CN106474179A - A kind of preparation method of beautiful millettia root microcapsule granule - Google Patents
A kind of preparation method of beautiful millettia root microcapsule granule Download PDFInfo
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- CN106474179A CN106474179A CN201610894904.2A CN201610894904A CN106474179A CN 106474179 A CN106474179 A CN 106474179A CN 201610894904 A CN201610894904 A CN 201610894904A CN 106474179 A CN106474179 A CN 106474179A
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- Prior art keywords
- beautiful millettia
- millettia root
- material solution
- preparation
- microcapsule granule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Abstract
The invention discloses a kind of preparation method of beautiful millettia root microcapsule granule, dry beautiful millettia root root tuber is crushed, add the ethanol that its quality is 46 times to dissolve, the tween emulsifier for beautiful millettia root quality 10 15% is added, is stirred, obtains core material solution；Will be soluble in water to beta cyclodextrin and xanthans, wall material solution is obtained, the wherein mass ratio of beta cyclodextrin, xanthans fat and water is 5 10:10‑15:100；Above-mentioned core material solution and wall material solution are 1 according to mass ratio:12 addition ultrasonic homogenizers carry out 20 30min of sterilization treatment；The slurry of gained is carried out microwave drying, the dried powder that water content is 6 8% is obtained, room temperature is cooled to, packaging, obtain final product beautiful millettia root microcapsule granule.This method can significantly improve the stability of beautiful millettia root, hence it is evident that extend storage period, also have preparation process is simple, simple to operate, the low, low cost and other advantages of power consumption, easily realize industrialized production.
Description
Technical field
The present invention relates to Technology of Processing Chinese Herbal Medicines field, specifically a kind of preparation method of beautiful millettia root microcapsule granule.
Background technology
Beautiful millettia root（Millettia specisoa Champ）,Another name pig's feet large bamboo hat with a conical crown and broad brim, Jin Zhonggen, beautiful millettia root, hang upside down Jin Zhong, big
Power potato, is pulse family pulse family Millettia plant.Beautiful millettia root is used as medicine with root, and Main Ingredients and Appearance is protein, starchiness and alkaloid etc..
Beautiful millettia root has flat liver, moistening lung, supports kidney qi-restoratives, the effect of strong muscle is active, cures mainly kidney deficiency, the deficiency of vital energy, pain in low back and legs, rheumatism, chronic
Hepatitis, bronchitis, cough, pulmonary tuberculosis etc. have good curative effect.Additionally, beautiful millettia root helps clearing heat and detoxicating effect eats frying food
Thing is excessive, understands thoroughly and stays up late, use beautiful millettia root Baoshang, has functions that subdhing swelling and detoxicating, improves constipation.Beautiful millettia root is collection medical value and food
The plant integrated with value, using value are quite varied.
Beautiful millettia root is simply simply dried by prior art to the deep processing of beautiful millettia root, and disintegrating process is obtained beautiful millettia root and does
Powder.But beautiful millettia root dry powder does not have the protection of other media, it is easy to oxidation drop in the presence of illumination, high temperature and oxygen
Solution, causes loss and the quality decline of nutrition.Microcapsule technology be with the macromolecular material of natural or synthesis as wall material, by liquid
The core substances such as body, solid or gas carry out packing, form a kind of technology of the microencapsulation with semi permeability or sealing cyst membrane.
Because microencapsulation can improve is wrapped the physical propertys such as the color of material, outward appearance, apparent density, dissolubility；Improve core material
The stability of matter, improves reactivity, durability, thermal sensitivity and the light sensitivity for being wrapped material, has been widely used medicine, agriculture
In the industry such as industry, chemicals, food processing, cosmetics, cause the extensive concern in the world.Therefore, microencapsulation is to improve beautiful millettia root
Dry powder stability, the effective way of prolongation storage period.
Content of the invention
The present invention is easy to occur oxidative degradation to exist for beautiful millettia root dry powder in the presence of illumination, high temperature and oxygen
Problem, provides a kind of preparation method of beautiful millettia root microcapsule granule.Beautiful millettia root microcapsule granule prepared by this method can increase its dispersion
Property and the tolerance to heat, light etc., significantly improve stability, be difficult mouldy, hence it is evident that extend storage period.
