CN106265278A - Infant buttocks-care cream and preparation method thereof - Google Patents
Infant buttocks-care cream and preparation method thereof Download PDFInfo
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- CN106265278A CN106265278A CN201610768986.6A CN201610768986A CN106265278A CN 106265278 A CN106265278 A CN 106265278A CN 201610768986 A CN201610768986 A CN 201610768986A CN 106265278 A CN106265278 A CN 106265278A
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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Abstract
The present invention relates to a kind of skin care applications, particularly to a kind of infant buttocks-care cream and preparation method thereof.Infant buttocks-care cream includes following weight parts component: isolated form oils and fats 5 30 parts, thickening agent 1 10 parts, stabilizer 2 10 parts, releiving composition 5 20 parts, skin moistening nourishes composition 5 30 parts, 50 80 parts of water, wherein, the described mixture that isolated form oils and fats is vaseline and lanoline；Stabilizer is lanolin alcohol；Composition of releiving is Butyrospermum parkii fruit fat, Fructus oleae europaeae fruit oil, bisabolol and the mixture of ginger-root extract；Skin moistening nourishes the mixture that composition is tocopherol acetas and pantothenylol.The present invention is Water-In-Oil cream shape, utilizes isolation enclosed type material to form certain thickness physics water proof air-permeable layer on skin, can completely cut off urine, dampness and physical property friction, reduces diaper rash and occur；Utilization is releived type natural plant composition, the sense of discomfort that skin is caused by environmental stimuli of releiving；Pantothenylol is utilized to help the healing of impaired skin.
Description
Technical field
The present invention relates to a kind of skin care applications, particularly to a kind of infant buttocks-care cream and preparation method thereof.
Background technology
" diaper rash ", is commonly called as " red hip " (i.e. diaper dermatitis, department of pediatrics name of disease), is dermatosis common in baby, occurs at treasured
Treasured is wrapped up in the finger at diaper position and is betided limitation lamellar erythema or the disease of unboiled water bubble at baby diaper encapsulation position, is a seed coat
Skin inflammatory lesion, for the scytitis that ewborn infant is common, how because of the body of children's's heat in blood, skin and flesh is tender and lovely, and wet diaper impregnated
For a long time, damp and hot gas is handed over and is steamed, and causes skin buttocks of falling into oblivion and forms.
Primary disease is more common in baby, and in diaper covering part, such as perineum, scrotum, femoribus internus, buttocks etc., nascent can
See lamellar erythema, match with diaper area coverage that clear-cut margin, because of urine insult, erythema also can be given birth to vesicle, or rotten
Rotten, sepage, with the passing of time erythema are dried, and decortication, pachylosis, baby is not relaxed because of affected part often humidity, therefore it is noisy easily to cry.Diaper dermatitis shows
Symptom is skin rubefaction, and skin has the mottled measles of redness, broken skin, even festers flowing water.When diaper dermatitis starts, at every side buttocks
Center, portion can find two pieces " kermes sample blush "；Pimple occurs then, erosion, damaged phenomenon occur slowly；Skin time serious
Skin can occur erosion, ulcer, even can cause the concurrent of septicemia.
And be of rude workmanship due to diaper on existing market, raw material is defective, underproof raw material or produce storage
During Tibetan, raw material is polluted by chemistry, physics, biology, and infant skin children is tender, horny layer is belittled, and makes for a long time
With these matter materials inferior diaper, infant skin had bad stimulation, thus cause redness, foaming, erosion, ooze out
The reaction of Lymph nodes and allergy causes baby's diaper dermatitis.
Therefore the use of stern protection cream has market prospect widely, the stern protection cream in currently available technology be mainly waterproof every
From method, focus on water-proof function, only can completely cut off dampness for infant skin skin surface, but red to the skin occurred
Swollen etc. do not have specific aim measure.
Summary of the invention
It is an object of the invention to overcome defect of the prior art, it is provided that a kind of Water-In-Oil cream shape, not only can completely cut off
Urine, dampness and physical property friction, reduce diaper rash and occur, the sense of discomfort that skin is caused by environmental stimuli of releiving；Simultaneously can
Maintenance, the infant buttocks-care cream nourishing the healing of impaired skin and preparation method thereof.
