CN106333916B

CN106333916B - Scalp nourishing liquid for treating alopecia and promoting hair growth

Info

Publication number: CN106333916B
Application number: CN201610814302.1A
Authority: CN
Inventors: 赵文忠; 陈贤鹰; 林学镁; 洪盛杰; 谷志静; 周起; 董志扬
Original assignee: Lafang China Co ltd
Current assignee: Lafang China Co ltd
Priority date: 2016-09-09
Filing date: 2016-09-09
Publication date: 2020-05-15
Anticipated expiration: 2036-09-09
Also published as: CN106333916A

Abstract

The invention belongs to the field of daily chemicals, and particularly relates to a scalp nourishing liquid which comprises the following components: (A) hop extract in an amount of 1-5% by weight of the tonic solution; (B) rosemary extract accounting for 0.1-2% of the weight of the nutrient solution; (C) swertia extract accounting for 0.05-2% of the weight of the nutrient solution; (D) auxiliary active ingredients accounting for 0.0075-0.15% of the weight of the nourishing liquid, wherein the auxiliary active ingredients are artemia salina extracts; (E) a cosmetically acceptable carrier. The invention is characterized in that the four active components in the nutrient solution have mutual synergistic effect, thereby preventing and relieving hair loss, resisting androgenetic alopecia, preventing complete atrophy of hair follicles and newly growing hair.

Description

Scalp nourishing liquid for treating alopecia and promoting hair growth

Technical Field

The invention belongs to the field of daily chemicals, and particularly relates to a scalp nutrient solution which has the functions of treating alopecia and promoting hair growth.

Background

The alopecia is a white word, which can not be strictly called a disease, but more belongs to a biological disorder, and brings impact to the psychology of people. The common androgenic alopecia is common in men.

The number of hairs of men is counted to be between 10 and 15 ten thousand on average, and the number of hairs dropped per day is between 80 and 100, which belongs to the normal range. However, it is important to maintain an average number of hairs in order to prevent the occurrence of alopecia, that is, to maintain a normal life-death cycle for each hair.

According to the literature, the most common alopecia is caused by androgenetic alopecia, which is induced by the stimulation of sex hormones to hair follicle change and hair loss caused by the influence of genetic factors and aging factors. Testosterone, an androgen produced by reproductive organs, plays an important role during sex hormone-induced alopecia. However, 50% of circulating testosterone is known to be produced by peripheral tissues. In hair follicles, a 5-a-reductase (also called testosterone reductase), converts testosterone into Dihydrotestosterone (DHT), which is more active than testosterone and accumulates in the follicular cell membrane to reduce the function of the follicle and thus prevent hair growth.

In addition, according to the related literature, the hair loss of the scalp at the top of the head is reported to be associated with the sex hormone in different degrees with other parts of the body. In other words, the secretion of androgens at the early adolescence stage is rather beneficial to the growth of hair in body parts (e.g. beard, chest hair, underarm hair, leg hair, etc.), while at the same time the growth of hair in the top of the head is inhibited. This may occur in connection with genetic variability.

In women, the phenomenon of alopecia caused by male hormones is counteracted because the expression of male hormones is suppressed by the large amount of secreted estrogen (female hormone). However, with the arrival of menopause, the secretion of female hormones corresponding to women is continuously reduced, and at the same time, circulating testosterone continuously occupies the upper wind, thus causing the same symptomatology as male alopecia.

There is currently no adequate evidence for hormonal methods to explain the onset of hair loss after menopause in men.

The first histological changes that occur in the connective tissue of the hair follicle appear as degenerative lesions and result in a change in the basophilicity around the blood vessels. Even though the hair follicles in the scalp region begin to shrink and thus produce very small vellus hairs, there is still a small fraction of static terminal follicles that can stimulate growth.

