CN106334685A - Automatic cleaning system for biological chips - Google Patents

Abstract

The invention provides an automatic cleaning system for biological chips. The automatic cleaning system for biological chips comprises a workbench, a two-dimensional lifting mechanical arm arranged on the workbench, and a plurality of unit servo motors which are connected to the workbench. The automatic cleaning system for biological chips further comprises an incubation reaction unit, an immersion cleaning unit, a flushing unit and an aftertreatment unit, wherein the incubation reaction unit, the immersion cleaning unit, the flushing unit and the aftertreatment unit are all arranged on the workbench. A first turnplate, a second turnplate, a third turnplate and a fourth turnplate are driven to rotate by the unit servo motors correspondingly. The first turnplate and the second turnplate are further connected with chip shaking devices. The automatic cleaning system for biological chips is perfect in structure and convenient to use, an automatic cleaning line which is efficient and convenient and fast to use is formed, the working efficiency is greatly improved, the labor intensity of workers is greatly relieved, and the cleaning effect is excellent.

Description

A kind of biochip automated cleaning system

Technical field

The present invention relates to biochip technology field, specifically a kind of biochip automated cleaning system.

Background technology

Biochip, also known as protein chip or gene chip, they originate from dna hybridisation probe technique and semi-conductor industry The crystallization that technology combines.This technology mean by a large amount of probe molecules be fixed on holder after with carry fluorescently-labeled dna or Other sample molecules are hybridized, by detecting the hybridization signal intensities of each probe molecule and then obtaining the quantity of sample molecule And sequence information.Biochip adopts transparent material injection to be formed at present, and upper and lower two dice pressing buckles, by layer of glass fiber Film is fixed on centre, and in biochemical reaction and processing procedure, biochip needs multiple through incubation reaction, cleaning, fractionation etc. Processing step, and in traditional operation in those steps, it is required to substantial amounts of manually operation, pretend the concordance of industry Difference, and the labor intensity of workman is very big, and general work efficiency is not also high, and input cost can be very big in the long run, with output It is not directly proportional.

Content of the invention

The technical purpose of the present invention is to provide a kind of biochip automated cleaning system, solves traditional operation automatization The problem that low degree, inefficiency, labor strength are big, input cost is high.

The concrete technical scheme of the present invention is as follows: a kind of biochip automated cleaning system, including workbench, located at institute State the lifting two-dimentional machinery arm on workbench and be connected to multiple unit servomotors of described workbench, also include common located at Incubation reaction unit on described workbench, embathe unit, rinse unit and post-processing unit；Described incubation reaction unit includes First rotating disk, house for the chip Container of biochip and being used for being fixed on described first rotating disk fixing described chip First fixed stop of device；The described unit that embathes includes the second rotating disk, is used for putting into and embathes life on described second rotating disk The chip rinsing container of thing chip, for fixing the second fixed stop of described chip rinsing container and located at described workbench For opening or closing the headstock gear of chip rinsing container；Described flushing unit includes the 3rd rotating disk, located at described 3rd turn It is used on disk fixing the 3rd fixed stop of biochip, for rinsing the flushing framework of biochip and being used for installing described punching Wash framework and the vertical reciprocating mechanism with described 3rd rotating disk cooperation；Described post-processing unit include the 4th rotating disk, located at For fixing the 4th fixed block plate of described chip Container on described 4th rotating disk, being used on described workbench will be described Chip Container base segregation apparatuss detached with biochip and on described workbench be used for will place an order on biochip The detached chip detachment apparatus of first piece；Described chip Container includes accommodating base, the edge gear on described accommodating base Wall and the biochip sticking department on described edge retaining wall, described accommodating base are formed and are surrounded by described edge retaining wall Biochip accommodation space；Described biochip sticking department includes locking seat on described edge retaining wall, located at described lock Moving horizontally space and moving horizontally movable block spatially described in being placed in reservation；Described movable block is provided with mobile reset Torsion spring, described locking seat is provided with the fluting positioned at described mobile reduction torsion spring both sides, and the two ends of described mobile reduction torsion spring are divided It is not provided with the extension inserted in two described flutings；Described movable block tail end is also associated with shank of the key, and described shank of the key end is provided with Lock nut, the described space that moves horizontally is through to outside described locking seat, and described shank of the key stretches out described locking seat；Described first turn Unit servomotor described in one drives rotation respectively for disk, described second rotating disk, described 3rd rotating disk, described 4th rotating disk；Institute State the first rotating disk, described second rotating disk is also associated with chip shaking device.

Preferably, described chip rinsing container include box body, the box mouth located at described box body top, located at described box body The upper connection shaft seat being located at described box mouth side and the lid being connected to described connection shaft seat, described lid is provided with moving block, Described moving block is provided with the rotating shaft being connected with described connection shaft seat, and described rotating shaft is provided with rotation reduction torsion spring, described rotation Reduction torsion spring is provided with two end extensions inserting described moving block, described connection shaft seat respectively；Described chip embathes appearance Device also includes being located at the cover lock portion of described box mouth opposite side on described box body and the cleaning on described box body is used Hole group, described connection shaft seat and described cover lock portion are mutually in the offside on described box body；Described cleaning hole group includes Washing liquid hand-hole, washing liquid tap and tray interior air pressure tap；Described cover lock portion includes being connected to described box body Locking pedestal, located at described locking pedestal on horizontal sliding space and the sliding shoe being placed on described horizontal sliding space； It is additionally provided with lock, described lock is locked with described sliding shoe cooperation on described lid.Described cover lock portion is also included located at institute State locking pedestal on be inserted vertically into space, described horizontal sliding space with described be inserted vertically into space intersection converge, described slip Build end be located at described be inserted vertically in space, described lock can insert described in be inserted vertically in space and described lock be provided with For the latch hooking with described sliding shoe head end bottom surface；Described sliding shoe is provided with slip reduction torsion spring, described locking pedestal It is provided with the side fluting positioned at slip reduction torsion spring both sides, being respectively arranged at two ends with of described slip reduction torsion spring is inserted described in two Extension in the fluting of side；Described sliding shoe front end is provided with the inclined plane for pushing force for described lock；Described sliding shoe Tail end is also associated with pull handle, and described pull handle end is provided with draws cap, and described horizontal sliding space is through to outside described locking pedestal, Described pull handle stretches out described locking pedestal.

Preferably, described headstock gear includes support body, described support body is provided with left plate and right plate, described left plate It is provided with the cap-opening mechanism for opening cleaning container lid, described right plate is provided with the conjunction for closing cleaning container lid Lid mechanism；Described cap-opening mechanism includes uncapping with servomotor, be connected to described in uncap with servomotor uncap with shaft coupling, Uncap described in being connected to the uncapping with screw mandrel of shaft coupling, be connected to described in uncap and connected with walking seat and one end with uncapping of screw mandrel Uncap with walking seat and the other end is connected with the uncapping with walking frame of lock remover in described；Described lock remover include unlocking framework and located at Hollow aisle in described unlocking framework, the side block wall of the side of close described right plate of described unlocking framework is provided with and institute State the pull handle Ka Dao that hollow aisle communicates, this side block wall is divided into upside retaining wall and downside retaining wall by described pull handle Ka Dao；Described Upside retaining wall and/or described downside retaining wall inner surface from one end to the other end gradually in described unlocking framework with this side block wall Relative opposite side retaining wall tilts；Described closing mechanism includes closing lid servomotor, is connected to described closing lid servomotor Closing lid shaft coupling, be connected to the closing lid screw mandrel of described closing lid shaft coupling, be connected to the closing lid of described closing lid screw mandrel With walking seat and one end is connected to described closing lid with walking seat and the other end is connected with the closing lid of gland device with walking frame；Described gland device bag Include and be connected to described closing lid with walking the installing rack of frame and the pinch roller on described installing rack.

Preferably, being connected with Rotational Cylindrical below described 3rd rotating disk, be provided with inside described Rotational Cylindrical rolling bearing and with The central shaft of described rolling bearing cooperation；Described vertical reciprocating mechanism includes sequentially passing through described central shaft and the described 3rd The vertical guide rod of rotating disk and be used for making described vertical guide rod carry out vertically reciprocating vertical guide-bar driving mechanism；Described flushing Framework includes the first framework and the second framework being connected to described vertical guide rod, and described first framework is provided with first jet, institute State the second framework and be provided with second nozzle.

Preferably, described vertical guide-bar driving mechanism includes vertical guide rod motor, is connected to and described vertically leads The vertical guide rod shaft coupling of bar motor, the vertical guide rod screw mandrel being connected to described vertical guide rod shaft coupling, company The Mobile base being connected to described vertical guide rod screw mandrel and the fixed plate being connected to described Mobile base, described vertical lower end of the guide rod connects It is provided with the linear bearing coordinating with described vertical guide rod in described fixed plate, described central shaft；Described first framework is included even It is connected to the base on top and the erecting bed on described base that described vertical guide rod is piercing in described 3rd rotating disk, described One nozzle is on described erecting bed；Described second framework includes being connected to described vertical guide rod and is piercing in described 3rd rotating disk The support shaft on top, it is connected to the top board of described support shaft, is connected to the column of described top board and is connected between described column Installation band, described second nozzle located at described install band on, described installation band be suspended in above described 3rd rotating disk.

