CN110522659A

CN110522659A - A kind of striae of pregnancy repair cream and preparation method thereof

Info

Publication number: CN110522659A
Application number: CN201910731701.5A
Authority: CN
Inventors: 杨陈
Original assignee: Abel Biotechnology (chongqing) Co Ltd
Current assignee: Abel Biotechnology (chongqing) Co Ltd
Priority date: 2019-08-08
Filing date: 2019-08-08
Publication date: 2019-12-03

Abstract

The present invention relates to a kind of striae of pregnancy repair creams and preparation method thereof, the repair cream is the olive oil of 2.0-5.0:0.1-0.5:0.1-1.0 with weight fraction ratio, Butyrospermum parkii fruit rouge and tocopherol acetate are as active constituent, it further include following auxiliary material: GP200 emulsifier, WR emulsifier, palmitinic acid isooctyl, caprylic/capric triglyceride, Cer NS, isononyl isononanoate, dimethyl silicone polymer, cetostearyl alcohol, beeswax, DC345 silicone oil, propyl ester, phosphorus sodium calcium silicate, xanthan gum, glycerol, water, polyethylene glycol-400, Sodium Hyaluronate, 1, 3- butanediol, trimethylglycine, EDETATE SODIUM, allantoin, dipotassium glycyrrhizinate, methyl esters and PE9010 preservative.Repair cream of the invention can percutaneous absorbtion, effectively remove striae of pregnancy and scar, and there is replenishing water and preserving moisture effect.Preparation method simple process provided by the invention, it is environmental-friendly, it is suitble to industrialized production.

Description

A kind of striae of pregnancy repair cream and preparation method thereof

Technical field

The present invention relates to cosmetic fields, and in particular to a kind of striae of pregnancy repair cream and preparation method thereof.

Background technique

The formation of striae of pregnancy mainly causes the elastic fibers of skin and collagenous fibres to damage since pregnancy period abdomen quickly swells Wound or fracture, skin of abdomen because excessively pull it is thinning attenuate, thus occur different some width, pink different in size or The wavy decorative pattern of aubergine.After childbirth, these decorative patterns can fade away, and leave white or argenteous glossiness scar line Line, i.e. striae of pregnancy.And the formation of scar, it is the slight hyperplasia of connective tissue by normal skin tissue after various wounds and causes 's.The identical point of the two has the overexpression accumulation of surface of a wound collagen fibrous proteins, therefore, decompose the collagen egg that the surface of a wound is excessively secreted It is white to effectively remove and alleviate striae of pregnancy and scar.

In life, the crowd perplexed by striae of pregnancy and scar is more and more, and targetedly treatment method is also increasingly By everybody concern.There are several common therapeutic schemes for being directed to striae of pregnancy and scar at present, sutured as excision scar is noninvasive, Scar, drug injection, scar attrition, laser therapy etc. in scar are repaired after expanding normal skin by soft tissue expander, can change Kind appearance, alleviates scar hyperplasia, but cannot repair scar completely, and the time is long, costly, has certain side effect, effect is not to the utmost Such as people's will.

Summary of the invention

The problem to be solved by the present invention is that in view of the above shortcomings of the prior art, provide a kind of striae of pregnancy repair cream and Preparation method, repair cream formula components safety provided by the invention, convenient for operation, scar of dispelling significant effect makees human body without pair With.

According to an aspect of the present invention, a kind of striae of pregnancy repair cream, including following raw material are provided: active constituent and auxiliary Material, the active constituent be olive oil, Butyrospermum parkii fruit rouge and tocopherol acetate, the olive oil, Butyrospermum parkii fruit rouge and The weight fraction ratio of tocopherol acetate is 2.0-5.0:0.1-0.5:0.1-1.0.

