CN104398795B - It is a kind of to prevent and treat hypertension, the Chinese medicine composition of protection target organs of patients with essential hypertension infringement and its application - Google Patents
It is a kind of to prevent and treat hypertension, the Chinese medicine composition of protection target organs of patients with essential hypertension infringement and its application Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition prevented and treated hypertension, protect target organs of patients with essential hypertension infringement, described Chinese medicine composition is made up of following bulk drug：Ligusticum wallichii, radix bupleuri, the coptis, notopterygium root, windproof, selfheal, radix cyathulae, sealwort, the shell of seaear, stir-baked RADIX SCUTELLARIAE, Ramulus Taxilli.The present invention also provides the application of the Chinese medicine composition.Its advantage is shown：The Chinese medicine composition of the present invention significantly improves prehypertensive patients' blood's index；Significantly reduce SHR rats systolic pressure, diastolic pressure level, it is often more important that there is significant protective effect to the heart, brain, kidney target organ damage.The Chinese medicine composition early intervention hypertension of the present invention not only delays the process of hypertension, it is often more important that the protective effect damaged to target organs of patients with essential hypertension, can be widely popularized in clinic, delays the infringement of target organ, improves the quality of life of patient.
Description
Technical field
It is that one kind prevents and treats hypertension, protection target organs of patients with essential hypertension infringement specifically the present invention relates to technical field of pharmaceuticals
Chinese medicine composition and its application.
Background technology
Hypertension（hypertension）Refer under quiescent condition, systolic pressure and/or diastolic pressure increase（≥140mmHg/
90mmHg）, it is often accompanied by the target organ such as disorders of lipid metabolism and the heart, brain, kidney and retina function or organic change.Systolic pressure exists
Between 120 ~ 139mmHg and/or diastolic pressure between 80 ~ 89mmHg be prehypertensive or normal high level.
Hypertension is most common cardiovascular disease, is the great public health problem in global range.Epidemiology survey
It has been shown that, China 18 years old and above prevalence of hypertension rate are 18.8%, and the national number of patients of estimation is more than 1.6 hundred million.The high blood of China
Press guideline of prevention and treatment（Revised edition in 2010）Point out：Annual China just has newly-increased hyperpietic 10,000,000 in every 5 adults
1 suffers from hypertension, and cri dernier cri disease learns investigation and shows in about every 3 adults in the U.S. just there is 1 hyperpietic.Before hypertension
Phase is that hypertension is most important " hidden danger crowd ".The urban population of China about 59.31% is in the prehypertensive stage, about
44.15% people in the countryside be prehypertensive, and research show：Blood pressure 120 ~ 129/80 ~ 84mmHg and 130 ~ 139/85 ~
90mmHg middle-aged population, be changed into the probability of hypertension after 10 years has 45% and 64% respectively.Epidemiological study is shown, with blood
Positive pressure ordinary person compares, and the probability that apoplexy occurs for prehypertensive adds 1.66 times, and the probability for occurring ESRD is added
1.59 times, the incidence of angiocardiopathy adds 2.0 times.Therefore, early intervention, can effectively delay the process of hypertension,
More importantly delay the infringement of target organ, improve the quality of life of patient.
Ligusticum wallichii（Chuanxiong）For samphire Ligusticum wallichii Ligusticum chuanxiong Hort. rhizome.Taste
It is pungent, warm-natured, Return liver, courage, pericardium channel.With blood-activating and qi-promoting, effect of wind-expelling pain-stopping.Demonstrate,proved available for stagnation of QI and blood pain, headache, wind
Arthritis with fixed pain caused by dampness pain etc..
Radix bupleuri（Chaihu）For umbelliferae bupleurum BupLeurum chinensis DC. or radix bupleuri scorzoneraefolii
BupLeurum scorzonerifolium Willd. dry root.Bitter, pungent, cold nature.Return liver, gallbladder channel.Moved back with inducing diaphoresis
Heat, soothing liver-qi stagnation rises the effect for lifting yang-energy.Available for exterior syndrome heating and shaoyang disease, stagnation of QI due to depression of the liver, collapse from qi deficiency, internal organs prolapsus
Deng.
The coptis（Huanglian）For ranunculaceae plant coptis CopTis chinensis Franch., triangle leaf coptis C.
Deltoidea C.Y.Cheng et Hsiao or cloud connect C. teeta Wall. dry rhizome.Bitter, cold in nature, the thoughts of returning home, spleen,
Stomach, courage, large intestine channel.With heat-clearing and damp-drying drug, effect of purging intense heat and detonicating.Available for damp and hot feeling of fullness, vomiting acid regurgitation, damp-heat dysentery is high
Hot coma, dysphoria and insomnia, blood-head tells nosebleed, carbuncle swells furuncle sore, hot eyes toothache is quenched one's thirst, eczema, wet sore, duct is controlled outside and is suppurated.