Preferably, described base segregation apparatuss include base separation framework, described base separation framework includes two pieces of bottoms The base of seat separating side plate and two pieces of described base separating side plates of connection separates back plate, described base separating side plate and described base Separate back plate and be collectively forming base separation longitudinal space, described base separation longitudinal space includes upper base lead-in cavity and bottom Base reclaims chamber；Base guide bar is connected with described base separation back plate, described base separating side plate be provided with described on The base support that the base guiding channel being interlinked to the outside in portion's base lead-in cavity is coordinated with described base guiding channel draw section and with described The biochip clamp system of base guiding channel cooperating and base unlocking mechanism, described guide bar is provided with guiding and slides Seat, described guiding slide is connected with installing arm, and described installing arm is provided with base mechanical gripper and for described biology core The clutch of piece clamp system force.

Preferably, described biochip clamp system includes axle bed in described base separating side plate, inserts institute State in axle bed and passed through the movable axis of described base separating side plate, be articulated with described movable axis by described upper base lead-in cavity The active lever of the one end outside described base separating side plate, the biochip push rod being connected to described active lever and fixation It is connected to described base separating side plate and be articulated with the support shaft in the middle part of described active lever；Described biochip push rod passes through institute State base guiding channel；Described base guiding channel is provided with baffle plate, and described biochip push rod passes through described baffle plate, described life The reset spring being offseted with described baffle plate is arranged with thing chip push rod；Described clutch includes being fixedly connected on described installation Pushing tow main body on arm and being used for described movable axis from described upper base lead-in cavity to described in described pushing tow main body The extrapolated pushing tow face of base separating side plate；Described base unlocking mechanism includes being fixedly connected on the solution of described base separating side plate Lock framework and the hollow aisle in described unblock framework, described unblock framework is near described upper base lead-in cavity side Side wall is provided with the shank of the key Ka Dao communicating with described hollow aisle, and this side wall is divided into upper side wall and downside by described shank of the key Ka Dao Wall；The inner surface of described upper side wall and/or described lower wall is by away from the extremely close described base in described base separation back plate one end Separate back plate one end gradually to tilt to hollow aisle；Described upper side wall is additionally provided with the close described base with respect to described lower wall Separate the extension of back plate side；Described base support draw section include located at described base separating side plate inner surface respectively be located at institute State epimere and the hypomere of the upper and lower both sides of base guiding channel；Described epimere is provided with the close described base with respect to described hypomere Separate back plate side lengthening section, described lengthening section be provided with base squeeze cut somebody's hair；Described installing arm is externally connected with haulage gear, institute State haulage gear to include power for traction machine, the traction shaft coupling being connected to described power for traction machine, be connected to described traction use The traction screw mandrel of shaft coupling, be connected to the connecting seat of described traction screw mandrel and one be connected to described connecting seat and other end It is connected to the transmission bridge of described installing arm.

Preferably, described chip detachment apparatus include transmission motor, are connected to the driving tooth of described transmission motor Take turns, be used for the driven gear with described driving gear synchronous axial system and the transmission being connected described driving gear and described driven gear Band；Described chip detachment apparatus also include chip separator frame, grab for biochip is sent into the first of described chip separator frame Take mechanism and coordinate described first grasping mechanism to be used for clamping the second grasping mechanism of dice on biochip and for giving birth to The detached detachment means of the upper and lower dice of thing chip, described detachment means and described first grasping mechanism are commonly connected to described biography Dynamic band；Described chip separator frame include two chips separating side plate and connect two pieces of described chip separating side plates chip separate after Plate, described chip separation back plate together form chip with described chip separating side plate and separates longitudinal space, and described chip separates Longitudinal space includes the upper core for described first grasping mechanism, described second grasping mechanism and described detachment means cooperating Piece lead-in cavity and the lower chips recovery chamber for housing dice on biochip.

Preferably, described detachment means include being connected to the drive link of described transmission belt, are connected to described drive link Connecting rod, the first transmission group being driven by described drive link and the second transmission group being driven by described first transmission group；Described company Extension bar is provided with driving cog；The first axle bed that described first transmission group includes being respectively arranged in two described chip separating side plates, Insert two described first axle beds and pass through the first rotating shaft of described upper chip lead-in cavity and be connected to described first rotating shaft two The first gear at end, one of described first gear is connected with the engagement of described driving cog；Described second transmission group is included respectively The second axle bed in two described chip separating side plates, it is respectively implanted two described second axle beds and stretches into described upper core Second rotating shaft of piece lead-in cavity, it is connected to described second rotating shaft and is located at the chip sled block that described upper chip guides one end of intracavity With the second gear being connected to the described second rotating shaft other end, the engagement of described second gear and described first gear is connected；Described It is additionally provided with second rotating shaft positioned at the rotating shaft back-moving spring between described second axle bed and described second gear；Described first crawl Mechanism includes chip mechanical gripper, the linking arm being connected to described chip mechanical gripper and the transmission for driving described linking arm Arm, described transmission arm is simultaneously coupled to described transmission belt；Described second grasping mechanism is included in described chip separation back plate Pedestal, be connected to the pull bar of described pedestal, be articulated with the described chip separating side plate of two pieces of deflection respectively of described pull bar head end Two poles and be hingedly connected to the two chips clamping plate of two described poles；Described chip clamping plate slidably connects jointly leads Bar, described guide rod two ends are fixedly connected on described chip separating side plate, described guide rod is arranged with positioned at described chip clamping plate it Between clamping plate back-moving spring.

Preferably, described chip shaking device includes chassis and telophragma, described chassis is connected to described unit servo Motor and driven by described unit servomotor, described telophragma is located at described chassis and described first rotating disk/described second turn Between disk, be provided between described chassis and described telophragma multiple for support the first connectors, described telophragma with described Be provided between first rotating disk/described second rotating disk multiple for supporting and making that described first rotating disk/described second rotating disk is eccentric to be turned The second dynamic connector, one of described second connector is connected with lead agency；Described first connector includes being connected to The upper pedestal of described telophragma, it is connected to the lower base on described chassis and is connected between described upper pedestal and described lower base Breeze way；Described second connector includes being fixedly connected on the upper axle bed of described first rotating disk/described second rotating disk, is fixedly connected Be rotationally connected with described upper axle bed and the rotor of described lower axle bed in the lower axle bed of described telophragma with simultaneously；Described rotor Rotate the upper connecting shaft being connected including main body block, located at described main body block upper surface with described upper axle bed and located at described main body Block lower surface and rotate, with described lower axle bed, the lower connecting shaft being connected, the axial line of described upper connecting shaft and described lower connecting shaft Axial line is not on the same line；Described lead agency includes drive motor and described drive motor on described chassis The belt pulley being in transmission connection and the wheel shaft being connected with described belt pulley, described wheel shaft is solid with the lower connecting shaft of described second connector Surely connect or be integrally formed.

The technological merit of the present invention is described biochip automated cleaning system structure improvement, easy to use, formation Article one, efficiently, easily line cleans in automatization, and work efficiency is greatly improved, and significantly reduces labor strength, cleaning effect Really excellent.

Brief description

Fig. 1 is the overall structure diagram of the embodiment of the present invention；

Fig. 2 is the structural representation of described chip Container；

Fig. 3 is the structural representation of β in Fig. 2；

Fig. 4 is the structural representation of described chip shaking device；

Fig. 5 is the partial structural diagram of described chip shaking device；

Fig. 6 is the positive structure schematic of described chip rinsing container；

Fig. 7 is the structure schematic diagram of described chip rinsing container；

Fig. 8 is the partial structural diagram of described box body；

Fig. 9 is the structural representation of α part in Fig. 6；

Figure 10 is a side-looking viewing angle constructions schematic diagram of described headstock gear；

Figure 11 is that the opposite side of described headstock gear regards viewing angle constructions schematic diagram；

Figure 12 is the partial structural diagram of described headstock gear；

Figure 13 is the cross-sectional view of described chip flusher；

Figure 14 is the structural representation at a side-looking visual angle of described base segregation apparatuss；

Figure 15 is the partial structural diagram of described base segregation apparatuss；

Figure 16 is the partial structural diagram of described base segregation apparatuss；

Figure 17 is a side-looking viewing angle constructions schematic diagram of described chip detachment apparatus；

Figure 18 is that the opposite side of described chip detachment apparatus regards viewing angle constructions schematic diagram；

Figure 19 is portion's partial structural diagram of described chip detachment apparatus；

