CN106256375A - A kind of efficiently Traditional Chinese Drug Anticancer product and preparation method thereof, using method and application - Google Patents
A kind of efficiently Traditional Chinese Drug Anticancer product and preparation method thereof, using method and application Download PDFInfo
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- CN106256375A CN106256375A CN201610924856.7A CN201610924856A CN106256375A CN 106256375 A CN106256375 A CN 106256375A CN 201610924856 A CN201610924856 A CN 201610924856A CN 106256375 A CN106256375 A CN 106256375A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/898—Orchidaceae (Orchid family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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Abstract
The present invention relates to a kind of efficiently Traditional Chinese Drug Anticancer product and preparation method thereof, using method and application, described efficient Traditional Chinese Drug Anticancer product, for by being spray-dried the Instant Chinese medicine powder process or powder prepared, wherein many effective antitumor compositions containing all kinds of Chinese medicines, do not contain or few containing that do not have anti-cancer function, to have potential drug toxicity invalid components；Classification is decocted medicinal herbs and is processed and use the drying process with atomizing of excipient to combine by the preparation method of the described efficient Traditional Chinese Drug Anticancer product that the present invention provides, apply in the production of Traditional Chinese Drug Anticancer product, and combine the using method of optimization, improve the dissolubility of this product, human absorptivity, active constituent content and medicinal curative effect, reduce this product toxicity to human body, be with a wide range of applications.
Description
Technical field
The present invention relates to pharmaceutical technology field, be specifically related to a kind of efficiently Traditional Chinese Drug Anticancer product and preparation method thereof, use
Methods and applications.
Background technology
Anticancer herbal drug is the animals and plants product that a class contains anticancer component, and its anticancer component can be by neutralizing carcinogen
Matter, the immune system that strengthens, prevent cancer angiogenesis, prevent that inflammation is carcinogenic, make the mechanism such as suicide of cancer cell, it is achieved to cancer, swollen
The preventing and treating of tumor.More than 300 kind main flows recorded by existing document " anticancer herbal drug " (Chemical Industry Press publishes for 2008)
Anticancer herbal drug, including warming the meridian removing food stagnancy, righting qi-restoratives, eliminating phlegm dissipating bond, blood circulation promoting and blood stasis dispelling, treating the poisonous disease with poisonous drugs, the big apoplexy due to endogenous wind of heat-clearing and toxic substances removing six
Medicine, and detail anticancer mechanism and the performance curative effect of every kind of medicine.
Prior art has been recorded the traditional preparation methods of plurality of Chinese antineoplastic product, such as a kind of anticancer traditional Chinese medicinal composition and
Its preparation method (application number CN200410018779.6), a kind of anticancer traditional Chinese medicinal composition, preparation method and applications (application number
CN201310507429.5), these Traditional Chinese Drug Anticancer products are all by Chinese medicine culinary art extraction, the drying of medicine soup, the step of grinding flour
Produce, have technique advantage simple, low-cost, but owing to anticancer component most of in Chinese medicine is slightly soluble or is insoluble in water,
Traditional Chinese Drug Anticancer product prepared by this method is difficult to be absorbed by human body, though taking medicine in a large number, curative effect is little.
In order to improve the human body absorbance to Chinese medicine antineoplastic product, prior art is by improving medicine spray drying technology
(U.S. Patent number US5976574A) disclose a kind of Chinese medical spray drier unit (application number CN201310382938.X) and
A kind of Chinese medicine extract that reduces is spray-dried the method (application number CN201310675856.4) of supplementary product consumption, being combined after concentration
Chinese medicines soup is prepared as Traditional Chinese Drug Anticancer product by the method being spray-dried, and owing to drug particles is less, degree of crystallinity is relatively low, has
Advantage soluble in water, that be easily absorbed by the body, is current state-of-the-art production technology；But this type of Traditional Chinese Drug Anticancer product is due to composition
Many and miscellaneous, cause the anticancer component ratio contained in unit pill relatively low, need to once take many pills and can reach preferable treatment
Effect, and " being three points of poison of medicine ", if long-term taking heavy dose medical material, the ingredient of other the non-antitumaous effects wherein contained can be right
The healthy of patient causes relatively major injury.
Therefore, seek novel efficient Traditional Chinese Drug Anticancer product, to improve the dissolubility of tcm product, human absorptivity, to have
Effective component content and anticancer therapeutic, reduce the tcm product toxicity to human body, is the problem being currently needed for solving.
Summary of the invention
For defect of the prior art, present invention aim at providing a kind of efficiently Traditional Chinese Drug Anticancer product and preparation side thereof
Method, using method and application, to improve the dissolubility of tcm product, human absorptivity, active constituent content and anticancer therapeutic, fall
The low tcm product toxicity to human body.
