CN101829026A - Composition for clearing tooth stains - Google Patents
Composition for clearing tooth stains Download PDFInfo
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- CN101829026A CN101829026A CN 201010173231 CN201010173231A CN101829026A CN 101829026 A CN101829026 A CN 101829026A CN 201010173231 CN201010173231 CN 201010173231 CN 201010173231 A CN201010173231 A CN 201010173231A CN 101829026 A CN101829026 A CN 101829026A
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- sodium
- composition
- deionized water
- Prior art date
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Links
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000003381 stabilizer Substances 0.000 claims abstract description 11
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000811 xylitol Substances 0.000 claims abstract description 10
- 235000010447 xylitol Nutrition 0.000 claims abstract description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 10
- 229960002675 xylitol Drugs 0.000 claims abstract description 10
- 239000000084 colloidal system Substances 0.000 claims abstract description 9
- 239000000043 antiallergic agent Substances 0.000 claims abstract description 8
- 239000000080 wetting agent Substances 0.000 claims abstract description 8
- 239000001301 oxygen Substances 0.000 claims abstract description 7
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 7
- 239000000126 substance Substances 0.000 claims abstract description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 25
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 150000002978 peroxides Chemical class 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- 235000019264 food flavour enhancer Nutrition 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 229960001631 carbomer Drugs 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 6
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 5
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 5
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 5
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 5
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 5
- 229940045872 sodium percarbonate Drugs 0.000 claims description 5
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 5
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 5
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 4
- 108010011485 Aspartame Proteins 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 claims description 4
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- MMCOUVMKNAHQOY-UHFFFAOYSA-N carbonoperoxoic acid Chemical compound OOC(O)=O MMCOUVMKNAHQOY-UHFFFAOYSA-N 0.000 claims description 4
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 229960002900 methylcellulose Drugs 0.000 claims description 4
- 235000010981 methylcellulose Nutrition 0.000 claims description 4
- 239000005543 nano-size silicon particle Substances 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 229920001983 poloxamer Polymers 0.000 claims description 4
- 229960000502 poloxamer Drugs 0.000 claims description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 4
- 239000011775 sodium fluoride Substances 0.000 claims description 4
- 235000013024 sodium fluoride Nutrition 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 235000010333 potassium nitrate Nutrition 0.000 claims description 3
- 239000004323 potassium nitrate Substances 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 244000246386 Mentha pulegium Species 0.000 claims description 2
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 2
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 2
- 239000004376 Sucralose Substances 0.000 claims description 2
- 208000002925 dental caries Diseases 0.000 claims description 2
- 235000001050 hortel pimenta Nutrition 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 229950008882 polysorbate Drugs 0.000 claims description 2
- 239000011698 potassium fluoride Substances 0.000 claims description 2
- 235000003270 potassium fluoride Nutrition 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 2
- 229940013553 strontium chloride Drugs 0.000 claims description 2
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 2
- 235000019408 sucralose Nutrition 0.000 claims description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 abstract description 14
- 238000002360 preparation method Methods 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 3
- -1 pH adjustor Substances 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 2
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 230000008859 change Effects 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 5
- 230000002087 whitening effect Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a composition for clearing tooth stains, which belongs to the technical field of oral health preparation products. The composition comprises substance capable of generating oxygen radicals, substance capable of forming gel or colloid, stabilizer, pH adjustor, wetting agent, anti-allergic agent, xylitol, flavoring agent and deionized water; and the appearance shape of the composition is gel or colloid. The composition for clearing the tooth stains has the advantages of stable property, difficult decomposition and liquefaction and long-term storage at the normal temperature, and is convenient to store, transport and use, so the composition can be operated and used not only by professional doctors in dental clinics and but also by patients at home.
Description
Technical field
The invention belongs to the preparing technical field of oral cavity health preparation, particularly relating to a kind of is effective ingredient with the peroxide, is carrier with non-Newtonian fluid such as gel or Newtonian fluid such as colloid, is used to remove the compositions of teeth stains.
