CN106177246A - Treat leukodermic compound ointment - Google Patents
Treat leukodermic compound ointment Download PDFInfo
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- CN106177246A CN106177246A CN201610728974.0A CN201610728974A CN106177246A CN 106177246 A CN106177246 A CN 106177246A CN 201610728974 A CN201610728974 A CN 201610728974A CN 106177246 A CN106177246 A CN 106177246A
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- fructus
- chinese medicine
- herba
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- ointment
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Abstract
The invention provides one and treat leukodermic compound ointment, its crude drug includes Herba Ecliptae, Fructus Ligustri Lucidi, Spica Prunellae, Caulis Spatholobi, Fructus Tribuli, Herba Spirodelae, Herba Menthae, Radix Glycyrrhizae, Fructus Psoraleae, Mylabris, Fructus Lycii, Flos Carthami, Radix Arnebiae (Radix Lithospermi), label grass, Bombyx Batryticatus, Semen Astragali Complanati and Caulis Vernoniae andersonii.The application of Chinese medicine compound ointment of the present invention have passed through long-term clinical observation checking, by the use in conjunction of Chinese medicine and western medicine, it is possible not only to promote functions of hormones, reduce the side effect of hormone, improve ultraviolet simultaneously and irradiate the facilitation that melanin is generated, reduce radiation damage, safely and effectively, it is adaptable to clinical expansion.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to one and treat leukodermic compound ointment.
Background technology
Vitiligo is a kind of common posteriority limit office's property or general property skin pigment depigmentation disease.Owing to the melanocyte of skin is thin
Born of the same parents' defunctionalization causes, but mechanism is not clear.The each position of whole body can occur, be common in finger the back of the body, wrist, forearm, face, neck and
Surrounding genital etc..Female genitalia also can occur, and young women is in the majority.
The generation of this disease, no significant difference in sex factor, each age group all can be fallen ill, but be sent out well with teenager.Skin
Damaging is depigmentation speckle, is often milky, it is possible to for lightpink, and smooth surface is without erythra.White macula boundary understands, edge pigment is relatively
Normal skin increases, and in white macula, hair is normal or bleaches.Pathological changes is apt to occur in is irradiated and damage by friction position by sunlight, and disease damage is multipair
Claim distribution.White macula the most often press nerve segment distribution and in zonation.In addition to skin lesion, in lip, labia, glans penis and foreskin
Side mucosa is the most often got involved.The many no conscious symptons of primary disease, small number of patients is at premorbid or has local, affected part scratchiness simultaneously.Vitiligo
Often accompany other autoimmune diseasees, as diabetes, thyroid disease, adrenal insufficiency, scleroderma, atoipc dermatitis,
Alopecia areata etc..Concrete typing is as follows:
1. topical type
(1) at focal type one or many places white macula is confined to a region, but it is not distributed in sections;
(2), at unilateral type (segmental pattern) one or many places white macula is sections distribution, suddenly disappear in midline;
(3) mucosa type only involves mucosa.
2. it is dispersed in type
(1) homeliness type extensively and is dispersed in the white macula of distribution;
(2) face acra type is distributed in face and extremity;
(3) mixed type segmental pattern, face acra type and/or homeliness type mixed distribution.
The most general hair style
Depigmentation all or almost all.The vitiligo of more than 90% is to be dispersed in type, topical type in remaining vitiligo
More more than general hair style.This disease can be divided into again perfect form and forme fruste two kinds according to depigmentation situation at disease damage.The former is to two
Oxamphetamine acid (DOPA) reaction negative, melanocyte disappears, and therapeutic response is poor.The latter is to DOPA reacting positive, melanocyte
The only number that do not disappears reduces, and cures probability big.
It is in addition to constitutional, often concurrently in diabetes, pernicious anemia, alopecia areata, atoipc dermatitis, thyroid disease, former
The property sent out Adrenal cortex function insufficiency, scleroderma, malignant tumor etc..
Being studied by Long-term clinical, doctor trained in Western medicine develops because be limited by its etiology and pathogenesis is unclear for primary disease, past
Toward being only capable of taking verification treatment, and its effect is the most unsatisfactory, its concrete Therapeutic Method such as:
1. Drug therapy:
(1) irradiation ultraviolet radiation after psoralen and derivant thereof such as methoxsalen is oral.
(2) megavitamin such as vitamin B complex, vitamin C, Citrin long-term taking.
(3) treatment such as the medicine of useful cupric such as 0.5% copper-bath is administered orally.
(4) immunomodulator levamisole is administered orally, lyophilized bacillus calmette-guerin vaccine (BCG) intramuscular injection, oral Bovine Placenta etc..
