CN106266312A - 一种治疗股骨头坏死的内服中药丸及其制备方法 - Google Patents

一种治疗股骨头坏死的内服中药丸及其制备方法 Download PDF

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CN106266312A
CN106266312A CN201610832148.0A CN201610832148A CN106266312A CN 106266312 A CN106266312 A CN 106266312A CN 201610832148 A CN201610832148 A CN 201610832148A CN 106266312 A CN106266312 A CN 106266312A
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罗兴贵
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Abstract

本发明属于中医药技术领域，目的是根据中医对股骨头坏死的认识机理而提供的一种治疗股骨头坏死的内服中药丸，所述中药丸的各个组分及其质量份比如下：人参、黄芪、西红花、川芎、红参、赤芍、防风、鸡血藤、川牛膝、熟地黄、桃仁、红花、三七、枸杞子、当归、熟附子、鹿角胶、麻黄、白芥子、淫羊藿、制川乌、制草乌、全蝎、蜈蚣、乳香(制)、西洋参、没药(制)、川楝子、自然铜、土鳖虫（酒炙）；本发明提供的药物是一个标本兼治的中药组方。

Description

一种治疗股骨头坏死的内服中药丸及其制备方法
技术领域
本发明涉及中医药技术领域，具体涉及一种治疗股骨头坏死的内服中药丸，特别是供股骨头坏死患者使用的内服中药丸及其制备方法的领域。
背景技术
股骨头坏死是一个病理演变过程，初始发生在股骨头的负重区，应力作用下坏死骨骨小梁结构发生损伤即显微骨折以及随后针对损伤骨组织的修复过程。造成骨坏死的原因不消除，修复不完善，损伤-修复的过程继续，导致股骨头结构改变、股骨头塌陷、变形，关节炎症，功能障碍。股骨头坏死固然会引起病痛，关节活动和负重行走功能障碍，但人们不要受“坏和死”文字含义恐怖的影响，股骨头坏死病变，毕竟局限，累及个别关节，可以减轻，消退和自愈，即便严重，最后还可以通过人工髋关节置换补救，仍能恢复步行能力。
那么，就如何找到一种可有效治疗上述股骨头坏死的药物，是我们目前急需要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗股骨头坏死上，人们逐渐意识到了中医治疗上述股骨头坏死的优点，且在治疗过程中毒副作用小、费用低等优势，针对现有西医治疗上述股骨头坏死的现状，本发明的目的是在于提供一种治疗股骨头坏死的内服中药丸，以解决股骨头坏死患者早日恢复健康的问题。该药物是以常见的中药为原料，具有见效快、疗效显著等特点，并可有效治疗上述股骨头坏死。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗股骨头坏死的内服中药丸及其制备方法，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参3～10g、黄芪9～30g、西红花3～12g、川芎5～12g、红参3～12g、赤芍6～12g、防风5～12g、鸡血藤15～25g、川牛膝8～16g、熟地黄12～32g、桃仁8～16g、红花5～12g、三七3～12g、枸杞子10～20g、当归8～16g、熟附子3～9g、 鹿角胶3～10g、麻黄2.5～10g、白芥子3～12g、淫羊藿3～10g、制川乌1.5～3g、制草乌1.5～3g、全蝎2.5～5g、蜈蚣2.5～5g、乳香(制)3～5g、西洋参3～6g、没药(制) 5～20g、川楝子3～10g、自然铜5～15g、土鳖虫（酒炙）3～9g。
一种治疗股骨头坏死的内服中药丸及其制备方法，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参7～9g、黄芪15～26g、西红花8～11g、川芎7～11g、红参8～11g、赤芍8～11g、防风8～11g、鸡血藤18～22g、川牛膝10～14g、熟地黄15～28g、桃仁10～14g、红花8～11g、三七8～11g、枸杞子12～17g、当归10～14g、熟附子7～8g、 鹿角胶7～9g、麻黄6～9g、白芥子8～11g、淫羊藿7～9g、制川乌2～2.5g、制草乌2～2.5g、全蝎3～4.5g、蜈蚣3～4.5g、乳香(制)3.5～4.5g、西洋参4～5.5g、没药(制) 12～17g、川楝子7～9g、自然铜10～13g、土鳖虫（酒炙）7～8g。