For achieving the above object, the technical scheme that the present invention provides is:
First aspect, the invention provides a kind of efficiently Traditional Chinese Drug Anticancer product, for by being spray-dried the Instant Chinese medicine prepared
Powder process or powder, wherein many effective antitumor compositions containing all kinds of Chinese medicines, without or few containing do not have anti-cancer function, have potential
The invalid components of drug toxicity.
Owing to described efficient Traditional Chinese Drug Anticancer product has instant, quickly can be dissolved or dispersed in water, improve
The human body absorption efficiency to medicine；And it is much lower compared to traditional product to the toxicity of human body, even if heavy dose of clothes
Health also will not be caused the biggest injury by medicine.
Second aspect, the invention provides the preparation method of a kind of efficient Traditional Chinese Drug Anticancer product, it is characterised in that include as
Lower step: prepare medical material；Decoct medicinal herbs (hot ultrasonic extraction)；Medicine soup is spray-dried；Moulding, packaging.
In the further embodiment of the present invention, preparing medical material used in described efficient Traditional Chinese Drug Anticancer product process is tool
There are anti-curing cancers, the animals and plants of tumor function and extract thereof, including detoxicating and fighting cancer type Chinese herbal medicine, hard masses softening and resolving anti-cancer type medium-height grass
Medicine, blood circulation promoting and blood stasis dispelling type anticancer herbal drug, the anti-cancer type Chinese herbal medicine that reduces phlegm, promoting diuresis to eliminate damp pathogen anti-cancer type Chinese herbal medicine, right supporting anticancer type medium-height grass
Medicine, analgesic anticarcinogen type Chinese herbal medicine, hemostasis anti-cancer type, anticancer food materials and beverage.
In the further embodiment of the present invention, prepare decocting medicinal herbs employed in described efficient Traditional Chinese Drug Anticancer product process
Method is hot ultrasonic extraction method, different anticancer components based on all kinds of Chinese medicines, the most molten to all kinds of Chinese medicines with water or organic solvent
Make medicine soup；Temperature of decocting medicinal herbs is preferably 20 ~ 100 degree, and ultrasonic intensity is preferably 20 ~ 60 hertz.
In the further embodiment of the present invention, prepare in described efficient Traditional Chinese Drug Anticancer product process be spray-dried enter
Material solution is the mixing Chinese medicines soup adding edible excipient；Described edible excipient is preferably saccharide, class sugar alcohol, ammonia
One or more in base acid, protein, milk powder, milk surum, coffee, and mass fraction in the feed solution is preferably 5 ~ 20%；
The temperature of described spray drying arranges and is preferably 120 ~ 250 degree.
In the further embodiment of the present invention, prepare in described efficient Traditional Chinese Drug Anticancer product process, described in be shaped to
Tablet, pill, capsule, red medicine or the form of medicament is made by being spray-dried the particle powder prepared.
The preparation method of the efficient Traditional Chinese Drug Anticancer product that the present invention provides, first classification is decocted medicinal herbs process and utilization excipient
Drying process with atomizing combine, apply in the production of Traditional Chinese Drug Anticancer product.Classification process of decocting medicinal herbs is by different condition
Under all kinds of Chinese medicines carried out medicine soup boil, (include water solublity, fat-soluble, water according to the different effective antitumor compositions of all kinds of Chinese medicines
The double soluble substance of fat), preferably go out and beneficially dissolve the temperature of decocting medicinal herbs with the effective Chinese medicine ingredients of anti-cancer function, such as 20 degree of cold water
(dissolving inorganic salt and water-soluble saccharides material), 60 degree of hot water (dissolving major part water-soluble substances), 100 degree of boiled water (dissolve absolutely
Major part water-soluble substances, dispersion part liposoluble substance)；And use beneficially dissolving to have the effective Chinese medicine ingredients of anti-cancer function
Secondary solvent, as 30% ethanol (dissolve or disperse the overwhelming majority water, liposoluble substance), 100% ethanol (dissolve major part liposoluble
Property material), 50% methanol (dissolve or disperse the overwhelming majority water, liposoluble substance)；And it is scattered not with material to use acceleration to dissolve
With vibration of ultrasonic wave frequency, such as 20 hertz (accelerating dissolve and disperse the insoluble material of small part), 40 hertz (rapid solution also divides
Dissipate the insoluble material of part), 60 hertz (dissolve and disperse most of insoluble material at a high speed)；Decoct medicinal herbs to process due to classification and remove
Non-anticancer Chinese medicine ingredients, effective antitumor composition in the efficient Traditional Chinese Drug Anticancer product of preparation has higher drug level and very
Low drug toxicity, has fully demonstrated for Chinese medicine compares Western medicine, the feature that the gentleness having is cured the disease.Use the spraying of excipient
Back tender artistic skill by change the kind of excipient and concentration control the degree of crystallinity of described efficient Traditional Chinese Drug Anticancer product, dissolubility,
Product design, reaches to control human absorptivity and the performance effects of described efficient Traditional Chinese Drug Anticancer product, and wherein saccharide, class sugar alcohol are composed
Shape agent can strengthen the water solublity of product by reducing degree of crystallinity, and aminoacid, protein excipient can be by reducing product thickness
Degree increases product yield, and milk powder, milk surum, coffee excipient are owing to rich in saccharide and protein, energy reinforced partly product is water-soluble
Property and yield；And excipient is added the mixing medicine soup of dissolution, prepare the armorphous of high degree of mixing by drying process with atomizing
Drug particles, the most each effective ingredient can be uniformly dispersed in product particle, beneficially uniform pickup and utilization, further
Ensure effect of described efficient Traditional Chinese Drug Anticancer product.
