CN106260594B - A kind of pre-mixing feed additive for improving sow reproductive performance - Google Patents
A kind of pre-mixing feed additive for improving sow reproductive performance Download PDFInfo
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Abstract
The invention discloses a kind of pre-mixing feed additives for improving sow reproductive performance, the pre-mixing feed additive is mainly by composite antibacterial peptide moiety, it forms including Catfish antimicrobial peptide mutant, sea hare antibacterial peptide mutant, maduca sexta antibacterial peptide mutant, enterococcus faecium and auxiliary material, is used suitable for sow is whole.Method of the present invention can significantly improve swinery intestinal microecology, it is obviously improved sow immunity, and then improve sow reproductive performance, it is exactly specifically to increase the total young number of tire, tire young number living, the strong young number of tire, and compared with the existing methods, many nutrition can also be provided, improve the breast matter amount and quantity of sow, enhance the constitution of piglet, reduce breeding cycle.
Description
Technical field
The invention belongs to the technical fields of animal feed, and in particular to a kind of premixed feed for improving sow reproductive performance
Additive.
Background technology
With development and management development that intensive, large scale of pig farm produces, manufacturer is in order to realize sow group
The high efficiency of production, it is higher and higher to the quality of swinery, kind, the requirement of health status farrowing rate.By improving management means, make
Swinery carries out full production, the ratio for causing swinery extremely superseded therefrom is opposite under stringent production schedule control
Increase.At present in pig production, the problem of puzzlement pig raising people is：Litter size is few, and the reproductive capacity on pig farm is caused to decline, sow group
Supplement is difficult.If we increase sow livestock on hand, farrowing nest number is improved, the feeding cost of sow certainly will be increased, and also resulted in
The field of sow house is nervous；The opposite livestock on hand for being not added with sow, childbirth, child care are bred as the field relative free of house, cause to waste
And increase cost.Sow occupies critically important status in pig production, and the health of sow is to entire pig production efficiency to pass
It is important.Sow will undergo gestation, lactation and nonpregnant three cycles and breeding, farrowing and wean three in the normal breeding cycle
Link, any link go wrong, and can reduce sow reproductive performance, reduce production efficiency.
In these links, colony balance plays an important role in the immune level and alimentary canal of sow, sow alimentary canal
The unbalance generation that can cause animal intestinal tract disease of microorganism, such as constipation, diarrhea, and the decline of immunity causes a variety of diseases
Occur and sow is in sub-health state.
Many studies have shown that probiotics and antibacterial peptide are added in sow feed, it is young to Milking ability, milk quality, wean
The reproductive performances such as pig weight have certain facilitation.Gorgeous equality is opened respectively to through production and the antenatal 7d of first farrowing sow every feeding daily
Probiotics is fed, it turns out that, Suprapubic arch sling group and first farrowing sow group, piglet speed of growth, piglet survival ratio significantly improve.
The researchs such as Li Bo show that addition cecropin antimicrobial peptides can significantly improve sow in the antenatal gestation material of sow and postpartum breastfeeding material
Reproductive performance and the growth performance of piglet improve the general level of the health of piglet.
People largely add chemicals and antibiotic in feed, are achieved to improving fertility of sow and prevention disease
Certain effect, but its effect is not satisfactory, and easy medicament residue problem, health is adversely affected.
The content of the invention
It is an object of the invention to provide a kind of pre-mixing feed additives for improving sow reproductive performance.
The technical solution used in the present invention is：
A kind of pre-mixing feed additive, feed addictive percentage meter by weight contain following components：0.5%~
10% Catfish antimicrobial peptide mutant, 0.5%~10% sea hare antibacterial peptide mutant Da-B2M, 0.5%~10% maduca sexta resist
Bacterium peptide mutant Ms-mcM and 0.5%~10% enterococcus faecium agent.
Further, feed addictive percentage meter by weight contains following components：0.5%~10% Catfish antimicrobial peptide
Mutant, 0.5%~10% sea hare antibacterial peptide mutant Da-B2M, 0.5%~10% maduca sexta antibacterial peptide mutant Ms-
McM, 0.5%~10% enterococcus faecium agent, surplus is auxiliary material.
