CN106420554A - Anti-hair-loss nutrient liquid - Google Patents
Anti-hair-loss nutrient liquid Download PDFInfo
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- CN106420554A CN106420554A CN201610814229.8A CN201610814229A CN106420554A CN 106420554 A CN106420554 A CN 106420554A CN 201610814229 A CN201610814229 A CN 201610814229A CN 106420554 A CN106420554 A CN 106420554A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/002—Preparations for repairing the hair, e.g. hair cure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Abstract
The invention provides a cosmetic composition and in particular relates to nutrient liquid for preventing and treating hair loss. The anti-hair-loss nutrient liquid provided by the invention is prepared from a preservative, essence, pigment, a pH (Potential of Hydrogen) regulator and water, and also from (A) C12 to C14 fatty acid which accounts for 0.5 percent to 3 percent of the nutrient liquid in weight percent; (B) biotin which accounts for 0.1 percent to 0.5 percent of the nutrient liquid in weight percent; (C) caffeine which accounts for 0.05 percent to 1 percent of the nutrient liquid in weight percent; (D) a scalp nutrient regulator which accounts for 3 percent to 5 percent of the nutrient liquid in weight percent, wherein the scalp nutrient regulator is royal jelly compound essence; (E) vitamin E which accounts for 0.1 percent to 0.5 percent of the nutrient liquid in weight percent; (F) menthol which accounts for 0.05 percent to 0.5 percent of the nutrient liquid in weight percent; (G) D-panthenol which accounts for 0.1 percent to 0.8 percent of the nutrient liquid in weight percent; (H) polyoxyethylene 40 hydrogenated castor oil which accounts for 0.05 percent to 2 percent of the nutrient liquid in weight percent; (I) ethanol which accounts for 30 percent to 45 percent of the nutrient liquid in weight percent. The nutrient liquid contains active components including the fatty acid, group B vitamins, the caffeine and the like. The nutrient liquid disclosed by the invention is used for promoting the growth of hairs and reducing baldhead or hair loss.
Description
Technical field
The invention belongs to household chemicals field, the specially nutritional solution of a kind of prevention and process alopecia.
Background of invention
According to document, the growth cycle of hair is divided into trophophase (anagen), transition period (catagen)
And the common three phases of resting stage (telogen).The natural growth of hair comes from the root of hair, daily about 80-
100 hairs are dropped from scalp.80 to 100 is individual numerical range substantially, and more or less, or time length is all unlikely to draw
Send out fear.But when daily alopecia amount exceedes this normal range, a kind of irreversible or reversible alopecia phenomenon will
Occur, the generation of this phenomenon is relevant with the hair follicle of trophophase, and the hair follicle of trophophase is an organ with reactivity, non-
Chang Rongyi is affected by the interference of inside and outside physiology.Therefore, under naturalness, the first reaction of hair follicle is exactly to be rapidly switched to terminate
Phase state stops until interference effect, and the generation of interference cases starts from the minimizing of hair density until natural on-off cycles of hair growth initial stage head
Send out and drop, switch over and keep the amortization period state of hair follicle again until hair follicle is powerless.The reaction of hair follicle organ and interference
Without absolute relatedness between impact.
Reversible alopecia phenomenon is very universal, such as some fevers and digestion disease patient, and some diet are unbalanced
Or the people of monophagia, sideropenic patient in diet, diet lacks albumen, cancer patient or chemotherapy patients etc..In addition, alopecia is also sent out
Life is with the women in puerperal.A kind of gestagen, the hormone that a kind of period of gestation is generated in a large number, the hormone is with puerpera's head
The macrocyclic overall process of generation, before women's production, the hair of early growth period is very high with the hair ratio of growth amortization period, and gives birth to
After product, this ratio is just the opposite, illustrates that the hair of early growth period is converted to the hair of growth amortization period.After some months, and
The stage at natural on-off cycles of hair growth initial stage can be automatically switched to, and in the process, hair progressively falls light, and obvious bald spot is left on head.