Use the preparation method of efficient Traditional Chinese Drug Anticancer product that the present invention provides, decocted medicinal herbs processs, interpolation excipient by classification
Agent, the technological process of spray drying, improve the dissolubility of this tcm product, human absorptivity, active constituent content and anticancer
Curative effect, reduces the tcm product toxicity to human body.
The third aspect, the invention provides the using method of a kind of efficient Traditional Chinese Drug Anticancer product, it is characterised in that: at non-NULL
In the case of abdomen, described efficient Traditional Chinese Drug Anticancer product is directly swallowed or taken after mixing it with water.
Owing to each composition of described efficient Traditional Chinese Drug Anticancer product is presented in non-crystalline or low crystalline state, and uniformly
Distribution, the described efficient Traditional Chinese Drug Anticancer product after taking can in digestive system rapid solution, and absorb；It should be noted that
Owing to the effective antitumor composition (such as gingerol, indole-alcohol, carnosol) in a lot of Chinese medicines is taken can more have with food
The utilization that is absorbed by the body of effect ground, the most preferably, should after the meal or after edible dessert, energy drink, take described efficient Traditional Chinese Drug Anticancer
Product.
The using method of the efficient Traditional Chinese Drug Anticancer product of present invention offer is provided, utilizes described efficient Traditional Chinese Drug Anticancer product
High-dissolvability, high effective ingredient concentration, take opportunity by preferred medicine, improves the people of described efficient Traditional Chinese Drug Anticancer product
Body absorbance and anticancer therapeutic.
Fourth aspect, the efficient Traditional Chinese Drug Anticancer product that the present invention provides is in prophylaxis of cancer, control cancer, treatment cancer
Medical applications, and the medical applications on anti-inflammation, enhancing immunologic function, regulation metabolism.
The Traditional Chinese Drug Anticancer product that prior art produces for after mixing multiple material by decocting medicinal herbs, dry, pulverizing prepares, human body
Absorbance is low, and curative effect is poor, toxicity is relatively big, and efficient Traditional Chinese Drug Anticancer product prepared by the present invention, can be according to regulation and control preparation side
Method controls product active anticancer and treatment dynamics, it is adaptable to the medical applications in prophylaxis of cancer, the cancer that controls, treatment cancer,
Chinese herbal medicine owing to using has again other additional functions simultaneously, and efficient Traditional Chinese Drug Anticancer product prepared by the present invention is also applied for antibacterial
Antiinflammatory, the medical applications strengthened on immunologic function, regulation metabolism.
The additional aspect of the present invention and advantage will part be given in the following description, and part will become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Accompanying drawing explanation
Fig. 1 is the preparation method flow chart of efficient Traditional Chinese Drug Anticancer product in the embodiment of the present invention one.
Fig. 2 is the electron-microscope scanning figure of the efficient Traditional Chinese Drug Anticancer product prepared in the embodiment of the present invention two.
Fig. 3 is the electron-microscope scanning figure of the efficient Traditional Chinese Drug Anticancer product prepared in the embodiment of the present invention three.
Fig. 4 is the electron-microscope scanning figure of the efficient Traditional Chinese Drug Anticancer product prepared in the embodiment of the present invention four.
Fig. 5 is confocal scanning figure and the contrast pure lactose thereof of efficient Traditional Chinese Drug Anticancer product in the embodiment of the present invention five
X ray diffracting spectrum.
Fig. 6 is efficient Traditional Chinese Drug Anticancer product profile photo before and after tabletting in the embodiment of the present invention six.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Describe, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments wholely.Based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under not making creative work premise
Embodiment, broadly falls into the scope of protection of the invention.
Embodiment one
The present embodiment provides a kind of efficiently Traditional Chinese Drug Anticancer product, for by being spray-dried the Instant Chinese medicine powder process or medicine prepared
Grain, wherein many effective antitumor compositions containing all kinds of Chinese medicines, without or few containing do not have anti-cancer function, have potential drug toxicity
Invalid components.