In figure is numbered corresponding each toponym and is respectively as follows: a10- first rotating disk, a101- first fixed stop, and b30- chip divides From frame, b301- chip separating side plate, b3011- slideway, the upper position block of b3012-, position block under b3013-, b3014- is multiple Position bar, b3015- back-moving spring, b3016- slideway, b302- chip separation back plate, b303- chip separation header board, b304- connects Bar, b3041- drive link, b30411- driving cog, b3042- first axle bed, b3043- first rotating shaft, b3044- first gear, B3045- second axle bed, b3046- second rotating shaft, b3047- chip prizes block, b3048- second gear, b305- chip mechanical gripping Handss, b3051- linking arm, b3052- transmission arm, b3053- substrate, b3054- substrate, b3055- positive stop, b306- pedestal, B3061- pull bar, b3062- pole, b3063- chip clamping plate, b3064- guide rod, b3065- spring, b307- upper half guides cell body, The upper reset baffle block of b3071-, b308- lower half guides cell body, reset baffle block under b3081-；B10- the 4th rotating disk, b10- the 4th is fixing Block, b20- base separation framework, b201- base separating side plate, b2011- base guiding channel, b2012- axle bed, b2013- Movable axis, b2014- active lever, b2015- biochip push rod, b2016- support shaft, b2017- unlocks framework, b20171- Hollow aisle, b20172- base shank of the key Ka Dao, b20173- upper side wall, b20174- lower wall, b2018- base support draws section, B20181- epimere, b20182- hypomere, b20183- base squeezes and cuts somebody's hair, b202- base separation back plate, before b203- base separates Plate, b204- base guide bar, b2041- installing arm, b2042- base mechanical gripper, b2043- pushing tow main body, b2044- pushing tow Face, b2045- guides slide, b205- power for traction machine, b2051- traction screw mandrel, b2052- traction connecting seat, b2053- Transmission bridge；C10- the 3rd rotating disk, c101- the 3rd fixed stop, the vertical guide channel of c1011- biochip, c102- osculum, C20- rotary unit, c201- Rotational Cylindrical, c202- rolling bearing, c203- central shaft, c207- ring flange, c30- vertically back and forth transports Moving cell, c301- vertical guide rod motor, c302- vertical guide rod shaft coupling, c303- vertical guide rod screw mandrel, C304- fixed plate, the vertical guide rod of c305-, c306- Mobile base, c40- flushing unit, c401- base, c402- erecting bed, C403- support shaft, c404- top board, c405- column, c406- installs band, c407- first jet, c408- second nozzle, c50- Supporting platen；D10- second rotating disk, d101- second fixed stop, d20- support body, d201- left plate, d202- right plate, D203- uncaps and uses servomotor, and d2031- uncaps and uses shaft coupling, and d2032- uncaps and uses screw mandrel, and d2033- uncaps with walking seat, D2034- uncaps with walking frame, d2035- unlocking framework, the hollow aisle of d20351-, and d20352- pull handle Ka Dao, on the upside of d20353- Wall, d20354- lower wall, d204- closing lid servomotor, d2041- closing lid shaft coupling, d2042- closing lid screw mandrel, With walking seat, with walking frame, d2045- installing rack, d2046- pinch roller, d2047- tilts installing plate to d2044- closing lid to d2043- closing lid, D2048- side pushing block, d2049- pushes the ball side face；B1- houses base, b11- putting groove, b2- edge retaining wall, b21- locking seat, B211- slots, b212- spacing preiection, b22- movable block, b221- mast, and b222- biochip compresses end block, and b223- is biological Chip accepts inclined plane, and b23- moves reduction torsion spring, and b24- moves limited block, and b3- biochip seals heelpiece, b4- elasticity Support body, b5- metallic gasket；D1- box body, d11- biochip importing holder, d12- rotary spacing block, d13- washing liquid hand-hole, D14- washing liquid tap, d15- tray interior air pressure tap, d2- lid, d21- moving block, d211- rotating shaft, d22- latches, D221- latch, d23- sealing ring, d24- biochip compact heap, d3- connection shaft seat, d4- locks pedestal, slots in d41- side, D5- sliding shoe, d51- slip reduction torsion spring, d52- cylinder, d53- slip limited block, d54- inclined plane；E1- chassis, in the middle of e2- Disk, e3- first connector, e31- upper pedestal, e32- lower base, e33- breeze way, e4- second connector, the upper axle bed of e41-, Axle bed under e42-, e43- main body block, the upper connecting shaft of e431-, connecting shaft under e432-, e44- centrifugal-block, e5- drive motor, e51- Belt pulley, e52- wheel shaft.

Specific embodiment

Below in conjunction with accompanying drawing, by specific embodiment, the invention will be further described: sees Fig. 1, a kind of biochip Automated cleaning system, including workbench, located at worktable lifting two-dimentional machinery arm be connected to multiple units of workbench and watch Take motor, the incubation reaction unit that also includes jointly on workbench, embathe unit, rinse unit and post-processing unit；Temperature Educate reaction member and include the first rotating disk a10, for fixing the chip Container of biochip and being used on the first rotating disk a10 First fixed stop a101 of fixed chip Container；Embathe unit to include the second rotating disk d10, use on the second rotating disk d10 In putting into and embathe the chip rinsing container of biochip, for the second fixed stop d101 of fixed chip rinsing container with set It is used for opening or closing the headstock gear of chip rinsing container on workbench；Rinse unit and include the 3rd rotating disk c10, located at the On three rotating disk c10 be used for fix biochip the 3rd fixed stop c101, for rinse biochip flushing framework c40 and Rinse framework c40 and the vertical reciprocating mechanism c30 with the 3rd rotating disk c10 cooperation for installing；Post-processing unit includes Four rotating disk b10, on the 4th rotating disk b10 be used for fixed chip Container the 4th fixed block plate b101, located at workbench For be used for biochip is upper and lower by detached with biochip for chip Container base segregation apparatuss with workbench The detached chip detachment apparatus of dice；First fixed stop a101, the second fixed stop d101, the 3rd fixed stop c101, 4th fixed stop b101 each can arrange multiple, each self-forming fixed space, and each block can arrange the post of adjustment dynamics Plug, is used for holding out against chip Container or chip rinsing container or biochip, plays the effect being equivalent to fixture.

See Fig. 2, Fig. 3, chip Container include accommodating base b1, the edge retaining wall b2 on accommodating base b1 and located at Biochip sticking department on edge retaining wall b2, accommodating base b1 is formed and houses sky by the biochip that edge retaining wall b2 surrounds Between, it is provided with biochip sealing heelpiece b3 in biochip accommodation space；Biochip sticking department is included located at edge retaining wall b2 On locking seat b21, moving horizontally space and being placed in the movable block b22 moving horizontally spatially in locking seat b21；Move Motion block b22 is provided with mobile reduction torsion spring b23, and locking seat b21 is provided with the fluting positioned at mobile reduction torsion spring b23 both sides B211, mobile reduction torsion spring b23 are respectively arranged at two ends with the extension inserted in two fluting b211.Movable block b22 is provided with For the mast b221 being fixed by socket for mobile reduction torsion spring b23, mast b221 can also be arranged and prevent mobile reduction torsion spring The cap body of b23 abjection.The inwall of fluting b211 is provided with relative spacing preiection b212, is formed for prolonging between spacing preiection b212 The passageway that long section is inserted.Movable block b22 front end is provided with biochip compression end block b222, and the biochip that can put into is pressed in life On thing chip sealing heelpiece b3.Biochip compression end block b222 top is provided with biochip and accepts inclined plane b223, Neng Goujie Live towards biochip accommodation space decentralization biochip, simultaneously because the design on its inclined-plane receives will be outside for movable block b22 The thrust of the horizontal direction released, outwards pushes movable block b22 open with this, and movable block b22 passes through mobile reduction torsion spring b23 and resets Afterwards biochip is firmly fixed.Movable block b22 tail end is also associated with shank of the key, and shank of the key end is provided with lock nut, moves horizontally Space is through to outside locking seat b21, and shank of the key stretches out locking seat b21.Movable block b22 tail end also can connect mobile limited block b24, Shank of the key, also cross mobile limited block b24, moves horizontally space and is through to outside locking seat b21, mobile limited block b24 position all the time Outside and can offset with locking seat b21 outer surface in locking seat b21, thus limiting the ultimate range that movable block b22 moves inward, Excessive interpolation is avoided to produce problem.

First rotating disk a10, the second rotating disk d10, the 3rd rotating disk c10, the 4th rotating disk b10 are driven by unit servomotor respectively Rotate；First rotating disk a10, the second rotating disk d10 are also associated with chip shaking device.Incubation reaction needs biochip in regulation temperature Carry out internal biochemical reaction under degree, need standing and rock two states and cooperate, and cleaning afterwards be also required to rock with Biochip is allowed fully to be cleaned in cleaning container.

