosphate has stronger dirt-removing power, meanwhile, it also can reduce the table of surfactant
Face tension plays the role of auxiliary washing.Due to the stability of sodium pyrophosphate be not it is especially desirable, easily such as with alkali metal ion
Calcium, magnesium etc. are complexed and lose activity, and sodium pyrophosphate is easily deliquesced because of water suction in air, and aqueous solution is at 70 DEG C or more
Gradually hydrolyze.So the selection of formulation of tooth-paste system is bad, easily lead to problems such as a point water, lotion thicker.
In toothpaste system, with the increase of total salt content, the colloform texture of thickener for toothpastes occurs greatly to destroy, cream
Body stability, mouthfeel, bubble can vary widely, when the content of potassium nitrate in component reaches 2%-3%, no matter which kind of
The tooth paste product of matrix is likely to occur the bad phenomenons such as a point water, foam are low, mouthfeel is bitter in one week of storage.
Existing patent discloses the toothpaste of potassium nitrate treatment dentine hypersensitivity at present, if patent name is containing sylvite and strontium salt
Antiallergy toothpaste, Authorization Notice No. be CN 100502831C patent document in, describe following content: toothpaste group component
In, it include moisturizer, rubbing agent, adhesive, surfactant, sweetener, fragrance, preservative and water；It is characterized in that: toothpaste group
Point in containing account for entire toothpaste component weight percent be respectively 0.1%~10% strontium salt and account for 0.1%~5% sylvite,
The strontium salt is strontium chloride, and the sylvite is potassium nitrate.
Authorization Notice No. is to describe following content: a kind of toothpaste, feature in the patent document of CN 102670429B
It is: including removing stain active constituent, acid-proof desensitization ingredient and base ingredients；It is described that remove stain active constituent include following quality percentage
The component of ratio: modified sodium phytate 1~10%, hydroxyapatite 1~10%；The acid-proof desensitization ingredient includes following quality percentage
The component of ratio: sodium monofluorophosphate 0.76~0.9% and Chinese medicine desensitizer 0.2~2%；The base ingredients include following quality
The component of percentage: calcium carbonate or aluminium hydroxide 20~50%, silica 1~10%, saccharin sodium 0.2~0.5%, glycerol or
PEG-4002~8%, cellulose gum 0.2~1.3%, xanthan gum 0.2~1.0%, sorbierite 1~40%, essence 1~3%, the moon
Cinnamic alcohol sodium sulfovinate 1~4%.
In the patent document of Authorization Notice No. CN 100536812C, provide it is a kind of treat dentine hypersensitivity have enhancing
Anti-caries and supplement mineral oral cavity composition and method, the composition include be located at oral cavity acceptable carriers in can discharge
The compound of the salt of fluorine ion and the salt that potassium can be discharged.
But there is also following problems for above-mentioned toothpaste: 1. in specific embodiment, has no additive amount higher than 3% potassium nitrate
The embodiment of toothpaste, because the lotion of toothpaste of high content of salt is extremely unstable, it is difficult to implement.2. having no pyrophosphoric acid in the toothpaste
Salt can not thoroughly chelate tooth stain, removal plaque etc., anti-dentine hypersensitivity ingredient can not under the premise of reducing tooth wear
Dentinal tubule is sufficiently acted on, dentine hypersensitivity therapeutic effect is unsatisfactory.3. for dentine hypersensitivity crowd, tooth whitening
It will cause short-term dentine hypersensitivity afterwards, lack necessary anti-dentine hypersensitivity component for treating, it can be to receiving tooth whitening treatment
Patient health impact.
Anti- dentine hypersensitivity effect whitening oral-cavity article outstanding is developed and developed, the new issue of research in recent years is become.
But because recipe ingredient is complicated, lotion is extremely unstable, mouthfeel is not easy to control, commercially available rare to have both anti-dentine hypersensitivity and whitening
The oral-cavity article of function, and synergy of the existing this kind of product in terms for the treatment of dentine hypersensitivity and whitening is unsatisfactory.
Summary of the invention
The object of the present invention is to provide one kind to have effects that anti-dentine hypersensitivity, whitening dual function, with high salt group outstanding
Close object and its toothpaste and preparation method.
