CN106668444A - Effervescent tablet for treating diabetes and preparation method thereof - Google Patents
Effervescent tablet for treating diabetes and preparation method thereof Download PDFInfo
- Publication number
- CN106668444A CN106668444A CN201510743106.5A CN201510743106A CN106668444A CN 106668444 A CN106668444 A CN 106668444A CN 201510743106 A CN201510743106 A CN 201510743106A CN 106668444 A CN106668444 A CN 106668444A
- Authority
- CN
- China
- Prior art keywords
- effervescent tablet
- crude drug
- preparation
- diabetes
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of an effervescent tablet for treating diabetes. The method comprises the steps of extracting effective components of raw medicine materials and preparing the effervescent tablet. A Yuye decoction is prepared from rhizoma dioscoreae, endothelium corneum gigeriae galli, radix astragali, radix puerariae, fructus schisandrae, radices trichosanthis and rhizoma anemarrhenae and is taken as a famous prescription recorded in Traditional Chinese Medicine Ancient Book and used for treating diabetes. The method is characterized by firstly extracting by using alcohol, then extracting by using sterile water, and carrying out rotary evaporation on an extraction solution to obtain extract. The problems of low content of effective components, a large quantity of impurities and high residual quantity of microorganisms of the conventional traditional Chinese medicine decoction are improved; the preparation adopts convenient and quick effervescent tablet; the requirements on long-term medication of patients with diabetes can be met; the effervescent tablet is relatively convenient to carry and take; compared with the conventional preparation, the defect of uncomfortable taste of the traditional Chinese medicine preparation is improved.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of effervescent tablet and its preparation for treating diabetes
Method.
Technical background：
Diabetes have become the 3rd in China's non-contagious chronic diseases principal disease (angiocardiopathy,
Tumour, diabetes), its disease time is long, is related to crowd extensively, has become the great health care of China
Problem.
Good wine soup is written by Qing Dynasty's name doctor's Zhang Xichun《Join west record in inner feelings》Described in, by Chinese yam, in chicken
Gold, the Radix Astragali, the root of kudzu vine, the fruit of Chinese magnoliavine, root of Chinese trichosanthes, wind-weed composition, for quenching one's thirst, i.e., pointed by Zhang Xichun
, the traditional Chinese medical science is quenched one's thirst the so-called diabetes of i.e. doctor trained in Western medicine.Current clinical medicine treats II phase diabetes using good wine soup,
Good wine soup can play a part of to treat diabetes by various paths and approach, it is existing it has been reported that mutually shutdown
System just has：1. there is adjustment effect to glycometabolism, suppresses or promote hepatic glycogenolytic, or promote hepatic glycogen to close
Into, promote glycolysis, increase utilization of the peripheral tissues to glucose.2. protection is played to insulin β cells
Insulin receptor number is 3. improved with the effect of the effect repaired, the protection of enhancing islet cells and reparation, is strengthened
Receptor binding, improves insulin resistance.4. the secretion of glucagon suppression, improves the activity of insulin.
Good wine soup is had to diabetes by preferable therapeutic action based on the studies above, can be developed and be taken for convenience
Assistant hypoglycemic product.
The existing formulation such as injection for Chinese medicine compound prescription, tablet has obvious defect.Chinese medicine compound prescription into
Divide complexity, injection medicine directly to enter blood, easily cause allergic reaction, safety coefficient is low, and develop injection
Cost intensive.Tcm development tablet is big due to crude drug amount, and effective component content is low, and single medication needs larger
The tablet of dosage can just make medicine absorption in blood reach effective blood concentration.It is known to freeze good wine soup
Dry powder extracts effective ingredient using water extraction, and active ingredient is prepared into into oral formulations (patent document 1), but
It uses water extraction effective component extracting higher for water-soluble preferable polysaccharide recovery rate, but to fat-soluble
Composition such as volatile oil, esters, extracting flavonoids rate is limited.
Therefore, it is contemplated that developing a kind of oral mouthfeel more preferably, active constituent content, high safety effectively drops
The medicine of sugar or assistant hypoglycemic.Safer compared to injection, low cost is more easy to be required long-term clothes
The diabetic of medicine is received.Compared to tablet, its effective component content is high, can without the need for a large amount of medications
Reach effective blood concentration.Than traditional traditional Chinese herbal decoction safety, health is convenient, and mouthfeel is more easy to by patient
Receive.