Further, the auxiliary material includes GP200 emulsifier, WR emulsifier, palmitinic acid isooctyl, caprylic/capric glycerol three Ester, Cer NS, isononyl isononanoate, dimethyl silicone polymer, cetostearyl alcohol, beeswax, DC345 silicone oil, propyl ester, phosphorus silicon Sour sodium calcium, xanthan gum, glycerol, polyethylene glycol-400, Sodium Hyaluronate, 1,3-BDO, trimethylglycine, EDETATE SODIUM, Allantoin, dipotassium glycyrrhizinate, methyl esters and PE9010 preservative.

Further, the striae of pregnancy repair cream includes following material composition according to parts by weight:

According to another aspect of the present invention, a kind of preparation method of striae of pregnancy repair cream is provided, comprising the following steps:

S1: the raw material of mixing A1 group phase is warming up to 65-75 DEG C, and stirring is added the raw material of A2 group phase, stirs to being completely dissolved It mixes uniformly, obtains material 1；

S2: the raw material of B1 group phase is uniformly mixed, is heated to 60-70 DEG C, obtains material 2；

S3: material 1 is added in material 2, emulsion pot is added after mixing, opens stirring, the raw material of B2 group phase is added Emulsion pot stirs evenly, and is heated to 70 DEG C, and homogeneous 10-20min obtains material 3；

S4: 3 to 20 DEG C of material of cooling is added C group phase raw material and is uniformly mixed, obtains material 4；

S5: discharging after detecting qualification to material 4, filling to get the striae of pregnancy repair cream.

Further, after the raw material of A1 group phase being mixed in step S1, be warming up to 70 DEG C.

Further, after the raw material of B1 group phase being mixed in step S2, be warming up to 65 DEG C.

Further, homogenizing time described in step S3 is 10min.

GP200 emulsifier, i.e. Polawax GP200 (manufacturer's brand be CRODA), are a kind of O/W emulsifiers, mainly by PEG-20 stearate, cetostearyl alcohol composition, emulsifying capacity is strong, easy to use.

WR emulsifier, i.e. Sensanov WR (manufacturer's brand is France SEPPIC), are a kind of anionic emulsifier, It is mainly made of C20-22 phosphate and C20-22 fatty alcohol, there is good water-resistance.

The viscosity of dimethyl silicone polymer increases with the increase of molecular weight, and the present invention uses DC200/350 poly dimethyl Siloxanes (manufacturer's brand is DOW CORNING DOW CORNING).

DC345 silicone oil, i.e. PMX-0345 (manufacturer's brand is DOW CORNING DOW CORNING), mainly by the poly- diformazan of ring penta Radical siloxane, cyclohexasiloxane composition, can be used as the base oil ingredient of cosmetics, and spreadability is good, easy to apply, lubricates and has suitable When volatility.

PE9010 preservative, i.e. PE9010 (manufacturer's brand is Germany Shu Mei EUXYL), are Phenoxyethanol and ethylhexyl The liquid preservative used for cosmetic of glycerol compounding, all has good inhibiting effect to bacterium, saccharomycete and enzyme bacterium.

Xanthan gum, also known as xanthan gum are a kind of monospore polysaccharides generated by pseudo xanthomonas fermentation, by cabbage black rot Xanthomonas campestris, through aerobic fermentation biotechnology, cuts off 1,6- glycosidic bond, beats using carbohydrate as primary raw material It pays wages after chain, is being bonded to a kind of acidic extracellular heteroglycan of acidity that straight chain forms by Isosorbide-5-Nitrae-.Since it is with macromolecular structure and glue The characteristic of body can be used as emulsifier, stabilizer, gelling thickener etc., be widely used in food, cosmetic field.

Tocopherol acetate (Tocopheryl Acetate) is also referred to as Vitwas E, is one kind by vitamin E The compound of (also known as tocopherol) and acetic acid progress esterification generation.For in cosmetics, can delay skin aging, increase skin Skin elastic force plays moisten effect to skin and keeps moisture of skin.

Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge, belongs to fatty acid compound, with the rouge in skin Fat acid structure is similar, when its fatty acid molecule is inserted into cuticula class lipid bilayer hydrophobic structure, since its unsaturation is hydrophobic The cis-structure of side chain, reverses bilayer, effectively facilitates percutaneous absorbtion.