The present invention realizes that the technical solution of its purpose is:
A kind of high salt composite with anti-dentine hypersensitivity, whitening dual function, by the component of following weight fraction ratio
Composition: 4~8 parts of potassium nitrate, 0.1~5 part of pyrophosphate and anti-3~5 parts of sensitive composition of auxiliary.
Preferably, the pyrophosphate is sodium pyrophosphate.
Preferably, the anti-sensitive composition of the auxiliary is one of strontium salt, hydroxyapatite or mixture.
Preferably, the strontium salt is strontium chloride.
Preferably, the high salt composite is grouped as by the group of following weight fraction ratio: 5 parts of potassium nitrate, pyrophosphoric acid
1 part of sodium, 3.5 parts of strontium chloride.
A kind of application of above-mentioned high salt composite in toothpaste, tooth powder, tooth gel, tooth paste or ointment preparation.
Application of the high salt composite in toothpaste, tooth powder, tooth gel, tooth paste or ointment preparation, preferably,
The weight percent that the high salt composite accounts for entire component is 7~11%.
A kind of toothpaste with anti-dentine hypersensitivity, whitening function includes rubbing agent, moisturizer, thickener, surface-active
Agent, sweetener, preservative, essence and water also include high salt composite described in above technical scheme, the high salt composite
Weight percent in entire toothpaste is 7~11%.
Preferably, the moisturizer at least contains glycerol, and weight percent of the glycerol in entire toothpaste is 15
~40%；When containing sorbierite in moisturizer, weight percent of the sorbierite in entire toothpaste is no more than 5%.
A kind of preparation method of above-mentioned toothpaste, includes the following steps: that moisturizer is added in a reservoir, adds thickener and stir
It mixes uniformly, sweetener, preservative, surfactant is then added and stirs evenly, add high salt composite, be sufficiently stirred,
Rubbing agent and water is added, is stirring evenly and then adding into fragrance regulator, is sufficiently stirred, vacuum outgas, cream processed is completed.
The beneficial effects of the present invention are: the high salt composite for oral-cavity article of the invention breaches previous desensitizing oral
The low bottleneck of the salt contents such as potassium nitrate in articles, is greatly improved the content of the salt such as potassium nitrate, and the potassium nitrate of high-content plays
The effect of rapid recovery dentine hypersensitivity pain, assists anti-sensitive composition, can effectively block dentinal tubule, effectively repair by
Tooth is damaged, so that it greatly increases the anti-sensitizing effect of tooth；Stain whitening composition is removed in addition in component simultaneously, can be effective
Remove upper teeth stain, bacterial plaque, hence it is evident that improvement cleans the teeth ability, on the one hand plays tooth whitening effect and will not excessive damage tooth
Tooth, on the other hand since the removal of tooth, bacterial plaque allows the preferably through dentinal tubule of anti-sensitive composition, so that antiallergic
Sense ingredient greatly improves the desensitization effect of tooth；The high salt composite has a wide range of application, and can apply to toothpaste, mouthwash, tooth
In other oral-cavity articles such as powder, tooth gel, chewing gum.The toothpaste of the invention containing the high salt composite solves nitric acid simultaneously
The content of potassium reach will appear when 2%-3% divide the bad phenomenons problems such as water, foam are low, mouthfeel is bitter, toothpaste cream obtained
Body stabilization, Wu Fenshui, decoloration, shell, to return bad phenomenons, the commodity property such as thick good.
Detailed description of the invention
Fig. 1 is that 7 days SEM of 8 dentinal tubule plugging effect of experimental group in embodiment 5 observe figure.
Fig. 2 is that 7 days SEM of 10 dentinal tubule plugging effect of experimental group in embodiment 5 observe figure.
Specific embodiment
Below with reference to embodiment, the invention will be further described, but not thereby limiting the invention.
Experimental method in following embodiments is unless otherwise instructed conventional method.
Embodiment 1 has the high salt composite of anti-dentine hypersensitivity, whitening function
High salt composite with anti-dentine hypersensitivity, whitening function, is grouped as: nitric acid by the group of following weight fraction ratio
4~8 parts of potassium, 0.1~5 part of sodium pyrophosphate and auxiliary it is anti-3~5 parts of sensitive composition, the anti-sensitive composition of the auxiliary be strontium chloride,
One of hydroxyapatite or a variety of mixtures.