Circulation another kind when the hair of new early growth period grows to certain length, before entering again.In addition, powerful spirit pressure
Power is another kind of reason of alopecia, not clear as alopecia mechanism, but can be it is clear that pressure energy causes human metabolism's work(
The disorder of energy, the operating of impact hair correlation organ dysfunction further.
Androgenetic bald () or alopecia, scalp sites hair follicle is started to shrink at and therefore produces the very little hair stage
Alopecia is to occupy a kind of most irreversible alopecias in traditional sense.This alopecia can occur earliest in the body of man that is only just of age
On, may also occur on the body of about 50 years old or so man.Two kinds of important androgens with biological activity play key
Effect such as testosterone and 5-a dihydrotestosterone.Testosterone can be converted into dihydrotestosterone by a kind of 5-a- reductase (being also testosterone reductase),
Dihydrotestosterone is the active hormone for affecting natural on-off cycles of hair growth.Let us say that, androgen occupies dictatorship in hormone family tree
Status, its natural on-off cycles of hair growth on head and body part can all produce impact.It will be appreciated, however, that male hormone is in the person
Body region and head position are contrary to the growth effect effect of hair.Male in puberty stage, when hair becomes from amortization period
When more to the hair stage being hardly visible, hair beard position can be facilitated to grow and produce the beard feature of male.Age is old
The alopecia of the people of some the mainly change comprising hair follicle, such as from hair amortization period to half amortization period again to the mistake of small hair follicle
Journey.Two stages can all cause the formation of the dispersibility alopecia of existing hair zones.
Content of the invention
It is an object of the invention to provide a kind of compositionss for causing hair healthy growth.The alopecia of said composition reversibility is obtained
Recover, the alopecia that especially androgen causes, terminate or avoid the generation of irreversible alopecia as far as possible.
The object of the present invention is achieved like this：A kind of hair anticreep nutritional solution, except containing preservative, essence, pigment, pH
Outside regulator, water, include：
(A) the C12-14 fatty acid of nutritional solution percentage by weight 0.5-3% is accounted for；
(B) biotin of nutritional solution percentage by weight 0.1-0.5% is accounted for；
(C) caffeine of nutritional solution percentage by weight 0.05-1% is accounted for；
(D) the scalp nutrition regulating agent of nutritional solution percentage by weight 3-5% is accounted for, and the scalp nutrition regulating agent is multiple for Lac regis apis
Close elite；
(E) vitamin E of nutritional solution percentage by weight 0.1-0.5% is accounted for；
(F) menthol of nutritional solution percentage by weight 0.05-0.5% is accounted for；
(G) D-panthenol of nutritional solution percentage by weight 0.1-0.8% is accounted for；
(H) Polyoxyl 40 Hydrogenated Castor Oil of percentage by weight 0.05-2% of the present invention is accounted for；
(I) ethanol of percentage by weight 30-45% of the present invention is accounted for.
The anticreep nutritional solution of the present invention, fatty acid therein is C12 fatty acid.
The consisting of of the anticreep nutritional solution of the present invention, wherein Lac regis apis elite：
A () accounts for the Mel of Lac regis apis elite percentage by weight 5-14%；
B () accounts for the propolis of Lac regis apis elite percentage by weight 0.5-2.5%；
C () accounts for the royal jelly extract of Lac regis apis elite percentage by weight 1-5%；
D () accounts for the butanediol of Lac regis apis elite percentage by weight 30-46%；
E () accounts for the glycerol of Lac regis apis elite percentage by weight 3-9%；
F () accounts for the coco-glucosides of Lac regis apis elite percentage by weight 3-6.9%；
The water of (g) and surplus.
Anticreep nutritional solution of the present invention, its pH value is between 4-5.5.
Advantages of the present invention：
The anticreep technological means science that anticreep nutritional solution of the present invention is adopted, comprehensively.Can neutralization, minimizing and counteracting initiation alopecia
Possible factor, prevent and prevent alopecia, promote recovery of the hair from reversibility alopecia state, be slowed or shut off hair not
The process of reversible alopecia.One maximum feature of anticreep nutritional solution of the present invention be can strengthen scalp and hair-care tensile force (hair
Intensity), being continuing to supply with auxiliary activity composition and nutrition is described, the blood circulation of head is accelerated, and hair peripheral organs obtain
The nutritional amt for obtaining is continuously increased, final hair tear resistance, hair toughness, and hair is resisted capability of influence of environment etc. and all obtained and adds
By force, therefore fastness of the hair on scalp is strengthened, and the quantity of alopecia is constantly reduced and stable in a quite reasonable level.