Notopterygium root（Qianghuo）For samphire notopterygium root Notopterygium incisum Tncisum Ting ex
H.Chang or notopterygium forbesii NotopTerygium forbesii Boiss. dry rhizome and root.Pungent, hardship, it is warm-natured, return
Bladder, kidney channel.With relieving exterior syndrome and dispelling cold, expelling wind and eliminating dampness, effect of analgesic.Available for anemofrigid cold, wind-cold-dampness arthralgia etc..
It is windproof（Fangfeng）For umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata(Turez.)
Schischk. root.Pungent, sweet, slightly warm in nature returns bladder, liver, the spleen channel.With expelling pathogenic wind from the body surface, the work(of expel endogenous wind to relieve convulsion, only convulsion
Effect.Available for diseases caused by external factors exterior syndrome, rubella itch, arthralgia pain due to rheumatism, additionally available for interior wind is put out to stop convulsion, also available for insufficiency of the spleen wet
Contain, diarrhea caused by lucid yang failing to raise etc..
Selfheal（Xiakucao）For labiate selfhealPRunella vulgaris L. drying fruit ear.Taste
Pungent, hardship, cold in nature, Return liver, gallbladder channel.With clearing heat-fire, improving eyesight, effect of mass dissipating and swelling eliminating.It is dizzy available for red eye, swell pain, headache
Dizzy, mesh pearl nyctalgia, scrofula, goiter and tumor, acute mastitis swells and ache.
Radix cyathulae（Chuanniuxi）For radix cyathulae (RADIX CYATHULAE) Cyathula officinalis Kuan root.Bitter,
Sweet, acid, it is mild-natured, return liver and kidney channel.With invigorate blood circulation, filling liver kidney, strengthening the bones and muscles, promoting diuresis for stranguria is ignited（Blood）Descending effect.
Available for the Amenorrhea of stagnation of blood stasis, dysmenorrhoea, dysmenorrhea, placenta retension and the pain of injury caused by falling and tumbling, soreness of waist and knee joint, flaccidity and weakness of the lower limbs, stranguria,
Oedema, difficult urination, burning hot upper inflammation, fire excess from yin deficiency headache, dizziness, dentalgia, aphthae, haematemesis, bleeding from five sense organs or subcutaneous tissue etc..
Sealwort（Huangjing）For liliaceous plant sealwortPOlygonatum sibiricum Red., P. kingianumP.kingianum Coll.et Hemsl. or David's-harpP.cyrtonema Hua rhizome.It is sweet, it is mild-natured, returns spleen, lung,
Kidney channel.With boosting qi and nourishing yin, invigorating the spleen, moistening lung, effect of kidney-nourishing.Available for the lung-dryness syndrome due to yin deficiency, the labor of the few phlegm of dry cough and lung-kidney deficiency
Cough chronic cough, insufficiency of the spleen impairment of yin card, deficiency of kidney-essence etc..
The shell of seaear（Shijueming）For Bao Ke animal Haliotis diversicolors（Light bedstone Cassia）Haliotis diversicolor
Reeve, haliotis discus hannai Ino（Hair bedstone Cassia）Haliotis discus hannai Ino, sheep Bao Haliotis ovina
Gmelin, haliotis ruber Haliotis ruber (Leach), ear Bao Haliotis asinina Linnaeus or white Baos
Haliotis laevigata (Donovan) shell.Taste is salty, cold in nature, return liver warp.With calming the liver, clear liver and improve vision
Effect.Available for liver-yang hyperactivity, have a dizzy spell, hot eyes, ocular, blurring of vision etc..
Radix scutellariae（Huangqin）For labiate radix scutellariae Scutellaria baicalensis Georgi drying
Root.Bitter, cold in nature, return lung, courage, spleen, stomach, large intestine, small intestinl channel.With heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive effect.
Available for damp-warm syndrome, summer-heat and damp, evil of vomitting uncomfortable in chest, damp and hot feeling of fullness, jaundice rush down dysentery, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle swells sore
Poison, fetal irritability etc..
Ramulus Taxilli（Sangjisheng）For Loranthaceae plant Ramulus Taxilli Taxillus chinensis (DC.)
Danser drying stem and branch with leaf.It is bitter, sweet, it is mild-natured, return liver and kidney channel.It is wet with evacuate pathogenic wind, filling liver kidney, strengthening the bones and muscles, antiabortive work(
Effect.Available for rheumatism bi Zheng, uterine bleeding passes through many, blood leaking in gestation, fetal irritability, in addition, still can hypotensive, available for high blood pressure
Deng.