For the efficient Traditional Chinese Drug Anticancer product of the present invention, the present invention devises the preparation side of this efficient Traditional Chinese Drug Anticancer product
Method:
Fig. 1 is the flow chart of the preparation method of the efficient Traditional Chinese Drug Anticancer product in the embodiment of the present invention, as it is shown in figure 1, the present invention
The preparation method of the efficient Traditional Chinese Drug Anticancer product provided, comprises the following steps:
S1: prepare medical material；
S2: decoct medicinal herbs (hot ultrasonic extraction)；
S3: medicine soup is spray-dried；
S4: moulding, packaging.
The preparation method of the efficient Traditional Chinese Drug Anticancer product provided the present invention below in conjunction with specific embodiment is made furtherly
Bright.
Embodiment two
Present embodiments provide the preparation method of a kind of efficient Traditional Chinese Drug Anticancer product, comprise the steps:
S1: weigh 50 grams of Rhizoma Atractylodis Macrocephalaes, 100 grams of Radix Asparagis, 100 grams of Thallus Laminariae (Thallus Eckloniae)s, 100 grams of Folium Eriobotryaes, 200 grams of Flos Loniceraes, 100 grams of green tea, point
After not shredding and grinding standby；
S2: the Rhizoma Atractylodis Macrocephalae, Radix Asparagi, Flos Lonicerae are carried out in 10 aqueous solution of 20 degree the ultrasonic Treatment 20 minutes of 20 hertz, abandons
After solution, change 10 liters of boiled water of 100 degree carry out the ultrasonic Treatment 40 minutes of 60 hertz, prepare suspension, solid-liquid separation
Rear acquisition medicine soup；Thallus Laminariae (Thallus Eckloniae), green tea are stirred 20 minutes in 10 aqueous solution of 60 degree, after reject solution, changes with the 10 of 100 degree
Rise in boiled water the ultrasonic Treatment 40 minutes carrying out 40 hertz, prepare suspension, after solid-liquid separation, obtain medicine soup；By Folium Eriobotryae 20
10 aqueous solution of degree carry out the ultrasonic Treatment 20 minutes of 20 hertz, after reject solution, changes 10 liters of drinks with 60 degree molten
Liquid (ethanol content is 30%) carries out the ultrasonic Treatment 40 minutes of 40 hertz, prepares suspension, after solid-liquid separation, obtain medicine soup；
S3: after the medicine soup mixing produced in above-mentioned steps, adding mass fraction is the lactalbumin powder of 10%, after stirring mixing,
It is spray-dried at a temperature of 150 degree, prepares the thick product powder of efficient Traditional Chinese Drug Anticancer product；
S4: by be spray-dried obtain thick product powder directly pack, be with medicated powder electuary form exist efficient in
Medicine antineoplastic product.
The Chinese medicine selected due to the present embodiment is to mainly contain anti-inflammation, the Chinese herbal medicine of vital base and primordial QI consolidating class anticancer component,
Obtained efficient Traditional Chinese Drug Anticancer product is preferably used for prophylaxis of cancer.
Embodiment three
Present embodiments provide the preparation method of a kind of efficient Traditional Chinese Drug Anticancer product, comprise the steps:
S1: weigh 40 grams of Radix Ginsengs, 80 Keshan Rhizoma sagittariae sagittifoliaes, 80 grams of Rhizoma Zingiberis Recenss, 100 grams of Herba Rosmarini Officinaliss, 100 grams of Hedyotidis Diffusaes, 100 grams of Poria,
100 grams of Herba Portulacae Grandifloraes, standby after shredding respectively and grinding；
S2: Radix Ginseng, Rhizoma Zingiberis Recens, Herba Rosmarini Officinalis are carried out in 10 liters of ethanol solution of 30 degree the ultrasonic Treatment 60 minutes of 60 hertz,
Prepare suspension, after solid-liquid separation, obtain medicine soup, dry for standby；Pseudobulbus Cremastrae Seu Pleiones, Hedyotidis Diffusae, Herba Portulacae Grandiflorae is water-soluble 10 liters of 60 degree
Liquid stirs 20 minutes, after reject solution, changes 10 liters of boiled water of 100 degree carry out the ultrasonic Treatment 40 minutes of 40 hertz,
Prepare suspension, after solid-liquid separation, obtain medicine soup；Poria is carried out in 10 aqueous solution of 20 degree the ultrasonic Treatment of 20 hertz
20 minutes, after reject solution, change 10 liters of drinks solution (ethanol content is for 10%) of 100 degree carry out the ultrasound wave of 50 hertz
Process 40 minutes, prepare suspension, after solid-liquid separation, obtain medicine soup；
S3: after the medicine soup mixing produced in above-mentioned steps, adds the brown sugar granule that mass fraction is 5%, after stirring mixing,
It is spray-dried at a temperature of 180 degree, prepares the thick product powder of efficient Traditional Chinese Drug Anticancer product；
S4: carry out pressing grain to process by being spray-dried the thick product powder obtained, be the efficient Traditional Chinese Medicine Anti existed with powder form
Cancer product.