Patent document 1：CN102488827 A publications are opened in special admission to an organization or team
The content of the invention
It is an object of the invention to：Solve Chinese medicine compound prescription tradition decoction method active constituent content low, compound
Extract insufficient, liquid impurity is more, and content of microorganisms is exceeded, takes poor taste, carry, take not convenient
Problem, by the use of second alcohol and water as solvent, respectively effective component extracting, overcomes effective ingredient content
Low, compound extracts insufficient, and liquid impurity is more, the exceeded problem of content of microorganisms, and crude drug passes through immersion,
Distillation, the method for revolving makes main ingredient, then by adding auxiliary material, is made as particle, last whole grain, compressing tablet into
Type makes effervescent tablet, solves and takes poor taste, carries, and takes the problem of inconvenience, has reached medicine peace
Entirely, effectively, taking convenience efficiently purpose.
To achieve these goals, a kind of good wine soup effervescent tablet is prepared, is concretely comprised the following steps：
1) get the raw materials ready：The crude drug and auxiliary material prepared required for effervescent tablet is as follows, 2～15 parts of the Radix Astragali, and Chinese yam 4～
30 parts, 2～18 parts of the wind-weed, 0.6～5 part of the root of kudzu vine, 1～9 part of the fruit of Chinese magnoliavine, 1～9 part of root of Chinese trichosanthes, in chicken
Golden 0.8～6 part and citric acid, sodium carbonate (disintegrant) 3～15%, water (adhesive), dextrin, sugarcane
Sugared (diluent) 50～80%, orange flavor sucrose (flavouring) 0.5～3%, dodecyl sodium sulfate (profit
Lubrication prescription) 0.1～3%；
2) extracts active ingredients:
Alcohol extracting:Crude drug is weighed by above-mentioned ratio row, then add ethanol, ethanol solution and crude drug volume ratio be 1～
2:1 immersion crude drug 30min, then adds again ethanol solution, and the ratio to ethanol and crude drug amount is 4～6:1, return
Stream extracts 2h, after active ingredient is fully dissolved out, filtering liquid medicine, 10000～100000rpm at a high speed or
5～15min is centrifuged under Super High Speed Condition, the upper clear liquid medicine that centrifugation is obtained is reclaimed；
Water extraction：Crude drug after above-mentioned steps are filtered, then add sterilized water, sterilized water and the ratio of crude drug amount be 4～
6:1, refluxing extraction 2h, after being fully dissolved out etc. active ingredient, filtering liquid medicine is high in 10000～100000rpm
5～15min is centrifuged under speed or Super High Speed Condition, the upper clear liquid medicine that centrifugation is obtained is reclaimed；
Revolving：After the liquid mixing that above-mentioned two step is extracted, ethanol solution is evaporated using revolving instrument, is prepared
It is the medicinal extract containing high concentration active ingredient, it is standby；
3) effervescent tablet makes：The auxiliary material of medicine addition has disintegrant, adhesive, diluent, flavouring, profit
Lubrication prescription.Manufacturing process includes auxiliary material mixing, granulation, whole grain and compressing tablet；
1. pelletize：Disintegrant, diluent, flavouring are weighed, is mixed, as contained by effervescent tablet per piece effectively
Composition is calculated for 6 grams equivalent to primary dose, and medicinal extract is reconciled with bonding dilution agent, adds above-mentioned mixing
In auxiliary material, particle is made；
2. whole grain：Whole grain is carried out with 16 mesh and 20 mesh sieves, particle of uniform size is obtained, lubricant is added,
Measurement particle angle of repose, drug particles good fluidity as qualified less than 45 °；
3. compressing tablet：The qualified particle of mobility is added into tablet press machine, Shang Chong and lower stamping press is adjusted, weight is made
Difference, the qualified effervescent tablet of hardness and friability.