In addition to hormonal causes, other factors that contribute to hair loss include: lack of care and aging of hair follicle cells due to external aggression; loss of hair nutrition due to reduced microcirculation function of the scalp; hair cells multiply very slowly. Hair is accompanied by the aging process of the human body, as is skin, and aging of hair includes aging of hair shaft and aging of hair follicle, both aging cases being accompanied by falling and shedding of hair. Generally, aging of the hair shaft easily causes the hair shaft to weaken or break, and aging of the hair follicle causes hair loss. The aging of hair dryness is mainly caused by exogenous factors, which are mainly expressed as: split ends, lack of shine, yellow and dull, rough, dry, difficult to comb, and the like. The aging of hair dryness is mainly caused by exogenous factors such as light, wind, rain, air pollution, chemicals in seawater or swimming pools, physical factors such as hot blowing, straightening and excessive combing of hair, and chemical factors such as hair bleaching, dyeing and perming. Aging of hair follicles is mainly caused by endogenous factors, such as excessive free radicals generated by reasons of decreased free radical scavenging ability, endocrine disorders in organisms, decreased immune function and the like in the natural aging process of human bodies, genetic factors, nutrient deficiency and the like, and mental factors such as depressed mood, excessive stress, mental stress and the like, life style and the like. The aging of hair follicles is mainly manifested by the whitening and thinning of hair, hair follicle reduction and hair loss, and the like.

In the past, with the improvement of living standard and the development of society, people pay more and more attention to the construction of personal images, and the role played by the personal images in social life and work is more and more important. Therefore, many cosmetic companies have been engaged in the development of hair care and scalp care cosmetics, and it is desired to produce a product for reducing hair loss while having a good effect on promoting hair growth.

Disclosure of Invention

The technical personnel of the invention prepares and obtains a scalp nourishing liquid according to different proportions on the basis of aiming at the reasons causing alopecia, and the scalp nourishing liquid has an auxiliary active substance for regulating the hair growth function.

The invention relates to a scalp nourishing liquid for treating alopecia and promoting hair growth, which comprises the following components:

(A) hop extract in an amount of 1-5% by weight of the tonic solution;

(B) rosemary extract accounting for 0.1-2% of the weight of the nutrient solution;

(C) swertia extract accounting for 0.05-2% of the weight of the nutrient solution;

(D) auxiliary active ingredients accounting for 0.0075-0.15% of the weight of the nourishing liquid, wherein the auxiliary active ingredients are artemia salina extracts;

(E) cosmetically acceptable carrier:

ethanol accounting for 8-35% of the weight of the nutrient solution;

polyoxyethylene 40 hydrogenated castor oil 0.05-3 wt% of the nourishing liquid;

d-panthenol accounting for 0.05-2% of the weight of the nutrient solution;

proper amount of preservative, essence, pigment, pH regulator and the balance of deionized water.

The scalp nourishing liquid comprises 1.5-3% of hop extract by weight; the weight percentage of the rosemary extract in the nutrient solution is 0.5-1%; the weight percentage of the swertia extract in the nourishing liquid is 0.1-0.8%; the artemia salina extract accounts for 0.03-0.075% of the nourishing liquid by weight.

In the cosmetically acceptable carrier, the alcohol accounts for 23-29% of the weight of the nutrient solution, the polyoxyethylene 40 hydrogenated castor oil accounts for 0.1-1.5% of the weight of the nutrient solution, and the D-panthenol accounts for 0.1-1% of the weight of the nutrient solution.

Besides the above four active ingredients, the composition of the present invention further comprises cosmetically acceptable ingredients such as ethanol, water-alcohol medium and other formulation auxiliary ingredients such as vitamins, pigments, essences, etc.

The invention has the advantages that:

alopecia is the result of a very complex physiological process. The scientific mixture ratio of the three plant extracts and the artemia salina extract has a synergistic anti-alopecia effect, and various positive factors such as scalp antioxidation, 5-a-reductase activity inhibition, generation of Dihydrotestosterone (DHT) causing alopecia, keratinocyte proliferation promotion, stimulation and activation of hair follicles, energy supplement of scalp and hair follicles and the like are comprehensively considered from multiple aspects such as prevention, nourishing, protection, treatment and the like, so that the anti-androgenetic alopecia is prevented and alleviated, the complete atrophy of the hair follicles is prevented, and the hairs are newly generated. The effect is proved by clinical test data of clinical volunteers.

Drawings

FIG. 1 is a diagram of the hair condition of volunteers before using the product of the present invention;

FIG. 2 is a diagram of the hair condition of the same volunteer 90 days after using the product of the present invention.

