CN100594924C - Traditional Chinese medicine composition for lowering blood-lipid, and method for preparing the same - Google Patents
Traditional Chinese medicine composition for lowering blood-lipid, and method for preparing the same Download PDFInfo
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Abstract
The invention provides a pharmaceutical composition for treating hyperlipemia and its preparing process, wherein the medicinal composition comprises powder of rice fermented with red yeast, haw and oriental water plantain rhizome through extracting by ethanol backflow, concentrating the alcohol liquid to obtain concrete, vacuum drying, disintegrating and passing through 80 mesh sieve, and mixing the powdery raw materials.
Description
Invention field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly a kind of pharmaceutical composition that is used for the treatment of hyperlipemia (being hyperlipidemia) and preparation method thereof.
Background technology
Hyperlipemia is person in middle and old age's commonly encountered diseases, is one of risk factor that causes the atherosclerotic cardiovascular and cerebrovascular disease, and therefore, it is all significant for preventing and treating diseases such as coronary heart disease, hypertension, atherosclerosis, cerebrovascular accident to reduce too high blood fat.So on the basis of diet control, use medicine or health product to reduce blood middle cholesterol content, significant for treatment hyperlipemia and cerebrovascular.The traditional Chinese medical science uses the dialectical treatment hyperlipemia that combines with differential diagnosis of diseases to accumulate rich experience in secular clinical practice, studies confirm that Chinese medicine hyperlipemia determined curative effect has than remarkable advantages, is subjected to the generally attention of Chinese scholars day by day.Compare with doctor trained in Western medicine, Chinese traditional treatment has following characteristics: emphasize determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, pay attention to the integral body medical treatment advantage of compound recipe, it is obvious to improve clinical symptoms, toxic and side effects is little, and Chinese medicine has wide material sources, lower-price characteristic, therefore, fully excavate the rich experiences of Chinese medicine hyperlipemia, in conjunction with research and the Chinese medicine latest developments of modern medicine to primary disease, develop a kind of determined curative effect, cheap, be fit to China's national situation, carry taking convenience, the Chinese patent medicine of the treatment hyperlipemia that has no side effect has important theoretical meaning and value for clinical application, for numerous patients and family bring glad tidings.
Summary of the invention
One object of the present invention is to disclose a kind of pharmaceutical composition; Another object of the present invention is to disclose a kind of pharmaceutical composition that is used for the treatment of hyperlipemia (being hyperlipidemia); The 3rd purpose of the present invention is to disclose a kind of preparation of drug combination method.
The crude drug of pharmaceutical composition of the present invention is formed and proportioning following (by weight):
Hongqu powder (red colouring agent) 100-500 weight portion Fructus Crataegi 200-800 weight portion
Rhizoma Alismatis 100-400 weight portion
It is (by weight) that the crude drug of pharmaceutical composition of the present invention is formed optimum ratio:
Hongqu powder (red colouring agent) 250 weight portion Fructus Crataegis 550 weight portions
Rhizoma Alismatis 350 weight portions
It is (by weight) that the crude drug of pharmaceutical composition of the present invention is formed optimum ratio:
Hongqu powder (red colouring agent) 200 weight portion Fructus Crataegis 700 weight portions
Rhizoma Alismatis 300 weight portions
It is (by weight) that the crude drug of pharmaceutical composition of the present invention is formed optimum ratio:
Hongqu powder (red colouring agent) 150 weight portion Fructus Crataegis 750 weight portions
Rhizoma Alismatis 200 weight portions
This preparation of drug combination method:
Fructus Crataegi, Rhizoma Alismatis are broken into coarse grain; Fructus Crataegi is used 60-90% alcohol reflux 2-3 time, doubly measure alcohol reflux with 6-12 at every turn, each 1-3 hour, merge alcohol extract, filter, concentrating under reduced pressure, temperature 50-85 ℃, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder A gets dry extract; The Rhizoma Alismatis of alcohol extraction medicinal residues and formula ratio is mixed, with water boiling and extraction 2-3 time, with 5-10 times of water gaging reflux, extract, 1-3 hour, merge the water extract at every turn, filter, concentrating under reduced pressure, temperature 50-85 ℃, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder B gets dry extract; The aseptic Hongqu powder (red colouring agent) of dried cream powder A, dried cream powder B and formula ratio is mixed, with Multidimensionblender fully mix this pharmaceutical composition, this pharmaceutical composition can be made into clinical acceptable forms, comprises tablet, granule, capsule, soft capsule, oral liquid, drop pill, pill, powder etc.