The present invention comprehensively considered moisten, moisturizing, removal striae of pregnancy (scar), anti-aging, use feeling etc. it is various because Element, in order to reach optimal removal striae of pregnancy effect, the development process of formula of the invention have passed through a large amount of trial and adjustment, Beneficial effects of the present invention are as follows:

The raw material components of repair cream of the invention are the common ingredient of cosmetics, and raw material is easy to get, is low in cost；The present invention By selecting each concrete component and its proportion, under this proportion, repair cream can effective percutaneous absorbtion, rapid osmotic to skin corium, The effects of to play moist, moisturizing, removal striae of pregnancy (scar).

In the present invention, the olive oil for 2.0-5.0:0.1-0.5:0.1-1.0, Butyrospermum parkii fruit rouge and tocopherol will be matched Acetic acid esters is as removal striae of pregnancy (scar), the main component of anti-aging.Under this proportion, repair cream, which can promote, decomposes surface of a wound mistake More collagen fibrous proteins, to be effectively relieved and remove striae of pregnancy and scar.Between the missing of any ingredient or each ingredient Proportion changes, and can all make the significant effect decline of the removal striae of pregnancy of repair cream.

The characteristics of emulsifier and the categories of excipients for being used to prepare cosmetics are various, and the present invention is according to main active, The reasonable selection matrix such as corresponding emulsifier and excipient, the repair cream being prepared can not only effectively remove striae of pregnancy, also It can be well realized the effect of moisturizing, moisturizing, while also there is advanced use feeling, in use without greasy feeling, It easily pushes open, skin is affine to be felt.

Preparation process provided by the invention uses unique emulsification method, can sufficiently merge each component, Jin Erfa Wave maximum removal striae of pregnancy effect；And preparation process of the invention is generated without exhaust gas, waste liquid, environmentally friendly, simple process, It is suitble to industrialized production.

Detailed description of the invention

By reading the following detailed description of the preferred embodiment, various other advantages and benefits are common for this field Technical staff will become clear.The drawings are only for the purpose of illustrating a preferred embodiment, and is not considered as to the present invention Limitation.And throughout the drawings, the same reference numbers will be used to refer to the same parts.In the accompanying drawings:

Fig. 1 shows the flow chart of the preparation method of the striae of pregnancy repair cream of embodiment according to the present invention.

Specific embodiment

The illustrative embodiments of the disclosure are more fully described below with reference to accompanying drawings.Although showing this public affairs in attached drawing The illustrative embodiments opened, it being understood, however, that may be realized in various forms the disclosure without the reality that should be illustrated here The mode of applying is limited.It is to be able to thoroughly understand the disclosure on the contrary, providing these embodiments, and can be by this public affairs The range opened is fully disclosed to those skilled in the art.

Raw manufacturer/the supplier of the raw material of following example 1-6 and comparative example 1-5 is documented identical with summary of the invention, Do not record manufacturer person be can be by the conventional reagent product of commercially available acquisition；Embodiment 1-6 and comparative example 1-5 is using preparation Method is identical, the preparation method being all made of in embodiment 7.

Embodiment 1-6

Comparative example 1

Except Butyrospermum parkii fruit rouge is not included in raw material, remaining is same as Example 2.

Comparative example 2

Except olive oil is not included in raw material, remaining is same as Example 2.

Comparative example 3

Except tocopherol acetate is not included in raw material, remaining is same as Example 2.

Comparative example 4

Except the parts by weight of olive oil, Butyrospermum parkii fruit rouge and tocopherol acetate in raw material are respectively as follows: 2.0,1.5, 2.0, remaining is same as Example 2.

Comparative example 5

Except GP200 emulsifier in raw material, the parts by weight of beeswax, xanthan gum, trimethylglycine are respectively as follows: 4.0, 0.05,0.8,3.5, remaining is same as Example 2.