See Fig. 4, Fig. 5, chip shaking device includes chassis e1 and telophragma e2, chassis e1 be connected to unit servomotor and Driven by unit servomotor, telophragma e2 be located between chassis e1 and first rotating disk a10/ the second rotating disk d10, chassis e1 with Be provided between intercalated disc e2 multiple for support the first connector e3, telophragma e2 and first rotating disk a10/ the second rotating disk d10 it Between be provided with multiple the second connector e4 for supporting and making first rotating disk a10/ the second rotating disk d10 eccentric rotary, one of Second connector e4 is connected with lead agency, and chassis e1 is connected to unit servomotor and is driven by unit servomotor；First Connector e3 includes being connected to the upper pedestal e31 of telophragma e2, is connected to the lower base e32 of chassis e1 and is connected to upper pedestal Breeze way e33 between e31 and lower base e32, breeze way may be selected rubber, plastic or other material；Second connector e4 includes solid Surely the upper axle bed e41 being connected to first rotating disk a10/ the second rotating disk d10, the lower axle bed e42 being fixedly connected on telophragma e2 and with When be rotationally connected with axle bed e41 and the rotor of lower axle bed e42；Rotor includes main body block e43, in main body block e43 Surface and rotate upper connecting shaft e431 that is connected and located at main body block e43 lower surface and lower axle bed e42 rotation with upper axle bed e41 Lower connecting shaft e432 connecting, the axial line of the axial line of upper connecting shaft e431 and lower connecting shaft e432 not on the same line, Main body block e43 can be a cylinder；Lead agency includes drive motor e5 and drive motor e5 transmission company on the e1 of chassis The belt pulley e51 the connecing and wheel shaft e52 being connected with belt pulley e51, lower connecting shaft e432 of wheel shaft e52 and the second connector e4 is solid Surely connect or be integrally formed.Centrifugal-block e44, the center of gravity of centrifugal-block e44 and the center of gravity of main body block e43 are additionally provided with main body block e43 Mutually misaligned.Centrifugal-block e44 actual it can also be provided that bigger main body block e43 of volume.Accompanying drawing middle belt pulley e51 and band galvanic electricity The belt connecting of machine e5 omits and is not drawn into.

In real work, servomotor drives first rotating disk a10/ the second rotating disk d10, telophragma e2, chassis e1 to be formed Integral-rotation, drive motor e5 drives the wherein second connector e3 action, and remaining second connector e3 is driven, on rotor Eccentric structure goes up connecting shaft e431, lower connecting shaft e432 makes first rotating disk a10/ the second rotating disk d10 same in the horizontal direction When make a certain amplitude swing so that the placement thing on first rotating disk a10/ the second rotating disk d10 is waved, simulation Artificial rocking action.The presence of centrifugal-block e44 can make rotor entirely can there is a centrifugal force in rotation process, to people Higher for the simulation degree of rocking action, centrifugal-block e44 generally only need to arrange one.

See Fig. 6, Fig. 7, Fig. 8, Fig. 9, chip rinsing container include box body d1, the box mouth located at box body d1 top, located at box The connection shaft seat d3 of box mouth side is located on body d1 and is connected to the lid d2 of connection shaft seat d3, lid d2 is provided with moving block D21, moving block d21 are provided with the rotating shaft d211 being connected with connection shaft seat d3, and rotating shaft d211 is provided with rotation reduction torsion spring, rotate Reduction torsion spring is provided with insertion moving block d21, two end extensions of connection shaft seat d3 respectively, and rotating reduction torsion spring can make lid Body d2 automatic stabilisation when not covering remains on, simultaneously box body d1 be provided with for moving block d21 cooperation and with this Limit the rotary spacing block d12 that lid d2 maximum opens radius；The sealing ring d23 being mated with box mouth is additionally provided with lid d2, protects The cleaning sealing of card box body d1；Biochip compact heap d24 is additionally provided with lid d2；It is additionally provided with life in box body d1 internal side wall Thing chip imports holder d11, is capable of the position of the fixing biochip of auxiliary reception, and biochip imports holder d11 and includes holder Body and the jig arm located at clipping base two ends, are provided with biochip and import space between jig arm.Chip rinsing container also include located at The cover lock portion of box mouth opposite side and the hole group of the cleaning on box body d1, connection shaft seat d3 and lid are located on box body d1 Sticking department is mutually in the offside on box body d1；Cleaning hole group includes washing liquid hand-hole d13, washing liquid tap d14 and box Body air pressure inside tap d15, can the existing apparatus such as external flow pump, flexible pipe, negative pressure pump.Cover lock portion includes being connected to box The locking pedestal d4 of body d1, the horizontal sliding space on locking pedestal d4 and the sliding shoe being placed on horizontal sliding space d5；Lock d22, lock d22 and sliding shoe d5 cooperation locking are additionally provided with lid d2.Cover lock portion is also included located at locking base Seat d4 on be inserted vertically into space, be inserted vertically into space may be selected longitudinally through locking pedestal d4, be easy to the lock on lid d2 D22 is accessible to insert.Horizontal sliding space converges with being inserted vertically into space intersection, and sliding shoe d5 head end is located at and is inserted vertically into space In, lock d22 can insert and be inserted vertically in space and latch d22 and be provided with the latch for hooking with sliding shoe d5 head end bottom surface d221；Lock d22 inserts when being inserted vertically into space, and sliding shoe d5 is in normal static condition and sliding shoe d5 head end gear is in lock On the placing direction of button d22, now sliding shoe d5 is pulled out, step down to lock d22, lock d22 continues to put completely simultaneously Enter to be inserted vertically in space, then sliding shoe d5 is back pushed and the bottom surface of sliding shoe d5 and the latch d221 phase latching d22 Support and close, stop lock d22 from exiting.Sliding shoe d5 is provided with slip reduction torsion spring d51, and locking pedestal d4 is provided with multiple positioned at sliding Prolonging in two sides fluting d41 is inserted in being respectively arranged at two ends with of the side fluting d41 of position torsion spring d51 both sides, slip reduction torsion spring d51 Stretch section；Sliding shoe d5 front end is provided with inclined plane d54 for pushing force for lock d22, due to the presence of inclined plane d54, locks Button d22 inserts and can press to inclined plane d54 when being inserted vertically into space, thus sliding shoe d5 is produced horizontal direction component so that Sliding shoe d5 pressurized can exit automatic resigning.Sliding shoe d5 is provided with the cylinder for being fixed by socket for slip reduction torsion spring d51 D52, cylinder d52 can arrange the cap body of anti-sliding stop back-moving spring d51 abjection；Sliding shoe d5 tail end is also associated with pull handle, draws Pommel portion is provided with draws cap, and horizontal sliding space is through to outside locking pedestal d4, and pull handle stretches out locking pedestal d4.Sliding shoe d5 tail End is also associated with slip limited block d53, and also cross slip limited block d53, sliding space is through to outside locking pedestal d4 pull handle Portion, slip limited block d53 is always positioned at locking pedestal d4 outside and can offseting with locking pedestal d4 outer surface, thus limiting slip The ultimate range of block d5 slid inward, it is to avoid excessively interpolation and produce problem.

See Figure 10, Figure 11, Figure 12, headstock gear includes support body d20, support body d20 is provided with left plate d201 and right plate D202, left plate d201 are provided with the cap-opening mechanism for opening cleaning container lid d2, and right plate d202 is provided with for closing Close the closing mechanism of cleaning container lid d2；Cap-opening mechanism includes uncapping with servomotor d203, is connected to and uncaps with servo electricity Machine d203 uncaps with shaft coupling d2031, is connected to uncapping with screw mandrel d2032, being connected to and uncap with shaft coupling d2031 of uncapping With uncapping with walking a d2033 and one end is connected to and uncaps with walking a d2033 and the other end is connected with lock remover of screw mandrel d2032 Uncap with walking frame d2034；Lock remover includes unlocking framework d2035 and the hollow aisle d20351 in unlocking framework d2035, The side block wall of the side of close right plate d202 of unlocking framework d2035 is provided with the pull handle card communicating with hollow aisle d20351 This side block wall is divided into upside retaining wall d20353 and downside retaining wall d20354 by road d20352, pull handle card road d20352；Upper side block The inner surface of wall d20353 and/or downside retaining wall d20354 from one end to the other end gradually in unlocking framework d2035 with this side The relative opposite side retaining wall of retaining wall tilts；Closing mechanism includes closing lid servomotor d204, is connected to closing lid servomotor The closing lid shaft coupling d2041 of d204, be connected to closing lid shaft coupling d2041 closing lid screw mandrel d2042, be connected to closing lid use The closing lid of screw mandrel d2042 is with walking a d2043 and one end is connected to closing lid with walking a d2043 and the other end is connected with the conjunction of gland device Lid is with walking frame d2044；Gland device includes being connected to closing lid with walking the installing rack d2045 of frame d2044 and on installing rack d2045 Pinch roller d2046.Installing rack d2045 is provided with inclination installing plate d2047, and pinch roller d2046 is on inclination installing plate d2047. Side pushing block d2048 for lateral pushing tow cleaning container lid is additionally provided with installing rack d2045.Side pushing block d2048 is provided with side Push the ball face d2049.In some cases, the position of lid d2 inclination opening state is likely difficult to and pinch roller d2046 effective contact, this When side pushing block d2048 can coordinate rotating disk rotate lid d2 is laterally elapsed to appropriate location, so that pinch roller d2046 can be suitable Profit contacts and pushes lid d2.