In order to realize object above, the technical solution used in the present invention is as follows:
A kind of preparation method of beautiful millettia root microcapsule granule, comprises the following steps：
（1）Prepare core：Dry beautiful millettia root root tuber is crushed, is added its quality for 4-6 times of ethanol dissolving, adds as ox
The tween emulsifier of big mechanical mass 10-15%, stirs, obtains core material solution；
（2）Prepare wall material：Will be soluble in water to beta-schardinger dextrin and xanthans, obtain wall material solution, wherein beta-schardinger dextrin, xanthans fat and
The mass ratio of water is 5-10:10-15:100；
（3）Ultrasonic wave homogeneous：Above-mentioned core material solution and wall material solution are 1 according to mass ratio:1-2 adds ultrasonic homogenizer to enter
Row sterilization treatment 20-30min；
（4）Microwave drying：By step（3）The slurry of gained carries out microwave drying, obtains dried powder of the water content for 6-8%, cooling
To room temperature, pack, obtain final product beautiful millettia root microcapsule granule.
Preferably, above step（1）Described crushing is that beautiful millettia root is crushed to 150-200 mesh.
Preferably, the mass concentration of the above ethanol is 90-95%.
Preferably, the above tween emulsifier is Tween 80 or the one kind in polysorbate60.
Preferably, during the above ultrasonic wave sterilization treatment, the power of ultrasonic wave is 200-250W, and temperature is 50-60 DEG C.
Preferably, the above microwave drying is dry at temperature is for 70-80 DEG C.
Compared with prior art, advantages of the present invention and have the beneficial effect that:
1st, beautiful millettia root microcapsule granule prepared by the inventive method not only can avoid its active ingredient and external environment, not be heated
Source, light source, air etc. affect, and significantly improve the stability of beautiful millettia root, hence it is evident that extend storage period, moreover it is possible to save beautiful millettia root very well
The full nutrition of former powder and active component, are easy to the technique of beautiful millettia root to process, preserve and transport.
2nd, this method selects beta-schardinger dextrin and soybean lecithin as wall material, improves the compactness of micro-capsule, and which is to beautiful millettia root
Full rate high, micro-capsule product property is stable.
3rd, compared with beautiful millettia root original powder, its water solubility is significantly improved beautiful millettia root micro-capsule prepared by this method, and is had in water
There is good dispersiveness, can be digested and assimilated by human body completely, at utmost play the drug effect of beautiful millettia root.
4th, the present invention is by carrying out sterilization treatment using ultrasonic technology, as the cavitation of ultrasonic wave causes homogeneous to imitate
Fruit is more preferable than high-pressure homogeneous, and when the beautiful millettia root micro-capsule that ultrasonic wave homogeneous is obtained is dissolved in water, nothing precipitation is produced.
5th, the inventive method adopts microwave K cryogenic treatment, and compared with conventional spray drying, temperature is lower, can be to greatest extent
Minimizing heat-sensitive substance loss.
6th, this method preparation process is simple, simple to operate, the low, low cost of power consumption, easily realize industrialized production.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, but is not limited to protection scope of the present invention.
Embodiment 1
A kind of preparation method of beautiful millettia root microcapsule granule, comprises the following steps：
（1）Prepare core：The beautiful millettia root root tuber that 100kg is dry is crushed to 150 mesh, adds the second that 500kg mass concentration is 95%
Alcohol dissolves, and adds 10kg Tween 80 emulsifying agent, stirs, obtain core material solution；
（2）Prepare wall material：Will be soluble in water to beta-schardinger dextrin and xanthans, obtain wall material solution, wherein beta-schardinger dextrin, xanthans fat and
The mass ratio of water is 8:12:100；
（3）Ultrasonic wave homogeneous：Above-mentioned core material solution and wall material solution are 1 according to mass ratio:1 adds ultrasonic homogenizer,
Power is 200W, temperature is sterilization treatment 30min at 60 DEG C；
（4）Microwave drying：By step（3）The slurry of gained is microwave drying at 70 DEG C in temperature, obtains the drying that water content is 8%
Powder, is cooled to room temperature, packaging, obtains final product beautiful millettia root microcapsule granule.