Pharmaceutical composition of the present invention has remarkable result to blood fat reducing.
Pharmacodynamics to this medicament composition capsule preparation (the new purport recovering capsule of inferior precious board) partly carries out preliminary study, experiment shows that the new purport recovering capsule of inferior precious board can significantly reduce rat blood serum T-CHOL and triglyceride levels (P＜0.05), points out this medicine to have auxiliary lipid-lowering function; The human trial report shows: test group self paired comparison, before test back CHOL, TG and the test decline is arranged more all, learn by statistics and handle, difference has significance meaning (P＜0.05 or P＜0.01), test back test group CHOL, TG and matched group more also have decline, learn by statistics and handle, difference has significance meaning (P＜0.05 or P＜0.01), represents that this medicine has hypolipemic function.Following experimental example is used to further specify the present invention:
The new purport recovering capsule of experimental example 1 inferior precious board hypolipemic function zoopery report
1 material and method
1.1 sample: capsule, brownish red powder, 0.3g/ grain are provided by Shanxi Yabao Pharmaceutical Co., Ltd..Putting shady and cool dry place preserves.The oral recommended dose of human body is every day 3 times, and each 2, the adult press the calculating of 60kg body weight, amounts to dosage 0.03g/kgbw,
1.2 laboratory animal and environmental condition: 40 of the cleaning level male SD rats that animal technical college laboratory animal plant of Agricultural University Of Hunan provides, body weight 156.99 ± 10.43g.The laboratory animal production licence number is SCXK (Hunan) 2003-0003 number.The experimental session ambient temperature is 21 ℃-24 ℃, humidity 56%-58%.The laboratory animal occupancy permit number is SYXK (Hunan) 2003-0002 number.
1.3 dosage is selected: establish basic, normal, high dosage and be respectively 0.15g/kgbw, 0.30g/kgbw, 0.90g/kgbw (be equivalent to respectively human body recommended amounts 5,10,30 times), be subjected to that the test solution preparation time is got the new purport recovering capsule of inferior precious board 1.5g, 3.0g respectively, the 9.0g adding distil water is assigned to 100ml, matched group gives the equal-volume distilled water, give animal subject respectively and irritate stomach, once a day, irritate the long-pending 1.0ml/100g.bw of being of body of stomach, continuous 30 days.
1.4 key instrument, equipment and reagent: the OLYMPUSAU400 automatic clinical chemistry analyzer, LD5-10B centrifuge etc.:, cholesterol (CHOL), triglyceride (TG) be available from Shanghai Foxing Changzheng medical science Co., Ltd: HDL-C (HDL-C) test kit is available from health Bioisystech Co., Ltd of Erie.
1.5 high lipid food: 78.8% normal feedstuff, 1% cholesterol, 10% yolk powder, 10% Adeps Sus domestica, 0.2% cholate.
1.6 experimental technique: after observing a week with normal feedstuff feed rat, fasting 16 hours, get Sanguis sus domestica, measure serum total cholesterol (TC), triglyceride (TG), HDL-C (HDL-C) with the OLYMPUSAU400 automatic clinical chemistry analyzer, take into account TG according to the TC level animal is divided into 4 groups at random: high fat matched group and three are tried the thing group.Begin from formal test, each treated animal is used high lipid food instead, is tried the thing group simultaneously and irritates the test solution that is subjected to that stomach gives variable concentrations by above-mentioned dosage design, and high fat matched group filling stomach gives the distilled water with volume, continuous 30 days, weighs once weekly.Finish fasting 16 hours in experiment, pull out the eyeball blood sampling and measure serum TC, TG, HDL-C.
1.7 the date processing data are carried out statistical analysis with Spss software.Earlier data are carried out homogeneity test of variance, if variance is neat, adopt one factor analysis of variance totally to compare, the reuse Dunnett method that finds differences is carried out comparing in twos between a plurality of dosage groups and matched group mean.If heterogeneity of variance, then initial data is carried out suitable friendship amount conversion, after satisfying homogeneity of variance and testing, add up with the data after changing; If do not reach the neat purpose of variance yet after the variable conversion, to use rank test instead and add up, discovery is overall more variant, then adopts Tamhane ' the sT2 check that does not require homogeneity of variance to compare in twos.
