CN106389838A - Traditional Chinese medicine for treating elderly hypertension - Google Patents
Traditional Chinese medicine for treating elderly hypertension Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine for treating elderly hypertension, and belongs to the technical field of traditional Chinese medicine preparations for treating hypertension. The traditional Chinese medicine for treating the elderly hypertension is prepared from the following raw materials in parts by weight: 8 to 30 parts of radix astragali seu hedysari, 4 to 30 parts of rhizoma polygonati, 4 to 30 parts of herba taxilli, 4 to 30 parts of fructus ligustri lucidi, 3 to 10 parts of radix cyathulae, 4 to 30 parts of rhizoma alismatis, 4 to 30 parts of cortex eucommiae, 2 to 8 parts of rhizoma chuanxiong, 2 to 8 parts of radix saposhnikoviae, 1 to 6 parts of hirudo and 2 to 8 parts of ramulus uncariae cum uncis. The traditional Chinese medicine disclosed by the invention has the effects of tonifying kidney qi and activating blood, is suitable for diseases of hypertension, kidney qi deficiency and blood stasis, is particularly suitable for a patient suffering from the elderly hypertension and has no toxic and side effects, the production technology is simple, and product quality is convenient to control.
Description
Technical field
The present invention relates to a kind of Chinese medicine treating senile hypertension, belong to the technical field of traditional Chinese medicine preparation for the treatment of hypertension.
Background technology
With the arrival of China human mortality aging, Chronic Non-Communicable Diseasess have become the master threatening population health and life
Want disease.Hypertension is apoplexy, the important risk factor of myocardial infarction, heart failure and chronic nephropathy chronic diseases.At present
25%～35% is had to be hyperpietic in whole world adult, hyperpietic's sum reaches 9.72 hundred million, and in more than 70 years old crowd
Then rise to 60%～70%.China is used for just up to 36,600,000,000 yuan of the medical care expenses of hypertension every year.As the sickness rate highest heart
One of angiopathy, hypertension has constituted the heavy burden of Chinese society, and its ascendant trend is effectively controlled not yet.
Often systolic pressure height but the high or even not low problem of diastolic pressure, the hyperpietic of more than 60 years old in senile hypertension
In have 2/3 be isolated systolic hypertension.Often therewith and a concept seeing is the difference of pulse pressure systolic pressure and diastolic pressure,
Normally should be in the range of 30～40 millimetress of mercury, its increase is an index of arteriosclerosis.2010 editions hypertension of China are prevented
Control guide to point out, it is one of clinical characters of senile hypertension that pulse pressure increases, and pulse pressure with general mortality rate and cardiovascular event is in
Substantially positive correlation.The high or even not low senile patients with isolated systolic hypertension of diastolic pressure, application guide for systolic pressure height
The five big class antihypertensive drugs recommended：Calcium antagonist, diuretic, beta-blocker, angiotensin converting enzyme inhibitor, blood vessel
Angiotensin Ⅱ receptor blocking agent, but while reducing systolic pressure, diastolic pressure also can reduce, if blood pressure lowering is in fact it could happen that shrink simply
When pressure is not yet down to the achievement level of 150 millimetress of mercury, diastolic pressure, already below this NLL of 60 millimetress of mercury, is more easy to draw
Make up one's mind, the ischemic lesions of the important organ such as brain, but current chemicalses cannot solve this difficult problem, and the high blood of western medicine
Although pressure disease instant effect, hypotensive effect are stronger, there are many problems, if any certain side effect, pressure reduction blood pressure
Fluctuation is larger, be discontinued after easily bounce-back etc..Relative although Chinese medicine for lowering high blood pressure to be not so good as Western medicine instant effect, effect strong, but safer,
Stable, the medicine tool finding effectively preventing hypertension therefore from this treasure-house of Chinese medicine is of great significance.
The traditional Chinese medical science passes through dialectical treatmert, prescribes for a complaint, and is showed as the main side's of condemning medication using the current disease of patient, rather than
Single with pressure value for medication reference, from this angle analysis, systolic pressure is high and numerical value contradiction that diastole is forced down not direct shadow
Ring Chinese medical discrimination and prescription.The contradictory phenomena that old people's systolic pressure is high, diastole is forced down only shows that patient is in itself negative and positive and loses
Go the state balancing, can not effectively being adjusted.The traditional Chinese medical science focuses on organic conception, and human body itself is an entirety, has self
The function of adjustment, Chinese traditional medical diagnose is to assist human body to carry out overall conditioning with medicine, corrects the inclined victory of internal organs negative and positive or partially declines, removes
The pathological factors such as expectorant is turbid, blood stasis, make yin-Yang restore balance, or tend to balance.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine treating senile hypertension, it has the work(of the kidney invigorating gas and blood vessels
Effect, it is adaptable to hypertension kidney qi virtual loss, blood-vessel obstructive disease, can improve hyperpietic's dizziness headache, Hiccough and deaf, memory
Go down, asthenia is drowsiness, neither cold-resistant and thermo-labile, the loss of hairs that turns white, luxated tooth are early de-, soreness of the waist and knees, frequent micturition, frequent urination at night, tongue
Matter is purple dark or has the symptoms such as petechia ecchymosis, especially suitable aged patients with hypertension, has no toxic side effect, simple production process, product
Quality is easy to control.