Embodiment 2
A kind of preparation method of beautiful millettia root microcapsule granule, comprises the following steps：
（1）Prepare core：The beautiful millettia root root tuber that 100kg is dry is crushed to 150 mesh, adds the second that 600kg mass concentration is 90%
Alcohol dissolves, and adds 12kg Tween 80 emulsifying agent, stirs, obtain core material solution；
（2）Prepare wall material：Will be soluble in water to beta-schardinger dextrin and xanthans, obtain wall material solution, wherein beta-schardinger dextrin, xanthans fat and
The mass ratio of water is 5:15:100；
（3）Ultrasonic wave homogeneous：Above-mentioned core material solution and wall material solution are 1 according to mass ratio:2 add ultrasonic homogenizer,
Power is 250W, temperature is sterilization treatment 20min at 60 DEG C；
（4）Microwave drying：By step（3）The slurry of gained is microwave drying at 80 DEG C in temperature, obtains the drying that water content is 6%
Powder, is cooled to room temperature, packaging, obtains final product beautiful millettia root microcapsule granule.
Embodiment 3
A kind of preparation method of beautiful millettia root microcapsule granule, comprises the following steps：
（1）Prepare core：The beautiful millettia root root tuber that 100kg is dry is crushed to 200 mesh, adds the second that 400kg mass concentration is 95%
Alcohol dissolves, and adds 15kg polysorbate60 emulsifying agent, stirs, obtain core material solution；
（2）Prepare wall material：Will be soluble in water to beta-schardinger dextrin and xanthans, obtain wall material solution, wherein beta-schardinger dextrin, xanthans fat and
The mass ratio of water is 10:10:100；
（3）Ultrasonic wave homogeneous：Above-mentioned core material solution and wall material solution are 1 according to mass ratio:1.5 add ultrasonic homogenizer,
Power be 250W, temperature be 50 DEG C at sterilization treatment 25min；
（4）Microwave drying：By step（3）The slurry of gained is microwave drying at 75 DEG C in temperature, obtains the drying that water content is 7%
Powder, is cooled to room temperature, packaging, obtains final product beautiful millettia root microcapsule granule.
Embodiment 4
A kind of preparation method of beautiful millettia root microcapsule granule, comprises the following steps：
（1）Prepare core：The beautiful millettia root root tuber that 100kg is dry is crushed to 200 mesh, adds the second that 500kg mass concentration is 90%
Alcohol dissolves, and adds 12kg polysorbate60 emulsifying agent, stirs, obtain core material solution；
（2）Prepare wall material：Will be soluble in water to beta-schardinger dextrin and xanthans, obtain wall material solution, wherein beta-schardinger dextrin, xanthans fat and
The mass ratio of water is 8:15:100；
（3）Ultrasonic wave homogeneous：Above-mentioned core material solution and wall material solution are 1 according to mass ratio:1.5 add ultrasonic homogenizer,
Power be 200W, temperature be 60 DEG C at sterilization treatment 30min；
（4）Microwave drying：By step（3）The slurry of gained is microwave drying at 80 DEG C in temperature, obtains the drying that water content is 6%
Powder, is cooled to room temperature, packaging, obtains final product beautiful millettia root microcapsule granule.
The preferred embodiments of the present invention are the foregoing is only, the present invention is not limited to, for those skilled in the art
For member, the present invention can have various modifications and variations.All any modifications that within the spirit and principles in the present invention, is made,
Equivalent, improvement etc., should be included within the scope of the present invention.
