CN106309527A - Method for preparing panax notoginseng microcapsules - Google Patents
Method for preparing panax notoginseng microcapsules Download PDFInfo
- Publication number
- CN106309527A CN106309527A CN201610894870.7A CN201610894870A CN106309527A CN 106309527 A CN106309527 A CN 106309527A CN 201610894870 A CN201610894870 A CN 201610894870A CN 106309527 A CN106309527 A CN 106309527A
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- CN
- China
- Prior art keywords
- radix notoginseng
- microcapsule
- material solution
- panax notoginseng
- method preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
Abstract
The invention discloses a method for preparing panax notoginseng microcapsules. The method comprises the following steps: grinding dried panax notoginseng, adding ethanol for dissolving, adding a Tween emulsifier, and uniformly stirring, thereby obtaining a core material solution; dissolving Arabic gum and glycerin monostearate in water, thereby obtaining a wall material solution, wherein the mass ratio of the Arabic gum to glycerin monostearate to water is (10-15):(5-10):100; adding the core material solution and the wall material solution into an ultrasonic homogenizer for homogenizing 10-20 minutes according to a mass ratio of 1:(1-3); and performing microwave drying on the slurry obtained in the previous step, so as to obtain dried powder with the moisture content of 6-8%, cooling to room temperature, and packaging, thereby obtaining the panax notoginseng microcapsules. According to the panax notoginseng microcapsules prepared by the method, the active ingredients can be prevented from being isolated from the outside, the stability of the panax notoginseng is obviously improved, the storage period is obviously prolonged, the complete nutrition and active ingredients of the panax notoginseng raw powder can be well preserved, and technical processing, storage and transportation of the panax notoginseng can be facilitated.
Description
Technical field
The present invention relates to Technology of Processing Chinese Herbal Medicines field, a kind of method preparing Radix Notoginseng microcapsule.
Background technology
Dry root that Radix Notoginseng is panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen and root
Stem, another name Radix Notoginseng, Panax pseudoginseng, Radix Notoginseng, literary composition state Radix Notoginseng, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) etc..Radix Notoginseng is rich in arasaponin, Radix Notoginseng polysaccharide, Radix Notoginseng
Element, flavone effective ingredient, can be used for treating the various inside and outside hemorrhages such as traumatic hemorrhage, blood stasis, gastrorrhagia, hematuria；Expansion blood
Pipe, thrombus, improves microcirculation, prevents and treat hyperlipidemia, cholesterol increases, coronary heart diseases and angina pectoris, apoplexy sequela
Deng cardiovascular and cerebrovascular disease；The hepatopathy such as fatty liver, hepatic fibrosis and lose blood, body deficient syndrome that puerperal, the reason such as prolonged illness cause.
Radix Notoginseng is simply simply dried by prior art by the deep processing of pseudo-ginseng, and disintegrating process prepares Radix Notoginseng powder, and three
Seven powder " it is the main component of YUNNAN BAIYAO.But Radix Notoginseng powder does not has the protection of other medium, in the effect of illumination, high temperature and oxygen
Under be easy to oxidative degradation, cause the loss of nutrition and quality to decline.Microcapsule technology is with the natural or height of synthesis
Molecular material is wall material, and the core substances such as liquid, solid or gas carry out encapsulation, is formed and has semi permeability or seal cyst membrane
A kind of technology of microencapsulation.Because micro encapsulation can improve is wrapped the color of material, outward appearance, apparent density, dissolubility
Etc. physical property；Improve the stability of core substance, improve and be wrapped the reactivity of material, durability, thermal sensitivity and photosensitive
Property, have been widely used in the industry such as medicine, agricultural, chemicals, food processing, cosmetics, cause the extensive concern in the world.Cause
This, micro encapsulation is to improve Radix Notoginseng powder stability, the effective way extending storage period.
Summary of the invention
The present invention is directed to Radix Notoginseng powder be easy to asking of oxidative degradation existence under the effect of illumination, high temperature and oxygen
Topic, it is provided that a kind of method preparing Radix Notoginseng microcapsule.Radix Notoginseng microcapsule prepared by this method can increase its dispersibility and to heat, light
Deng toleration, significantly improve stability, be difficult to mouldy, hence it is evident that extend storage period.
In order to realize object above, the technical solution used in the present invention is as follows:
A kind of method preparing Radix Notoginseng microcapsule, comprises the following steps:
(1) prepare core: pulverized by dry Radix Notoginseng, add the ethanol that its quality is 4-6 times and dissolve, add as Radix Notoginseng quality
The tween emulsifier of 5-10%, stirs, and obtains core material solution；
(2) wall material is prepared: by soluble in water to arabic gum and glyceryl monostearate, obtain wall material solution, wherein arabic gum, list
The mass ratio of tristerin and water is 10-15:5-10:100；
(3) ultrasound wave homogenizing: be that 1:1-3 adds ultrasonic homogenizer and enters according to mass ratio by above-mentioned core material solution and wall material solution
Row homogenizing processes 10-20min；
(4) microwave drying: the slurry of step (3) gained is carried out microwave drying, obtains the dried powder that water content is 6-8%, cooling
To room temperature, packaging, obtain Radix Notoginseng microcapsule.
