CN106266454A - 一种可有效治疗股骨头坏死的丸剂药物及其制备方法 - Google Patents
一种可有效治疗股骨头坏死的丸剂药物及其制备方法 Download PDFInfo
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- CN106266454A CN106266454A CN201610805069.0A CN201610805069A CN106266454A CN 106266454 A CN106266454 A CN 106266454A CN 201610805069 A CN201610805069 A CN 201610805069A CN 106266454 A CN106266454 A CN 106266454A
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Abstract
本发明属于中医药技术领域,目的是根据中医对股骨头坏死的认识机理而提供的一种可有效治疗股骨头坏死的丸剂药物,所述药物的各个组分及其质量份比如下:当归8~16g、三七3~10g、川芎5~10g、熟地黄10~32g、人参3~10g、赤芍6~12g、乳香(制)5~16g、黄芪15~28g、没药(制) 5~20g、补骨脂(盐炙) 6~16g、骨碎补10~20g、肉苁蓉10~16g、仙灵脾3~10g、土鳖虫(酒炙)3~10g、全蝎2.5~5g、穿山甲(炮)8~16g、藏红花3~10g、鹿角胶3~10g、血竭0.5~1.5g;本发明提供的药物是一个标本兼治的中药组方。
Description
技术领域
本发明涉及中医药技术领域,具体涉及一种可有效治疗股骨头坏死的丸剂药物,特别是供股骨头坏死患者使用的丸剂药物及其制备方法的领域。
背景技术
股骨头坏死是一个病理演变过程,初始发生在股骨头的负重区,应力作用下坏死骨骨小梁结构发生损伤即显微骨折以及随后针对损伤骨组织的修复过程。造成骨坏死的原因不消除,修复不完善,损伤-修复的过程继续,导致股骨头结构改变、股骨头塌陷、变形,关节炎症,功能障碍。股骨头坏死固然会引起病痛,关节活动和负重行走功能障碍,但人们不要受“坏和死”文字含义恐怖的影响,股骨头坏死病变,毕竟局限,累及个别关节,可以减轻,消退和自愈,即便严重,最后还可以通过人工髋关节置换补救,仍能恢复步行能力。
那么,就如何找到一种可有效治疗上述股骨头坏死的药物,是我们目前急需要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗股骨头坏死上,人们逐渐意识到了中医治疗上述股骨头坏死的优点,且在治疗过程中毒副作用小、费用低等优势,针对现有西医治疗上述股骨头坏死的现状,本发明的目的是在于提供一种可有效治疗股骨头坏死的丸剂药物,以解决股骨头坏死患者早日恢复健康的问题。该药物是以常见的中药为原料,具有见效快、疗效显著等特点,并可有效治疗上述股骨头坏死一证。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种可有效治疗股骨头坏死的丸剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归8~16g、三七3~10g、川芎5~10g、熟地黄10~32g、人参3~10g、赤芍6~12g、乳香(制)5~16g、黄芪15~28g、没药(制) 5~20g、补骨脂(盐炙) 6~16g、骨碎补10~20g、肉苁蓉10~16g、仙灵脾3~10g、土鳖虫(酒炙)3~10g、全蝎2.5~5g、穿山甲(炮)8~16g、藏红花3~10g、鹿角胶3~10g、血竭0.5~1.5g。
一种可有效治疗股骨头坏死的丸剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归10~14g、三七7~9g、川芎7~9g、熟地黄15~28g、人参7~9g、赤芍8~11g、乳香(制)10~14g、黄芪18~25g、没药(制) 12~17g、补骨脂(盐炙) 10~14g、骨碎补12~17g、肉苁蓉11~14g、仙灵脾7~9g、土鳖虫(酒炙)7~9g、全蝎3~4.5g、穿山甲(炮)10~14g、藏红花7~9g、鹿角胶7~9g、血竭0.8~1.2g。