Embodiment 2 has the high salt composite of anti-dentine hypersensitivity, whitening function
High salt composite with anti-dentine hypersensitivity, whitening function, is grouped as: nitric acid by the group of following weight fraction ratio
5~7 parts of potassium, 1~4 part of sodium pyrophosphate and anti-3~5 parts of sensitive composition of auxiliary, the anti-sensitive composition of the auxiliary is strontium chloride, hydroxyl
One of base apatite or a variety of mixtures.
Embodiment 3 has the high salt composite of anti-dentine hypersensitivity, whitening function
High salt composite with anti-dentine hypersensitivity, whitening function, is grouped as: nitric acid by the group of following weight fraction ratio
5 parts of potassium, 1 part of sodium pyrophosphate, 3.5 parts of strontium chloride.
High salt composite of the invention can be applied in toothpaste, tooth powder, tooth gel, tooth paste or ointment preparation,
With anti-dentine hypersensitivity, whitening function.
Embodiment 4 has the toothpaste of anti-dentine hypersensitivity, whitening function
Toothpaste is prepared in accordance with the following steps: moisturizer being added in a reservoir, is added thickener and is stirred evenly, is then added
Sweetener, preservative, surfactant simultaneously stir evenly, and add any high salt composite in embodiment 1-3, sufficiently
Stirring is added rubbing agent and water, is stirring evenly and then adding into essence, is sufficiently stirred, and vacuum outgas, cream processed is completed.Each component quality
Percentage are as follows:
Any high salt composite in embodiment 1-3,7~18%, preferably 9~16%.
It is single that polyethylene glycol, glycerol, sorbierite, propylene glycol etc. can be used in moisturizer 10~70%, preferably 20~40%
Or mixtures thereof one.
Rubbing agent 10~60%, preferably 20~50%；Calcium carbonate, silica, calcium monohydrogen phosphate, glycerol phosphorus can be used
Sour calcium etc..
Thickener 0.1%~10%, preferably 0.5~2%；Can be used sodium carboxymethylcellulose, hydroxyethyl cellulose,
Xanthan gum, carrageenan, guar gum, carbomer etc. are or mixtures thereof single.
Surfactant 0.1~20%, preferably 0.1~3%；Amino acid surfactant, dodecane can be used
Base sodium sulphate etc. is single or it is mixed.
Sweetener 0.1%~2%, preferably 0.1~0.5%；Can be used saccharin, saccharin sodium, Aspartame, neotame,
Sucralose etc..
Essence 0.1~5%, preferably 0.1~1.5%；Peppermint, spearmint oil, American mint, anethole can be used
Deng.
Preservative ratio 0.1~0.5%, it is a kind of in sodium benzoate, parabens and its sodium salt, potassium sorbate or
A variety of mixtures.
Surplus is water.
The measure of merit of toothpaste of the embodiment 5 containing high salt composite
The toothpaste of experimental group 1-5,7-10 is prepared, (component ratio is quality to specific formula in the present embodiment as shown in table 1
Percentage), it operates in accordance with the following steps: (1) glycerol being added in Manufacturing medicine extract machine；(2) sodium carboxymethylcellulose is added to stir evenly；
(3) saccharin sodium, sodium benzoate, lauryl sodium sulfate is added and is uniformly mixed；(4) potassium nitrate, strontium chloride and hydroxyl phosphorus is added
Lime stone, sodium pyrophosphate, are sufficiently stirred；(5) silica and water is added, stirs evenly；(6) essence is added, is sufficiently stirred；(7)
Vacuum outgas, cream processed are completed.
Experimental group 1-5,7-8 is the toothpaste added with high-content salt composite；Experimental group 9 is to contain high proportion potassium nitrate, chlorine
Change strontium, but the toothpaste without sodium pyrophosphate, hydroxyapatite；Experimental group 10 is the toothpaste of general content salt composite.
19 groups of formulation of tooth-paste of table
Measure of merit is carried out to toothpaste made from experimental group 1-5,7-10:
Test the 1 quick antiallergic sense Clinical efficacy containing high salt composite toothpaste
One, experimental method
1. subject is to meet to be included in and the healthy adult male and women of exclusion criteria.Totally 82 meet and are included in exclusion item
The subject of part has participated in this research, wherein 79 are completed final research.