The beneficial effect of this programme is：
Using first alcohol extracting, then the method for water extraction, to crude drug in whole effective component extraction rate than simple use water as molten
Agent extraction efficiency is higher.Study and show Chinese yam, the membrane of a chicken's gizzard, the Radix Astragali, the root of kudzu vine, the fruit of Chinese magnoliavine, root of Chinese trichosanthes, in
Active ingredient mostly is saponin(e, flavones, volatile oil polysaccharide and ester type compound, and ethanol can extract polarity
The fat-soluble compounds such as less flavones, saponin(e, esters, volatile oil, then can extract polarity with water
The water soluble compounds such as larger polysaccharide, the method can fully extract active ingredient, it is to avoid because composition is carried
Take the waste for not exclusively causing.In addition, traditional Chinese medicine water decoction often content of microorganisms is exceeded, using ethanol
While extraction, crude drug in whole can be sterilized, remove microorganism.
Pharmaceutical dosage form is designed as effervescent tablet by present embodiment, because good wine soup shows to II phase treating diabetes effect
Write, and II phase diabetic generally requires lifelong medication, traditional Chinese medicine water decoction takes inconvenience, not portable
Band, mouthfeel is poor, and effervescent tablet improves these defects, more adapts to the rhythm of life for modernizing.
Specific embodiment
Embodiment one
1) get the raw materials ready：By 15 parts of the Radix Astragali, 30 parts of Chinese yam, 18 parts of the wind-weed, 5 parts of the root of kudzu vine, 9 parts of the fruit of Chinese magnoliavine,
9 parts of root of Chinese trichosanthes, the mass ratio that 6 parts of the membrane of a chicken's gizzard weighs following medicinal material：Radix Astragali 30g, Chinese yam 60g, wind-weed 36g,
Root of kudzu vine 10g, fruit of Chinese magnoliavine 18g, root of Chinese trichosanthes 18g, the membrane of a chicken's gizzard 12g, total crude drug amount is 184g.
2) extracts active ingredients
Alcohol extracting:Crude drug is weighed by above-mentioned ratio row, then add ethanol, ethanol solution is 1 with crude drug volume ratio:1
Immersion crude drug 30min, then adds again ethanol solution, and the ratio to ethanol and crude drug amount is 5:1, refluxing extraction
2h, after active ingredient is fully dissolved out, filtering liquid medicine, in 100000rpm ultracentrifugation 10min, is reclaimed
The upper clear liquid medicine that centrifugation is obtained.
Water extraction：Crude drug after above-mentioned steps are filtered, then add sterilized water, sterilized water is with the ratio of crude drug amount
5:1, refluxing extraction 2h, after being fully dissolved out etc. active ingredient, filtering liquid medicine, in 100000rpm ultrahigh speed bars
10min is centrifuged under part, the upper clear liquid medicine that centrifugation is obtained is reclaimed
Revolving：After the liquid mixing that above-mentioned two step is extracted, ethanol solution is evaporated using revolving instrument, is prepared
It is the medicinal extract containing high concentration active ingredient, it is standby.
3) effervescent tablet makes：
Total crude drug amount is 184g, is calculated by primary dose 6g per effervescent tablet, is 30 amounts, per effervesce
Piece is 4g, then bulk drug and auxiliary material total amount are 120g, and by following amounts auxiliary material is prepared：
1. pelletize：By citric acid, sodium carbonate, dextrin, sucrose, orange flavor, mixed, by effervescent tablet
Calculated equivalent to primary dose 6g per active ingredient contained by piece, medicinal extract is reconciled with suitable quantity of water dilution, plus
In entering above-mentioned mixed accessories, raw material " holding is agglomerating, and that what is touched dissipates " can be made into particle.
2. whole grain：Whole grain is carried out with 16 mesh and 20 mesh sieves, particle of uniform size is obtained, dodecyl is added
Sodium sulfonate 1.2g, measurement particle angle of repose is qualified, drug particles good fluidity less than 45 °.
3. compressing tablet：The qualified particle of mobility is added into tablet press machine, Shang Chong and lower stamping press is adjusted, weight is made
Difference, the qualified effervescent tablet of hardness and friability.
Embodiment two
1) get the raw materials ready：By 15 parts of the Radix Astragali, 30 parts of Chinese yam, 18 parts of the wind-weed, 5 parts of the root of kudzu vine, 9 parts of the fruit of Chinese magnoliavine,
9 parts of root of Chinese trichosanthes, the mass ratio that 6 parts of the membrane of a chicken's gizzard weighs following medicinal material：Radix Astragali 30g, Chinese yam 60g, wind-weed 36g,
Root of kudzu vine 10g, fruit of Chinese magnoliavine 18g, root of Chinese trichosanthes 18g, the membrane of a chicken's gizzard 12g, total crude drug amount is 184g.