For realizing the purpose of the present invention, the scheme used:
A kind of infant buttocks-care cream, including following weight parts component:
Wherein, the described mixture that isolated form oils and fats is vaseline and lanoline；Stabilizer is lanolin alcohol；Releive into
It is divided into Butyrospermum parkii fruit fat, Fructus oleae europaeae fruit oil, bisabolol and the mixture of ginger-root extract；Skin moistening nourishes composition for fertility
Phenol acetas and the mixture of pantothenylol.
Described skin moistening nourishes composition and also includes allantoin, cetearyl alcohol ethylhexoate and the one of tribehenin essence
Or several mixture.
Preferred, including following weight parts component as one therein:
Preferred as one therein, infant buttocks-care cream includes following weight parts component:
Isolated form oils and fats: 9 parts of vaseline, lanoline 5 parts；
Thickening agent: 1 part of Cera Flava, cetearyl alcohol 1 part；
Stabilizer: lanolin alcohol 5 parts；
Releive composition: Butyrospermum parkii fruit 9 parts of fat, Fructus oleae europaeae fruit oil 2 parts, bisabolol 0.2 part, ginger-root extract 0.001
Part；
Skin moistening nourishing composition: tocopherol acetas 0.1 part, pantothenylol 5 parts, cetearyl alcohol ethylhexoate 8 parts；
Water: 55 parts.
Present invention additionally comprises a kind of method preparing described infant buttocks-care cream, comprise the steps:
1): by isolated form oils and fats, thickening agent, stabilizer and composition mixing post-heating of releiving to 70-75 DEG C, stirring and dissolving
Oil phase component A is obtained standby after Wan Quan；
When containing other oil-soluble ingredients in addition to tocopherol acetas during skin moistening nourishes composition, then by this oil-soluble ingredients
Being heated to 70-75 DEG C, stirring and dissolving is complete, obtains oil phase B component standby；
2): the water soluble ingredient nourished by skin moistening in composition is added to the water mix homogeneously, is heated to 70-75 DEG C, stir molten
Solve completely, obtain water-phase component standby；
3): under vacuum homogenizing stirs, by step 2) water-phase component that obtains is dividedly in some parts step 1) the oil phase group that obtains
In Fen, homogenous disperse is uniform；Stirring is cooled to 45 DEG C-50 DEG C, adds tocopherol acetas, and dispersed with stirring is uniform；Continue stirring
It is cooled to room temperature, i.e. can get product of the present invention；
When not containing other oil-soluble ingredients in addition to tocopherol acetas during skin moistening nourishes composition, described oil phase component
For oil phase component A；When containing other oil-soluble ingredients in addition to tocopherol acetas during skin moistening nourishes composition, described oil phase group
It is divided into the mixture of oil phase component A and oil phase B component.
Compared with prior art, the invention has the beneficial effects as follows:
The dosage form that the present invention uses is Water-In-Oil cream shape, utilizes isolated form oils and fats to form certain thickness thing on skin
Reason water proof air-permeable layer, can completely cut off urine, dampness and physical property friction, reduces diaper rash and occurs；Meanwhile, utilization is releived, and type is natural plants
Thing composition Butyrospermum parkii fruit fat, Fructus oleae europaeae fruit oil, bisabolol and the mixture of ginger-root extract, environmental stimuli of releiving is to skin
The sense of discomfort that skin causes.Utilize tocopherol acetas can help the healing of impaired skin by Glycerin with the mixture of pantothenylol.Thus,
Product of the present invention has and has dual function, has both been possible to prevent diaper rash, and diaper rash can be helped again to recover.The present invention compares tradition
For technology, there is the simple feature of safety, high efficiency, and preparation method simultaneously.
