CN106421793B - 用于治疗中枢介导的恶心及呕吐的组合物及方法 - Google Patents
用于治疗中枢介导的恶心及呕吐的组合物及方法 Download PDFInfo
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- CN106421793B CN106421793B CN201610795827.5A CN201610795827A CN106421793B CN 106421793 B CN106421793 B CN 106421793B CN 201610795827 A CN201610795827 A CN 201610795827A CN 106421793 B CN106421793 B CN 106421793B
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
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| PCT/IB2010/003106 WO2011061622A1 (en) | 2009-11-18 | 2010-11-18 | Compositions for treating centrally mediated nausea and vomiting |
| CN201610795827.5A CN106421793B (zh) | 2009-11-18 | 2010-11-18 | 用于治疗中枢介导的恶心及呕吐的组合物及方法 |
| CN2010800521070A CN102655864A (zh) | 2009-11-18 | 2010-11-18 | 用于治疗中枢介导的恶心及呕吐的组合物及方法 |
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| CN201510046972.9A Pending CN104856998A (zh) | 2009-11-18 | 2010-11-18 | 用于治疗中枢介导的恶心及呕吐的组合物及方法 |
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| ES2623503T3 (es) | 2009-11-18 | 2017-07-11 | Helsinn Healthcare Sa | Composiciones para tratar náuseas y vómitos mediados centralmente |
| EP2722045B1 (en) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions for treating centrally mediated nausea and vomiting |
| WO2013004766A1 (en) * | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
| CN105412110B (zh) * | 2011-10-18 | 2018-05-25 | 赫尔森保健股份公司 | 奈妥匹坦和帕洛诺司琼的治疗性组合 |
| US8426450B1 (en) * | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| US9403772B2 (en) | 2011-11-29 | 2016-08-02 | Helsinn Healthcare Sa | 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator |
| CN103520725B (zh) * | 2012-07-05 | 2017-10-24 | 海思科医药集团股份有限公司 | 一种治疗呕吐的药物组合物 |
| ES2824552T3 (es) | 2015-03-04 | 2021-05-12 | Vanda Pharmaceuticals Inc | Método de tratamiento con tradipitant |
| CN106902086B (zh) * | 2015-12-23 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种包含奈妥匹坦的固体组合物 |
| GB201618425D0 (en) * | 2016-11-01 | 2016-12-14 | Acacia Pharma Ltd | method |
| GB201702250D0 (en) | 2017-02-10 | 2017-03-29 | Acacia Pharma Ltd | Method |
| CN108721214B (zh) * | 2017-04-14 | 2020-06-16 | 和龙 | 奈妥吡坦和帕洛诺司琼复方纳米粒溶液、纳米粒及制备方法和用途 |
| CN108853010A (zh) * | 2017-05-15 | 2018-11-23 | 和龙 | 奈妥吡坦环糊精包合物、复方组合制剂及其制备方法和用途 |
| CN109200018A (zh) * | 2017-07-04 | 2019-01-15 | 南京诺瑞特医药科技有限公司 | 含有奈妥吡坦的微乳制剂 |
| CN119074729A (zh) * | 2017-11-17 | 2024-12-06 | 万达制药公司 | 使用川地匹坦治疗胃肠疾病的方法 |
| EP3746078A4 (en) * | 2018-02-02 | 2021-11-17 | Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro) | ORAL FORMULATIONS AND USES THEREOF |
| AU2021407138A1 (en) * | 2020-12-25 | 2023-06-29 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Use of nk1 antagonist prodrug compound in combination with 5-ht3 receptor antagonist |
| EP4385500A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Fixed dose combination comprising netupitant and palonosetron |
| WO2024126398A1 (en) | 2022-12-12 | 2024-06-20 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Fixed dose combination comprising netupitant and palonosetron |
| EP4633608A1 (en) | 2022-12-12 | 2025-10-22 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Antioxidant-free fixed dose combination of netupitant and palonosetron |
| EP4385497A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Antioxidant-free fixed dose combination of netupitant and palonosetron |
| WO2025246530A1 (en) * | 2024-05-30 | 2025-12-04 | The Chinese University Of Hong Kong | Personalized anti-emetic treatment for chemotherapy-induced nausea and vomiting |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1750822A (zh) * | 2003-02-18 | 2006-03-22 | 赫尔辛医疗股份公司 | 治疗术后恶心和呕吐的方法 |
| CN1767830A (zh) * | 2003-04-08 | 2006-05-03 | 普罗热尼奇制药公司 | 外周阿片拮抗剂具体是甲基纳曲酮治疗肠易激综合征的用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL166267B1 (pl) | 1989-11-28 | 1995-04-28 | Syntex Inc | Sposób wytwarzania nowych zwiazków trójpierscieniowych PL PL PL PL |
| US5510486A (en) | 1994-07-26 | 1996-04-23 | Syntex (U.S.A.) Inc. | Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one |
| US6297395B1 (en) | 1995-11-10 | 2001-10-02 | The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Calixarenes and their use for sequestration of metals |
| PT1035115E (pt) | 1999-02-24 | 2005-01-31 | Hoffmann La Roche | Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1 |
| MXPA03000366A (es) | 2000-07-14 | 2003-05-27 | Hoffmann La Roche | N-oxidos como profarmacos antagonistas del receptor nk1 de derivados de 4-fenil-piridina. |
| JP4116436B2 (ja) | 2000-12-14 | 2008-07-09 | エフ．ホフマン−ラ ロシュ アーゲー | 自己乳化脂質マトリックス（ｓｅｌｍ） |
| DE10393729T5 (de) | 2002-11-15 | 2005-10-13 | Helsinn Healthcare S.A. | Verfahren zur Behandlung von Emesis |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formulations of palonosetron |
| KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
| US7479312B2 (en) | 2005-07-07 | 2009-01-20 | Konica Minolta Opto, Inc. | Retardation film, polarizing plate, and liquid crystal display device |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| WO2007096763A2 (en) | 2006-02-23 | 2007-08-30 | Pfizer Limited | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines |
| KR101441459B1 (ko) | 2006-10-24 | 2014-09-18 | 헬신 헬쓰케어 에스.에이. | 안정성 및 생체이용률이 개선된 염산 팔로노세트론을 포함하는 연질 캡슐 |
| US20110014117A1 (en) * | 2007-06-28 | 2011-01-20 | Schering Corporation | Anti-igf1r |
| JP2011505873A (ja) * | 2007-12-18 | 2011-03-03 | シェーリング コーポレイション | 抗ｉｇｆ１ｒ療法に対する感受性のバイオマーカー |
| ES2623503T3 (es) | 2009-11-18 | 2017-07-11 | Helsinn Healthcare Sa | Composiciones para tratar náuseas y vómitos mediados centralmente |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1750822A (zh) * | 2003-02-18 | 2006-03-22 | 赫尔辛医疗股份公司 | 治疗术后恶心和呕吐的方法 |
| CN1767830A (zh) * | 2003-04-08 | 2006-05-03 | 普罗热尼奇制药公司 | 外周阿片拮抗剂具体是甲基纳曲酮治疗肠易激综合征的用途 |
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