In real work, cleaning container is fixed on the second rotating disk d10, can stop when going to appropriate location, uncap with watching Take motor d203 to start, finally uncap and can be moved to the second rotating disk d10 with walking frame d2034, drive unlocking framework d2035 synchronously to move Dynamic, the pull handle of cleaning container can snap in pull handle card road d20352 afterwards, pull handle end draw cap can with upside retaining wall d20353, The inner surface laminating of downside retaining wall d20354, the inner surface of upside retaining wall d20353 and/or downside retaining wall d20354 is by one end extremely The other end gradually tilts to opposite side retaining wall relative with this side block wall in unlocking framework d2035, herein " one end is to another End " i.e. by cleaning container direction or the second rotating disk d10 direction to support body d20 direction so that pull handle with pull handle Ka Dao In the relative motion of d20352, cap is drawn gradually to be drawn by the inclined inner surface of upside retaining wall d20353 and/or downside retaining wall d20354 Dynamic, pull handle is drawn out therewith so that sliding shoe d5 is no longer fixed with the lock d22 phase on lid d2, and lid d2 is immediately because rotating Reduction torsion spring and be in open mode；Then, biochip is put in cleaning container, closing lid is started with servomotor d204, Final closing lid can be moved to the second rotating disk d10 direction with walking a d2043, drives installing rack d2045 synchronizing moving, pinch roller d2046 The contact lid d2 back side at a slant, and gradually depress the lid that open d2 until covering.Uncap with walking frame d2034 and conjunction Lid can be made up of the connection of multiple connecting rods with walking frame d2044.

See that Figure 13, the 3rd fixed stop c101 are arranged to vertical block in pairs, between the 3rd fixed stop c101 Form biochip placement space, the 3rd fixed stop c101 is provided with biochip vertical guide channel c1011, in order to giving birth to Thing chip is accurately stably inserted, and biochip is placed between two the 3rd fixed stop c101 by card；Below 3rd rotating disk c10 It is connected with Rotational Cylindrical c201, inside Rotational Cylindrical c201, be provided with rolling bearing c202 and the central shaft with rolling bearing c202 cooperation C203, is connected with ring flange c207, ring flange c207 and servomotor c205 all located at supporting platen c50 below central shaft c203 On, the rolling bearing c202 outside central shaft c203 can adopt angular contact bearing；Vertically reciprocating mechanism c30 is included successively Through the vertical guide rod c305 of central shaft c203 and the 3rd rotating disk c10 be used for making vertical guide rod c305 vertically be moved back and forth Vertical guide-bar driving mechanism；Rinse framework c40 and include the first framework and the second framework that are connected to vertical guide rod c305, first Framework is provided with first jet c407, and the second framework is provided with second nozzle c408.Vertically guide-bar driving mechanism includes vertically leading Bar motor c301, be connected to vertical guide rod motor c301 vertical guide rod shaft coupling c302, be connected to perpendicular The vertical guide rod screw mandrel c303 of straight guide rod shaft coupling c302, be connected to vertical guide rod screw mandrel c303 Mobile base c306 and It is connected to fixed plate c304 of Mobile base c306, vertical guide rod c305 lower end is connected to fixed plate c304, sets in central shaft c203 There is the linear bearing with vertical guide rod c305 cooperation；First framework includes being connected to vertical guide rod c305 and is piercing in the 3rd rotating disk The base c401 on the top of the c10 and erecting bed c402 on base c401, first jet c407 is on erecting bed c402； Second framework includes being connected to vertical guide rod c305 and is piercing in support shaft c403 on top of the 3rd rotating disk c10, is connected to support The top board c404 of axle c403, the column c405 being connected to top board c404 and the installation band c406 being connected between column c405, the Two nozzle c408, located at installing on band c406, install band c406 and are suspended in above the 3rd rotating disk c10.First jet c407 and second Nozzle c408 can external delivery hose.It is additionally provided with osculum c102 on 3rd rotating disk c10.Vertically guide rod c305 and support shaft Between c403, support shaft c403 and top board c404, between top board c404 and column c405, between column c405 and installation band c406 Each all can mode with bolts to be connected, realize being mutually permanently connected.Unit servomotor and Rotational Cylindrical c201 The 3rd rotating disk c10 is driven to rotate, vertical guide rod is driven vertically with motor c301 and vertical guide rod screw mandrel c303 Guide rod c305 carries out pumping of vertical direction；The vertically vertical motion of guide rod c305 and the rotation of the 3rd rotating disk c10 Motion is separate, is combined by above two motion, each position of biochip can by first jet c407 and Second nozzle c408 is rinsed, and realizes the Omnibearing automatic cleaning to biochip, and rinse unit stopping The effect of the centrifuge dripping to biochip in the case of pre-washing function, is realized using turntable rotation.

See Figure 14, Figure 15, Figure 16, base segregation apparatuss include base separation framework b20, base separation framework b20 includes Two pieces of base separating side plates b201, base separation back plate b202 connecting two pieces of base separating side plates b201 and base separation header board B203, base separating side plate b201 and base separation back plate b202, base separation header board b203 are collectively forming base and separate longitudinally Space, base separation longitudinal space includes upper base lead-in cavity and lower base reclaims chamber；Upper base lead-in cavity and bottom Base is reclaimed chamber and can be defined by base separation header board b203, and base separation header board b203 separates back plate b202 phase with base Right, base separation header board b203 is less than base separation back plate b202, is equivalent to lower base and reclaims chamber by base separation header board B203, base separation back plate b202 and base separating side plate b201 surround, and upper base lead-in cavity is by base separation back plate B202 and base separating side plate b201 surround, upper base lead-in cavity do not have base separation header board b203 stop and with extraneous phase Logical；Base guide bar b204 is connected with base separation back plate b202, base guide bar b204 extends from upper base lead-in cavity To space outerpace, that is, perpendicular to the setting of base separation back plate b202, base separating side plate b201 is provided with base guide bar b204 The base support being coordinated with the base guiding channel b2011 being interlinked to the outside in upper base lead-in cavity and base guiding channel b2011 is drawn Section b2018 and the biochip clamp system with base guiding channel b2011 cooperating and base unlocking mechanism, base guides Bar b204 is provided with guiding slide b2045, guiding slide b2045 is connected with installing arm b2041, installing arm b2041 is provided with Base mechanical gripper b2042 and the clutch for the tight mechanism force to biological chip gripper.Base mechanical gripper b2042 will house Base b1 grabs and delivers to base support and draw on section b2018, enters in upper base lead-in cavity along base guiding channel b2011, linkage Device can drive biochip clamp system to realize holding out against clamping to biochip.Installing arm b2041 is externally connected with haulage gear, Haulage gear includes power for traction machine b205, the traction shaft coupling being connected to power for traction machine b205, is connected to traction connection The traction screw mandrel b2051 of axial organ, be connected to the connecting seat b2052 of traction screw mandrel b2051 and one be connected to connecting seat B2052 and other end are connected to the transmission bridge b2053 of installing arm b2041.

Biochip clamp system includes located at the axle bed b2012 in base separating side plate b201, inserts in axle bed b2012 And by upper base lead-in cavity pass through base separating side plate b201 movable axis b2013, be articulated with movable axis b2013 the bottom of positioned at The active lever b2014 of one end outside seat separating side plate b201, it is connected to the biochip push rod b2015 of active lever b2014 Be fixedly connected on base separating side plate b201 and be articulated with support shaft b2016 in the middle part of active lever b2014；Biochip top Bar b2015 passes through base guiding channel b2011；Base guiding channel b2011 is provided with baffle plate, and biochip push rod b2015 wears Cross baffle plate, biochip push rod b2015 is arranged with the reset spring being offseted with baffle plate；Movable axis b2013, active lever B2014, biochip push rod b2015, support shaft b2016 utilize lever principle, when movable axis b2013 is to action outside side plate, Active lever b2014 stress and do the rotation of certain angle around support shaft b2016, so that biochip push rod b2015 Move to upper base lead-in cavity in company with by base guiding channel b2011, and withstand the biochip being located therein.Support shaft B2016 can be fixed by being fixedly connected on fixed seat, fixed plate of base separating side plate b201 etc..Clutch includes fixing Be connected to pushing tow main body b2043 in installing arm b2041 and be used in pushing tow main body b2043 by movable axis b2013 by Portion's base lead-in cavity is to the extrapolated pushing tow face b2044 of base separating side plate b201；Pushing tow face b2044 conflicts movable axis B2013 one end, movable axis b2013 is pushed out, so that the lever principle of aforementioned biological chip clamp system comes into force.