2. being included in standard: subject is between 18-70 years old, and whole body health is in order；Subject must have at least two positions
Sensitive teeth before grinding one's teeth in sleep, has neck to wear away or wear or gingival recession, visits when baseline checks and examines sensitive scoring in 10-
30g (Yeaple probe) and/or cold air stimulate count value >=2；Other similar research is not participated in simultaneously；Before participating in research
3 months without using desensitizing toothpaste；It is ready to sign informed consent form, inspection can be participated at any time during test.
Two, experimental result
Sensitivity assessment summary is examined in the spy of table 2
3 cold air of table blows and sprays sensitivity assessment summary
Compare conclusion: by table 2,3 as it can be seen that experimental group 2 is compared with experimental group 10, either using product at once still three days
After evaluate, the spy of experimental group 2 examine sensitivity indices or cold air hang down basin sensitivity indices have with experimental group 10 it is statistically significant
Sex differernce, it was demonstrated that there is apparent quickly antiallergic sense effect containing high salt composite toothpaste experimental group 10 toothpaste low compared to salt content
Fruit.
Test the 2 antiallergic sense Clinical efficacies containing high salt composite toothpaste
One, experimental method
1. subject is to meet to be included in and the healthy adult male and women of exclusion criteria.Totally 100 meet and are included in exclusion
The subject of condition has participated in this research, wherein 87 are completed final research.
2. being included in standard: subject is between 18-70 years old, and whole body health is in order；Subject must have at least two positions
Sensitive teeth before grinding one's teeth in sleep, has neck to wear away or wear or gingival recession, visits when baseline checks and examines sensitive scoring in 10-
30g (Yeaple probe) and/or cold air stimulate count value >=2；Other similar research is not participated in simultaneously；Before participating in research
3 months without using desensitizing toothpaste；It is ready to sign informed consent form, inspection can be participated at any time during test.
Two, experimental result
Sensitivity assessment summary is examined in the spy of table 4
5 cold air of table blows and sprays sensitivity assessment summary
By table 4,5 as it can be seen that experimental group 1 is compared with experimental group 9, was either still evaluated, tested after 8 weeks using product 4 weeks
Sensitivity indices or the vertical basin sensitivity indices of cold air are examined in the spy of group 1 has statistical significant difference with experimental group 9, it was demonstrated that contains
There is the toothpaste of pyrophosphate relative to the toothpaste for being free of pyrophosphate, confrontation dentine hypersensitivity effect is more preferable, and pyrophosphate is to nitre
Sour potassium, strontium chloride desensitization effect have collaboration facilitation.
Test plugging effect SEM paired observation of 3 toothpaste containing high salt composite to dentinal tubule
By Fig. 1,2 as it can be seen that experimental group 8 is compared with experimental group 10, after continuous use 7 days, in the case where amplification factor is 2000 times
Observation, experimental group 8 are substantially better than experimental group 10 to the plugging effect of dentinal tubule, it was demonstrated that the anti-tooth containing high salt composite toothpaste
Essential sensitizing effect is significantly better than the toothpaste of general content salt composite.
The clinical observation of the removal exogenous color spot of tooth containing high salt composite toothpaste of experiment 4
1.77 subjects complete the research of whole (4 weeks with 8 weeks).Share 13 subjects (No. 17, toothpaste, No. 2
6, toothpaste) it is excluded halfway, data are not included in statistical analysis.Subject is unrelated with this research the reason of midway excludes.
2. being included in standard: the age is between 18~70 years old；Whole body health is in order；It can be with during 8 weeks of test
When participate in inspection；There are 12 natural labial teeths, and the dummies such as the filling without large area or hat in mouthful；Tooth has exogenous color spot to deposit
?；It is ready to participate in test and has signed letter of consent.
The color spot index mean of 6 70 subject's baselines of table and the 4th weekly check compares
The color spot index mean of 7 70 subject's baselines of table and the 8th weekly check compares
By table 6,7 as it can be seen that experimental group 2 is compared with experimental group 7, be either using being evaluated after product 4 weeks or 8 weeks,
There is significant decrease on the area and degree statistical analysis of the exogenous color spot of facing, it was demonstrated that not only have containing high salt composite toothpaste
Have a whitening effect, and its anti-dentine hypersensitivity effect is better than the toothpaste without pyrophosphate and hydroxyapatite, pyrophosphate and
Hydroxyapatite, which fights dentine hypersensitivity, has collaboration facilitation effect.