Claims (6)
1. a kind of preparation method of beautiful millettia root microcapsule granule, it is characterised in that:Comprise the following steps：
（1）Prepare core：Dry beautiful millettia root root tuber is crushed, is added its quality for 4-6 times of ethanol dissolving, adds as ox
The tween emulsifier of big mechanical mass 10-15%, stirs, obtains core material solution；
（2）Prepare wall material：Will be soluble in water to beta-schardinger dextrin and xanthans, obtain wall material solution, wherein beta-schardinger dextrin, xanthans fat and
The mass ratio of water is 5-10:10-15:100；
（3）Ultrasonic wave homogeneous：Above-mentioned core material solution and wall material solution are 1 according to mass ratio:1-2 adds ultrasonic homogenizer to enter
Row sterilization treatment 20-30min；
（4）Microwave drying：By step（3）The slurry of gained carries out microwave drying, obtains dried powder of the water content for 6-8%, cooling
To room temperature, pack, obtain final product beautiful millettia root microcapsule granule.
2. the preparation method of beautiful millettia root microcapsule granule according to claim 1, it is characterised in that:Step（1）Described crushing
It is that beautiful millettia root is crushed to 150-200 mesh.
3. the preparation method of beautiful millettia root microcapsule granule according to claim 1, it is characterised in that:The mass concentration of the ethanol
For 90-95%.
4. the preparation method of beautiful millettia root microcapsule granule according to claim 1, it is characterised in that:The tween emulsifier is for telling
One kind in temperature 80 or polysorbate60.
5. the preparation method of beautiful millettia root microcapsule granule according to claim 1, it is characterised in that:The ultrasonic wave sterilization treatment
When ultrasonic wave power be 200-250W, temperature be 50-60 DEG C.
6. the preparation method of beautiful millettia root microcapsule granule according to claim 1, it is characterised in that:The microwave drying be in temperature
Spend for drying at 70-80 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610894904.2A CN106474179A (en) | 2016-10-14 | 2016-10-14 | A kind of preparation method of beautiful millettia root microcapsule granule |
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| CN201610894904.2A CN106474179A (en) | 2016-10-14 | 2016-10-14 | A kind of preparation method of beautiful millettia root microcapsule granule |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468669A (en) * | 2017-09-27 | 2017-12-15 | 右江民族医学院 | A kind of preparation method of Gastrodin microcapsule granule |
| CN107648197A (en) * | 2017-09-27 | 2018-02-02 | 右江民族医学院 | The microencapsulation method of flax lignan |
| CN107789335A (en) * | 2017-09-27 | 2018-03-13 | 右江民族医学院 | The preparation method of qinghaosu microcapsules |
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| CN103040924A (en) * | 2013-01-14 | 2013-04-17 | 海南师范大学 | Radix millettiae speciosae extract and application thereof in preparing drugs for treating osteoporosis |
| CN103735532A (en) * | 2014-01-15 | 2014-04-23 | 山东星光生物科技有限公司 | Lutein ester microcapsule and preparation method thereof |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040924A (en) * | 2013-01-14 | 2013-04-17 | 海南师范大学 | Radix millettiae speciosae extract and application thereof in preparing drugs for treating osteoporosis |
| CN103735532A (en) * | 2014-01-15 | 2014-04-23 | 山东星光生物科技有限公司 | Lutein ester microcapsule and preparation method thereof |
Non-Patent Citations (1)
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468669A (en) * | 2017-09-27 | 2017-12-15 | 右江民族医学院 | A kind of preparation method of Gastrodin microcapsule granule |
| CN107648197A (en) * | 2017-09-27 | 2018-02-02 | 右江民族医学院 | The microencapsulation method of flax lignan |
| CN107789335A (en) * | 2017-09-27 | 2018-03-13 | 右江民族医学院 | The preparation method of qinghaosu microcapsules |
| CN107648197B (en) * | 2017-09-27 | 2020-04-03 | 右江民族医学院 | Microencapsulation method of secoisolariciresinol diglucoside |
| CN107468669B (en) * | 2017-09-27 | 2020-04-03 | 右江民族医学院 | Preparation method of gastrodin micro-capsule granules |
| CN107789335B (en) * | 2017-09-27 | 2020-04-03 | 右江民族医学院 | Preparation method of artemisinin microcapsules |
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Application publication date: 20170308 |
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