Further, feed addictive percentage meter by weight contains following components：2.0%~6.0% catfish antibacterial
Peptide mutant, 1.0%~2.0% sea hare antibacterial peptide mutant Da-B2M, 1.0%~2.0% maduca sexta antibacterial peptide mutant
Ms-mcM, 0.5%~10% enterococcus faecium agent, surplus is auxiliary material.
Further, the Catfish antimicrobial peptide mutant, sea hare antibacterial peptide mutant Da-B2M and maduca sexta antibacterial peptide
The mass ratio of mutant is 4:1:1.
Further, feed addictive percentage meter by weight contains following components：4.0% Catfish antimicrobial peptide is mutated
Body, 1.0% sea hare antibacterial peptide mutant Da-B2M, 1.0% maduca sexta antibacterial peptide mutant Ms-mcM, 0.5% dung intestines ball and
93.5% auxiliary material.
Further, the amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：
1)。
Further, the amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is
SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ(SEQID NO：2).
Further, the amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
Further, the concentration of enterococcus faecium is 2 × 10 in the enterococcus faecium agent9~3 × 109CFU/g。
Further, the auxiliary material contains antioxidant, multi-vitamins, mineral element additive, cassiri, ferment
At least one of female culture, zeolite powder.
The beneficial effects of the invention are as follows：
1) pre-mixing feed additive of the present invention contains specific composite antibacterial peptide moiety, i.e., Catfish antimicrobial peptide mutant,
Sea hare (Dolabella auricularia) antibacterial peptide (Dolabellanin B2) mutant Da-B2M, maduca sexta
(Manduca sexta) antibacterial peptide MS moricin mutant Ms-mcM；Also contain specific enterococcus faecium simultaneously
(Enterococcus faecium) GLM105, deposit number are CGMCC No.11155, are used suitable for sow is whole；This hair
The mutant of the bright specific antibacterial peptide of selection and the combination application of specific bacterial strain, play better effect, are more advantageous to improving female
Swine reproduction performance is exactly specifically to increase the total young number of tire, tire young number living, the strong young number of tire, and with existing method
It compares, many nutrition can also be provided, improve the breast matter amount and quantity of sow, enhance the constitution of piglet, while can shorten
Feeding time and scale of feeding reduce production cost.
2) the effect of present invention can improve Swinery immunity power using specific antibacterial peptide mutant and specific bacterial strain promotes sow
The function of reproductive capacity, and compared to traditional medicine physical property additive, there are noresidue, the more low many merits of production cost.
3) present invention is according to the features such as antibacterial characteristics, the immunocompetence of different antibacterial peptides, specific compounding different type
Antibacterial peptide, obtain recombinant antimicrobial peptide；It is aided with pig endogenous bacterial strain (enterococcus faecium) simultaneously, ultimately forms recombinant antimicrobial peptide, benefit
The compound premixing feed additives of raw bacterium compounding.The experimental results showed that compound premixing feed additives can significantly improve sow reproductive ability
Energy (the total young number of tire, tire young number living, tire are good for young number etc.), while many nutrition can also be provided, improve sow
Breast matter amount and quantity enhance the constitution of piglet, reduce the feeding piglet cycle.Method of the present invention is at low cost, and the cycle is short, makes
With conveniently, practical application is made great sense.
Specific embodiment
A kind of pre-mixing feed additive, feed addictive percentage meter by weight contain following components：0.5%~
10% Catfish antimicrobial peptide mutant, 0.5%~10% sea hare antibacterial peptide mutant Da-B2M, 0.5%~10% maduca sexta resist
Bacterium peptide mutant Ms-mcM and 0.5%~10% enterococcus faecium agent.
Preferably, feed addictive percentage meter by weight contains following components：0.5%~10% Catfish antimicrobial peptide is dashed forward
Variant, 0.5%~10% sea hare antibacterial peptide mutant Da-B2M, 0.5%~10% maduca sexta antibacterial peptide mutant Ms-mcM,
0.5%~10% enterococcus faecium agent, surplus are auxiliary material.
Preferably, feed addictive percentage meter by weight contains following components：2.0%~6.0% Catfish antimicrobial peptide
Mutant, 1.0%~2.0% sea hare antibacterial peptide mutant Da-B2M, 1.0%~2.0% maduca sexta antibacterial peptide mutant Ms-
McM, 0.5%~10% enterococcus faecium agent, surplus is auxiliary material.