The Chinese medicine for the treatment of senile hypertension of the present invention, including the raw material of following parts by weight：Radix Astragali 8-30 part, Huang
Smart 4-30 part, parasitic 4-30 part, Fructus Ligustri Lucidi 4-30 part, Radix Cyathulae 3-10 part, Rhizoma Alismatis 4-30 part, Cortex Eucommiae 4-30 part, Rhizoma Chuanxiong 2-8
Part, Radix Saposhnikoviae 2-8 part, Hirudo 1-6 part, Ramulus Uncariae Cum Uncis 2-8 part.
Preferably, including the raw material of following parts by weight：8 parts of the Radix Astragali, 4 parts of Rhizoma Polygonati, 4 parts of parasitism, 4 parts of Fructus Ligustri Lucidi, river cattle
3 parts of knee joint, 8 parts of Rhizoma Alismatis, 4 parts of the Cortex Eucommiae, 2.7 parts of Rhizoma Chuanxiong, 2.7 parts of Radix Saposhnikoviae, 1.6 parts of Hirudo, 2.7 parts of Ramulus Uncariae Cum Uncis.
Preferably, including the raw material of following parts by weight：16 parts of the Radix Astragali, 5 parts of Rhizoma Polygonati, 5 parts of parasitism, 10 parts of Fructus Ligustri Lucidi, river
5 parts of Radix Achyranthis Bidentatae, 4 parts of Rhizoma Alismatis, 5 parts of the Cortex Eucommiae, 3 parts of Rhizoma Chuanxiong, 5.4 parts of Radix Saposhnikoviae, 3.2 parts of Hirudo, 5.4 parts of Ramulus Uncariae Cum Uncis.
Preferably, including the raw material of following parts by weight：12 parts of the Radix Astragali, 10 parts of Rhizoma Polygonati, 10 parts of parasitism, 4 parts of Fructus Ligustri Lucidi, river
10 parts of Radix Achyranthis Bidentatae, 8 parts of Rhizoma Alismatis, 10 parts of the Cortex Eucommiae, 6 parts of Rhizoma Chuanxiong, 5.4 parts of Radix Saposhnikoviae, 3.2 parts of Hirudo, 5.4 parts of Ramulus Uncariae Cum Uncis.
The preparation method of described Chinese medicine is customary preparation methods, and dosage form is oral liquid, tablet, capsule or granule.
The pharmacology analysis of the described Chinese medicine for the treatment of senile hypertension：
The Radix Astragali：Sweet tepor, return lung spleen channel,《This warp》Call its work(specially " qi-restoratives ",《Mingyi Bielu》Carry its main " QI invigorating ",《Medicine
Property opinion》Then the Radix Astragali " interior benefit, main renal failure " is proposed,《The Decoction and Material Medica》Especially emphasize the Radix Astragali " and the dirty vigour of the kidney invigorating "；Rhizoma Polygonati：Gan Ping,
Returns spleen lung kidney channel, both can the kidney invigorating gas, again be apt to replenishing essence marrow,《The southern regions of the Yunnan Province book on Chinese herbal medicine》Call its can " qi-restoratives adds essence ",《Compendium of Materia Medica》Carry its energy
" mending all void, replenishing essence marrow ",《This is former through meeting》Then call its can " alleviating distention in middle-JIAO QI invigorating, make the five internal organs be in harmonious proportion, muscle sufficiency, bone marrow is hard by force, is all
The work(of nourishing YIN "；With parasitic compatibility, Zishen fill fine, tonification kidney power；Parasitism, bitter sweet is put down, invigorating the liver and kidney, except wind and removing obstruction in channels,《This is former through meeting》
Point out " residual air of parasitic Mulberry and give birth to, the special wind-dispelling of property is by wet, logical blood circulation regulating ",《Book on Chinese herbal medicine is looked for the truth》It " is called that kidney tonifying and enriching blood will
Agent ", is matched with the Radix Astragali, Rhizoma Polygonati, strengthens the power of the kidney invigorating, and the work(of long memorial wind and network, shares as monarch.