Background technology
Current society, people more and more pay close attention to the oral hygiene of oneself with healthy, have the pure white tooth of a bite more to become the target that many people pursue.Since U.S. odontologist in 1981 was used to hydrogen peroxide to remove teeth stains for the first time, peroxide was cleared into branch with the standard mottle that its obvious effects and safety become dental clinic.Yet directly using peroxide not only user's tooth and gingiva to be produced stimulates, but also can because action time the short mottle that causes remove not exclusively, so a lot of researchs are being done aspect the peroxide effectiveness improving by various countries research institution.Wherein studying maximum is to select for use suitable carriers to prolong the time of peroxide contact dental surface.This wherein have adopt thin film do carrier as " Methods for whitening teeth " (United States Patent (USP) 7,122,199), " Strip for whitening tooth surfaces " (United States Patent (USP) 6,514,483), have adopt colloid or gel be carrier as " Tooth whitening hydrogels " (United States Patent (USP) 6,746,679), " Tooth whitening composition " (United States Patent (USP) 6,419,905).With colloid or gel is that the mottle of carrier is removed compositions and removed mottle comprehensively, advantages such as user's oral stimulation is little have been obtained the favor of dental clinic with it, and becomes its standard teeth stains and remove preparation.But because the unstability of peroxide in colloid or gel, the effective ingredient meeting oneself's within a short period of time decompose, and can't satisfy the time demand of circulation, accumulating, sale, uses thereby make it can only be confined to dental clinic, can't come into huge numbers of families.Therefore, expectation provides a kind of compositions that teeth stains is removed that is used for of stable performance, its effective ingredient can the oneself not decompose within a certain period of time, thereby satisfy the time demand of circulation, accumulating, sale, reach and just be not confined to use in the clinic, and can really enter huge numbers of families, satisfy daily family needs.
Summary of the invention
The compositions that is used to remove teeth stains that the purpose of this invention is to provide a kind of stable in properties, said composition comprise the material that can produce oxygen-derived free radicals, can form gel or colloidal material, stabilizing agent, pH value regulator and deionized water; Its mode of appearance is gel or colloid.The using method of said composition: directly be coated onto it on tooth or be coated onto on the dens supporter, then dens supporter is applied on the tooth.
The concrete component and the percentage by weight of the compositions that is used to remove teeth stains provided by the invention are as follows:
1) material that can produce oxygen-derived free radicals of 3%-50%, preferred 5%-30%, this material is a peroxide, is specially in hydrogen peroxide, percarbamide, SODIUM PERCARBONATE, the percarbonic acid calcium one or more;
2) 0.2%-20%'s can form gel or colloidal material, preferred 0.5%-10%, this material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, xanthan gum, the arabic gum;
3) stabilizing agent of 0.05%-5%, preferred 0.1%-2%, be used to protect the chemical property of composition system and stablizing of form, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
4) the pH value regulator of 0.1%-5%, preferred 0.2%-2%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5) deionized water, surplus are deionized water.
The compound method of compositions of the present invention: earlier with said components 2) be dissolved in the deionized water, then with component 3) dissolve in the adding system, add component 4 at last) and regulate pH value, stir and promptly get the compositions that is used to remove teeth stains.
Compositions provided by the invention can also be added wetting agent, anti-allergic agent, xylitol and flavour enhancer; Each weight percentages of components of adding after these components is:
The material that can produce oxygen-derived free radicals of 1.3%-50%, preferred 5%-30%, this material is a peroxide, is specially in hydrogen peroxide, percarbamide, SODIUM PERCARBONATE, the percarbonic acid calcium one or more;
2.0.2%-20% can form gel or colloidal material, preferred 0.5%-10%, this material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, xanthan gum, the arabic gum;
3.0.05%-5% stabilizing agent, preferred 0.1%-2%, be used to protect the chemical property of composition system and stablizing of form, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
4.0.1%-5% pH value regulator, preferred 0.2%-2%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5.0.5%-10% wetting agent, preferred 1-5%, wetting agent is a surfactant, is specially in glycerol, Polyethylene Glycol, polysorbate, the tween one or more;
6.0.05%-5% anti-allergic agent, preferred 0.1%-2%, anti-allergic agent is one or more in sodium fluoride, potassium fluoride, strontium chloride, sodium monofluorophosphate, the potassium nitrate;
7.0.2%-10% xylitol, preferred 1%-5% adds xylitol and helps the compositions caries prevention;
8.0.02%-2% flavour enhancer, preferred 0.1%-1% is used to regulate the mouthfeel of compositions, and flavour enhancer is one or more in Mentholum, peppermint essence, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
9. deionized water, surplus is a deionized water.