Base unlocking mechanism includes being fixedly connected on unblock framework b2017 of base separating side plate b201 and located at unblock frame Hollow aisle b20171 in body b2017, unblock the side wall near upper base lead-in cavity side for framework b2017 be provided with The shank of the key card road b20172 that empty aisle b20171 communicates, shank of the key card road b20172 by this side wall be divided into upper side wall b20173 with Side wall b20174；The inner surface of upper side wall b20173 and/or lower wall b20174 is by away from base separation back plate b202 one end extremely Gradually tilt to hollow aisle b20171 near base separation back plate b202 one end；Shank of the key is so made to snap in shank of the key Ka Dao After b20172, due to the presence of upper side wall b20173, the inclined inner surface of lower wall b20174, accommodating base b1 more divides to base Move from back plate b202, shank of the key is just pulled outward, and final shank of the key is thoroughly drawn together with the movable block b22 that press against biochip Go out, do not relock biochip, biochip is clamped by biochip clamp system, accommodating base b1 is then separated.Upper side wall B20173 is additionally provided with the extension of the close base separation back plate b202 side with respect to lower wall b20174；In accommodating base b1 Shank of the key when being eventually pulled completely out, will not be blocked because of lower wall b20174, then can enable entirely to house base b1 smoothly Fall into lower base to reclaim in chamber.Base support is drawn section b2018 and is included being located at respectively located at base separating side plate b201 inner surface The epimere b20181 of the upper and lower both sides of base guiding channel b2011 and hypomere b20182；Epimere b20181 is provided with respect to hypomere The lengthening section of the close base separation back plate b202 side of b20182, lengthening section is provided with base and squeezes the b20183 that cuts somebody's hair；Squeeze and cut somebody's hair B2018 touches accommodating base b1 and it is extruded with force, so that accommodating base b1 is smoothly taken off and falls into lower base and return Receive in chamber.

See Figure 17, Figure 18, Figure 19, chip detachment apparatus include transmission motor, are connected to the driving tooth of transmission motor Take turns, be used for the driven gear with driving gear synchronous axial system and the transmission belt being connected driving gear and driven gear；Chip separates Device also includes chip separator frame b30, the first grasping mechanism and cooperation first for biochip is sent into chip separator frame Grasping mechanism be used for clamping the second grasping mechanism of dice on biochip with for upper and lower for biochip dice is separated Detachment means, detachment means and the first grasping mechanism are commonly connected to transmission belt；Chip separator frame b30 includes two chips and divides Separate back plate b302, chip separation back plate b302 and chip from side plate b301 with the chip connecting two chips separating side plate b301 Separating side plate b301 together form chip separation longitudinal space, chip separation longitudinal space include for the first grasping mechanism, The upper chip lead-in cavity of two grasping mechanisms and detachment means cooperating and the bottom for housing dice on biochip Chip reclaims chamber.It is also associated between chip separating side plate b301 separating the relative chip of back plate b302 with chip and separate header board B303, upper chip lead-in cavity and lower chips reclaim chamber can be by being connected to two pieces of side plate b301 and relative with back plate b302 Header board b303 is bound.Detachment means include the drive link b304 being connected to transmission belt, the connection being connected to drive link b304 Bar b3041, the first transmission group being driven by drive link b304 and the second transmission group being driven by the first transmission group；Connecting rod B3041 is provided with driving cog b30411；First transmission group includes the first axle being respectively arranged in two chip separating side plates b301 Seat b3042, insert two the first axle bed b3042 and pass through first rotating shaft b3043 of upper chip lead-in cavity and be connected to first First gear b3044 at rotating shaft b3043 two ends, one of first gear b3044 is connected with driving cog b30411 engagement, namely First rotating shaft b3043 passes through two chip separating side plates b301 and the two ends of first rotating shaft b3043 are provided with two first gears b3044；The second axle bed b3045 that second transmission group includes being respectively arranged in two chip separating side plates b301, it is respectively implanted two Individual second axle bed b3045 simultaneously stretches into the second rotating shaft b3046 of upper chip lead-in cavity, is connected to the second rotating shaft b3046 positioned at upper The chip that portion's chip guides one end of intracavity prizes block b3047 and the second gear being connected to the second rotating shaft b3046 other end B3048, second gear b3048 is connected with the engagement of first gear b3044, namely the second rotating shaft b3046 is provided with 2, and each second Rotating shaft b3046 one end passes through chip separating side plate b301 to stretch in upper chip lead-in cavity, also just has 2 chip sled blocks B3047 pries open the dice up and down of biochip simultaneously in the right and left simultaneously；It is additionally provided with positioned at second on second rotating shaft b3046 Rotating shaft back-moving spring b30461 between axle bed b3045 and second gear b3048；Second rotating shaft b3046 leads positioned at upper chip Draw the one end outside chamber and be additionally provided with push handle b3049, push handle b3049 is provided with multi-directional ball b30491；Set in chip separating side plate b301 There is shifting chute b3011, in shifting chute b3011, be interspersed with mobile bar b30111, mobile bar b30111 is provided with and is connected with transmission belt Band swing arm b30114, the two ends of mobile bar b30111 are connected with transfer arm b30112, transfer arm b30112 is connected with for The tabletting b30113 of top pressure multi-directional ball b30491.

First grasping mechanism includes chip mechanical gripper b305, is connected to the linking arm b3051 of chip mechanical gripper b305 With the transmission arm b3052 for driving linking arm b3051, transmission arm b3052 is simultaneously coupled to transmission belt；Transmission arm b3052 with It is provided with anti-excessive lead agency between linking arm b3051, prevent that excessive lead agency includes being connected to the substrate of linking arm b3051 B3053 and one end are connected to substrate b3053 and the other end is connected to the extension spring b3054 of transmission arm b3052；Chip separating side plate B301 is provided with the positive stop b3055 for stopping substrate b3053, implies that when chip mechanical gripper b3052 is by biochip Direct after putting in place, stop continuing to direct action by the conflict of substrate b3053 and positive stop b3055, and extension spring b3054 can continue Continue and be elongated to allow transmission arm b3052 to continue with conveyor belt motion, because before transmission belt is now still to continue to move to drive Drive link b304, the band swing arm b30114 stating, to complete the action of their institutional affiliations.

Second grasping mechanism includes pedestal b306 in chip separation back plate b302, is connected to the pull bar of pedestal b306 B3061, the two pole b3062 of two chips separating side plate b301 of deflection respectively being articulated with pull bar b3061 head end and difference It is articulated with the two chips clamping plate b3063 of two pole b3062；Chip clamping plate b3063 slidably connects guide rod b3064 jointly, Guide rod b3064 two ends are fixedly connected on chip separating side plate b301, guide rod b3064 is arranged with positioned at chip clamping plate b3063 it Between clamping plate back-moving spring b3065, chip clamping plate b3063 can make move toward one another along guide rod b3064, connect outside pull bar b3061 There are pulling machinery, the such as device such as cylinder.The side being located at upper base guiding intracavity in chip separating side plate b301 is provided with mutually Independent upper half guiding cell body b307 and lower half guiding cell body b308, upper half guiding cell body b307 and lower half guiding cell body b308 are altogether With forming chip guiding conduit, upper half guiding cell body b307 is connected with the upper reset baffle block passing outside chip separating side plate b301 B3071, lower half guiding cell body b308 is connected with the lower reset baffle block b3081 passing outside chip separating side plate b301；Chip separates The surface being located at the outer side of upper base lead-in cavity on side plate b301 is provided with the upper positioning gear above upper reset baffle block b3071 The block b3012 and lower position block b3013 below lower reset baffle block b3081, upper position block b3012, upper reset baffle block B3071, lower reset baffle block b3081, lower position block b3013 jointly wear and are connected to release link b3014, upper position block b3012, under Position block b3013 is fixedly connected with release link b3014 respectively, upper reset baffle block b3071, lower reset baffle block b3081 respectively with Release link b3014 is slidably connected；Be arranged with release link b3014 positioned at upper reset baffle block b3071 and upper position block b3012 it Between and be located at back-moving spring b3015 between lower reset baffle block b3081 and lower position block b3013.Upper reset baffle block b3071 And lower reset baffle block b3081 can slide along release link b3014, thus realizing upper half guiding cell body b307 and lower half guiding cell body The move toward one another of b308, can be adaptively relatively distant from when biochip pries open simultaneously, make chip guide conduit wide up and down Degree becomes big.

During real work, transmission belt drives chip mechanical gripper b305 to enter biochip along chip guiding conduit delivery In upper chip lead-in cavity；Before biochip will put stopping in place, transmission belt drives tabletting b30113 top pressure multi-directional ball B30491, so that push handle b3049 drives the second rotating shaft b3046 and opens together with second gear b3048 and chip sled block b3047 Begin to stretch into action, until stretching in the spaced slot in biochip side portion structure；Then transmission belt drives the first transmission group again, First transmission group drives the second transmission group, finally makes chip sled block b3047 start to rotate, pries open action；Then biological core The dice up and down of piece is separated by chip sled block b3047, and lower unit piece can be passed through chip guide channel by chip mechanical gripper b305 Road directs away, and upper dice is unclamped by chip clamping plate b3063, falls into lower chips and reclaims in chamber.

Whole system, by applied technical procedure complicated for biochip, is decomposed into incubation reaction after sample-adding, in cleaning container Embathe, comprehensive flushing, the sub- mistake automatically unloading accommodating base b1, automatically prying open the upper and lower dice of biochip, centrifuge dripping Journey, using lifting two-dimentional machinery arm incubation reaction unit, embathe unit, rinse unit, between post-processing unit transfer biological Chip and accommodating base b1, realize the concurrent job between unit or chained job.