Preferably, the Catfish antimicrobial peptide mutant, sea hare antibacterial peptide mutant Da-B2M and maduca sexta antibacterial peptide are dashed forward
The mass ratio of variant is 4:1:1.
Preferably, feed addictive percentage meter by weight contains following components：4.0% Catfish antimicrobial peptide mutant,
1.0% sea hare antibacterial peptide mutant Da-B2M, 1.0% maduca sexta antibacterial peptide mutant Ms-mcM, 0.5% dung intestines ball and
93.5% auxiliary material.
Preferably, the amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：1).
Preferably, the amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is
SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ(SEQID NO：2).
Preferably, the amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
Preferably, the concentration of enterococcus faecium is 2 × 10 in the enterococcus faecium agent9~3 × 109CFU/g。
Preferably, the Classification And Nomenclature of the enterococcus faecium be (Enterococcus faecium) GLM105, deposit number
For CGMCC No.11155.
Preferably, the auxiliary material contains antioxidant, multi-vitamins, mineral element additive, cassiri, yeast
At least one of culture, zeolite powder.
It is furthermore preferred that the auxiliary material is composed of the following components：53%~55% cassiri, the training of 32%~33% yeast
Support object, 9%~11% fermented bean dregs, 0.2%~0.4% multi-vitamins, 0.15%~0.25% mineral element additive,
1.0%~2.0% zeolite powder, 1.3%~1.6% calcium monohydrogen phosphate, the percentage are mass percent.
The application method of any of the above-described pre-mixing feed additive, in arm's length basis daily ration add in 0.1%~
0.5% pre-mixing feed additive.
With reference to specific embodiment, the present invention is further illustrated, but is not limited thereto.
A kind of pre-mixing feed additive of Examples 1 to 4
The formula of pre-mixing feed additive prepared by Examples 1 to 4 and the formula of corresponding comparative example 1~3 are as follows
(percentage represents mass percent in table) shown in table 1.
The formula of pre-mixing feed additive prepared by 1 Examples 1 to 4 of table and the formula of corresponding comparative example 1~3
In upper table, the amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：1).
The amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is
SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ(SEQID NO：2).
The amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
The concentration of enterococcus faecium is 2.5 × 10 in the enterococcus faecium agent9CFU/g；The Classification And Nomenclature of the enterococcus faecium
For (Enterococcus faecium) GLM105, deposit number is CGMCC No.11155 (referring to patent document
CN105132321A)。
The formula of the auxiliary material is：54% cassiri, 32.5% yeast culture, 10% fermented bean dregs, 0.3% are answered
Vitamin, 0.2% mineral element additive, 1.5% zeolite powder, 1.5% calcium monohydrogen phosphate are closed, the percentage is quality percentage
Number.
The preparation method of pre-mixing feed additive (hereinafter referred to as premix) is to stir all raw materials in above-mentioned table
After being sufficiently stirred in machine.
5 farm's application experiment of embodiment
Experimental method：This experimental example is carried out in pig farm, is randomly selected 400 healthy adult sows, is randomly divided into 8
Group, wherein the 1st group to the 7th group is experimental group, is separately added into the pre-mixing feed additive of different formulations in table 1 by every group 50
It is raised, the 8th group is control group.Experimental group sow adds 0.3% premixed feed to before weaning after breeding in feed
Additive, control group to before weaning, are normally fed in feed, monthly add week age after the breeding, and record test group and
Control group sow health status, farrowing head number, piglet Birth weight, weaning weight and health status.Test detailed design such as table 2.
2 daily ration structure of table
Experimental period：Start to 28 age in days of piglet to terminate after insemination of sows, amount to 142 days.
Experimental result and conclusion：
(1) influence of the pre-mixing feed additive to sow characterization health status
As shown in table 3, during experiment, the equal feed intake of head, the incidence difference of 7 test groups and control group is not notable,
Various symptoms also no significant difference.The results show that pre-mixing feed additive (premix) of the present invention is improving the characterization of sow
It is not notable with the difference of the premix of comparative example and control group in health status.
3 sow of table characterizes health status
Note：Different lowercase letter indication differences significantly (P ＜ 0.05) capitalization represents difference extremely significantly (P ＜ 0.01).
