CN1062466A - A kind of preparation method of NUANQIGAO - Google Patents

Abstract

What the present invention described is that a kind of lanoline that adopts is the method that substrate prepares NUANQIGAO, has changed the technology of traditional preparation plaster.Having overcome middle pharmaceutically active ingredient aborning is damaged and the loaded down with trivial details characteristics of technology, the main technique flow process is: technology preparation → with ethanol extraction, merging filtrate → make fluid extract, add Moschus fine powder mixing, lanoline and octadecanol adding starch medicated powder are stirred, add ethanol stream extractum again and stir → be yellow-yellowish-brown ointment, the stand is coated in natural cooling on the disinfectant polyethylene mounting media.

Description

A kind of preparation method of NUANQIGAO

The invention discloses a kind of preparation method of NUANQIGAO, this method adopt lanoline, octadecanol be substrate to have substituted black plaster be substrate with vegetable oil and Plumbum preparatium, the product of this method is between black plaster and rubber plaster.

All use conventional methods in the prior art and produce black plaster and rubber unguentum.Black plaster is with vegetable oil, Plumbum preparatium (Pb ₃O ₄) temper for raw material and to form, main technique is with medical material fried withered extraction in the vegetable oil of 240 ℃ of high temperature, the vegetable oil that removes slag is continued heating temper, and temperature is controlled at 270-300 ℃, drip into pearl and do not loose to getting a little, oil refining add the Plumbum preparatium temperature be not less than 270 ℃ to denseness suitably promptly.

The shortcoming of black plaster is the fried thing of getting it filled of megistotherm, and the effective ingredient of medicine is destroyed and loss easily, and oil refining process also is not easy control, temperature reaches more than 300 ℃ in the process of tempering, easily catch fire, produce a large amount of dense smokes and irritative gas simultaneously, cause air pollution.In black plaster used, often skin being produced stimulated, and erythema gently then occurs, scratches where it itches, the heavy then ulcer that foams; Need thermoplastic to use before using in addition.

2, rubber unguentum is with rubber and Colophonium, oil material and plant mixing such as filling agent and make substrate, or with medicament mixed after be evenly coated in and mount the backing material.

Purpose of the present invention discloses a kind of method that adopts new substrate to prepare NUANQIGAO, its technology is simple, without high-temperature process, do not destroy effective ingredient, good effect, skin do not had allergy, nonirritant.

Technical scheme of the present invention is:

Use ointment base-lanoline, preserved a large amount of middle pharmaceutically active ingredients in the preparation, pharmaceutical formulation novelty-yellow-yellowish-brown, no greasy feeling does not dye medicated clothing, and accompanying drawing 1 is seen in its technological process.

Adopt following technology preparation:

(1) the crude drug prescription is: Radix Angelicae Sinensis 80g, Radix Angelicae Dahuricae 80g, Radix Linderae 80g, Fructus Foeniculi 80g, Fructus Anisi Stellati 80g, Radix Aucklandiae 40g, Rhizoma Cyperi 80g, Olibanum 20g, Fructus Caryophylli 20g, Myrrha 20g, Cortex Cinnamomi 20g, Lignum Aquilariae Resinatum 20, Moschus 3g;

(2) technology preparation: lanoline 3-8% octadecanol 0.2-3% starch 1-6%

Ethanol stream extractum 0.1-1%.

Adopt following program: substrate is that lanoline, octadecanol, additive are starch flow extractum, and the reaction condition temperature is controlled at 60-90 ℃ of pressure normal pressure; Reinforced order can be described as:

At first with Olibanum, Fructus Caryophylli, Myrrha, Radix Aucklandiae powder is broken into fine powder and crosses 100 mesh sieves, mixing with it after again Moschus being ground, then with Radix Angelicae Sinensis, Radix Angelicae Dahuricae cream, Fructus Foeniculi, Fructus Anisi Stellati, Rhizoma Cyperi, Cortex Cinnamomi, Lignum Aquilariae Resinatum is given as one thinks fit cataclasm, use the 70-90% ethanol extraction, merging filtrate reclaims ethanol, make the fluid extract that 20ml contains the 100g crude drug, at last with the lanoline octadecanol in water-soluble down heat fused, temperature is controlled at 60-90 ℃ and adds starch, medicated powder stirs, ethanol stream extractum is added fully stirring formation yellow-filemot ointment, this ointment stand is coated in natural cooling on the disinfectant polyethylene mounting media.