Preferably, the pulverizing described in above step (1) is that Radix Notoginseng powder is broken to 200-250 mesh.
Preferably, the mass concentration of the above ethanol is 90-95%.
Preferably, the one during the above tween emulsifier is Tween 80 or polysorbate60.
Preferably, when the above ultrasound wave homogenizing processes, the power of ultrasound wave is 250-300W, and temperature is 50-60 DEG C.
Preferably, the above microwave drying is to be dried at temperature is 70-80 DEG C.
Compared with prior art, advantages of the present invention and having the beneficial effect that
1, the Radix Notoginseng microcapsule that prepared by the inventive method is possible not only to avoid its effective ingredient and external environment, not by thermal source,
Light source, air etc. affect, and significantly improve the stability of Radix Notoginseng, hence it is evident that extend storage period, moreover it is possible to save the former powder of Radix Notoginseng very well
Full nutrition and active component, it is simple to the processes of Radix Notoginseng, preserve and transport.
2, this method selects beta-schardinger dextrin-and soybean lecithin as wall material, improves the compactness of microcapsule, and it is to Radix Notoginseng
Full rate high, microcapsule product stable in properties.
3, compared with the Radix Notoginseng microcapsule powder former with Radix Notoginseng that prepared by this method, its water solublity significantly improves, and has in water
Good dispersibility, it is possible to absorbed by human body catapepsis, at utmost plays the drug effect of Radix Notoginseng.
4, the present invention is by using ultrasonic technology to carry out homogenizing process, owing to the cavitation of ultrasound wave makes homogenizing imitate
Fruit is more preferable than high pressure homogenize, and the Radix Notoginseng microcapsule obtained through ultrasound wave homogenizing is dissolved in water, produces without precipitation.
5, the inventive method uses microwave K cryogenic treatment, and compared with conventional spray drying, temperature is lower, can be to greatest extent
Reduce heat-sensitive substance loss.
6, this method preparation technology is simple, simple to operate, consume energy low, low cost, easily realizes industrialized production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, but is not limited to protection scope of the present invention.
Embodiment 1
A kind of method preparing Radix Notoginseng microcapsule, comprises the following steps:
(1) prepare core: the Radix Notoginseng powder being dried by 100kg is broken to 200 mesh, add the ethanol that 500kg mass concentration is 90% molten
Solve, add the Tween 80 emulsifying agent of 8kg, stir, obtain core material solution；
(2) wall material is prepared: by soluble in water to arabic gum and glyceryl monostearate, obtain wall material solution, wherein arabic gum, list
The mass ratio of tristerin and water is 10:8:100；
(3) ultrasound wave homogenizing: be that 1:2 adds ultrasonic homogenizer according to mass ratio by above-mentioned core material solution and wall material solution,
Power is 250W, temperature is that at 60 DEG C, homogenizing processes 20min；
(4) microwave drying: by slurry microwave drying at temperature is 70 DEG C of step (3) gained, obtaining water content is 8% be dried
Powder, is cooled to room temperature, packaging, obtains Radix Notoginseng microcapsule.
Embodiment 2
A kind of method preparing Radix Notoginseng microcapsule, comprises the following steps:
(1) prepare core: the Radix Notoginseng powder being dried by 100kg is broken to 200 mesh, add the ethanol that 400kg mass concentration is 95% molten
Solve, add the Tween 80 emulsifying agent of 5kg, stir, obtain core material solution；
(2) wall material is prepared: by soluble in water to arabic gum and glyceryl monostearate, obtain wall material solution, wherein arabic gum, list
The mass ratio of tristerin and water is 15:7:100；
(3) ultrasound wave homogenizing: be that 1:1 adds ultrasonic homogenizer according to mass ratio by above-mentioned core material solution and wall material solution,
Power is 300W, temperature is that at 55 DEG C, homogenizing processes 10min；
(4) microwave drying: by slurry microwave drying at temperature is 80 DEG C of step (3) gained, obtaining water content is 6% be dried
Powder, is cooled to room temperature, packaging, obtains Radix Notoginseng microcapsule.
Embodiment 3
A kind of method preparing Radix Notoginseng microcapsule, comprises the following steps:
(1) prepare core: the Radix Notoginseng powder being dried by 100kg is broken to 250 mesh, add the ethanol that 600kg mass concentration is 90% molten
Solve, add the polysorbate60 emulsifying agent of 10kg, stir, obtain core material solution；
(2) wall material is prepared: by soluble in water to arabic gum and glyceryl monostearate, obtain wall material solution, wherein arabic gum, list
The mass ratio of tristerin and water is 12:10:100；
(3) ultrasound wave homogenizing: be that 1:3 adds ultrasonic homogenizer according to mass ratio by above-mentioned core material solution and wall material solution,
Power is 250W, temperature is that at 60 DEG C, homogenizing processes 15min；
(4) microwave drying: by slurry microwave drying at temperature is 75 DEG C of step (3) gained, obtaining water content is 7% be dried
Powder, is cooled to room temperature, packaging, obtains Radix Notoginseng microcapsule.