Claims (10)

1. a kind of biochip automated cleaning system, including workbench, located at described worktable lifting two-dimentional machinery arm and company Be connected to multiple unit servomotors of described workbench it is characterised in that: also include common incubation on described workbench Reaction member, embathe unit, rinse unit and post-processing unit；

Described incubation reaction unit includes the first rotating disk (a10), for fixing the chip Container of biochip and located at described First rotating disk (a10) is upper to be used for fixing first fixed stop (a101) of described chip Container；

The described unit that embathes includes the second rotating disk (d10), is used for putting into and embathe biological core on described second rotating disk (d10) The chip rinsing container of piece, for fixing second fixed stop (d101) of described chip rinsing container and located at described workbench The upper headstock gear for opening or closing chip rinsing container；

The described unit that rinses includes the 3rd rotating disk (c10), is used for fixing the of biochip located at described 3rd rotating disk (c10) is upper Three fixed stops (c101), for rinse the flushing framework (c40) of biochip and being used for install described flushing framework (c40) and The vertical reciprocating mechanism (c30) coordinating with described 3rd rotating disk (c10)；

Described post-processing unit includes the 4th rotating disk (b10), is used for fixing described chip appearance on described 4th rotating disk (b10) Put the 4th fixed block plate (b101) of device, being used on described workbench will be detached with biochip for described chip Container Base segregation apparatuss and being used for detached for upper and lower for biochip dice chip detachment apparatus on described workbench；

Described chip Container include accommodating base (b1), the edge retaining wall (b2) on described accommodating base (b1) and located at Biochip sticking department on described edge retaining wall (b2), upper formation is enclosed described accommodating base (b1) by described edge retaining wall (b2) The biochip accommodation space becoming；Described biochip sticking department includes the locking seat on described edge retaining wall (b2) (b21), moving horizontally space and moving horizontally movable block spatially described in being placed in described locking seat (b21) (b22)；Described movable block (b22) is provided with mobile reduction torsion spring (b23), and described locking seat (b21) is provided with positioned at described shifting The fluting (b211) of dynamic reduction torsion spring (b23) both sides, described being respectively arranged at two ends with of mobile reduction torsion spring (b23) inserts two institutes State the extension in fluting (b211)；Described movable block (b22) tail end is also associated with shank of the key, and described shank of the key end is provided with lock nut, The described space that moves horizontally is through to described locking seat (b21) outside, and described shank of the key stretches out described locking seat (b21)；

Described first rotating disk (a10), described second rotating disk (d10), described 3rd rotating disk (c10), described 4th rotating disk (b10) point Not described in one, unit servomotor drives and rotates；Described first rotating disk (a10), described second rotating disk (d10) are also associated with core Piece shaking device.

2. a kind of biochip automated cleaning system according to claim 1 it is characterised in that: described chip embathes appearance Device includes box body (d1), the box mouth located at described box body (d1) top, is above located at described box mouth side located at described box body (d1) Connection shaft seat (d3) and the lid (d2) being connected to described connection shaft seat (d3), described lid (d2) is provided with moving block (d21), described moving block (d21) is provided with the rotating shaft (d211) being connected with described connection shaft seat (d3), described rotating shaft (d211) It is provided with rotation reduction torsion spring, described rotation reduction torsion spring is provided with and inserts described moving block (d21), described connection shaft seat respectively (d3) two end extensions；Described chip rinsing container also includes upper another positioned at described box mouth located at described box body (d1) The cover lock portion of side and the cleaning hole group on described box body (d1), described connection shaft seat (d3) and described cover lock Portion is mutually in the offside on described box body (d1)；Described cleaning hole group includes washing liquid hand-hole (d13), washing liquid tap And tray interior air pressure tap (d15) (d14)；Described cover lock portion includes being connected to the locking base of described box body (d1) Seat (d4), the horizontal sliding space on described locking pedestal (d4) and the sliding shoe being placed on described horizontal sliding space (d5)；Lock (d22), described lock (d22) and described sliding shoe (d5) cooperation locking are additionally provided with described lid (d2)；

Described cover lock portion also includes being inserted vertically into space on described locking pedestal (d4), described horizontal sliding space Converge with the described space intersection that is inserted vertically into, described sliding shoe (d5) head end is inserted vertically in space positioned at described, described lock (d22) can insert described in be inserted vertically in space and described lock (d22) be provided with for described sliding shoe (d5) head end bottom The latch (d221) that face is hooked；

Described sliding shoe (d5) is provided with slip reduction torsion spring (d51), and described locking pedestal (d4) is provided with and resets positioned at sliding Side fluting (d41) of torsion spring (d51) both sides, two described sides are inserted in being respectively arranged at two ends with of described slip reduction torsion spring (d51) Extension in fluting (d41)；Described sliding shoe (d5) front end is provided with the inclined plane for pushing force for described lock (d22) (d54)；Described sliding shoe (d5) tail end is also associated with pull handle, and described pull handle end is provided with draws cap, and described horizontal sliding space passes through Wear outside to described locking pedestal (d4), described pull handle stretches out described locking pedestal (d4).

3. a kind of biochip automated cleaning system according to claim 2 it is characterised in that: described headstock gear bag Include support body (d20), described support body (d20) is provided with left plate (d201) and right plate (d202), on described left plate (d201) It is provided with the cap-opening mechanism for opening cleaning container lid (d2), described right plate (d202) is provided with for closing cleaning container The closing mechanism of lid (d2)；

Described cap-opening mechanism includes uncapping with servomotor (d203), be connected to described in uncap uncapping with servomotor (d203) With shaft coupling (d2031), be connected to described in uncap with the uncapping with screw mandrel (d2032) of shaft coupling (d2031), be connected to described in open Lid screw mandrel (d2032) uncap with walk seat (d2033) and one end be connected to described in uncap with walk seat (d2033) and the other end even It is connected to uncapping with walking frame (d2034) of lock remover；Described lock remover includes unlocking framework (d2035) and located at described unlocking framework (d2035) the hollow aisle (d20351) in, the side of close described right plate (d202) of described unlocking framework (d2035) Side block wall is provided with the pull handle Ka Dao (d20352) communicating with described hollow aisle (d20351), described pull handle Ka Dao (d20352) This side block wall is divided into upside retaining wall (d20353) and downside retaining wall (d20354)；Described upside retaining wall (d20353) and/or The inner surface of described downside retaining wall (d20354) is gradually gone up and this side block to described unlocking framework (d2035) from one end to the other end The relative opposite side retaining wall of wall tilts；

Described closing mechanism includes closing lid servomotor (d204), is connected to the closing lid of described closing lid servomotor (d204) The closing lid screw mandrel (d2042) that with shaft coupling (d2041), is connected to described closing lid shaft coupling (d2041), it is connected to described conjunction The closing lid of lid screw mandrel (d2042) with walk seat (d2043) and one end be connected to described closing lid with walk seat (d2043) and the other end even The closing lid being connected to gland device is with walking frame (d2044)；

Described gland device includes being connected to described closing lid with walking the installing rack (d2045) of frame (d2044) and located at described installing rack (d2045) pinch roller (d2046) on.

4. a kind of biochip automated cleaning system according to claim 1 it is characterised in that: described 3rd rotating disk (c10) be connected with Rotational Cylindrical (c201) below, be provided with inside described Rotational Cylindrical (c201) rolling bearing (c202) and with described turn The central shaft (c203) that dynamic bearing (c202) coordinates；Described vertical reciprocating mechanism (c30) includes sequentially passing through described center The vertical guide rod (c305) of axle (c203) and described 3rd rotating disk (c10) and be used for making described vertical guide rod (c305) carry out vertically Reciprocating vertical guide-bar driving mechanism；The described framework (c40) that rinses includes being connected to the of described vertical guide rod (c305) One framework and the second framework, described first framework is provided with first jet (c407), and described second framework is provided with second nozzle (c408).

5. a kind of biochip automated cleaning system according to claim 4 it is characterised in that: described vertical guide rod drives Motivation structure includes vertical guide rod motor (c301), is connected to vertically leading of described vertical guide rod motor (c301) Bar shaft coupling (c302), the vertical guide rod screw mandrel (c303) being connected to described vertical guide rod shaft coupling (c302), connection Mobile base (c306) and the fixed plate being connected to described Mobile base (c306) in described vertical guide rod screw mandrel (c303) (c304), described vertical guide rod (c305) lower end is connected to described fixed plate (c304), be provided with described central shaft (c203) with The linear bearing that described vertical guide rod (c305) coordinates；

Described first framework includes being connected to the bottom on the top that described vertical guide rod (c305) is piercing in described 3rd rotating disk (c10) Seat (c401) and the erecting bed (c402) on described base (c401), described first jet (c407) is located at described erecting bed (c402) on；

Described second framework include being connected to described vertical guide rod (c305) be piercing in described 3rd rotating disk (c10) top Support axle (c403), be connected to the top board (c404) of described support shaft (c403), be connected to the column of described top board (c404) (c405) and the installation band (c406) that is connected between described column (c405), described second nozzle (c408) is located at described installation On band (c406), described band (c406) of installing is suspended in above described 3rd rotating disk (c10).

