CN107669498A - The composition and its tooth powder and preparation method of a kind of anti-sensitivity of tooth - Google Patents
The composition and its tooth powder and preparation method of a kind of anti-sensitivity of tooth Download PDFInfo
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- CN107669498A CN107669498A CN201710956379.7A CN201710956379A CN107669498A CN 107669498 A CN107669498 A CN 107669498A CN 201710956379 A CN201710956379 A CN 201710956379A CN 107669498 A CN107669498 A CN 107669498A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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Abstract
The invention discloses a kind of composition of anti-sensitivity of tooth, it is made up of the component of following mass percent:Alkali metal salt provides agent 20%~98%, anti-sensitive composition 0.02%~8%;Also disclose application of the said composition in tooth powder, tooth paste or ointment preparation;The tooth powder containing said composition is also disclosed, the mass percent that said composition accounts for whole tooth powder is 20%~98%;Also disclose tealeaves account for whole tooth powder mass percent be 0.1%~40%;Also disclose Tea Polyphenols account for whole tooth powder mass percent be 0.1%~40%;Also disclose lubricant account for whole tooth powder mass percent be 0.1%~50%;Also disclose said composition and the preparation method of the tooth powder containing said composition;Tooth paste or ointment preparation containing the component are also disclosed, the mass percent that said composition accounts for respective whole components is 10%~80%;The said composition and its tooth powder of the present invention has good anti-sensitivity of tooth effect.
Description
Technical field
The present invention relates to a kind of composition and its tooth powder and preparation method of the oral care product that can resist sensitivity of tooth,
Belong to oral care implement field.
Background technology
Sensitivity of tooth, also known as sensitivity of tooth, are called dental hypersensitiveness, resident with advancing age, due to various
Factor causes the symptoms such as acid etching, enamel abrasion, wedge-shaped defect, gingival atrophy, when tooth runs into cold and hot sour-sweet grade or extraneous thorn
When swashing, cause of short duration and sharp discomfort or pain, it is serious to show as that tooth is aching and limp powerless, and here it is sensitivity of tooth.
With advancing age, the aching and limp powerless symptom of tooth, and the common disease of mouth disease occurs in groups of people to resident
One of shape.
With advancing age, dental surface can deposit bacterial plaque etc. to resident, and serious meeting causes calculus dentalis or even decayed tooth, this
Class crowd is easier that sensitivity of tooth occurs.
It is at present material of strontium chloride and the sylvite such as potassium nitrate as anti-sensitivity of tooth generally using strontium salt.
Potassium and sodium belong to alkali metal, have same or analogous physicochemical properties, and sylvite has anti-sensitivity of tooth
Effect, sodium salt also have the function that anti-sensitivity of tooth.Sodium ion and potassium ion maintain osmotic pressure during human metabolism, are people
The important element of body metabolism.
Alkali metal salt sodium sulphate is referred to as the compound of glauber-salt and liquorice in traditional Chinese medicine, is anhydrous sodium sulfate;Saltcake is the sodium sulphate containing the crystallization water,
There is detumescence of relieving inflammation or internal heat, for controlling abscess of throat, aphthae, swelling and aching of gum etc. outside, sodium sulphate is one kind in sodium salt.
Calcirm-fluoride, fluorapatite are the important substances of dental mineralization, promote tooth mineralising again, to treating and preventing carious tooth
There is effect, also have effect to tooth antiallergic sense.Fluoride can promote dental surface remineralization with calcium binding, can block and open
The dentinal tubule put, continue, using can effectively block open dentinal tubule, to reach the purpose of permanent repair sensitive teeth.
Toothpaste with fluoride is widely used in China and in the world.
Water-soluble Ca salt generates monofluorophosphoric acid calcium with soluble fluoride such as mono-fluor phosphate in water or in saliva, swims
From monofluorophosphoric acid calcium molecule can adsorb on tooth surfaces, promote dental mineralization again.
Soluble fluoride and water-soluble Ca salt in aqueous/saliva in reaction generation such as calcirm-fluoride, fluorapatite
Indissoluble material, and soluble fluoride and water-soluble Ca salt can not be contained in toothpaste simultaneously.
Tealeaves contains Tea Polyphenols, refreshing and detoxicating, there are some researches show Tea Polyphenols can alleviate oral inflammation, has to gum reparation
Play the role of good.