2) extracts active ingredients
Alcohol extracting:Crude drug is weighed by above-mentioned ratio row, then add ethanol, ethanol solution is 1 with crude drug volume ratio:1
Immersion crude drug 30min, then adds again ethanol solution, and the ratio to ethanol and crude drug amount is 5:1, refluxing extraction
2h, after active ingredient is fully dissolved out, filtering liquid medicine, in 100000rpm ultracentrifugation 10min, is reclaimed
The upper clear liquid medicine that centrifugation is obtained.
Water extraction：Crude drug after above-mentioned steps are filtered, then add sterilized water, sterilized water is with the ratio of crude drug amount
5:1, refluxing extraction 2h, after being fully dissolved out etc. active ingredient, filtering liquid medicine, in 100000rpm ultrahigh speed bars
10min is centrifuged under part, the upper clear liquid medicine that centrifugation is obtained is reclaimed
Revolving：After the liquid mixing that above-mentioned two step is extracted, ethanol solution is evaporated using revolving instrument, is prepared
It is the medicinal extract containing high concentration active ingredient, it is standby.
3) effervescent tablet makes：
Total crude drug amount is 184g, is calculated by primary dose 6g per effervescent tablet, is 30 amounts, per effervesce
Piece is 4g, then bulk drug and auxiliary material total amount are 120g, and by following amounts auxiliary material is prepared：
1. pelletize：By citric acid, sodium carbonate, dextrin, sucrose, orange flavor, mixed, by effervescent tablet
Calculated equivalent to primary dose 6g per active ingredient contained by piece, medicinal extract is reconciled with suitable quantity of water dilution, plus
In entering above-mentioned mixed accessories, raw material " holding is agglomerating, and that what is touched dissipates " can be made into particle.
2. whole grain：Whole grain is carried out with 16 mesh and 20 mesh sieves, particle of uniform size is obtained, dodecyl is added
Sodium sulfonate 1.2g, measurement particle angle of repose is qualified, drug particles good fluidity less than 45 °.
3. compressing tablet：The qualified particle of mobility is added into tablet press machine, Shang Chong and lower stamping press is adjusted, weight is made
Difference, the qualified effervescent tablet of hardness and friability.
Embodiment three
1) get the raw materials ready：By 15 parts of the Radix Astragali, 30 parts of Chinese yam, 18 parts of the wind-weed, 5 parts of the root of kudzu vine, 9 parts of the fruit of Chinese magnoliavine,
9 parts of root of Chinese trichosanthes, the mass ratio that 6 parts of the membrane of a chicken's gizzard weighs following medicinal material：Radix Astragali 30g, Chinese yam 60g, wind-weed 36g,
Root of kudzu vine 10g, fruit of Chinese magnoliavine 18g, root of Chinese trichosanthes 18g, the membrane of a chicken's gizzard 12g, total crude drug amount is 184g.
2) extracts active ingredients
Alcohol extracting:Crude drug is weighed by above-mentioned ratio row, then add ethanol, ethanol solution is 1 with crude drug volume ratio:1
Immersion crude drug 30min, then adds again ethanol solution, and the ratio to ethanol and crude drug amount is 5:1, refluxing extraction
2h, after active ingredient is fully dissolved out, filtering liquid medicine, in 100000rpm ultracentrifugation 10min, is reclaimed
The upper clear liquid medicine that centrifugation is obtained.
Water extraction：Crude drug after above-mentioned steps are filtered, then add sterilized water, sterilized water is with the ratio of crude drug amount
5:1, refluxing extraction 2h, after being fully dissolved out etc. active ingredient, filtering liquid medicine, in 100000rpm ultrahigh speed bars
10min is centrifuged under part, the upper clear liquid medicine that centrifugation is obtained is reclaimed
Revolving：After the liquid mixing that above-mentioned two step is extracted, ethanol solution is evaporated using revolving instrument, is prepared
It is the medicinal extract containing high concentration active ingredient, it is standby.