一种治疗股骨头坏死的内服中药丸及其制备方法，其特征在于，所述“最佳方案”的中药丸的各个组分及其质量份比如下所示：
人参8g、黄芪23g、西红花10g、川芎10g、红参10g、赤芍10g、防风10g、鸡血藤20g、川牛膝13g、熟地黄25g、桃仁13g、红花10g、三七10g、枸杞子15g、当归13g、熟附子7g、鹿角胶8g、麻黄8g、白芥子10g、淫羊藿10g、制川乌2g、制草乌2g、全蝎4g、蜈蚣4g、乳香(制) 4g、西洋参5g、没药(制) 15g、川楝子8g、自然铜12g、土鳖虫（酒炙）7.5g。
一种治疗股骨头坏死的内服中药丸及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比共研为极细末待用；
B、按照传统制备中药水丸剂的方法，将研磨好的极细末药物过筛后，放入药器中混合拌均，然后制备成水丸剂（其水丸的粒度为：4.7mm-5.0mm），进而晒干，分装密封即可。
一种治疗股骨头坏死的内服中药丸及其制备方法，其特征在于，所述服用方法为：将制备好的水丸剂药物以每日三次服用，早中晚各服一次，给药量7g /次，饭前1小时服，同时限制活动，经治疗90～180天后，获临床治愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
人参，性味甘、微苦、平，具有大补元气、复脉固脱、补脾益肺、生津、安神之功效，用于治疗体虚欲脱、肢冷脉微、脾虚食少、肺虚喘咳、津伤口渴、内热消渴、久病虚羸、惊悸失眠、阳痿宫冷、心力衰竭、心原性休克等症；
黄芪，性味：甘、微温，具有补气固表、利尿托毒、排脓、敛疮生肌之功效，用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病等症；
西红花，性味：甘、平，具有活血化瘀、凉血解毒、解郁安神之功效，用于治疗经闭症瘕、产后瘀阻、温毒发斑、忧郁痞闷、惊悸发狂等症；
川芎，性味：辛、温，具有行气开郁、法风燥湿、活血止痛之功效，用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛等症；
红参，性味：甘、微苦、温，具有大补元气、复脉固脱、益气摄血之功效，用于治疗体虚欲脱、肢冷脉微、气不摄血、崩漏下血、心力衰竭、心原性休克；
赤芍，性味：苦、微寒，具有清热凉血、活血祛瘀之功效，用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤等症；
防风，性味：味辛、甘、性微温，具有祛风解表、胜湿止痛、止痉定搐的功效，用于治疗外感表证、风疹瘙痒、风湿痹痛、破伤风等病症；
鸡血藤，性味：味苦、微甘、性温，具有活血舒筋、养血调经之功效，用于治疗手足麻木、肢体瘫痪、风湿痹痛、妇女有经不调、痛经、闭经等症；
川牛膝，性味：甘、微苦、性平，具有活血祛瘀、祛风利湿之功效，用于治疗血瘀经闭、难产、胞衣不下、产后瘀血腹痛、热淋、石淋、痛经、风湿腰膝疼痛等症；
熟地黄，性味：甘、微温，具有滋阴补血、益精填髓之功效，用于治疗肝肾阴虚、腰膝酸软、骨蒸潮热、盗汗遗精、内热消渴、血虚萎黄、心悸怔忡、月经不调、崩漏下血、眩晕、耳鸣、须发早白；
桃仁，性味：苦甘、平，具有破血行瘀、润燥滑肠之功效，用于治疗经闭、症瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘等症；
红花，性味：味辛、性温，具有活血能经、祛瘀止痛之功效，用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症；
三七，性味：甘、微苦、温，具有散瘀止血、消肿定痛之功效，用于治疗咯血、吐血、衄血、便血、崩漏、外伤出血、胸腹剌痛、跌扑肿痛等症；
枸杞子，性味：味甘、性平，具有养肝、滋肾、润肺之功效，用于治疗肝肾亏虚、头晕目眩、目视一清、腰膝酸软、阳痿贵精、虚劳咳嗽、消渴引饮等症；
当归，性味：性温、味甘辛, 具有补血和血、调经止痛、润燥滑肠之功效，用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤等症；
熟附子，性味：辛甘、热，有毒，具有回阳救逆、补火助阳、散寒除湿之功效，用于治疗阴盛格阳、大汗亡阳、吐利厥逆、心腹冷痛、脾泄冷痢、脚气水肿小儿慢惊、风寒湿痹、踒躄拘挛、阳萎、宫冷阴、疽疮漏及一切沉寒痼冷之疾；
鹿角胶，性味：味甘、咸、性温，具有补益精血、安胎止血之功效，用于治疗肾虚、精血不足、虚劳赢瘦、头晕耳鸣、腰膝酸软、阳痿滑精、宫寒不孕、胎动不安、崩漏带下、吐血、衄血、咯血、尿备、阴疽疮疡；