Detailed Description

Rosmarinus plant belonging to Labiatae, belonging to the genus of Labiatae, is more than 1 m high, is evergreen shrub, is erect, has gray green leaves, is narrow and sharp, has pine leaves with pine fragrance, and can be regarded as a medicinal herb for enhancing memory from old times. The flower is white or light green. In the invention, rosemary leaves are used as crude drug for extraction, dry rosemary leaves are extracted (leached) by ethanol water solution with the weight ratio of 7-10% and the solvent of 50% by weight, and the rosemary extract is obtained by filtering after 24 hours. The rosemary plant extract contains antioxidant substances, and the main components are phenol, acid and flavonoid components with antioxidant function; rosemary oil is a liquid oil composed of more than 30 volatile components. The rosemary extract has high-efficiency and nontoxic antioxidant effect, and can be widely applied to the industries of food, functional food, spice, condiment, daily chemical industry and the like. And (5) refining. Many documents and studies have described the biological activity of rosemary extracts and are effective in the treatment of alopecia (1) rosemary extracts have a cell membrane containing function to neutralize free radicals involved in oxidation reactions in tissues and (2) inhibit the production of Dihydrotestosterone (DHT) which causes alopecia.

The hop is a perennial herb original plant of the Cannabaceae family, the Humulus genus, the hop tendrils grow more than 6m, the hop tendrils are full and dense fine hairs and have barbs, leaf pair, paper, oval or palm shape, 3-5 cracks and coarse saw teeth, the original Europe, America and Asia can be used for brewing beer and medicinal hops, the hop contains resin, humulone, isohumulone, lupulone and the like, volatile oil, myrcene, humulene, linalool, lupeol and the like, furthermore, tannin, flavone compounds, choline, fructose, cane sugar, glucose and the like, the hop raw material and the production area use natural hops or hop particles and compressed hop as raw materials, the China Xinjiang land is produced, the hop raw material is crushed by the production process, the hop extract is produced by a liquid CO2 extraction technology, the hop extract is golden yellow to amber viscous liquid, has typical hop fragrance, the main components of the hop extract are α -acid, β -acid and the like, the main components of the hop extract are respectively, the natural testosterone is more than 45%, the natural acid peroxide addition agent, the natural antioxidant is used for inhibiting the natural antioxidant, the anti-5-dihydrotestosterone is used for inhibiting the natural antioxidant, the active ingredient of the product, the anti-5 and the anti-5 anti-dihydrotestosterone-enriched active ingredient of the product has the characteristic of the anti-enriched hop extract of the product under the full-enriched hop.

The swertia plant, an annual herb, 10-40 cm higher, has a single or branched stem, a quadrangular prism shape, a purple-carrying leaf pair, no stalk, a threadlike lance shape, 2-4 cm in length, tapered at the tip, narrow at the base, and a whole margin, and contains swertia herb, about 2-4% of swertia herb, swertia pseudochinensis, Gentiana lutea glucoside and the like, contains isovitexin, isoorientin, 1, 3-dihydroxy-4, 5-dimethoxyxanthone, and 1-o- β -D-glucopyranoside and 3- β -D-glucopyranoside of the xanthone, and contains swertia pseudonin and swertia glycoside.

Auxiliary active ingredient

The auxiliary active component of the invention combines BiotHAIRapy of the American Ashland company^TMHair care research and development platform based on biotechnology: 1, a unique research and development platform based on the technical capability of ex vivo scalp hair follicle tissue section research; 2. concerns about hair root health to provide long lasting hair styling benefits; 3. innovative biofunctional materials are focused on the scalp, key biomarkers of hair follicle health.

The auxiliary active ingredient of the invention is a hair growth regulating ingredient selected from Ashland (Arshland) such as, a corn extract Capauxein^TMBiofunc ion, INCI nomenclature: water (and) glycerol (and) hydrolyzed corn protein, the corn extract elicits inspiration by key communication biomarkers that govern hair density, fullness; rice extract Dynagen^TMBiofunc ion, INCI nomenclature: water (and) glycerol (and) hydrolyzed yeast protein; a rice protein, Protectagen^TMbionomi, INCI name: water (and) glycerol (and) hydrolyzed rice protein, inspirational rice extract from the 'hair stem cell system', helps to relieve stress and protect hair growth; an artemia salina extract GP4GSP Biofunct ions comprises artemia salina extract, phenoxyethanol, potassium sorbate and water, wherein: water: 97.366%, Artemia Extract 1.5%, phenoxyethanol: 1.0% potassium sorbate: 0.134%, wherein Artemia Extract is active ingredient. Artemia are also known as brine artemia. Chinese folks also called saltworm or brine shrimp, belong to the arthropoda, gill subphylum, crustacea, gill podophiala, amantada, saltwater Artemia (Artemia) as an important good experimental animal material of the food biology family, and have been widely regarded by people. The artemia salina extract is a plankton extract with super-strong energy efficiencyThe fruit, being rich in nucleotides, proves to have an effective protective action against the external environmental stresses (including photoaging and ambient temperature aging stresses), a moisturizing action, since the proteins contained combine with other moisturizing ingredients to keep the scalp moist and prevent dehydration.