Detailed description of the invention
Below in conjunction with embodiment, this formula is further described:
Embodiment 1
By isolated form oils and fats: vaseline 9kg, lanoline 5kg；Thickening agent: Cera Flava 1kg, cetearyl alcohol 1kg；Stabilizer:
Lanolin alcohol 5kg；Releive composition: Butyrospermum parkii fruit fat 9kg, Fructus oleae europaeae fruit oil 2kg, bisabolol 0.2kg, ginger-root extract
0.001kg mixing post-heating, to 70 DEG C, obtains oil phase component A after stirring and dissolving is complete standby；Skin moistening is nourished spermaceti in composition
Stearyl alcohol ethylhexoate 8kg is heated to 75 DEG C, obtains oil phase B component standby after stirring and dissolving is complete；Pantothenylol 5kg is added water
Mix homogeneously in 55kg, is heated to 75 DEG C, and stirring and dissolving is complete, obtains water-phase component standby；Under vacuum homogenizing stirs, by water
Phase constituent is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues stirring cooling 45 DEG C, adds raw
Educating phenol acetas 0.1kg, dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get product of the present invention.
Embodiment 2
By isolated form oils and fats: vaseline 3kg, lanoline 2kg；Thickening agent: Cera Flava 0.5kg, cetearyl alcohol 0.5kg；Surely
Determine agent: lanolin alcohol 2kg；Releive composition: Butyrospermum parkii fruit fat 2kg, Fructus oleae europaeae fruit oil 2.5kg, bisabolol 0.4kg, race
Extract 0.001kg, Aloe extract 0.1kg mixing post-heating, to 72 DEG C, obtain oil phase component A after stirring and dissolving is complete standby
With；Pantothenylol 4.5kg being added mix homogeneously in water 50kg, is heated to 72 DEG C, stirring and dissolving is complete, obtains water-phase component standby；
Under vacuum homogenizing stirs, water-phase component is dividedly in some parts oil phase component A, after being uniformly dispersed, continues stirring cooling 45 DEG C, add
Tocopherol acetas 0.5kg, dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get product of the present invention.
Embodiment 3
By isolated form oils and fats: vaseline 5kg, lanoline 5kg；Thickening agent: Cera Flava 5kg, cetearyl alcohol 5kg；Stabilizer:
Lanolin alcohol 10kg；Releive composition: Butyrospermum parkii fruit fat 15kg, Fructus oleae europaeae fruit oil 4kg, bisabolol 0.2kg, ginger-root extract
0.001kg mixing post-heating, to 75 DEG C, obtains oil phase component A after stirring and dissolving is complete standby；Pantothenylol 12kg is added water 80kg
Middle mix homogeneously, is heated to 70 DEG C, and stirring and dissolving is complete, obtains water-phase component standby；Under vacuum homogenizing stirs, aqueous phase is become
It is divided into and being dividedly in some parts in oil phase component A, after being uniformly dispersed, continue stirring cooling 45 DEG C, add tocopherol acetas 2kg, stirring
It is uniformly dispersed；Continue stirring and be cooled to room temperature, i.e. can get product of the present invention.
Embodiment 4
By isolated form oils and fats: vaseline 5kg, lanoline 5kg, polydimethylsiloxane 2kg；Thickening agent: Cera Flava 1kg, whale
Wax stearyl alcohol 1kg；Stabilizer: lanolin alcohol 4kg；Releive composition: Butyrospermum parkii fruit fat: 7kg, Fructus oleae europaeae fruit oil 2kg, opopanax
Alcohol 0.2kg, ginger-root extract 0.001kg mixing post-heating, to 73 DEG C, obtain oil phase component A after stirring and dissolving is complete standby；Will
Skin moistening nourishes cetearyl alcohol ethylhexoate 3kg in composition and is heated to 73 DEG C, obtains oil phase B component standby after stirring and dissolving is complete
With；Pantothenylol 5kg being added mix homogeneously in water 50kg, is heated to 73 DEG C, stirring and dissolving is complete, obtains water-phase component standby；?
Under the stirring of vacuum homogenizing, water-phase component is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues
Stirring cooling 45 DEG C, adds tocopherol acetas 2kg, and dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get this
Bright product.
