CN106474151B - A kind of animal core-shell structure zinc oxide clay antidiarrhoea formulation and preparation method thereof - Google Patents
A kind of animal core-shell structure zinc oxide clay antidiarrhoea formulation and preparation method thereof Download PDFInfo
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- CN106474151B CN106474151B CN201611008158.9A CN201611008158A CN106474151B CN 106474151 B CN106474151 B CN 106474151B CN 201611008158 A CN201611008158 A CN 201611008158A CN 106474151 B CN106474151 B CN 106474151B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
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Abstract
The invention belongs to animal health field more particularly to a kind of animal zinc oxide anti diar rhea products and preparation method thereof.A kind of animal core-shell structure zinc oxide clay antidiarrhoea formulation, said preparation are graininess, and the sandwich layer of particle is zinc oxide, and the outer layer covers of zinc oxide are provided with argillic horizon, the outer layer covers of particle are provided with enteric coating.The antidiarrhoea formulation is not corroded by gastric acid, and release is pinpointed in enteron aisle.Clay can restrain the epithelial cell being damaged in enteron aisle, protect enteron aisle, control diarrhea instead of antibiotic.Dosage is far smaller than zinc oxide, reduces aquaculture cost, reduces zinc discharge and Soil Environmental Pollution.
Description
Technical field
The invention belongs to animal health field more particularly to a kind of animal zinc oxide anti diar rhea product and its preparation sides
Method.
Background technique
Zinc is a kind of necessary microelement of animal body, is the constituent of a variety of enzymes, and participates in fat, carbohydrate
With the metabolism of the nutriments such as vitamin.It is found in the numerous studies in medicine and animal nutrition field, zinc and body are exempted from
Epidemic disease function has substantial connection, influences specificity, non-specific and mucosal immune function performance, and body is being maintained normally to exempt from
It epidemic disease function and prevents bacterium, there is in terms of parasitic infestation good result.Research shows that high dose zinc oxide is added in diet, it is right
Weanling pig has the function of reducing diarrhea, improves daily gain, and domestic and foreign scholars are to adding high high dose in weanling pig daily ration
The application effect of zinc has carried out extensive research.It can effectively anti-system a large number of studies show that adding appropriate high oxidation zinc in Piglet Diets
Early weaning piglet stress syndrome, reduce diarrhea of weaned piglets rate, improve efficiency of feed utilization, promote piglet growth, improve young
Pig growth performance enhances piglet immunological function.
But high dose zinc oxide use also bring series adverse effect, 1) pollution environment.Pig has automatic adjust
The ability for saving absorption and the excretion of zinc to maintain internal zinc stable.Intracorporal zinc is mainly drained by enteron aisle, the big portion of zinc in excrement
Divide from unabsorbed external source zinc in daily ration.In general remaining zinc is containing being half of additive amount or so in excrement, so
The zinc accumulation of high dose causes environmental pollution into soil.Long-term accumulation, which will cause soil, no longer has arability.And zinc
There is very big toxicity to fish and aquatile.For excessive zinc after carcass is drained, the serious polluted underground water of meeting interferes herding
The sustainable development of industry.2) the high zinc dependence for causing piglet, adversely affects the growth in later period.Prolonged high zinc
Phenomena such as nursing will cause pig growth inhibition, feed intake decline, ochrodermia, coat slightly disorderly crimp.It is primarily due to zinc pair
The inhibiting effect of bacterium all works to harmful bacteria and beneficial bacterium in enteron aisle, when being stopped using after Pharmacological Level of Zinc is used for a long time,
Pathogen is easier to be colonized and breed in enteron aisle than beneficial bacterium, and diarrhea is induced so as to cause enteric flora disturbance, thus right
The growth in later period generates adverse effect instead.
The zinc oxide substitute studied at present mainly has organic zinc, basic zinc chloride, nanometer porous zinc oxide and coating oxygen
Change zinc.Foreign countries have scholar studies have shown that the mechanism of action of zinc oxide and the bioavilability of zinc have no bearing on.The effect of zinc oxide
It is not rely on zinc ion, but zinc oxide itself, active position are enteron aisles.General zinc oxide can be neutralized by gastric acid zinc from
Son causes the zinc oxide quantity for reaching enteron aisle to reduce, and impact effect.Carrying out coating to zinc oxide can be avoided or reduce oxidation
Consumption of the zinc in gastric acid is discharged in enteron aisle and is played a role in the form of zinc oxide.
Many researchs confirm the effect of coated zinc oxide both at home and abroad.It is to reduce zinc oxide to the coated main purpose of zinc oxide
Consumption in gastric acid.Regular oxidation zinc capsulating material mostly uses oleic acid.But to play good coating effect, oil need to be increased
Sour dosage.But oleic acid dosage excessively will cause animal intestinal tract discomfort.
Summary of the invention
In order to solve the above technical problems, it is an object of the present invention to provide a kind of animals is aoxidized with core-shell structure
Zinc clay antidiarrhoea formulation, another object of the present invention are to provide the preparation method of above-mentioned preparation.The present invention prepares
Zinc oxide anti diar rhea product in addition to further decreasing the dosage of zinc oxide, while improving the anti diar rhea function of product.