The compound method of the compositions of the removing teeth stains of interpolation wetting agent, anti-allergic agent, xylitol and flavour enhancer component is: earlier said components 2 is dissolved in the deionized water, to dissolve in other material adding system except that component 4 then, add component 4 at last and regulate pH value, stir and promptly get the compositions that is used to remove teeth stains.
With technology arranged now compare, the compositions of removing teeth stains provided by the invention has stable in properties, be difficult for decomposing and liquefaction, but the advantage of room temperature long preservation, and be convenient to accumulating, using method is easy, therefore compositions of the present invention no longer is confined to and can only be manipulated by specialist in dental clinic, also patient oneself manipulates at home, satisfy daily family needs, remove the trouble that the patient must go to a doctor repeatedly from.
The specific embodiment
Following non-limiting example is further narrated the preferred embodiment in the scope of the invention.In the case without departing from the scope of the present invention, a lot of variations of present embodiment are possible.
Embodiment 1
Weight percentages of components (%)
Hydrogen peroxide 8.00
Carbomer 4.00
Sodium dihydrogen phosphate 0.30
Polyethylene Glycol 2.00
Sodium fluoride 1.00
Xylitol 1.00
Aspartame 0.08
Fructus Citri Limoniae essence 0.15
Sodium hydroxide 0.85
Deionized water 82.62
Compound method: earlier carbomer is dissolved in the deionized water, will dissolves in other material adding system except that sodium hydroxide then, add sodium hydroxide at last and stir and promptly get the compositions that can be used for removing teeth stains.The said composition of preparation is a gel form.
Embodiment 2
Weight percentages of components (%)
Percarbamide 25.00
Polyvinylpyrrolidone 8.50
Tetrasodium pyrophosphate 0.24
EDTA disodium 0.10
Glycerol 4.00
Xylitol 5.0
Potassium nitrate 5.00
Sodium fluoride 0.15
Saccharin sodium 0.05
Fructus Citri Limoniae essence 0.15
Triethanolamine 1.57
Deionized water 50.24
Compound method: earlier polyvinylpyrrolidone is dissolved in the deionized water, will dissolves in other material adding system except that triethanolamine then, add triethanolamine at last and stir and promptly get the compositions that can be used for removing teeth stains.The said composition of preparation is the colloid form.
Embodiment 3
Weight percentages of components (%)
SODIUM PERCARBONATE 13.00
Carboxymethyl cellulose 4.00
EDTA disodium 0.30
Tween 2.00
Sodium monofluorophosphate 1.00
Aspartame 0.08
Fructus Citri Limoniae essence 0.15
Stevioside 0.10
Sodium carbonate 2.00
Deionized water 77.37
Compound method: earlier carboxymethyl cellulose is dissolved in the deionized water, will dissolves in other material adding system except that sodium hydroxide then, add sodium hydroxide at last and stir and promptly get the compositions that can be used for removing teeth stains.The said composition of preparation is a gel form.
Embodiment 1-3 composition prepared is compared with purchasing in the sample of dental clinic, storage at normal temperature 12 months, during the observation sample mode of appearance change and measure active o content.
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Dental clinic's sample | |
| 3 months | No change | No change | No change | No change |
| 5 months | No change | No change | No change | Volumetric expansion is to original 50% |
| 8 months | No change | No change | No change | Volumetric expansion is to original 100% |
| 12 months | Gel outward appearance no change, active o content reduces by 4% | Gel outward appearance no change, active o content reduces by 4% | Gel outward appearance no change, active o content reduces by 3% | Solation can't use |
Claims (6)
1. a compositions of removing teeth stains is characterized in that, described compositions comprises the material that can produce oxygen-derived free radicals, can form gel or colloidal material, stabilizing agent, pH value regulator and deionized water; Its mode of appearance is gel or colloid.