Embodiment 7

The repair cream of embodiment 1-6 and comparative example 1-5 the preparation method is as follows:

S1: the raw material of mixing A1 group phase is warming up to 70 DEG C, and the raw material of A2 group phase is added to being completely dissolved in stirring, and stirring is equal It is even, obtain material 1 (mixing A phase)；

S2: by B1 group phase raw material xanthan gum and glycerol be uniformly mixed, be heated to 65 DEG C, obtain material 2；

S3: material 1 is added in material 2, emulsion pot is added after mixing, opens stirring, the raw material of B2 group phase is added Emulsion pot stirs evenly, and is heated to 70 DEG C, and homogeneous 10min obtains material 3；

S5: discharging after detecting qualification to material 4, filling.

Experimental example efficacy assessments

The repair cream that embodiment 1-6 and comparative example 1-5 are obtained selects 15 subjects to carry out effect assessment, subject respectively It is the patient with striae of pregnancy or operative scar, repair cream is smeared in affected part, is smeared after cleaning illing skin daily morning and evening, is smeared Amount is 2mg/cm², it is used continuously one month, evaluates effect.

Efficacy assessments standard is as follows:

It is effective: striae of pregnancy and scar is thin out and 50% or more range shorter；

It is effective: striae of pregnancy and scar is thin out and 20% or more range shorter；

Invalid: striae of pregnancy and scar are not reduced without thin out or range.

Efficient=effective number of cases/total number of cases × 100%.

Efficacy assessments result is as shown in the table

Evaluation result shows that the repair cream of embodiment 1-6 reaches 80.0- to the reparation effective percentage of striae of pregnancy or scar 93.3%, remove the significant effect of striae of pregnancy and scar；By the result of comparative example 1-4 it is found that as main active, olive It matches and changes between oil, Butyrospermum parkii fruit rouge and the missing or each ingredient of any ingredient of tocopherol acetate, can all make repair cream The effect of be remarkably decreased；It can be used for preparing that the raw materials such as emulsifier, moisturizer, the stabilizer of cosmetics are numerous, and the present invention is according to master The characteristics of wanting active constituent has selected the concrete component and proportion of each raw material, absorb repair cream can effectively rapid transdermal, plays It moistens, moisturizing, remove the effect of striae of pregnancy and scar, by the result of comparative example 5 it is found that the ratio of changing section ingredient, can make The obvious effective rate of repair cream is remarkably decreased.

The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, In the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of by anyone skilled in the art, It should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of the claim Subject to enclosing.

Claims

1. a kind of striae of pregnancy repair cream, which is characterized in that including following raw material: active constituent and auxiliary material, the active constituent are Olive oil, Butyrospermum parkii fruit rouge and tocopherol acetate, the weight of the olive oil, Butyrospermum parkii fruit rouge and tocopherol acetate Portion rate is 2.0-5.0:0.1-0.5:0.1-1.0.

2. striae of pregnancy repair cream as described in claim 1, which is characterized in that the auxiliary material includes GP200 emulsifier, WR emulsification Agent, palmitinic acid isooctyl, caprylic/capric triglyceride, Cer NS, isononyl isononanoate, dimethyl silicone polymer, spermaceti Stearyl alcohol, beeswax, DC345 silicone oil, propyl ester, phosphorus sodium calcium silicate, xanthan gum, glycerol, polyethylene glycol-400, Sodium Hyaluronate, 1, 3- butanediol, trimethylglycine, EDETATE SODIUM, allantoin, dipotassium glycyrrhizinate, methyl esters and PE9010 preservative.

3. striae of pregnancy repair cream as claimed in claim 2, which is characterized in that the raw material including following parts by weight:

