CN104398795A - Traditional Chinese medicine composition for controlling hypertension and protecting hypertension target organ against damage and application thereof - Google Patents
Traditional Chinese medicine composition for controlling hypertension and protecting hypertension target organ against damage and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for controlling hypertension and protecting hypertension target organ against damage, and the traditional Chinese medicine composition is prepared from the following raw material medicines: rhizoma chuanxiong, bupleurum, coptis root, notopterygium, radix saposhnikoviae, prunella spike, cyathula root, polygonatum, concha haliotidis, fried radix scutellariae and herba taxilli. The invention also provides the application of the traditional Chinese medicine composition. The advantages of the traditional Chinese medicine composition are that: the traditional Chinese medicine composition can significantly improve blood pressure indexes of pre hypertension patients, significantly reduces systolic pressure and diastolic pressure level of spontaneously hypertensive rats (SHR), and more important, has significant protective effect against target organ damage in heart, brain and kidney. The traditional Chinese medicine composition used in hypertension early intervention can not only delay the process of hypertension, more important, has the protective effect against target organ damage in hypertension, can be clinically and widely popularized, delays target organ damage, and improves the life quality of the patients.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, specifically, is a kind of Chinese medicine composition and application thereof of preventing and treating hypertension, protecting target organs of patients with essential hypertension infringement.
Background technology
Hypertension (hy
pertension) refer to that under quiescent condition, systolic pressure and/or diastolic pressure increase (>=140mmHg/90mmHg), often with target organ function or organic changes such as lipid metabolic disorder and the heart, brain, kidney and retinas.Systolic pressure between 120 ~ 139mmHg and/or diastolic pressure be prehypertensive or normal high level between 80 ~ 89mmHg.
Hypertension is modal cardiovascular diseases, is the great public health problem in global range.Epidemiological study shows, and China 18 years old and above prevalence of hypertension rate are 18.8%, estimate that national number of patients is more than 1.6 hundred million.China's hypertension prevention and control guide (revised edition in 2010) is pointed out: annual China will increase hyperpietic 1,000 ten thousand newly, just have 1 to suffer from hypertension in every 5 adults, and cri dernier cri disease is learned in about every 3 adults of the investigation display U.S. just 1 hyperpietic.Prehypertensive is hypertension most important " hidden danger crowd ".The urban population of China about 59.31% is in the prehypertensive stage, the rural population of about 44.15% is prehypertensive, and research shows: blood pressure is at the middle-aged population of 120 ~ 129/80 ~ 84mmHg and 130 ~ 139/85 ~ 90mmHg, and changing hypertensive probability after 10 years into has 45% and 64% respectively.Epidemiological study shows, and compared with blood pressure normal person, the probability of prehypertensive generation apoplexy adds 1.66 times, and the probability that end stagerenaldisease occurs adds 1.59 times, and the incidence rate of cardiovascular disease adds 2.0 times.Therefore, early intervention, can effectively delay hypertensive process, the more important thing is the infringement delaying target organ, improve the quality of life of patient.
Rhizoma Chuanxiong (Chuanxiong) is the rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel.There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.Can be used for stagnation of QI and blood pain card, headache, rheumatic arthralgia etc.
Radix Bupleuri (Chaihu) is umbelliferae bupleurum Bu
pleurum chinensis DC. or Radix Bupeuri Scorzonerfolii. Bu
pthe dry root of leurum scorzonerifolium Willd..Bitter in the mouth, pungent, cold nature.Return liver, gallbladder meridian.Having induces sweat brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of elevate a turnable ladder yang-energy.Can be used for exterior syndrome heating and shaoyang disease, stagnation of QI due to depression of the liver, collapse of QI, internal organs prolapsus etc.
Rhizoma Coptidis (Huanglian) is ranunculaceae plant Rhizoma Coptidis Co
pthe dry rhizome of tis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao C. deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall C. teeta Wall..Bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, gallbladder, large intestine channel.There is heat clearing and damp drying, effect of eliminating fire and detoxication.Can be used for damp and hot feeling of fullness, vomiting acid regurgitation, damp-heat dysentery, unconsciousness due to high fever, dysphoria and insomnia, heat in blood tells nosebleed, carbuncle furuncle, and conjunctival congestion is had a toothache, and quench one's thirst, external treatment eczema, eczema, auditory meatus are suppurated.