一种可有效治疗股骨头坏死的丸剂药物及其制备方法,其特征在于,所述“最佳方案”的药物的各个组分及其质量份比如下所示:
当归13g、三七8g、川芎8g、熟地黄25g、人参8g、赤芍10g、乳香(制)13g、黄芪22g、没药(制) 15g、补骨脂(盐炙) 13g、骨碎补15g、肉苁蓉13g、仙灵脾8g、土鳖虫(酒炙)8g、全蝎4g、穿山甲(炮)13g、藏红花8g、鹿角胶8g、血竭1g。
一种可有效治疗股骨头坏死的丸剂药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比共研为极细末待用;
B、按照传统制备中药水丸剂的方法,将研磨好的极细末药物过筛后,放入药器中混合拌均,然后制备成水丸剂(其水丸的粒度为:4.8mm-4.9mm),继而晒干,分装密封即可。
一种可有效治疗股骨头坏死的丸剂药物及其制备方法,其特征在于,所述服用方法为:将制备好的水丸剂药物以每日三次服用,早中晚各服一次,给药量9g /次,饭前1小时服(温开水送下),同时限制活动,经治疗80~170天后,获临床治愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
当归,性味:性温、味甘辛, 具有补血和血、调经止痛、润燥滑肠之功效,用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤等症;
三七,性味:甘、微苦、温,具有散瘀止血、消肿定痛之功效,用于治疗咯血、吐血、衄血、便血、崩漏、外伤出血、胸腹剌痛、跌扑肿痛等症;
川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛等症;
熟地黄,性味:甘、微温,具有滋阴补血、益精填髓之功效,用于治疗肝肾阴虚、腰膝酸软、骨蒸潮热、盗汗遗精、内热消渴、血虚萎黄、心悸怔忡、月经不调、崩漏下血、眩晕、耳鸣、须发早白;
人参,性味甘、微苦、平,具有大补元气、复脉固脱、补脾益肺、生津、安神之功效,用于治疗体虚欲脱、肢冷脉微、脾虚食少、肺虚喘咳、津伤口渴、内热消渴、久病虚羸、惊悸失眠、阳痿宫冷、心力衰竭、心原性休克等症;
赤芍,性味:苦、微寒,具有清热凉血、活血祛瘀之功效,用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤等症;
乳香(制),性味:辛、苦、温,具有活血行气止痛、消肿生肌之功效,用于治疗胸痹心痛、胃脘疼痛、痛经经闭、产后瘀阻、症瘕腹痛、风湿痹痛、筋脉拘挛、跌打损伤、痈肿疮疡等症;
黄芪,性味:甘、微温,具有补气固表、利尿托毒、排脓、敛疮生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病等症;
没药(制),性味:苦、平,具有散瘀止痛,外用消肿生肌之功效,用于治疗跌打淤血肿痛、痈疽肿痛、胸腹诸痛,外用治疮口久不收敛等症;
补骨脂(盐炙),性味:味辛、苦、性温,具有补肾助阳、纳气平喘、温脾止泻之功效,用于治疗肾阳不足、下元虚冷、腰膝冷痛、阳痿精、尿频;遗尿、肾不纳气、虚喘不止、脾肾两虚、大便久泻、白癜风、斑秃、银屑病等症;
骨碎补,性味:苦、性温,具有补肾强骨、活血止痛之功效,用于治疗肾虚腰痛、足膝痿弱、耳聋、牙痛、久泄、遗尿、跌打骨折及斑秃;
肉苁蓉,味辛、味甘、咸、性温,具有补肾阳、益精血、润肠道之功效,用于治疗肾阳虚衰、精血不足之阳痿、遗精、白浊、尿频余沥、腰痛脚弱、耳鸣目花、月经衍期、宫寒不孕、肠燥便秘;
仙灵脾,味辛:味辛、甘、性温,具有补肾壮阳、祛风除湿、强筋键骨之功效,用于治疗阳痿遗精、虚冷不育、尿频失楚、肾虚喘咳、腰膝酸软、风湿痹痛、半身不遂、四肢不仁;
土鳖虫(酒炙),性味:咸、寒,有小毒,具有活血散瘀、通经止痛之功效,用于治疗跌打损伤、淤血肿痛、闭经、产后瘀血腹痛等症;
全蝎,味辛、性平,有毒,具有祛风止痉、通络止痛、玫毒散结之功效,用于治疗小儿惊风、抽搐痉挛、中风口㖞、半身不遂、破伤风、风湿顽痹、偏正头痛、牙痛、耳聋、痈肿疮毒、瘰疬痰核、蛇咬伤、烧伤、风疹、顽癣、疮疡、瘰疬等症;
穿山甲(炮),性味:味咸、性微寒,具有活血散结、通经下乳、消痈溃坚之功效,用于治疗血瘀经闭、症瘕、风湿痹痛、乳汁不下、痈肿、瘰疬等症;
藏红花,性味:味甘、微辛、性平,具有活血祛瘀、散郁开结、凉血解毒之功效,用于治疗月经不调、痛经、经闭、产后恶露不行、腹中包块疼痛、跌扑损伤、忧郁痞闷、惊悸、温病发斑、麻疹等症;
