CN101982193A - Traditional Chinese medicine composition for treating pulmonary tuberculosis, preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating pulmonary tuberculosis, preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating pulmonary tuberculosis, which comprises the following components of lilium brownie, ladybell root, lilyturf root, rehmannia, ginseng, cortex lycii, bulbus fritillariae cirrhosae, radix stemonae,common bletilla pseudobulb, radix astragali, Chinese yam and radix ranunculi ternati. The traditional Chinese medicine composition has the effect of nourishing yin for moistening lung, replenishing qi and invigorating the spleen, and can be used for preparing a medicine for preventing and treating pulmonary tuberculosis and/or lymph gland tuberculosis and/or tuberculous pleurisy. The invention also relates to a preparation method of the traditional Chinese medicine composition, which adopts different extraction methods according to the medicine properties of different herbal medicines to extract effective components in the herbal medicines maximally, thus enhancing medicine effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to phthisical Chinese medicine composition of a kind of treatment and its production and application, belong to technical field of Chinese medicines.
Background technology
Tuberculosis is the main killer in the infectious disease in the world today, according to World Health Organization's report, has every year 3000000 people to die from tuberculosis approximately.Tuberculosis belongs to motherland's medical science consumptive disease category, is to be invaded by consumptive disease worm (tulase) that human body is caused to have a communicable chronic expendable pathological changes, tosses about in bed the change of disease and causes the five internal organs and lose emptyly, has a delicate constitution.As everyone knows, pulmonary tuberculosis is one of fatal diseases.The lunger can be developed into slow fine hole, respiratory failure, pulmonary heart disease etc. at last as thoroughly not curing.Perhaps tulase causes other position secondary tuberculosis through lymph and hematogenous spread, binds nuclear etc. as bone tuberculosis, renal tuberculosis, digestion.Finally, make patient's disability, in addition viability, causing great misery and heavy financial burden to patient and family members, severe patient causes patient death.
On the other hand, pulmonary tuberculosis is a kind of infectious disease, and its source of infection is mainly the male lunger of expectorant smear.Sputum smear negative, to cultivate male patient's infectiousness less.According to statistics, an open lunger can be infected 20-30 healthy people every year, and China will have 2,000 ten thousand-4,000 ten thousand healthy people the whole year and infect tulase.
Chinese medicine is referred to as pulmonary tuberculosis to the pulmonary tuberculosis of modern medicine, thinks that its pathology is in the nature the deficiency of YIN, and at lung, with the passing of time son is taken mother-qi by force and involved in spleen at the beginning of the disease, forms the syndrome of lack of lung-YIN, deficiency-weakness of spleen-QI.
Clinically, pulmonary tuberculosis, tuberculous pleuritis and/or tuberculous lymphadenitis patient's main clinical manifestation has symptoms such as cough is breathed hard, dysphoria with feverish sensation in the chest palms and soles, dry mouth and throat, hectic fever, flushed cheeks, night sweat, spontaneous perspiration, spiritlessness and weakness, deficiency of QI with disinclination to talk, inappetence, sputum mixed with blood.
Treat pulmonary tuberculosis at present, tuberculous pleuritis, the medicine of diseases such as tuberculous lymphadenitis mainly contains Lei Mifeng, streptomycin, medicines such as rifampicin, though tuberculosis effect is preferably arranged, but the course of treatment is long, side effect is big, the formation of Resistant strain in addition, bring certain difficulty to treatment, and lack the medicine of strengthening the body resistance in the whole process, the consumption of disease itself is side effects of pharmaceutical drugs in addition, cause many patient's body constitution thin and weak, more therefore positive QI-insufficiency and make the touching difficulty of disease seeks safe and effective, can the treatment lungy and the effective medicine that keeps healthy be significant.
Summary of the invention
In order to solve the problems of the technologies described above, the inventor develops with nourishing YIN and moistening the lung, and replenishing QI to invigorate the spleen is the antituberculotics of main effect, at the deficiency of antituberculotics in the prior art, strengthens nutrition, and health invigorating reaches and has health care concurrently and treat purpose lungy.
The invention provides the phthisical Chinese medicine composition of a kind of treatment.
The present invention treats phthisical Chinese medicine composition and is made up of following bulk drugs: Bulbus Lilii 65-85 part, Radix Adenophorae 65-85 part, Radix Ophiopogonis 65-85 part, Radix Rehmanniae 65-85 part, Radix Ginseng 30-50 part, Cortex Lycii 45-65 part, Bulbus Fritillariae Cirrhosae 45-65 part, Radix Stemonae 45-65 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 45-65 part, Radix Astragali 45-65 part, Rhizoma Dioscoreae 45-65 part, Radix Ranunculi Ternati 45-65 part.
Wherein, the preferred Radix Rehmanniae of described Radix Rehmanniae, the preferred Radix Ginseng of described Radix Ginseng, the preferred Radix Astragali Preparata of the described Radix Astragali (frying to tack-free) according to processed with honey method (version pharmacopeia appendix IID in 2010).
Preferably, Chinese medicine composition of the present invention is made up of following bulk drugs: Bulbus Lilii 70-80 part, Radix Adenophorae 70-80 part, Radix Ophiopogonis 70-80 part, Radix Rehmanniae 70-80 part, Radix Ginseng 35-45 part, Cortex Lycii 50-60 part, Bulbus Fritillariae Cirrhosae 50-60 part, Radix Stemonae 50-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 50-60 part, Radix Astragali 50-60 part, Rhizoma Dioscoreae 50-60 part, Radix Ranunculi Ternati 50-60 part.
More preferably, Chinese medicine composition of the present invention is made up of following bulk drugs: 76 parts of Bulbus Liliies, 76 parts of Radix Adenophoraes, 76 parts of Radix Ophiopogonis, 76 parts of Radix Rehmanniae, 38 parts of Radix Ginsengs, 57 parts of Cortex Lycii, 57 parts of Bulbus Fritillariae Cirrhosaes, 57 parts of the Radixs Stemonae, 57 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 57 parts of the Radixs Astragali, 57 parts of Rhizoma Dioscoreaes, 57 parts of Radix Ranunculi Ternatis.