(5) skin irritant local is embrocated and is made skin be inflamed reaction, promotes pigment hypertrophy, and dust head has 30% Psoralen
Fat tincture, chlormethine ethanol, phenol (pure carbolic acid), 25%~50% trichloroacetic acid, Mylabris tincture etc..This method is only applicable to little split
Damage, after painting, at skin lesion, may occur in which bulla.
(6) the various corticosteroid hormone of corticosteroid hormone such as propanoic acid beclometasone ointment, halometasone cream, go inflammation
The local package treatments such as pine carbamide ointment.
2. operative treatment: patient's feasible AUTOEPIDERMIC GRAFTING operation that skin lesion stably gets nowhere.
3. decolouring therapy: be applicable to skin lesion area big, exceed more than half person of body surface area, available 3%~20% hydroquinone
Put on the skin outside single methyl phenyl ethers anisole frost.
4. physiotherapy: use narrow ripple ultraviolet, long wave ultraviolet or 308nm excimer laser treatment.
The Therapeutic Method of doctor trained in Western medicine mostly is ultraviolet irradiation and the external of hormone at present, and its effect is unstable, and has more
Untoward reaction,
The traditional Chinese medical science will be early than doctor trained in Western medicine for leukodermic understanding, note in Sui-Tang bines, " General Treatise on the Cause and Symptoms of Diseases " of Chao Yuanfang (550-630 A.D.)
Carry " leucoderma person, face and neck health skin and flesh complexion changed are white, the most not sufferings different from yellowish pink, the leucoderma of meaning "." Yizong Jinjian surgery
Heart method gist " record: " this disease bleaches suddenly from face and neck, yellowish pink, shape class speckle, not sufferings.If because following with the passing of time, even
Extend to all over ".Its etiology and pathogenesis is recognized the most relatively horn of plenty, concentrating on studies by ancient medicine, and its main cause of disease is sick
Machine is caused by hepatic stagnation qi stagnation, liver-kidney yin deficiency and qi stagnation and blood stasis type, and the incidence rate of clinical central three kinds of pattern of syndrome is the highest, without notable
Pattern of syndrome difference occurred frequently, exist between the most various pattern of syndrome and lapse to, therefore, traditional Chinese herb medicine of the present invention considers comprehensive etiology and pathogenesis
And the prevention change of disease, initiative is a kind of rules together for liver,spleen,kidney three is dirty, the double traditional Chinese herb medicine adjusted of QI and blood.
Chinese medicine preparation of the present invention, according to its etiology and pathogenesis and change of disease rule, by prescription medicine, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, is particularly adopted
Combining Western medicine, Transdermal absorption, local treatment with Chinese medicine, with local influence whole body, in the hope of thoroughly curing primary disease, ointment of the present invention leads to
Having crossed clinical experimental study and animal experiment study, carried out the system evaluation of safety, comprehensive consideration confirms that it is safe and effective,
It is applicable to clinical expansion.
Summary of the invention
The technical problem to be solved is to provide one and treats leukodermic compound ointment, according to its etiology and pathogenesis
And change of disease rule, by prescription medicine, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, combine Western medicine external, Transdermal absorption especially with Chinese medicine, local is controlled
Treat, with local influence whole body, in the hope of thoroughly curing primary disease.The application of Chinese medicine compound ointment of the present invention have passed through long-term clinical sight
Check card, by the use in conjunction of Chinese medicine and western medicine, be possible not only to promote functions of hormones, reduce the side effect of hormone, improve simultaneously
Ultraviolet irradiates the facilitation generated for melanin, reduces radiation damage.By the prescription essence to traditional Chinese herb medicine of the present invention
Letter and the optimization of dosage, passed through further clinical experimental study and animal experiment study, and the system having carried out safety is commented
Valency, comprehensive consideration confirms that it is safe and effective, it is adaptable to clinical expansion.
For solving above-mentioned technical problem, the present invention provides one to treat leukodermic compound ointment, and its crude drug includes halogen
Meter Song and Chinese medicine compound composition.
Wherein, the part by weight of described halometasone and Chinese medicine compound composition is 1: 18~1: 22.
Wherein, the crude drug of described Chinese medicine compound composition include Herba Ecliptae, Fructus Ligustri Lucidi, Spica Prunellae, Caulis Spatholobi, Fructus Tribuli,
Herba Spirodelae, Herba Menthae, Radix Glycyrrhizae, Fructus Psoraleae, Mylabris, Fructus Lycii, Flos Carthami, Radix Arnebiae (Radix Lithospermi), label grass, Bombyx Batryticatus, Semen Astragali Complanati and anthelmintic speckle
Turtledove chrysanthemum.