The Chinese medicine selected due to the present embodiment is to mainly contain anticancer sterilization, the Chinese herbal medicine of right supporting anticancer class anticancer component,
Obtained efficient Traditional Chinese Drug Anticancer product is preferably used for controlling cancerous cell and the growth of tumor cell.
Embodiment four
Present embodiments provide the preparation method of a kind of efficient Traditional Chinese Drug Anticancer product, comprise the steps:
S1: weigh 10 grams of Calculus Boviss, 40 grams of Dioscorea bulbifera L.es, 80 Keshan Radix Sophorae Tonkinensis, 100 grams of Spica Prunellaes, 100 grams of Fructus Jujubaes, 100 grams of Herba Artemisiae Annuaes, 100 grams
Folium cordylines fruticosae, standby after shredding respectively and grinding；
S2: Calculus Bovis, Dioscorea bulbifera L., Herba Artemisiae Annuae are carried out in 10 liters of ethanol solution of 50 degree the ultrasonic Treatment 60 minutes of 50 hertz, system
Obtain suspension, after solid-liquid separation, obtain medicine soup, dry for standby；By Radix Sophorae Tonkinensis, Spica Prunellae, Folium cordylines fruticosae in 5 aqueous solution of 50 degree
The ultrasonic Treatment carrying out 20 hertz stirs 20 minutes, after reject solution, changes to carry out 60 hertz in 10 liters of boiled water of 100 degree
Ultrasonic Treatment 40 minutes, prepares suspension, obtains medicine soup after solid-liquid separation；Fructus Jujubae is carried out in 1 liter of ethanol solution of 60 degree
The ultrasonic Treatment of 30 hertz 20 minutes, after reject solution, changes the ultrasonic Treatment 40 carrying out 20 hertz in the hot water with 80 degree
Minute, prepare suspension, after solid-liquid separation, obtain medicine soup；
S3: after the medicine soup mixing produced in above-mentioned steps, adding mass fraction is the lactose granule of 15%, after stirring mixing,
It is spray-dried at a temperature of 160 degree, prepares the thick product powder of efficient Traditional Chinese Drug Anticancer product；
S4: mix being spray-dried the pure water of thick product powder homogenous quantities obtained, bottled after be with ointment shape
The efficient Traditional Chinese Drug Anticancer product that formula exists, is i.e. able to medicament after being diluted this toothpaste product with the pure water of 2 ~ 5 times of quality
The efficient Traditional Chinese Drug Anticancer product that form exists.
The Chinese medicine selected due to the present embodiment is to mainly contain anticancer dispersing tumor, the Chinese herbal medicine of hard masses softening and resolving class anticancer component,
Obtained efficient Traditional Chinese Drug Anticancer product is preferably used for edible shape Chinese medicine chemotherapy, middle and terminal cancer controls and treatment.
Microcosmic according to the efficient Traditional Chinese Drug Anticancer product that above-described embodiment two, embodiment three or embodiment four prepare
Grain somatometry of physique:
Fig. 2 is the electron-microscope scanning figure of the efficient Traditional Chinese Drug Anticancer product prepared in the embodiment of the present invention two；
Fig. 3 is the electron-microscope scanning figure of the efficient Traditional Chinese Drug Anticancer product prepared in the embodiment of the present invention three；
Fig. 4 is the electron-microscope scanning figure of the efficient Traditional Chinese Drug Anticancer product prepared in the embodiment of the present invention four.
Show at the electron-microscope scanning figure using the inventive method to record each efficient Traditional Chinese Drug Anticancer product, be prepared by embodiment two
The size of the efficient Traditional Chinese Drug Anticancer product particle obtained is between 1 ~ 20 micron, and profile is the granule caved in surface；In embodiment three
The size of the efficient Traditional Chinese Drug Anticancer product particle prepared is between 0.2 ~ 2 micron, and profile is spheroidal particle；Embodiment four is made
The size of the standby efficient Traditional Chinese Drug Anticancer product particle obtained is between 1 ~ 10 micron, and profile is spheroidal particle.
In the present invention, due to prepare in described efficient Traditional Chinese Drug Anticancer product process medical material used for have anti-curing cancers,
The animals and plants of tumor function and extract thereof, including detoxicating and fighting cancer type Chinese herbal medicine, hard masses softening and resolving anti-cancer type Chinese herbal medicine, blood circulation promoting and blood stasis dispelling
Type anticancer herbal drug, the anti-cancer type Chinese herbal medicine that reduces phlegm, promoting diuresis to eliminate damp pathogen anti-cancer type Chinese herbal medicine, right supporting anticancer type Chinese herbal medicine, analgesic anticarcinogen
Type Chinese herbal medicine, hemostasis anti-cancer type, anticancer food materials and beverage, all kinds of curative effects of these Chinese herbal medicine and medical mechanism are fully ground
Study carefully and be documented in " anticancer herbal drug " (Chemical Industry Press publishes for 2008) that Zhou Yiqiang et al. writes.