Embodiment 5
By isolated form oils and fats: vaseline 10kg, lanoline 8kg, polydimethylsiloxane 2kg；Thickening agent: Cera Flava 2kg, whale
Wax stearyl alcohol 3kg；Stabilizer: lanolin alcohol 6kg；Releive composition: Butyrospermum parkii fruit fat: 10kg, Fructus oleae europaeae fruit oil 4kg, red do not have
Medicine alcohol 0.9kg, ginger-root extract 0.001kg mixing post-heating, to 75 DEG C, obtain oil phase component A after stirring and dissolving is complete standby；
Skin moistening is nourished cetearyl alcohol ethylhexoate 8kg in composition and is heated to 75 DEG C, after stirring and dissolving is complete, obtain oil phase B component
Standby；Pantothenylol 5kg being added mix homogeneously in water 70kg, is heated to 75 DEG C, stirring and dissolving is complete, obtains water-phase component standby；
Under vacuum homogenizing stirs, water-phase component is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues
Continuous stirring cooling 45 DEG C, adds tocopherol acetas 2kg, and dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get this
Invention product.
Embodiment 6
By isolated form oils and fats: vaseline 10kg, lanoline 8kg, polydimethylsiloxane 2kg；Thickening agent: Cera Flava 2kg, whale
Wax stearyl alcohol 3kg；Stabilizer: lanolin alcohol 6kg；Releive composition: Butyrospermum parkii fruit fat: 8kg, Fructus oleae europaeae fruit oil 6kg, opopanax
Alcohol 0.5kg, ginger-root extract 0.001kg mixing post-heating, to 75 DEG C, obtain oil phase component A after stirring and dissolving is complete standby；Will
Skin moistening nourishes cetearyl alcohol ethylhexoate 8kg in composition and is heated to 70 DEG C, obtains oil phase B component standby after stirring and dissolving is complete
With；Pantothenylol 5kg being added mix homogeneously in water 70kg, is heated to 70 DEG C, stirring and dissolving is complete, obtains water-phase component standby；?
Under the stirring of vacuum homogenizing, water-phase component is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues
Stirring cooling 50 DEG C, adds tocopherol acetas 2kg, and dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get this
Bright product.
Embodiment 7
By isolated form oils and fats: vaseline 8kg, lanoline 8kg；Thickening agent: Cera Flava 2kg, cetearyl alcohol 3kg；Stabilizer:
Lanolin alcohol 4kg；Releive composition: Butyrospermum parkii fruit fat: 10kg, Fructus oleae europaeae fruit oil 4kg, bisabolol 0.2kg, ginger-root extract
0.01kg mixing post-heating, to 72 DEG C, obtains oil phase component A after stirring and dissolving is complete standby；Skin moistening is nourished tribehenin in composition
Essence 2kg is heated to 72 DEG C, obtains oil phase B component standby after stirring and dissolving is complete；Pantothenylol 5kg, allantoin 2kg are added water 70kg
Middle mix homogeneously, is heated to 72 DEG C, and stirring and dissolving is complete, obtains water-phase component standby；Under vacuum homogenizing stirs, aqueous phase is become
It is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues stirring cooling 47 DEG C, add tocopherol
Acetas 2kg, dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get product of the present invention.
Embodiment 8
By isolated form oils and fats: vaseline 10kg, lanoline 8kg, polydimethylsiloxane 2kg；Thickening agent: Cera Flava 7kg, whale
Wax stearyl alcohol 3kg；Stabilizer: lanolin alcohol 8kg；Releive composition: Butyrospermum parkii fruit fat: 10kg, Fructus oleae europaeae fruit oil 4kg, red do not have
Medicine alcohol 0.2kg, ginger-root extract 0.01kg mixing post-heating, to 70 DEG C, obtain oil phase component A after stirring and dissolving is complete standby；Will
Skin moistening nourishes tribehenin essence 2kg in composition and is heated to 70 DEG C, obtains oil phase B component standby after stirring and dissolving is complete；By pantothenylol
5kg, allantoin 2kg add mix homogeneously in water 70kg, are heated to 70 DEG C, and stirring and dissolving is complete, obtains water-phase component standby；?
Under the stirring of vacuum homogenizing, water-phase component is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues
Stirring cooling 50 DEG C, adds tocopherol acetas 2kg, and dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get this
Bright product.