In order to realize first above-mentioned purpose, present invention employs technical solutions below:
A kind of animal core-shell structure zinc oxide clay antidiarrhoea formulation, said preparation are graininess, and the sandwich layer of particle is oxygen
Change zinc, the outer layer covers of zinc oxide are provided with argillic horizon, the outer layer covers of particle are provided with enteric coating.
Preferably, said preparation includes: zinc oxide 25%-95%, clay 4%-65%, enteric coating by mass percentage
1%-10%。
As further preferably, said preparation includes: zinc oxide 25%-50%, clay 20%-40%, enteric packet by mass percentage
Clothing agent 1%-6%.
Preferably, the clay be selected from montmorillonite, zeolite, bentonite, concave convex rod, sepiolite, hectorite, vermiculite and
The mixing of one or more of kaolin.
As further preferably, the clay is selected from the mixing of montmorillonite, zeolite and bentonite one or more.
Preferably, the material of the enteric coating is selected from shellac, Cellulose Acetate Phthalate, seaweed glue, poly- second
One or more of enol acetate phthalate ester, fatty acid, acrylic resin, hydroxypropyl methyl cellulose phthalate mix
It closes.
In order to realize second above-mentioned purpose, present invention employs technical solutions below:
A method of preparation described in above-mentioned any one technical solution being prepared, this method includes the following steps:
1) suitable quantity of water is added in oxidisability powder, and the zinc oxide of required partial size and shape is caused in Granulation Equipments；
2) clay powder is added in zinc oxide core, and suitable quantity of water is added, clay powders are uniformly wrapped in zinc oxide
The outer surface of core forms one layer of clay shell；
3) by spray or leaching technology, one layer of enteric-coating material is coated in zinc oxide-clay particle surface；
4) sieving after particle drying is obtained into the formulation products.
Preferably, the step 1) is additionally added binder, binder and water are added to oxidation in a manner of aqueous solution
In property powder.As further preferably, the binder is one of starch, gelatin, cyclodextrin or a variety of.
Preferably, the particle of the step 4) formulation products is 10 ~ 80 mesh.
The present invention due to the adoption of the above technical solution, using viscosity and coating agent double-coating zinc oxide.The present invention
Have the characteristics that following:
1, the present invention is not corroded by gastric acid, and release is pinpointed in enteron aisle, further decreases consumption of the zinc oxide in gastric acid,
Inhibition of the more zinc oxide of effective guarantee to intestinal flora；Dosage of the invention is far smaller than zinc oxide, reduces aquaculture cost,
Reduce zinc discharge and Soil Environmental Pollution；
2, the addition of clay can play synergistic with zinc oxide in enteron aisle other than having the function of protection zinc oxide
Anti-CaM antibody；Montmorillonite, zeolite minerals especially in clay, the absorption to harmful bacteria in enteron aisle and the guarantor to intestinal mucosa
Shield has obvious effects on；
3, since clay is easier to form uniform inclusion enclave with Zinc oxide particles, it is possible to reduce the dosage of clay is realized
Clay dosage is controllable, provides space for the usage amount of different clays, and oleic acid is used to wrap up, and a large amount of oleic acid is needed, few
Amount oleic acid then cannot achieve package.
Specific implementation method
Below with reference to embodiment, specific implementation method of the invention is further described.Following embodiment is only used for more
The technical solution of invention is clearly demonstrated, and not intended to limit the protection scope of the present invention.
Embodiment 1
200g zinc oxide is weighed, in Granulation Equipments, a small amount of water is sprayed into, zinc oxide is bonded to little particle.Weigh 300g
Montmorillonite powder is added step-wise in the Granulation Equipments equipped with Zinc oxide particles, start equipment make montmorillonite powder uniformly adhere to
Zinc oxide particle surfaces, and suitable water is added, promote the adherency of montmorillonite powder.Then 6g seaweed glue alcohol water is dissolved in mix
In solution, it is sprayed to zinc oxide/montmorillonite particle surface, one layer is formed and crosses stomach protective film.Particle is dried, is sieved, is produced
Product.
Embodiment 2
300g zinc oxide is weighed, in Granulation Equipments, sprays into a small amount of amidin, degerming zinc oxide is bonded to small
Grain.600g montmorillonite powder is weighed, is added step-wise in the Granulation Equipments equipped with Zinc oxide particles, starting equipment keeps montmorillonite powder equal
Even adherency and zinc oxide particle surfaces, and suitable water is added, promote the adherency of montmorillonite powder.Then by 10g polyvinyl alcohol
Acetate phthalate ester is dissolved in alcohol water mixed solution, is sprayed to zinc oxide/montmorillonite particle surface, is formed one layer and is crossed stomach guarantor
Cuticula.Particle is dried, is sieved, obtains product.