麻黄，性味：辛苦、温，具有发汗、平喘、利水之功效，用于治疗伤寒表实、发热恶寒无汗、头痛鼻塞、骨节疼痛、咳嗽气喘、风水浮肿、小便不利、风邪顽痹、皮肤不仁、风疹瘙痒等症；
白芥子，性味：辛、温，具有化痰逐饮、散结消肿之功效，用于治疗咳喘痰多、胸满胁痛、肢体麻木、关节肿痛、湿痰流注、阴疽肿毒；
淫羊藿，性味：味辛、味辛、甘、性温，具有补肾壮阳、祛风除湿、强筋键骨之功效，用于治疗阳痿遗精、虚冷不育、尿频失楚、肾虚喘咳、腰膝酸软、风湿痹痛、半身不遂、四肢不仁；
制川乌，性味：辛、苦、热，有毒，具有祛风除湿、温经止痛之功效，用于治疗风寒湿痹、关节疼痛、心腹冷痛、寒疝作痛、麻醉止痛；
制草乌，性味：辛、苦、热，有毒，具有祛风除湿，温经止痛之功效，用于治疗风寒湿痹、关节疼痛、心腹冷痛、寒疝作痛、麻醉止痛；
全蝎，味辛、性平，有毒，具有祛风止痉、通络止痛、玫毒散结之功效，用于治疗小儿惊风、抽搐痉挛、中风口㖞、半身不遂、破伤风、风湿顽痹、偏正头痛、牙痛、耳聋、痈肿疮毒、瘰疬痰核、蛇咬伤、烧伤、风疹、顽癣、疮疡、瘰疬等症；
蜈蚣，性味：味辛、性温，有毒，具有祛风止痉、通络止痛、攻毒散结之功效，用于治疗惊风、癫痫、痉挛抽搐、中风口、破伤风、风湿顽痹、偏正头痛、毒蛇咬伤、疮疡、瘰疬等症；
乳香(制)，性味：辛、苦、温，具有活血行气止痛、消肿生肌之功效，用于治疗胸痹心痛、胃脘疼痛、痛经经闭、产后瘀阻、症瘕腹痛、风湿痹痛、筋脉拘挛、跌打损伤、痈肿疮疡等症；
西洋参，性味：味甘、微苦、性寒, 具有补气养阴、清火生津之功效，用于治疗虚阴专火旺、咳嗽痰血、虚热烦烦倦、内热消渴、口燥烟干；
没药(制)，性味：苦、平，具有散瘀止痛，外用消肿生肌之功效，用于治疗跌打淤血肿痛、痈疽肿痛、胸腹诸痛，外用治疮口久不收敛等症；
川楝子，性味：苦、寒，有小毒，具有疏肝泄热、行气止痛、杀虫之功效，用于治疗脘腹胁肋疼痛、疝气疼痛、虫积腹痛、头癣；
自然铜，性味：辛；苦、平，无毒，具有散瘀止痛、接骨续筋之功效，用于治疗跌打损伤、筋断骨折、瘀滞肿痛；
土鳖虫（酒炙），性味：咸、寒，有小毒，具有活血散瘀、通经止痛之功效，用于治疗跌打损伤、淤血肿痛、闭经、产后瘀血腹痛等症。
本发明药物是基于中医治疗股骨头坏死的辨病与辨证相结合的原则，从药理作用及作用机制认为：就股骨头坏死一证，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述股骨头坏死的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗股骨头坏死的内服中药丸，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参8g、黄芪23g、西红花10g、川芎10g、红参10g、赤芍10g、防风10g、鸡血藤20g、川牛膝13g、熟地黄25g、桃仁13g、红花10g、三七10g、枸杞子15g、当归13g、熟附子7g、 鹿角胶8g、麻黄8g、白芥子10g、淫羊藿10g、制川乌2g、制草乌2g、全蝎4g、蜈蚣4g、乳香(制) 4g、西洋参5g、没药(制) 15g、川楝子8g、自然铜12g、土鳖虫（酒炙）7.5g。
实施例2：
一种治疗股骨头坏死的内服中药丸，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参9g、黄芪26g、西红花11g、川芎11g、红参11g、赤芍11g、防风11g、鸡血藤22g、川牛膝14g、熟地黄28g、桃仁14g、红花11g、三七11g、枸杞子17g、当归14g、熟附子8g、 鹿角胶9g、麻黄9g、白芥子11g、淫羊藿9g、制川乌2.5g、制草乌2.5g、全蝎4.5g、蜈蚣4.5g、乳香(制)4.5g、西洋参5.5g、没药(制) 17g、川楝子9g、自然铜13g、土鳖虫（酒炙）8g。
实施例3：
一种治疗股骨头坏死的内服中药丸，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参10g、黄芪30g、西红花12g、川芎12g、红参12g、赤芍12g、防风12g、鸡血藤25g、川牛膝16g、熟地黄32g、桃仁16g、红花12g、三七12g、枸杞子20g、当归16g、熟附子9g、 鹿角胶10g、麻黄10g、白芥子12g、淫羊藿10g、制川乌3g、制草乌3g、全蝎5g、蜈蚣5g、乳香(制) 5g、西洋参6g、没药(制) 20g、川楝子10g、自然铜15g、土鳖虫（酒炙）9g。
典型病例：
经临床诊断治疗股骨头坏死患者共220例，年龄为43岁以上的145例，只有75例为43岁以下。220例患者中痊愈的185例，显效的35例，总有效率达100%。经治疗后，获临床治愈。