Rhizoma Et Radix Notopterygii (Qianghuo) is samphire Rhizoma Et Radix Notopterygii Noto
pterygium incisum Tncisum Ting ex H.Chang or Radix et Rhizoma Notopterygii Noto
pthe dry rhizome of terygium forbesii Boiss. and root.Acrid in the mouth, hardship, warm in nature, return bladder, kidney channel.There is the cold expelling that induces sweat, expelling wind and dampness, effect of pain relieving.Can be used for anemofrigid cold, anemofrigid-damp arthralgia etc.
Radix Saposhnikoviae (Fangfeng) is umbelliferae Saposhnikovia divaricata Sa
pthe root of oshnikovia divaricata (Turez.) Schischk..Acrid in the mouth, sweet, slightly warm in nature, returns bladder, liver, spleen channel.There is expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.Can be used for diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, can be used in addition putting out endogenous wind with relieving convulsion, also can be used for insufficiency of the spleen leading to overabundance of dampness, having loose bowels caused by clear YANG failing to ascend.
Spica Prunellae (Xiakucao) is labiate Spica Prunellae
pthe dry fruit ear of runella vulgaris L..Acrid in the mouth, hardship, cold in nature, return liver, gallbladder meridian.There is clearing away heat-fire, improving eyesight, effect of mass dissipating and swelling eliminating.Can be used for conjunctival congestion and swelling pain, dizzy, order pearl nyctalgia of having a headache, scrofula, goiter, acute mastitis swells and ache.
Radix Cyathulae (Chuanniuxi) is the root of Radix Cyathulae (RADIX CYATHULAE) Cyathula officinalis Kuan.Bitter in the mouth, sweet, sour, property is put down, and returns liver, kidney channel.There is promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, effect that ignite (blood) is descending.Can be used for the amenorrhea of stagnation of blood stasis, dysmenorrhea, abdominal pain during menstruation, retention of placenta and fall flutterring the pain of injury, soreness of waist and knee joint, flaccidity and weakness of the lower limbs, stranguria, edema, dysuria, burning hot scorching, the headache of hyperactivity of fire caused by deficiency of YIN, dizzy, toothache, aphtha of the mouth and tongue, haematemesis, epistaxis etc.
Rhizoma Polygonati (Huangjing) is liliaceous plant Rhizoma Polygonati
polygonatum sibiricum Red., P. kingianum
p.kingianum Coll.et Hemsl. or Polygonatum cyrtonema Hua
p.cyrtonema the rhizome of Hua.Sweet in the mouth, property is put down, and returns spleen, lung, kidney channel.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, effect of kidney tonifying.Can be used for lung-dryness syndrome due to deficiency of YIN, the phthisical cough chronic cough of the few expectorant of dry cough and YIN-deficiency of the lung and kidney, insufficiency of the spleen the moon wound card, deficiency of kidney-essence etc.
Concha Haliotidis (Shijueming) is Bao Ke animal Haliotis diversicolor (light bedstone Semen Cassiae) Haliotis diversicolor Reeve, haliotis discus hannai Ino (hair bedstone Semen Cassiae) Haliotis discus hannai Ino, sheep Bao Haliotis ovina Gmelin, haliotis ruber Haliotis ruber (Leach), ear Bao Haliotis asinina Linnaeus or white Bao Haliotis laevigata (Donovan) shell.Salty in the mouth, cold in nature, return Liver Channel.There is suppressing the hyperactive liver and subsiding YANG, effect of liver heat removing and eyesight improving.Can be used for excessive rising of liver-YANG, have a dizzy spell, conjunctival congestion, cataracta, blurring of vision etc.
Radix Scutellariae (Huangqin) is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Bitter in the mouth, cold in nature, return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.Can be used for hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, jaundice dysentery, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement etc.
Herba Taxilli (Sangjisheng) is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Bitter in the mouth, sweet, property is put down, and returns liver, kidney channel.There is Eradicates rheumatism, invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.Can be used for rheumatism arthromyodynia, metrorrhagia through many, blood leaking in gestation, frequent fetal movement, in addition, still can blood pressure lowering, can be used for hypertension etc.
But about the Chinese medicine composition and the application thereof that prevent and treat hypertension, protect target organs of patients with essential hypertension infringement of the present invention, yet there are no report.
Summary of the invention
The object of the invention is for deficiency of the prior art, a kind of Chinese medicine composition preventing and treating hypertension, the infringement of protection target organs of patients with essential hypertension is provided.