More efficacy tests prove that the artemia extract has strong effect on regulating cell stress factors related to sensitivity so as to play a role in calming scalp soothing, and recent research proves that the artemia extract has an effective regulating effect in the hair regeneration process (J.Cosmet.Sci.,62, 469-482 September/October 2011). The auxiliary active ingredient of the invention is preferably ARTEMIA (ARTEMIA) extract, the ARTEMIA (ARTEMIA) extract refers to ARTEMIA active ingredient in the product name GP4GSPBIOfunctional of Asia-Islands, and the weight percentage of the ARTEMIA extract in the scalp nourishing liquid of the invention is 0.0075-0.15%, and is further optimized to be 0.03-0.075%.

Cosmetically acceptable carrier: the invention also comprises a cosmetically acceptable carrier, such as a mixed solution of absolute ethyl alcohol and deionized water as a solvent, wherein the absolute ethyl alcohol accounts for 8-35% of the weight of the nutrient solution, and is further optimized to be 23-29%; the humectant adopts glycerin, propylene glycol, 1.3 butanediol and D-panthenol, the D-panthenol is preferably selected in the invention, and the weight percentage of the D-panthenol in the nutrient solution is 0.05-2%, and is further optimized to be 0.1-1%; polyoxyethylene 40 hydrogenated castor oil accounting for 0.05 to 3 weight percent of the invention, and polyoxyethylene 40 hydrogenated castor oil accounting for 0.1 to 1.5 weight percent of the invention is optimized; appropriate amount of antiseptic, essence, pigment, pH regulator, and components with caring effect such as plant extract with skin or hair caring effect, hydrolyzed collagen, fibroin, and lanolin derivatives; photo-protecting agents, antioxidants, free radical scavengers; hair glossing agents, vitamins, and the like.

The scalp tonic of the present invention comprises a method of using, for example, a sufficient amount of hair tonic on the scalp, and gently patting and massaging with the palm of the fingers until absorption.

The combination of the three plant extracts and the artemia salina extract is very suitable for a hair protective agent and a hair growth promoter, and the three plant extracts are used as active ingredients to be applied to hair products and obtain nourishing and protecting effects, so that the androgenetic alopecia can be better resisted. Thus, hair loss can be reduced, complete atrophy of hair follicles can be prevented, and hair can be newly produced. The effect is proved by clinical test data of clinical volunteers.

From the quantitative point of view, the composition of the hair tonic of the present invention comprises the following components:

the weight percentage of the three extracts and the auxiliary active ingredients in the nourishing liquid is 1.1575-9.15%. The rest components are 90.8% -98.8%.

The four active substances correspond to the following proportions:

H＞R＞Sw＞Coa

wherein: h-weight percentage of hop extract, R-weight percentage of rosemary extract, Sw-weight percentage of swertia extract and weight percentage of Coa auxiliary active component.

Four active matters, each of which accounts for the following weight percentage of the nutrient solution

The weight percentage of the H-hop extract in the nourishing liquid of the invention is 1-5%,

the weight percentage of the R-rosemary extract in the nourishing liquid is 0.1-2%

Sw-swertia extract accounts for 0.05-2% of the weight of the nutrient solution

The Coa-auxiliary active component, the artemia extract accounts for 0.0075-0.15% of the weight of the nourishing liquid

Four active matters, each of which accounts for the weight percentage of the nutrient solution of the invention, are further optimized as follows:

the weight percentage of the H-hop extract in the nourishing liquid of the invention is 1.5-3%,

the weight percentage of the R-rosemary extract in the nourishing liquid is 0.5-1%

The Sw-swertia pseudochinensis extract accounts for 0.1 to 0.8 percent of the weight of the nutrient solution,

the Coa-auxiliary active component and the artemia extract account for 0.03 to 0.075 percent of the nourishing liquid by weight

The following are examples of the scalp tonic of the present invention:

examples

The following are non-limiting examples of the scalp tonic of the present invention. These examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention. In the examples, all concentrations are in weight percent unless otherwise specified.