Embodiment 9
By isolated form oils and fats: vaseline 10kg, lanoline 4kg, polydimethylsiloxane 2kg；Thickening agent: Cera Flava 2kg, whale
Wax stearyl alcohol 3kg；Stabilizer: lanolin alcohol 6kg；Releive composition: Butyrospermum parkii fruit fat: 10kg, Fructus oleae europaeae fruit oil 4kg, red do not have
Medicine alcohol 0.2kg, ginger-root extract 0.01kg mixing post-heating, to 70 DEG C, obtain oil phase component A after stirring and dissolving is complete standby；Will
Skin moistening nourishes cetearyl alcohol ethylhexoate 8kg in composition and is heated to 70 DEG C, obtains oil phase B component standby after stirring and dissolving is complete
With；Pantothenylol 5kg, allantoin 2kg being added mix homogeneously in water 60kg, is heated to 75 DEG C, stirring and dissolving is complete, obtains aqueous phase
Divide standby；Under vacuum homogenizing stirs, water-phase component being dividedly in some parts the mixture of oil phase component A and oil phase B component, dispersion is all
After even, continuing stirring cooling 45 DEG C, add tocopherol acetas 2kg, dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e.
Available product of the present invention.
Embodiment 10
By isolated form oils and fats: vaseline 12kg, lanoline 8kg, polydimethylsiloxane 2kg；Thickening agent: Cera Flava 2kg, whale
Wax stearyl alcohol 3kg；Stabilizer: lanolin alcohol 6kg；Releive composition: Butyrospermum parkii fruit fat: 10kg, Fructus oleae europaeae fruit oil 4kg, red do not have
Medicine alcohol 0.2kg, ginger-root extract 0.01kg mixing post-heating, to 70 DEG C, obtain oil phase component A after stirring and dissolving is complete standby；Will
Skin moistening nourishes tribehenin essence 2kg in composition and is heated to 70 DEG C, obtains oil phase B component standby after stirring and dissolving is complete；By pantothenylol 5kg
Adding mix homogeneously in water 80kg, be heated to 70 DEG C, stirring and dissolving is complete, obtains water-phase component standby；Stir at vacuum homogenizing
Under, water-phase component is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues stirring cooling 45
DEG C, adding tocopherol acetas 2kg, dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get product of the present invention.
Embodiment 11
By isolated form oils and fats: vaseline 12kg, lanoline 8kg；Thickening agent: Cera Flava 2kg, cetearyl alcohol 3kg；Stable
Agent: lanolin alcohol 6kg；Releive composition: Butyrospermum parkii fruit fat: 5kg, Fructus oleae europaeae fruit oil 4kg, bisabolol 0.2kg, race extract
Thing 0.01kg mixing post-heating, to 70 DEG C, obtains oil phase component A after stirring and dissolving is complete standby；Skin moistening is nourished three mountain in composition
Yu essence 2kg, cetearyl alcohol ethylhexoate 4kg are heated to 70 DEG C, obtain oil phase B component standby after stirring and dissolving is complete；Will
Pantothenylol 2kg adds mix homogeneously in water 60kg, is heated to 70 DEG C, and stirring and dissolving is complete, obtains water-phase component standby；Equal in vacuum
Under matter stirring, water-phase component is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues stirring fall
Temperature 45 DEG C, adds tocopherol acetas 2kg, and dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get the present invention and produce
Product.
Embodiment 12
By isolated form oils and fats: vaseline 12kg, lanoline 8kg；Thickening agent: Cera Flava 2kg, cetearyl alcohol 3kg；Stable
Agent: lanolin alcohol 4kg；Releive composition: Butyrospermum parkii fruit fat: 5kg, Fructus oleae europaeae fruit oil 4kg, bisabolol 0.2kg, race extract
Thing 0.01kg mixing post-heating, to 70 DEG C, obtains oil phase component A after stirring and dissolving is complete standby；Skin moistening is nourished spermaceti in composition
Stearyl alcohol ethylhexoate 4kg, tribehenin essence 2kg are heated to 70 DEG C, obtain oil phase B component standby after stirring and dissolving is complete；Will
Pantothenylol 5kg adds mix homogeneously in water 60kg, is heated to 75 DEG C, and stirring and dissolving is complete, obtains water-phase component standby；Equal in vacuum
Under matter stirring, water-phase component is dividedly in some parts the mixture of oil phase component A and oil phase B component, after being uniformly dispersed, continues stirring fall
Temperature 45 DEG C, adds tocopherol acetas 2kg, and dispersed with stirring is uniform；Continue stirring and be cooled to room temperature, i.e. can get the present invention and produce
Product.