1.8 the result judges: the hypolipemic function result judges: in serum total cholesterol, triglyceride, HDL-C detect, serum total cholesterol, the triglyceride two top index positives, this given the test agent hypolipemic function zoopery of decidable is the positive as a result.
The triglyceride reducing result judges: 1. two dosage groups of triglyceride positive as a result; 2. dosage group of triglyceride positive as a result, HDL-C is significantly higher than matched group simultaneously, the auxiliary sweet great three ester zooperies positive as a result that reduces of this given the test agent of decidable.
Reducing the serum total cholesterol result judges: 1. two dosage groups of serum total cholesterol positive as a result; 2. dosage group of serum total cholesterol positive as a result, HDL-C is significantly higher than matched group simultaneously, the auxiliary serum total cholesterol zoopery positive as a result that reduces of this given the test agent of decidable.
The influence of the 2 pairs of Serum TC, TG
See Table 1.After the experiment, high fat matched group serum TC, TO all obviously raise, and relatively preceding with experiment, difference has significance (P＜0.05), show the modeling success.The new purport recovering capsule of inferior precious board with 0.15g/kg ' bw, 0.30g/kg ' bw, 0.90g/kg ' bw dosage is given rat oral gavage 30 days, compare with high fat matched group, 0.30g/kg ' bw, 0.90g/kg ' bw dosage can significantly reduce raises total sterin of high lipid food rat blood serum and triglyceride levels P＜0.05).
Respectively organize the serum TC level before and after table 1 experiment
Respectively organize the serum TG level before and after table 2 experiment
Brief summary: the new purport recovering capsule of inferior precious board with 0.15g/kg ' bw, 0.30g/kg ' bw, 0.90g/kg ' bw dosage is given rat oral gavage 30 days, compare with high fat matched group, 0.30g/kg ' bw, 0.90g/kg ' bw dosage can significantly reduce and raise high lipid food rat blood serum T-CHOL and triglyceride levels (P＜0.05), the prompting submitted sample has hypolipemic function.
The new purport recovering capsule of experimental example 2 inferior precious boards hypolipemic function effect on human body test laboratory report
1 material and method
1.1 the new purport recovering capsule of the inferior precious board of sample provides by Shanxi Yabao Pharmaceutical Co., Ltd. for No. 1, No. 2, is capsule formulation, the 0.3g/ grain, and both outward appearances, taste are basic identical, and one of them is the new purport recovering capsule of inferior precious board, and another is a placebo.The oral recommended dose of human body is every day 3 times, each 2.
1.2 the experimenter selects
1.2.1 the standard of including in: the experimenter is selected from Yuelu District, Changsha City, Hunan Province community, male or female.Age 18-65 year, the crowd of simple dyslipidemia, twice blood sampling in half a year, twice serum total cholesterol is 〉=5.2mmol/L or serum glycerol three cruel 〉=1.65mmol/L, all can be used as alternative objects, and aspiration is subjected to examination to guarantee to cooperate.
1.2.2 experimenter's exclusion standard: gestation or women breast-feeding their children, to this product allergy sufferers; Be associated with serious disease patients such as the heart, liver, kidney and hemopoietic system; Take the article relevant in a short time, have influence on judgement person as a result with being tried function: do not meet the standard of including in, edible in accordance with regulations given the test agent, can't judge effect or data not umbra ring effect or safety judgement person.
1.3 experimental design and grouping
Adopt two kinds of control design between self and group.Be divided into inferior precious board new purport recovering capsule test group and placebo group at random by experimenter's blood lipid level, consider to influence result's principal element such as age, sex etc. as far as possible, carry out the harmony check, with the comparability between the assurance group.Test by double-blind method.
1.4 test method
The experimenter is on the October 10th, 2004 of blood sampling survey for the first time blood fat, the dyslipidemia person is in 2005 02 month 22 orders survey blood fat of taking a blood sample for the second time, twice all unusual person includes test in, test in beginning on 02 23rd, 2005, the experimenter takes the sample 3 times that Shanxi Yabao Pharmaceutical Co., Ltd. provides every day, each 2, took continuously 45 days.Duration of test does not change original dietary habit, normal diet.
2 observation index: each measures once every observation index when test on-test and end.