Examples I to V

Examples VI to X

The best embodiment of the invention is as follows:

components	Weight (%)
		Anhydrous ethanol	28.0
Polyoxyethylene 40 hydrogenated castor oil	1.4
		Hop extracts	2.8
Rosemary extract	0.9
		Swertia extract	0.7
Artemia salina extract	0.07
		D-panthenol	0.95
Antiseptic, essence, pigment, and pH regulator	Proper amount of
		Deionized water	Adding to 100 percent

Verification of alopecia prevention effect

The using method comprises the following steps: arranging the using amount of about 6 ml of the nourishing liquid in an ampoule every day, insisting that one ampoule is used every day, and before and during the using of the hair nourishing liquid, the hair is washed 2-3 times per week, and weak acid shampoo is used for washing hair (pH value is 5.5); after shampooing, the hair was wiped dry with a towel, the tonic solution in the ampoule was applied to the hair and the scalp was gently massaged for 1 minute, and the hair was optimally used in a semi-dry state after shampooing.

The test method comprises the following steps: 60 volunteers with alopecia were selected, scalp healthy individuals without allergy, wound and systemic topical disease were requested, and the ratio of the growth phase and resting phase of the hair of the volunteers was lower than that of the normal state by image observation, and divided into 4 groups, which correspond to the use of example II (first group), IX (second group), comparative 1 (third group) and comparative 2 (fourth group), respectively. The use was continued for 90 days, and sensory evaluation and hair image evaluation were performed at 45 days of use and 90 days of use, respectively. The sensitization assessment of volunteers against hair loss before and after application of the scalp tonic according to the present invention is shown in tables 1 and 2.

TABLE 1

By way of table 1, inventive example ii (first group), inventive example ix (second group), inventive comparative 1 (third group) and inventive comparative 2 (fourth group), were used for 90 days, and the results of sensory evaluation at 45 days of use and 90 days of use, respectively, showed that: the percentage of the amount of hair loss reduced in the first group and the second group is significantly higher than that in the third group and the fourth group, as compared with comparative example 1 (the third group) and comparative example 2 (the fourth group) of the present invention, which shows that the scalp tonic for treating hair loss and promoting hair growth according to the present invention has a good hair loss preventing effect; through comparison of the third group and the fourth group, it is found that: the fourth group, i.e., the example of comparative example 2 of the present invention, all had higher percentage of hair loss (combing, washing, sleeping) than the example of comparative example 1 of the present invention, which shows that the hair growth regulating factor of comparative example 2, and the addition of artemia salina extract has certain effect on hair loss prevention and hair fixation.

TABLE 2

By way of table 2, inventive example ii (first group), inventive example ix (second group), inventive comparative 1 (third group) and inventive comparative 2 (fourth group), continued use for 90 days and evaluation of the improvement of hair growth at 45 days of use and 90 days of use, respectively, showed: the percentage of hair growth-promoting effect of the first and second groups, which are significantly higher than the third and fourth groups, in comparison with the present invention comparative group 1 (third group) and the present invention comparative group 2 (fourth group), shows that the hair growth-promoting effect of the scalp tonic for treating alopecia and promoting hair growth according to the present invention is excellent in that fine hairs are overgrown on the original thin hairs after 90 days of use by the subjects, as shown in fig. 1 and fig. 2, respectively. This is a significant sign of the return of the hair from telogen to anagen.

Through comparison of the third group and the fourth group, it is found that: the fourth group, comparative example 2 of the present invention, showed a higher percentage of hair growth than comparative example 1 of the present invention, indicating that the artemia salina extract, the only active ingredient contained in comparative example 2, had a certain effect on hair growth promotion.

Claims

1. A scalp tonic for treating hair and promoting hair growth, which comprises:

the weight percentage of the components is%

28.0 percent of absolute ethyl alcohol

Polyoxyethylene 40 hydrogenated castor oil 1.4

Hop extract 2.8

Rosemary extract 0.9

Herba Swertiae Bimaculatae extract 0.7

Artemia salina extract 0.07

Panthenol 0.95

Proper amounts of preservative, essence, pigment and pH regulator are added into deionized water to 100 percent.