Description of the drawings
Fig. 1 is I type of male, II type and III type (bald) send out schematic diagram.IV, V, VI, VII point of I, II, III, III vertes of in figure
Not Biao Shi hair sparse or alopecia degree, and be divided into 7 ranks, the higher alopecia degree of rank is more serious.
Fig. 2 is I type of women, II type and III type (bald) send out schematic diagram.In figure crade I, crade II, crade III are respectively
Represent：Grade I is initial stage alopecia, feels unobvious；Grade II is mid-term alopecia, can be clearly felt that hair sparse, sends out
Capacity starts to reduce；Grade III is serious alopecia, and hair is very thin, and alopecia is obvious.
Specific embodiment
Make further general introduction below to the present invention.
Scientific research personnel is drawn by literature search and substantial amounts of experiment, a kind of include fatty acid, biotin, caffeine and
The compositionss of auxiliary activity composition prevent and prevent alopecia more more efficient than single-activity composition to promoting natural on-off cycles of hair growth.
According to the present invention, a kind of cosmetic composition, especially a kind of hair nutrition liquid, with preventing or at least reduce de-
Effect for sending out simultaneously is satisfied or fatty acid that unsaturated carbon atom number is 10 to 18 or its salt comprising (A) is at least one, (B) least one set
Effectively active substance is selected from vitamin and caffeine.
According to the present invention, a kind of method for being prevented and being processed alopecia using the above (A) and (B) compositionss is also this
A bright part.
Subject of the present invention also include a kind of strengthen hair grow naturally and reduce alopecia cosmetics method and comprising with
Lower step：A) suppress the effect of 5-a dihydrotestosterone, b) promote keratinization, c) strengthen blood supply and the battalion of hair organ sites
Support supply.
Active ingredient of the present invention includes that a kind of (A) carbon 10, to 18 fatty acid of carbon, is optimized for a kind of carbon 12 further to carbon 14
Fatty acid, final preferably 12 fatty acid of carbon；(B) biotin；(C) caffeine (1,3,7 trimethyl xanthine)；And other are auxiliary
Help active ingredient such as, assist blood supply accelerator includes tocopherol and its ester, nicotinic acid and its ester, nicotine (vitamin B5) is thin
Lotus alcohol, and the active matter with the effect of scalp nutrition adjustment.
After active compound of the present invention is applied, the biological activity of 5-a- reductase reduces or terminates, and then generates 5-a bis-
The amount of hydrogen testosterone (being had the hormone of direct correlation with alopecia) is also reduced therewith.Meanwhile, along with the continuous of auxiliary activity composition
Supply, the blood circulation of head is accelerated, and the nutritional amt that hair peripheral organs obtain is continuously increased.Final keratinization, tear resistance,
Hair toughness, hair is resisted capability of influence of environment etc. and all obtains reinforcement, and fastness of the hair on scalp is strengthened.The number of alopecia
Amount is constantly reduced and stable in a very low level.
Carbon 10 is to 18 fatty acid of carbon：In nutritional solution of the present invention, the content of fatty acid is weight percentage 0.01% to 10%,
Optimize and be weight percentage 0.5% to 3%.Fatty acid of the present invention includes saturation or undersaturated, side chain or non-branched fatty acid
Such as, octanoic acid, lauric acid, myristic acid, different myristic acid, Palmic acid, stearic acid, petroselic acid and its acceptable salt of cosmetics.This
Bright preferred carbon 12 to 14 fatty acid of carbon, especially moon silicic acid and myristic acid and its mixture, preferred 12 fatty acid of carbon of the present invention.Change
The acceptable salt of cosmetic includes alkali metal, alkaline-earth metal and ammonium salt.The salt-free fatty acid for existing under naturalness has more
High activity.