Chinese medicine is referred to as pulmonary tuberculosis to the pulmonary tuberculosis of modern medicine, thinks that its pathology is in the nature the deficiency of YIN, and at lung, with the passing of time son is taken mother-qi by force and involved in spleen at the beginning of the disease, forms the syndrome of lack of lung-YIN, deficiency-weakness of spleen-QI, so nourishing YIN and moistening the lung, replenishing QI to invigorate the spleen ought be the primary rule of treatment.Chinese medicine composition of the present invention is monarch with Bulbus Lilii, Radix Adenophorae nourishing YIN and moistening the lung, with Radix Ophiopogonis, Radix Rehmanniae, Bulbus Fritillariae Cirrhosae, Cortex Lycii replenishing YIN and removing heat, nourishing the lung to arrest cough is a minister, with Radix Ginseng, Radix Astragali Preparata, Rhizoma Dioscoreae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stemonae invigorating the spleen and benefiting QI, tonifying the lung,hemostasis and killing worm is assistant, Radix Ranunculi Ternati heat-clearing and toxic substances removing parasite killing is for making, and all medicines share plays nourishing YIN and moistening the lung, the effect of replenishing QI to invigorate the spleen altogether.
The present invention also provides the preparation method of described Chinese medicine composition.
The preparation method of Chinese medicine composition of the present invention comprises the steps:
1) with Radix Ginseng section, add water extraction 2-3 time that 8-12 doubly measures, each 1-3 hour, merge extractive liquid,, filtration obtains Radix Ginseng extractive solution and medicinal residues respectively;
2) Bulbus Fritillariae Cirrhosae is pulverized, added water extraction 2-3 time that 8-12 doubly measures, each 1-3 hour, merge extractive liquid,, filtration obtains Bulbus Fritillariae Cirrhosae extracting solution and medicinal residues respectively;
3) all the other ten flavor medical materials and above-mentioned medicine residues of Radix Ginseng and Bulbus Fritillariae Cirrhosae medicinal residues merge, and add water extraction 2-3 time that 8-12 doubly measures, 1-3 hour at every turn, merge extractive liquid, filters the filtrate of winning, described first filtrate and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution are merged, being concentrated into relative density is 1.11-1.16 (25 ℃), and precipitate with ethanol filters, continuing to be concentrated into relative density is 1.20-1.28 (25 ℃), water precipitating filters, and gets second filtrate; Add pharmaceutic adjuvant and make oral liquid in described second filtrate, perhaps that described second filtrate is concentrated, dry, pulverizing add pharmaceutic adjuvant and make tablet, capsule, granule or pill.
Wherein, the described extraction of step 1) is preferably extracted 2 times, and the water logging that adds 10 times of amounts was for the first time steeped 1 hour, extracted 2 hours, added the water of 8 times of amounts for the second time, extracted 2 hours.
Step 2) described extraction is preferably extracted 2 times, adds the water logging bubble 1.5 hours of 10 times of amounts for the first time, extracts 2 hours, and the water that add 8 times of amounts the second time extracted 2 hours.
The described extraction of step 3) is preferably extracted 3 times, adds the water of 10,8,8 times of amounts respectively, extracts successively 3,2,1 hours.
The described precipitate with ethanol of step 3) reaches 50-70% for adding ethanol to containing the alcohol amount, fully stirs, and leaves standstill 18-30 hour.
The described water precipitating of step 3) fully stirs for adding the water that concentrated medicament 2-4 doubly measures, and leaves standstill 45-55 hour.
The preparation method of the described oral liquid of step 3) is to add potassium sorbate 1-3 weight portion in described second filtrate, and Mel 250-300 weight portion stirs evenly, and places 18-30 hour, filters, and adds water and makes 1000 parts, stirs evenly packing, sterilization.
In the preparation method of the present invention, the property of medicine according to different flavour of a drug, at first Radix Ginseng section, Bulbus Fritillariae Cirrhosae are pulverized, respectively with water extraction, with its medicinal residues and all the other ten flavor medical material water extraction, extracting solution and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution merge, and adopt the mode of first precipitate with ethanol, back water precipitating then then, can maximize the effective ingredient that extracts each flavour of a drug, thereby improve drug effect.
Another object of the present invention provides the application of described Chinese medicine composition, preferably the application in the medicine of preparation prevention and treatment pulmonary tuberculosis and/or tuberculous lymphadenitis and/or tuberculous pleuritis.
The beneficial effect of Chinese medicine composition of the present invention is as follows:
1, each medicinal raw material is easy to get in the Chinese medicine composition of the present invention, and the side is monarch with Bulbus Lilii, Radix Adenophorae, nourishing YIN and moistening the lung master pulmonary tuberculosis chronic cough." book on Chinese herbal medicine meets former ": " Bulbus Lilii can be mended native clearing heat in the lung, cough-relieving diuresis "." Bencao Congxin ": " the special nourishing YIN of Radix Adenophorae (Radix Glehniae), the lung heat clearing fire is controlled the chronic cough consumptive lung disease "." decoction pieces is newly joined ": " Radix Adenophorae (Radix Glehniae) is supported the lung stomach-Yin, controls phthisical cough expectorant blood "; Be aided with Radix Ophiopogonis, the Radix Rehmanniae, Bulbus Fritillariae Cirrhosae, Cortex Lycii replenishing YIN and removing heat, nourishing the lung to arrest cough." book on Chinese herbal medicine converges and says ": " key medicine of Radix Ophiopogonis clearing away heart-fire and moistening the lung also." " book on Chinese herbal medicine converges and says ": " Bulbus Fritillariae Cirrhosae lung moistening eliminating stagnation, relieving cough and resolving phlegm is controlled cough due to consumptive disease, the spitting of blood of spitting blood." Radix Rehmanniae again can nourishing YIN and benefiting blood, controls fever due to yin deficiency.The Cortex Lycii clearing away heat and cooling blood is controlled asthenia hectic fever night sweat.Four ministerial drugs had both assisted monarch drug to strengthen the power of nourishing YIN and moistening the lung, again the heat of hectic fever due to YIN-deficiency clearly; Assistant is with Radix Ginseng, Radix Astragali Preparata, Rhizoma Dioscoreae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stemonae invigorating the spleen and benefiting QI, tonifying the lung,hemostasis and killing worm.Can building up the spleen to supplement the lung and lung benefiting can stop all medicines to hinder the fraud of stomach; Make with Radix Ranunculi Ternati heat-clearing and toxic substances removing parasite killing, all medicines share grow oiliness, mend then not dryly, play nourishing YIN and moistening the lung altogether, the effect of replenishing QI to invigorate the spleen.