In the A of application publication number CN 106309209 patent document, content is described below:A kind of tooth protective cleaning is protected
Strong product, raw material and mass ratio are:Orange peel 3~10%, Equisetum hiemale Linne 5~15%, desmodium 3~8%, exquisite salt 3~10% are green
Tea 10~20%, folium artemisiae argyi ash 10~20%, caryophyllus oil 5~15%, calcium carbonate 20~30%, xylitol 15~20%, lauryl alcohol
Sodium sulphate 1~3%, carboxymethyl cellulose 3~5%, potassium sorbate 1~5%, by orange peel, green tea, Equisetum hiemale Linne, desmodium system
Into nanometer grade powder, above-mentioned powder stock is well mixed with other raw materials toothpaste is made.
In the open A of notification number CN 106333866 patent document, content is described below:One kind have anti-sensitivity of tooth,
The high salt composite of whitening function, it is characterised in that be made up of the component of following ratio of weight and number:4~8 parts of potassium nitrate, burnt phosphorus
0.1~5 part of hydrochlorate and anti-3~5 parts of the sensitive composition of auxiliary.It is strontium salt, fluoride or hydroxyapatite to aid in anti-sensitive composition
In one or more mixtures, fluoride is sodium fluoride or sodium monofluorophosphate or stannous fluoride.It is characterized in that the height
The percentage by weight that salt composite accounts for whole component is 7~18%.Described high salt composite toothpaste, tooth powder, tooth gel,
Application in tooth paste or ointment preparation.
In the A of Authorization Notice No. CN 101123939 patent document, content is described below:Oral care composition, including
Xylitol and water-soluble calcium salt, wherein described big xylitol and the calcium salt exist with least about 10: 1 weight ratio.
Water-soluble calcium salt is selected from:Calcium chloride, calcium acetate, calcium butyrate, calcium citrate, calcium lactate, calcium salicylate, calcium glycerophosphate,
And its mixture.Agent is provided including fluoride, wherein it is sodium monofluorophosphate that the fluoride, which provides agent,.Wherein described fluoride carries
Be enough to provide about 200ppm to 3000ppm fluoride ions for amount existing for agent, the fluoride provide agent with about 0.001% to
About 3% weight is present in the composition.Wherein described oral care composition is selected from:Mouthwass, collutory, liquid
Tooth agent, tooth film, gear rack, gel paint, tooth bead, sweet food, lozenge, natural gum, toothpaste, tooth gel, tooth latex and tooth powder.
In the A of application publication number CN 106619189 patent document, content is described below:The present invention is a kind of sea salt tooth
Cream, it is characterised in that be made up of the raw material of following weight parts:Sodium chloride 10~24, sea salt 10~14.5, hydroxyethyl cellulose
0.20~1.5, cataloid 1.5~3.0, glycerine 4.0~8.0, oxirane, propylene oxide block copolymer 0.2~
0.8th, Arizona bacilli 26~35, saccharin 0.08~0.5, Purified Water 35~45, the present invention with the addition of sea salt composition, can be well
Tooth and anti-inflammation are cleaned, the symptoms such as oral peculiar smell and halitosis, significant effect can be relaxed well.
The content of the invention
It is an object of the present invention to provide one kind to have anti-sensitivity of tooth, has the composition and its tooth powder and system of good effects
Preparation Method.
The present invention realizes that its purpose technical scheme is:
A kind of composition with anti-sensitivity of tooth, is made up of the component of following mass percent:Alkali metal salt provides agent
20%~98%, anti-sensitive composition 0.02%~8% is aided in, aids in anti-sensitive composition to provide agent by calcium salt and fluoride and forms.
Alkali metal salt provides agent:
Said composition includes alkali metal salt and provides agent.Alkali metal salt, which provides agent, has enough water solubilitys with water or saliva
Middle release sodium ion and/or potassium ion.Suitable alkali metal provides agent and provides agent for inorganic or organic alkali metal salt.