In the present invention, difference based on all kinds of anticancer herbal drugs (including water solublity, fat-soluble, the double soluble substance of water fat)
Physicochemical property and medical mechanism, the method for decocting medicinal herbs used is that classification based on hot ultrasonic extraction method is decocted medicinal herbs process, i.e. with water or
Organic solvent makes medicine soup to all kinds of Chinese medicines are the most molten, carries out being spray-dried goods after mixing again.Described classification decoct medicinal herbs process
Method is to boil by different conditions all kinds of Chinese medicines being carried out medicine soup, according to the different effective antitumor compositions of all kinds of Chinese medicines,
Preferably go out and beneficially dissolve the temperature of decocting medicinal herbs with the effective Chinese medicine ingredients of anti-cancer function, use and be conducive to dissolving to have anti-cancer function
The effectively secondary solvent of Chinese medicine ingredients, and use acceleration to dissolve and the scattered different vibration of ultrasonic wave frequencies of material, wherein decoct medicinal herbs
Temperature is preferably 20 ~ 100 degree, and ultrasonic intensity is preferably 20 ~ 60 hertz, and organic solvent is preferably ethanol (i.e. ethanol)；Due to
Classification process of decocting medicinal herbs eliminates non-anticancer Chinese medicine ingredients, and the effective antitumor composition in the efficient Traditional Chinese Drug Anticancer product of preparation has more
High drug level and the lowest drug toxicity, fully demonstrated for Chinese medicine compares Western medicine, the feature that the gentleness having is cured the disease.
It should be noted that, described classification is decocted medicinal herbs, temperature of decocting medicinal herbs, ultrasonic intensity, the organic solvent outlined in processing is preferred stripe
Part, uses other to decoct medicinal herbs temperature or ultrasonic intensity carrys out acceleration or deceleration medicine eduction rate, or uses other organic solvents to analyse
It is also feasible for going out non-water soluble substance, based on the present invention and only by simply changing the production technology of condition of making up a prescription all at this
Within bright protection domain.
In the present invention, preparing the feedstock solution being spray-dried in described efficient Traditional Chinese Drug Anticancer product process can for adding
The mixing Chinese medicines soup of edible excipient；Described edible excipient is preferably saccharide, class sugar alcohol, aminoacid, protein, milk
One or more in powder, milk surum, coffee, and mass fraction in the feed solution is preferably 5 ~ 20%；Baking temperature is preferably
120 ~ 250 degree.
Prepare in described efficient Traditional Chinese Drug Anticancer product process using the inventive method, it is notable that use figuration
The drying process with atomizing of agent can by change the kind of excipient and concentration control described efficient Traditional Chinese Drug Anticancer product degree of crystallinity,
Dissolubility, product design, reach to control human absorptivity and the performance effects of described efficient Traditional Chinese Drug Anticancer product, wherein saccharide,
Class sugar alcohol excipient can strengthen the water solublity of product by reducing degree of crystallinity, and aminoacid, protein excipient can be by reducing
Product viscosity increases product yield, and milk powder, milk surum, coffee excipient are due to rich in saccharide and protein, energy reinforced partly
Product water dissolubility and yield；And excipient is added the mixing medicine soup of dissolution, prepare high degree of mixing by drying process with atomizing
Armorphous drug particles, the most each effective ingredient can be uniformly dispersed in product particle, beneficially uniform pickup and profit
With, ensure effect of described efficient Traditional Chinese Drug Anticancer product further.Should be noted that for preparing described efficient Traditional Chinese Medicine Anti
The excipient of cancer product is not restricted to the above-mentioned kind preferably enumerated, and all can being used for prepares described efficient Traditional Chinese Drug Anticancer product
The edible excipient of middle spray drying link is all within protection scope of the present invention, and this includes lactose, sucrose, fructose, sweet
Dew sugar, starch, galactose, maltose, trehalose, glucose, ribose, xylose, fucose, rhamnose, arabinose, Pyrusussuriensis
Sugar, 6-(.alpha.-D-galactosido)-D-glucose., chitosan and carbohydrate derivative mannitol, Sorbitol, glucitol, xylitol, Polyethylene Glycol, Fructus Hordei Germinatus are stuck with paste
Essence, cyclodextrin, aminoacid, dextran, glucuronic acid, acetazolamide, polymethylacrylic acid, sodium cromoglicate, soybean polysaccharide, fibre
One or more in dimension element, cellulose esters, cellulose ether and other kinds aminoacid, protein, milk surum, milk powder, coffee；
And also it is not restricted to above-mentioned excellent for preparing the excipient of described efficient Traditional Chinese Drug Anticancer product mass fraction in the feed solution
The concentration that choosing is enumerated, by using lower mass fraction to reduce the water solublity of described efficient Traditional Chinese Drug Anticancer product, or passes through
Use higher mass fraction to increase the water solublity of described efficient Traditional Chinese Drug Anticancer product, be all feasible；Described for preparing
Efficiently the spray drying temperature of Traditional Chinese Drug Anticancer product is also not restricted to the above-mentioned temperature range preferably enumerated, lower by using
Temperature reduces the degree of crystallinity of described efficient Traditional Chinese Drug Anticancer product or increases water content, or by using higher temperature to increase
The degree of crystallinity of described efficient Traditional Chinese Drug Anticancer product, is all feasible.