Of the present invention again one object be that a kind of application of Chinese medicine composition preventing and treating hypertension, the infringement of protection target organs of patients with essential hypertension is provided.
For achieving the above object; the technical scheme that the present invention takes is: a kind of Chinese medicine composition preventing and treating hypertension, the infringement of protection target organs of patients with essential hypertension, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 10-20 part, Radix Bupleuri 10-20 part, Rhizoma Coptidis 3-9 part, Rhizoma Et Radix Notopterygii 10-20 part, Radix Saposhnikoviae 10-20 part, Spica Prunellae 20-40 part, Radix Cyathulae 10-20 part, Rhizoma Polygonati 10-20 part, Concha Haliotidis 15-25 part, Radix Scutellariae (parched) 10-20 part, Herba Taxilli 10-20 part.
Described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 13-17 part, Radix Bupleuri 13-17 part, Rhizoma Coptidis 5-7 part, Rhizoma Et Radix Notopterygii 13-17 part, Radix Saposhnikoviae 13-17 part, Spica Prunellae 27-33 part, Radix Cyathulae 13-17 part, Rhizoma Polygonati 13-17 part, Concha Haliotidis 17-23 part, Radix Scutellariae (parched) 13-17 part, Herba Taxilli 13-17 part.
Described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Rhizoma Coptidis 6 parts, Rhizoma Et Radix Notopterygii 15 parts, Radix Saposhnikoviae 15 parts, Spica Prunellae 30 parts, Radix Cyathulae 15 parts, Rhizoma Polygonati 15 parts, Concha Haliotidis 20 parts, Radix Scutellariae (parched) 15 parts, Herba Taxilli 15 parts.
For realizing above-mentioned second object, the technical scheme that the present invention takes is: the application of described Chinese medicine composition in the medicine of preparation prophylaxis of hypertension.
The application of described Chinese medicine composition in the medicine of preparation protection target organs of patients with essential hypertension infringement.
The invention has the advantages that:
Chinese medicine composition of the present invention (liver heat removing kidney tonifying dispel the wind Chinese medicine compound) significantly reduce prehypertensive patient systolic pressure, diastolic pressure level and 24h, daytime, night average systolic, diastolic pressure level, and significantly reduce prehypertensive patient 24h, daytime, night systolic pressure load.This result provides brand-new means of prevention for hypertensive early intervention.Meanwhile, the present invention adopts male spontaneous hypertensive rat (SHR) as hypertension model, and research and inquirement liver heat removing kidney tonifying dispels the wind the control of Chinese medicine compound to SHR rat blood pressure and the protective effect to target organ thereof.Result of study shows: liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind significantly reduces SHR rat systolic pressure, diastolic pressure level, the more important thing is to have significant protective effect to the heart, brain, kidney target organ damage.Liver heat removing kidney tonifying Chinese medicine compound early intervention hypertension of dispeling the wind not only delays hypertensive process; the more important thing is the protective effect to target organs of patients with essential hypertension infringement; brand-new treatment means is provided for hypertensive early prevention and treatment and to the protective effect of target organs of patients with essential hypertension infringement; effectively can instruct clinical application; delay the infringement of target organ, improve the quality of life of patient.
Accompanying drawing explanation
Chinese medicine compound of dispeling the wind accompanying drawing 1,2. liver heat removing kidney tonifying significantly reduces SHR rat systolic pressure, diastolic pressure level: 4 week age, SHR male rat was as hypertension animal model, regular diet, after adaptability raises one week, be divided into model group, Chinese drug-treated group, positive controls (amlodipine group, Candesartan group) at random.With with week age WKY male rat for Normal group.When the 6th week age, gave pharmaceutical intervention respectively, intervene 14 weeks altogether.Tail platen press is adopted weekly to measure rat systolic pressure, diastolic pressure.As shown in accompanying drawing 1,2, compared with Normal group, model group SHR rat systolic pressure, diastolic pressure continue to raise with changing blood pressure age in week; Compared with model group, Chinese drug-treated group significantly reduce SHR rat systolic pressure, diastolic pressure (
p<0.05).