3) effervescent tablet makes：
Total crude drug amount is 184g, is calculated by primary dose 6g per effervescent tablet, is 30 amounts, per effervesce
Piece is 4g, then bulk drug and auxiliary material total amount are 120g, and by following amounts auxiliary material is prepared：
1. pelletize：By citric acid, sodium carbonate, dextrin, sucrose, orange flavor, mixed, by effervescent tablet
Calculated equivalent to primary dose 6g per active ingredient contained by piece, medicinal extract is reconciled with suitable quantity of water dilution, plus
In entering above-mentioned mixed accessories, raw material " holding is agglomerating, and that what is touched dissipates " can be made into particle.
2. whole grain：Whole grain is carried out with 16 mesh and 20 mesh sieves, particle of uniform size is obtained, dodecyl is added
Sodium sulfonate 1.2g, measurement particle angle of repose is qualified, drug particles good fluidity less than 45 °.
3. compressing tablet：The qualified particle of mobility is added into tablet press machine, Shang Chong and lower stamping press is adjusted, weight is made
Difference, the qualified effervescent tablet of hardness and friability.
Claims (5)
1. it is a kind of to be used to treat diabetes effervescent tablet, it is characterised in that effervescent tablet composition is as follows：The Radix Astragali 2～
15 parts, 4～30 parts of Chinese yam, 2～18 parts of the wind-weed, 0.6～5 part of the root of kudzu vine, 1～9 part of the fruit of Chinese magnoliavine, smallpox
1～9 part of powder, 0.8～6 part of the membrane of a chicken's gizzard and citric acid, sodium carbonate (disintegrant) 3～15%, water is (viscous
Mixture), dextrin, sucrose (diluent) 50～80%, orange flavor sucrose (flavouring) 0.5～3%,
Dodecyl sodium sulfate (lubricant) 0.1～3%.
2. a kind of preparation method for treating diabetes effervescent tablet, it is characterised in that the effervescent tablet is by following
Prepared by method：
1) get the raw materials ready
Precision weighs the crude drug and auxiliary material required for effervescent tablet：2～15 parts of the Radix Astragali, 4～30 parts of Chinese yam, knows
It is female 2～18 parts, 0.6～5 part of the root of kudzu vine, 1～9 part of the fruit of Chinese magnoliavine, 1～9 part of root of Chinese trichosanthes, the membrane of a chicken's gizzard 0.8～6
Part and citric acid, sodium carbonate (disintegrant) 3～15%, water (adhesive), dextrin, sucrose (dilution
Agent) 50～80%, orange flavor sucrose (flavouring) 0.5～3%, dodecyl sodium sulfate (lubricant)
0.1～3%,；
2) extracts active ingredients
Alcohol extracting:Crude drug is weighed by above-mentioned ratio row, then add ethanol, ethanol solution and crude drug volume ratio be 1～
2:1 immersion crude drug 30min, then adds again ethanol solution, and the ratio to ethanol and crude drug amount is 4～6:1, return
Stream extracts 2h, after active ingredient is fully dissolved out, filtering liquid medicine, 10000～100000rpm at a high speed or
5～15min is centrifuged under Super High Speed Condition, the upper clear liquid medicine that centrifugation is obtained is reclaimed.
Water extraction：Crude drug after above-mentioned steps are filtered, then add sterilized water, sterilized water and the ratio of crude drug amount be 4～
6:1, refluxing extraction 2h, after being fully dissolved out etc. active ingredient, filtering liquid medicine is high in 10000～100000rpm
5～15min is centrifuged under speed or Super High Speed Condition, the upper clear liquid medicine that centrifugation is obtained is reclaimed
Revolving：After the liquid mixing that above-mentioned two step is extracted, ethanol solution is evaporated using revolving instrument, is prepared
It is the medicinal extract containing high concentration active ingredient, it is standby.
3) effervescent tablet makes：
1. pelletize：Disintegrant, diluent, flavouring are weighed, is mixed, as contained by effervescent tablet per piece effectively
Composition is calculated for 3～5 grams equivalent to primary dose, and medicinal extract is reconciled with bonding dilution agent, is added above-mentioned mixed
In closing auxiliary material, particle is made.
2. whole grain：Whole grain is carried out with 16 mesh and 20 mesh sieves, particle of uniform size is obtained, lubricant is added,
Measurement particle angle of repose, drug particles good fluidity as qualified less than 45 °.
3. compressing tablet：The qualified particle of mobility is added into tablet press machine, Shang Chong and lower stamping press is adjusted, weight is made
Difference, the qualified effervescent tablet of hardness and friability.