On the basis of tonifying Qi of the kidney, follow the prescription objective of " control blood and first control wind, wind goes blood certainly to lead to ", cooperation in treatment again
The Rhizoma Chuanxiong of pungent-warm, activating QI to alleviate the depression, expelling wind and activating blood circulation pain relieving,《This warp》Carry its " main apoplexy enters brain headache ",《Japan hanako materia medica》Call it
Can " control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjust many arteries and veins, broken crux, stagnated blood, foster fresh blood ",
《Compendium of Materia Medica》Its main " activating QI to alleviate the depression " is proposed,《Amplification on Materia Medica》Point out " head wind can not fault ", Li Gao then points out " headache palpus
With Rhizoma Chuanxiong ",《Book on Chinese herbal medicine is just》Comment：" Rhizoma Chuanxiong, its property is apt to dissipate, and walks Liver Channel, the blood medicine in gas again.Rhizome of chuanxiong dissipate dynamic more so in returning,
Therefore energy dispersing wind and cold, control headache, removing blood stasis with potent drugs stores, promoting blood circulation.”《Collected statements on the herbal foundation》Also cloud：" the up head, lower regulating menstruation water, middle relieving stagnation,
Gas medicine in blood, tastes and is made by Radix Angelicae Sinensis.Fei Zhi blood is active, and also god tests to control gas." work(of common long memorial wind and network with monarch drug parasitism
Effect；Cooperation Radix Saposhnikoviae, Xin Ganwen, return bladder, lung, spleen channel, function delivers wind-dispelling, removing dampness to relieve pain,《This warp》Meaning gas " main big dizziness due to wind
Bitterly ",《Japan hanako materia medica》Carry it and " wind as 36, invigorating middle warmer benefit, tonneau the five internal organs GUAN-pulse can be controlled ",《Medicine class on the analogy of natural things》It is claimed " to control wind
General ", Li Gao emphasizes " Radix Saposhnikoviae be in expelling wind drug profit agent ", both can strengthen Rhizoma Chuanxiong, parasitic dispelling wind dredging collateral, thoroughly reach the power of malicious heresy, and
Wet dry product consumption impairment of body fluid liquid can be prevented；Compatibility Fructus Ligustri Lucidi, bitter in the mouth, flat, return liver and kidney channel, function the liver benefiting kidney yin, improving eyesight,《This warp》
Call its " main invigorating middle warmer, settling five organs support spirit, except hundred diseases "；The Cortex Eucommiae, sweet micro-pungent, temperature, Return liver kidney channel, function invigorating the liver and kidney, bone and muscle strengthening,
《This warp》Call its " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones, Qiang Zhi, the strong will of invigorating middle warmer, strong kidney adds essence,《Beautiful Chinese catalpa medicine solution》Call it
" two medicines and monarch drug share for liver and kidney tonifying, nourishing muscle and tendon bone, mend and not dry, flat invigorating the liver and kidney；Again compatibility is sweet trembles with fear into the Rhizoma Alismatis of kidney, diuretic, oozes
Wet, expel the heat-evil,《This warp》Call its main " disappear water, foster the five internal organs, physical strength profiting ",《Japan hanako materia medica》Cloud its " main head rotation, ear tinnitus of deficiency type ",《Doctor
Open source》Then " old water can be removed, support new water ",《Compendium of Materia Medica》Meaning " Rhizoma Alismatis have foster the five internal organs, physical strength profiting, control head rotation, clever knowledge it
Work(", and Rhizoma Polygonati, Radix Astragali compatibility, the kidney invigorating is empty, lets out that kidney is turbid, can drop and let out asthenia of renal qi disturbance in functioning of QI and stop poly- turbid damp, can restrict again
Warm-dryness syndrome all medicines thermal burn Tianjin and dissipate medicine consumption and hinder the disadvantage of healthy energy, invigorating middle warmer is let out, and has fall, oppose each other and yet also complement each other in dissipating, and is mutually made as using.With
Rhizoma Chuanxiong, Radix Saposhnikoviae, Fructus Ligustri Lucidi, Cortex Eucommiae phase 5 are ministerial drug altogether.