In the present invention, prepare be shaped to described in described efficient Traditional Chinese Drug Anticancer product process by be spray-dried prepare
Grain powder makes tablet, pill, capsule, red medicine or the form of medicament.
Use the preparation method of efficient Traditional Chinese Drug Anticancer product that the present invention provides, decocted medicinal herbs processs, interpolation excipient by classification
Agent, the technological process of spray drying, improve the dissolubility of this tcm product, human absorptivity, active constituent content and anticancer
Curative effect, reduces the tcm product toxicity to human body.
For the efficient Traditional Chinese Drug Anticancer product of the present invention, the present invention devises the user of this efficient Traditional Chinese Drug Anticancer product
Method, it is characterised in that: in the case of non-empty stomach, described efficient Traditional Chinese Drug Anticancer product is directly swallowed or taken after mixing it with water.
The using method of the efficient Traditional Chinese Drug Anticancer product provided the present invention below in conjunction with specific embodiment is made furtherly
Bright.
Embodiment five
Present embodiments provide the using method of a kind of efficient Traditional Chinese Drug Anticancer product, it is characterised in that: in the case of non-empty stomach,
The efficient Traditional Chinese Drug Anticancer product with medicine type existence prepared in example four is directly taken.
Fig. 5 is confocal scanning figure and the contrast pure lactose thereof of efficient Traditional Chinese Drug Anticancer product in the embodiment of the present invention five
X ray diffracting spectrum.
In the using method test studying described efficient Traditional Chinese Drug Anticancer product further, drug particles after spray drying
Confocal scanning figure shows that effective ingredient is all wrapped in inside spheroidal particle by excipient, and such form is conducive to
Drug particles transmission in intestinal tract, is beneficial to digest and assimilate, and the figuration oxidant layer on surface is glucide, pleasantly sweet, side
It is easy to anhydrous oral.
In the using method test studying described efficient Traditional Chinese Drug Anticancer product further, drug particles after spray drying
The X ray diffracting spectrum of contrast pure lactose shows, each composition of described efficient Traditional Chinese Drug Anticancer product is with non-crystalline or low crystallization
Presented in state, and be uniformly distributed, then the described efficient Traditional Chinese Drug Anticancer product after taking can in digestive system rapid solution,
And absorb.
Based on the studies above, when the using method of the efficient Traditional Chinese Drug Anticancer product using the present invention to provide, merit attention
, owing to the effective antitumor composition (such as gingerol, indole-alcohol, carnosol) in a lot of Chinese medicines takes energy with food
More effectively be absorbed by the body utilization, the most preferably, and should after the meal or after edible dessert, energy drink, take described efficient Chinese medicine
Antineoplastic product；Certainly, (medicine) being taken before meal with or take by other means (as respiratory system take in, skin take in, injection) being also can
Row.
Embodiment six
Present embodiments provide the using method of a kind of efficient Traditional Chinese Drug Anticancer product, it is characterised in that: by what example two prepared
The efficient Traditional Chinese Drug Anticancer product existed with powder form passes through to carry out tabletting process under 1ton pressure, more directly swallows.
Fig. 6 is efficient Traditional Chinese Drug Anticancer product profile photo before and after tabletting in the embodiment of the present invention six.
Generally, the described efficient Traditional Chinese Drug Anticancer product with powder form existence of taking after mixing it with water can reach preferably to absorb
Efficiency, but medicated powder can be made can directly to swallow or chew clothes by the tabletting of medicated powder is processed, it is simple to carry, convenient；Again
Owing to the existence of excipient makes tablet have certain sweet taste, the when of oral, do not have the sensation of bitterness.
The using method of the efficient Traditional Chinese Drug Anticancer product of present invention offer is provided, utilizes described efficient Traditional Chinese Drug Anticancer product
High-dissolvability, high effective ingredient concentration, take opportunity by preferred medicine, improves the people of described efficient Traditional Chinese Drug Anticancer product
Body absorbance and anticancer therapeutic.
Embodiment seven
The present embodiment provides the medical treatment in prophylaxis of cancer, control cancer, treatment cancer of the described efficient Traditional Chinese Drug Anticancer product
Application, and the medical applications on anti-inflammation, enhancing immunologic function, regulation metabolism.
