CN106490600A - A kind of Herba Dendrobii compound tablet, injection, electuary - Google Patents
A kind of Herba Dendrobii compound tablet, injection, electuary Download PDFInfo
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- CN106490600A CN106490600A CN201610881007.8A CN201610881007A CN106490600A CN 106490600 A CN106490600 A CN 106490600A CN 201610881007 A CN201610881007 A CN 201610881007A CN 106490600 A CN106490600 A CN 106490600A
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 23
- 238000002347 injection Methods 0.000 title claims abstract description 7
- 239000007924 injection Substances 0.000 title claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 61
- 239000000243 solution Substances 0.000 claims abstract description 31
- 241000192656 Nostoc Species 0.000 claims abstract description 17
- 239000000284 extract Substances 0.000 claims abstract description 17
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 15
- 239000008176 lyophilized powder Substances 0.000 claims abstract description 15
- 229940096421 milk thistle extract Drugs 0.000 claims abstract description 14
- 235000020727 milk thistle extract Nutrition 0.000 claims abstract description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 12
- 240000007817 Olea europaea Species 0.000 claims abstract description 9
- 235000002725 Olea europaea Nutrition 0.000 claims abstract description 9
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 8
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 8
- 241000169546 Lycium ruthenicum Species 0.000 claims abstract description 8
- 241000628997 Flos Species 0.000 claims abstract description 7
- 240000006927 Foeniculum vulgare Species 0.000 claims abstract description 7
- 235000004204 Foeniculum vulgare Nutrition 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000009636 Huang Qi Substances 0.000 claims abstract description 6
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 6
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 6
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 6
- 235000008434 ginseng Nutrition 0.000 claims abstract description 6
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 6
- 239000011718 vitamin C Substances 0.000 claims abstract description 6
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract 2
- 238000004880 explosion Methods 0.000 claims description 29
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 12
- 239000006228 supernatant Substances 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 7
- 108091005804 Peptidases Proteins 0.000 claims description 6
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- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
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- 229920005989 resin Polymers 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 108090000145 Bacillolysin Proteins 0.000 claims description 5
- 102000035092 Neutral proteases Human genes 0.000 claims description 5
- 108091005507 Neutral proteases Proteins 0.000 claims description 5
- 238000000855 fermentation Methods 0.000 claims description 5
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- 230000007062 hydrolysis Effects 0.000 claims description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 241000186226 Corynebacterium glutamicum Species 0.000 claims description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 3
- 241000320380 Silybum Species 0.000 claims description 3
- 235000010841 Silybum marianum Nutrition 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 238000013461 design Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000003480 eluent Substances 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000011081 inoculation Methods 0.000 claims description 3
- 239000002054 inoculum Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
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- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 241000194108 Bacillus licheniformis Species 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 244000294611 Punica granatum Species 0.000 claims 1
- 235000014360 Punica granatum Nutrition 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 230000036039 immunity Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
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- 235000013376 functional food Nutrition 0.000 description 6
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- 238000011161 development Methods 0.000 description 4
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- 230000006872 improvement Effects 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 241000779819 Syncarpia glomulifera Species 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
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- 239000001739 pinus spp. Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229940036248 turpentine Drugs 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 101710180313 Protease 3 Proteins 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
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- 210000000988 bone and bone Anatomy 0.000 description 1
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- 210000000232 gallbladder Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of Herba Dendrobii compound tablet, injection, electuary, the electuary is prepared from by the raw material of following weight portion：30 40 parts of Herba Dendrobii lyophilized powder, 10 20 parts of Olive leaf P.E, 10 15 parts of Milk Thistle extract, 10 15 parts of vitamin C, 10 20 parts of Radix Panacis Quinquefolii powder, 58 parts of Arillus Longan powder, 10 20 parts of hemsley rockvine root extracting solution, 5 10 parts of Sucus Zingberis, 5 10 parts of Fructus Crataegi powder, 35 parts of fennel powder, 36 parts of Flos Chrysanthemi powder, 59 parts of Lycium ruthenicum Murr. extract, 10 15 parts of Nostoc yeast powder, 5 10 parts of Radix Ginseng, 5 10 parts of the Radix Astragali.The present invention is with homemade Herba Dendrobii lyophilized powder as main component, the interpolation of collaboration Olive leaf P.E, hemsley rockvine root extracting solution, Nostoc yeast powder etc., the immunity of human body can be significantly improved, concrete preferably blood circulation promoting and blood stasis dispelling, effect of supplementing QI and nourishing YIN, and cause eater to be difficult to get angry.