Embodiment 3
200g zinc oxide is weighed, in Granulation Equipments, sprays into a small amount of amidin, degerming zinc oxide is bonded to small
Grain.200g zeolite powder is weighed, is added step-wise in the Granulation Equipments equipped with Zinc oxide particles, starting equipment keeps montmorillonite powder uniform
Adherency and zinc oxide particle surfaces, and suitable water is added, promotes the adherency of montmorillonite powder.Then 15 fatty acid are dissolved in
In alcohol water mixed solution, it is sprayed to zinc oxide/montmorillonite particle surface, one layer is formed and crosses stomach protective film.Particle is dried, mistake
Sieve, obtains product.
The coated zinc oxide sample of embodiment 1,2,3 is subjected to diarrhea frequency in common zinc oxide under identical feeding conditions
Comparative test.Eat the calculation method of diarrhea frequency are as follows:
Diarrhea frequency (%)=Σ (diarrhea piglet head number × grice diarrhoea number of days)/(test piglet head number × test number of days) ×
100。
During test, the additive amount in basal diet of common zinc oxide is 3000mg/kg, and coated zinc oxide adds
Dosage is 150mg/kg.The data of test are as shown in table 2.
Table 1, basal diet composition
The influence (%) of table 2, common zinc oxide and coated zinc oxide to diarrhea of weaned piglets frequency
。
Claims (9)
1. a kind of animal core-shell structure zinc oxide clay antidiarrhoea formulation, said preparation is graininess, and the sandwich layer of particle is oxidation
The outer layer covers of zinc, zinc oxide are provided with argillic horizon, the outer layer covers of particle are provided with enteric coating, it is characterised in that the system
Agent includes: zinc oxide 25%-50%, clay 20%-65%, enteric coating 1%-10% by mass percentage.
2. a kind of animal according to claim 1 core-shell structure zinc oxide clay antidiarrhoea formulation, it is characterised in that should
Preparation includes: zinc oxide 25%-50%, clay 20%-40%, enteric coating agents 1%-6% by mass percentage.
3. a kind of animal anti-abdomen of core-shell structure zinc oxide clay described in any one claim according to claim 1~2
Rush down preparation, it is characterised in that: clay is in montmorillonite, bentonite, concave convex rod, sepiolite, hectorite, vermiculite and kaolin
One or more of mixing.
4. a kind of animal according to claim 3 core-shell structure zinc oxide clay antidiarrhoea formulation, it is characterised in that: institute
The clay stated is selected from the mixing of montmorillonite, zeolite and bentonite one or more.
5. a kind of animal anti-abdomen of core-shell structure zinc oxide clay described in any one claim according to claim 1~2
Rush down preparation, it is characterised in that: the material of enteric coating is selected from shellac, Cellulose Acetate Phthalate, seaweed glue, polyvinyl alcohol vinegar
The mixing of one or more of sour phthalic acid ester, fatty acid, acrylic resin, hydroxypropyl methyl cellulose phthalate.
6. a kind of method for preparing preparation described in Claims 1 to 5 any one claim, it is characterised in that this method packet
Include following step:
1) suitable quantity of water is added in oxidisability powder, and the zinc oxide of required partial size and shape is caused in Granulation Equipments；
2) clay powder is added in zinc oxide core, and suitable quantity of water is added, clay powders are uniformly wrapped in zinc oxide core
Outer surface forms one layer of clay shell；
3) by spray or leaching technology, one layer of enteric-coating material is coated in zinc oxide clay particle surface；
4) sieving after particle drying is obtained into the formulation products.
7. the preparation method of preparation according to claim 6, it is characterised in that: step 1) is additionally added binder, binder
It is added in a manner of aqueous solution in oxidisability powder with water.
8. the preparation method of preparation according to claim 7, it is characterised in that: binder is starch, in gelatin, cyclodextrin
It is one or more.
9. the preparation method of preparation according to claim 6, it is characterised in that: the particle of formulation products is 10~80 mesh.
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| CN201611008158.9A CN106474151B (en) | 2016-11-16 | 2016-11-16 | A kind of animal core-shell structure zinc oxide clay antidiarrhoea formulation and preparation method thereof |
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| CN201611008158.9A CN106474151B (en) | 2016-11-16 | 2016-11-16 | A kind of animal core-shell structure zinc oxide clay antidiarrhoea formulation and preparation method thereof |
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| CN102335196A (en) * | 2011-10-25 | 2012-02-01 | 浙江大学 | Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method |
| CN104546908A (en) * | 2015-01-28 | 2015-04-29 | 成都乾坤动物药业有限公司 | Pharmaceutical composition as well as preparation method and application thereof |
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Denomination of invention: Core-shell structured zinc oxide clay anti-diarrhea preparation for animals and preparation method thereof Effective date of registration: 20200710 Granted publication date: 20190813 Pledgee: Zhejiang Anji Rural Commercial Bank of the West Branch of Limited by Share Ltd. Pledgor: ZHEJIANG FENGHONG NEW MATERIAL Co.,Ltd. Registration number: Y2020330000467 |
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Date of cancellation: 20220620 Granted publication date: 20190813 Pledgee: Zhejiang Anji Rural Commercial Bank of the West Branch of Limited by Share Ltd. Pledgor: ZHEJIANG FENGHONG NEW MATERIAL Co.,Ltd. Registration number: Y2020330000467 |
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