2, the preparation method of Chinese medicine composition of the present invention can maximize the effective ingredient that extracts each flavour of a drug, thereby improves drug effect; Related equipment is simple, and cost is lower, can realize suitability for industrialized production.
3, by the medicine of Chinese medicine composition of the present invention preparation be applicable to that cough is breathed hard, dysphoria with feverish sensation in the chest palms and soles, hectic fever night sweat, dryness of the mouth and throat, spiritlessness and weakness, deficiency of QI with disinclination to talk, inappetence or the flushing in zygomatic region, cough with blood-flecked phlegm etc. with lack of lung-YIN, deficiency-weakness of spleen-QI are the treatment of diseases such as pulmonary tuberculosis, tuberculous pleuritis, tuberculous lymphadenitis of main clinical manifestation.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
[1] prescription:
Bulbus Lilii 76kg Radix Adenophorae 76kg 76kg Radix Ophiopogonis Radix Rehmanniae 76kg
Radix Ginseng 38kg Cortex Lycii 57kg Bulbus Fritillariae Cirrhosae 57kg Radix Stemonae 57kg
The Pseudobulbus Bletillae (Rhizoma Bletillae) 57kg Radix Astragali (processing) 57kg Radix Ranunculi Ternati 57kg Rhizoma Dioscoreae 57kg
[2] preparation method of oral liquid:
More than 12 flavors, the Radix Ginseng shave adds the water logging bubble 1 hour of 10 times of amounts, decocts 2 hours, adds the water of 8 times of amounts again, decocts collecting decoction, filtration 2 hours;
Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, and the water logging that adds 10 times of amounts was steeped 1.5 hours, decocted 2 hours, added the water of 8 times of amounts again, decocts 2 hours, and collecting decoction filters;
Ten flavors such as all the other Bulbus Liliies add 10 successively with above-mentioned medicine residues of Radix Ginseng and Bulbus Fritillariae Cirrhosae medicinal residues, 8,8 times of water gagings decoct 3 times, decoct 3 successively, 2,1 hour, collecting decoction, filter, filtrate and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution merge, and being concentrated into relative density is 1.11-1.16 (25 ℃), add ethanol and reach 60%, fully stir, left standstill 24 hours to containing the alcohol amount, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and continuing to be concentrated into relative density is 1.20-1.28 (25 ℃), and the water that adds 3 times of amount concentrated medicament volumes stirs evenly, left standstill 48 hours, filter, filtering residue washs with low amounts of water, and washing liquid is incorporated in the filtrate, add potassium sorbate 2kg, Mel 260kg (the water-bath thermosol is to clarification) stirs evenly, and places 24 hours, filter, add water and make 1000L, stir evenly, packing, sterilization, promptly.
Embodiment 2
[1] prescription:
Bulbus Lilii 65kg Radix Adenophorae 65kg 65kg Radix Ophiopogonis Radix Rehmanniae 65kg
Radix Ginseng 30kg Cortex Lycii 45kg Bulbus Fritillariae Cirrhosae 45kg Radix Stemonae 45kg
The Pseudobulbus Bletillae (Rhizoma Bletillae) 45kg Radix Astragali (processing) 45kg Radix Ranunculi Ternati 45kg Rhizoma Dioscoreae 45kg
[2] preparation method of tablet:
More than 12 flavors, the Radix Ginseng shave adds the water logging bubble 1.5 hours of 8 times of amounts, decocts 3 hours, adds the water of 8 times of amounts again, decocts collecting decoction, filtration 2 hours;
Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, and the water logging that adds 8 times of amounts was steeped 1 hour, decocted 3 hours, added the water of 8 times of amounts again, decocts 1 hour, and collecting decoction filters;
Ten flavors such as all the other Bulbus Liliies add 12 successively with above-mentioned medicine residues of Radix Ginseng and Bulbus Fritillariae Cirrhosae medicinal residues, 10,10 times of water gagings decoct 3 times, decoct 3 successively, 2,2 hours, collecting decoction, filter, filtrate and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution merge, and being concentrated into relative density is 1.11-1.16 (25 ℃), add ethanol and reach 50%, fully stir, left standstill 18 hours to containing the alcohol amount, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and continuing to be concentrated into relative density is 1.20-1.28 (25 ℃), the water that adds 2 times of amount concentrated medicament volumes stirs evenly, left standstill 45 hours, and filtered, filtering residue washs with low amounts of water, washing liquid is incorporated in the filtrate, concentrate, drying is ground into fine powder, add starch, dextrin, carboxymethyl starch sodium is an amount of, mixing is used 75% alcohol granulation, drying, it is an amount of to add magnesium stearate, mixing is granulated tabletting.
Embodiment 3
[1] prescription:
Bulbus Lilii 85kg Radix Adenophorae 85kg 85kg Radix Ophiopogonis Radix Rehmanniae 85kg
Radix Ginseng 50kg Cortex Lycii 65kg Bulbus Fritillariae Cirrhosae 65kg Radix Stemonae 65kg
The Pseudobulbus Bletillae (Rhizoma Bletillae) 65kg Radix Astragali (processing) 65kg Radix Ranunculi Ternati 65kg Rhizoma Dioscoreae 65kg
[2] preparation method of granule:
More than 12 flavors, the Radix Ginseng shave adds the water logging bubble 1 hour of 12 times of amounts, decocts 1.5 hours, adds the water of 10 times of amounts again, decocts collecting decoction, filtration 1.5 hours;
Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, and the water logging that adds 12 times of amounts was steeped 1 hour, decocted 1.5 hours, added the water of 10 times of amounts again, decocts 1.5 hours, and collecting decoction filters;
Ten flavors such as all the other Bulbus Liliies add 12 successively with above-mentioned medicine residues of Radix Ginseng and Bulbus Fritillariae Cirrhosae medicinal residues, 10,8 times of water gagings decoct 3 times, decoct 3 successively, 2,1 hour, collecting decoction filters, and filtrate and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution merge, being concentrated into relative density is 1.11-1.16 (25 ℃), add ethanol and reach 70%, fully stir, left standstill 30 hours to containing the alcohol amount, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and continuing to be concentrated into relative density is 1.20-1.28 (25 ℃), and the water that adds 4 times of amount concentrated medicament volumes stirs evenly, left standstill 55 hours, filter, filtering residue washs with low amounts of water, and washing liquid is incorporated in the filtrate, dry, be ground into fine powder, add ethanol and make binding agent, add starch and make filler, mixing is pressed into granule.