Ramulus Uncariae Cum Uncis：Gan Liang, Return liver, heart channel, The flat liver of heat-clearing, relieving spasm by subduing liver-wind,《Compendium of Materia Medica》Carry it and can control " big number of people rotation mesh
Dizzy, suppressing liver-wind ", and Yun Qiwei " handss, sufficient cloudy medicine of fainting.Foot is fainted cloudy main air, the main fire of Hand Jueyin, shy dizzy fortune, all liver-wind mutually fire
Disease, Ramulus Uncariae Cum Uncis leads to pericardium in edema with the liver involved, and the quiet fire of wind puts out, then all diseases are removed certainly.”《Collected statements on the herbal foundation》Claim its " dispelling wind evil and not dry, in and
Product ",《Bencao Congxin》Then call its " going wind very fast, to have wind disease person must preferably use it "；Deficiency of kidney-YIN, yin deficiency hyperactivity of fire, it is equipped with river again
Radix Achyranthis Bidentatae, sweetness and bitterness acid is flat, function invigorating the liver and kidney, bone and muscle strengthening, scattered blood stasis,《Do not record》Yan Qizhuan " fills out bone marrow, except pain in brain, benefit essence ",《Medicine
Property opinion》Call its " kidney tonifying, essence replenishing ",《Bencao Jingshu》Carry its can " high invigorating the liver and kidney, then hemapodium and essence is full ",《Book on Chinese herbal medicine justice》Cloud its " dredge
Sharp drop-down ", " under Radix Cyathulae, behavior is suitable for pain person in brain, the rising of many YANG pathogen, then gas fire is certainly latent." Zhang Jingyue calls it and " can walk 12
Meridians ", both can strengthen the power of monarch drug the kidney invigorating, and the meridians that can pass through, and ignite descending, with pungent scattered medicine compatibility, have fall, more favorably in liter
Liter in expelling wind drug dissipates and thoroughly sends out；Compatibility Hirudo, salty in the mouth, hardship, mild-natured, enter Liver Channel, the special removing blood stasis of work(, eliminating blood stasis and inducing menstruation.《Book on Chinese herbal medicine》Cloud：Main
By stagnant blood, Zhong Jing Didang Tang with Hirudo, salty bitter to let out blood-retention, Hirudo eating human blood, and property is slow is apt to into slow then hemopoietic is not
Wound, is apt to into then hard long-pending fragile, by means of its power to attack accumulate in the course of time stagnant, from favourable and harmless.Above three medicines make for assistant altogether.
The all medicine compatibilities in side, the kidney invigorating, wind-dispelling, promoting blood circulation entirely, three methods develop simultaneously, giving consideration to both the incidental and fundamental, mend eliminating stagnation and close, have benefit, in liter in leading to
Have fall, play altogether tonify Qi of the kidney, the work(of dispelling wind and network.
In order to preferably, by popularization and application of the present invention, on the basis of traditional Chinese medicine theory, the present invention is more concerned with the modern times
Study of pharmacy.With modern advanced research meanses, make great efforts to illustrate model of action and the mechanism of medicine, open further for invention
Send out using laying the first stone.
Chinese medicine preparation Pharmacodynamic test of active extract of the present invention is as follows：
(1), the hypotensive effect to spontaneous hypertensive rat
1st, material
Animal：Spontaneous hypertensive rat (SHR) 60, all males, 12 week old, body weight 250～300g.
Instrument：Big rat-tail pressure analyzer (BP-6 type).
Medicine：The present invention sends out the Chinese medicine stated.
Positive control：ENALAPRIL MALEATE TABLETS.
Administering mode：Gavage.
2nd, method
Body weight and the blood pressure of SHR, its body weight and the no obvious diversity of basic blood pressure is first measured before packet, therefore by 60
SHR is randomly divided into 5 groups, every group 12, gastric infusion.When administration time is every morning 8, during experiment, each group is all raised with SHR
Special feed, and free water.Measure weekly a body weight in experimentation, adjust dosage, experimental period according to body weight
For 8 weeks.
High dose group：Gavage by 15g/kg respectively daily；
Middle dose group：Gavage by 10g/kg respectively daily；
Low dose group：Gavage by 5g/kg respectively daily；
Positive controls, are gavaged by 0.278mg/ml daily.
3rd, observation index
(1), overview：Including feed, the water yield, body weight, outward appearance hair color, active situation etc..
(2), measure pressure value：Measure rat tail artery systolic pressure using BP-6 type measuring cell, survey one within two weeks during administration
Secondary blood pressure, surveys 3 values every time, takes the mean.Carry out within 1.5 hours after time of measuring is all selected in morning perfusion.The results are shown in Table 1.
The impact of the blood pressure to SHR for table 1 Chinese medicine of the present invention
| Group | 4 weeks | 8 weeks |
| Blank control group | -6.25±2.82 | -7.50±1.41 |
| High dose group | 14.88±4.61 | 34.5±3.96 |
| Middle dose group | 9.5±3.25 | 19.13±4.58 |
| Low dose group | 0.13±2.75 | 10.63±3.25 |
| Enalapril group | 28.75±8.35 | 33.13±6.24 |
Note：Compare with blank control group, P<0.05,
Result shows, after being administered 4 weeks, compared with blank group, medicine group and positive controls all can reduce spontaneous height
The blood pressure of blood pressure rats, is compared with blank control group, medicine high dose group, middle dose group, enalapril group P<0.01, medicine is low
Dosage group P<0.05, there is significant difference；Compared with enalapril group, the equal P of medicine high dose group, middle dose group, low dose group<
0.01 has significant difference.After being administered 8 weeks, compared with blank group, medicine group and positive controls all can reduce spontaneous height
The blood pressure of blood pressure rats, is compared with blank control group, medicine high dose group, middle dose group, low dose group, enalapril group P<
0.01, there is significant difference；Compared with enalapril group, the equal P of middle dose group, low dose group<0.01, there are significant difference, medicine
The hypotensive effect of thing high dose group is slightly better than enalapril group, but no difference of science of statistics.The feed of each group SHR, the water yield, body weight,
The zero differences such as outward appearance hair color, active situation.Test result indicate that, it is big that Chinese medicine of the present invention can significantly reduce spontaneous hypertension
The blood pressure of Mus.