Wherein, in described Chinese medicine compound composition, the weight of each crude drug is most preferably respectively Herba Ecliptae 28g~32g, Fructus Ligustri Lucidi
Sub-13g~17g, Spica Prunellae 28g~32g, Caulis Spatholobi 28g~32g, Fructus Tribuli 10g~14g, Herba Spirodelae 8g~12g, Herba Menthae 6g~
10g, Radix Glycyrrhizae 13g~17g, Fructus Psoraleae 13g~17g, Mylabris 8g~12g, Fructus Lycii 13g~17g, Flos Carthami 8g~12g, purple
Grass 28g~32g, label grass 28g~32g, Bombyx Batryticatus 10g~14g, Semen Astragali Complanati 10g~14g and Caulis Vernoniae andersonii 13g~17g.
Wherein, in described Chinese medicine compound composition the weight of each crude drug most preferably be respectively Herba Ecliptae 30g, Fructus Ligustri Lucidi 15g,
Spica Prunellae 30g, Caulis Spatholobi 30g, Fructus Tribuli 12g, Herba Spirodelae 10g, Herba Menthae 8g, Radix Glycyrrhizae 15g, Fructus Psoraleae 15g, Mylabris 10g, Fructus Lycii
Sub-15g, Flos Carthami 10g, Radix Arnebiae (Radix Lithospermi) 30g, label grass 30g, Bombyx Batryticatus 12g, Semen Astragali Complanati 12g and Caulis Vernoniae andersonii 15g.
Present invention also offers the preparation method of above-mentioned compound ointment, including:
The first step, grinds to form the fine powder of 100 mesh by halometasone;
Second step, extracts Chinese medicine compound composition, grinds to form 100 mesh fine powders;
The Chinese medicine compound fine powder mixing that 3rd step, the halometasone fine powder first step obtained and second step obtain, takes 80g and mixes
Closing fine powder, add 200g Oleum Sesami and 30g vaseline, modulation is uniformly, it is thus achieved that compound ointment.
Described second step is specially further and is pulverized respectively by each crude drug, mixes, and adds mixture quality 10
The ethanol that determining alcohol is 80% again, heating and refluxing extraction 3 times, each 2h, merge alcohol extract, concentrating under reduced pressure removes ethanol, obtains
Get dry extract, grind to form 100 mesh fine powders.
Useful technique effect
What the present invention provided is used for treating leukodermic compound ointment, according to its etiology and pathogenesis and change of disease rule, by group
Side's medication, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, combine Western medicine external, Transdermal absorption especially with Chinese medicine, local is treated, with local influence whole body,
In the hope of thoroughly curing primary disease, ointment of the present invention has passed through clinical experimental study and animal experiment study, and carried out safety is
System is evaluated, and comprehensive consideration confirms that it is safe and effective, it is adaptable to clinical expansion.
Detailed description of the invention
The present invention provides one to treat leukodermic compound ointment, and its crude drug is by halometasone and Chinese medicine compound composition structure
Become.
The crude drug of described Chinese medicine compound composition is by Herba Ecliptae, Fructus Ligustri Lucidi, Spica Prunellae, Caulis Spatholobi, Fructus Tribuli, Herba Spirodelae, thin
Lotus, Radix Glycyrrhizae, Fructus Psoraleae, Mylabris, Fructus Lycii, Flos Carthami, Radix Arnebiae (Radix Lithospermi), label grass, Bombyx Batryticatus, Semen Astragali Complanati and Caulis Vernoniae andersonii structure
Become.