6. a kind of biochip automated cleaning system according to claim 1 it is characterised in that: described base separates and fills Put including base separation framework (b20), described base separation framework (b20) includes two pieces of base separating side plates (b201) and connects Base separation back plate (b202) of two pieces of described base separating side plates (b201), described base separating side plate (b201) and described bottom Seat separates back plate (b202) and is collectively forming base separation longitudinal space, and described base separation longitudinal space includes upper base guiding Chamber and lower base reclaim chamber；It is connected with base guide bar (b204), described base divides on described base separation back plate (b202) It is provided with and the base guiding channel (b2011) that is interlinked to the outside in described upper base lead-in cavity and described bottom from side plate (b201) Seat guiding channel (b2011) the base support that coordinates draw section (b2018) and with described base guiding channel (b2011) cooperating Biochip clamp system and base unlocking mechanism, described guide bar (b204) is provided with guiding slide (b2045), described guiding Installing arm (b2041) is connected with slide (b2045), described installing arm (b2041) be provided with base mechanical gripper (b2042) and For the clutch that described biochip clamp system is exerted a force.

7. a kind of biochip automated cleaning system according to claim 8 it is characterised in that: described biochip folder Tight mechanism include axle bed (b2012) on described base separating side plate (b201), insert in described axle bed (b2012) and by Described upper base lead-in cavity passes through the movable axis (b2013) of described base separating side plate (b201), is articulated with described movable axis (b2013) positioned at described base separating side plate (b201) active lever (b2014) of one end outward, be connected to described movable bar The biochip push rod (b2015) of bar (b2014) and be fixedly connected on described base separating side plate (b201) and be articulated with described Support shaft (b2016) in the middle part of active lever (b2014)；Described biochip push rod (b2015) passes through described base guiding logical Road (b2011)；Described base guiding channel (b2011) is provided with baffle plate, and described biochip push rod (b2015) passes through described gear Plate, described biochip push rod (b2015) is arranged with the reset spring offseting with described baffle plate；

Described clutch includes the pushing tow main body (b2043) being fixedly connected in described installing arm (b2041) and located at described top Push away main body (b2043) to be above used for described movable axis (b2013) from described upper base lead-in cavity to described base separating side plate (b201) extrapolated pushing tow face (b2044)；

Described base unlocking mechanism includes being fixedly connected on the unblock framework (b2017) of described base separating side plate (b201) and sets Hollow aisle (b20171) in described unblock framework (b2017), described unblock framework (b2017) is near described upper base The side wall of lead-in cavity side is provided with the shank of the key Ka Dao (b20172) communicating with described hollow aisle (b20171), described shank of the key card This side wall is divided into upper side wall (b20173) and lower wall (b20174) by road (b20172)；Described upper side wall (b20173) and/ Or the inner surface of described lower wall (b20174) is divided near described base by away from described base separation back plate (b202) one end Gradually tilt to hollow aisle (b20171) from back plate (b202) one end；Described upper side wall (b20173) is additionally provided with respect to described The extension of close described base separation back plate (b202) side of lower wall (b20174)；

Described base support draw section (b2018) include located at described base separating side plate (b201) inner surface respectively be located at described bottom The epimere (b20181) of the upper and lower both sides of seat guiding channel (b2011) and hypomere (b20182)；Described epimere (b20181) is provided with phase For the lengthening section of close described base separation back plate (b202) side of described hypomere (b20182), described lengthening section is provided with Base squeezes and cuts somebody's hair (b20183)；

Described installing arm (b2041) is externally connected with haulage gear, and described haulage gear includes power for traction machine (b205), is connected to The traction shaft coupling of described power for traction machine (b205), be connected to described traction shaft coupling traction screw mandrel (b2051), Be connected to the connecting seat (b2052) of described traction screw mandrel (b2051) and one be connected to described connecting seat (b2052) and another Head is connected to the transmission bridge (b2053) of described installing arm (b2041).

8. a kind of biochip automated cleaning system according to claim 1 it is characterised in that: described chip separates and fills Put the driving gear including transmission motor, being connected to described transmission motor, be used for and described driving gear synchronous axial system Driven gear and the transmission belt connecting described driving gear and described driven gear；Described chip detachment apparatus also include chip and divide From frame (b30), for biochip being sent into the first grasping mechanism of described chip separator frame and coordinating described first gripper Structure is used for clamping the second grasping mechanism of dice on biochip and is used for detached for upper and lower for biochip dice fractionation Mechanism, described detachment means and described first grasping mechanism are commonly connected to described transmission belt；Described chip separator frame (b30) bag Include two chips separating side plate (b301) and separate back plate (b302) with the chip connecting two pieces of described chip separating side plates (b301), Described chip separation back plate (b302) together form chip with described chip separating side plate (b301) and separates longitudinal space, described Chip separation longitudinal space is included for described first grasping mechanism, described second grasping mechanism and described detachment means cooperating Upper chip lead-in cavity and for house dice on biochip lower chips reclaim chamber.

9. a kind of biochip automated cleaning system according to claim 8 it is characterised in that: described detachment means bag Include the drive link (b304) being connected to described transmission belt, the connecting rod (b3041) being connected to described drive link (b304), by described The first transmission group and the second transmission group being driven by described first transmission group that drive link (b304) drives；Described connecting rod (b3041) it is provided with driving cog (b30411)；

The first axle bed (b3042) that described first transmission group includes being respectively arranged on two described chip separating side plates (b301), Insert two described first axle beds (b3042) and pass through the first rotating shaft (b3043) of described upper chip lead-in cavity and be connected to The first gear (b3044) at described first rotating shaft (b3043) two ends, one of described first gear (b3044) and described biography Dynamic tooth (b30411) engagement connects；

The second axle bed (b3045) that described second transmission group includes being respectively arranged on two described chip separating side plates (b301), It is respectively implanted two described second axle beds (b3045) and stretch into second rotating shaft (b3046) of described upper chip lead-in cavity, connect Prize block (b3047) in the chip that described second rotating shaft (b3046) is located at one end that described upper chip guides intracavity and be connected to The second gear (b3048) of described second rotating shaft (b3046) other end, described second gear (b3048) and described first gear (b3044) engagement connects；It is additionally provided with positioned at described second axle bed (b3045) and described second on described second rotating shaft (b3046) Rotating shaft back-moving spring (b30461) between gear (b3048)；

Described first grasping mechanism includes chip mechanical gripper (b305), is connected to the connection of described chip mechanical gripper (b305) Arm (b3051) and be used for driving the transmission arm (b3052) of described linking arm (b3051), described transmission arm (b3052) is simultaneously connected with In described transmission belt；

Described second grasping mechanism includes pedestal (b306) on described chip separation back plate (b302), is connected to described base The pull bar (b3061) of seat (b306), it is articulated with the described chip separating side plate of two pieces of deflection respectively of described pull bar (b3061) head end (b301) two poles (b3062) and the two chips clamping plate (b3063) being hingedly connected to two described poles (b3062)； Described chip clamping plate (b3063) slidably connects guide rod (b3064) jointly, and described guide rod (b3064) two ends are fixedly connected on institute State chip separating side plate (b301), described guide rod (b3064) is arranged with the clamping plate between described chip clamping plate (b3063) Back-moving spring (b3065).

10. a kind of biochip automated cleaning system according to claim 1 it is characterised in that: described chip rocks Device includes chassis (e1) and telophragma (e2), and described chassis (e1) is connected to described unit servomotor and is watched by described unit Take motor to drive, described telophragma (e2) is located at described chassis (e1) and described first rotating disk (a10)/described second rotating disk (d10), between, between described chassis (e1) and described telophragma (e2), it is provided with multiple the first connectors (e3) for supporting, institute State be provided between telophragma (e2) and described first rotating disk (a10)/described second rotating disk (d10) multiple for supporting and making described Second connector (e4) of the first rotating disk (a10)/described second rotating disk (d10) eccentric rotary, one of described second connection Part (e4) is connected with lead agency；

Described first connector (e3) includes being connected to the upper pedestal (e31) of described telophragma (e2), being connected to described chassis (e1) lower base (e32) and the breeze way (e33) being connected between described upper pedestal (e31) and described lower base (e32)；

Described second connector (e4) include being fixedly connected on described in take over a business (e0) upper axle bed (e41), be fixedly connected on described The lower axle bed (e42) of telophragma (e2) and the rotation being simultaneously rotationally connected with described upper axle bed (e41) and described lower axle bed (e42) Body；Described rotor is included main body block (e43), is rotated with described upper axle bed (e41) located at described main body block (e43) upper surface The upper connecting shaft (e431) that connects and rotating located at described main body block (e43) lower surface and described lower axle bed (e42) is connected Lower connecting shaft (e432), the axial line of the axial line of described upper connecting shaft (e431) and described lower connecting shaft (e432) is not same On straight line；

Described lead agency includes drive motor (e5) and described drive motor (e5) transmission company on described chassis (e1) The belt pulley (e51) connecing and the wheel shaft (e52) being connected with described belt pulley (e51), described wheel shaft (e52) is connected with described second The lower connecting shaft (e432) of part (e4) is fixedly connected or is integrally formed.