But hypertension, the Chinese medicine composition of protection target organs of patients with essential hypertension infringement and its application are prevented and treated on the present invention,
It yet there are no report.
The content of the invention
The purpose of the present invention is to be directed to deficiency of the prior art to prevent and treat hypertension, protection hypertension target device there is provided one kind
The Chinese medicine composition of official's infringement.
Another purpose of the present invention is to provide a kind of Chinese medicine group prevented and treated hypertension, protect target organs of patients with essential hypertension infringement
The application of compound.
To achieve the above object, the present invention is adopted the technical scheme that：One kind prevents and treats hypertension, protection target organs of patients with essential hypertension
The Chinese medicine composition of infringement, described Chinese medicine composition is made up of the bulk drug of following parts by weight：10-20 parts of Ligusticum wallichii, radix bupleuri 10-
20 parts, 3-9 parts of the coptis, 10-20 parts of notopterygium root, windproof 10-20 parts, 20-40 parts of selfheal, 10-20 parts of radix cyathulae, sealwort 10-20
Part, 15-25 parts of the shell of seaear, 10-20 parts of stir-baked RADIX SCUTELLARIAE, 10-20 parts of Ramulus Taxilli.
Described Chinese medicine composition is made up of the bulk drug of following parts by weight：13-17 parts of Ligusticum wallichii, 13-17 parts of radix bupleuri, the coptis
5-7 parts, 13-17 parts of notopterygium root, windproof 13-17 parts, 27-33 parts of selfheal, 13-17 parts of radix cyathulae, 13-17 parts of sealwort, the shell of seaear
17-23 parts, 13-17 parts of stir-baked RADIX SCUTELLARIAE, 13-17 parts of Ramulus Taxilli.
Described Chinese medicine composition is made up of the bulk drug of following parts by weight：15 parts of Ligusticum wallichii, 15 parts of radix bupleuri, 6 parts of the coptis, Qiang
15 parts living, windproof 15 parts, 30 parts of selfheal, 15 parts of radix cyathulae, 15 parts of sealwort, 20 parts of the shell of seaear, 15 parts of stir-baked RADIX SCUTELLARIAE, Ramulus Taxilli 15
Part.
To realize above-mentioned second purpose, the present invention is adopted the technical scheme that：Described Chinese medicine composition is being prepared in advance
Application in the medicine of anti-hypertension.
Application of the described Chinese medicine composition in the medicine for preparing protection target organs of patients with essential hypertension infringement.
The invention has the advantages that：
The Chinese medicine composition of the present invention（Clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription）Significantly reduce prehypertensive patient systolic pressure,
Diastolic pressure level and 24h, daytime, night average systolic, diastolic pressure level, and significantly reduce prehypertensive patient 24h, it is white
Daytime, night systolic pressure load.This result provides brand-new means of prevention for the early intervention of hypertension.Meanwhile, the present invention is adopted
Use male spontaneous hypertensive rat（SHR）As hypertension model, research and inquirement clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is big to SHR
The control of mouse blood pressure and its protective effect to target organ.Result of study shows：Clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is significantly reduced
SHR rats systolic pressure, diastolic pressure level, it is often more important that there is significant protective effect to the heart, brain, kidney target organ damage.Clearly
Liver kidney-nourishing wind-dispelling Chinese medicine compound prescription early intervention hypertension not only delays the process of hypertension, it is often more important that to target organs of patients with essential hypertension
The protective effect of infringement, early prevention and treatment for hypertension and its protective effect damaged to target organs of patients with essential hypertension provide controlling completely newly
Treatment means, can effectively instruct clinical application, delay the infringement of target organ, improve the quality of life of patient.
Brief description of the drawings
Accompanying drawing 1,2. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescriptions significantly reduce SHR rats systolic pressure, diastolic pressure level：4 week old
SHR male rats after adaptability is raised one week, are randomly divided into model group, Chinese medicine as hypertension animal model, regular diet
Group, positive controls（Amlodipine group, Candesartan group）.Using same week old WKY male rats as Normal group.In the 6th week
Pharmaceutical intervention is given during age respectively, is intervened 14 weeks altogether.Weekly using tail platen press measurement rat systolic pressure, diastolic pressure.Such as accompanying drawing 1,2
Shown, compared with Normal group, model group SHR rats systolic pressure, diastolic pressure are persistently raised with week old change blood pressure；With model
Group is compared, and Chinese medicine group significantly reduces SHR rats systolic pressure, diastolic pressure（p<0.05）.