Leucoderma person, " face and neck health skin and flesh complexion changed are white, the most not sufferings different from yellowish pink, the leucoderma of meaning." at department of dermatologry
More typically, often showing as the depigmentation of skin mucosa, this old complaint is divided into limitation and general property two kinds according to morbidity scope, mainly
It is owing to melanocyte in skin and melanin granule substantially lack, causes epidermal melanophore to lose and produce skin depigmentation speckle.In vain
Purplish or white patches on the skin wind patient once physical weakness, unhappy, by external environment stimulation etc., endocrine regulation will be caused, body immunity
Decline, aggravation.The many employings of clinical treatment narrow ripple ultraviolet, long wave ultraviolet or 308nm excimer laser treatment, join simultaneously
Closing the external of hormone, but there is more serious side effect, ultra-vioket radiation is treated and be there is again certain uncertainty, and Chinese medicine pair
Long-standing in the understanding of this disease, by dialectical analysis medication, treatment, modern medicine study can be verified, part Chinese medicine has increasing
Darkening effect of colouring matter secretion, have simultaneously and increase the effect of ultraviolet sensitivity, external application Chinese medicine can reduce the side effect of hormone simultaneously,
Therefore, compound preparation of the present invention is by Chinese medicine and Western medicine use in conjunction, and Halometasone Cream can suppress melanocyte HLA-DR antigen, from
And control immunocyte infiltration and the release of inflammatory mediator, make melanocyte activate simultaneously, protect its pigment regeneration function, in
Medicine can take good care of QI and blood with invigorating liver and spleen kidney, increases the side effect after melanin generation, minimizing Corticosteroids, is now thought by its prescription
Road is presented below:
Vitiligo is a kind of common dermatosis being performance with skin limitation or Fan Fa hypopigmentation, clinical basis
The distribution of skin lesion or scope, can be divided into topical type, general hair style and whole body type.By its etiology and pathogenesis being analyzed summary, its
It mostly is strongly fragrant Qi-stagnation type, liver-kidney yin deficiency and qi depression to blood stasis pattern of syndrome, and without obvious single pattern of syndrome occurred frequently, therefore, they are many because of liver
The uncomfortable vitiligo caused of spleen kidney.Creative halometasone being combined with Chinese medicine compound composition, by grinding of Chinese medicine preparation of the present invention
Studying carefully discovery, the part by weight of halometasone and Chinese medicine compound composition is between 1: 18~1: 22, best proportion 1: 20, its action effect
Preferably.A small amount of Halometasone Cream can suppress melanocyte HLA-DR antigen, thus controls immunocyte infiltration and inflammation Jie
The release of matter, makes melanocyte activate simultaneously, protects its pigment regeneration function.We are for halometasone making in compound ointment
Consumption untoward reaction has carried out correlational study, when in compound ointment, halometasone consumption is higher, with the weight ratio of Chinese medicine compound composition
Example is more than 1: 15, it has been found that application site irritation symptom, such as burn feeling, pruritus.Rare: xerosis cutis, erythema, skin wither
Contracting, folliculitis, acne or pus, it is believed that when large area external or use sealing wrapping, corticosteroid enters blood
Circulation can produce systemic effect (the particularly temporary suppression of adrenal function), after disabling this product, these event resolves, because of
This uses halometasone to there may be bigger untoward reaction risk in a large number.
Chinese medicine compound composition with Fructus Ligustri Lucidi, Herba Ecliptae for monarch drug group, two medicine function liver and kidney tonifying, nourishing the liver blood, nourishing kidney-yin, phase
Must be use, modern medicine study, the active component contained in Fructus Ligustri Lucidi can regulate the immunologic function of cell, for endocrine system
System has a good regulation effect, simultaneously can strengthening the body resistance, black hair improving eyesight, Herba Ecliptae can crow must teeth consolidating, the traditional Chinese medical science thinks purple
It is diseases caused by exogenous pathogenic factor pyretic toxicity that outside line is irradiated, and still can cure the disease, but invades in then causing pyretic toxicity for excessive ultraviolet irradiation, and heat enters nutrient blood, and
Herba Ecliptae can be good at cooling blood for hemostasis, ultraviolet injury resistant, and therefore, two medicines share, play altogether increase melanin secretion, righting solid
Basis, effect of clearing away heat and cooling blood, for monarch drug;Leukodermic characteristics of incidence assumes a marked difference at stable phase and progressive stage.Enter
The duration of an exhibition vitiligo white macula expand, increased number, limitation transfer to distribute, general property, compare meet ailment said due to cold or exposure as " all kinds of diseases and ailments it
Long " feature such as " benefaction speed becomes, and easily attacks sun position ".Stable phase white macula circle is clear, around pigmentation occurs, and affected part hair bleaches, and adds
Enter Spica Prunellae, Caulis Spatholobi two medicine, Spica Prunellae heat clearing away suppressing the hyperactive liver, dispelling wind to relieve the exterior syndrome, have and preferably dissipate effect that wind is eliminating evil, and Caulis Spatholobi enters