2.1 safety indexes
2.1.1 general physical examination: perquisition and understand experimenter's situations such as spirit, sleep, diet, defecation, blood pressure before the test.2.1.2 routine blood test: red blood cell count(RBC), numeration of leukocyte and classification, content of hemoglobin mensuration etc.2.1.3 routine urinalysis: pH value, leukocyte, glucose in urine etc.2.1.4 stool for routine.2.1.5 Abdominal B type ultrasonography, electrocardiogram, the fluoroscopy of chest of X line are checked.2.1.6 liver function test: total serum protein (TP), albumin (ALB), glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) are measured.2.1.7 kidney function test: serum urea nitrogen (BUN), creatinine (Cr), blood glucose (GLU) are measured.
2.2 effect index: cholesterol (CHOL), triglyceride (TG), HDL-C (HDL-C)
3 results judge
3.1CHOL reduce＞10%; TG reduction＞15%:HDL-C rising＞0.104mmol/L: self relatively and between the group of test back more all has statistical significance before and after each effect observation index test, can judge this index positive;
3.2 serum cholesterol, the triglyceride binomial index positive, HDL-C significantly is not lower than matched group, and the decidable given the test agent has the auxiliary lipid-lowering function effect; Positive in serum cholesterol, the triglyceride binomial index, HDL-C significantly is not lower than matched group, and the decidable given the test agent has the serum cholesterol of reduction or auxiliary triglyceride reducing effect.
4 statistical procedures
Data result represents with mean ± standard deviation, self paired data adopts paired t-test, between test group and the matched group under the prerequisite of homogeneity of variance, mean relatively adopts t check in groups, otherwise adopt the t check after carrying out satisfying homogeneity of variance after variable transforms, if variance is still uneven, adopt rank test.
5 results: double-blind method is observed and finished to make known: clothes contain No. 2 persons and are the new purport recovering capsule of inferior precious board, take No. 1 person and are placebo.
5.1 effect is observed
Before and after the test change of serum C HOL, the horizontal situation of change of TG, HDL-C see Table 3, table 4 and table 5; Before the test, matched group and test group change of serum C HOL, TG, HDL-C level compare, and not statistically significant points out between two groups to have comparability.After the test, self relatively compares before test group test back CHOL, TG and the test, and difference has significance meaning (P＜0.05 or P＞0.01), and comparing difference does not have significance (P＞0.05) before matched group test back CHOL, TG and the test; Test back test group CHOL, TG and matched group compare, and difference has significance meaning (P＜0.05 or P＞0.01) prompting given the test agent to have the hypolipemic function effect.
Change of serum C HOL, TG, the horizontal situation of HDL-C before table 3 test
Change of serum C HOL, the horizontal situation of change of TG, HDL-C before and after table 4 test
Annotate: compare relatively P＜0.05 of P＜0.05 # and matched group before * and the test
* and preceding relatively P＜0.01 ## of test and matched group compare P＜0.01
Before and after table 5 test change of serum C HOL TG the HDL-C rate of change
6 results: adopt counter point between own control and group, the trial volunteer that selection meets experimental condition is taken and is tried thing after 45 days, the result shows: take the new purport recovering capsule test group self of inferior precious board paired comparison, compare before test group test back CHOL, TG and the test, difference has significance meaning (P＜0.05 or P＞0.01) test back test group CHOL, TG and matched group relatively, and difference has significance meaning (P＜0.05 or P＞0.01).The prompting given the test agent has the hypolipemic function effect.
Embodiment 1:
Hongqu powder (red colouring agent) 250kg Fructus Crataegi 550kg
Rhizoma Alismatis 350kg
Make tablet according to conventional method.
Embodiment 2:
Hongqu powder (red colouring agent) 200kg Fructus Crataegi 700kg
Rhizoma Alismatis 300kg
Make capsule according to conventional method.
Embodiment 3:
Hongqu powder (red colouring agent) 150kg Fructus Crataegi 750kg
Rhizoma Alismatis 200kg
Make granule according to conventional method.。
Embodiment 4
Hongqu powder (red colouring agent) 250kg Fructus Crataegi 550kg
Rhizoma Alismatis 350kg
Fructus Crataegi, Rhizoma Alismatis are broken into coarse grain; Fructus Crataegi is with 75% alcohol reflux 3 times, with 8 times of amount alcohol reflux, each 1.5 hours, merge alcohol extract at every turn, filter, concentrating under reduced pressure, 50 ℃ of temperature, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder A gets dry extract; The Rhizoma Alismatis of alcohol extraction medicinal residues and formula ratio is mixed, with water boiling and extraction 3 times, use 6 times of water gaging reflux, extract, 2 hours at every turn, merge the water extract, filter, concentrate, 50 ℃ of temperature, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder B gets dry extract; The aseptic Hongqu powder (red colouring agent) of dried cream powder A, dried cream powder B and formula ratio is mixed, with Multidimensionblender fully mix this pharmaceutical composition, make tablet.