Claims (3)

1.一种治疗股骨头坏死的内服中药丸，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参3～10g、黄芪9～30g、西红花3～12g、川芎5～12g、红参3～12g、赤芍6～12g、防风5～12g、鸡血藤15～25g、川牛膝8～16g、熟地黄12～32g、桃仁8～16g、红花5～12g、三七3～12g、枸杞子10～20g、当归8～16g、熟附子3～9g、 鹿角胶3～10g、麻黄2.5～10g、白芥子3～12g、淫羊藿3～10g、制川乌1.5～3g、制草乌1.5～3g、全蝎2.5～5g、蜈蚣2.5～5g、乳香(制)3～5g、西洋参3～6g、没药(制) 5～20g、川楝子3～10g、自然铜5～15g、土鳖虫（酒炙）3～9g。
2.根据权利要求1所述的治疗股骨头坏死的内服中药丸，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参7～9g、黄芪15～26g、西红花8～11g、川芎7～11g、红参8～11g、赤芍8～11g、防风8～11g、鸡血藤18～22g、川牛膝10～14g、熟地黄15～28g、桃仁10～14g、红花8～11g、三七8～11g、枸杞子12～17g、当归10～14g、熟附子7～8g、 鹿角胶7～9g、麻黄6～9g、白芥子8～11g、淫羊藿7～9g、制川乌2～2.5g、制草乌2～2.5g、全蝎3～4.5g、蜈蚣3～4.5g、乳香(制)3.5～4.5g、西洋参4～5.5g、没药(制) 12～17g、川楝子7～9g、自然铜10～13g、土鳖虫（酒炙）7～8g。
3.根据权利要求1至2所述的治疗股骨头坏死的内服中药丸，其特征在于，所述中药丸的各个组分及其质量份比如下所示：
人参8g、黄芪23g、西红花10g、川芎10g、红参10g、赤芍10g、防风10g、鸡血藤20g、川牛膝13g、熟地黄25g、桃仁13g、红花10g、三七10g、枸杞子15g、当归13g、熟附子7g、鹿角胶8g、麻黄8g、白芥子10g、淫羊藿10g、制川乌2g、制草乌2g、全蝎4g、蜈蚣4g、乳香(制) 4g、西洋参5g、没药(制) 15g、川楝子8g、自然铜12g、土鳖虫（酒炙）7.5g。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108404038A (zh) * 2017-02-09 2018-08-17 林峰 一种治疗股骨头缺血性坏死的温阳化浊通脉活骨中药组合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108404038A (zh) * 2017-02-09 2018-08-17 林峰 一种治疗股骨头缺血性坏死的温阳化浊通脉活骨中药组合物
CN108404038B (zh) * 2017-02-09 2020-12-29 林畅 一种治疗股骨头缺血性坏死的温阳化浊通脉活骨中药组合物

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