The Traditional Chinese Drug Anticancer product that prior art produces for after mixing multiple material by decocting medicinal herbs, dry, pulverizing prepares, human body
Absorbance is low, and curative effect is poor, toxicity is relatively big, and efficient Traditional Chinese Drug Anticancer product prepared by the present invention, can be according to regulation and control preparation side
Method controls product active anticancer and treatment dynamics, it is adaptable to the medical applications in prophylaxis of cancer, the cancer that controls, treatment cancer,
Chinese herbal medicine owing to using has again other additional functions simultaneously, and efficient Traditional Chinese Drug Anticancer product prepared by the present invention is also applied for antibacterial
Antiinflammatory, the medical applications strengthened on immunologic function, regulation metabolism.
Although above it has been shown and described that embodiments of the invention, it is to be understood that above-described embodiment is example
Property, it is impossible to being interpreted as limitation of the present invention, those of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, revises, replaces and modification, and does not make the essence of appropriate technical solution depart from various embodiments of the present invention skill
The scope of art scheme, it all should be contained in the middle of the claim of the present invention and the scope of description.
Claims (8)
1. an efficient Traditional Chinese Drug Anticancer product, it is characterised in that: described efficient Traditional Chinese Drug Anticancer product, for prepared by being spray-dried
Instant Chinese medicine powder process or powder, wherein many effective antitumor compositions containing all kinds of Chinese medicines, without or few anticancer containing not having
Function, the invalid components that has potential drug toxicity.
The preparation method of efficient Traditional Chinese Drug Anticancer product the most according to claim 1, it is characterised in that comprise the steps:
Prepare medical material；Decoct medicinal herbs (hot ultrasonic extraction)；Medicine soup is spray-dried；Moulding, packaging.
The preparation method of efficient Traditional Chinese Drug Anticancer product the most according to claim 2, it is characterised in that: described medical material is for having
Anti-curing cancers, the animals and plants of tumor function and extract thereof, including detoxicating and fighting cancer type Chinese herbal medicine, hard masses softening and resolving anti-cancer type medium-height grass
Medicine, blood circulation promoting and blood stasis dispelling type anticancer herbal drug, the anti-cancer type Chinese herbal medicine that reduces phlegm, promoting diuresis to eliminate damp pathogen anti-cancer type Chinese herbal medicine, right supporting anticancer type medium-height grass
Medicine, analgesic anticarcinogen type Chinese herbal medicine, hemostasis anti-cancer type, anticancer food materials and beverage.
The preparation method of efficient Traditional Chinese Drug Anticancer product the most according to claim 2, it is characterised in that decoct medicinal herbs described in: as using
Hot ultrasonic extraction method, different anticancer components based on all kinds of Chinese medicines, make medicine with water or organic solvent to all kinds of Chinese medicines are the most molten
Soup；Temperature of decocting medicinal herbs is preferably 20 ~ 100 degree, and ultrasonic intensity is preferably 20 ~ 60 hertz.
The preparation method of efficient Traditional Chinese Drug Anticancer product the most according to claim 2, it is characterised in that: described spray drying
Feedstock solution is to add the mixing Chinese medicines soup of edible excipient；Described edible excipient be preferably saccharide, class sugar alcohol,
One or more in aminoacid, protein, milk powder, milk surum, coffee, and mass fraction in the feed solution be preferably 5 ~
20%；Baking temperature is preferably 120 ~ 250 degree.
The preparation method of efficient Traditional Chinese Drug Anticancer product the most according to claim 2, it is characterised in that be shaped to described in: to spray
Mist is dried prepared particle powder and makes tablet, pill, capsule, red medicine or the form of medicament.
The using method of efficient Traditional Chinese Drug Anticancer product the most according to claim 1, it is characterised in that: in the situation of non-empty stomach
Under, described efficient Traditional Chinese Drug Anticancer product is directly swallowed or taken after mixing it with water.
The efficient Traditional Chinese Drug Anticancer product the most according to claim 1 medical treatment in prophylaxis of cancer, control cancer, treatment cancer
Application, and the medical applications on anti-inflammation, enhancing immunologic function, regulation metabolism.
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Citations (2)
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| WO2012123502A1 (en) * | 2011-03-15 | 2012-09-20 | Lek Pharmaceuticals D.D. | A novel process of residual solvent removal |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012123502A1 (en) * | 2011-03-15 | 2012-09-20 | Lek Pharmaceuticals D.D. | A novel process of residual solvent removal |
| CN105456311A (en) * | 2014-09-30 | 2016-04-06 | 中山未标生物新技术有限公司 | Hippophae rhamnoides extract for preventing and treating breast cancer and liver cancer as well as preparation method and application of hippophae rhamnoides extract |
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