Embodiment 1-12 all can meet the enforcement purpose of the present invention, and the result of embodiment 1 is optimum, as a example by embodiment 1, and merit
Can test and result is as follows.
Experiment one: heavy metal and microorganism detection experiment.
1. detection project: lead, hydrargyrum, arsenic, total plate count, yeast and mold sum, excrement colibacillus group, Staphylococcus aureus
Bacterium, Pseudomonas aeruginosa.
2. detection foundation: QB/T 1857-2013 skin moistening cream (water-in-oil type).
3. testing result is as shown in table 1: institute's detection project meets the regulation of QB/T 1857-2013 standard.
Table 1
| Inspection project | Unit | Standard-required | Testing result | Individual event judges |
| Lead | mg/kg | ≤40 | <1.5 | Qualified |
| Hydrargyrum | mg/kg | ≤1 | 0.01 | Qualified |
| Arsenic | mg/kg | ≤10 | <0.01 | Qualified |
| Total plate count | CFU/g | ≤1000 | <10 | Qualified |
| Yeast and mold sum | CFU/g | ≤100 | <10 | Qualified |
| Excrement colibacillus group/g | ------ | Must not detect | Do not detect | Qualified |
| Staphylococcus aureus/g | ------ | Must not detect | Do not detect | Qualified |
| Pseudomonas aeruginosa/g | ------ | Must not detect | Do not detect | Qualified |
4. test result: product of the present invention does not exist heavy metal risk, safety is high.
Experiment two: skin irritation/corrosion test (repeatedly skin irritation test).
1. tested material: product of the present invention: embodiment 1, matched group: purified water.
2. animal and feeding environment:
New Zealand White rabbit 4, regular grade, single cage raising, body weight 2.0-2.3kg.Animal feeding room temperature 21 DEG C～
24 DEG C, relative humidity 62%～66%.
3. test method:
Before 3.1 tests, family's rabbit back spinal column both sides are cut by 24h by hair, not injured skin surface, unhairing scope in cropping
It is respectively 3cm*3cm, application area 2.5cm*2.5cm.
Tested material 0.5ml is spread upon on the skin of side by 3.2, and opposite side is coated with 0.5ml purified water and smears as comparison, every day
1 time, smear 14d continuously.From the beginning of second day, smear front cropping every time, remove residual tested material with olive oil.See after one hour
Examine result, mark by the skin irritation/corrosion test table 1 of " cosmetics health specification " (2007 editions), check plot and
Trial zone processes equally.
3.3 evaluation of result: calculate rabbit average integral every day every, by the skin of " cosmetics health specification " (2007 editions)
Zest/corrosivity specification sheet judges rabbit skin irritation intensity, and observes other toxic actions beyond zest.
4. result of the test: result shows, in product of the present invention carries out repeatedly the irritation test observation period, rabbit does not all have
Occur erythema and edema；Every day every, animal average integral was 0, has no other toxic reaction features, shows product of the present invention
Repeatedly irritation test result is non-stimulated.
5. experiment conclusion: the many skins of the present invention are detected as non-stimulated, shows that product of the present invention has tight security.
Experiment three: product of the present invention is to eye irritation effect or corrosiveness and degree test thereof.
1. material and sample: material, the regular grade New Zealand White rabbit three of laboratory animal weight (1.7-2.2kg)
Only.Sample, whether two eyes of pretest inspection animal subject damage and injure inflammatory reaction, on inspection, have no corneal defect and
Conjunctival damage and inflammatory reaction.
2. test method: by " cosmetics health specification " (2007 editions) acute ocular zest corrosivity.
Tested material 0.1ml being inserted on the right side of laboratory animal in eye conjunctival sac, by upper and lower catacleisis 1s, left side eye is as right
According to.In instillation the 1 of tested material, 24,48 and 72h handheld slit lamp, animal eyes is checked, observe and note at 24h simultaneously
After record terminates, the eyes fluorescein sodium of all animals is checked.Not recuperator in 7d, for determining the reversibility of this infringement
Or irreversibility need to extend observing time, it is usually no more than 21d, and records 7d, 14d, 21d visual report；If 72h does not goes out
Existing irritant reaction, gets final product termination test.
