CN106413693A - 包含部分中和的酯化纤维素醚的分散体 - Google Patents
包含部分中和的酯化纤维素醚的分散体 Download PDFInfo
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- CN106413693A CN106413693A CN201580027167.XA CN201580027167A CN106413693A CN 106413693 A CN106413693 A CN 106413693A CN 201580027167 A CN201580027167 A CN 201580027167A CN 106413693 A CN106413693 A CN 106413693A
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- cellulose ether
- esterified cellulose
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- cooh
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- 239000000203 mixture Substances 0.000 claims abstract description 102
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract description 70
- 239000002775 capsule Substances 0.000 claims abstract description 54
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract description 35
- 235000019253 formic acid Nutrition 0.000 claims abstract description 35
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- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 4
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 description 4
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- 229910001414 potassium ion Inorganic materials 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
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- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- UWHZIFQPPBDJPM-BQYQJAHWSA-N trans-vaccenic acid Chemical compound CCCCCC\C=C\CCCCCCCCCC(O)=O UWHZIFQPPBDJPM-BQYQJAHWSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462000709P | 2014-05-20 | 2014-05-20 | |
US62/000709 | 2014-05-20 | ||
PCT/US2015/027863 WO2015179072A1 (en) | 2014-05-20 | 2015-04-28 | Dispersion comprising a partially neutralized esterified cellulose ether |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106413693A true CN106413693A (zh) | 2017-02-15 |
CN106413693B CN106413693B (zh) | 2018-08-24 |
Family
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Family Applications (1)
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EP (1) | EP3145498B1 (zh) |
JP (1) | JP6190078B2 (zh) |
KR (1) | KR20170005833A (zh) |
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EP2844296B1 (en) | 2012-05-02 | 2019-03-13 | Capsugel Belgium NV | Aqueous dispersions of hydroxypropyl methylcellulose acetate succinate (hpmcas) |
US20160256399A1 (en) | 2013-11-04 | 2016-09-08 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
CN107849152B (zh) * | 2015-07-28 | 2020-12-01 | 陶氏环球技术有限责任公司 | 生产酯化纤维素醚分散体的方法 |
BR112018073210A2 (pt) | 2016-05-25 | 2019-04-16 | Dow Global Technologies Llc | solução aquosa de acetato de éter de celulose |
JP6683561B2 (ja) | 2016-07-12 | 2020-04-22 | 信越化学工業株式会社 | 腸溶性硬カプセル用組成物及び腸溶性硬カプセルの製造方法 |
EP3272340A1 (en) * | 2016-07-22 | 2018-01-24 | Capsugel Belgium NV | Acid resistant capsules |
US20210115161A1 (en) * | 2017-03-17 | 2021-04-22 | Dow Global Technologies Llc | Process for Recovering an Esterified Cellulose Ether from a Reaction Product Mixture |
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WO2015179072A1 (en) | 2015-11-26 |
CN106413693B (zh) | 2018-08-24 |
JP6190078B2 (ja) | 2017-08-30 |
EP3145498B1 (en) | 2020-03-04 |
KR20170005833A (ko) | 2017-01-16 |
JP2017515944A (ja) | 2017-06-15 |
US10179110B2 (en) | 2019-01-15 |
EP3145498A1 (en) | 2017-03-29 |
US20170181977A1 (en) | 2017-06-29 |
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