CN106237108A - The formula of a kind of compound bee-glue and preparation method - Google Patents

The formula of a kind of compound bee-glue and preparation method Download PDF

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CN106237108A
CN106237108A CN201610692541.4A CN201610692541A CN106237108A CN 106237108 A CN106237108 A CN 106237108A CN 201610692541 A CN201610692541 A CN 201610692541A CN 106237108 A CN106237108 A CN 106237108A
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parts
fructus
rhizoma polygonati
lycii
glue
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刘晓龙
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Insects & Arthropods (AREA)
  • Animal Husbandry (AREA)
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  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

The invention discloses formula of a kind of compound bee-glue and preparation method thereof, be made up of following raw material: propolis, thioctic acid, L arabinose part, Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati.Its preparation method is: first propolis, thioctic acid, L arabinose are ground into powder；Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati are extracted by recycling water extraction；Finally the powder crushed in step 1 mixed with the extract of step 2 and make pharmaceutical dosage form.The present invention many employings Chinese herbal medicine is raw material, wide material sources, low price, can effectively control the development of diabetes, and have no side effect.

Description

The formula of a kind of compound bee-glue and preparation method
Technical field
The present invention relates to formula and the preparation method of a kind of compound bee-glue, belong to health food and field of medicaments.
Background technology
China is diabetes big countries, is the most all the hat in the whole world on diabetes population absolute number, China 18 years old and More than in adult's sample, it is 11.6% according to the diabetes estimation prevalence that international up-to-date clinical criteria carries out diagnosing, so And, although China's health of the masses consciousness had strengthened in recent years, but diabetics number quickly increases this trend and do not obtains Change to essence.Estimate according to International Diabetes Federation before, now the total diabetics more than 300,000,000 in the whole world, The new diabetes mellitus in China sickness rate data issued mean that the diabetes patient in the whole world 1/3rd is from China.About three points of China Two diabetics do not carry out enough glycemic control.Thus cause the appearance of diabetic complication.
Water extraction i.e. " decocting method ", is to add water medical material to boil the method for extracting juice.This method is that the one early used is simple most Leaching method, is still preparation so far and leaches preparation most common method.Also it is to prepare part powder, pill, tablet, granule simultaneously Agent and one of injection or the basic skills extracting some effective ingredient.
The diabetics many employings insulin injection made a definite diagnosis or the medicine taking blood sugar lowering class are to control blood glucose and glucose in urine Index, both approaches easily makes people form dependency, easily recurs after drug withdrawal, and Drug therapy exists certain secondary work With.
Summary of the invention
For solving an above existing difficult problem, the invention discloses formula and the preparation method of a kind of compound bee-glue, raw material is adopted more It is raw material with Chinese medicine, wide material sources, low price, and have no side effect.
The formula of a kind of compound bee-glue, is made up of following material component: propolis 1-10 part, thioctic acid 1-10 part, L-I Uncle's sugar 10-30 part, Folium Mori 10-30 part, Fructus Momordicae charantiae 10-30 part, Rhizoma Dioscoreae 10-30 part, Radix Panacis Quinquefolii 10-30 part, Herba Dendrobii 10-30 part is yellow Essence 10-30 part, Fructus Lycii 10-30 part, Cortex Lycii 10-30 part, Fructus Corni 10-30 part, Rhizoma Polygonati Odorati 10-30 part.
Further, it is made up of following material component: propolis 3-7 part, thioctic acid 3-7 part, L-arabinose 15-25 part, Folium Mori 15-25 part, Fructus Momordicae charantiae 15-25 part, Rhizoma Dioscoreae 15-25 part, Radix Panacis Quinquefolii 15-25 part, Herba Dendrobii 15-25 part, Rhizoma Polygonati 15-25 part, Chinese holly Qi 15-25 part, Cortex Lycii 15-25 part, Fructus Corni 15-25 part, Rhizoma Polygonati Odorati 15-25 part.
Further, it is made up of following material component: propolis 5 parts, thioctic acid 5 parts, L-arabinose 20 parts, Folium Mori 20 Part, 20 parts of Fructus Momordicae charantiae, Rhizoma Dioscoreae 20 parts, Radix Panacis Quinquefolii 20 parts, Herba Dendrobii 20 parts, Rhizoma Polygonati 20 parts, Fructus Lycii 20 parts, Cortex Lycii 20 parts, Fructus Corni 20 parts, Rhizoma Polygonati Odorati 20 parts.