鹿角胶,性味:味甘、咸、性温,具有补益精血、安胎止血之功效,用于治疗肾虚、精血不足、虚劳赢瘦、头晕耳鸣、腰膝酸软,阳痿滑精、宫寒不孕、胎动不安、崩漏带下、吐血、衄血、咯血、尿备、阴疽疮疡;
血竭,性味:味甘、咸、性平,有小毒,具有散瘀定痛、止血、生肌敛之功效,用于治疗跌打损伤、内伤瘀痛、痛经、产后瘀阻腹痛,外伤治出血不止、瘰疬、臁疮溃久不合及痔疮。
本发明药物是基于中医治疗股骨头坏死的辨病与辨证相结合的原则,从药理作用及作用机制认为:就股骨头坏死一证,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述股骨头坏死的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种可有效治疗股骨头坏死的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归13g、三七8g、川芎8g、熟地黄25g、人参8g、赤芍10g、乳香(制)13g、黄芪22g、没药(制) 15g、补骨脂(盐炙) 13g、骨碎补15g、肉苁蓉13g、仙灵脾8g、土鳖虫(酒炙)8g、全蝎4g、穿山甲(炮)13g、藏红花8g、鹿角胶8g、血竭1g。
实施例2:
一种可有效治疗股骨头坏死的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归14g、三七9g、川芎9g、熟地黄28g、人参9g、赤芍11g、乳香(制) 14g、黄芪25g、没药(制) 17g、补骨脂(盐炙) 14g、骨碎补17g、肉苁蓉14g、仙灵脾9g、土鳖虫(酒炙)9g、全蝎4.5g、穿山甲(炮)14g、藏红花9g、鹿角胶9g、血竭1.2g。
实施例3:
一种可有效治疗股骨头坏死的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归16g、三七10g、川芎10g、熟地黄32g、人参10g、赤芍12g、乳香(制) 16g、黄芪28g、没药(制) 20g、补骨脂(盐炙) 16g、骨碎补20g、肉苁蓉16g、仙灵脾10g、土鳖虫(酒炙)10g、全蝎5g、穿山甲(炮)16g、藏红花10g、鹿角胶10g、血竭1.5g。
典型病例:
经临床诊断治疗股骨头坏死患者共200例,年龄为47岁以上的135例,只有65例为47岁以下。200例患者中痊愈的185例,显效的15例,总有效率达100%。经治疗后,获临床治愈。
Claims (3)
1.一种可有效治疗股骨头坏死的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归8~16g、三七3~10g、川芎5~10g、熟地黄10~32g、人参3~10g、赤芍6~12g、乳香(制)5~16g、黄芪15~28g、没药(制) 5~20g、补骨脂(盐炙) 6~16g、骨碎补10~20g、肉苁蓉10~16g、仙灵脾3~10g、土鳖虫(酒炙)3~10g、全蝎2.5~5g、穿山甲(炮)8~16g、藏红花3~10g、鹿角胶3~10g、血竭0.5~1.5g。
2.根据权利要求1所述的可有效治疗股骨头坏死的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归10~14g、三七7~9g、川芎7~9g、熟地黄15~28g、人参7~9g、赤芍8~11g、乳香(制)10~14g、黄芪18~25g、没药(制) 12~17g、补骨脂(盐炙) 10~14g、骨碎补12~17g、肉苁蓉11~14g、仙灵脾7~9g、土鳖虫(酒炙)7~9g、全蝎3~4.5g、穿山甲(炮)10~14g、藏红花7~9g、鹿角胶7~9g、血竭0.8~1.2g。
3.根据权利要求1至2所述的可有效治疗股骨头坏死的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归13g、三七8g、川芎8g、熟地黄25g、人参8g、赤芍10g、乳香(制)13g、黄芪22g、没药(制) 15g、补骨脂(盐炙) 13g、骨碎补15g、肉苁蓉13g、仙灵脾8g、土鳖虫(酒炙)8g、全蝎4g、穿山甲(炮)13g、藏红花8g、鹿角胶8g、血竭1g。
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