Good effect of the present invention: can analyze from the raw material that adopts:

Lanoline is the ester that higher fatty acids and higher alcohol chemical combination form, and its physical property and fat have similarity.Because the Skin Cell film is a lipoid, lanoline character is near sebum, good because of lanoline again to the skin closure, can stop the evaporation of perspiration and moisture of skin, form suitable water balance at skin surface, promote the skin hydration effect, can increase the permeability of skin, thereby lanoline helps medicine and penetrates skin and absorption, makes medicine give full play to drug effect.

The sensitization of lanoline extremely a little less than, nonirritant, safe and reliable.

Novel NUANQIGAO adopts modern ointment processing technology, and lanoline is heated in water temperature, adds other adjuvants and medicine, without high-temperature process, does not destroy the effective ingredient of medicine, and technology is simple, convenient for production.

In use, vacuum response does not have irritated phenomenon, and no greasy feeling does not pollute clothes and skin.

Accompanying drawing 1 is a process chart of the present invention.

Embodiment: (the best)

1, Olibanum, Fructus Caryophylli, Myrrha, Radix Aucklandiae powder are broken into fine powder, cross 100 mesh sieves, after again Moschus being ground, mixing also.

2, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Radix Linderae, Fructus Foeniculi, Fructus Anisi Stellati, Rhizoma Cyperi, Cortex Cinnamomi, Lignum Aquilariae Resinatum are given as one thinks fit cataclasm, use 80% ethanol extraction, merging filtrate reclaims ethanol, makes the fluid extract that 20ml contains 100g.

3, lanoline, octadecanol heat fused, temperature under water temperature are controlled at 75 ℃, add starch, medicated powder, stir, ethanol stream extractum is added, fully stir, form yellow-filemot ointment; This ointment stand is coated on the disinfectant polyethylene mounting media, natural cooling, every cream weight 2-15g contains crude drug 1-6g.

Claims (2)

1, a kind of lanoline that utilizes prepares the method for NUANQIGAO for substrate, described method with Pilus Caprae seu Ovis refer to, octadecanol replace black plaster is substrate with vegetable oil and Plumbum preparatium, it is characterized in that adopting following technological process:

Adopt following technology preparation:

(4) the crude drug prescription is: Radix Angelicae Sinensis 80g, Radix Angelicae Dahuricae 80g, Radix Linderae 80g, Fructus Foeniculi 80g, Fructus Anisi Stellati 80g, Radix Aucklandiae 40g, Rhizoma Cyperi 80g, Olibanum 20g, Fructus Caryophylli 20g, Myrrha 20g, Cortex Cinnamomi 20g, Lignum Aquilariae Resinatum 20, Moschus 3g;

(5) technology preparation: lanoline 3-8% octadecanol 0.2-3% starch 1-6% ethanol stream extractum 0.1-1%.

2, according to the preparation method of the described a kind of NUANQIGAO of claim 1, it is characterized in that adopting following program: substrate is that lanoline, octadecanol, additive are starch flow extractum, and the reaction condition temperature is controlled at 60-90 ℃ of pressure normal pressure; Reinforced order can be described as:

At first with Olibanum, Fructus Caryophylli, Myrrha, Radix Aucklandiae powder is broken into fine powder and crosses 100 mesh sieves, mixing with it after again Moschus being ground, then with Radix Angelicae Sinensis, Radix Angelicae Dahuricae cream, Fructus Foeniculi, Fructus Anisi Stellati, Rhizoma Cyperi, Cortex Cinnamomi, Lignum Aquilariae Resinatum is given as one thinks fit cataclasm, use the 70-90% ethanol extraction, merging filtrate reclaims ethanol, make the fluid extract that 20ml contains the 100g crude drug, at last with the lanoline octadecanol in water-soluble down heat fused, temperature is controlled at 60-90 ℃ and adds starch, medicated powder stirs, ethanol stream extractum is added fully stirring formation yellow-filemot ointment, this ointment stand is coated in natural cooling on the disinfectant polyethylene mounting media.

Images