(2) influence of the pre-mixing feed additive to number born of sow, piglet weak tire, stillborn foetus, mummy
As shown in table 4, using weak 19 fewer than control group of number of son in 1 group of 1 pre-mixing feed additive of embodiment；Stillborn foetus
Number fewer than control group 8,12 fewer than control group of mummy number；Total sodium selenite number is higher than control group 104；
Use weak 16 fewer than control group of number of son in 2 groups of 2 pre-mixing feed additive of embodiment；Stillborn foetus number compares control group
Few 7,11 fewer than control group of mummy number；Total sodium selenite number is higher than control group 95；
Use weak 17 fewer than control group of number of son in 3 groups of 3 pre-mixing feed additive of embodiment；Stillborn foetus number compares control group
Few 6,9 fewer than control group of mummy number；The total sodium selenite number of experimental group is higher than control group 93；
Use weak 15 fewer than control group of number of son in 4 groups of 4 pre-mixing feed additive of embodiment；Stillborn foetus number compares control group
Few 5,9 fewer than control group of mummy number；The total sodium selenite number of experimental group is higher than control group 93；
Use weak 15 fewer than control group of number of son in 5 groups of 1 premix of comparative example；Stillborn foetus number is 3 fewer than control group, wood is
She counts 7 fewer than control group；The total sodium selenite number of experimental group is higher than control group 79；
Use weak 8 fewer than control group of number of son in 6 groups of 2 premix of comparative example；Stillborn foetus number is 4 fewer than control group, wood is
She counts 8 fewer than control group；The total sodium selenite number of experimental group is higher than control group 69；
Use weak 12 fewer than control group of number of son in 7 groups of 3 premix of comparative example；Stillborn foetus number is 2 fewer than control group, wood is
She counts 8 fewer than control group；The total sodium selenite number of experimental group is higher than control group 75.
Summary as a result, pre-mixing feed additive of the present invention to number born of sow, the weak tire of piglet, stillborn foetus, mummy
The influence for waiting sow reproductive performances is more notable, the reproductive performance of the mixed fodder additive on sow of the present invention under different formulations
It is obviously improved, and its effect is also apparently higher than the formula in comparative example, especially using 1 pre-mixing feed additive of embodiment
When, best results are promoted to sow reproductive performance,.
4 number born of sow of table, the weak tire of piglet, stillborn foetus, mummy situation
| Item compared | 1 group | 2 groups | 3 groups | 4 groups | 5 groups | 6 groups | 7 groups | Control group |
| Total young number of health | 630 | 621 | 619 | 619 | 605 | 595 | 601 | 526 |
| Total weak young number | 14 | 17 | 16 | 18 | 18 | 25 | 21 | 33 |
| Total stillborn foetus number | 10 | 11 | 12 | 13 | 15 | 14 | 16 | 18 |
| Total mummy number | 6 | 7 | 9 | 9 | 11 | 10 | 10 | 18 |
(3) influence of the pre-mixing feed additive to sows farrowing head number, suckling pig Birth weight, weaning weight
As shown in table 5, it is higher than 1.3 (P of control group using equal litter size in 1 group of 1 pre-mixing feed additive of embodiment
<0.01), piglet Birth weight is higher than control group 0.23kg (P<0.01), 25 age in days weaned piglets are higher than control group 0.90kg (P again<
0.05)；
It is higher than 1.22 (P of control group using equal litter size in 2 groups of 2 pre-mixing feed additive of embodiment<0.01) it is, young
Pig Birth weight is higher than control group 0.14kg (P<0.05), 25 age in days weaned piglets are higher than control group 0.69kg (P again<0.05)；
It is higher than 1.22 (P of control group using equal litter size in 3 groups of 3 pre-mixing feed additive of embodiment<0.01) it is, young
Pig Birth weight is higher than control group 0.15kg (P<0.05), 25 age in days weaned piglets are higher than control group 0.78kg (P again<0.05)；
It is higher than 1.28 (P of control group using equal litter size in 4 groups of 4 pre-mixing feed additive of embodiment<0.01) it is, young
Pig Birth weight is higher than control group 0.19kg (P<0.05), 25 age in days weaned piglets are higher than control group 0.80kg (P again<0.05)；
Using equal litter size in 5 groups of 1 premix of comparative example higher than control group 1.08, piglet Birth weight is higher than control group
0.09kg, 25 age in days weaned piglets are higher than control group 0.55kg again；
Using equal litter size in 6 groups of 2 premix of comparative example higher than control group 0.98, piglet Birth weight is higher than control group
0.12kg, 25 age in days weaned piglets are higher than control group 0.78kg again；
Using equal litter size in 7 groups of 3 premix of comparative example higher than control group 1.06, piglet Birth weight is higher than control group
0.17kg, 25 age in days weaned piglets are higher than control group 0.76kg again.