Biotin：In nutritional solution of the present invention, the content of biotin is weight percentage 0.05% to 1.2%, is optimized for weight
Percentage ratio 0.1% to 0.5%.Biotin is a part for B race compound vitamin, water solublity, also referred to as biotin, vitamin
B7, biotin (Coenzyme R) etc..Biotin Main Function is to aid in human body cell carbohydrate, fat and protein
Be converted to the energy that they can use.Biotin is used as nutritional supplement.Specify by China GB2760-90, can be used for food
Industry is used as processing aid.There are prevention dermatosiss, promote the physiological functions such as lipid metabolism.Eat raw albumen in a large number and may result in life
Thing element lacks.For cosmetics, speed of the blood circulation in skin heart can be improved,
Merge into Tetramethylene sulfide ring comprising ring urea (imidazolidine quinoline ketone) in biotin molecule structural formula of the present invention, valeric acid takes
The one of carbon atom bonding of Dai Jiyu Tetramethylene sulfide ring.Biotin is a kind of carboxylation
The coenzyme of enzyme, participates in fatty acid, isoleucine and Fig. 1
Azoles -4- valeric acid.See molecular formula 1
The quality of the application energy positive influences hair of biotin in the present invention, because biotin is cornified unit substantially
The supply of element, such as hair perienchyma biotin increases the keratinization that can improve hair perienchyma.Biotin especially strengthens head
The tensile toughness that sends out, tensile strength, and external environment impact and the effect of mechanical damage is resisted, so as to hair on scalp
Fastness is strengthened, and the quantity of alopecia is constantly reduced and stable in a very low level.
Caffeine：In nutritional solution of the present invention, the content of caffeine is weight percentage 0.005% to 5%, is optimized for weight
Percentage ratio 0.05% to 1%.Caffeine is a kind of plant alkaloid, belongs to purines, also referred to as caffeine.Methyl theobromine,
Garamine.Entitled 1,3,7 trimethyl xanthine of chemistry.This material contains in the middle of many plants, especially in coffee bean, black
Tea, Brazilian tea, can be satisfying, contain in cola etc..Caffeine has vasorelaxation action, and the blood that can increase hair organ is supplied
Give and nutrition supply, so as to extend the growth cycle of hair.
Solvent：The base solvent composition of nutritional solution of the present invention can be group water solution, alcohol-based solution or alcohol-water solution,
The present invention is selected from alcohol-water solution as solvent.Nutritional solution of the present invention can include low-carbon alcohols such as ethanol, and isopropanol and polyhydric alcohol are such as
Glycerol, diethylene glycol or Propylene Glycol.Low-carbon alcohols preferred alcohol of the present invention.Base solvent composition of the present invention is alcohol-water solution (ethanol
Aqueous solution).Nutritional solution of the present invention contains percentage by weight about 50% to 99% and is optimized for further containing percentage by weight about
83% to 96.95% solvent system.Ethanol of the present invention accounts for nutritional solution percentage by weight for 10% to 65%, is optimized for further
It is in the form of free acid and the pH value of nutritional solution to account for fatty acid in the nutritional solution of the present invention of nutritional solution weight 32% to 45%.
Between 3 to 7,4 to 6.5 are optimized for, re-optimization is 4.5-6.0.
Auxiliary active ingredient：Present invention auxiliary active ingredient is aided in into comprising having assosting effect such as vasodilation to hair growth promoting
Part or the active ingredient with blood supply facilitation, can strengthen the flowing of scalp vein blood so as to increase hair nutrition
Supply.
In nutritional solution of the present invention, auxiliary active ingredient is tocopherol (alpha-tocopherol, betatocopherol, Gamma-Tocopherol, δ-fertility
Phenol), the preferred alpha-tocopherol of the present invention and its esters such as vitamin E (tocopherol acetate), tocopherol succinate, tocopherol cigarette
Acid esters, or tocopheryl polyethylene glycol succinate；Nicotinic acid and its derivant, especially nicotiamide, methylnicotinic acid ester or tocopherol
Nicotinate；Auxiliary activity composition of the present invention also includes menthol, D-panthenol, the scalp nutrition anticreep tune with energy supply effect
Section agent, scalp nutrition anticreep regulator includes Lac regis apis composite essence, India's Ji extract, ocean glycogen complex, people
Ginseng anticreep composite reactive thing etc..Auxiliary activity composition preferred vitamin E of the present invention, D-panthenol, menthol and scalp nutrition are adjusted
Section agent.