Embodiment 4
[1] prescription:
Bulbus Lilii 71kg Radix Adenophorae 71kg 71kg Radix Ophiopogonis Radix Rehmanniae 71kg
Radix Ginseng 34kg Cortex Lycii 52kg Bulbus Fritillariae Cirrhosae 52kg Radix Stemonae 52kg
The Pseudobulbus Bletillae (Rhizoma Bletillae) 52kg Radix Astragali (processing) 52kg Radix Ranunculi Ternati 52kg Rhizoma Dioscoreae 52kg
[2] preparation method of capsule:
More than 12 flavors, the Radix Ginseng shave adds the water logging bubble 1 hour of 9 times of amounts, decocts 2 hours, adds the water of 9 times of amounts again, decocts collecting decoction, filtration 2 hours;
Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, and the water logging that adds 9 times of amounts was steeped 1.5 hours, decocted 2 hours, added the water of 9 times of amounts again, decocts 2 hours, and collecting decoction filters;
Ten flavors such as all the other Bulbus Liliies add 10 successively with above-mentioned medicine residues of Radix Ginseng and Bulbus Fritillariae Cirrhosae medicinal residues, 8,8 times of water gagings decoct 3 times, decoct 2 successively, 2,2 hours, collecting decoction, filter, filtrate and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution merge, and being concentrated into relative density is 1.11-1.16 (25 ℃), add ethanol and reach 65% to containing the alcohol amount, fully stir, left standstill 24 hours, filter, filtrate recycling ethanol is to there not being the alcohol flavor, continuing to be concentrated into relative density is 1.20-1.28 (25 ℃), and the water that adds 3 times of amount concentrated medicament volumes stirs evenly, and leaves standstill 48 hours, filter, filtering residue washs with low amounts of water, and washing liquid is incorporated in the filtrate, concentrates, dry, pulverize, add adjuvants such as appropriate amount of starch, mixing, granulate, encapsulated.
Embodiment 5
[1] prescription:
Bulbus Lilii 81kg Radix Adenophorae 81kg 81kg Radix Ophiopogonis Radix Rehmanniae 81kg
Radix Ginseng 46kg Cortex Lycii 62kg Bulbus Fritillariae Cirrhosae 62kg Radix Stemonae 62kg
The Pseudobulbus Bletillae (Rhizoma Bletillae) 62kg Radix Astragali (processing) 62kg Radix Ranunculi Ternati 62kg Rhizoma Dioscoreae 62kg
[2] preparation method of pill:
More than 12 flavors, the Radix Ginseng shave adds the water logging bubble 1 hour of 12 times of amounts, decocts 1.5 hours, adds the water of 10 times of amounts again, decocts collecting decoction, filtration 1.5 hours;
Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, and the water logging that adds 12 times of amounts was steeped 1 hour, decocted 1.5 hours, added the water of 12 times of amounts again, decocts 1.5 hours, and collecting decoction filters;
Ten flavors such as all the other Bulbus Liliies add 10 successively with above-mentioned medicine residues of Radix Ginseng and Bulbus Fritillariae Cirrhosae medicinal residues, 8,8 times of water gagings decoct 3 times, decoct 3 successively, 2,1 hour, collecting decoction, filter, filtrate and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution merge, and being concentrated into relative density is 1.11-1.16 (25 ℃), add ethanol and reach 60% to containing the alcohol amount, fully stir, left standstill 24 hours, filter, filtrate recycling ethanol is to there not being the alcohol flavor, continuing to be concentrated into relative density is 1.20-1.28 (25 ℃), and the water that adds 3 times of amount concentrated medicament volumes stirs evenly, and leaves standstill 48 hours, filter, filtering residue washs with low amounts of water, and washing liquid is incorporated in the filtrate, concentrates, dry, pulverize, add an amount of refined honey pill, get pill.
Experimental example 1 pharmacological experiment
One, experiment material
1. animal: Kunming kind white mice, body weight 18-22g, male and female all can.
2. medicine: the oral liquid of the embodiment of the invention 1 preparation, brown liquid (patent medicine ml: crude drug g is 1: 1.07).With the solution of distilled water diluting to desired concn, gastric infusion, matched group give the distilled water of equal volume when using.Positive drug: ginseng royal jelly (prolonging limit medical college pharmaceutical factory); Orange productive cough liquid (the Chinese Guangdong China state pharmaceutical factory of traditional Chinese medicine); Cyclophosphamide (Shanghai No.12 Pharmaceutical Factory).
Two, experimental technique and result
1. to the influence of swimming time under the mice cryogenic conditions
Get 58 mices, be divided into five groups at random: blank group, ginseng royal jelly 20ml/kg dosed administration group, three dosed administration groups of oral liquid 5,2.5,1.25ml/kg of the embodiment of the invention 1 preparation.Once a day, successive administration is 5 days.After the last administration 1 hour, mice is placed 16 ± 1 ℃, swim in the water of dark 35cm, write down its time-to-live in water.
The result shows that oral liquid of the present invention can obviously increase the swimming time of mice under cryogenic conditions, can increase the resisting fatigue of mice and the ability of cold resistant.
2. to the influence of the anti-weary oxygen ability of mice
Get 59 mices, be divided into five groups at random: blank group, ginseng royal jelly 20ml/kg dosed administration group, three dosed administration groups of oral liquid 5,2.5,1.25ml/kg of the embodiment of the invention 1 preparation.Once a day, successive administration is 5 days.After the last administration 1 hour, mice is placed the 300ml conical flask that the 5g sodica calx is housed, jam-pack plug, the time-to-live of record mice under weary oxygen condition.
The result shows that oral liquid of the present invention can obviously prolong the time-to-live of mice under weary oxygen condition, can obviously increase the anti-weary oxygen ability of mice.