(2), the impact to the hypotensive effect of aged patients with hypertension, fluctuation of blood pressure and pulse pressure difference
1st, data and method
Choose in March, -2016 in March, 2014 Shandong Traditional Chinese Medicine University's the first clinical hospitals and adopt Randomized double-blind parallel control
Multi-center clinical trial evaluates effectiveness and the safety that senile hypertension treated by this medicine.
(1), case is selected in step
Clinical trial is divided into three phases：
1. the introduction period：Previously in 4 weeks rule Oral glucose tolerance test plan those selected, disable whole resisting hypertension 5
Above half-life (generally 1 week), is checked comprehensively, including inquiry medical history, physical examination, tranquillization 12 Lead Synchronous ECG
With 24 hr Ambulatory EKG Monitoring, ultrasoundcardiogram, hepatic and renal function, the inspection of hematuria stool routine etc., investigate thoroughly the cause of disease as far as possible.
2. the eluting phase：The blind oral placebo granule of introduction period eligible list 1 week.It is selected in and do not take within first 4 weeks any anti-high blood
The patient of pressure chemical drugss or Chinese medicine can be directly entered the eluting phase.
3. the eluting phase eligible check brachial arterial pressure person that still conforms to inclusive criteria, double blind random is pressed sequence number and is entered test.
The present invention chooses 400 senile hypertension cases, random A group 100 people, B group 100 people, C group 100 people, D group 100
People.This test is on the basis of clinic in the past and pharmacology evidence, basic in internationally recognized standardization antihypertensive therapy scheme
On carry out pai n nursing.In view of there is no special for treating treatment of older patient with isolated systolic (ISH) at present, reducing the anti-height of pulse pressure difference
Blood pressure medication, based on generally acknowledged effective, similar comparable principle, using placebo plus standardization antihypertensive therapy scheme as A
Group (blank control group)；The kidney invigorating and network side (one) share standardization antihypertensive therapy scheme and intervene as B group, the kidney invigorating and network side
(2) share standardization antihypertensive therapy scheme to intervene as C group, Chinese medicine of the present invention shares standardization resisting hypertension and controls
Treatment scheme is intervened as D group.
(2), therapeutic scheme
A group (blank control group) gives resisting hypertension western medicine：Amlodipine Besylate Tablets 5mg, often early 1 time, Wen Kai
Water delivery service, after 2 weeks, reach mark blood pressure person continues to take and terminates to experiment.If after 2 weeks, blood pressure is not up to standard plus uses Irbesartan Tablets
150mg, often early 1 time, plus with latter 2 weeks blood pressures still not up to standard then again plus use hydrochlorothiazide tablet 12.5mg, often early 1 time, extremely test and tie
Bundle.
B group (the kidney invigorating and one group of network side), on the basis of taking A group medicine, gives the kidney invigorating and network side (one) decoction (Radix Rehmanniae Preparata
Huang, Herba Taxilli, Radix Astragali, Rhizoma Polygonati, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Radix Clematidis, Ramulus Uncariae macrophyllae, Rhizoma Chuanxiong, Radix Saposhnikoviae) decoction is big by Shandong Chinese medicine
Learn the first clinical hospitals Chinese medicine preparation section and offer is provided.2 times a day, each 30ml, sooner or later takes within 1 hour after meal.
C group (the kidney invigorating and two groups of network side), on the basis of taking A group medicine, gives the kidney invigorating and network side (two) decoction (fries Du
Secondary, Herba Taxilli, Fructus Ligustri Lucidi, Radix Astragali, Herba Epimedii, Rhizoma Polygonati, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Hirudo, Bombyx Batryticatus, Rhizoma Gastrodiae) soup
Agent, being made by the first clinical hospitals Chinese medicine preparation section of Shandong Traditional Chinese Medicine University provides.2 times a day, each 30ml, and sooner or later after meal 1
Hour is taken.
D group (of the present invention group), on the basis of taking A group medicine, gives Chinese medicine granules of the present invention, by Shandong
Medical pharmaceutical university the first clinical hospitals Chinese medicine preparation section makes to be provided.2 times a day, 1 bag every time, sooner or later takes within 1 hour after meal.
All equal continuous uses of patient 6 months.All other drugs are disabled during treatment.
(3), observation index
1. safety indexes
Including symptom, sign, untoward reaction and laboratory examination results.Evaluation methodology using descriptive analysis.Bad
The dependency of event and by reagent is judged with 5 grades, that is, " certainly irrelevant ", " can not affirm ", " possibility is relevant ", " be likely to have
Pass ", " certainly relevant ", by " may be relevant ", " being likely to relevant ", " certainly relevant ", three includes adverse reaction rate system
Meter.