2. a kind of compositions of removing teeth stains according to claim 1 is characterized in that, the concrete component and the percentage by weight of said composition are as follows:
1) material that can produce oxygen-derived free radicals of 3%-50%, preferred 5%-30%, this material is a peroxide, is specially in hydrogen peroxide, percarbamide, SODIUM PERCARBONATE, the percarbonic acid calcium one or more;
2) 0.2%-20%'s can form gel or colloidal material, preferred 0.5%-10%, this material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, xanthan gum, the arabic gum;
3) stabilizing agent of 0.05%-5%, preferred 0.1%-2%, be used to protect the chemical property of composition system and stablizing of form, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
4) the pH value regulator of 0.1%-5%, preferred 0.2%-2%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5) deionized water, surplus are deionized water.
3. prepare the described a kind of method for compositions of removing teeth stains of claim 2, it is characterized in that, its concrete grammar is: earlier with the component in the claim 2 2) be dissolved in the deionized water, then with component 3) dissolve in the adding system, add component 4 at last) regulate pH value, stir and promptly get the compositions that is used to remove teeth stains.
4. a kind of compositions of removing teeth stains according to claim 1 is characterized in that said composition also contains wetting agent, anti-allergic agent, xylitol and flavour enhancer.
5. a kind of compositions of removing teeth stains according to claim 3 is characterized in that, the concrete component and the percentage by weight of described compositions are as follows:
1) material that can produce oxygen-derived free radicals of 3%-50%, preferred 5%-30%, this material is a peroxide, is specially in hydrogen peroxide, percarbamide, SODIUM PERCARBONATE, the percarbonic acid calcium one or more;
2) 0.2%-20%'s can form gel or colloidal material, preferred 0.5%-10%, this material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, xanthan gum, the arabic gum;
3) stabilizing agent of 0.05%-5%, preferred 0.1%-2%, be used to protect the chemical property of composition system and stablizing of form, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
4) the pH value regulator of 0.1%-5%, preferred 0.2%-2%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5) wetting agent of 0.5%-10%, preferred 1-5%, wetting agent is a surfactant, is specially in glycerol, Polyethylene Glycol, polysorbate, the tween one or more;
6) anti-allergic agent of 0.05%-5%, preferred 0.1%-2%, anti-allergic agent is one or more in sodium fluoride, potassium fluoride, strontium chloride, sodium monofluorophosphate, the potassium nitrate;
7) xylitol of 0.2%-10%, preferred 1%-5% adds xylitol and helps the compositions caries prevention;
8) flavour enhancer of 0.02%-2%, preferred 0.1%-1% is used to regulate the mouthfeel of compositions, and flavour enhancer is one or more in Mentholum, peppermint essence, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
9) deionized water, surplus are deionized water.