Blood system, the stasis of bloods many for stable phase are presented with well verifying the effect for the treatment of, and two medicines share, and are ministerial drug group altogether;Additionally, add
Fructus Tribuli, Herba Menthae, assist ministerial drug Spica Prunellae to dissipate wind heat clearing away, suppressing the hyperactive liver resolving depression, effect of liver and kidney tonifying, its activation cheese ammonia of pharmaceutical research
The effect of phytase activity is notable, and addition Herba Spirodelae diaphoresis is dispeled the wind, heat-clearing and toxic substances removing, has preferable itching-relieving action, Fructus Lycii, Fructus Psoraleae
Liver and kidney tonifying, strong waist knee joint, wherein Fructus Psoraleae is the most selected as photosensitive drug, can strengthen photosensitization, promotes melanocyte
Synthesis, uses Semen Astragali Complanati liver and kidney tonifying, improving eyesight controlling nocturnal emission with astringent drugs, coordinates Fructus Lycii, Fructus Psoraleae, strengthens its kidney invigorating effect, promotes melanin
Generating, addition Mylabris, Flos Carthami assist ministerial drug Caulis Spatholobi promoting flow of QI and blood, nourish blood dissipating blood stasis, and wherein Mylabris is insect medicine, and property is walked to alter,
Removing blood stasis with potent drugs effect is relatively strong, and the treatment for stable phase patient has remarkable effect, uses and signs grass remove rheumatism, strong muscles and bones, clear
Thermal detoxification, for dermatosis, signs careless as characteristic medication, can well improve cutaneous manifestations, repair skin lesion, use purple
Grass has good removing heat from blood and promoting blood circulation, detoxicating functions, can increase melanin secretory function simultaneously, for ultraviolet irradiation treatment,
Contributing to protectiving ultraviolet injury, use Bombyx Batryticatus to have expelling wind for relieving convulsion, effect of dissipating phlegm and resolving masses, Bombyx Batryticatus is for causing because of hormone
Erythra, pruritus etc. have good mitigation, assist to dissipate wind except knot with the monarch and his subjects' medicine simultaneously, Caulis Vernoniae andersonii is Uygur medicine
The treatment topmost medical material of leukoderma, this medicine can activate internal TYR enzyme mRNA gene expression, can suppress body fluid simultaneously
Immunity, it can improve skin microcirculation blood flow etc. rich in various trace elements and rare element, be that the characteristic for the treatment of primary disease is used
Medicine, all medicines share, and are adjuvant drug altogether;Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinates ministerial drug Caulis Spatholobi, adjuvant drug Radix Arnebiae (Radix Lithospermi) etc. to have work of preferably detoxifying
Blood effect, Radix Glycyrrhizae share with the medicine such as Herba Spirodelae, Bombyx Batryticatus simultaneously, effectively reduces the skin pruritus caused because of hormone and other diseases
Shape, Radix Glycyrrhizae is used as coordinating the actions of various ingredients in a prescription simultaneously, for making medicine.Comprehensive analysis, Chinese medicine pharmacy of the present invention compound cream, Chinese and western medicine coordinates
Use, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, have good therapeutical effect for vitiligo, it is adaptable to clinical application.
Herba Ecliptae: have another name called Herba Ecliptae, ink grass, floods and droughts lotus, sweet in the mouth, acid, cold in nature, return liver, kidney channel, play not liver and kidney tonifying, cool
The effect of blood hemostasis, for having a dizzy spell caused by the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees;It is suitable for the deficiency of YIN and has hot person, be used for
The haematemesis of accumulated heat in treatment stomach, the hemoptysis of injury of blood vessel of the lung by heat etc. is demonstrate,proved.
Fructus Ligustri Lucidi: sweet in the mouth, hardship, is slightly cold, and enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treatment
Hepatic and renal YIN deficiency, the cards such as the head loses foster giddy tinnitus, yin asthenia generating intrinsic heat.
Spica Prunellae: bitter in the mouth, pungent, cold in nature, enter liver, gallbladder meridian, have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence, cure mainly conjunctival congestion
Swell and ache, mesh pearl nyctalgia, dizziness of having a headache, scrofula, goiter, swells and ache;Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension,
Hyperglycemia, hyperlipidemia and high blood viscosity etc. are demonstrate,proved.
Caulis Spatholobi: latin name SpatholobiCaulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, have expansion blood vessel, enrich blood
Invigorate blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, platelet aggregation is had obvious inhibitory action, promotes animal kidney and uterus total phosphorus
Metabolism, being mainly used in treating blood deficiency has the menoxenia of silt, and limbs pain is meciless, and soreness of the waist and knees, pain etc. are demonstrate,proved.
Fructus Tribuli: latin name TribulusterrestrisL. acrid in the mouth, hardship, slightly warm in nature, returns Liver Channel, and suppressing the hyperactive liver is soothing the liver, dispels the wind
Improving eyesight, treats excessive rising of liver-YANG, has a dizzy spell;Distending pain in the chest and hypochondrium, breast closes distending pain;Attack in wind heat, cataract;Rubella pruritus, leucoderma
Wind etc. are demonstrate,proved.
Herba Spirodelae: acrid in the mouth, cold in nature, to return lung meridian, there is the effects such as dispelling wind-heat, rash diuresis, cure mainly hot carbuncle, macule is impermeable,
Wind heat pain rash, skin pruritus, edema, amenorrhea, skin ulcer tinea, erysipelas, scald etc. is demonstrate,proved.