Further, described thioctic acid includes other chemistry such as L-thioctic acid, LA, alpha-lipoic acid, thioctamide The food stage of form or pharmaceutical grade thioctic acid.
A kind of formula of compound bee-glue, its manufacture method comprises the following steps:
Step 1: propolis, thioctic acid, L-arabinose are ground into powder.
Step 2: utilize water extraction to Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati is extracted.
Step 3: the powder crushed in step 1 is mixed with the extract of step 2 and makes pharmaceutical dosage form.
The invention has the beneficial effects as follows: the raw material of the present invention mostly is Chinese herbal medicine, wide material sources, low price；Scientific formulation Rationally, each component synergism, diabetes-alleviating and complication thereof are had preferably effect.
Detailed description of the invention
Embodiment 1:
The formula of a kind of compound bee-glue, is made up of following material component: propolis 2 parts, L-thioctic acid 2 parts, L-arabinose 8 Part, 5 parts of Folium Mori, 5 parts of Fructus Momordicae charantiae, Rhizoma Dioscoreae 8 parts, Radix Panacis Quinquefolii 8 parts, Herba Dendrobii 10 parts, Rhizoma Polygonati 5 parts, Fructus Lycii 8 parts, Cortex Lycii 10 parts, mountain Zhu Cornel 10 parts, Rhizoma Polygonati Odorati 6 parts.
A kind of formula of compound bee-glue, its preparation method is:
Step 1: propolis, L-thioctic acid, L-arabinose are ground into powder.
Step 2: utilize water extraction to Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati is extracted.
Step 3: the powder crushed in step 1 is mixed and made capsule, soft capsule, pill with the extract of step 2 With pharmaceutical dosage forms such as tablets.
Embodiment 2:
The formula of a kind of compound bee-glue, is made up of following material component: propolis 6 parts, thioctamide 5 parts, L-arabinose 25 parts, 20 parts of Folium Mori, 20 parts of Fructus Momordicae charantiae, Rhizoma Dioscoreae 20 parts, Radix Panacis Quinquefolii 25 parts, Herba Dendrobii 25 parts, Rhizoma Polygonati 20 parts, Fructus Lycii 30 parts, Cortex Lycii 30 parts, Fructus Corni 25 parts, Rhizoma Polygonati Odorati 20 parts.
A kind of formula of compound bee-glue, its preparation method is:
Step 1: propolis, thioctamide, L-arabinose are ground into powder.
Step 2: utilize water extraction to Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati is extracted.
Step 3: the powder crushed in step 1 is mixed and made capsule, soft capsule, pill with the extract of step 2 With pharmaceutical dosage forms such as tablets.
Embodiment 3:
The formula of a kind of compound bee-glue, is made up of following material component: propolis 5 parts, LA 5 parts, L-arabinose 20 parts, 20 parts of Folium Mori, 20 parts of Fructus Momordicae charantiae, Rhizoma Dioscoreae 20 parts, Radix Panacis Quinquefolii 20 parts, Herba Dendrobii 20 parts, Rhizoma Polygonati 20 parts, Fructus Lycii 20 parts, Cortex Lycii 20 parts, Fructus Corni 20 parts, Rhizoma Polygonati Odorati 20 parts.
A kind of formula of compound bee-glue, its preparation method is:
Step 1: propolis, LA, L-arabinose are ground into powder.
Step 2: utilize water extraction to Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati is extracted.
Step 3: the powder crushed in step 1 is mixed and made capsule, soft capsule, pill with the extract of step 2 With pharmaceutical dosage forms such as tablets.
Embodiment 4:
The formula of a kind of compound bee-glue, is made up of following material component: propolis 5 parts, alpha-lipoic acid 5 parts, L-arabinose 15 parts, 15 parts of Folium Mori, 15 parts of Fructus Momordicae charantiae, Rhizoma Dioscoreae 20 parts, Radix Panacis Quinquefolii 15 parts, Herba Dendrobii 15 parts, Rhizoma Polygonati 15 parts, Fructus Lycii 20 parts, Cortex Lycii 15 parts, Fructus Corni 15 parts, Rhizoma Polygonati Odorati 20 parts.
A kind of formula of compound bee-glue, its preparation method is:
Step 1: propolis, alpha-lipoic acid, L-arabinose are ground into powder.
Step 2: utilize water extraction to Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati is extracted.
Step 3: the powder crushed in step 1 is mixed and made capsule, soft capsule, pill with the extract of step 2 With pharmaceutical dosage forms such as tablets.
The ultimate principle of the present invention and principal character and advantages of the present invention, the technology of the industry have more than been shown and described Personnel, it should be appreciated that the present invention is not restricted to the described embodiments, simply illustrating this described in above-described embodiment and description The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these become Change and improvement both fall within scope of the claimed invention, the claimed scope of invention by appending claims and etc. Effect thing defines.