Accompanying drawing 3,4. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind is remarkable to the protective effect of SHR rat heart: all laboratory animals, when 20 week age, put to death animal, cores dirtyly to carry out pathological observation.Main employing paraffin section, Hematoxylin-eosin dyes, the change of basis of microscopic observation pathomorphism.Masson trichrome stain observes fibrosis.As shown in Figure 3, compared with Normal group, the visible myocardium multiple focal necrosis of model group, massive inflammatory cells infiltrated, congestion and edema between muscle fiber; Compared with model group, Chinese drug-treated group significantly reduce cardiac muscular tissue's focal necrosis (
p<0.05), and be significantly better than amlodipine group (
p<0.05).In accompanying drawing 3b, compare with model group, *
p<0.05, compared with amlodipine group, ▲
p<0.05.As shown in Figure 4, compared with Normal group, model group myocardial vascular surrounding annulusization significantly increases; Compared with model group, Chinese drug-treated group significantly reduce myocardial vascular surrounding annulus area (
p<0.05).In accompanying drawing 4b, compare with normal group, #
p<0.05; Compare with model group, *
p<0.05.
Accompanying drawing 5,6. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind is remarkable to the protective effect of SHR rat kidney: during 20 week age, puts to death animal, gets kidney and carry out pathological observation.Main employing paraffin section, the dyeing of row Hematoxylin-eosin and Masson trichrome stain.As shown in Figure 5, compared with Normal group, model group SHR rat kidney organizes the infiltration (model group-1) of visible renal interstitial inflammatory cell, and mucous membrane of renal pelvis epithelial damage comes off (model group-2).Chinese drug-treated group significantly reduce SHR kidney of rats interstitial inflammatory cells infiltrate (
p<0.05).In accompanying drawing 5b, compare with model group, *
p<0.05, compared with amlodipine group, ▲
p<0.05.As shown in Figure 6, Chinese drug-treated group significantly reduces SHR renal interstitial fibrosis rat degree, and be significantly better than amlodipine group (
p<0.05).In accompanying drawing 6b, compare with model group, *
p<0.05, compared with amlodipine group, ▲
p<0.05.
Accompanying drawing 7. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind is remarkable to the protective effect of SHR rat cerebral tissue: during 20 week age, puts to death animal, gets cerebral tissue and carry out pathological observation.Main employing paraffin section, row Hematoxylin-eosin dyes.As shown in Figure 7, compared with Normal group, the visible intracranial hemorrhage of model group rats cerebral tissue (model group-1), meningovascular dilatation and congestion (model group-2).The rarely seen meningovascular dilatation and congestion of Chinese drug-treated group (CM), and lesion degree significantly lower than amlodipine group, Candesartan group (
p<0.05).In accompanying drawing 7b, compare with model group, *
p<0.05, compared with amlodipine group, ▲
p<0.05, compared with Candesartan group, ◆
p<0.05.
Detailed description of the invention
Below in conjunction with accompanying drawing, detailed description of the invention provided by the invention is elaborated.
Prevent and treat a Chinese medicine composition for hypertension, the infringement of protection target organs of patients with essential hypertension, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 10-20 part, Radix Bupleuri 10-20 part, Rhizoma Coptidis 3-9 part, Rhizoma Et Radix Notopterygii 10-20 part, Radix Saposhnikoviae 10-20 part, Spica Prunellae 20-40 part, Radix Cyathulae 10-20 part, Rhizoma Polygonati 10-20 part, Concha Haliotidis 15-25 part, Radix Scutellariae (parched) 10-20 part, Herba Taxilli 10-20 part.
embodiment 1 Chinese medicine composition
Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Rhizoma Coptidis 6 parts, Rhizoma Et Radix Notopterygii 15 parts, Radix Saposhnikoviae 15 parts, Spica Prunellae 30 parts, Radix Cyathulae 15 parts, Rhizoma Polygonati 15 parts, Concha Haliotidis 20 parts, Radix Scutellariae (parched) 15 parts, Herba Taxilli 15 parts.
embodiment 2 Chinese medicine composition
Rhizoma Chuanxiong 13 parts, Radix Bupleuri 17 parts, Rhizoma Coptidis 5 parts, Rhizoma Et Radix Notopterygii 13 parts, Radix Saposhnikoviae 17 parts, Spica Prunellae 27 parts, Radix Cyathulae 17 parts, Rhizoma Polygonati 13 parts, Concha Haliotidis 23 parts, Radix Scutellariae (parched) 13 parts, Herba Taxilli 17 parts.