Scalp nutrition regulating agent：Scalp nutrition regulating agent include Radix Ginseng extract, Radix Arctii extract, Indian Kino tree
The extract of bark, Mel, royal jelly extract.Radix Ginseng another name Sphallerocarpus gracilis, wooden club, Herba Wedeliae Wallichii, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), SHENCAO, Rhizoma Panacis Japonici,
Essence, sea fat, drawn grain are also red, Latin literary fame：Radix Ginseng Panax ginseng C.A.Mey, Araliaceae, Panax's perennial herb are planted
Thing, Radix Ginseng promotes cutaneous circulation containing multiple Saponins and polysaccharide constituents, Radix Ginseng extract energy skin expansion blood capillary,
Increase skin-nourishing, adjust the water and oil balance of skin.Radix Ginseng extract can make the telangiectasis of head in shampoo, can
Increase the nutrition of hair, the toughness of hair is improved, reduce alopecia, break and send out, to damaging hair, there is protective effect；Radix Arctii is called
Fructus Arctii, Fructus Arctii, Vespertilio thorn and Japan Radix Raphani.Seed and with being used as medicine.Burdock root system.Radix Arctii extract contain inulin,
Volatile oil, arctic acid, polyphenol substance and aldehydes, and rich cellulose and aminoacid.Fructus Arctii, the multiple nutrition containing needed by human body
Composition, with high health care and pharmacological function, with diuresis, under rushing down, effect (the Agriculture of Anhui science such as expansion of blood vessels
Sei.2010.38(33).18765-18767)；The lucky tree extract of India has antioxidation, the effect of defying age；Lac regis apis and
Mel has the effect for nourishing that scalp activates hair follicle；Ocean glycogen has supplementary scalp cells energy and excites scared capsule and napiform root
Cell is bred, and promotes the effect of natural on-off cycles of hair growth.
Scalp nutrition regulating agent of the present invention is selected from BASF AG's nutrition anticreep active substance, and scalp and hair follicle are supplemented
Multiple energies and trace element such as, Radix Ginseng anticreep composite reactive thing TRICHOGEN@VEG LS8960：Be by people's root extract,
May Radix Arctii extract, arginine, acetic acid L-Tyrosine, hydrolyzed soybean protein, polyquaternary ammonium salt -11, PEG-12 poly dimethyl silicon
Multiple work such as oxygen alkane, pantothenic acid, gluconic acid, nicotiamide, ornithine hcl 99, citrulline, glucosamine HCL, raw element H
Sexual element constitutes, and prevents, resists to fall, stimulating the effect of raw, raising degree with auxiliary；Ocean glycogen is combined
ThingGY contains trichogenous ocean glycogen active ingredient；The lucky tree extract of IndiaLS 9267, be a kind of tree, the i.e. bark extract of Indian Kino tree of rising in India of extraction simultaneously
Coordinate the L-Glutamic Acid of substrate and the disodium succinate synergism of cellular metabolism accelerator of cell effect, the anti-of scalp can be promoted
Aging.The youth of protection hair.Improve the thickness of hair；Lac regis apis composite essence Mellidyn LS 9834, by Mel, propolis
And royal jelly extract, butanediol, glycerol, coco-glucosides and water composition, wherein, Mel accounts for Lac regis apis composite essence weight hundred
Divide than 5-14%, propolis accounts for Lac regis apis composite essence percentage by weight 0.5-2.5%, and royal jelly extract accounts for Lac regis apis composite precision
Magnificent percentage by weight 1-5%, butanediol accounts for Lac regis apis composite essence percentage by weight 30-46%, and glycerol accounts for Lac regis apis composite precision
Magnificent percentage by weight 3-9%, coco-glucosides account for Lac regis apis composite essence percentage by weight 3-6.9%, balance of water.