Inorganic alkaline metal salt provide agent include sodium chloride, sodium bromide, sodium iodide, sodium hypochlorite, sodium chlorate, sodium perchlorate,
Sodium hypobromite, sodium bromate, hyperbromic acid sodium, hypoiodous acid sodium, sodium iodate, sodium metaperiodate, sodium nitrate, natrium nitrosum, sodium sulphate, burnt sulphur
Sour sodium, sodium sulfite, sodium pyrosulfite, sodium thiosulfate, sodium sulfocyanate, yellow sodium prussiate, vulcanized sodium, NaHS, sodium carbonate,
Sodium acid carbonate, sodium phosphate, dibastic sodium phosphate, sodium dihydrogen phosphate, sodium pyrophosphate, the hydrogen trisodium of pyrophosphoric acid one, Sodium Acid Pyrophosphate, Jiao
Tricresyl phosphate hydrogen sodium, sodium hypophosphite, Boratex, sodium tripolyphosphate, sodium molybdate, sodium manganate, sodium permanganate, sodium chromate, sodium dichromate,
Sodium bismuthate, natrium cobaltinitrosum, sodium tungstate, sodium hydroxide, potassium chloride, KBr, KI, postassium hypochlorite, potassium chlorate, perchloric acid
Potassium, potassium hypobromite, potassium bromate, hyperbromic acid potassium, hypoiodous acid potassium, Potassiumiodate, potassium metaperiodate, potassium nitrate, potassium nitrite, potassium sulfate,
Potassium pyrosulfate, potassium sulfite, potassium metabisulfite, potassium thiosulfate, potassium rhodanide, yellow potassium prussiate, potassium sulfide, potassium bisulfide, carbon
Sour potassium, saleratus, potassium phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate, potassium pyrophosphate, the hydrogen tripotassium of pyrophosphoric acid one, pyrophosphoric acid dihydro two
Potassium, the hydrogen potassium of pyrophosphoric acid three, potassium hypophosphite, potassium hydroxide, potassium borate, PTPP, potassium molybdate, potassium manganate, potassium permanganate, chromium
Sour potassium, potassium bichromate, bismuthic acid potassium, cobalt potassium nitrite, potassium tungstate and its mixture.
Preferably, inorganic alkaline metal salt is soluble and remains soluble in water or saliva, preferable inorganic alkaline metal salt
Offer agent is sodium chloride, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, potassium sulfate and its mixture.
Organic acid alkali metal salt has certain corrosion function to tooth.Organic alkali metal salt provide agent include saccharin sodium,
Sodium glutamate, sodium formate, sodium acetate, sodium propionate, sodium butyrate, natrium valericum, sodium n-caproate, sodium caprate, Sodium Caprylate, adipic acid sodium, second
Diacid sodium, sodium malonate, sodium succinate, sodium maleate, sodium tartrate, sodium phenylacetate, sodium phthalate, terephthalic acid (TPA)
Sodium, odium stearate, sodium palmitate, PAA, sodium citrate, sodium lactate, sodium salicylate, sodium glycero-phosphate, sodium gallate,
It is sodium benzoate, natrium malicum, sodium hyaluronate, sodium gluconate, sodium vedproate, sodium sulfonate, sulfinic acid sodium, sodium citrate, anti-bad
Hematic acid sodium, sodium caffeate, enuatrol, linoleic acid sodium, leukotrienes sodium, maleic acid sodium, M-phthalic acid sodium, terephthalic acid (TPA)
Sodium, sodium phthalate, sodium succinate, tartaric acid sodium, Sodium p-aminobenzene sulfonat, chlorosulfonic acid sodium, hydroxyl sulfoacid sodium, isopropyl sulfonic acid
Sodium, sodium sorbate, sodium tannate, inositol sodium hexametaphosphate, sodiumphenoxyacetate, morpholino b acid sodium, 3- (N- morpholines) third sulphur
Sour sodium, 3- (cyclohexylamine) -1- propanesulfonates, 4- hydroxyethyl piperazineethanesulfonic acids sodium, 2- chloroethyls sodium sulfonate, 2- (diethanol amido)
Double (the 2- hydroxyl second of ethyl sulfonic acid sodium, N- (2- acetamidos) -2- iminodiacetic acid sodiums, N- carbamoyl methyl ethyl sulfonic acids sodium, 3-
Base) amino -2- hydroxypropionate sodiums, 3- amino -1- propane sulfonic acids sodium, 2- cyclohexylamino ethyl sulfonic acids sodium, ethoxy imino-diacetic
Double (the 2- of sodium acetate, 3- (cyclohexylamine) -2- hydroxyl -1- propanesulfonates, 2- [[three (methylol) methyl] amino] ethyl sulfonic acid sodium, 3-
Ethoxy) amino -2- hydroxypropionate sodiums, N- (2- ethoxys) piperazine-N '-(2- hydroxy-propanesulfonic acids) sodium, new-nucleo, hexichol