3. the eye irritation result of the test (experiment condition: do not rinse) of rabbit is shown by inventive samples, animal after contamination
Conjunctiva, cornea, iris are 0 in the irritant reaction value of 1,24,48 and 72h.The product of the present invention acute ocular zest to rabbit
Result of the test is nonirritant.
4. experiment conclusion: acute ocular of the present invention stimulates corrosion testing to be non-stimulated, shows that product of the present invention has height peace
Quan Xing.
Experiment four: water proof, every wet experiment.
1. experiment purpose: test this product water proof, every wet effect.
2. experimental procedure: choose test zone (4cm*5cm) at inboard arm, including tested region and control zone, uses
Test zone is cleaned and dries by fancy soap, measures the initial water score value of tested region and control zone.Take 0.1g sample in tested
Region is also smeared uniformly, dries 5min, by cotton pads matte towards being placed down in tested region and dripping 3mL pure water, wipes after 10min
Anhydrate and sample test moisture, simultaneously by cotton pads matte towards being placed down in control zone and dripping 3mL pure water, wipe after 10min
Anhydrate testing moisture.
3. analysis of experimental data is as shown in table 2 and table 3:
Table 2
Table 3
Significance: "+": significant difference (p≤0.05)；"-": non-limiting difference (p > 0.05)
4. experimental result: after product uses, after immersion processes, moisture raises substantially less than control zone, and product is tested
Zone leveling is less than control zone 19.65, has notable water proof effect.
5. experiment conclusion: this experiment proves that the present invention possesses the effect of isolation moisture, can form one layer of guarantor on skin
Protecting property oil film, isolation baby's urine, to the infiltration of skin and stimulation, reduces owing to friction and urine stimulate the baby's diaper dermatitis caused.
Experiment five: both effectiveness experiment.
1, test object: for meeting slight " diaper dermatitis (diaper rash) " infant of baby napkin dermatitis diagnostic criteria, skin without
Breakage, in diaper covering part, such as perineum, scrotum, femoribus internus, buttocks etc., it is seen that lamellar erythema, with diaper area coverage
Match, clear-cut margin.0-3 one full year of life baby, men and women does not limits, and studies first 1 month and did not used wetting agent in skin lesion district, be not administered orally
Cross antihistaminic and glucocorticoid is crossed in non-external, and the guardian of experimenter must assure that 24 hours before assessment
Period, various basic products must not be used in skin lesion district, hip pad product and glucocorticoid ointment etc. must not be used.
2. experimental procedure: complete case load 28 example, before coating diaper ointment, by the position warm water wash clean that need to apply also
Soft cloth is dried gently, smears stern protection cream in affected part, thickness about 0.5-1.0mm, twice daily, respectively at the 1st day, the 2nd day, the 3rd
My god, within the 4th day, the 5th day, the 6th day, the 7th day, be observed, during observation, diaper dermatitis disappear be healing, record this time is diaper dermatitis
Disappearance natural law, the like record is corresponding accumulative cures case load and corresponding time.
3. experimental result: diaper dermatitis (diaper rash) disappears accumulative number of cases time statistical table as shown in table 4 (N=28):
Table 4
| Time | 1st day | 2nd day | 3rd day | 4th day | 5th day | 6th day | 7th day |
| Accumulative healing case load | 0 | 0 | 1 | 5 | 12 | 16 | 23 |
| Cure rate | 0 | 0 | 3.57% | 17.86% | 42.86 | 57.14 | 82.14% |
4. experiment conclusion:
This product can promote the rehabilitation of slight diaper dermatitis (diaper rash), and slight diaper dermatitis (diaper rash) is had certain effect.