Description
Technical field
The present invention relates to field of health care products, and in particular to a kind of Herba Dendrobii compound tablet, injection, electuary.
Background technology
With society and economic progress, the improvement of people's living standards, the development of science and technology, the change of disease pattern
And the pursuit to having good health and a long life, the functional food of enhancing immunity gradually deep people's popular feeling, people are had started to from treating again
Turn to and prevent again, this will be greatly promoted the development of the functional food of enhancing immunity.21 century will be that functional food is big
The century that displays one's abilities.China has the huge treasure-house of Chinese herbal medicine this functional food and other characteristic resources, and we should combine
The functional food development trend of enhancing immunity and the impetus of China's development, make great efforts to excavate these precious resources, develop
The functional food of enhancing immunity with Chinese characteristics, to obtain due status in fierce international competition.
According to historical document and modern study it is experimentally confirmed that effect for oral administration of Herba Dendrobii mainly has：Yin-nourishing and body fluid promoting maintenance five
Dirty, health invigorating, enhance immunity, strengthening the tendons and bones, opposing rheumatism, strengthen the spleen and stomach, function of gallbladder promoting, control liver and gall diseases, prevent and treat diabetes,
Suppress tumor, reduce Radiotherapy chemotherapy side effect, item eye protection, and moisturizing skin moistening, life lengthening etc..
Content of the invention
For solving the above problems, the invention provides a kind of Herba Dendrobii compound tablet, injection, electuary, with homemade iron sheet stone
Dry measure used in former times lyophilized powder is main component, cooperates with the interpolation of Olive leaf P.E, hemsley rockvine root extracting solution, Nostoc yeast powder etc., energy
The enough significant immunity for improving human body；By Milk Thistle extract, Lycium ruthenicum Murr. extract, Fructus Crataegi powder, fennel powder, Flos Chrysanthemi
The synergism of powder, Radix Panacis Quinquefolii powder etc., concrete preferably blood circulation promoting and blood stasis dispelling, effect of supplementing QI and nourishing YIN, and eater is difficult
Fire.
For achieving the above object, the technical scheme taken of the present invention is：
A kind of Herba Dendrobii compound granules, are prepared from by the raw material of following weight portion：
Herba Dendrobii lyophilized powder 30-40 parts, Olive leaf P.E 10-20 parts, Milk Thistle extract 10-15 parts, vitamin C
10-15 parts, Radix Panacis Quinquefolii powder 10-20 parts, Arillus Longan powder 5-8 parts, hemsley rockvine root extracting solution 10-20 parts, Sucus Zingberis 5-10 parts, Fructus Crataegi powder
5-10 parts, fennel powder 3-5 part, Flos Chrysanthemi powder 3-6 parts, Lycium ruthenicum Murr. extract 5-9 parts, Nostoc yeast powder 10-15 parts, Radix Ginseng 5-
10 parts, Radix Astragali 5-10 parts.