Amine sodium sulfonate, dehydroactic acid sodium, P-hydroxybenzoic acid sodium, potassium saccharin, benzene sulfinic acid sodium salt, sodium N-lauroyl sarcosinate, laruyl alcohol
Sodium sulphate, sodium alginate, sodium naphthalene sulfonate, sodium naphthalene sulfonate, sodium carboxymethylcellulose, acesulfame sodium, potassium glutamate, formic acid
Potassium, potassium acetate, potassium propionate, potassium butyrate, valeric acid potassium, caproic acid potassium, Capric acid potassium salt, potassium octanoate, Potassium Adipate, ethanedioic acid potassium, malonic acid
It is potassium, potassium succinate, maleic acid potassium, potassium tartrate, phenylacetic acid potassium, phthalic acid potassium, potassium terephthalate, potassium stearate, soft
Resin acid potassium, potassium acrylate, potassium citrate, potassium lactate, potassium salicylate, potassium glycerinophosphate, gallic acid potassium, Potassium Benzoate, apple
Sour potassium, potassium hyaluronate, K-IAO, valproic acid potassium, potassium sulfonate, sulfinic acid potassium, Monopotassium citrate, potassium ascorbate, caffeic acid
Potassium, potassium oleate, linoleic acid potassium, leukotrienes potassium, maleic acid potassium, M-phthalic acid potassium, potassium terephthalate, phthalic acid
Potassium, Potassium Suceinate, tartaric acid potassium, aminobenzenesulfonic acid potassium, chlorosulfonic acid potassium, hydroxyl sulfoacid potassium, isopropyl sulfonic acid potassium, potassium sorbate, pellet
Peaceful sour potassium, the potassium phosphate of inositol six, phenoxy acetic acid potassium, morpholino b acid potassium, 3- (N- morpholines) propane sulfonic acid potassium, 3- (hexamethylenes
Amine) -1- propane sulfonic acid potassium, 4- hydroxyethyl piperazineethanesulfonic acids potassium, 2- chloroethyls potassium sulfonate, 2- (diethanol amido) ethyl sulfonic acid potassium, N-
Double (2- ethoxys) amino -2- hydroxyls of (2- acetamidos) -2- iminodiacetic acids potassium, N- carbamoyl methyl ethyl sulfonic acids potassium, 3-
Base propane sulfonic acid potassium, 3- amino -1- propane sulfonic acids potassium, 2- cyclohexylamino ethyl sulfonic acids potassium, hydroxyethyliminodiacetic acid potassium, 3- (rings
Hexylamine) -2- hydroxyl -1- propane sulfonic acid potassium, 2- [[three (methylol) methyl] amino] ethyl sulfonic acid potassium, double (2- ethoxys) amino of 3- -
2- hydroxy-propanesulfonic acids potassium, N- (2- ethoxys) piperazine-N '-(2- hydroxy-propanesulfonic acids) potassium, nucleotides potassium, diphenylamine sulfonic acid potassium, benzene
Sulfinic acid potassium, lauroyl sarcosine potassium, laruyl alcohol potassium sulfate, dehydroactic acid potassium, P-hydroxybenzoic acid potassium, potassium alginate, naphthalene
Potassium sulfonate, potassium carboxymethylcellulose, acesulfame potassium and its mixture.
Preferably, it is sodium chloride, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, sulphur that the alkali metal salt, which provides agent,
Sour potassium and its mixture, its mass percent are 20%~98%.
Calcium salt:
The calcium salt that said composition includes includes calcium propionate, calcium nitrite, calcium sulfate, calcium sulfite, calcium thiosulfate, oxidation
Calcium, calcium bromide, calcium iodide, calcium hypochlorite, calcium chlorate, Calcium perchlorate, calcium bromate, calcium iodate, calcium sulfide, calcium sulfhydrate, sulphur cyanogen
Sour calcium, calcium carbonate, calcium bicarbonate, calcium phosphate, calcium dihydrogen phosphate, calcium monohydrogen phosphate, tripolyphosphate calcium, hexa metaphosphoric acid calcium, pyrophosphoric acid
Calcium, calcium hypophosphite, artificial schellite, calcium gluconate, Calcium Ascorbate, calcium benzoate, calcium octoate, calcium caseinate, sulfomethylated lignin
Sour calcium, calcium cyclamate, calcium glutamate, calcium fumarate, calcium lactobionate, calcium laurate, calcium pantothenate, phytic acid
Calcium (phytic acid calcium), calcium sorbate, calcium benzosulphimide, beta-hydroxy-Beta-methyl calcium butyrate, HMB calcium, calcium acrylate,
Methacrylic acid calcium, isobutyric acid calcium and its mixture.