embodiment 3 Chinese medicine composition
Rhizoma Chuanxiong 17 parts, Radix Bupleuri 13 parts, Rhizoma Coptidis 7 parts, Rhizoma Et Radix Notopterygii 17 parts, Radix Saposhnikoviae 13 parts, Spica Prunellae 33 parts, Radix Cyathulae 13 parts, Rhizoma Polygonati 17 parts, Concha Haliotidis 17 parts, Radix Scutellariae (parched) 17 parts, Herba Taxilli 13 parts.
embodiment 4 Chinese medicine composition
Rhizoma Chuanxiong 10 parts, Radix Bupleuri 20 parts, Rhizoma Coptidis 3 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Saposhnikoviae 10 parts, Spica Prunellae 20 parts, Radix Cyathulae 20 parts, Rhizoma Polygonati 10 parts, Concha Haliotidis 15 parts, Radix Scutellariae (parched) 20 parts, Herba Taxilli 10 parts.
embodiment 5 Chinese medicine composition
Rhizoma Chuanxiong 20 parts, Radix Bupleuri 10 parts, Rhizoma Coptidis 9 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Saposhnikoviae 20 parts, Spica Prunellae 40 parts, Radix Cyathulae 10 parts, Rhizoma Polygonati 20 parts, Concha Haliotidis 25 parts, Radix Scutellariae (parched) 10 parts, Herba Taxilli 20 parts.
the preparation of embodiment 6 Chinese medicine composition
The pharmaceutical dosage form that the arbitrary described Chinese medicine composition of embodiment 1-5 is prepared by conventional formulation means.
embodiment 7 clinical trial, animal experiment
In the present embodiment, based on the basis that early stage observes, collect Clinical Hypertension patient 20 in early stage example, give liver heat removing kidney tonifying method (Chinese medicine composition of embodiment 1) of dispeling the wind and intervene 1 course for the treatment of (6 months), respectively Clinical blood pressure, 24h ambulatory blood pressure are studied, and clear and definite liver heat removing kidney tonifying dispels the wind, Chinese medicine compound not only significantly reduces systolic pressure, diastolic pressure in discussion, and significantly reduces systolic pressure load.And; in the present embodiment; we adopt 4 week age SHR rat as hypertension animal model, and clear and definite liver heat removing kidney tonifying dispels the wind, Chinese medicine compound significantly can reduce SHR rat systolic pressure, diastolic pressure in research, and has significant protective effect to the caused by hypertension heart, brain, kidney target organ damage.This research disclose first liver heat removing kidney tonifying dispel the wind the significant hypotensive effect of Chinese medicine compound and to target organs of patients with essential hypertension infringement protective effect, for hypertensive control and to target organs of patients with essential hypertension infringement protective effect brand-new thinking is provided.
One, method
1. clinical research sample collection
For clinical sample of the present invention all from the court, and all object of study are all conscientiously read and are signed Informed Consent Form, meet ethical standard.Object of study is male, and the age is between 30-60 year.When not using antihypertensive drugs, non-three measurements on the same day, systolic pressure 120 ~ 139mmHg and/or diastolic pressure are prehypertensive at 80 ~ 89mmHg.All object of study previously without other cardiovascular disease, serious hepatic and renal function injure, diabetes, the infectious disease such as hepatitis, tuberculosis.
2. the collection of Clinical blood pressure: when patient goes to a doctor, sits quietly 5 minutes, unified measurement right arm brachial arterial pressure, and elbow in the wrong and heart are positioned on same level line, stethoscope probe are placed in brachial artery fluctuation place, read systolic pressure and diastolic pressure.
3. adopt U.S. suntech medical oscar2tm Circadian blood pressure profile system to carry out 24 hours monitoring of blood pressure to object of study, oversleeve is unified is positioned over right arm, during monitoring, object of study avoids strenuous exercise or anxious state of mind, does not affect daily life, work.Monitoring time is unified for early 8:00-9:00 is to 8:00-9:00 next day.Advise experimenter when cuff inflation, keep tranquil, daytime, monitoring frequency was 30min/ time as far as possible.Night is 45min/ time.After monitoring terminates, use ambulatory blood pressure analysis software statistics.Liver heat removing kidney tonifying dispels the wind after Chinese medicine compound intervenes a course for the treatment of, advises experimenter to check 24h ambulatory blood pressure, concrete with before entering group.