Embodiment 5
Hongqu powder (red colouring agent) 200kg Fructus Crataegi 700kg
Rhizoma Alismatis 300kg
Fructus Crataegi, Rhizoma Alismatis are broken into coarse grain; Fructus Crataegi with 10 times of amount alcohol reflux, is measured alcohol reflux with 8 times for the first time for the second time with 80% alcohol reflux 2 times, each 2 hours, merge alcohol extract, filter concentrating under reduced pressure, 50 ℃ of temperature, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, is dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder A gets dry extract; The Rhizoma Alismatis of alcohol extraction medicinal residues and formula ratio is mixed, with water boiling and extraction 2 times, for the first time with 8 times of water gaging reflux, extract, 2 hours, for the second time with 6 times of water gaging reflux, extract, 1.5 hours, merge the water extract, filter, concentrate, 50 ℃ of temperature, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, is dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder B gets dry extract; The aseptic Hongqu powder (red colouring agent) of dried cream powder A, dried cream powder B and formula ratio is mixed, and the mixed powder after the inspection of semifinished product is qualified is filled with " 1 " capsule with the automatic filling machine filled capsules of capsule.With the at a high speed full-automatic hard capsule counting of the ZP-II type bottling machine branch bottle of packing into.Finished product is: 0.3g/ grain, 90/bottle.
Embodiment 6
Hongqu powder (red colouring agent) 150kg Fructus Crataegi 750kg
Rhizoma Alismatis 200kg
Fructus Crataegi, Rhizoma Alismatis are broken into coarse grain; Fructus Crataegi is with 85% alcohol reflux 2 times, with 10 times of amount alcohol reflux, each 2 hours, merge alcohol extract at every turn, filter, concentrate, 50 ℃ of temperature, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder A gets dry extract; The Rhizoma Alismatis of alcohol extraction medicinal residues and formula ratio is mixed, with water boiling and extraction 2 times, use 8 times of water gaging reflux, extract, 2 hours at every turn, merge the water extract, filter, concentrate, 50 ℃ of temperature, being concentrated into relative density is the extractum of 1.20-1.25 (50 ℃ of mensuration), with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder B gets dry extract; The aseptic Hongqu powder (red colouring agent) of dried cream powder A, dried cream powder B and formula ratio is mixed, fully be mixed and made into granule with Multidimensionblender.
Claims (9)
1, a kind of pharmaceutical composition for the treatment of hyperlipemia is characterized in that this pharmaceutical composition made by following raw material medicaments:
Hongqu powder (red colouring agent) 250 weight portion Fructus Crataegis 550 weight portions
Rhizoma Alismatis 350 weight portions.
2, a kind of pharmaceutical composition for the treatment of hyperlipemia is characterized in that this pharmaceutical composition made by following raw material medicaments:
Hongqu powder (red colouring agent) 200 weight portion Fructus Crataegis 700 weight portions
Rhizoma Alismatis 300 weight portions.
3, a kind of pharmaceutical composition for the treatment of hyperlipemia is characterized in that this pharmaceutical composition made by following raw material medicaments:
Hongqu powder (red colouring agent) 150 weight portion Fructus Crataegis 750 weight portions
Rhizoma Alismatis 200 weight portions.
4, as claim 1,2 or 3 described preparation of drug combination methods, it is characterized in that this method is:
Fructus Crataegi, Rhizoma Alismatis are broken into coarse grain; Fructus Crataegi is used 60-90% alcohol reflux 2-3 time, doubly measure alcohol reflux with 6-12 at every turn, each 1-3 hour, merge alcohol extract, filter, concentrate, 50 ℃ of temperature are concentrated into the extractum that relative density is 1.20-1.25, with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder A gets dry extract; The Rhizoma Alismatis of alcohol extraction medicinal residues and formula ratio is mixed, with water boiling and extraction 2-3 time, with 5-10 times of water gaging reflux, extract, 1-3 hour, merge the water extract at every turn, filter, concentrate, 50 ℃ of temperature are concentrated into the extractum that relative density is 1.20-1.25, with this extractum vacuum drying, be dried to moisture less than 5%, with broken mistake 80 mesh sieves of dried cream powder, powder B gets dry extract; The aseptic Hongqu powder (red colouring agent) of dried cream powder A, dried cream powder B and formula ratio is mixed, get this pharmaceutical composition, this pharmaceutical composition can be made into tablet, granule, capsule, oral liquid, pill or the powder of clinical acceptance.