The calcium salt that said composition includes also includes above-mentioned calcium salt and its mixture, with calcium chloride, calcium nitrate, calcium acetate, fourth
Sour calcium, calcium citrate, calcium lactate, calcium salicylate, the mixture of calcium glycerophosphate any combination.
Preferably, water-soluble calcium salt is soluble and remains soluble in water or saliva, preferable described calcium salt
For calcium benzosulphimide, its mass percent is 0.01%~5%.
Fluoride provides agent:
Said composition includes fluoride and provides agent or fluoride ion source.It is known anti-caries agent that fluoride, which provides agent,.Fluorine
Compound, which provides agent, has enough water-soluble fluoride ions with the release anti-caries amount in water or saliva.Suitable fluoride carries
For agent agent is provided for inorganic or organic fluoride.
Inorganic fluoride ion, which provides agent, includes metal, alkali metal, alkaline-earth metal and the ammonium salt of fluoride, such as is fluorinated
Sodium, potassium fluoride, ammonium acid fluoride, calcirm-fluoride, copper fluoride such as copper fluoride, barium fluoride, prodan, ammonium fluosilicate, fluorine zirconic acid
Sodium, sodium monofluorophosphate and difluorophosphoric acid aluminium, fluorinated sodium calcium pyrophosphate, stannous fluoride, lithium fluoride, cesium fluoride, aluminum fluoride, fluorination
Copper, indium, fluorine zirconic acid stannous, ferric flouride, fluorination palladium, silver fluoride, zirconium fluoride and its mixture.Preferably, it is described inorganic
It is sodium monofluorophosphate that fluoride ion, which provides agent,.
Organic fluoride ion, which provides agent, includes hydrofluorination ethamine, laurylamine hydrofluoride, hydrofluorination tetradecylamine, hydrogen fluorine
Change decyl alcohol amine, hydrofluorination oleyl amine, hydrofluorination tetradecane oxygen amine, diethyllaminoethyl decoyl amine hydrofluoride, diethanol
Amino-ethyl oleyl amides hydrofluoride, diethanolamino propyl group-N '-oleyl amine dihydrofluoride, 1- ethanol -2- ten
Six base rice oxazoline dihydrofluorides, glycine betaine hydrofluoride, sarcosine stannous fluoride, alanine stannous fluoride, glycine fluorination
Potassium, sarcosine potassium, glycine hydrofluoride, lysine hydrofluoride, alanine hydride, glycine betaine zirconium fluoride and its
Mixture.
Preferably, water-soluble fluoride offer agent is soluble and remains soluble in water or saliva, preferable institute
It is sodium monofluorophosphate that the fluoride stated, which provides agent, and its mass percent is 0.01%~3%.
A kind of application of above-mentioned composition in tooth powder
Application of the said composition in tooth powder, preferably, the mass percent that the composition accounts for whole components is
20%~98%.
A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, surfactant, sweetener, Tea Polyphenols, also include
Composition described in above technical scheme, mass percent of the composition in tooth powder are 20%~98%.
Preferably, mass percent of the described Tea Polyphenols in tooth powder is 0.1%~40%.
A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, surfactant, sweetener, tealeaves, also include with
Composition described in upper technical scheme, mass percent of the composition in tooth powder are 20%~98%.
Described tealeaves be black tea, green tea, white tea, black tea, Partial fermentation tea, preferably green tea, its quality in tooth powder
Percentage is 0.1%~40%.
A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, surfactant, sweetener, Tea Polyphenols, lubricant,
Also include the composition described in above technical scheme, mass percent of the composition in tooth powder is 20%~98%.
Preferably, mass percent of the described Tea Polyphenols in tooth powder is 0.1%~40%.
Described lubricant is sorb (sugar) alcohol, polyethylene glycol 400, Macrogol 600, Macrogol 4000, poly- second two
Alcohol 6000, PEG 8000, PEG20000 and its mixture.
Preferably, described lubricant is Macrogol 4000, its mass percent in tooth powder be 0.1%~
50%.
A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, surfactant, sweetener, tealeaves, lubricant, also
Include the composition described in above technical scheme, mass percent of the composition in tooth powder is 20%~98%.
Described tealeaves be black tea, green tea, white tea, black tea, Partial fermentation tea, preferably green tea, its quality in tooth powder
Percentage is 0.1%~40%.
Described lubricant is sorb (sugar) alcohol, polyethylene glycol 400, Macrogol 600, Macrogol 4000, poly- second two
Alcohol 6000, PEG 8000, PEG20000 and its mixture.