Embodiment 4
A kind of method preparing Radix Notoginseng microcapsule, comprises the following steps:
(1) prepare core: the Radix Notoginseng powder being dried by 100kg is broken to 250 mesh, add the ethanol that 400kg mass concentration is 95% molten
Solve, add the polysorbate60 emulsifying agent of 10kg, stir, obtain core material solution；
(2) wall material is prepared: by soluble in water to arabic gum and glyceryl monostearate, obtain wall material solution, wherein arabic gum, list
The mass ratio of tristerin and water is 15:5:100；
(3) ultrasound wave homogenizing: be that 1:1.5 adds ultrasonic homogenizer according to mass ratio by above-mentioned core material solution and wall material solution,
Power be 250W, temperature be at 50 DEG C homogenizing process 20min；
(4) microwave drying: by slurry microwave drying at temperature is 80 DEG C of step (3) gained, obtaining water content is 6% be dried
Powder, is cooled to room temperature, packaging, obtains Radix Notoginseng microcapsule.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for those skilled in the art
For Yuan, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, any amendment of being made,
Equivalent, improvement etc., should be included within the scope of the present invention.
Claims (6)
1. the method preparing Radix Notoginseng microcapsule, it is characterised in that: comprise the following steps:
(1) prepare core: pulverized by dry Radix Notoginseng, add the ethanol that its quality is 4-6 times and dissolve, add as Radix Notoginseng quality
The tween emulsifier of 5-10%, stirs, and obtains core material solution；
(2) wall material is prepared: by soluble in water to arabic gum and glyceryl monostearate, obtain wall material solution, wherein arabic gum, list
The mass ratio of tristerin and water is 10-15:5-10:100；
(3) ultrasound wave homogenizing: be that 1:1-3 adds ultrasonic homogenizer and enters according to mass ratio by above-mentioned core material solution and wall material solution
Row homogenizing processes 10-20min；
(4) microwave drying: the slurry of step (3) gained is carried out microwave drying, obtains the dried powder that water content is 6-8%, cooling
To room temperature, packaging, obtain Radix Notoginseng microcapsule.
The method preparing Radix Notoginseng microcapsule the most according to claim 1, it is characterised in that: the pulverizing described in step (1) be by
Radix Notoginseng powder is broken to 200-250 mesh.
The method preparing Radix Notoginseng microcapsule the most according to claim 1, it is characterised in that: the mass concentration of described ethanol is
90-95%。
The method preparing Radix Notoginseng microcapsule the most according to claim 1, it is characterised in that: described tween emulsifier is Tween 80
Or the one in polysorbate60.
The method preparing Radix Notoginseng microcapsule the most according to claim 1, it is characterised in that: super when described ultrasound wave homogenizing processes
The power of sound wave is 250-300W, and temperature is 50-60 DEG C.
The method preparing Radix Notoginseng microcapsule the most according to claim 1, it is characterised in that: described microwave drying is to be in temperature
It is dried at 70-80 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610894870.7A CN106309527A (en) | 2016-10-14 | 2016-10-14 | Method for preparing panax notoginseng microcapsules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610894870.7A CN106309527A (en) | 2016-10-14 | 2016-10-14 | Method for preparing panax notoginseng microcapsules |
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| CN106309527A true CN106309527A (en) | 2017-01-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107789335A (en) * | 2017-09-27 | 2018-03-13 | 右江民族医学院 | The preparation method of qinghaosu microcapsules |
Citations (2)
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|---|---|---|---|---|
| CN1593504A (en) * | 2004-07-15 | 2005-03-16 | 天津大学 | Microencapsulation method of Chinese traditional medicine |
| CN104324675A (en) * | 2014-10-16 | 2015-02-04 | 浙江春宝胶囊有限公司 | Microcapsule production technology |
-
2016
- 2016-10-14 CN CN201610894870.7A patent/CN106309527A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593504A (en) * | 2004-07-15 | 2005-03-16 | 天津大学 | Microencapsulation method of Chinese traditional medicine |
| CN104324675A (en) * | 2014-10-16 | 2015-02-04 | 浙江春宝胶囊有限公司 | Microcapsule production technology |
Non-Patent Citations (2)
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| 王宝琴等: "微胶囊化粉末油脂制品的技术研究", 《粮油加工》 * |
| 王显伦: "凝聚法制备微胶囊技术研究", 《郑州粮食学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107789335A (en) * | 2017-09-27 | 2018-03-13 | 右江民族医学院 | The preparation method of qinghaosu microcapsules |
| CN107789335B (en) * | 2017-09-27 | 2020-04-03 | 右江民族医学院 | Preparation method of artemisinin microcapsules |
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Application publication date: 20170111 |