Preferably, the Herba Dendrobii lyophilized powder prepares gained by following steps：
S1, the Herba Dendrobii that drains will be cleaned it is placed in steam-explosion jar, it is 0.6- to be first passed through nitrogen to steam explosion pressure inside the tank
1.4MPa, explosion treatment 8-25min；Then it is 1.4-1.8MPa to be passed through rapidly steam to steam explosion pressure inside the tank, at steam explosion
After reason 0.5-2.5min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrated solution, obtains powder body；
S2, in powder body add 3-8 times of water, by mass percentage be 2-3% ratio add neutral protease, by quality
Percentage ratio is that 1-2% adds flavor protease, digests 1-2h, filter, obtain enzymolysis solution at 30-50 DEG C；
S3, by naturally to thaw again after the fermentation liquid quick freeze of gained, make age of starch precipitation in extract；Collect supernatant
Liquid, remainder are centrifuged, and collect centrifugal liquid and are incorporated in supernatant；
S4, by supernatant with the flow velocity of 3-7BV/h by macroporous resin column, after dynamic adsorption saturation, deionized water with
The above-mentioned macroporous resin column of the flow velocity drip washing of 5-8BV/h is colourless to effluent, then with the organic solvent that volume fraction is 50%-70%
Eluting is carried out with the flow velocity of 8-12BV/h, eluent is collected, lyophilization obtains Herba Dendrobii lyophilized powder.
Preferably, the Milk Thistle extract prepares gained by following steps：
Dry Milk Thistle is placed in 90% methanol or ethanol solution that flash extracter adds 6 times of volumes, 1-3 point is processed
Clock, after solid-liquid separation, reclaims methanol or ethanol solution, concentration so that extract is in paste, then with water-saturated n-butanol to carrying
Take thing to extract 3 times, after recycling design, by drying concentrated in vacuo for extract, obtain Milk Thistle extract.
Preferably, the hemsley rockvine root extracting solution prepares gained by following steps：
S1, the hemsley rockvine root that cleans is placed in after flash extracter processes, is added for 3-5% by mass percentage compound
Enzymolysis solution, digests 1～2 hour by 20-30 DEG C, and per half an hour, once, control pH value is between 3.5～6.2 for stirring, oxygenation；
Enzymolysis solution is warming up to 85～100 DEG C after terminating by S2, enzymolysis, and enzyme denaturing 30～40 minutes is filtered, obtains hemsley rockvine root
Extracting solution.
Preferably, the Nostoc yeast powder prepares gained by following steps：
Take the Nostoc that cleans after draining to be placed in steam-explosion jar, it is 0.7- to be first passed through nitrogen to steam explosion pressure inside the tank
1.5MPa, explosion treatment 7-23min；Then it is 1.5-2.1MPa to be passed through rapidly steam to steam explosion pressure inside the tank, at steam explosion
After reason 0.8-2.8min, according to the ratio microbe inoculation leaven of inoculum concentration 1.5-1.7%, keeping temperature 25-35 DEG C, fermentation
After 48-54 hours, high temperature sterilize obtains Nostoc yeast powder.
Preferably, the microbe leaven is by lactobacilluss, Bacillus licheniformis, Corynebacterium glutamicum in mass ratio 3:
2:1 mixing gained.
Preferably, component of the complex enzyme hydrolysis liquid comprising following weight portion：
3～5 parts of neutral protease, 2～5 parts of flavor protease, 15 parts of paraplasm.
Preferably, the paraplasm includes 10% Sucus Granati, the Semen Maydis pulp of 2.5 parts of Fructus Lycopersici esculenti juice and 2.5 parts.
A kind of Herba Dendrobii compound injection, including above-mentioned formula.
A kind of Herba Dendrobii compound tablet, including above-mentioned formula.
The invention has the advantages that：
With homemade Herba Dendrobii lyophilized powder as main component, collaboration Olive leaf P.E, hemsley rockvine root extracting solution, Pueraria lobota
The interpolation of celestial rice yeast powder etc., can significantly improve the immunity of human body；By Milk Thistle extract, Lycium ruthenicum Murr. extract,
The synergism of Fructus Crataegi powder, fennel powder, Flos Chrysanthemi powder, Radix Panacis Quinquefolii powder etc., concrete preferably blood circulation promoting and blood stasis dispelling, the work(of supplementing QI and nourishing YIN
Effect, and cause eater to be difficult to get angry.
