CN106414458B - 新型稠合咪唑并苯并噻唑化合物 - Google Patents

新型稠合咪唑并苯并噻唑化合物 Download PDF

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Publication number
CN106414458B
CN106414458B CN201580024068.6A CN201580024068A CN106414458B CN 106414458 B CN106414458 B CN 106414458B CN 201580024068 A CN201580024068 A CN 201580024068A CN 106414458 B CN106414458 B CN 106414458B
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China
Prior art keywords
imidazo
tert
butyl
pyrazol
amino
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Expired - Fee Related
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CN201580024068.6A
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English (en)
Chinese (zh)
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CN106414458A (zh
Inventor
潘利克·欣德
桑贾伊·斯里瓦斯塔瓦
达温德·图利
迪帕克·拉伊
普拉尚特·哥吉
沙伊莱什·德什潘德
拉姆谢金德尔·古普塔
维贾伊·乔泰瓦利
海坦亚·杜特
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Torrent Pharmaceuticals Ltd
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Torrent Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
CN201580024068.6A 2014-03-27 2015-03-24 新型稠合咪唑并苯并噻唑化合物 Expired - Fee Related CN106414458B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1089MU2014 2014-03-27
IN1089/MUM/2014 2014-03-27
PCT/IB2015/052124 WO2015145336A1 (en) 2014-03-27 2015-03-24 Novel fused imidazobenzothiazole compounds

Publications (2)

Publication Number Publication Date
CN106414458A CN106414458A (zh) 2017-02-15
CN106414458B true CN106414458B (zh) 2019-10-29

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CN201580024068.6A Expired - Fee Related CN106414458B (zh) 2014-03-27 2015-03-24 新型稠合咪唑并苯并噻唑化合物

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US (2) US9908898B2 (enExample)
EP (1) EP3122755B1 (enExample)
JP (1) JP6480949B2 (enExample)
KR (1) KR102339610B1 (enExample)
CN (1) CN106414458B (enExample)
AR (1) AR099867A1 (enExample)
AU (1) AU2015237840B2 (enExample)
CA (1) CA2943098C (enExample)
CY (1) CY1121147T1 (enExample)
DK (1) DK3122755T3 (enExample)
EA (1) EA029745B9 (enExample)
ES (1) ES2707099T3 (enExample)
HR (1) HRP20190121T1 (enExample)
HU (1) HUE042493T2 (enExample)
IL (1) IL247955B (enExample)
LT (1) LT3122755T (enExample)
MX (1) MX368985B (enExample)
MY (1) MY193041A (enExample)
PH (1) PH12016501903B1 (enExample)
PL (1) PL3122755T3 (enExample)
PT (1) PT3122755T (enExample)
RS (1) RS58324B1 (enExample)
SG (1) SG11201607793RA (enExample)
SI (1) SI3122755T1 (enExample)
SM (1) SMT201900036T1 (enExample)
TR (1) TR201900735T4 (enExample)
TW (1) TWI648282B (enExample)
UA (1) UA121469C2 (enExample)
WO (1) WO2015145336A1 (enExample)
ZA (1) ZA201606598B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX379228B (es) 2013-03-15 2025-03-10 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulación de la hemoglobina.
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
TWI648282B (zh) * 2014-03-27 2019-01-21 印度商托仁特生技有限公司 新熔合咪唑苯并噻唑化合物
DE102016209204A1 (de) 2016-05-27 2017-11-30 Robert Bosch Gmbh Vorrichtung zur Regelung mindestens eines Fluidstroms in einem Fahrzeug
KR102630959B1 (ko) * 2016-10-31 2024-01-29 엘지디스플레이 주식회사 유기 화합물과 이를 이용한 발광다이오드 및 유기발광다이오드 표시장치
CN106727538A (zh) * 2017-02-20 2017-05-31 潘连香 一种治疗2型糖尿病的药物组合物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2211186A (en) * 1987-10-20 1989-06-28 Roussel Lab Ltd Chemical compounds
GB2232666B (en) * 1989-04-19 1992-09-30 Roussel Lab Ltd Imidazobenzthiazoles
WO1995029922A1 (en) * 1994-04-29 1995-11-09 Pharmacia & Upjohn Company Methanol derivatives for treatment of retroviral infections especially hiv infections
WO2002014321A1 (en) * 2000-08-11 2002-02-21 The Regents Of The University Of California Use of stat-6 inhibitors as therapeutic agents
US20060122178A1 (en) * 2001-06-26 2006-06-08 Cottam Howard B Compounds having activity as inhibitors of apoptosis
WO2007091152A1 (en) * 2006-02-09 2007-08-16 Pfizer Limited Triazolopyridine compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0316506A (pt) * 2002-11-25 2005-10-04 Pharmacia Corp Midas e ácidos heteroarilsulfonilmetil hidroxâmicos e sua aplicação como inibidores da protease
GB0320244D0 (en) * 2003-05-06 2003-10-01 Aventis Pharma Inc Pyrazoles as inhibitors of tumour necrosis factor
TWI648282B (zh) * 2014-03-27 2019-01-21 印度商托仁特生技有限公司 新熔合咪唑苯并噻唑化合物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2211186A (en) * 1987-10-20 1989-06-28 Roussel Lab Ltd Chemical compounds
GB2232666B (en) * 1989-04-19 1992-09-30 Roussel Lab Ltd Imidazobenzthiazoles
WO1995029922A1 (en) * 1994-04-29 1995-11-09 Pharmacia & Upjohn Company Methanol derivatives for treatment of retroviral infections especially hiv infections
WO2002014321A1 (en) * 2000-08-11 2002-02-21 The Regents Of The University Of California Use of stat-6 inhibitors as therapeutic agents
US20060122178A1 (en) * 2001-06-26 2006-06-08 Cottam Howard B Compounds having activity as inhibitors of apoptosis
WO2007091152A1 (en) * 2006-02-09 2007-08-16 Pfizer Limited Triazolopyridine compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial;William MacNee，等;《Thorax》;20130411;第00卷;第1-8页 *
Models of chronic obstructive pulmonary disease;David A Groneberg，等;《Respiratory Research》;20041102;第5卷(第18期);第1-16页 *