Accompanying drawing 3a, 3b, 4a, 4b. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is notable to SHR rat heart protective effects：All realities
Animal is tested when 20 week old, animal, dirty carry out pathological observation of coring is put to death.It is main to use paraffin section, Hematoxylin-eosin dye
Color, the change of micro- Microscopic observation pathomorphism.Masson trichrome stains observe fibrosis.As shown in accompanying drawing 3a, 3b, with
Normal group is compared, the visible myocardium multiple focal necrosis of model group, massive inflammatory cells infiltrated, congested water between muscle fibre
It is swollen；Compared with model group, Chinese medicine group significantly reduces cardiac muscular tissue's focal necrosis（p<0.05）, and it is significantly better than Amlodipine group（p
<0.05）.In accompanying drawing 3b, compared with model group, *p<0.05, compared with Amlodipine group, ▲p<0.05.Such as accompanying drawing 4a, 4b institute
Show, compared with Normal group, model group myocardial vascular surrounding annulusization significantly increases；Compared with model group, Chinese medicine group is notable
Reduce myocardial vascular surrounding annulus area（p<0.05）.In accompanying drawing 4b, compared with normal group, #p<0.05；With model group ratio
Compared with *p<0.05。
Accompanying drawing 5a, 5b, 6a, 6b. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is notable to SHR rat kidney protective effects：20 weeks
During age, animal is put to death, takes kidney to carry out pathological observation.It is main to use paraffin section, the dyeing of row Hematoxylin-eosin and Masson
Trichrome stain.As shown in accompanying drawing 5a, 5b, compared with Normal group, the visible renal interstitial inflammatory of model group SHR rat kidney tissues
The infiltration of cell（Model group -1）, mucous membrane of renal pelvis epithelial damage comes off（Model group -2）.Chinese medicine group is significantly reduced between SHR Rat renals
Matter inflammatory cell infiltration（p<0.05）.In accompanying drawing 5b, compared with model group, *p<0.05, compared with Amlodipine group, ▲p<
0.05.As shown in accompanying drawing 6a, 6b, Chinese medicine group significantly reduces SHR renal interstitial fibrosis rat degree, and is significantly better than Amlodipine
Group（p<0.05）.In accompanying drawing 6b, compared with model group, *p<0.05, compared with Amlodipine group, ▲p<0.05。
Accompanying drawing 7a, 7b. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is notable to the protective effect of SHR rat cerebral tissues：During 20 week old,
Animal is put to death, takes brain tissue to carry out pathological observation.It is main to use paraffin section, the dyeing of row Hematoxylin-eosin.Such as accompanying drawing 7a,
Shown in 7b, compared with Normal group, model group rats brain tissue is visible to intracranial hemorrhage（Model group -1）, meningovascular expansion fill
Blood（Model group -2）.Chinese medicine group（CM）Rarely seen meningovascular dilatation and congestion, and lesion degree is substantially less than Amlodipine group, candy
Sha Tan groups（p<0.05）.In accompanying drawing 7b, compared with model group, *p<0.05, compared with Amlodipine group, ▲p<0.05, with candy
Sha Tan groups are compared, ◆p<0.05。
Embodiment
The embodiment that the present invention is provided is elaborated below in conjunction with the accompanying drawings.
It is a kind of to prevent and treat hypertension, the Chinese medicine composition of protection target organs of patients with essential hypertension infringement, described Chinese medicine composition by with
The bulk drug of lower parts by weight is made：10-20 parts of Ligusticum wallichii, 10-20 parts of radix bupleuri, 3-9 parts of the coptis, 10-20 parts of notopterygium root, windproof 10-20
Part, 20-40 parts of selfheal, 10-20 parts of radix cyathulae, 10-20 parts of sealwort, 15-25 parts of the shell of seaear, 10-20 parts of stir-baked RADIX SCUTELLARIAE, Ramulus Taxilli
10-20 parts.
The Chinese medicine composition of embodiment 1
15 parts of Ligusticum wallichii, 15 parts of radix bupleuri, 6 parts of the coptis, 15 parts of notopterygium root, windproof 15 parts, it is 30 parts of selfheal, 15 parts of radix cyathulae, yellow
15 parts of essence, 20 parts of the shell of seaear, 15 parts of stir-baked RADIX SCUTELLARIAE, 15 parts of Ramulus Taxilli.
The Chinese medicine composition of embodiment 2
13 parts of Ligusticum wallichii, 17 parts of radix bupleuri, 5 parts of the coptis, 13 parts of notopterygium root, windproof 17 parts, it is 27 parts of selfheal, 17 parts of radix cyathulae, yellow
13 parts of essence, 23 parts of the shell of seaear, 13 parts of stir-baked RADIX SCUTELLARIAE, 17 parts of Ramulus Taxilli.