Preferably, described lubricant is Macrogol 4000, its mass percent in tooth powder be 0.1%~
50%.
Application of the said composition in tooth gel, paste, ointment preparation, preferably, the composition accounts for whole
The mass percent of component is 10%~80%.
A kind of preparation method of above-mentioned tooth powder, comprises the following steps:By tealeaves or Tea Polyphenols, rubbing agent, surfactant,
Sweetener, the composition 20%~98% for also including anti-sensitivity of tooth, are respectively prepared powder, by every kind of content no more than 10%
Component is first uniformly mixed in a reservoir, and then remaining component is put into the container and is stirred for being mixed
Thing, sieving, screenings are finished product tooth powder, and prepared by tooth powder completes.
A kind of preparation method of above-mentioned tooth powder, comprises the following steps:By tealeaves or Tea Polyphenols, rubbing agent, surfactant,
Lubricant, sweetener, the composition 20%~98% for also including anti-sensitivity of tooth, are respectively prepared powder, and every kind of content is little
Component in 10% is first uniformly mixed in a reservoir, and then remaining component is put into the container and is stirred for being well mixed
Mixture is obtained, is sieved, screenings is finished product tooth powder, and prepared by tooth powder completes.
The beneficial effects of the invention are as follows:The composition for oral care of the present invention breaches alkali in conventional oral-cavity article
The low bottleneck of the salt content such as metal salt such as potassium nitrate, the content of alkali metal salt, the alkali metal salt energy of high content is greatly improved
Play a part of rapid recovery sensitivity of tooth pain, the fluorapatite molecule for aiding in anti-sensitive composition to generate in use can be inhaled
It is attached on tooth, effectively repairs impaired tooth, enhances the effect of anti-sensitivity of tooth, then add in the tooth powder containing said composition
Enter Tea Polyphenols or tealeaves, have good effect to alleviating gum discomfort, while clean oral cavity, remove oral peculiar smell, inhibiting bacteria and diminishing inflammation
There is good effect.
Embodiment
With reference to embodiment, the invention will be further described, but not thereby limiting the invention.
Experimental method in following embodiments, it is conventional method unless otherwise instructed.
Embodiment 1 has the composition of anti-sensitivity of tooth.
Embodiment 1 has the composition of anti-sensitivity of tooth, is made up of the component of following mass percent:Optional alkali metal
A kind of such as sodium nitrate in salt sodium chloride, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, potassium sulfate, sodium nitrate 20%~98%,
Anti- sensitive composition 0.02%~8% is aided in, the anti-sensitive composition of described auxiliary is calcium benzosulphimide, sodium monofluorophosphate.
Embodiment 2 has the composition of anti-sensitivity of tooth.
Embodiment 2 has the composition of anti-sensitivity of tooth, is made up of the component of following mass percent:Optional alkali metal
Two kinds of such as sodium chloride and potassium nitrate in salt sodium chloride, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, potassium sulfate, both group
Point both mass percent sums be 20%~98%, wherein sodium chloride 0.1%~97.9%, potassium nitrate 0.1%~
97.9%th, anti-sensitive composition 0.02%~8% is aided in, the anti-sensitive composition of described auxiliary is calcium benzosulphimide, sodium monofluorophosphate.
Embodiment 3 has the composition of anti-sensitivity of tooth.
Embodiment 3 has the composition of anti-sensitivity of tooth, is made up of the component of following mass percent:Optional alkali metal
Three kinds of such as potassium chloride, sodium nitrate and potassium sulfates in salt sodium chloride, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, potassium sulfate, chlorine
Change potassium, sodium nitrate and potassium sulfate, person's mass percent sum of these three components is 20%~98%, wherein potassium chloride 0.1%
~97.8%, sodium nitrate 0.1%~97.8%, potassium sulfate 0.1%~97.8%, the anti-sensitive composition 0.02%~8% of auxiliary, institute
The anti-sensitive composition of auxiliary stated is calcium benzosulphimide, sodium monofluorophosphate.
Embodiment 4 has the composition of anti-sensitivity of tooth.
Embodiment 4 has the composition of anti-sensitivity of tooth, is made up of the component of following mass percent:Optional alkali metal
Four kinds such as sodium chloride, sodium sulphate, potassium nitrate and sulphur in salt sodium chloride, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, potassium sulfate
Sour potassium, the mass percent sum of this four components is 20%~98%, wherein sodium chloride 0.1%~97.7%, sodium sulphate
0.1%~97.7%, potassium nitrate 0.1%~97.7%, potassium sulfate 0.1%~97.7%, the anti-sensitive composition 0.02% of auxiliary~
8%, the anti-sensitive composition of described auxiliary is calcium benzosulphimide, sodium monofluorophosphate.