Test 5 stability observings containing high salt composite toothpaste
Under conditions of room temperature and 45 DEG C, stability observing, experimental result such as table 8 are carried out respectively to experimental group 1-5,7-10
It is shown.According to the observation of experimental group 10 as a result, the toothpaste of general salt content uses the moisturizing system of full sorbierite, that is, it can guarantee cream
External appearance quality is stablized.Comparative experiments group 4,5,7,9 is it is found that be more than 5% when sorbierite accounts for the percentage of entire lotion total weight
When, lotion tends to be unstable with the increase of sorbitol content；And pyrophosphate can play the role of water lock, but with storage
The increase of time, in the system experimental group 5,7 that sorbierite is compounded with glycerol, pyrophosphate can be hydrolyzed, and lotion is being stored
Divide water at 2-3 months.Each experimental group is compared it is found that when sorbierite accounts for the percentage of entire lotion total weight lower than 5%,
Lotion quality containing high salt composite toothpaste is stablized.
8 experimental group 1-10 stability observing of table record
Claims (4)
1. a kind of toothpaste with anti-dentine hypersensitivity, whitening function includes rubbing agent, moisturizer, thickener, surface-active
Agent, sweetener, preservative, essence and water, which is characterized in that include also high salt composite, the high salt composite by weighing as follows
The group of amount portion rate is grouped as: 4~8 parts of potassium nitrate, 0.1~5 part of pyrophosphate and anti-3~5 parts of sensitive composition of auxiliary, described
Assisting anti-sensitive composition is one of strontium salt, hydroxyapatite or mixture, and the high salt composite is in entire toothpaste
Weight percent is 7~11%, and the moisturizer at least contains glycerol, and weight percent of the glycerol in entire toothpaste is 15
~40%；When containing sorbierite in moisturizer, weight percent of the sorbierite in entire toothpaste is no more than 5%.
2. toothpaste as described in claim 1, which is characterized in that the pyrophosphate is sodium pyrophosphate.
3. toothpaste as described in claim 1, which is characterized in that the strontium salt is strontium chloride.
4. a kind of preparation method of the described in any item toothpaste of claims 1 to 3, which comprises the steps of: holding
Moisturizer is added in device, adds thickener and stirs evenly, sweetener, preservative, surfactant is then added and stirs equal
It is even, high salt composite is added, is sufficiently stirred, rubbing agent and water is added, is stirring evenly and then adding into essence, is sufficiently stirred, vacuum
Degassing, cream processed are completed.
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| CN106880554A (en) * | 2017-03-14 | 2017-06-23 | 四川蓝伯特生物科技股份有限公司 | A kind of sweet wormwood toothpaste and preparation method thereof |
| CN107374990A (en) * | 2017-08-03 | 2017-11-24 | 吕天宽 | The composition and its tooth powder and preparation method of a kind of anti-sensitivity of tooth |
| CN107669498A (en) * | 2017-10-13 | 2018-02-09 | 吕天宽 | The composition and its tooth powder and preparation method of a kind of anti-sensitivity of tooth |
| CN112826751B (en) * | 2021-01-28 | 2022-07-22 | 重庆登康口腔护理用品股份有限公司 | Anti-allergy toothpaste capable of enhancing fluorine activity |
| CN112870146A (en) * | 2021-02-08 | 2021-06-01 | 许耿防 | Toothpaste for resisting dentin sensitivity |
| CN113633558B (en) * | 2021-09-07 | 2022-09-23 | 重庆登康口腔护理用品股份有限公司 | Composition with good biocompatibility and application thereof in oral products |
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| WO2002045679A2 (en) * | 2000-11-08 | 2002-06-13 | Colgate-Palmolive Company | Desensitizing dual component dentifrice |
| CN1528260A (en) * | 2003-09-30 | 2004-09-15 | 重庆登康口腔护理用品股份有限公司 | Double antianaphylaxis tooth paste containing sylvine and strontium salt |
| CN101829026A (en) * | 2010-05-11 | 2010-09-15 | 李少君 | Composition for clearing tooth stains |
| CN104352368A (en) * | 2014-09-30 | 2015-02-18 | 青岛叁鼎卫生制品有限公司 | Acid-proof and antibacterial multi-effect toothpaste |
| CN105055223A (en) * | 2015-08-10 | 2015-11-18 | 庄立 | Traditional Chinese medicine toothpaste capable of stopping bleeding and desensitizing |
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| CN106333866A (en) | 2017-01-18 |
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