3. to the influence of mice reticuloendothelial system phagocytic function
Get 48 mices, be divided into five groups at random: blank group, ginseng royal jelly 20ml/kg dosed administration group, three dosed administration groups of oral liquid 5,2.5,1.25ml/kg of the embodiment of the invention 1 preparation.Once a day, successive administration is 5 days.After the last administration 1 hour,,, in mouse tail vein blood sampling 0.05ml/ only, place 5ml 1%Na respectively at 2 minutes thereafter and 15 minutes in the diluted prepared Chinese ink 10ml/kg of mouse tail vein injection
2CO
3In the solution,, calculate phagocytic index K, the results are shown in Table 1 in 650nm place colorimetric.
The influence of table 1 pair mice reticuloendothelial system phagocytic function
| Group | Mice (only) | K |
| The blank group | 11 | 0.0599±0.0256 |
| Ginseng royal jelly 20ml/kg | 10 | 0.0571±0.0179 |
| Oral liquid 5ml/kg of the present invention | 11 | 0.0721±0.0232 |
| Oral liquid 2.5ml/kg of the present invention | 8 | 0.0634±0.0194 |
| Oral liquid 1.25ml/kg of the present invention | 8 | 0.0547±0.0108 |
By table 1 result as seen, oral liquid of the present invention can make mice reticuloendothelial system phagocytic index that the trend of increase is arranged than matched group.
4. to the influence of hemolysin content in the mice serum
Get 60 mices, be divided into five groups at random: blank group, cyclophosphamide 20ml/kg intraperitoneal injection group, three dosed administration groups of oral liquid 5,2.5,1.25ml/kg of the embodiment of the invention 1 preparation.Once a day, successive administration is 10 days.Wherein only carry out immunity respectively at the 2nd, 5,8 day chicken erythrocyte suspension 0.2ml/ after the administration in mouse peritoneal injection 5%, after the last administration 1 hour with the animal sacrificed by decapitation, get blood, separation of serum, measure wherein hemolysin content, and win spleen, thymus is weighed, and the results are shown in Table 2.
The influence of hemolysin content and spleen and thymic weight in the table 2 pair mice serum
| Group | Mice (only) | OD | Thymus (mg/10g) | Spleen (mg/10g) |
| The blank group | 12 | 1.63±0.221 | 43.6±9.11 | 70.8±14.99 |
| Cyclophosphamide 20ml/kg | 12 | 0.06±0.055*** | 7.9±2.89*** | 30.1±8.60*** |
| Oral liquid 5ml/kg of the present invention | 12 | 1.77±0.081* | 42.4±13.26 | 79.8±15.01 |
| Oral liquid 2.5ml/kg of the present invention | 12 | 1.76±0.164 | 46.7±12.31 | 95.6±24.61** |
| Oral liquid 1.25ml/kg of the present invention | 12 | 1.81±0.102 | 48.8±8.68 | 81.2±17.12 |
By table 2 result as seen, oral liquid of the present invention can obviously increase hemolysin content in the mice serum, and spleen weight also significantly increases, and thymic weight also has the trend of increase.
5. to SO
2The influence of induced mice cough
Get 50 mices, be divided into five groups at random: blank group, orange expectoration liquid 30ml/kg dosed administration group, three dosed administration groups of oral liquid 5,2.5,1.25ml/kg of the embodiment of the invention 1 preparation.Once a day, successive administration is 5 days.After the last administration 1 hour, get a 25ml evaporating dish, the smart 0.5g anhydrous Na that claims of interior Sheng
2SO
3, with 5ml H
2SO
4(50%) inject evaporating dish rapidly, the glass beaker that is about to 500ml of existing side by side is buckled on the evaporating dish, and question response made the SO that is full of constant density in the beaker after 2 minutes
2, place and contain SO with being about to mice
2In the beaker, the cough number of times in incubation period and 1 minute that the observation mice takes place to cough the results are shown in Table 3.
Table 3 couple SO
2Cause the influence of mouse cough
| Group | Mice (only) | Incubation period (second) | Cough number of times (inferior) |
| The blank group | 10 | 20.3±11.53 | 22.1±16.47 |
| Orange expectoration liquid 30ml/kg | 10 | 32.8±19.8 | 9.2±5.31* |
| Oral liquid 5ml/kg of the present invention | 10 | 43.1±25.09* | 11.5±8.62 |
| Oral liquid 2.5ml/kg of the present invention | 10 | 23.1±15.43 | 15.6±9.50 |
| Oral liquid 1.25ml/kg of the present invention | 10 | 37.3±19.44* | 18.9±11.66 |
By table 3 result as seen, oral liquid of the present invention can obviously prolong SO
2Cause the incubation period of mouse cough, the mouse cough number of times also has the trend of minimizing.
6. the influence that phenol red method is eliminated the phlegm and tested
Get 41 mices, be divided into five groups at random: blank group, orange expectoration liquid 30ml/kg dosed administration group, three dosed administration groups of oral liquid 5,2.5,1.25ml/kg of the embodiment of the invention 1 preparation.Once a day, successive administration is 5 days.After the last administration 1 hour, as above method was carried out SO to mice
2Stimulate, and then administration 2 days, preceding 12 hours of last administration is with animal hunger, after the last administration 1 hour, inject 5% phenol red normal saline solution 10ml/kg in mouse peritoneal, after 30 minutes the animal dislocation is put to death, separate trachea, insert a 8* syringe needle in the Adam's apple place, fixing, slowly wash trachea 3 times with the 1ml normal saline then, take out the 0.6ml flushing liquor, add normal saline and be supplemented to 2ml, again to wherein adding 0.2ml 0.1N NaOH, with 546nm place colorimetric, the results are shown in Table 4.
The influence that the phenol red method of table 4 pair mice is eliminated the phlegm and tested
| Group | Mice (only) | Phenol red amount (ug/ml) |
| The blank group | 8 | 3.8±2.10 |
| Orange productive cough liquid 30ml/kg | 7 | 3.9±3.63 |
| Oral liquid 5ml/kg of the present invention | 9 | 6.1±2.35* |
| Oral liquid 2.5ml/kg of the present invention | 9 | 5.5±3.29 |
| Oral liquid 1.25ml/kg of the present invention | 8 | 5.7±3.48 |
By table 4 result as seen, oral liquid of the present invention can obviously increase mice phenol red output, has tangible phlegm-dispelling functions.