Scalp nutrition regulating agent of the present invention preferably is selected from Lac regis apis composite essence.Lac regis apis composite essence accounts for nutritional solution of the present invention
Percentage by weight 1-8%, is optimized for 3-5% further.
Content of the auxiliary activity composition vitamin E of the present invention in nutritional solution of the present invention is weight percentage 0.05-1%,
Optimize and be weight percentage 0.1% to 0.5%；Content of the menthol in nutritional solution of the present invention is weight percentage 0.01-
0.8%, optimize the 0.05%-0.5% that is weight percentage；Content of the D-panthenol in nutritional solution of the present invention is weight percentage
0.05%-1%, optimizes the 0.1%-0.8% that is weight percentage.
The present invention also comprising cosmetically acceptable carrier such as, appropriate preservative, essence, pigment, pH adjusting agent, pH is adjusted
Save agent such as, citric acid, sodium citrate, preservative such as Sensiva SC50, methyl hydroxybenzoate, ethyl hydroxybenzoate；Account for weight of the present invention
Amount percentage ratio 0.05% to 2% Polyoxyl 40 Hydrogenated Castor Oil, and optimize be weight percentage 0.1% to 1% polyoxy
40 castor oil hydrogenated of ethylene；Composition with nursing role is as having the plant extract that skin protection or hair care are acted on, hydrolytic collagen
Albumen, fibroin, lanolin derivative；Silicone oil derivative such as volatility or non-volatile silicone oil, the siloxanes of high molecular gathers
Compound；Bright protective agent, antioxidant, free radical scavenger；Hair brightener, vitamin etc..
Nutritional solution of the present invention comprising using method such as, takes the hair nutrition liquid of q.s and on scalp, and uses finger tripe
Gently pat and massage is until absorbing.
The manufacture method of hair nutrition liquid of the present invention
1st, by lauryl alcohol, caffeine, biotin, D-panthenol, vitamin E, menthol is separately added into stirring and dissolving in ethanol
Stand-by.
2nd, will Polyoxyl 40 Hydrogenated Castor Oil add deionized water in dissolve, be subsequently adding in 1, and stir know molten
Solution.
3rd, scalp nutrition regulating agent * is added in 2, stirring and dissolving is known transparent.
4th, appropriate preservative, essence, pigment, pH adjusting agent are added.
Nutritional solution embodiment of the present invention is exemplified below
Embodiment I-V
* Lac regis apis composite essence Mellidyn LS 9834 (BASF), by Mel, propolis and royal jelly extract, fourth
Glycol, glycerol, coco-glucosides and water composition.
Embodiment VI-Ⅹ
* Lac regis apis composite essence Mellidyn LS 9834 (BASF), by Mel, propolis and royal jelly extract, fourth
Glycol, glycerol, coco-glucosides and water composition.
Efficacy test (study on the efficiency)
The effectiveness of nutritional solution of the present invention is realized by clinical research.Select one group of male subject 19, A (man)
Group, and one group of female subjects 20, A (female) group, two groups of experimenters of the men and women are respectively using nutritional solution of the present invention (embodiment Ⅹ
With embodiment VI)；At the same time, another group of male subject 18 selected, B (man) group, and one group of female subjects 19, B
(female) group, two groups of experimenters of the men and women are respectively using blank Example of the present invention (contrast 1 and contrast 2).Selected experimenter requires
II type of androgenetic bald () and III type is, sees Fig. 1 and Fig. 2.
The classification of bald ()
II type of androgenetic bald () and the definition of III type：
The definition of bald head.Bald head has two kinds of definition.One is typical male pattern baldness or androgenetic bald () (see Chinese Mill
Pause promise Wood classification method HamiltonNorwood Classification)；Two is women bald (), and women bald () adopts road
Classification method Ludwig classification is wished in Devi.
Male pattern baldness (is sent out)：
I type alopecia：Volume forward position no occurs or occurs that a small amount of hair line is recessed to move back phenomenon.
II type alopecia：The forward position hair line of frontal region domain hair has delta region to be formed, and extends back and external auditory meatus
Coronalplane forward position air line distance is less than 2 centimetres.