Specific embodiment
In order that objects and advantages of the present invention become more apparent, with reference to embodiments the present invention is carried out further
Describe in detail.It should be appreciated that specific embodiment described herein is not used to limit this only in order to explain the present invention
Bright.
Following examples, the Herba Dendrobii lyophilized powder for being used prepare gained by following steps：
S1, the Herba Dendrobii that drains will be cleaned it is placed in steam-explosion jar, it is 0.6- to be first passed through nitrogen to steam explosion pressure inside the tank
1.4MPa, explosion treatment 8-25min；Then it is 1.4-1.8MPa to be passed through rapidly steam to steam explosion pressure inside the tank, at steam explosion
After reason 0.5-2.5min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrated solution, obtains powder body；
S2, in powder body add 3-8 times of water, by mass percentage be 2-3% ratio add neutral protease, by quality
Percentage ratio is that 1-2% adds flavor protease, digests 1-2h, filter, obtain enzymolysis solution at 30-50 DEG C；
S3, by naturally to thaw again after the fermentation liquid quick freeze of gained, make age of starch precipitation in extract；Collect supernatant
Liquid, remainder are centrifuged, and collect centrifugal liquid and are incorporated in supernatant；
S4, by supernatant with the flow velocity of 3-7BV/h by macroporous resin column, after dynamic adsorption saturation, deionized water with
The above-mentioned macroporous resin column of the flow velocity drip washing of 5-8BV/h is colourless to effluent, then with the organic solvent that volume fraction is 50%-70%
Eluting is carried out with the flow velocity of 8-12BV/h, eluent is collected, lyophilization obtains Herba Dendrobii lyophilized powder.
The Milk Thistle extract for being used prepares gained by following steps：
Dry Milk Thistle is placed in 90% methanol or ethanol solution that flash extracter adds 6 times of volumes, 1-3 point is processed
Clock, after solid-liquid separation, reclaims methanol or ethanol solution, concentration so that extract is in paste, then with water-saturated n-butanol to carrying
Take thing to extract 3 times, after recycling design, by drying concentrated in vacuo for extract, obtain Milk Thistle extract.
The hemsley rockvine root extracting solution for being used prepares gained by following steps：
S1, the hemsley rockvine root that cleans is placed in after flash extracter processes, is added for 3-5% by mass percentage compound
Enzymolysis solution, digests 1～2 hour by 20-30 DEG C, and per half an hour, once, control pH value is between 3.5～6.2 for stirring, oxygenation；
Enzymolysis solution is warming up to 85～100 DEG C after terminating by S2, enzymolysis, and enzyme denaturing 30～40 minutes is filtered, obtains hemsley rockvine root
Extracting solution.
The Nostoc yeast powder for being used prepares gained by following steps：
Take the Nostoc that cleans after draining to be placed in steam-explosion jar, it is 0.7- to be first passed through nitrogen to steam explosion pressure inside the tank
1.5MPa, explosion treatment 7-23min；Then it is 1.5-2.1MPa to be passed through rapidly steam to steam explosion pressure inside the tank, at steam explosion
After reason 0.8-2.8min, according to the ratio microbe inoculation leaven of inoculum concentration 1.5-1.7%, keeping temperature 25-35 DEG C, fermentation
After 48-54 hours, high temperature sterilize obtains Nostoc yeast powder, and wherein, the microbe leaven is by lactobacilluss, lichens spore
Bacillus, Corynebacterium glutamicum in mass ratio 3:2:1 mixing gained, component of the complex enzyme hydrolysis liquid comprising following weight portion：In
Property protease 3～5 part, 2～5 parts of flavor protease, 15 parts of paraplasm.The paraplasm include 10% Sucus Granati, 2.5
Part Fructus Lycopersici esculenti juice and 2.5 parts of Semen Maydis pulp.