4. hypertension animal model and intervention: with 4 week age cleaning grade SHR male rat for hypertension model group, average weight 109.2 ± 0.8g, with week age cleaning grade WKY male rat for Normal group, average weight 109.4 ± 1.9g.Regular diet, after adaptability raises one week, is divided into model group, Chinese drug-treated group, positive controls (amlodipine group, Candesartan group) at random.Chinese medicine (Rhizoma Chuanxiong 15g, Radix Bupleuri 15g, Rhizoma Coptidis 6g, Rhizoma Et Radix Notopterygii 15g, Radix Saposhnikoviae 15g, Spica Prunellae 30g, Radix Cyathulae 15g, Rhizoma Polygonati 15g, Concha Haliotidis 20g, Radix Scutellariae (parched) 15g, Herba Taxilli 15g) presses 6.3 times of human body consumption as Chinese medicine dosage.Amlodipine, Candesartan are all with 1mg/kg/d Rapid Dose Calculation.Chinese drug-treated group, positive controls be difference gavage 2ml/d in the 6th week, and Normal group and model group give isopyknic PBS, intervenes 14 weeks altogether.Animal was put to death when the 20th week age.
5. SHR rat systolic pressure, diastolic pressure: all laboratory animals, from the 6th week, use weekly tail platen press to measure rat blood pressure (BP-98A Series, Softron).During measurement, be fixed on by rat in Mus bag, keep constant temperature, sensor is placed in rat root of the tail portion, manual monitoring rat tails blood flow is pulsed, and measures 3 times, record rat average systolic, diastolic pressure.
6. SHR rat heart, kidney, cerebral morphology are observed: during 20 week age, the chloral hydrate anesthesia of all laboratory animal lumbar injections 10%, put to death animal, to core, brain, kidney, the paraformaldehyde of 4% is fixed, embedding, section, Hematoxylin-eosin dyes, the change of basis of microscopic observation pathomorphism, and according to having no obvious pathological change, slight pathology damage, moderate pathology damage, severe pathology damage, pole severe pathology damage, respectively labelling 0,1,2,3,4.Masson trichrome stain observes fibrosis, and use Image-Pro Plus 6.0 computed in software fibrosis area, and respectively the model group heart, renal fibrosis area standard are turned to 1, statistical analysis respectively organizes fibrosis area.
7. statistical analysis
Measurement data represents with mean ± standard deviation, meet the variance analysis (one-way-classification ANOVA) of the one-way classification of normal distribution and homogeneity of variance employing one factor analysis of variance, compare between two and use t inspection, as do not met normality and homogeneity of variance then represents with M, min, max, compare between group with Kruslal-Wallis H inspection.The Kruskal-Wallis H that the multiple sample of ranked data completely randomized design compares checks.
Two, result
1. preclinical is observed: observe hyperpietic's Western medicine early stage and control undesirable person 44 example, male 32 example, women 12 example; Prehypertensive 48 example, male 37 example, women 11 example.Hyperpietic gives liver heat removing kidney tonifying and to dispel the wind method treatment on original treatment basis, and prehypertensive person only gives liver heat removing kidney tonifying and to dispel the wind intervention; Sooner or later respectively once, oral, observe 6 months altogether.Invalid 5 examples, wherein hypertension 3 example, prehypertensive 2 example, its total effective rate is 94.57%.As shown in table 1, liver heat removing kidney tonifying dispel the wind Chinese medicine compound significantly reduce hyperpietic, prehypertensive patient systolic pressure and diastolic pressure (
p<0.05).
2. prehypertensive patient clinical essential information
Collect prehypertensive 20 example altogether as object of study, 47.75 ± 2.73 years old mean age, average BMI is 24.14 ± 0.48.As shown in table 2, no difference of science of statistics before and after the index treatments such as experimenter's glutamate pyruvate transaminase, carbamide, creatinine, uric acid, fasting glucose, triglyceride, cholesterol.
3. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind significantly reduces prehypertensive patient Clinical blood pressure:
As shown in table 3, prehypertensive patient clinic systolic pressure, diastolic pressure after liver heat removing kidney tonifying dispels the wind 1 course for the treatment of of compound of Chinese medicine all significantly reduce, have statistical significance (
p<0.05).
