CN106421908A - 一种脱细胞角膜的制备方法 - Google Patents
一种脱细胞角膜的制备方法 Download PDFInfo
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- CN106421908A CN106421908A CN201610513270.1A CN201610513270A CN106421908A CN 106421908 A CN106421908 A CN 106421908A CN 201610513270 A CN201610513270 A CN 201610513270A CN 106421908 A CN106421908 A CN 106421908A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201610513270.1A CN106421908B (zh) | 2016-07-01 | 2016-07-01 | 一种脱细胞角膜的制备方法 |
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CN201610513270.1A CN106421908B (zh) | 2016-07-01 | 2016-07-01 | 一种脱细胞角膜的制备方法 |
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CN106421908A true CN106421908A (zh) | 2017-02-22 |
CN106421908B CN106421908B (zh) | 2018-01-16 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106938059A (zh) * | 2017-04-12 | 2017-07-11 | 山东省眼科研究所 | 一种体外构建组织工程角膜内皮的方法 |
CN109621009A (zh) * | 2018-11-27 | 2019-04-16 | 中国人民解放军总医院第附属医院 | 一种脱抗原肌腱处理方法 |
CN111686300A (zh) * | 2019-03-11 | 2020-09-22 | 广东博与再生医学有限公司 | 一种动物角膜组织的去细胞方法 |
CN111685101A (zh) * | 2019-03-11 | 2020-09-22 | 广东博与再生医学有限公司 | 一种用于脱细胞板层角膜的保存运输液 |
CN111840651A (zh) * | 2019-04-30 | 2020-10-30 | 广东博与再生医学有限公司 | 一种可快速修复受损组织的角膜移植材料及其制备方法 |
CN111840644A (zh) * | 2020-08-13 | 2020-10-30 | 镇江雷音再生医学科技有限公司 | 一种脱细胞人源角膜基质的制备方法 |
Citations (6)
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CN1579342A (zh) * | 2004-04-28 | 2005-02-16 | 浙江大学医学院附属邵逸夫医院 | 一种无细胞的异种角膜基质及制备方法和用途 |
CN1631138A (zh) * | 2004-11-15 | 2005-06-29 | 山东省眼科研究所 | 角膜中期保存液 |
CN101590292A (zh) * | 2009-06-11 | 2009-12-02 | 山东省眼科研究所 | 脱细胞结膜基质的制备方法和应用 |
US20110183404A1 (en) * | 2009-03-04 | 2011-07-28 | Snu R&Db Foundation | Method for processing porcine cornea for decellularization |
CN102470149A (zh) * | 2009-08-18 | 2012-05-23 | 生命细胞公司 | 用于处理组织的方法 |
CN104094925A (zh) * | 2014-07-18 | 2014-10-15 | 广州优得清生物科技有限公司 | 一种板层角膜保存液 |
-
2016
- 2016-07-01 CN CN201610513270.1A patent/CN106421908B/zh active Active
Patent Citations (6)
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CN1579342A (zh) * | 2004-04-28 | 2005-02-16 | 浙江大学医学院附属邵逸夫医院 | 一种无细胞的异种角膜基质及制备方法和用途 |
CN1631138A (zh) * | 2004-11-15 | 2005-06-29 | 山东省眼科研究所 | 角膜中期保存液 |
US20110183404A1 (en) * | 2009-03-04 | 2011-07-28 | Snu R&Db Foundation | Method for processing porcine cornea for decellularization |
CN101590292A (zh) * | 2009-06-11 | 2009-12-02 | 山东省眼科研究所 | 脱细胞结膜基质的制备方法和应用 |
CN102470149A (zh) * | 2009-08-18 | 2012-05-23 | 生命细胞公司 | 用于处理组织的方法 |
CN104094925A (zh) * | 2014-07-18 | 2014-10-15 | 广州优得清生物科技有限公司 | 一种板层角膜保存液 |
Non-Patent Citations (1)
Title |
---|
陈婴: "中长期保存的角膜内皮细胞超微结构的变化", 《现代医学》 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106938059A (zh) * | 2017-04-12 | 2017-07-11 | 山东省眼科研究所 | 一种体外构建组织工程角膜内皮的方法 |
CN106938059B (zh) * | 2017-04-12 | 2020-08-18 | 山东省眼科研究所 | 一种体外构建组织工程角膜内皮的方法 |
CN109621009A (zh) * | 2018-11-27 | 2019-04-16 | 中国人民解放军总医院第附属医院 | 一种脱抗原肌腱处理方法 |
CN109621009B (zh) * | 2018-11-27 | 2021-07-16 | 中国人民解放军总医院第四医学中心 | 一种脱抗原肌腱处理方法 |
CN111686300A (zh) * | 2019-03-11 | 2020-09-22 | 广东博与再生医学有限公司 | 一种动物角膜组织的去细胞方法 |
CN111685101A (zh) * | 2019-03-11 | 2020-09-22 | 广东博与再生医学有限公司 | 一种用于脱细胞板层角膜的保存运输液 |
CN111840651A (zh) * | 2019-04-30 | 2020-10-30 | 广东博与再生医学有限公司 | 一种可快速修复受损组织的角膜移植材料及其制备方法 |
CN111840651B (zh) * | 2019-04-30 | 2023-03-14 | 广东博与再生医学有限公司 | 一种可快速修复受损组织的角膜移植材料及其制备方法 |
CN111840644A (zh) * | 2020-08-13 | 2020-10-30 | 镇江雷音再生医学科技有限公司 | 一种脱细胞人源角膜基质的制备方法 |
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Inventor after: Shi Weiyun Inventor after: Zhou Qingjun Inventor after: Dong Muchen Inventor after: Qi Xia Inventor after: Zhang Ting Inventor before: Zhou Qingjun Inventor before: Wang Yao Inventor before: Duan Haoyun Inventor before: Yang Lingling |
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Effective date of registration: 20171212 Address after: The streets of Buji Gan Li Industrial Park of Longgang District, Shenzhen City, Guangdong province 518112 Gan Li six road No. 12 Hisense Science Park building first, block B, 101-102 Applicant after: Shenzhen Ainier Cornea Engineering Co., Ltd. Address before: 266071 Shandong province Qingdao city yanerdao Road No. 5 Applicant before: Specialty of Ophthalmology Research Institute, Shandong Prov |
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