From the foregoing, it will be observed that the dosage form that the present invention uses is Water-In-Oil cream shape, isolated form oils and fats is utilized to form one on skin
Determine the physics water proof air-permeable layer of thickness, urine, dampness and physical property friction can be completely cut off, reduce diaper rash and occur；Meanwhile, utilization is relaxed
Slow type natural plant composition Butyrospermum parkii fruit fat, Fructus oleae europaeae fruit oil, bisabolol and the mixture of ginger-root extract, outside releiving
Boundary stimulates the sense of discomfort causing skin.Utilize tocopherol acetas can help impaired skin by Glycerin with the mixture of pantothenylol
Healing.Thus, product of the present invention has and has dual function, has both been possible to prevent diaper rash, and diaper rash can be helped again to recover.This
Bright compare conventional art for, there is the simple feature of safety, high efficiency, and preparation method simultaneously.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (5)
1. an infant buttocks-care cream, it is characterised in that include following weight parts component:
Wherein, the described mixture that isolated form oils and fats is vaseline and lanoline；Stabilizer is lanolin alcohol；Composition of releiving is
Butyrospermum parkii fruit fat, Fructus oleae europaeae fruit oil, bisabolol and the mixture of ginger-root extract；It is tocopherol second that skin moistening nourishes composition
Acid esters and the mixture of pantothenylol.
Infant buttocks-care cream the most according to claim 1, it is characterised in that include following weight parts component:
Infant buttocks-care cream the most according to claim 1, it is characterised in that described skin moistening nourishes composition and also includes allantois
One or several mixture in element, cetearyl alcohol ethylhexoate and tribehenin essence.
Infant buttocks-care cream the most according to claim 1, it is characterised in that include following weight parts component:
Isolated form oils and fats: 9 parts of vaseline, lanoline 5 parts；
Thickening agent: 1 part of Cera Flava, cetearyl alcohol 1 part；
Stabilizer: lanolin alcohol 5 parts；
Releive composition: Butyrospermum parkii fruit 9 parts of fat, Fructus oleae europaeae fruit oil 2 parts, bisabolol 0.2 part, ginger-root extract 0.001 part；
Skin moistening nourishing composition: tocopherol acetas 0.1 part, pantothenylol 5 parts, cetearyl alcohol ethylhexoate 8 parts；
Water: 55 parts.
5. the method for preparation infant buttocks-care cream described in any one of claim 1-4, it is characterised in that comprise the steps:
1): by isolated form oils and fats, thickening agent, stabilizer and composition mixing post-heating of releiving to 70-75 DEG C, stirring and dissolving is complete
After to obtain oil phase component A standby；
If skin moistening nourishes contains other oil-soluble ingredients in composition in addition to tocopherol acetas, then this oil-soluble ingredients is heated
To 70-75 DEG C, stirring and dissolving is complete, obtains oil phase B component standby；
2): the water soluble ingredient nourished by skin moistening in composition is added to the water mix homogeneously, being warming up to 70-75 DEG C, stirring and dissolving is complete
Entirely, water-phase component is obtained standby；
3): under vacuum homogenizing stirs, by step 2) water-phase component that obtains is dividedly in some parts step 1) in the oil phase component that obtains,
Homogenous disperse is uniform；Stirring is cooled to 45 DEG C-50 DEG C, adds tocopherol acetas, and dispersed with stirring is uniform；Continue stirring to be cooled to
Room temperature, i.e. can get product of the present invention；
When not containing other oil-soluble ingredients in addition to tocopherol acetas during skin moistening nourishes composition, described oil phase component is oil
Phase component A；When containing other oil-soluble ingredients in addition to tocopherol acetas during skin moistening nourishes composition, described oil phase component is
Oil phase component A and the mixture of oil phase B component.
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| CN107456408A (en) * | 2017-08-17 | 2017-12-12 | 成都新柯力化工科技有限公司 | A kind of gentle children's skin protection bath cream and preparation method thereof |
| CN107693466A (en) * | 2017-07-17 | 2018-02-16 | 彭欢 | A kind of paste with effects of beautification and nourishing face |
| CN109172423A (en) * | 2018-11-02 | 2019-01-11 | 广州环亚化妆品科技有限公司 | A kind of essence fluid composition and its preparation method and application |
| CN110522659A (en) * | 2019-08-08 | 2019-12-03 | 艾伯尔生物科技（重庆）有限公司 | A kind of striae of pregnancy repair cream and preparation method thereof |
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