III type alopecia：Delta coronalplane described in II type alopecia is stretched again backward, apart from 2 lis of external auditory meatus forward position
Rice, this is identified as forming the minima of alopecia.
III type Vertex happens suddenly：Head has the hair sparse of small range or alopecia tendency：
IV type alopecia：Delta coronalplane described in III type alopecia is stretched again backward, and head has substantially little model
Enclose alopecia
V type alopecia：Delta coronalplane described in IV type alopecia is stretched again backward, is not also reached head and is taken off
The region that sends out, but head alopecia area expands further.
VI type alopecia：Delta coronalplane hair described in V type alopecia disappear and bald with head be linked togather,
And head alopecia area expands further compared with V type.
VII type alopecia：Its poll region large area is bald, only has hair at head temples.
Please see that I type, II type and III type are (bald) respectively and send out schematic diagram (Fig. 1)
Gynecoid type bald ()
Women alopecia adopts Ludwig classification method Ludwig classification
Women alopecia is conventional female alopecia evaluation methodology using Ludwig classification method, is broadly divided into Three Estate,
Grade I is initial stage alopecia, feels unobvious；Grade II is mid-term alopecia, can be clearly felt that hair sparse, sends out capacity and opens
Begin to reduce；Grade III is serious alopecia, and hair is very thin, and alopecia is obvious.
Please see I type, II type and III type alopecia schematic diagram (Fig. 2) respectively.
The quantity of measurement alopecia
Its timing node is set as t0:Using the alopecia quantity before nutritional solution；t45：After nutritional solution the 45th day
Alopecia quantity；t90：Using the alopecia quantity after nutritional solution the 90th day.Evaluation methodology is divided into and (being learned to do using section for objective evaluation
Section), subjective assessment (according to user individual evaluation) and quantitative measure (plug forwarding method).
Subjectivity and objective scoring about alopecia is divided into following grade
0：No alopecia
2：Slight alopecia
3-4：Moderate alopecia
6：Serious alopecia
Quantitative measurement about alopecia is measured according to the method for hair-plucking, i.e., in external ear 2-3 cm section, use
Thumb and forefinger grip the hair of a branch of about 60, are chosen the bundle hair (from root of hair to sending out a tip) with impartial finger strength, afterwards
The hair of flake-off is counted, epilation experiment is mainly loose number of hairs on measurement scalp, and by micro-
Sem observation is unplugged the situation of hair root and determines that hair is in trophophase or the state in amortization period.The method can be sentenced
The broken end species such as telogen effluvium sent out of loss of hairs, anagen effluvium, dry break to fall from root, androgen Asource alopecia, or office
Portion and alopecia generalisata etc..
Table 1
△(1)Hair drops the percentage ratio (meansigma methodss) of minimizing number
△(2)In scalp, loose hair reduces percentage ratio (meansigma methodss)
According to statistical analysiss, nutrition liquid energy of the present invention substantially reduces alopecia and significantly increases the tensile force of scalp and hair-care
(intensity of hair) illustrates being continuing to supply with auxiliary activity composition and nutrition, and the blood circulation of head is accelerated, hair periphery
The nutritional amt of Organ procurement is continuously increased.Final hair tear resistance, hair toughness, hair resists capability of influence of environment etc. all
It is that fastness of the hair on scalp is strengthened to obtain reinforcement.The quantity of alopecia is constantly reduced and stable in a very low level.
Claims (4)
1. a kind of hair anticreep nutritional solution, in addition to containing preservative, essence, pigment, pH adjusting agent, water, includes：
(A) C of nutritional solution percentage by weight 0.5-3% is accounted for12-14Fatty acid；
(B) biotin of nutritional solution percentage by weight 0.1-0.5% is accounted for；
(C) caffeine of nutritional solution percentage by weight 0.05-1% is accounted for；
(D) the Lac regis apis composite essence nutrition regulating agent of nutritional solution percentage by weight 3-5% is accounted for；
(E) vitamin E of nutritional solution percentage by weight 0.1-0.5% is accounted for；
(F) menthol of nutritional solution percentage by weight 0.05-0.5% is accounted for；
(G) D-panthenol of nutritional solution percentage by weight 0.1-0.8% is accounted for；
(H) Polyoxyl 40 Hydrogenated Castor Oil of nutritional solution percentage by weight 0.05-2% is accounted for；
(I) ethanol of nutritional solution percentage by weight 30-45% is accounted for.
