CN106310359A - 一种复合生物材料 - Google Patents

一种复合生物材料 Download PDF

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Publication number
CN106310359A
CN106310359A CN201610750316.1A CN201610750316A CN106310359A CN 106310359 A CN106310359 A CN 106310359A CN 201610750316 A CN201610750316 A CN 201610750316A CN 106310359 A CN106310359 A CN 106310359A
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Prior art keywords
parts
biological material
weight
compound biological
composite biological
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陆应生
苏情
王君
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GUILIN XINYI REFRIGERATION EQUIPMENT Co Ltd
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GUILIN XINYI REFRIGERATION EQUIPMENT Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0042—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0038—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids

Abstract

本发明涉及一种复合生物材料，按重量份计包括：氰基丙烯酸丁酯25～35份，纤维蛋白4～6份，丙二醇4～6份，骨胶原7～10份，魔芋葡甘聚糖2～5份，明胶5～7份。本发明产品的吸水膨胀率高于常规的水凝胶材料，另外将水凝胶材料干燥后测定了其断裂强度，其断裂强度也高于常规得水凝胶材料，并且本发明的水凝胶敷料材料具有良好的生物相容。

Description

一种复合生物材料
技术领域
本发明涉及医用生物新材料技术领域，具体是一种复合生物材料。
背景技术
皮肤是人体的重要屏障，各类手术、外伤、烧伤、皮炎等均会导致皮肤破坏和缺损，引起各种各样的创伤，创伤修复是医学发展的重要领域，对于减轻病患痛苦，早日康复和避免修复后留下疤痕有着重要的意义。
发明内容
本发明所要解决的技术问题是提供一种复合生物材料。
本发明解决上述技术问题的技术方案如下：一种复合生物材料，按重量份计包括：
本发明的有益效果是：本发明产品的吸水膨胀率高于常规的水凝胶材料，另外将水凝胶材料干燥后测定了其断裂强度，其断裂强度也高于常规得水凝胶材料，并且本发明的水凝胶敷料材料具有良好的生物相容。
在上述技术方案的基础上，本发明还可以做如下改进。
优选的，按重量份计包括：
优选的，还包含有5～12重量份的大豆蛋白粉。
优选的，按重量份计包括：
按重量份计包括：
以下对本发明的原理和特征进行描述，所举实例只用于解释本发明，并非用于限定本发明的范围。
具体实施方式
以下对本发明的原理和特征进行描述，所举实例只用于解释本发明，并非用于限定本发明的范围。
实施例1
一种复合生物材料，按重量份计包括：氰基丙烯酸丁酯25份、纤维蛋白6份、丙二醇5份、骨胶原10份、魔芋葡甘聚糖2份和明胶7份。
将各原料依次加入反应器中，并升温至65-85℃,搅拌10分钟，充分混合均匀即可。
实施例2
一种复合生物材料，按重量份计包括：氰基丙烯酸丁酯25份、纤维蛋白6份、丙二醇5份、骨胶原10份、明胶7份、魔芋葡甘聚糖3份和大豆蛋白粉6份。
将各原料依次加入反应器中，并升温至65-85℃,搅拌10分钟，充分混合均匀即可。
实施例3
一种复合生物材料，按重量份计包括：氰基丙烯酸丁酯35份、纤维蛋白5.5份、丙二醇5份、骨胶原8份、明胶7份、魔芋葡甘聚糖2份和芦荟粉6份。
将各原料依次加入反应器中，并升温至65-85℃,搅拌10分钟，充分混合均匀即可。
实施例4
一种复合生物材料，按重量份计包括：氰基丙烯酸丁酯35份、纤维蛋白5.5份、丙二醇5份、骨胶原8份、明胶7份、魔芋葡甘聚糖4份和大豆蛋白粉7份。
将各原料依次加入反应器中，并升温至65-85℃,搅拌10分钟，充分混合均匀即可。
对本发明中实施例1-4中制得的生物材料，检测结果见表下：
吸水膨胀率(％) 断裂强度(MPa)
实施例1 278 0.95
实施例2 271 0.94
实施例3 265 0.8
实施例4 260 0.82
本发明产品的吸水膨胀率高于常规的水凝胶材料，另外将水凝胶材料干燥后测定了其断裂强度，其断裂强度也高于常规得水凝胶材料，并且本发明的水凝胶敷料材料具有良好的生物相容。
尽管上面已经示出和描述了本发明的实施例，可以理解的是，上述实施例是示例性的，不能理解为对本发明的限制，本领域的普通技术人员在本发明的范围内可以对上述实施例进行变化、修改、替换和变型。

Claims (5)

1.一种复合生物材料，其特征在于，按重量份计包括：
2.根据权利要求1所述一种复合生物材料，其特征在于，按重量份计包括：
3.根据权利要求1所述一种复合生物材料，其特征在于，还包含有5～12重量份的大豆蛋白粉。
4.根据权利要求3所述一种复合生物材料，其特征在于，按重量份计包括：
5.根据权利要求1所述一种复合生物材料，其特征在于，还包括1～10重量份的芦荟粉。
CN201610750316.1A 2016-08-29 2016-08-29 一种复合生物材料 Pending CN106310359A (zh)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1785444A (zh) * 2005-12-07 2006-06-14 浙江大学 胶原－壳聚糖和硅橡胶双层皮肤再生支架及其制备方法
CN102380121A (zh) * 2011-10-31 2012-03-21 昆明理工大学 一种降解可控的医用防粘连材料及其制备方法
CN102755668A (zh) * 2011-04-29 2012-10-31 天津市赛宁生物工程技术有限公司 可塑型医用骨泥
CN103483625A (zh) * 2013-09-09 2014-01-01 戴建英 可吸收降解的多用途生物相容性材料
CN105617452A (zh) * 2015-12-31 2016-06-01 佛山铭乾科技有限公司 一种医用生物新材料

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1785444A (zh) * 2005-12-07 2006-06-14 浙江大学 胶原－壳聚糖和硅橡胶双层皮肤再生支架及其制备方法
CN102755668A (zh) * 2011-04-29 2012-10-31 天津市赛宁生物工程技术有限公司 可塑型医用骨泥
CN102380121A (zh) * 2011-10-31 2012-03-21 昆明理工大学 一种降解可控的医用防粘连材料及其制备方法
CN103483625A (zh) * 2013-09-09 2014-01-01 戴建英 可吸收降解的多用途生物相容性材料
CN105617452A (zh) * 2015-12-31 2016-06-01 佛山铭乾科技有限公司 一种医用生物新材料

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Application publication date: 20170111