Herba Menthae: acrid in the mouth, cool in nature, enters lung, Liver Channel, has dispelling wind and heat pathogens, clear the profit head, sore-throat relieving rash, the merit of dispersing the stagnated live-QI to relieve the stagnation of QI
Effect, scratches where it itches from the beginning of, headache due to pathogenic wind-heat, the many tear of Ramulus et Folium Bischofiae Javanicae, laryngopharynx swelling and pain, measles without adequate eruption, rubella for affection due to external wind and heat or epidemic febrile disease, liver
The stagnation of QI is stagnant, and uncomfortable in chest not relaxing waits card.
Radix Glycyrrhizae: latin name GlycyrrhizaeRadixetRhizoma, sweet in the mouth, property is put down, is entered 12 warps, have heat clearing away solution
Poison, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, be mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach,
Weak;Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviate medicine to the toxic and side effects of body or
Gastrointestinal is stimulated, QI invigorating can be played neutralizes by adding Radix Glycyrrhizae, be in harmonious proportion the work of each component.
Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, enter kidney, spleen channel, have kidney invigorating and YANG supporting, warming spleen and stopping diarrha effect, be mainly used in the gate of vitality
Fire declines, the chills and pain of the waist and kness of below element deficiency and cold, frequent urination and enuresis, sexual impotence lingering diarrhea;Insufficiency of kidney-YANG, spleen soil lose using warming therapy stomachache limb and tremble with fear, diarrhea before dawn
The card such as rush down.
Mylabris: latin name Lyttavesicatoria, acrid in the mouth, property heat, return stomach warp, Liver Channel, kidney channel, there is removing blood stasis and disappear
Gargle, effect of dispersing pathogen accumulation, for abdominal mass lump, stubborn dermatitis for many years, scrofula, wart, the cards such as carbuncle do not bursts, the dead flesh of malignant boil.
Fructus Lycii: latin name lyciifructus, sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, benefit
Shrewd head, the effect of nourishing the lung to arrest cough, be mainly used in liver and kidney deficiency, the soreness of the waist and knees of asthenia of essence and blood, dizziness and tinnitus, seminal emission tinnitus,
Unconsciously sweat and tire;The sexual impotence of insufficiency of kidney-YANG, sterile;Deficiency of YIN-essence, deficiency of liver-blood eyes is dim-sighted and the card such as deficiency of YIN chronic cough.
Flos Carthami: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant abdomen of the stasis of blood
Bitterly, breast side of body twinge, traumatic injury, skin infection are swollen and ache curative effect.Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen, it is to avoid anemia of pregnant woman uses, otherwise
Miscarriage can be caused.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, one-tenth, GUIXIN, Liver Channel, there is removing heat from blood and promoting blood circulation, effect of removing toxic substances rash, cure mainly heat in blood poison contain,
Macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, blood
Drenching, dysentery, skin infection, erysipelas, burn, constipation with heat retention etc. is demonstrate,proved.
Herba Siegesbeckiae: latin name SiegesbeckiaeHerba, taste is cold, pungent, bitter, returns Liver Channel, kidney channel, has wind-damp dispelling, profit
Joint, effect of removing toxic substances, cure mainly that rheumatic arthralgia, muscles and bones be unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema etc.
Card.
Bombyx Batryticatus: acrid in the mouth, one-tenth, property is flat, enters liver, lung, stomach warp, has expelling wind to relieve convulsion, and effect of dissipating phlegm and resolving masses cures mainly apoplexy
Aphonia, infantile convulsion, wind syndrome of head, acute throat trouble, sore throat, scrofula tuberculosis, wind skin ulcer urticaria, erysipelas, mastitis etc. are demonstrate,proved.
Semen Astragali Complanati: warm in nature, sweet in the mouth, there is temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, the effect of improving eyesight, for impotence due to deficiency of the kidney, seminal emission
Premature ejaculation, frequent micturition, or leukorrhagia, soreness of the waist and knees, lumbago;Deficiency of the liver and kindey, the cards such as blurred vision mesh is dark, visual deterioration.
Caulis Vernoniae andersonii: bitter in the mouth, cool in nature, enter liver, large intestine channel.Clearing heat for detumescence, parasite killing treat tinea.For phlegm retention edema, arthralgia chiefly caused by damp pathogen
Pain, intestinal parasite, vitiligo.Such as laryngopharynx swelling and pain, conjunctival congestion and swelling pain, blood stasis swelling, traumatic injury, red swelling of the skin pain or scabies
The diseases such as skin ulcer, scabies, skin wrinkle.