3. a kind of preparation method for treating the effervescent tablet of diabetes as claimed in claim 2, its feature
It is that described diluent is one or more in starch, sucrose, dextrin, lactose；Described disintegrant
For sodium carbonate, sodium acid carbonate, potassium carbonate, one or more in saleratus mix with citric acid；It is described
Lubricant be dodecyl sodium sulfate, magnesium stearate, talcum powder, one or more in hydrogenated vegetable oil；
Described adhesive be water, ethanol, one or more in starch slurry；Described flavouring agent is fruity flavor,
Peppermint oil, menthol, fructose, sucrose, one or more during Abbas is sweet.
4. a kind of preparation method for treating the effervescent tablet of diabetes as claimed in claim 2, its feature
It is that effective ingredient is extracted using first alcohol extracting, then the method for water extraction.
5. a kind of preparation method for treating the effervescent tablet of diabetes as claimed in claim 2, its feature
It is that crude drug passes through extraction, makes the medicinal extract containing high concentration active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510743106.5A CN106668444A (en) | 2015-11-05 | 2015-11-05 | Effervescent tablet for treating diabetes and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510743106.5A CN106668444A (en) | 2015-11-05 | 2015-11-05 | Effervescent tablet for treating diabetes and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106668444A true CN106668444A (en) | 2017-05-17 |
Family
ID=58857637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510743106.5A Pending CN106668444A (en) | 2015-11-05 | 2015-11-05 | Effervescent tablet for treating diabetes and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106668444A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107996937A (en) * | 2017-12-12 | 2018-05-08 | 苏州卫生职业技术学院 | Compound health-care effervescent tablet and its preparation process containing plant polyose |
-
2015
- 2015-11-05 CN CN201510743106.5A patent/CN106668444A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107996937A (en) * | 2017-12-12 | 2018-05-08 | 苏州卫生职业技术学院 | Compound health-care effervescent tablet and its preparation process containing plant polyose |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112972547A (en) | Traditional Chinese medicine composition for treating qi-blood deficiency syndrome and preparation method and application thereof | |
| US10894070B2 (en) | Drug compound for the control of blood glucose, blood lipids and weight | |
| US20110104290A1 (en) | Compositions for reducing blood glucose level and uses thereof | |
| CN102579836B (en) | Traditional Chinese medical dendrobium huoshanense composition and preparation method thereof | |
| CN105341893A (en) | Composition for assisting in reducing blood glucose and application | |
| CN105267755A (en) | Blood-glucose-reducing oral liquid | |
| CN106924374A (en) | A kind of composition and preparation method thereof and the application in hypoglycemic and/or reducing blood lipid product is prepared | |
| CN100518809C (en) | Medicinal composition for curing diabetes and nephropathy and its preparing method | |
| CN103316101B (en) | Traditional Chinese medicine for treating diabetic nephropathy and preparation method thereof | |
| CN1985921A (en) | Chinese medicine composition for treating common cold and its preparing method | |
| CN102579530A (en) | Preparation method of aralia taibaiensis total saponin having diabetes mellitus resisting effect and medicament | |
| CN106668444A (en) | Effervescent tablet for treating diabetes and preparation method thereof | |
| CN103977390A (en) | Method for preparing ginger-onion medicinal liquor composition and application thereof | |
| CN108524811A (en) | Reduce uric acid, cholesterol, three high Chinese medicine compositions and its preparation method for the treatment of | |
| CN1872232B (en) | Composition of medication for curing cerebrovascular disease, and preparation method | |
| CN104042928B (en) | A kind of pharmaceutical composition for treating diabetes and its production and use | |
| CN103393938B (en) | Traditional Chinese medicine composition for reducing blood sugar | |
| CN106109909A (en) | A kind of compositions for preventing and treating diabetes and hypertension | |
| CN105664102A (en) | Traditional Chinese medicine composition for improving immunity | |
| CN102715502B (en) | Preparation method of health food with function of anti-diabetes | |
| CN100453073C (en) | Compound radical lobelia dripping pill and its preparing method | |
| CN105327115A (en) | Phellinus linteus catharsis formula for prevention and cure of type II diabetes and preparation process thereof | |
| CN104547105A (en) | Agent for reducing blood glucose | |
| CN105535070B (en) | The pharmaceutical composition and its preparation method and application for treating diabetes | |
| CN104352748A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170517 |