Turpentine derivatives of the organic solvent for natural origin.Isomery, discrimination of the turpentine derivatives for pinene
Change product；The Radix Panacis Quinquefolii powder is Radix Panacis Quinquefolii gained after micronizing；The Arillus Longan powder is dry Arillus Longan through superfine powder
Broken rear gained, other raw materials are commercially available.
Embodiment 1
A kind of Herba Dendrobii compound granules, are prepared from by the raw material of following weight portion：
30 parts of Herba Dendrobii lyophilized powder, 10 parts of Olive leaf P.E, 10 parts of Milk Thistle extract, 10 parts of vitamin C, west
10 parts of Radix Panacis Quinquefolii powder, 5 parts of Arillus Longan powder, 10 parts of hemsley rockvine root extracting solution, 5 parts of Sucus Zingberis, 5 parts of Fructus Crataegi powder, 3 parts of fennel powder, Flos Chrysanthemi
3 parts of powder, 5 parts of Lycium ruthenicum Murr. extract, 10 parts of Nostoc yeast powder, 5 parts of Radix Ginseng, 5 parts of the Radix Astragali.
Embodiment 2
A kind of Herba Dendrobii compound granules, are prepared from by the raw material of following weight portion：
40 parts of Herba Dendrobii lyophilized powder, 20 parts of Olive leaf P.E, 15 parts of Milk Thistle extract, 15 parts of vitamin C, west
20 parts of Radix Panacis Quinquefolii powder, 8 parts of Arillus Longan powder, 20 parts of hemsley rockvine root extracting solution, 10 parts of Sucus Zingberis, 10 parts of Fructus Crataegi powder, 5 parts of fennel powder, chrysanthemum
6 parts of pollen, 9 parts of Lycium ruthenicum Murr. extract, 15 parts of Nostoc yeast powder, 10 parts of Radix Ginseng, 10 parts of the Radix Astragali.
Embodiment 3
A kind of Herba Dendrobii compound granules, are prepared from by the raw material of following weight portion：
35 parts of Herba Dendrobii lyophilized powder, 15 parts of Olive leaf P.E, 12.5 parts of Milk Thistle extract, vitamin C 12.5
Part, 15 parts of Radix Panacis Quinquefolii powder, 6.5 parts of Arillus Longan powder, 15 parts of hemsley rockvine root extracting solution, 7.5 parts of Sucus Zingberis, 7.5 parts of Fructus Crataegi powder, Fructus Foeniculi
4 parts of powder, 4.5 parts of Flos Chrysanthemi powder, 7 parts of Lycium ruthenicum Murr. extract, 12.5 parts of Nostoc yeast powder, 7.5 parts of Radix Ginseng, 7.5 parts of the Radix Astragali.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Herba Dendrobii compound granules, it is characterised in that be prepared from by the raw material of following weight portion：
Herba Dendrobii lyophilized powder 30-40 parts, Olive leaf P.E 10-20 parts, Milk Thistle extract 10-15 parts, vitamin C 10-
15 parts, Radix Panacis Quinquefolii powder 10-20 parts, Arillus Longan powder 5-8 parts, hemsley rockvine root extracting solution 10-20 parts, Sucus Zingberis 5-10 parts, Fructus Crataegi powder 5-
10 parts, fennel powder 3-5 part, Flos Chrysanthemi powder 3-6 parts, Lycium ruthenicum Murr. extract 5-9 parts, Nostoc yeast powder 10-15 parts, Radix Ginseng 5-10
Part, Radix Astragali 5-10 parts.