Above-mentioned experimental result shows, Chinese medicine composition of the present invention can obviously prolong the swimming time in the mice water at low temperature, strengthen the anti-weary oxygen ability of animal, promote the mice internal antibody to form, increase hemolysin content in the serum, the reticuloendothelial system phagocytic function also there are increase trend, enhancing body's immunological function; This medicine can prolong SO simultaneously
2Cause the incubation period of mouse cough, the cough number of times also has the trend of minimizing, and can increase animal phenol red output, has certain antitussive and phlegm-dispelling functions.Chinese medicine composition of the present invention is described in strong body, enhance immunity function, can benefits the recovery of this Chronic consumptions body of pulmonary tuberculosis.
Experimental example 2 clinical experiments
Be the definite curative effect of checking Chinese medicine composition of the present invention and the safety of clinical use, pulmonary tuberculosis, tuberculous pleuritis, the tuberculous lymphadenitis patient of lack of lung-YIN, deficiency-weakness of spleen-QI observed and verify, obtained comparatively satisfied curative effect.The clinical research result is as follows:
Physical data
200 routine patients suffer from pulmonary tuberculosis, tuberculous pleuritis and/or tuberculous lymphadenitis disease, and Chinese medical discrimination all belongs to lack of lung-YIN, deficiency-weakness of spleen-QI syndrome.Main clinical manifestation has that cough is breathed hard, dysphoria with feverish sensation in the chest palms and soles, dry mouth and throat, hectic fever, flushed cheeks, night sweat, spontaneous perspiration, spiritlessness and weakness, deficiency of QI with disinclination to talk, inappetence, sputum mixed with blood etc.
Treatment group (embodiment of the invention 1 preparation oral liquid): 124 routine patients, male's 59 examples wherein, women's 65 examples.30 years old person's 33 example of age less than, 31-40 year person's 35 examples, 41-50 year person's 19 examples, 51-60 year person's 25 examples, person's 12 examples more than 61 years old.The course of disease is not enough January person's 12 examples, 2-6 month person 17 examples, July-1 year person 22 examples, 2-5 person's 39 examples, person's 34 examples more than 6 years.
Matched group (anti-consumptive disease capsule): 76 examples, male's 33 examples wherein, women's 43 examples.Age, between year, the course of disease was between 1 month-6 years at 25-65.
The exclusion standard of MethodsThe cases enrolled
1. important organ serious diseases such as all merging are had the inclination, liver, kidney, the psychotic.
2. gestation or women breast-feeding their children.
3. the age is at under-18s, the over-65s person.
4. do not meet the standard of including in, not medication in accordance with regulations can't be judged curative effect, or data is not congruent affects the treatment and safety judgement person.
Test method
All MethodsThe cases enrolled are all filled in symptom, sign and other auxiliary examination project by the requirement of unified cooperation scheme.Wherein symptom is filled in by the scoring method of traditional Chinese medical science disease, put question to unified statement, allly initiatively said symptom note 4 minutes (+++), the symptom of getting, remarkable or lasting appearance the according to symptom, heavy or be interrupted and occur when light during symptom, mild symptoms or occur once in a while remembering 3 minutes (++), 2 minutes (+), 1 minute (±) respectively that asymptomatic is 0 minute (-).Any one note is 6 minutes in inspection and the pulse-taking.The auxiliary examination project is unified measurement unit by domestic current and is filled in.
Medication, the oral liquid for preparing with the embodiment of the invention 1 is a curative, each oral 20ml, every day three times, 4 weeks were 1 course of treatment.With anti-consumptive disease capsule is the contrast medicine, each oral 3, and every day three times, every dress 0.5g, 4 weeks were 1 course of treatment.Other strengthening by means of tonics medicine relevant of forbidding during the treatment with treatment; Finish the back comprehensive review course of treatment, and its result is adopted t check, rank test and X
2The method of inspection is carried out statistical procedures.
Result of the test
One, efficacy assessment standard
Produce effects: treatment back symptom integral value descends＞2/3 before the treatment;
Effectively: treatment back symptom integral value is the preceding decline 2/3-1/3 of treatment;
Invalid: treatment back symptom integral value descends＜1/3 before the treatment.
Two, efficacy analysis
(1) to the influence of grip and body weight
The administration of treatment group was measured patient's grip and body weight after 1 month, the results are shown in Table 5.
The influence of table 5 pair grip and body weight
| Project | n | Before the treatment | After the treatment | t | P |
| Grip (kg) | 94 | 29.8±6.9 | 31.2±7.2 | 8.39 | ＜0.01 |
| Body weight (kg) | 124 | 55.9±8.6 | 56.9±8.8 | 8.46 | ＜0.01 |
By the analysis of table 5 paired t-test as can be seen, adopt traditional Chinese medicine composition for treating of the present invention front and back to have significant differences (P＜0.01), illustrate that this product has the effect of certain enhancing human body grip and weight increase.
(2) to Immune Effects
The administration of treatment group was measured its influence to immunoglobulin after 1 month, the results are shown in Table 6.
The influence of table 6 pair immunoglobulin
| Project | n | Before the treatment | After the treatment | t | P |
| IgA(g/L) | 71 | 1.99±0.9 | 2.03±0.9 | 1.41 | ＞0.10 |
| IgG(g/L) | 71 | 11.5±2.9 | 11.8±2.96 | 1.87 | ＞0.05 |
| IgM(g/L) | 71 | 1.23±0.4 | 1.30±0.5 | 2.75 | ＜0.05 |
By the analysis of table 6 paired t-test as can be seen, Chinese medicine composition of the present invention has increases human immunoglobulin content IgM effect, with treat before compare and have significant differences (P＜0.05).In addition, this product has certain increase trend to IgA and IgG.
(3) to the influence of lack of lung-YIN, deficiency-weakness of spleen-QI symptom
The administration of treatment group was measured its influence to lack of lung-YIN, deficiency-weakness of spleen-QI symptom after 1 month, the results are shown in Table 7.
The influence of table 7 pair lack of lung-YIN, deficiency-weakness of spleen-QI symptom
Analyze as can be seen by table 7 rank test, own control P value is all less than 0.01 before and after the treatment, illustrate Chinese medicine composition of the present invention have clear improvement cough breathe hard, the effect of lack of lung-YIN such as dysphoria with feverish sensation in the chest palms and soles, dry mouth and throat, hectic fever night sweat, spiritlessness and weakness, deficiency of QI with disinclination to talk, deficiency-weakness of spleen-QI symptom.