2. health giving quality index
Follow-up is all carried out before patient's medication every time, in 7:30～8:00, in ABPM Room dress ABPM monitoring, carries out 24
Hour ABPM monitors, and no longer takes medicine during mensure.
Clinical blood pressure detects (CBPM)：In treatment the 4th, 8 weeks and 3rd month, 6 the end of month each follow-up 1 time.
Ambulatory blood pressure monitoring (ABPM)：It is all that those selected starts in eluting end of term treatment phase, the 6th the end of month for the treatment of phase divides
Do not carry out ABPM detection in 24 hours.Blood pleural effusion is higher than normal number of times percentage rate for blood pressure, with blood pleural effusion>30% work
One of index raising for diagnosis blood pressure.
Ultrasoundcardiogram：After measurement Causal blood pressure, all persons under inspection all rest 15～20 minutes, to ensure ultrasoundcardiogram
It is tranquility, left ventricular interior diameter diastasiss (LVDd) of 3～5 cardiac cycles of METHOD FOR CONTINUOUS DETERMINATION, interventricular septal thickness during detection
(IVST), Left ventricular posterior wall thickness (LVPWT), left ventricular mass (LVM), calculates the often amount of fighting (SV), cardiac output (C0) and left room
Ejection fraction (LVEF).
(4), efficacy of antihypertensive treatment evaluation criteria
1. curative effect of disease evaluation criteria
Treatment is effectively：Shrink drops>10mmHg；
Target control treatment：Systolic pressure<140mmHg.
2. Safety Evaluation Index
Safety evaluation standard：
1 grade：Safety, no any untoward reaction.
2 grades：Relatively safety, if any untoward reaction, is not required to process and can continue to be administered.
3 grades：There is safety problem, moderate untoward reaction, can continue after process to be administered.
4 grades：Because of untoward reaction termination test.
2nd, result
(1), Treatment of Hypertension
After 6 months standardization joint antihypertensive drug therapies, the blood pressure of four groups of patients is all effectively controlled, blood pressure level
All steadily decline.24h that four groups of ABPM measure, all significantly reduce with night mean pressure, SBP and DBP in the daytime, CBPM and ABPM
The PP measuring significantly reduces before all relatively treating, and blood pressure night rate of descent significantly increases, and blood circadian is improved.
Compared with blank group, CPP reduces amplitude significance (P to B group<0.05) 24h DBP, SBP-L's that, ABPM measures
24h and night mensure, 24h PP, nighttime SBP rate of descent there were significant differences (P<0.05), 24h PP there were significant differences (P<
0.01)、
C group compared with blank group, 24h DBP Amplitude of Hypotensive that ABPM measures, 24h MAP there were significant differences (P<0.05)；
Compared with blank group, the 24h SBP of SBP, CPP, ABPM mensure, in the daytime DBP, 24h PP, 24h MAP all have D group
Significant difference (P<0.01), the 24h SBP that DBP, ABPM measure, 24h DBP, night DBP all there were significant differences (P<0.05),
Prompting D group has good hypotensive effect, and while reducing systolic pressure, diastolic pressure change is little, thus pulse pressure difference reduces
Significantly, this point has obvious advantage compared with other three groups.
Refer to table 2.
Causal blood pressure, the change of ambulatory blood pressure before and after 2 four groups of treatments of table
Note：SeSBP：Even survey sitting systolic blood pressure；
SeDBP：Even survey SiDBP；
CPP：Even survey pulse pressure；
24h：Whole day meansigma methodss；
d：In the daytime meansigma methodss；
n：Night meansigma methodss；
L：Blood pressure load；
MAP：Mean arterial pressure；
Compare with before treatment：*P<0.05, * * P<0.01；
Compare with matched group：△P<0.05, ▲ P<0.01.
(2), echocardiographic parameters
Myocardial Mass Measured before four groups of treatments, left room shrink and diastolic function has comparability (P>0.5).After four groups of treatments
Left ventricular hypertrophy index all reduces (P<0.01), but compared with blank group, the LVDd of D group declines substantially (P<0.05), and myocardium
Weight minimizing becomes apparent from, and diastolic function improves more notable (P<0.01).Refer to table 3.
The comparison of myocardial Mass Measured and left heart function before and after 3 four groups of treatments of table
Note：* compare with before treatment, P<0.01；△ is compared with blank group, P<0.05；▲ compare with blank group, P<0.01.
