CN106220713B - 一种蝎毒耐热合成肽及其用途 - Google Patents

一种蝎毒耐热合成肽及其用途 Download PDF

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Publication number
CN106220713B
CN106220713B CN201610645111.7A CN201610645111A CN106220713B CN 106220713 B CN106220713 B CN 106220713B CN 201610645111 A CN201610645111 A CN 201610645111A CN 106220713 B CN106220713 B CN 106220713B
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scorpion venom
heat
peptide
scorpion
synthetic peptide
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Chinese (zh)
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CN106220713A (zh
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赵杰
李韶
张万琴
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Shanghai Wanjin Pharmaceutical Technology Co ltd
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Dalian Medical University
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Priority to CN201610645111.7A priority Critical patent/CN106220713B/zh
Publication of CN106220713A publication Critical patent/CN106220713A/zh
Priority to EP16905684.3A priority patent/EP3505530B1/en
Priority to JP2017554073A priority patent/JP6483858B2/ja
Priority to CA2984569A priority patent/CA2984569C/en
Priority to PCT/CN2016/112078 priority patent/WO2018028117A1/zh
Priority to ES16905684T priority patent/ES2945407T3/es
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Publication of CN106220713B publication Critical patent/CN106220713B/zh
Priority to US15/800,802 priority patent/US10442837B2/en
Priority to US16/573,495 priority patent/US10870680B2/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43522Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817Toxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3513Protein; Peptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201610645111.7A 2016-08-08 2016-08-08 一种蝎毒耐热合成肽及其用途 Active CN106220713B (zh)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201610645111.7A CN106220713B (zh) 2016-08-08 2016-08-08 一种蝎毒耐热合成肽及其用途
PCT/CN2016/112078 WO2018028117A1 (zh) 2016-08-08 2016-12-26 一种蝎毒耐热合成肽及其用途
JP2017554073A JP6483858B2 (ja) 2016-08-08 2016-12-26 サソリ毒耐熱合成ペプチド
CA2984569A CA2984569C (en) 2016-08-08 2016-12-26 A scorpion venom heat-resistant synthetic peptide and applications thereof
EP16905684.3A EP3505530B1 (en) 2016-08-08 2016-12-26 Scorpion venom heat-resistant synthesized peptide and uses thereof
ES16905684T ES2945407T3 (es) 2016-08-08 2016-12-26 Péptido sintético termorresistente del veneno de escorpión y aplicaciones del mismo
US15/800,802 US10442837B2 (en) 2016-08-08 2017-11-01 Scorpion venom heat-resistant synthetic peptide and applications thereof
US16/573,495 US10870680B2 (en) 2016-08-08 2019-09-17 Methods of reducing neuronal injury or toxicity in epilepsy, Alzheimer's disease or Parkinson's disease using a scorpion venom heat-resistant synthetic peptide (SVHRSP)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610645111.7A CN106220713B (zh) 2016-08-08 2016-08-08 一种蝎毒耐热合成肽及其用途

Publications (2)

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CN106220713A CN106220713A (zh) 2016-12-14
CN106220713B true CN106220713B (zh) 2017-09-01

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US (2) US10442837B2 (https=)
EP (1) EP3505530B1 (https=)
JP (1) JP6483858B2 (https=)
CN (1) CN106220713B (https=)
CA (1) CA2984569C (https=)
ES (1) ES2945407T3 (https=)
WO (1) WO2018028117A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106220713B (zh) * 2016-08-08 2017-09-01 大连医科大学 一种蝎毒耐热合成肽及其用途
CN109232718B (zh) * 2018-11-09 2020-04-14 泰安市启航生物科技有限公司 一种合成肽sp2及其应用
CN111647051B (zh) * 2019-03-04 2022-02-01 中国医科大学 一种基于钠通道结构的短肽及其应用
CN111896651B (zh) * 2020-07-30 2021-04-23 山东大学 一种白眉蝮蛇蛇毒类凝血酶特征多肽及其应用
CN114028537B (zh) * 2021-11-27 2024-03-29 上海万锦医药科技有限公司 一种含有svhrsp蝎毒肽的药物组合物及其制备方法
CN117224655B (zh) * 2023-09-14 2024-05-14 大连医科大学 蝎毒耐热合成肽(svhrsp)在制备治疗肠道炎症的药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1171595C (zh) * 2001-02-19 2004-10-20 大连高新园区全国高技术产业化微生态中试基地 获取无毒有效蝎毒的生产工艺及由该工艺制备的治疗癫痫的药物
US20030235902A1 (en) * 2001-12-13 2003-12-25 Kazuhiko Ishikawa Heat-resistant thioredoxin and related enzymes
CN100465272C (zh) * 2002-01-18 2009-03-04 中国科学院上海有机化学研究所 重组东亚马氏钳蝎毒rBmKaIT1的基因工程
CN100516217C (zh) * 2004-09-22 2009-07-22 山西大学 一种人工合成的蝎氯离子通道神经毒素基因-rBmK CTa
JP2009509535A (ja) * 2005-09-27 2009-03-12 アムニクス, インコーポレイテッド タンパク様薬剤およびその使用
CN1817902A (zh) * 2006-03-07 2006-08-16 山西大学 一种重组蝎昆虫毒素及其可溶性表达和纯化方法
CN101450966B (zh) * 2007-11-29 2012-06-27 武汉摩尔生物科技有限公司 一种抗耐药菌的多肽及用途
CN101284870B (zh) * 2008-06-03 2011-09-14 武汉大学 一种抗麻疹病毒和人免疫缺陷病毒的多肽及用途
CN103304630B (zh) * 2012-03-07 2014-09-17 中国科学院大连化学物理研究所 东亚钳蝎蝎毒中的gpcr活性多肽及其提取分离和应用
CN104341495A (zh) 2013-07-31 2015-02-11 张万琴 一种蝎毒耐热多肽和制备方法及其应用
CN106220713B (zh) * 2016-08-08 2017-09-01 大连医科大学 一种蝎毒耐热合成肽及其用途

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ES2945407T3 (es) 2023-07-03
EP3505530B1 (en) 2023-02-22
EP3505530A4 (en) 2020-04-29
US10870680B2 (en) 2020-12-22
EP3505530A1 (en) 2019-07-03
CA2984569A1 (en) 2018-02-08
US20180066019A1 (en) 2018-03-08
US10442837B2 (en) 2019-10-15
US20200002381A1 (en) 2020-01-02
WO2018028117A1 (zh) 2018-02-15
JP6483858B2 (ja) 2019-03-13
CA2984569C (en) 2019-10-22
JP2018529626A (ja) 2018-10-11
CN106220713A (zh) 2016-12-14

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