2. anticreep nutritional solution according to claim 1, fatty acid therein be12Fatty acid.
3. the consisting of of anticreep nutritional solution according to claim 1, wherein Lac regis apis elite：
A () accounts for the Mel of Lac regis apis elite percentage by weight 5-14%；
B () accounts for the propolis of Lac regis apis elite percentage by weight 0.5-2.5%；
C () accounts for the royal jelly extract of Lac regis apis elite percentage by weight 1-5%；
D () accounts for the butanediol of Lac regis apis elite percentage by weight 30-46%；
E () accounts for the glycerol of Lac regis apis elite percentage by weight 3-9%；
F () accounts for the coco-glucosides of Lac regis apis elite percentage by weight 3-6.9%；
The water of (g) and surplus.
4. the anticreep nutritional solution according to claim 1-3, its pH value is between 4-5.5.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692030A (en) * | 2017-03-14 | 2017-05-24 | 福建省神蜂科技开发有限公司 | Propolis shampoo capable of preventing hair loss |
| CN107157804A (en) * | 2017-07-19 | 2017-09-15 | 广东德丝肤生物科技有限公司 | A kind of nutrition scalp hair follicles hair tonic elite and preparation method thereof |
| CN107349163A (en) * | 2017-07-19 | 2017-11-17 | 广东德丝肤生物科技有限公司 | A kind of nutrition hair follicle strengthen the hair dark hair elite and preparation method thereof |
| CN109172477A (en) * | 2018-09-26 | 2019-01-11 | 明辉实业（深圳）有限公司 | A kind of anti-deactivation hair compounding factor, anti-deactivation hair essence and preparation method thereof |
| CN111228172A (en) * | 2020-01-16 | 2020-06-05 | 辉达生物医药（苏州）有限公司 | High-efficiency hair loss prevention and hair growth composition |
| CN114796054A (en) * | 2022-05-13 | 2022-07-29 | 广州市科能化妆品科研有限公司 | Anti-hair loss scalp care composition and preparation method and application thereof |
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| US20020034485A1 (en) * | 2000-07-22 | 2002-03-21 | Friedrich Noser | Hair tonic for prevention or treatment of hair loss |
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Patent Citations (1)
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| US20020034485A1 (en) * | 2000-07-22 | 2002-03-21 | Friedrich Noser | Hair tonic for prevention or treatment of hair loss |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692030A (en) * | 2017-03-14 | 2017-05-24 | 福建省神蜂科技开发有限公司 | Propolis shampoo capable of preventing hair loss |
| CN107157804A (en) * | 2017-07-19 | 2017-09-15 | 广东德丝肤生物科技有限公司 | A kind of nutrition scalp hair follicles hair tonic elite and preparation method thereof |
| CN107349163A (en) * | 2017-07-19 | 2017-11-17 | 广东德丝肤生物科技有限公司 | A kind of nutrition hair follicle strengthen the hair dark hair elite and preparation method thereof |
| CN109172477A (en) * | 2018-09-26 | 2019-01-11 | 明辉实业（深圳）有限公司 | A kind of anti-deactivation hair compounding factor, anti-deactivation hair essence and preparation method thereof |
| CN111228172A (en) * | 2020-01-16 | 2020-06-05 | 辉达生物医药（苏州）有限公司 | High-efficiency hair loss prevention and hair growth composition |
| CN114796054A (en) * | 2022-05-13 | 2022-07-29 | 广州市科能化妆品科研有限公司 | Anti-hair loss scalp care composition and preparation method and application thereof |
| CN114796054B (en) * | 2022-05-13 | 2023-10-20 | 广州市科能化妆品科研有限公司 | Hair loss prevention scalp care composition, and preparation method and application thereof |
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Application publication date: 20170222 |