(3), safety evaluatio
During treatment, A group has 2 cardiocerebrovasculaevents events to occur, and B, C group respectively has 1 cardiocerebrovasculaevents events to occur.Medication 4 weeks
Afterwards to off-test, A group has 82 people (85.4%) and needs two kinds of antihypertensive drug use in conjunction, is wherein unable to tolerance dose and adjusts
Whole person 10；B group has 55 people (60.0%) and needs two kinds of antihypertensive drug use in conjunction, is wherein unable to tolerance dose adjustment person
6；C group has 54 people (58.7%) and needs two kinds of antihypertensive drug use in conjunction, is wherein unable to tolerance dose adjustment person 2；D
Group has 45 people (45.9%) and needs two kinds of antihypertensive drug use in conjunction, adjusts case without being unable to tolerance dose.Connection
Share the comparison of medicine rate, group difference has significance (P<0.01).
A group 3, B group 5, C group 6, D group 4 feel nervous, continuation symptom after taking medicine alleviation when starting medicinal.B group 7
, nausea, vomiting, abdominal distention, stomachache, diarrhoea, have led to not in example, 7 appearance more serious gastrointestinal irritations of ratio of C group
Become test, backed off after random case.Slight gastrointestinal reaction in D group, no exits case.
The present invention compared with prior art, has the advantages that：
For the kidney qi virtual loss of hyperpietic's generally existing, blood vessels from the pathogenesis of disease, Chinese medicine of the present invention is existed
Clinically it is used for treating hypertension, with the kidney invigorating gas and blood vessels for main method for the treatment of, embody dual regulation, systolic pressure and diastole
Pressure is all drawn close to normal level, and systolic pressure reduces, diastolic pressure change is less or even constant or raises, pulse pressure reduces, and achieves good
Good clinical efficacy.The present invention can improve hyperpietic's dizziness headache, Hiccough and deaf, hypomnesis, asthenia is drowsiness, neither
Cold-resistant and thermo-labile, the loss of hairs that turns white, luxated tooth are early de-, soreness of the waist and knees, frequent micturition, frequent urination at night, purplish tongue or have petechia ecchymosis
Etc. symptom, especially suitable aged patients with hypertension, have no toxic side effect, simple production process, product quality is easy to control.
Specific embodiment
With reference to embodiment, the present invention is further illustrated, but it is not intended to limit the enforcement of the present invention.
Embodiment 1
Weigh 30 parts of the Radix Astragali, 30 parts of Rhizoma Polygonati, 30 parts of parasitism, 30 parts of Fructus Ligustri Lucidi, 10 parts of Radix Cyathulae, Rhizoma Alismatis by ratio of weight and the number of copies
30 parts, 30 parts of the Cortex Eucommiae, 8 parts of Rhizoma Chuanxiong, 8 parts of Radix Saposhnikoviae, 6 parts of Hirudo, the mixing of 8 parts of Ramulus Uncariae Cum Uncis, add 10 times of water, decoct 2 hours, filter,
Medicinal residues continue to be boiled 1 hour with 8 times of decoctings, filter, merging filtrate, and concentrating the filtrate to relative density is 1.08-1.15g/cm3,
Weigh 10 parts of dextrin, at a temperature of 80 ± 20 DEG C, dextrin is added extractum mix homogeneously, then dry at a temperature of 100 ± 40 DEG C
Dry, pelletize, obtain final product the Chinese medicine for the treatment of senile hypertension.
Embodiment 2
Weigh 16 parts of the Radix Astragali, 5 parts of Rhizoma Polygonati, 5 parts of parasitism, 10 parts of Fructus Ligustri Lucidi, 5 parts of Radix Cyathulae, Rhizoma Alismatis 4 by ratio of weight and the number of copies
Part, 5 parts of the Cortex Eucommiae, 3 parts of Rhizoma Chuanxiong, 5.4 parts of Radix Saposhnikoviae, 3.2 parts of Hirudo, 5.4 parts of Ramulus Uncariae Cum Uncis, wherein Fructus Ligustri Lucidi, the Cortex Eucommiae, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis uses 8
60% ethanol extraction twice, 1 hour every time, filters, crosses liquid standby again；Remaining seven flavor medicine material, adds 8 times of water, decocts 2 hours,
Filter, medicinal residues continue to be boiled 1 hour with 6 times of decoctings, filter, merging filtrate, concentrating the filtrate to relative density is 1.08-1.15g/
cm3, add 2 times amount ethanol to make precipitation, filtration, filtrate is merged with ethanol extract, reclaims ethanol, mixes, adds water to 1000ml,
Standing, filtration, fill, obtain final product the Chinese medicine for the treatment of senile hypertension.
Embodiment 3
Weigh by ratio of weight and the number of copies 8 parts of the Radix Astragali, 4 parts of Rhizoma Polygonati, parasitic 4 parts, 4 parts of Fructus Ligustri Lucidi, 3 parts of Radix Cyathulae, 8 parts of Rhizoma Alismatis,
4 parts of the Cortex Eucommiae, 2.7 parts of Rhizoma Chuanxiong, 2.7 parts of Radix Saposhnikoviae, 1.6 parts of Hirudo, 2.7 parts of Ramulus Uncariae Cum Uncis, mixing, plus 6 times amount decoctings boil 1 hour, filtration,
Medicinal residues continue to be boiled 1 hour with 4 times amount decoctings, filtration, merging filtrate, and it is 1.10-1.25g/cm that filtrate is concentrated into relative density3,
Add starch, Magnesium Stearate proper quantity, mix, pelletize, be dried, be pressed into 1000, film coating, obtain final product treatment senile hypertension
Chinese medicine.