5 sows farrowing head number of table, suckling pig Birth weight, weaning weight situation
Note：A represents significant difference (P ＜ 0.05), and A represents difference extremely significantly (P ＜ 0.01).
Summary as a result, pre-mixing feed additive of the present invention to farrowing head number, suckling pig Birth weight, weaning weight etc.
The influence of sow reproductive performance is more notable, and the reproductive performance of the mixed fodder additive on sow of the present invention under different formulations is equal
It is obviously improved, and its effect is also apparently higher than the formula in comparative example, especially using 1 pre-mixing feed additive of embodiment
When, best results are promoted to sow reproductive performance, head number of farrowing weighs 1.51 up to 13.20 ± 0.4, suckling pig birth ±
0.13kg, wean the 7.37 ± 0.24kg that weighs.
A kind of 6 pre-mixing feed additive of embodiment
The present embodiment pre-mixing feed additive percentage meter by weight contains following components：10% Catfish antimicrobial peptide is mutated
Body, 0.5% sea hare antibacterial peptide mutant Da-B2M, 10% maduca sexta antibacterial peptide mutant Ms-mcM and 10% enterococcus faecium
Agent, surplus are auxiliary material；
The amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：1).
The amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is
SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ(SEQID NO：2).
The amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
The concentration of enterococcus faecium is 2.5 × 10 in the enterococcus faecium agent9CFU/g。
The formula of the auxiliary material is：54% cassiri, 32.5% yeast culture, 10% fermented bean dregs, 0.3% are answered
Vitamin, 0.2% mineral element additive, 1.5% zeolite powder, 1.5% calcium monohydrogen phosphate are closed, the percentage is quality percentage
Number.
A kind of 7 pre-mixing feed additive of embodiment
The present embodiment pre-mixing feed additive percentage meter by weight contains following components：0.5% Catfish antimicrobial peptide is mutated
Body, 10% sea hare antibacterial peptide mutant Da-B2M, 0.5% maduca sexta antibacterial peptide mutant Ms-mcM and 5% enterococcus faecium agent,
Surplus is auxiliary material；
The amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：1).
The amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is
SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ(SEQID NO：2).
The amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
The concentration of enterococcus faecium is 2.5 × 10 in the enterococcus faecium agent9CFU/g。
The formula of the auxiliary material is：54% cassiri, 32.5% yeast culture, 10% fermented bean dregs, 0.3% are answered
Vitamin, 0.2% mineral element additive, 1.5% zeolite powder, 1.5% calcium monohydrogen phosphate are closed, the percentage is quality percentage
Number.
A kind of 8 pre-mixing feed additive of embodiment
The present embodiment pre-mixing feed additive percentage meter by weight contains following components：6.0% Catfish antimicrobial peptide is mutated
Body, 2.0% sea hare antibacterial peptide mutant Da-B2M, 1.0% maduca sexta antibacterial peptide mutant Ms-mcM, 4% enterococcus faecium agent,
Surplus is auxiliary material.
The amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：1).
The amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is
SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ(SEQID NO：2).
The amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
The concentration of the enterococcus faecium is 3 × 109CFU/g。
The formula of the auxiliary material is：54% cassiri, 32.5% yeast culture, 10% fermented bean dregs, 0.3% are answered
Vitamin, 0.2% mineral element additive, 1.5% zeolite powder, 1.5% calcium monohydrogen phosphate are closed, the percentage is quality percentage
Number.
A kind of 9 pre-mixing feed additive of embodiment
The present embodiment pre-mixing feed additive percentage meter by weight contains following components：2.0% Catfish antimicrobial peptide is mutated
Body, 1.0% sea hare antibacterial peptide mutant Da-B2M, 2.0% maduca sexta antibacterial peptide mutant Ms-mcM, 10% enterococcus faecium
Agent, surplus are auxiliary material.
The amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：1).
The amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is
SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ(SEQID NO：2).
The amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
The concentration of enterococcus faecium is 2 × 10 in the enterococcus faecium agent9CFU/g。
The formula of the auxiliary material is：54% cassiri, 32.5% yeast culture, 10% fermented bean dregs, 0.3% are answered
Vitamin, 0.2% mineral element additive, 1.5% zeolite powder, 1.5% calcium monohydrogen phosphate are closed, the percentage is quality percentage
Number.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
<110>Jiangsu Shang Bao animal husbandry Co., Ltd
Guangzhou Glam Biotechnology Co., Ltd.
<120>A kind of pre-mixing feed additive for improving sow reproductive performance
<130>
<160> 3
<170> PatentIn version 3.5
<210> 1
<211> 14
<212> PRT
<213>Artificial sequence
<400> 1
Lys Gly Arg Gly Lys Gln Gly Gly Lys Val Arg Lys Ser Ser
1 5 10
<210> 2
<211> 33
<212> PRT
<213>Artificial sequence
<400> 2
Ser His Ile Ser Cys Gly Glu Ala Leu His Lys Cys Met Ala Ser His
1 5 10 15
Ser Lys Pro Phe Ser Cys Ser Cys Lys Phe His Met Tyr Leu Gln Gln
20 25 30
Gln
Claims (7)
1. a kind of pre-mixing feed additive, it is characterised in that：Feed addictive percentage meter by weight contains following components：
0.5%~10% Catfish antimicrobial peptide mutant, 0.5%~10% sea hare antibacterial peptide mutant Da-B2M, 0.5%~10% tobacco
Hawkmoth antibacterial peptide mutant Ms-mcM and 0.5%~10% enterococcus faecium agent；
The amino acid sequence of the Catfish antimicrobial peptide mutant is KGRGKQGGKVRKSS (SEQID NO：1)；
The amino acid sequence of the sea hare antibacterial peptide mutant Da-B2M is SHISCGEALHKCMASHSKPFSCSCKFHMYLQQQ
(SEQID NO：2)；
The amino acid sequence of the maduca sexta antibacterial peptide mutant Ms-mcM is
GKIPIGAIKQAGKAIGKGLRAINIASTTHDVVSFFRPKKKRH(SEQID NO：3).
2. a kind of pre-mixing feed additive according to claim 1, it is characterised in that：The feed addictive is by weight
Percentage meter contains following components：0.5%~10% Catfish antimicrobial peptide mutant, 0.5%~10% sea hare antibacterial peptide mutant Da-
B2M, 0.5%~10% maduca sexta antibacterial peptide mutant Ms-mcM, 0.5%~10% enterococcus faecium agent, surplus is auxiliary material.
3. a kind of pre-mixing feed additive according to claim 2, it is characterised in that：The feed addictive is by weight
Percentage meter contains following components：2.0%~6.0% Catfish antimicrobial peptide mutant, 1.0%~2.0% sea hare antibacterial peptide mutant
Da-B2M, 1.0%~2.0% maduca sexta antibacterial peptide mutant Ms-mcM, 0.5%~10% enterococcus faecium agent, supplemented by surplus
Material.
4. a kind of pre-mixing feed additive according to claim 3, it is characterised in that：The Catfish antimicrobial peptide mutation
The mass ratio of body, sea hare antibacterial peptide mutant Da-B2M and maduca sexta antibacterial peptide mutant is 4:1:1.
5. a kind of pre-mixing feed additive according to claim 1, it is characterised in that：The feed addictive is by weight
Percentage meter contains following components：4.0% Catfish antimicrobial peptide mutant, 1.0% sea hare antibacterial peptide mutant Da-B2M, 1.0% cigarette
Careless hawkmoth antibacterial peptide mutant Ms-mcM, 0.5% enterococcus faecium agent and 93.5% auxiliary material.
6. according to a kind of any pre-mixing feed additive of claim 2~5, it is characterised in that：The enterococcus faecium
The concentration of enterococcus faecium is 2 × 10 in agent9~3 × 109CFU/g。
7. according to a kind of any pre-mixing feed additive of claim 2~5, it is characterised in that：The auxiliary material contains
At least one of antioxidant, multi-vitamins, mineral element additive, cassiri, yeast culture, zeolite powder.
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