CN106188282B - 抗诺如病毒gi.1型鼠源单克隆抗体的制备和应用 - Google Patents

抗诺如病毒gi.1型鼠源单克隆抗体的制备和应用 Download PDF

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CN106188282B
CN106188282B CN201510219606.9A CN201510219606A CN106188282B CN 106188282 B CN106188282 B CN 106188282B CN 201510219606 A CN201510219606 A CN 201510219606A CN 106188282 B CN106188282 B CN 106188282B
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antibody
seq
present
variable region
heavy chain
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CN106188282A (zh
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黄忠
王晓黎
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Shanghai Institute of Immunology and Infection, Chinese Academy of Sciences
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Institut Pasteur of Shanghai of CAS
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Priority to PCT/CN2016/080795 priority patent/WO2016173559A1/fr
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
CN201510219606.9A 2015-04-30 2015-04-30 抗诺如病毒gi.1型鼠源单克隆抗体的制备和应用 Active CN106188282B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510219606.9A CN106188282B (zh) 2015-04-30 2015-04-30 抗诺如病毒gi.1型鼠源单克隆抗体的制备和应用
PCT/CN2016/080795 WO2016173559A1 (fr) 2015-04-30 2016-04-29 Préparation et utilisation de l'anticorps monoclonal murin contre le norovirus gi.1

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510219606.9A CN106188282B (zh) 2015-04-30 2015-04-30 抗诺如病毒gi.1型鼠源单克隆抗体的制备和应用

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CN106188282A CN106188282A (zh) 2016-12-07
CN106188282B true CN106188282B (zh) 2019-10-08

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CN (1) CN106188282B (fr)
WO (1) WO2016173559A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727488B (zh) * 2017-04-13 2022-07-22 中国科学院上海巴斯德研究所 抗诺如病毒gii.17单克隆抗体的制备和应用
CN109957014B (zh) * 2017-12-25 2022-03-29 中国科学院上海巴斯德研究所 抗诺如病毒gii.3鼠源单克隆抗体的制备和应用
JP7190674B2 (ja) * 2018-08-23 2022-12-16 パナソニックIpマネジメント株式会社 ノロウイルスに結合する抗体、複合体、それを用いた検出装置及び検出方法
CN109180810B (zh) * 2018-09-27 2021-05-07 国药中生生物技术研究院有限公司 特异性结合诺如病毒gi.1基因型vp1蛋白或vlp的抗体及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014126921A1 (fr) * 2013-02-12 2014-08-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux neutralisant les norovirus
CN104098698A (zh) * 2013-04-08 2014-10-15 中国人民解放军第二军医大学 一种抗cd3抗体及其制法和应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014126921A1 (fr) * 2013-02-12 2014-08-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux neutralisant les norovirus
CN104098698A (zh) * 2013-04-08 2014-10-15 中国人民解放军第二军医大学 一种抗cd3抗体及其制法和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus;Ajami NJ 等;《Clin Vaccine Immunol》;20121003;第19卷(第12期);第1980-1983页 *
诺如病毒衣壳蛋白单克隆抗体的制备及鉴定;郭丽 等;《中国人兽共患病学报》;20060531;第22卷(第5期);第414-418页 *

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WO2016173559A1 (fr) 2016-11-03
CN106188282A (zh) 2016-12-07

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Address after: Building 2, No. 225, Chongqing South Road, Huangpu District, Shanghai, 200025

Patentee after: Shanghai Institute of Immunology and Infection, Chinese Academy of Sciences

Address before: No. 411, Hefei Road, Huangpu District, Shanghai 200025

Patentee before: INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES

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