In described Chinese medicine compound composition, the weight of each crude drug is most preferably respectively Herba Ecliptae 28g~32g, Fructus Ligustri Lucidi 13g
~17g, Spica Prunellae 28g~32g, Caulis Spatholobi 28g~32g, Fructus Tribuli 10g~14g, Herba Spirodelae 8g~12g, Herba Menthae 6g~10g, life
Radix Glycyrrhizae 13g~17g, Fructus Psoraleae 13g~17g, Mylabris 8g~12g, Fructus Lycii 13g~17g, Flos Carthami 8g~12g, Radix Arnebiae (Radix Lithospermi) 28g
~32g, label grass 28g~32g, Bombyx Batryticatus 10g~14g, Semen Astragali Complanati 10g~14g and Caulis Vernoniae andersonii 13g~17g.
In described Chinese medicine compound composition, to be most preferably respectively Herba Ecliptae 30g, Fructus Ligustri Lucidi 15g, summer withered for the weight of each crude drug
Grass 30g, Caulis Spatholobi 30g, Fructus Tribuli 12g, Herba Spirodelae 10g, Herba Menthae 8g, Radix Glycyrrhizae 15g, Fructus Psoraleae 15g, Mylabris 10g, Fructus Lycii
15g, Flos Carthami 10g, Radix Arnebiae (Radix Lithospermi) 30g, label grass 30g, Bombyx Batryticatus 12g, Semen Astragali Complanati 12g and Caulis Vernoniae andersonii 15g.
Present invention also offers the preparation method of above-mentioned compound ointment, including:
The first step, grinds to form the fine powder of 100 mesh by halometasone;
Second step, extracts Chinese medicine compound composition, grinds to form 100 mesh fine powders;
The Chinese medicine compound fine powder mixing that 3rd step, the halometasone fine powder first step obtained and second step obtain, takes 80g and mixes
Closing fine powder, add 200g Oleum Sesami and 30g vaseline, modulation is uniformly, it is thus achieved that compound ointment.
Described second step is specially further and is pulverized respectively by each crude drug, mixes, and adds mixture quality 10
The ethanol that determining alcohol is 80% again, heating and refluxing extraction 3 times, each 2h, merge alcohol extract, concentrating under reduced pressure removes ethanol, obtains
Get dry extract, grind to form 100 mesh fine powders.
Embodiment 1 Chinese medicine compound fine powder
By Herba Ecliptae 30g, Fructus Ligustri Lucidi 15g, Spica Prunellae 30g, Caulis Spatholobi 30g, Fructus Tribuli 12g, Herba Spirodelae 10g, Herba Menthae 8g, life
Radix Glycyrrhizae 15g, Fructus Psoraleae 15g, Mylabris 10g, Fructus Lycii 15g, Flos Carthami 10g, Radix Arnebiae (Radix Lithospermi) 30g, label grass 30g, Bombyx Batryticatus 12g, sand
The sub-12g in garden and Caulis Vernoniae andersonii 15g pulverizes respectively, mixes, and adds the ethanol that determining alcohol is 80% of 3kg, heats back
Stream extracts 3 times, each 2h, merges alcohol extract, and concentrating under reduced pressure removes ethanol, it is thus achieved that dry cream, grinds to form 100 mesh fine powders.
Embodiment 2 compound ointment 1
10g halometasone is ground to form the fine powder of 100 mesh, the Chinese medicine compound fine powder 200g of Example 1 preparation and halometasone
Grinding fine powder mixes, and takes 80g mixing fine powders, adds 200g Oleum Sesami and 30g vaseline, and modulation is uniformly, it is thus achieved that compound ointment 1.
Comparative example 1 compound ointment 2
Using method same as in Example 2 to prepare compound ointment 2, difference is in Chinese medicine compound fine powder not use ink
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae).
Comparative example 2 compound ointment 3
Using method same as in Example 2 to prepare compound ointment 3, difference is in Chinese medicine compound fine powder not use female
Loyal son.
Comparative example 3 compound ointment 4
Using method same as in Example 2 to prepare compound ointment 4, difference is in Chinese medicine compound fine powder not use female
Loyal son and Herba Ecliptae.
Long_term toxcity is tested
Leukodermic disease time is longer, and its treatment is the veryest long for the course for the treatment of, and Chinese medicine compound ointment of the present invention is worked as in clinic
In for external, every day 2 times, using continuously 14 days is a course for the treatment of, and treatment mostly was about 6 courses for the treatment of.By ingredient and join
Than detection, it meets country's relevant regulations, all within the scope of specified volume, and is external preparation, and its transdermal absorption factor is about
67%, its safety is relatively reliable.In order to verify the safety of Chinese medicine compound ointment of the present invention further, therefore long_term toxcity is set
Experiment.Its operation is as follows:
Adult healthy rat, 40, male and female half and half, test preposition animal in indoor adaptation environment one week, freely ingest and
Taking the photograph water, room temperature 18~22 DEG C, relative humidity 65~70%, alternately, before being administered, 24h is by back part of animal spinal column two to illuminate light and shade round the clock
Losing hair or feathers in side, unhairing scope is about as much as the 10% of body surface area.