2. a kind of Herba Dendrobii compound granules as claimed in claim 1, it is characterised in that the Herba Dendrobii lyophilized powder is by following
Step prepares gained：
S1, the Herba Dendrobii that drains will be cleaned it is placed in steam-explosion jar, it is 0.6-1.4MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 8-25min；Then it is 1.4-1.8MPa, Steam explosion treatment 0.5- to be passed through rapidly steam to steam explosion pressure inside the tank
After 2.5min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrated solution, obtains powder body；
S2, in powder body add 3-8 times of water, by mass percentage be 2-3% ratio add neutral protease, by quality percentage
Than flavor protease being added for 1-2%, digest 1-2h at 30-50 DEG C, filter, obtain enzymolysis solution；
S3, by naturally to thaw again after the fermentation liquid quick freeze of gained, make age of starch precipitation in extract；Collect supernatant,
Remainder is centrifuged, and collects centrifugal liquid and is incorporated in supernatant；
S4, by supernatant with the flow velocity of 3-7BV/h by macroporous resin column, after dynamic adsorption saturation, deionized water is with 5-
The above-mentioned macroporous resin column of the flow velocity drip washing of 8BV/h is colourless to effluent, then with the organic solvent that volume fraction is 50%-70% with
The flow velocity of 8-12BV/h carries out eluting, collects eluent, and lyophilization obtains Herba Dendrobii lyophilized powder.
3. a kind of Herba Dendrobii compound granules as claimed in claim 1, it is characterised in that the Milk Thistle extract is by following step
Gained is prepared suddenly：
Dry Milk Thistle is placed in 90% methanol or ethanol solution that flash extracter adds 6 times of volumes, 1-3 minutes are processed,
After solid-liquid separation, methanol or ethanol solution, concentration is reclaimed so that extract is in paste, then with water-saturated n-butanol to extracting
Thing is extracted 3 times, after recycling design, by drying concentrated in vacuo for extract, obtains Milk Thistle extract.
4. a kind of Herba Dendrobii compound granules as claimed in claim 1, it is characterised in that the hemsley rockvine root extracting solution pass through with
Lower step prepares gained：
S1, by clean hemsley rockvine root be placed in flash extracter process after, by mass percentage be 3-5% add complex enzyme hydrolysis
Liquid, digests 1～2 hour by 20-30 DEG C, and per half an hour, once, control pH value is between 3.5～6.2 for stirring, oxygenation；
Enzymolysis solution is warming up to 85～100 DEG C after terminating by S2, enzymolysis, and enzyme denaturing 30～40 minutes is filtered, and obtains hemsley rockvine root extraction
Liquid.
5. a kind of Herba Dendrobii compound granules as claimed in claim 1, it is characterised in that the Nostoc yeast powder is by following step
Gained is prepared suddenly：
Take the Nostoc that cleans after draining to be placed in steam-explosion jar, it is 0.7-1.5MPa to be first passed through nitrogen to steam explosion pressure inside the tank, quick-fried
Tear manages 7-23min；Then it is 1.5-2.1MPa, Steam explosion treatment 0.8- to be passed through rapidly steam to steam explosion pressure inside the tank
After 2.8min, according to the ratio microbe inoculation leaven of inoculum concentration 1.5-1.7%, keeping temperature 25-35 DEG C, ferment 48-54
After hour, high temperature sterilize obtains Nostoc yeast powder.
6. a kind of Herba Dendrobii compound granules as claimed in claim 5, it is characterised in that the microbe leaven is by lactic acid bar
Bacterium, Bacillus licheniformis, Corynebacterium glutamicum in mass ratio 3:2:1 mixing gained.
7. a kind of Herba Dendrobii compound granules as claimed in claim 4, it is characterised in that the complex enzyme hydrolysis liquid includes following weight
The component of part：
3～5 parts of neutral protease, 2～5 parts of flavor protease, 15 parts of paraplasm.
8. a kind of Herba Dendrobii compound granules as claimed in claim 7, it is characterised in that the paraplasm includes 10% Punica granatum L.
Juice, the Semen Maydis pulp of 2.5 parts of Fructus Lycopersici esculenti juice and 2.5 parts.
9. a kind of Herba Dendrobii compound injection, it is characterised in that including formula as claimed in claim 1.
10. a kind of Herba Dendrobii compound tablet, it is characterised in that including formula as claimed in claim 1.
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Application publication date: 20170315 |