Embodiment 5 has the composition of anti-sensitivity of tooth.
Embodiment 5 has the composition of anti-sensitivity of tooth, is made up of the component of following mass percent:Optional alkali metal
Five kinds such as sodium chloride, sodium nitrate, sodium sulphate, nitre in salt sodium chloride, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, potassium sulfate
Sour potassium and potassium sulfate, the mass percent sum of this five components are 20%~98%, wherein sodium chloride 0.1%~97.6%,
Sodium nitrate 0.1%~97.6%, sodium sulphate 0.1%~97.6%, potassium nitrate 0.1%~97.6%, potassium sulfate 0.1%~
97.6%th, anti-sensitive composition 0.02%~8% is aided in, the anti-sensitive composition of described auxiliary is calcium benzosulphimide, sodium monofluorophosphate.
Embodiment 6 has the composition of anti-sensitivity of tooth.
Embodiment 6 has the composition of anti-sensitivity of tooth, is made up of the component of following mass percent:Alkali metal salt chlorine
Change sodium, sodium nitrate, sodium sulphate, potassium chloride, potassium nitrate, potassium sulfate, the mass percent sum of this six components for 20%~
98%, wherein sodium chloride 0.1%~97.5%, sodium nitrate 0.1%~97.5%, sodium sulphate 0.1%~97.5%, potassium chloride
0.1%~97.5%, potassium nitrate 0.1%~97.5%, potassium sulfate 0.1%~97.5%, the anti-sensitive composition 0.02% of auxiliary~
8%, the anti-sensitive composition of described auxiliary is calcium benzosulphimide, sodium monofluorophosphate.
The composition of the present invention can be applied in tooth powder, tooth gel, tooth paste or ointment preparation, have anti-tooth
Sensitization.
Embodiment 7 has the tooth powder of anti-sensitivity of tooth
Embodiment 7 prepares tooth powder in accordance with the following steps:Granularity is made in tealeaves and is not more than 0.045 millimeter of (325 mesh) powder,
Granularity is made in rubbing agent and is not more than 0.011 millimeter of (1300 mesh) powder, surfactant, sweetener and described anti-tooth
The powder that granularity is not more than 0.250 millimeter (60 mesh) is respectively prepared in the sensitive composition of tooth, by every kind of content no more than 10%
Component is first uniformly mixed in a reservoir, and then remaining component is put into the container and is stirred for being mixed
Thing, mixture cross 60 mesh sieves, and screenings is finished product tooth powder, and prepared by tooth powder completes.
Embodiment 8 has the tooth powder of anti-sensitivity of tooth
Embodiment 8 prepares tooth powder in accordance with the following steps:Granularity is made in rubbing agent and is not more than 0.011 millimeter of (1300 mesh) powder
Granularity is respectively prepared no more than 0.250 in end, surfactant, Tea Polyphenols, the composition of sweetener and described anti-sensitivity of tooth
The powder of millimeter (60 mesh), component of every kind of content no more than 10% is first uniformly mixed in a reservoir, then residue
Component be put into the container be stirred for it is well mixed obtain mixture, mixture crosses 60 mesh sieves, and screenings is finished product tooth powder,
Prepared by tooth powder completes.
Embodiment 9 has the tooth powder of anti-sensitivity of tooth
Embodiment 9 prepares tooth powder in accordance with the following steps:Granularity is made in tealeaves and is not more than 0.045 millimeter of (325 mesh) powder,
Granularity is made in rubbing agent and is not more than 0.011 millimeter of (1300 mesh) powder, surfactant, sweetener, lubricant and institute
The powder that granularity is not more than 0.250 millimeter (60 mesh) is respectively prepared in the composition for the anti-sensitivity of tooth stated, and every kind of content is little
Component in 10% is first uniformly mixed in a reservoir, and then remaining component is put into the container and is stirred for being well mixed
Mixture is obtained, mixture crosses 60 mesh sieves, and screenings is finished product tooth powder, and prepared by tooth powder completes.