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Publication number Publication date
AR099867A1 (es) 2016-08-24
SMT201900036T1 (it) 2019-02-28
MY193041A (en) 2022-09-23
KR102339610B1 (ko) 2021-12-14
CN106414458A (zh) 2017-02-15
PH12016501903A1 (en) 2017-01-09
MX2016012535A (es) 2017-05-04
SI3122755T1 (sl) 2019-02-28
IL247955A0 (en) 2016-11-30
US20170107233A1 (en) 2017-04-20
MX368985B (es) 2019-10-23
US10227361B2 (en) 2019-03-12
UA121469C2 (uk) 2020-06-10
EA201691920A1 (ru) 2017-01-30
PH12016501903B1 (en) 2019-04-26
TR201900735T4 (tr) 2019-02-21
ZA201606598B (en) 2017-11-29
LT3122755T (lt) 2019-02-11
KR20160129089A (ko) 2016-11-08
IL247955B (en) 2021-02-28
HUE042493T2 (hu) 2019-07-29
AU2015237840B2 (en) 2019-06-20
HRP20190121T1 (hr) 2019-03-08
CA2943098C (en) 2022-07-05
TWI648282B (zh) 2019-01-21
JP6480949B2 (ja) 2019-03-13
US9908898B2 (en) 2018-03-06
CY1121147T1 (el) 2020-05-29
EP3122755A1 (en) 2017-02-01
TW201613941A (en) 2016-04-16
NZ724342A (en) 2021-02-26
WO2015145336A1 (en) 2015-10-01
CA2943098A1 (en) 2015-10-01
US20180127437A1 (en) 2018-05-10
EA029745B1 (ru) 2018-05-31
ES2707099T3 (es) 2019-04-02
EP3122755B1 (en) 2018-11-07
DK3122755T3 (en) 2019-02-18
PL3122755T3 (pl) 2019-05-31
SG11201607793RA (en) 2016-10-28
RS58324B1 (sr) 2019-03-29
PT3122755T (pt) 2019-01-30
JP2017513825A (ja) 2017-06-01
EA029745B9 (ru) 2018-08-31
AU2015237840A1 (en) 2016-09-29

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