(4) to body temperature, heart rate and leukocytic influence
The administration of treatment group was measured it to body temperature, heart rate and leukocytic influence after 1 month, the results are shown in Table 8.
Table 8 pair body temperature, heart rate and leukocytic influence
| Project | n | Before the treatment | After the treatment | t | P |
| Body temperature (℃) | 124 | 36.9±0.6 | 36.6±0.5 | 6.27 | ＜0.01 |
| Heart rate (inferior/minute) | 124 | 85.6±9.0 | 82.0±14.6 | 6.61 | ＜0.01 |
| WBC(×10 9/L) | 124 | 7.9±3.2 | 7.4±2.3 | 2.31 | ＜0.05 |
By the analysis of table 8 paired t-test as can be seen, Chinese medicine composition of the present invention has and reduces body temperature, heart rate and leukocytic effect, and there is significant difference (P＜0.05-0.01) in own control before and after the treatment.
(5) to the influence of body of the tongue, tongue fur and pulse condition
The administration of treatment group was measured its influence to picture of the tongue and pulse condition after 1 month, the results are shown in Table 9.
The influence of table 9 pair picture of the tongue and pulse condition
By table 9 as seen, this organizes 124 routine patients, and body of the tongue mostly is light or red before the treatment, and tongue fur mostly is few tongue, arteries and veins mostly be count accurately or heavy a little less than, reflected the essence of lack of lung-YIN, deficiency-weakness of spleen-QI.
Adopt X
2Statistical procedures is carried out in check, and relatively (P＜0.05-0.01) illustrates that this product makes pathology picture of the tongue, pulse condition better to the action effect of normal conversion before and after the treatment.
(6) chest X-ray
The chest X-ray improvement rate of treatment group is 36.4%, and the chest X-ray improvement rate of matched group is 27.6%.
(7) comprehensive therapeutic effect
124 routine patients in the treatment group took Chinese medicine composition of the present invention after 1 month, and produce effects 64 examples account for 51.6%, and effective 55 examples account for 44.4%, and invalid 5 examples account for 4%, and total effective rate is 96.0%.
76 routine patients in the matched group took the contrast medicine after 1 month, and produce effects 28 examples account for 36.8%, and effective 39 examples account for 51.4%, and invalid 9 examples account for 11.8%, and total effective rate is 88.2%.
Three, safety evaluatio
124 routine lack of lung-YIN, deficiency-weakness of spleen-QI patient observed result show, take this product and do not find obvious toxic-side effects after one month.Detect erythrocyte, hemoglobin, liver function, kidney merit, routine urinalysis before and after the treatment, its data all in normal range, illustrate that this product clinical practice is safe.
Model case
Example 1: the patient, Song, the man, 66 years old, cough was breathed hard, dysphoria with feverish sensation in the chest palms and soles is surplus January, companion's dry mouth and throat, spontaneous sweating, spiritlessness and weakness, deficiency of QI with disinclination to talk.Check symptom: red tongue, few tongue, thready pulse is number slightly, 37.5 ℃ of T, heart rate 90 times/minute; Blood pressure 16/11kpa; Chest X-rays: right upper lung patch shape shade is the visible transmission district wherein.Tcm diagnosis: pulmonary tuberculosis (lack of lung-YIN), doctor trained in Western medicine is examined: pulmonary tuberculosis.Take the oral liquid of the embodiment of the invention 1 preparation, each 20ml, every day three times, oral, after 4 weeks of taking medicine, patient's cough is breathed hard, all diseases of dysphoria with feverish sensation in the chest palms and soles obviously alleviate, muscle power strengthens, and grip increases, and check Chest X-rays right upper lung pathological changes has absorption, tongue fur, pulse condition transfer to normally, and clinical efficacy is judged as produce effects.
Example 2: Zou, the woman, 27 years old, before half a year, begin to occur cough, chest pain, obey the temporary transient improvement of antibiotics (medicine is not quite clear) certainly, increased the weight of in nearly two months.Check symptom: cough, chest pain, breathing are limited, spiritlessness and weakness, loss of appetite, and the red tongue tongue is white, thready and rapid pulse, and Chest X-rays is normal, and B ultrasonic is shown as pleuritis.Tcm diagnosis: hydrothorax, Western medicine diagnose: tuberculous pleuritis.Take the oral liquid of the embodiment of the invention 1 preparation, each 20ml took one month every day three times continuously, and all diseases disappear, and clinical efficacy is judged as produce effects.
Discuss and conclusion
Chinese medicine composition of the present invention is made up of 12 flavor Chinese medicines such as Bulbus Lilii, Radix Adenophorae, Radix Ophiopogonis, Radix Rehmanniae, Radix Ginseng, Cortex Lycii, Bulbus Fritillariae Cirrhosae, through water carry, series of processes such as precipitate with ethanol is refining forms, and being applicable to that cough is breathed hard, dysphoria with feverish sensation in the chest palms and soles, hectic fever night sweat, dryness of the mouth and throat, spiritlessness and weakness, deficiency of QI with disinclination to talk, inappetence or the flushing in zygomatic region, cough with blood-flecked phlegm etc. with lack of lung-YIN, deficiency-weakness of spleen-QI are the treatment of diseases such as pulmonary tuberculosis, tuberculous pleuritis, tuberculous lymphadenitis of main clinical manifestation.
124 routine lack of lung-YIN, deficiency-weakness of spleen-QI patient observed result shows, Chinese medicine composition of the present invention is breathed hard in the improvement cough, dysphoria with feverish sensation in the chest palms and soles, dry mouth and throat, hectic fever night sweat, flushed cheeks, spontaneous perspiration, spiritlessness and weakness, deficiency of QI with disinclination to talk, inappetence, in the time of symptoms such as sputum mixed with blood, certain physical strength reinforcing is arranged, increase grip, reduce body temperature, heart rate, improve the content of human immunoglobulin, improve the effect of chest x-ray sign, pathology picture of the tongue and pulse condition also there is certain improvement effect, total effective rate reaches 96.0%, and obvious effective rate reaches 51.6%, and does not have obvious toxic-side effects, be the good medicine of curative effect really, can be used in various treatments lungy or auxiliary treatment.