Embodiment 10 has the tooth powder of anti-sensitivity of tooth
Embodiment 10 prepares tooth powder in accordance with the following steps:Granularity is made in rubbing agent and is not more than 0.011 millimeter (1300 mesh)
Granularity is respectively prepared not in powder, surfactant, Tea Polyphenols, sweetener, the composition of lubricant and described anti-sensitivity of tooth
More than the powder of 0.250 millimeter (60 mesh), component of every kind of content no more than 10% is first uniformly mixed in a reservoir, so
Remaining component is put into the container afterwards to be stirred for being well mixed and obtains mixture, mixture crosses 60 mesh sieves, and screenings is
Finished product tooth powder, prepared by tooth powder completes.
The mass percent of embodiment 7-10 each components:
The composition of any described anti-sensitivity of tooth, 20%~98%, preferably 40%~89% in embodiment 7-10.
Rubbing agent 0~30%, preferably 0~20% in embodiment 7-10, silicate hydrate, silica, hydrogen can be used
Aluminum oxide, calcium monohydrogen phosphate, calcium carbonate etc..
Tealeaves described in embodiment 7 and embodiment 9 is green tea 0.1%~40%, preferably 4%~20%.
Tea Polyphenols 0.1%~40% described in embodiment 8 and embodiment 10, preferably 2%~20%.
Surfactant 0.1%~10%, preferably 0.1%~3% in embodiment 7-10, laruyl alcohol sulfuric acid can be used
Sodium, amino acid surfactant etc. are single or it is mixed.
Sweetener 0.1%~5%, preferably 1%~4% in embodiment 7-10, neotame, Abbas's sweet tea, saccharin can be used
Sodium etc..
Lubricant 0.1%~50%, preferably 3%~25% in embodiment 9-10, described lubricant are polyethylene glycol
4000。
Claims (10)
1. a kind of composition with anti-dentine hypersensitivity, it is characterised in that be made up of the component of following mass percent:Alkali gold
Belong to salt and agent 20%~98%, the anti-sensitive composition 0.02%~8% of auxiliary are provided.
2. alkali metal salt as claimed in claim 1 provides agent, it is characterised in that selected from sodium chloride, sodium nitrate, sodium sulphate, chlorination
Potassium, potassium nitrate, potassium sulfate.
3. anti-sensitive composition is aided in provide agent for calcium salt, fluoride as claimed in claim 1, it is characterised in that the calcium salt is
Calcium benzosulphimide, it is sodium monofluorophosphate that described fluoride, which provides agent,.
4. anti-sensitive composition is aided in as claimed in claim 1, it is characterised in that be made up of the component of following mass percent:Chlorine
Change calcium 0.01%~5%, sodium monofluorophosphate 0.01%~3%.
A kind of 5. application of the composition as described in 1 to 4 any one as described in right 1 in tooth powder.
6. a kind of tooth powder with anti-sensitivity of tooth, comprising Tea Polyphenols, rubbing agent, surfactant, sweetener, its feature exists
In also including the composition described in claim any one of 1-4, mass percent of the composition in whole tooth powder is
20%~98%;Mass percent of the described Tea Polyphenols in whole tooth powder is 0.1%~40%.
7. a kind of tooth powder with anti-sensitivity of tooth, includes tealeaves, rubbing agent, surfactant, sweetener, it is characterised in that
Also include the composition described in claim any one of 1-4, mass percent of the composition in whole tooth powder is
20%~98%;Mass percent of the described tealeaves in whole tooth powder is 0.1%~40%.
8. a kind of tooth powder with anti-sensitivity of tooth, comprising Tea Polyphenols, rubbing agent, surfactant, lubricant, sweetener, its
It is characterised by, also includes the composition described in claim any one of 1-4, quality hundred of the composition in whole tooth powder
Divide than being 20%~98%;Mass percent of the described Tea Polyphenols in whole tooth powder is 0.1%~40%;Described profit
Lubrication prescription is Macrogol 4000, and its mass percent in tooth powder is 0.1%~50%.
9. a kind of tooth powder with anti-sensitivity of tooth, comprising tealeaves, rubbing agent, surfactant, lubricant, sweetener, it is special
Sign is, also includes the composition described in claim any one of 1-4, quality percentage of the composition in whole tooth powder
Than for 20%~98%;Mass percent of the described tealeaves in whole tooth powder is 0.1%~40%;Described lubricant is
Macrogol 4000, its mass percent in tooth powder are 0.1%~50%.
10. application of the composition as described in claim any one of 1-4 in tooth gel, paste or ointment preparation, it is special
Sign is that the mass percent that the composition accounts for respective whole components is 10%~80%.
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Cited By (1)
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