The Chinese medicine composition of embodiment 3
17 parts of Ligusticum wallichii, 13 parts of radix bupleuri, 7 parts of the coptis, 17 parts of notopterygium root, windproof 13 parts, it is 33 parts of selfheal, 13 parts of radix cyathulae, yellow
17 parts of essence, 17 parts of the shell of seaear, 17 parts of stir-baked RADIX SCUTELLARIAE, 13 parts of Ramulus Taxilli.
The Chinese medicine composition of embodiment 4
10 parts of Ligusticum wallichii, 20 parts of radix bupleuri, 3 parts of the coptis, 20 parts of notopterygium root, windproof 10 parts, it is 20 parts of selfheal, 20 parts of radix cyathulae, yellow
10 parts of essence, 15 parts of the shell of seaear, 20 parts of stir-baked RADIX SCUTELLARIAE, 10 parts of Ramulus Taxilli.
The Chinese medicine composition of embodiment 5
20 parts of Ligusticum wallichii, 10 parts of radix bupleuri, 9 parts of the coptis, 10 parts of notopterygium root, windproof 20 parts, it is 40 parts of selfheal, 10 parts of radix cyathulae, yellow
20 parts of essence, 25 parts of the shell of seaear, 10 parts of stir-baked RADIX SCUTELLARIAE, 20 parts of Ramulus Taxilli.
The preparation of the Chinese medicine composition of embodiment 6
The pharmaceutical dosage form that any described Chinese medicine compositions of embodiment 1-5 are prepared by conventional formulation means.
The clinical test of embodiment 7, animal experiment
In the present embodiment, on the basis of based on early stage observation, Clinical Hypertension early stage patient 20 is collected, is given clear
Liver kidney-nourishing wind-dispelling method（The Chinese medicine composition of embodiment 1）Intervene 1 course for the treatment of（6 months）, respectively to Clinical blood pressure, the dynamic blood of 24h
Pressure is studied, and inquires into and clearly clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription not only significantly reduces systolic pressure, diastolic pressure, and significantly drop
Lower shrinkage presses load.Also, in the present embodiment, we are used as hypertension animal model, research using 4 week old SHR rats
And clearly clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription can significantly reduce SHR rats systolic pressure, diastolic pressure, and to the caused by hypertension heart,
Brain, kidney target organ damage have significant protective effect.It is significant that this research discloses clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription first
Antihypertensive effect and its protective effect damaged to target organs of patients with essential hypertension, are the preventing and treating of hypertension and target organs of patients with essential hypertension are damaged
Protective effect provides brand-new thinking.
First, method
1. clinical research sample is collected
Clinical sample for the present invention all is from the court, and all research objects are all conscientiously read and sign informed
Letter of consent, meets ethical standard.Research object is male, and the age is between 30-60 Sui.Antihypertensive drugs is being not used
In the case of, non-three measurements on the same day, 120 ~ 139mmHg of systolic pressure and/or diastolic pressure are prehypertensive in 80 ~ 89mmHg.
All research objects are previously without other angiocardiopathies, serious liver and kidney dysfunction, diabetes, the infectiousness such as hepatitis, tuberculosis
Disease.
2. the collection of Clinical blood pressure：When patient goes to a doctor, sit quietly 5 minutes, unified measurement right arm brachial arterial pressure, bend elbow with
Heart is located in same horizontal line, and stethoscope probe is placed at arteria brachialis fluctuation, reads systolic pressure and diastolic pressure.
3. 24 are carried out to research object using U.S.'s suntech medical oscar2tm Circadian blood pressure profiles systems
Hour monitoring of blood pressure, research object avoids strenuous exercise or anxious state of mind during oversleeve is uniformly positioned over right arm, monitoring, does not influence
Daily life, work.It is early 8 to monitor time unification:00-9:00 to next day 8:00-9:00.Subject is advised in cuff inflation
When, keep tranquil as far as possible, daytime monitoring frequency is 30min/ times.Night is 45min/ times.After monitoring terminates, ambulatory blood pressure is used
Analysis software is counted.Clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is intervened after a course for the treatment of, advises subject to check 24h ambulatory blood pressures,
It is specific to enter before group together.