Adopt the Chinese medicine composition of embodiment 2-5 preparation to carry out above-mentioned experiment with method.The result shows: the phthisical Chinese medicine composition that is used for the treatment of of the present invention preparation has similar effect to the Chinese medicine composition of embodiment 1, wherein, is optimum with the effect of embodiment 1.Chinese medicine composition of the present invention truly has certain strong body, the function of enhance immunity, and the recovery of this Chronic consumptions body of pulmonary tuberculosis is benefited.
Claims (11)
1. treat phthisical Chinese medicine composition for one kind, it is characterized in that, form by following bulk drugs: Bulbus Lilii 65-85 part, Radix Adenophorae 65-85 part, Radix Ophiopogonis 65-85 part, Radix Rehmanniae 65-85 part, Radix Ginseng 30-50 part, Cortex Lycii 45-65 part, Bulbus Fritillariae Cirrhosae 45-65 part, Radix Stemonae 45-65 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 45-65 part, Radix Astragali 45-65 part, Rhizoma Dioscoreae 45-65 part, Radix Ranunculi Ternati 45-65 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, form by following bulk drugs: Bulbus Lilii 70-80 part, Radix Adenophorae 70-80 part, Radix Ophiopogonis 70-80 part, Radix Rehmanniae 70-80 part, Radix Ginseng 35-45 part, Cortex Lycii 50-60 part, Bulbus Fritillariae Cirrhosae 50-60 part, Radix Stemonae 50-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 50-60 part, Radix Astragali 50-60 part, Rhizoma Dioscoreae 50-60 part, Radix Ranunculi Ternati 50-60 part.
3. Chinese medicine composition according to claim 1, it is characterized in that, form: 76 parts of Bulbus Liliies, 76 parts of Radix Adenophoraes, 76 parts of Radix Ophiopogonis, 76 parts of Radix Rehmanniae, 38 parts of Radix Ginsengs, 57 parts of Cortex Lycii, 57 parts of Bulbus Fritillariae Cirrhosaes, 57 parts of the Radixs Stemonae, 57 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 57 parts of the Radixs Astragali, 57 parts of Rhizoma Dioscoreaes, 57 parts of Radix Ranunculi Ternatis by following bulk drugs.
4. the preparation method of each described Chinese medicine composition of claim 1-3 is characterized in that, comprises the steps:
1) with Radix Ginseng section, add water extraction 2-3 time that 8-12 doubly measures, each 1-3 hour, merge extractive liquid,, filtration obtains Radix Ginseng extractive solution and medicinal residues respectively;
2) Bulbus Fritillariae Cirrhosae is pulverized, added water extraction 2-3 time that 8-12 doubly measures, each 1-3 hour, merge extractive liquid,, filtration obtains Bulbus Fritillariae Cirrhosae extracting solution and medicinal residues respectively;
3) all the other ten flavor medical materials and above-mentioned medicine residues of Radix Ginseng and Bulbus Fritillariae Cirrhosae medicinal residues merge, and add water extraction 2-3 time that 8-12 doubly measures, 1-3 hour at every turn, merge extractive liquid, filters the filtrate of winning, described first filtrate and Radix Ginseng extractive solution and Bulbus Fritillariae Cirrhosae extracting solution are merged, concentrate, precipitate with ethanol filters, reconcentration, water precipitating filters, and gets second filtrate; Add pharmaceutic adjuvant and make oral liquid in described second filtrate, perhaps that described second filtrate is concentrated, dry, pulverizing add pharmaceutic adjuvant and make tablet, capsule, granule or pill.
5. preparation method according to claim 4 is characterized in that, step 1) is described to be extracted as 2 times, and the water logging that adds 10 times of amounts was for the first time steeped 1 hour, extracted 2 hours, added the water of 8 times of amounts for the second time, extracted 2 hours.
6. preparation method according to claim 4 is characterized in that step 2) described being extracted as 2 times, the water logging that adds 10 times of amounts was for the first time steeped 1.5 hours, extracted 2 hours, added the water of 8 times of amounts for the second time, extracted 2 hours.
7. preparation method according to claim 4 is characterized in that, step 3) is described to be extracted as 3 times, adds the water of 10,8,8 times of amounts respectively, extracts successively 3,2,1 hours.
8. preparation method according to claim 4 is characterized in that, the described precipitate with ethanol of step 3) reaches 50-70% for adding ethanol to containing the alcohol amount, fully stirs, and leaves standstill 18-30 hour.
9. preparation method according to claim 4 is characterized in that, the described water precipitating of step 3) fully stirs for adding the water that concentrated medicament 2-4 doubly measures, and leaves standstill 45-55 hour.
10. preparation method according to claim 4, it is characterized in that, the preparation method of the described oral liquid of step 3) is to add potassium sorbate 1-3 weight portion in described second filtrate, and Mel 250-300 weight portion stirs evenly, placed 18-30 hour, filter, add water and make 1000 parts, stir evenly, packing, sterilization.
11. the application of each described Chinese medicine composition of claim 1-3 in the medicine of preparation prevention and treatment pulmonary tuberculosis and/or tuberculous lymphadenitis and/or tuberculous pleuritis.
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| CN103316219A (en) * | 2013-07-01 | 2013-09-25 | 周汉升 | Traditional Chinese medicinal preparation for treating phthisis and preparation method thereof |
| CN103705738A (en) * | 2013-12-19 | 2014-04-09 | 太仓市伟基生物科技有限公司 | Phthisical traditional Chinese medicine capsule for treating refractory hemoptysis |
| CN103845667A (en) * | 2012-12-02 | 2014-06-11 | 邓小立 | Traditional Chinese medicine for treating drug-resistant tuberculosis |
| CN103933480A (en) * | 2014-04-28 | 2014-07-23 | 济南伟传信息技术有限公司 | Traditional Chinese medicament for treating phthisis |
| CN104771645A (en) * | 2014-01-17 | 2015-07-15 | 李庆方 | Application of traditional Chinese medicine composition paste for treatment of pulmonary tuberculosis |
| CN110496200A (en) * | 2019-09-23 | 2019-11-26 | 舒虹 | It is a kind of to treat phthisical Chinese medicine composition and its preparation method and application |
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