Claims (5)

1. the formula of a compound bee-glue, it is characterised in that be made up of following material component: propolis 1-10 part, thioctic acid 1-10 Part, L-arabinose 10-30 part, Folium Mori 10-30 part, Fructus Momordicae charantiae 10-30 part, Rhizoma Dioscoreae 10-30 part, Radix Panacis Quinquefolii 10-30 part, Herba Dendrobii 10-30 part, Rhizoma Polygonati 10-30 part, Fructus Lycii 10-30 part, Cortex Lycii 10-30 part, Fructus Corni 10-30 part, Rhizoma Polygonati Odorati 10-30 part.
The formula of a kind of compound bee-glue, it is characterised in that be made up of following material component: propolis 3-7 part, thioctic acid 3-7 part, L-arabinose 15-25 part, Folium Mori 15-25 part, Fructus Momordicae charantiae 15-25 part, Rhizoma Dioscoreae 15-25 part, the West Ginseng 15-25 part, Herba Dendrobii 15-25 part, Rhizoma Polygonati 15-25 part, Fructus Lycii 15-25 part, Cortex Lycii 15-25 part, Fructus Corni 15-25 part is beautiful Bamboo 15-25 part.
The formula of a kind of compound bee-glue, it is characterised in that be made up of following material component: propolis 5 Part, thioctic acid 5 parts, L-arabinose 20 parts, 20 parts of Folium Mori, 20 parts of Fructus Momordicae charantiae, Rhizoma Dioscoreae 20 parts, Radix Panacis Quinquefolii 20 parts, Herba Dendrobii 20 parts, yellow Essence 20 parts, Fructus Lycii 20 parts, Cortex Lycii 20 parts, Fructus Corni 20 parts, Rhizoma Polygonati Odorati 20 parts.
4. according to the formula of a kind of compound bee-glue described in any one in right 1-3, it is characterised in that described thioctic acid bag Include food stage or the pharmaceutical grade thioctic acid of other chemical specieses such as L-thioctic acid, LA, alpha-lipoic acid, thioctamide.
The formula of a kind of compound bee-glue the most according to claim 1, it is characterised in that its manufacture method includes following step Rapid:
Step 1: propolis, thioctic acid, L-arabinose are ground into powder.
Step 2: utilize water extraction to Folium Mori, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Herba Dendrobii, Rhizoma Polygonati, Fructus Lycii, Cortex Lycii, Fructus Corni, Rhizoma Polygonati Odorati Extract.
Step 3: the powder crushed in step 1 is mixed with the extract of step 2 and makes pharmaceutical dosage form.
CN201610692541.4A 2016-08-18 2016-08-18 The formula of a kind of compound bee-glue and preparation method Pending CN106237108A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1358515A (en) * 2000-12-20 2002-07-17 王国坤 Medicine for treating diabetes and process for preparing same
CN101040982A (en) * 2006-09-30 2007-09-26 浙江省中医药研究院 Chinese traditional compound for reducing blood suger
CN103652906A (en) * 2013-12-11 2014-03-26 罗永祺 Yin-nourishing fluid-generating dried rehamnnia root chewable tablet and preparation method
CN104001003A (en) * 2014-04-15 2014-08-27 吕士敏 Oral liquid and sublingual spraying agent for treating diabetes
CN104338010A (en) * 2013-07-30 2015-02-11 浙江大学 Traditional Chinese medicine composition for treatment of type 2 diabetes
CN104825797A (en) * 2015-05-04 2015-08-12 威海御膳坊生物科技有限公司 Propolis-bitter gourd composite preparation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1358515A (en) * 2000-12-20 2002-07-17 王国坤 Medicine for treating diabetes and process for preparing same
CN101040982A (en) * 2006-09-30 2007-09-26 浙江省中医药研究院 Chinese traditional compound for reducing blood suger
CN104338010A (en) * 2013-07-30 2015-02-11 浙江大学 Traditional Chinese medicine composition for treatment of type 2 diabetes
CN103652906A (en) * 2013-12-11 2014-03-26 罗永祺 Yin-nourishing fluid-generating dried rehamnnia root chewable tablet and preparation method
CN104001003A (en) * 2014-04-15 2014-08-27 吕士敏 Oral liquid and sublingual spraying agent for treating diabetes
CN104825797A (en) * 2015-05-04 2015-08-12 威海御膳坊生物科技有限公司 Propolis-bitter gourd composite preparation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
严余明等: "桑胶煎治疗2型糖尿病52例临床观察", 《中华中医药杂志》 *
彭铭泉: "糖尿病药膳", 《药膳食疗研究》 *
戴关海等: "山叶胶口服液对糖尿病模型小鼠血糖的影响", 《中国中医药科技》 *
陈大舜等: "2型糖尿病中医(中西医结合)证治研究", 《中医药学刊》 *

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