4. hypertension animal model and intervention：Using 4 week old cleaning grade SHR male rats as hypertension model group, average body
109.2 ± 0.8g is weighed, using same week old cleaning grade WKY male rats as Normal group, 109.4 ± 1.9g of average weight.It is conventional
Diet, after adaptability is raised one week, is randomly divided into model group, Chinese medicine group, positive controls（Amlodipine group, Candesartan
Group）.Chinese medicine（Ligusticum wallichii 15g, radix bupleuri 15g, coptis 6g, notopterygium root 15g, windproof 15g, selfheal 30g, radix cyathulae 15g, sealwort 15g,
Shell of seaear 20g, stir-baked RADIX SCUTELLARIAE 15g, Ramulus Taxilli 15g）6.3 times of human body consumption are pressed as Chinese medicine dosage.Amlodipine, candy
It is husky smooth with 1mg/kg/d Rapid Dose Calculations.Chinese medicine group, positive controls in the 6th week respectively gavage 2ml/d, Normal group with
Model group gives isometric PBS, intervenes 14 weeks altogether.Animal is put to death when 20 week old.
5. SHR rats systolic pressure, diastolic pressure：All experimental animals were from the 6th week, weekly using tail platen press measurement rat
Blood pressure (BP-98A Series, Softron).During measurement, rat is fixed in mouse bag, constant temperature is kept, receptor is placed in
Rat root of the tail portion, manual monitoring rat tailses blood flow pulsation, is measured 3 times, record rat average systolic, diastolic pressure.
6. SHR rat hearts, kidney, cerebral morphology are observed：During 20 week old, all experimental animal intraperitoneal injections 10%
Chloral hydrate anesthesia, put to death animal, core, brain, kidney, 4% paraformaldehyde is fixed, embed, section, Hematoxylin-eosin dye
Color, the change of micro- Microscopic observation pathomorphism, and according to have no obvious pathological change, slight pathology damage, moderate pathology damage
Wound, severe pathology damage, pole severe pathology damage, respectively mark 0,1,2,3,4.Masson trichrome stains observe fibrosis journey
Degree, fibrosis area is calculated using the softwares of Image-Pro Plus 6.0, and respectively by the model group heart, kidney fibrosis area mark
Standard turns to 1, statistical analysis each group fibrosis area.
7. statistical analysis
Measurement data is represented with mean ± standard deviation, meets normal distribution and homogeneity of variance using one-way analysis of variance
The variance analysis of one-way classification（one-way-classification ANOVA）, compare examined using t two-by-two, do not meet such as just
State property and homogeneity of variance are then represented with M, min, max, are compared between group and are examined with Kruslal-Wallis H.Ranked data are finished
The Kruskal-Wallis H that the complete multiple samples of Random Design compare are examined.
2nd, result
1. preclinical is observed：Early stage observation hyperpietic Western medicine controls undesirable person 44, male 32, women
12；Prehypertensive 48, male 37, women 11.Hyperpietic gives clearing liver kidney-nourishing on the basis of original treatment
Wind-dispelling method is treated, and prehypertensive person is given only clearing liver kidney-nourishing wind-dispelling intervention；Once in the morning and once at night, orally, observe 6 months altogether.Nothing
Effect 5, wherein hypertension 3, prehypertensive 2, its total effective rate is 94.57%.As shown in table 1, in the wind-dispelling of clearing liver kidney-nourishing
Medicine compound significantly reduces hyperpietic, prehypertensive patient systolic pressure and diastolic pressure（p<0.05）.
2. prehypertensive patient clinical essential information
Prehypertensive 20 is collected altogether as research object, average age 47.75 ± 2.73 years old, average BMI is
24.14±0.48.As shown in table 2, subject's glutamic-pyruvic transaminase, urea, creatinine, uric acid, fasting blood-glucose, triglycerides, courage are solid
No difference of science of statistics before and after the treatment of the indexs such as alcohol.
3. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription significantly reduces prehypertensive patient's Clinical blood pressure：
As shown in table 3, prehypertensive patient shrinks in clinic after clearing liver kidney-nourishing wind-dispelling 1 course for the treatment of of compound of Chinese herbal medicine
Pressure, diastolic pressure are significantly reduced, with statistical significance（p<0.05）.
4. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription significantly reduces prehypertensive analysis of ambulatory blood pressure：
As shown in table 4, after one course for the treatment of of clearing liver kidney-nourishing wind-dispelling compound of Chinese herbal medicine, the hourly average of prehypertensive patient 24
Systolic pressure, 24 hourly average diastolic pressures, 24 hours pulse pressure differences, daytime average systolic, daytime AvDP, daytime pulse pressures
Difference, night average systolic are significantly reduced（p<0.05）.
5. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription significantly reduces prehypertensive patients' blood's load：
As shown in table 5, prehypertensive patient is in after clearing liver kidney-nourishing wind-dispelling 1 course for the treatment of of compound of Chinese herbal medicine, 24h systolic pressures
Load, daytime systolic pressure load, night systolic pressure load are significantly reduced（p<0.05）.
6. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription, which significantly reduces SHR, shrinks voltage levels：
As shown in table 6, accompanying drawing 1, Normal group WKY rats systolic pressure changes stable from 6 week old to 20 week old, fluctuate in
120mmHg is between 130mmHg.Model group SHR rats, which shrink to be pressed on the 6th week, starts lasting rising, to systolic pressure during 20 week old
Up to 208.75 ± 6.05mmHg.Chinese medicine group blood pressure when the 8th week has reduced about 10mmHg, and during to 10 week old, Chinese medicine group is notable
Reduce SHR rats and shrink voltage levels（P<0.05）.During 20 week old, Chinese medicine group SHR rat systolic pressures are fluctuated in 150 ~ 160mmHg.
When Amlodipine group, Candesartan group to 20 week old, SHR rat systolic pressures are fluctuated between 130 ~ 140mmHg.
7. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription significantly reduces SHR diastolic pressure levels：
As shown in table 7, accompanying drawing 2：During 6 week old, all experimental animal diastolic pressures are fluctuated in above and below 85mmHg, without substantially poor
It is different.8 week old to 20 week old, Normal group WKY rats diastolic pressure change is steady, fluctuates in 100mmHg or so.Model group SHR
Rat diastolic pressure when the 8th week persistently rises, to diastolic pressure during 20 week old up to 176.75 ± 4.76mmHg.Chinese medicine group significantly drops
Low SHR rats diastolic pressure level（p<0.05）, its diastolic pressure is fluctuated between 130 ~ 140mmHg during 20 week old.During 20 week old,
Amlodipine group, Candesartan group SHR rat diastolic pressure levels are fluctuated between 110 ~ 120mmHg.
8. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is notable to cardioprotection：
As depicted in figure 3 a, 20 week old Normal group hearts have no pathological change, the visible myocardium multiple stove of model group
Property necrosis, massive inflammatory cells infiltrated, congestion and edema between muscle fibre；Chinese medicine group rarely seen micro myocardial necrosis and cell infiltration；
Congestion and edema between the visible muscle fibre of Amlodipine group, cell infiltration, the multiple collections necrosis of cardiac muscle；The visible heart of Candesartan group
The collections necrosis of flesh, cell infiltration.As shown in fig. 3b, Chinese medicine group substantially reduces the change of cardiomyopathy rationality, and significantly excellent
In Amlodipine group（p<0.05）.
9. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription significantly reduces myocardial vascular surrounding annulus area：
As shown in accompanying drawing 4a, visible normal fiber degree, model group blood around 20 week old Normal group myocardial vasculars
Pipe surrounding annulusization substantially increases, and Chinese medicine group, Amlodipine group, Candesartan group are shown in a small amount of fibrosis around myocardial vascular.
Using the software counting statistics each group perivascular fibrosis areas of Image-Pro Plus 6.0, by the myocardium blood of Normal group
Pipe surrounding annulus area standard turns to 1, as depicted in fig. 4b, and Chinese medicine group significantly reduces myocardial vascular surrounding annulus area
（p<0.05）, compared with positive controls, have no notable difference.
10. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is notable to Renoprotective Effect：
As shown in accompanying drawing 5a, 20 week old Normal group renal tissue HE dyeing has no obvious pathologic change, model group
The infiltration of the visible renal interstitial inflammatory cell of SHR rats（Model group -1）, mucous membrane of renal pelvis epithelial damage comes off（Model group -2）.Chinese medicine
The infiltration of the rarely seen a small amount of inflammatory cell of renal interstitial of group, Candesartan group.The visible coagulation necrosis of Amlodipine group renal interstitial.Root
Be divided into according to renal tissue lesion degree have no obvious pathology sexually revise, slight lesion, moderate lesion, severe lesion, mark respectively
For 0,1,2,3,4 points.As shown in fig. 5b：Chinese medicine group significantly improves kidney damage（p<0.05）, and it is significantly better than Amlodipine
Group（p<0.05）.
11. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription significantly reduces kidney region fibrosis area：
As shown in fig. 6,20 week old Normal group WKY rat kidney tissues have no that fibrosis changes, model group SHR
There is the fibrosis of large area in rat renal interstitial, and Chinese medicine group, Candesartan group renal interstitial surrounding annulus area are significantly reduced, ammonia
The fibrosis of the visible large area of Flordipine group.With the software counting statistics each group renal fibrosis faces of Image-Pro Plus 6.0
Product, 1 is turned to by model group SHR rat renal interstitial surrounding annulus area standards, as shown in fig. 6b, compared with model group, in
Medicine group significantly reduces renal interstitial surrounding annulus area（p<0.05）, also, compared with Amlodipine group, Chinese medicine group significantly drops
Low renal interstitial surrounding annulus（p<0.05）.
12. clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription is notable to brain tissue protective effect：
As shown in accompanying drawing 7a, 20 week old Normal group WKY rat cerebral tissues show no obvious abnormalities；Model group SHR rats
It can be seen that intracranialing hemorrhage（Model group -1）, meningovascular dilatation and congestion（Model group -2）；Chinese medicine group, Amlodipine group, Candesartan
The rarely seen meningovascular dilatation and congestion of group.Be divided into according to congested, extent of hemorrhage have no obvious pathologic change, it is light, in, again, pole
Weigh, respectively mark 0,1,2,3,4.As shown in accompanying drawing 7b, Chinese medicine group significantly reduces meningovascular dilatation and congestion degree, and significantly excellent
In Amlodipine, Candesartan（p<0.05）.
On the basis of the present invention is based on early stage observation, prehypertensive patient is intervened to clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription and entered
Row research, result of study is disclosed, and clearing liver kidney-nourishing wind-dispelling Chinese medicine compound prescription not only significantly reduces prehypertensive patient systolic pressure, diastole
Voltage levels, and significantly reduce prehypertensive patient's systolic pressure load.And the present invention is disclosed in animal experiment study, clear liver
Kidney-nourishing wind-dispelling Chinese medicine compound prescription early intervention can significantly reduce SHR rats systolic pressure, diastolic pressure level, delay SHR rat blood pressures
It is lasting to rise, and there is significant protective effect to the caused by hypertension heart, brain, kidney target organ damage.This research is taken off first
Show the clearing liver significant antihypertensive effect of kidney-nourishing wind-dispelling Chinese medicine compound prescription and its protective effect damaged to target organs of patients with essential hypertension, be hypertension
Preventing and treating and provide brand-new thinking to the protective effect that target organs of patients with essential hypertension is damaged.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (5)
1. a kind of prevent and treat hypertension, the Chinese medicine composition of protection target organs of patients with essential hypertension infringement, it is characterised in that described Chinese medicine group
Compound is made up of the bulk drug of following parts by weight：It is 10-20 parts of Ligusticum wallichii, 10-20 parts of radix bupleuri, 3-9 parts of the coptis, 10-20 parts of notopterygium root, anti-
10-20 parts of wind, 20-40 parts of selfheal, 10-20 parts of radix cyathulae, 10-20 parts of sealwort, 15-25 parts of the shell of seaear, stir-baked RADIX SCUTELLARIAE 10-20
Part, 10-20 parts of Ramulus Taxilli.
2. Chinese medicine composition according to claim 1, it is characterised in that described Chinese medicine composition is by following parts by weight
Bulk drug is made：13-17 parts of Ligusticum wallichii, 13-17 parts of radix bupleuri, 5-7 parts of the coptis, 13-17 parts of notopterygium root, windproof 13-17 parts, selfheal
27-33 parts, 13-17 parts of radix cyathulae, 13-17 parts of sealwort, 17-23 parts of the shell of seaear, 13-17 parts of stir-baked RADIX SCUTELLARIAE, 13-17 parts of Ramulus Taxilli.
3. Chinese medicine composition according to claim 1, it is characterised in that described Chinese medicine composition is by following parts by weight
Bulk drug is made：15 parts of Ligusticum wallichii, 15 parts of radix bupleuri, 6 parts of the coptis, 15 parts of notopterygium root, windproof 15 parts, 30 parts of selfheal, 15 parts of radix cyathulae,
15 parts of sealwort, 20 parts of the shell of seaear, 15 parts of stir-baked RADIX SCUTELLARIAE, 15 parts of Ramulus Taxilli.
4. according to application of any described Chinese medicine compositions of claim 1-3 in the medicine of preventing hypertension is prepared.
5. according to any described Chinese medicine compositions of claim 1-3 in the medicine that protection target organs of patients with essential hypertension is damaged is prepared
Using.
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| CN101306129A (en) * | 2007-05-14 | 2008-11-19 | 上海中医药大学附属龙华医院 | Chinese herbal medicine compound preparation for treating hypertension and its preparation method |
| CN101987130A (en) * | 2009-07-31 | 2011-03-23 | 上海中医药大学附属普陀医院 | Traditional Chinese medicine compound preparation for treating early hypertension kidney damage |
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| CN101306129A (en) * | 2007-05-14 | 2008-11-19 | 上海中医药大学附属龙华医院 | Chinese herbal medicine compound preparation for treating hypertension and its preparation method |
| CN101987130A (en) * | 2009-07-31 | 2011-03-23 | 上海中医药大学附属普陀医院 | Traditional Chinese medicine compound preparation for treating early hypertension kidney damage |
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