As shown in table 4, liver heat removing kidney tonifying dispels the wind after the course for the treatment of of compound of Chinese medicine, prehypertensive patient 24 hourly average systolic pressure, 24 hourly average diastolic pressures, 24 hours pulse pressure differences, daytime average systolic, daytime AvDP, daytime pulse pressure difference, night average systolic all significantly reduce (
p<0.05).
5. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind significantly reduces prehypertensive patients' blood load:
As shown in table 5, prehypertensive patient after liver heat removing kidney tonifying dispels the wind 1 course for the treatment of of compound of Chinese medicine, 24h systolic pressure load, daytime systolic pressure load, night systolic pressure load all significantly reduce (
p<0.05).
6. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind significantly reduces SHR systolic pressure level:
As shown in table 6, accompanying drawing 1, Normal group WKY rat systolic pressure, from vary stable in age week in 6 week age to 20, fluctuates between 120mmHg to 130mmHg.The contraction of model group SHR rat is pressed on the 6th week and starts to continue to rise, and can reach 208.75 ± 6.05mmHg to systolic pressure during 20 week age.Chinese drug-treated group blood pressure in the 8th week time has reduced about 10mmHg, during to 10 week age, Chinese drug-treated group significantly reduce SHR rat systolic pressure level (
p<0.05).During 20 week age, Chinese drug-treated group SHR rat systolic pressure fluctuates in 150 ~ 160mmHg.During age in amlodipine group, Candesartan group to 20 week, SHR rat systolic pressure all fluctuates between 130 ~ 140mmHg.
7. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind significantly reduces SHR diastolic pressure level:
As shown in table 7, accompanying drawing 2: during 6 week age, all laboratory animal diastolic pressures fluctuate upper and lower in 85mmHg, equal no significant difference.In age week in 8 week age to 20, the change of Normal group WKY rat diastolic pressure steadily, is fluctuated in about 100mmHg.Model group SHR rat diastolic pressure in the 8th week time continues to rise, and can reach 176.75 ± 4.76mmHg to diastolic pressure during 20 week age.Chinese drug-treated group significantly reduce SHR rat diastolic pressure level (
p<0.05), during 20 week age, its diastolic pressure all fluctuates between 130 ~ 140mmHg.During 20 week age, amlodipine group, Candesartan group SHR rat diastolic pressure level fluctuate between 110 ~ 120mmHg.
8. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind is remarkable to cardioprotection:
As depicted in figure 3 a, 20 week age, Normal group heart had no pathological change, the visible myocardium multiple focal necrosis of model group, massive inflammatory cells infiltrated, congestion and edema between muscle fiber; The rarely seen micro-myocardial necrosis of Chinese drug-treated group and cell infiltration; Congestion and edema between amlodipine group visible muscle fiber, cell infiltration, the multiple collections necrosis of cardiac muscle; The visible myocardium collections necrosis of Candesartan group, cell infiltration.As shown in fig. 3b, Chinese drug-treated group significantly reduce cardiomyopathy rationality change, and be significantly better than amlodipine group (
p<0.05).
9. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind significantly reduces myocardial vascular surrounding annulus area:
As shown in accompanying drawing 4a, visible normal fiber degree around 20 week age Normal group myocardial vascular, model group perivascular fibrosis obviously increases, and Chinese drug-treated group, amlodipine group, Candesartan group are all shown in a small amount of fibrosis around myocardial vascular.Use Image-Pro Plus 6.0 computed in software to add up each group of perivascular fibrosis area, Normal group myocardial vascular surrounding annulus area standard turned to 1, as depicted in fig. 4b, Chinese drug-treated group significantly reduce myocardial vascular surrounding annulus area (
p<0.05), compared with positive controls, have no notable difference.
10. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind is remarkable to Renoprotective Effect:
As shown in accompanying drawing 5a, 20 week age, Normal group renal tissue HE dyeing had no the change of obvious pathologic, and the infiltration (model group-1) of the visible renal interstitial inflammatory cell of model group SHR rat, mucous membrane of renal pelvis epithelial damage comes off (model group-2).The infiltration of a small amount of inflammatory cell of all rarely seen renal interstitial of Chinese drug-treated group, Candesartan group.The visible coagulation necrosis of amlodipine group renal interstitial.Be divided into according to renal tissue lesion degree and have no the change of obvious pathologic, slight pathological changes, moderate pathological changes, severe pathological changes, be labeled as 0,1,2,3,4 point respectively.As shown in fig. 5b: Chinese drug-treated group significantly improve kidney damage (
p<0.05), and be significantly better than amlodipine group (
p<0.05).
11. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind significantly reduces kidney region fibrosis area:
As shown in fig. 6,20 week age, Normal group WKY rat kidney tissue had no fibrosis change, there is large-area fibrosis in model group SHR kidney of rats interstitial, Chinese drug-treated group, Candesartan group renal interstitial surrounding annulus area obviously reduce, the visible large-area fibrosis of amlodipine group.Each group of renal fibrosis area is added up by Image-Pro Plus 6.0 computed in software, model group SHR kidney of rats interstitial surrounding annulus area standard is turned to 1, as shown in fig. 6b, compared with model group, Chinese drug-treated group significantly reduce renal interstitial surrounding annulus area (
p<0.05), and, compared with amlodipine group, Chinese drug-treated group significantly reduce renal interstitial surrounding annulus (
p<0.05).
12. liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind is remarkable to cerebral tissue protective effect:
As shown in accompanying drawing 7a, 20 week age, Normal group WKY rat cerebral tissue showed no obvious abnormalities; The visible intracranial hemorrhage of model group SHR rat (model group-1), meningovascular dilatation and congestion (model group-2); The all rarely seen meningovascular dilatation and congestion of Chinese drug-treated group, amlodipine group, Candesartan group.According to congested, extent of hemorrhage be divided into have no the change of obvious pathologic, light, in, heavy, extremely heavy, labelling 0,1,2,3,4 respectively.As shown in accompanying drawing 7b, Chinese drug-treated group significantly reduces meningovascular dilatation and congestion degree, and be significantly better than amlodipine, Candesartan (
p<0.05).
The present invention is based on the basis of observation in early stage, liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind is intervened prehypertensive patient and studied, result of study discloses, liver heat removing kidney tonifying Chinese medicine compound of dispeling the wind not only significantly reduces prehypertensive patient systolic pressure, diastolic pressure level, and significantly reduces prehypertensive patient systolic pressure load.And the present invention discloses in animal experiment study; liver heat removing kidney tonifying Chinese medicine compound early intervention of dispeling the wind significantly can reduce SHR rat systolic pressure, diastolic pressure level; delay the lasting rising of SHR rat blood pressure, and to the caused by hypertension heart, brain, kidney target organ damage, there is significant protective effect.This research disclose first liver heat removing kidney tonifying dispel the wind the significant hypotensive effect of Chinese medicine compound and to target organs of patients with essential hypertension infringement protective effect, for hypertensive control and to target organs of patients with essential hypertension infringement protective effect brand-new thinking is provided.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (5)
1. prevent and treat the Chinese medicine composition of hypertension, the infringement of protection target organs of patients with essential hypertension for one kind; it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 10-20 part, Radix Bupleuri 10-20 part, Rhizoma Coptidis 3-9 part, Rhizoma Et Radix Notopterygii 10-20 part, Radix Saposhnikoviae 10-20 part, Spica Prunellae 20-40 part, Radix Cyathulae 10-20 part, Rhizoma Polygonati 10-20 part, Concha Haliotidis 15-25 part, Radix Scutellariae (parched) 10-20 part, Herba Taxilli 10-20 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 13-17 part, Radix Bupleuri 13-17 part, Rhizoma Coptidis 5-7 part, Rhizoma Et Radix Notopterygii 13-17 part, Radix Saposhnikoviae 13-17 part, Spica Prunellae 27-33 part, Radix Cyathulae 13-17 part, Rhizoma Polygonati 13-17 part, Concha Haliotidis 17-23 part, Radix Scutellariae (parched) 13-17 part, Herba Taxilli 13-17 part.
3. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Rhizoma Coptidis 6 parts, Rhizoma Et Radix Notopterygii 15 parts, Radix Saposhnikoviae 15 parts, Spica Prunellae 30 parts, Radix Cyathulae 15 parts, Rhizoma Polygonati 15 parts, Concha Haliotidis 20 parts, Radix Scutellariae (parched) 15 parts, Herba Taxilli 15 parts.
4. according to the application of the arbitrary described Chinese medicine composition of claim 1-3 in the medicine of preparation prophylaxis of hypertension.
5. according to the application of the arbitrary described Chinese medicine composition of claim 1-3 in the medicine of preparation protection target organs of patients with essential hypertension infringement.
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