5, preparation of drug combination method as claimed in claim 4 is characterized in that this method is:
Fructus Crataegi, Rhizoma Alismatis are broken into coarse grain; Fructus Crataegi with 10 times of amount alcohol reflux, is measured alcohol reflux with 8 times for the first time for the second time with 80% alcohol reflux 2 times, each 2 hours, merge alcohol extract, filter, concentrate, 50 ℃ of temperature, be concentrated into the extractum that relative density is 1.20-1.25,, be dried to moisture less than 5% with this extractum vacuum drying, with broken mistake 80 mesh sieves of dried cream powder, powder A gets dry extract; The Rhizoma Alismatis of alcohol extraction medicinal residues and formula ratio is mixed, with water boiling and extraction 2 times, for the first time with 8 times of water gaging reflux, extract, 2 hours, for the second time with 6 times of water gaging reflux, extract, 1.5 hours, merge the water extract, filter, concentrate, 50 ℃ of temperature, be concentrated into the extractum that relative density is 1.20-1.25,, be dried to moisture less than 5% with this extractum vacuum drying, with broken mistake 80 mesh sieves of dried cream powder, powder B gets dry extract; The aseptic Hongqu powder (red colouring agent) of dried cream powder A, dried cream powder B and formula ratio is mixed, get this pharmaceutical composition, this pharmaceutical composition can be made into tablet, granule, capsule, oral liquid, pill or the powder of clinical acceptance.
6, preparation of drug combination method as claimed in claim 4 is characterized in that described capsule is a soft capsule; Described pill is a drop pill.
7, preparation of drug combination method as claimed in claim 5 is characterized in that described capsule is a soft capsule; Described pill is a drop pill.
8, as claim 1, the application of 2 or 3 described pharmaceutical compositions in the medicine of preparation treatment hyperlipemia.
9, has application in the medicine of effect for reducing blood fat as claim 1,2 or 3 described pharmaceutical compositions in preparation.
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| CN102172372B (en) * | 2011-01-12 | 2014-11-26 | 涂传荣 | Chinese medicinal preparation having function of lowering blood lipid |
| CN102670874B (en) * | 2011-03-14 | 2016-01-06 | 福建省医学科学研究院 | A kind of to medicative compound preparation of fatty liver and preparation method thereof |
| CN103372114B (en) * | 2012-04-20 | 2015-01-21 | 北京北大维信生物科技有限公司 | Red rice and rhizoma alismatis medicinal composition for regulating blood fat and preparation method of composition |
| CN103404759A (en) * | 2013-05-27 | 2013-11-27 | 胡安然 | Special diet for coronary heart disease patients |
| CN104172167A (en) * | 2014-08-20 | 2014-12-03 | 陕西华州医药生物工程有限公司 | Cholesterol-lowering functional food and preparation method thereof |
| CN106138683A (en) * | 2015-04-14 | 2016-11-23 | 李卓伦 | The medicine for the treatment of hyperlipemia |
| CN105876776A (en) * | 2016-03-24 | 2016-08-24 | 大兴安岭百盛蓝莓科技开发有限公司 | Black fungus, blueberry and red yeast rice ultrafine instant nutritious meal replacement powder and preparation method thereof |
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Address after: 044600 Fumin Road, Ruicheng, Shanxi, No. 43 Patentee after: Shanxi Yabao Pharmaceutical Group Corp. Address before: 044600 Fumin Road, Ruicheng, Shanxi, No. 43 Patentee before: Shanxi Yabao Pharmaceutical Co., Ltd. |
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Assignee: Yabao Group Taiyuan Pharmaceutical Co., Ltd. Assignor: Shanxi Yabao Pharmaceutical Group Corp. Contract record no.: 2011990000312 Denomination of invention: Traditional Chinese medicine composition for lowering blood-lipid, and method for preparing the same Granted publication date: 20100324 License type: Exclusive License Open date: 20071024 Record date: 20110426 |
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Assignee: Yabao Group Taiyuan Pharmaceutical Co., Ltd. Assignor: Shanxi Yabao Pharmaceutical Group Corp. Contract record no.: 2011990000312 Date of cancellation: 20110808 |