6. prepare the described a kind of method for compositions of removing teeth stains of claim 5, it is characterized in that, its concrete grammar is: earlier with the component in the claim 5 2) be dissolved in the deionized water, then will be except that component 4) other material adding system in dissolve, add component 4 at last) regulate pH value, stir and promptly get the compositions that is used to remove teeth stains.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101732314A CN101829026B (en) | 2010-05-11 | 2010-05-11 | Composition for clearing tooth stains |
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| CN2010101732314A CN101829026B (en) | 2010-05-11 | 2010-05-11 | Composition for clearing tooth stains |
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| Publication Number | Publication Date |
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| CN101829026A true CN101829026A (en) | 2010-09-15 |
| CN101829026B CN101829026B (en) | 2012-07-04 |
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| CN2010101732314A Expired - Fee Related CN101829026B (en) | 2010-05-11 | 2010-05-11 | Composition for clearing tooth stains |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416002A (en) * | 2011-11-23 | 2012-04-18 | 南京泽恒医药技术开发有限公司 | Composition for precursor gel type fluoride chewing tablet |
| CN106333866A (en) * | 2016-08-31 | 2017-01-18 | 重庆登康口腔护理用品股份有限公司 | High-salinity composition having functions of resisting dentine hypersensitivity and whitening, toothpaste and preparation method of toothpaste |
| CN106344432A (en) * | 2016-11-07 | 2017-01-25 | 长沙蒽俏蔓生物科技有限公司 | Tooth whitening gel and preparation method and application thereof |
| CN106668063A (en) * | 2017-02-13 | 2017-05-17 | 郑州呀可宁医用设备有限公司 | Desensitization hemostatic gel and preparation method thereof |
| CN107260580A (en) * | 2012-12-14 | 2017-10-20 | 高露洁-棕榄公司 | Oral care composition for dental whitening |
| CN108348409A (en) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | Dentifrice composition with improved fluoride stability |
| CN114129466A (en) * | 2021-11-11 | 2022-03-04 | 扬州美星口腔护理用品有限公司 | Novel whitening tooth paste |
| CN115634160A (en) * | 2022-10-20 | 2023-01-24 | 克劳丽化妆品股份有限公司 | Tooth whitening composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1499955A (en) * | 2001-04-04 | 2004-05-26 | Kits for whitening teeth | |
| CN1691934A (en) * | 2002-10-31 | 2005-11-02 | 卡德伯里亚当斯美国有限责任公司 | Compositions for removing stains from dental surfaces and methods of making and using the same |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1499955A (en) * | 2001-04-04 | 2004-05-26 | Kits for whitening teeth | |
| CN1691934A (en) * | 2002-10-31 | 2005-11-02 | 卡德伯里亚当斯美国有限责任公司 | Compositions for removing stains from dental surfaces and methods of making and using the same |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416002A (en) * | 2011-11-23 | 2012-04-18 | 南京泽恒医药技术开发有限公司 | Composition for precursor gel type fluoride chewing tablet |
| CN107260580A (en) * | 2012-12-14 | 2017-10-20 | 高露洁-棕榄公司 | Oral care composition for dental whitening |
| CN107260580B (en) * | 2012-12-14 | 2021-04-27 | 高露洁-棕榄公司 | Oral care composition for tooth whitening |
| CN108348409A (en) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | Dentifrice composition with improved fluoride stability |
| CN106333866A (en) * | 2016-08-31 | 2017-01-18 | 重庆登康口腔护理用品股份有限公司 | High-salinity composition having functions of resisting dentine hypersensitivity and whitening, toothpaste and preparation method of toothpaste |
| CN106333866B (en) * | 2016-08-31 | 2019-08-06 | 重庆登康口腔护理用品股份有限公司 | With anti-dentine hypersensitivity, the high salt composite of whitening function and its toothpaste and preparation method |
| CN106344432A (en) * | 2016-11-07 | 2017-01-25 | 长沙蒽俏蔓生物科技有限公司 | Tooth whitening gel and preparation method and application thereof |
| CN106668063A (en) * | 2017-02-13 | 2017-05-17 | 郑州呀可宁医用设备有限公司 | Desensitization hemostatic gel and preparation method thereof |
| CN114129466A (en) * | 2021-11-11 | 2022-03-04 | 扬州美星口腔护理用品有限公司 | Novel whitening tooth paste |
| CN115634160A (en) * | 2022-10-20 | 2023-01-24 | 克劳丽化妆品股份有限公司 | Tooth whitening composition and preparation method thereof |
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|---|---|
| CN101829026B (en) | 2012-07-04 |
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Effective date of registration: 20210628 Address after: 276100 Baichang village, Lizhuang Town, Tancheng County, Linyi City, Shandong Province Patentee after: SHANDONG JIANRONG TEACHING EQUIPMENT CO.,LTD. Address before: 100085 Xipin Technology (Beijing) Co.,Ltd., Building 528, Building D, No. 2 Shangdi Information Road, Haidian District, Beijing Patentee before: Li Shaojun |
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