Embodiment 4
Weigh 12 parts of the Radix Astragali, 10 parts of Rhizoma Polygonati, 10 parts of parasitism, 4 parts of Fructus Ligustri Lucidi, 10 parts of Radix Cyathulae, Rhizoma Alismatis 8 by ratio of weight and the number of copies
Part, 10 parts of the Cortex Eucommiae, 6 parts of Rhizoma Chuanxiong, 5.4 parts of Radix Saposhnikoviae, 3.2 parts of Hirudo, 5.4 parts of mixing of Ramulus Uncariae Cum Uncis, add 10 times of water, decoct 2 hours, mistake
Filter, medicinal residues continue to be boiled 1 hour with 8 times of decoctings, filter, merging filtrate, and being concentrated into relative density is 1.20～1.24, using spraying
Pelletize, fill capsule, obtain final product the Chinese medicine for the treatment of senile hypertension.
Embodiment 5
Weigh by ratio of weight and the number of copies 8 parts of the Radix Astragali, 4 parts of Rhizoma Polygonati, parasitic 4 parts, 4 parts of Fructus Ligustri Lucidi, 3 parts of Radix Cyathulae, 10 parts of Rhizoma Alismatis,
4 parts of the Cortex Eucommiae, 2 parts of Rhizoma Chuanxiong, 2 parts of Radix Saposhnikoviae, 1 part of Hirudo, 2 parts of Ramulus Uncariae Cum Uncis, mixing, plus 6 times amount decoctings boil 1 hour, filtration, and medicinal residues continue
Boiled 1 hour with 4 times amount decoctings, filtration, merging filtrate, it is 1.10-1.25g/cm that filtrate is concentrated into relative density3, addition starch,
Magnesium Stearate proper quantity, mixes, and pelletizes, and is dried, is pressed into 1000, and film coating obtains final product the Chinese medicine for the treatment of senile hypertension.
Claims (5)
1. a kind of Chinese medicine treating senile hypertension is it is characterised in that include the raw material of following parts by weight：Radix Astragali 8-30 part, Huang
Smart 4-30 part, parasitic 4-30 part, Fructus Ligustri Lucidi 4-30 part, Radix Cyathulae 3-10 part, Rhizoma Alismatis 4-30 part, Cortex Eucommiae 4-30 part, Rhizoma Chuanxiong 2-8
Part, Radix Saposhnikoviae 2-8 part, Hirudo 1-6 part, Ramulus Uncariae Cum Uncis 2-8 part.
2. the Chinese medicine for the treatment of senile hypertension according to claim 1 is it is characterised in that include the former of following parts by weight
Material：8 parts of the Radix Astragali, 4 parts of Rhizoma Polygonati, 4 parts of parasitism, 4 parts of Fructus Ligustri Lucidi, 3 parts of Radix Cyathulae, 8 parts of Rhizoma Alismatis, 4 parts of the Cortex Eucommiae, 2.7 parts of Rhizoma Chuanxiong, Radix Saposhnikoviae
2.7 parts, 1.6 parts of Hirudo, 2.7 parts of Ramulus Uncariae Cum Uncis.
3. the Chinese medicine for the treatment of senile hypertension according to claim 1 is it is characterised in that include the former of following parts by weight
Material：16 parts of the Radix Astragali, 5 parts of Rhizoma Polygonati, 5 parts of parasitism, 10 parts of Fructus Ligustri Lucidi, 5 parts of Radix Cyathulae, 4 parts of Rhizoma Alismatis, 5 parts of the Cortex Eucommiae, 3 parts of Rhizoma Chuanxiong, Radix Saposhnikoviae
5.4 parts, 3.2 parts of Hirudo, 5.4 parts of Ramulus Uncariae Cum Uncis.
4. the Chinese medicine for the treatment of senile hypertension according to claim 1 is it is characterised in that include the former of following parts by weight
Material：12 parts of the Radix Astragali, 10 parts of Rhizoma Polygonati, parasitic 10 parts, 4 parts of Fructus Ligustri Lucidi, 10 parts of Radix Cyathulae, 8 parts of Rhizoma Alismatis, 10 parts of the Cortex Eucommiae, 6 parts of Rhizoma Chuanxiong,
5.4 parts of Radix Saposhnikoviae, 3.2 parts of Hirudo, 5.4 parts of Ramulus Uncariae Cum Uncis.
5. according to claim 1 treatment senile hypertension Chinese medicine it is characterised in that：The dosage form of described Chinese medicine is oral
Liquid, tablet, capsule or granule.
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