1.0-3.0 parts of GP200 emulsifier, 0.1-1.0 parts of WR emulsifier, 2.0-5.0 parts of palmitinic acid isooctyl, caprylic/capric is sweet Oily 2.0-5.0 parts of three ester, 2.0-5.0 parts of isononyl isononanoate, 2.0-5.0 parts of olive oil, gathers by 0.05-0.2 parts of Cer NS 1.0-3.0 parts of dimethyl siloxane, 1.0-3.0 parts of cetostearyl alcohol, 0.1-1.0 parts of beeswax, Butyrospermum parkii fruit rouge 0.1-0.5 Part, 0.1-0.5 parts of DC345 silicone oil, 0.05-0.2 parts of propyl ester, 0.1-1.0 parts of tocopherol acetate, phosphorus sodium calcium silicate 3.0-8.0 Part, 0.1-0.5 parts of xanthan gum, 2.0-4.0 parts of glycerol, 55-70 parts of water, 1.0-4.0 parts of polyethylene glycol-400, Sodium Hyaluronate 0.05-0.2 parts, 2.0-4.0 parts of 1,3-BDO, 0.5-2.0 parts of trimethylglycine, 0.05-0.2 parts of EDETATE SODIUM, allantois It is 0.1-0.5 parts plain, 0.1-0.5 parts of dipotassium glycyrrhizinate, 0.1-0.5 parts of methyl esters, 0.1-1.5 parts of PE9010 preservative.

4. striae of pregnancy repair cream as claimed in claim 2, which is characterized in that the raw material including following parts by weight:

1.0 parts of GP200 emulsifier, 0.7 part of WR emulsifier, 2.5 parts of palmitinic acid isooctyl, 2.8 parts of caprylic/capric triglyceride, 0.1 part of Cer NS, 3.0 parts of isononyl isononanoate, 4.0 parts of olive oil, 2.0 parts of dimethyl silicone polymer, cetostearyl alcohol 1.5 parts, 0.5 part of beeswax, 0.4 part of Butyrospermum parkii fruit rouge, 4.0 parts of DC345 silicone oil, 0.1 part of propyl ester, 0.5 part of tocopherol acetate, 4.0 parts of phosphorus sodium calcium silicate, 0.4 part of xanthan gum, 3.0 parts of glycerol, 65 parts of water, 3.0 parts of polyethylene glycol-400, Sodium Hyaluronate 0.2 Part, 3.0 parts of 1,3-BDO, 2.0 parts of trimethylglycine, 0.1 part of EDETATE SODIUM, 0.3 part of allantoin, dipotassium glycyrrhizinate 0.2 Part, 0.3 part of methyl esters, 1.0 parts of PE9010 preservative.

5. such as the preparation method of the described in any item striae of pregnancy repair creams of claim 3-4, which is characterized in that including following step It is rapid:

Weighing each raw material, A1 group mutually includes GP200 emulsifier, WR emulsifier, palmitinic acid isooctyl, caprylic/capric triglyceride, Cer NS, isononyl isononanoate, olive oil, dimethyl silicone polymer, cetostearyl alcohol, beeswax, Butyrospermum parkii fruit rouge, DC345 silicone oil, propyl ester, tocopherol acetate；

A2 group mutually includes phosphorus sodium calcium silicate；

B1 group mutually includes xanthan gum and glycerol；

B2 group mutually includes water, polyethylene glycol-400, Sodium Hyaluronate, 1,3-BDO, trimethylglycine, EDETATE SODIUM, urine Bursin, dipotassium glycyrrhizinate and methyl esters；

C group mutually includes PE9010 preservative；

S1: the raw material of mixing A1 group phase is warming up to 65-75 DEG C, and the raw material of A2 group phase is added to being completely dissolved in stirring, and stirring is equal It is even, obtain material 1；

S3: being added material 1 for material 2, emulsion pot be added after mixing, open stirring, and emulsification is added in the raw material of B2 group phase Pot, stirs evenly, is heated to 70 DEG C, homogeneous 10-20min obtains material 3；

6. the preparation method of striae of pregnancy repair cream as claimed in claim 5, which is characterized in that by the original of A1 group phase in step S1 After material mixing, it is warming up to 70 DEG C.

7. the preparation method of striae of pregnancy repair cream as claimed in claim 5, which is characterized in that by the original of B1 group phase in step S2 After material mixing, it is warming up to 65 DEG C.

8. the preparation method of striae of pregnancy repair cream as claimed in claim 5, which is characterized in that homogenizing time described in step S3 For 10min.