The Chinese medicine compound ointment 1 of the embodiment of the present invention 2 preparation, 10g/ props up, and is 3.84g containing Effective Component of Chinese Medicine.
According to table of random number, rat is divided into matched group and experimental group.Experimental group is administered 3g/cm2, i.e. crude drug 1.15g/
cm2, dosage is that (normal human is administered normal dose 230.23 times, ointment 0.05g/cm2, people and mice be scaled 10.01:
1).Being coated on back part of animal and go to hair-fields by medicaments uniformity, drug of topical application thing is after 24 hours, and available warm water is observed, continuous 28 every day
My god.It is noted that animal systemic toxicity profiles shows and death condition, including the weight of animals, skin, hair, eyes and mucosa after administration
Change.The changes such as breathing, circulation, central nervous system, extremity activity.If meeting dead animal, needing to perform an autopsy on sb. and naked eyes are seen
Examine, when there being naked eyes lesions visible, then need to carry out pathological examination.
By long_term toxcity experimentation, observe situation after 28d rat coating, before administration, each treated animal body weight, feed,
Drinking-water situation no difference of science of statistics, after administration, each group rat body weight change, feed drinking-water situation, no difference of science of statistics.Behavioristics
, there is not death and other toxic reactions in Non Apparent Abnormality.
This experimental group dosage, is 230.23 times of clinical adult medication, and modern pharmacology is thought, for medicine long term toxicity
Experiment, completes successive administration week after date, and when occurring without overt toxicity response situation, this medicine is safe.Soft by the present invention
Cream long term toxicity test is verified, non-toxic reaction, it can be assumed that, the medication of this clinical drug is safe.
Clinical research
Physical data
Choosing first visit patient 150 example of self-institute vitiligo special outpatient clinic, consultation time is that in November, 2015 is to 2016
In April in year, clinic meets leukodermic diagnostic criteria, and (course of disease more than 1 month does not accepts for nearly 2 months to be sequentially selected in patient in outpatient service
Any treatment), carry out open clinical trial, every example is chosen skin lesion at 1~2 and is damaged as target, so as to observing therapeutic effect.Its
Middle male 78 example, women 72 example.Age 24~49 years old, average 37 years old.Stadium 2 months~11 years, average 22 months.All patients
Not accepting corticosteroid hormone, immunosuppressant, ultraviolet and light sensation Drug therapy in nearly 2 months, also not accepting other is
Rule and treat, without with other diseases.
Medicine and method: patient is labeled as 1 according to consultation time, 2,1,2 ... 1,2, be labeled as 1 for treatment group,
Be labeled as 2 for matched group, two groups, at the factors such as sex, age, stadium, patient's condition, statistics zero difference, can be compared.
Treatment group to the traditional Chinese herb medicine 1 prepared with the embodiment of the present invention 2, cutaneous lesion 2 times/day, 2 minor tick times >=
8h, follows up a case by regular visits to 1 time, and takes the photograph photo for every 1~2 week, to compare, to observe the state of an illness, and record curative effect and possible untoward reaction, 2 Zhou Weiyi
The individual course for the treatment of, 6 courses for the treatment of of Continuous Observation.
Matched group is given and Halometasone Cream, cutaneous lesion 2 times/day, 2 minor tick times >=8h, within every 1~2 week, follows up a case by regular visits to 1 time,
And take the photograph photo, to compare, to observe the state of an illness, record curative effect and possible untoward reaction, 2 weeks be a course for the treatment of, Continuous Observation 6 treatment
Journey.
Adjuvant drug, takes the circumstances into consideration with the use of vitamin B1, fursultiamine sheet, compound vitamin B and folic acid etc..
Two groups all assist treatment: ultraviolet irradiates, and exposes depigmentation position every day, irradiate 15 points under Burdick lamp
Clock, if depigmentation position is more, 3 positions maximum to depigmentation area are irradiated.
Therapeutic evaluation
Evaluation of clinical curative effect is divided into 4 grades: recovery from illness: white macula all disappears;Effective: white macula reduces, disappear >=50%;Effective:
White macula reduces, disappear < 50%;Invalid: white macula is unchanged or expands.
Safety evaluation
Overall merit is given according to Clinical Follow-up, untoward reaction record result.
Result
Stadium and comparitive study, the results are shown in Table 1.
Table 1 stadium and comparitive study
Through X 2 test, two groups of patient's stadium, curative effects are compared, for progressive stage, for progressive stage and steady
Periodically patient's curative effect, treatment group curative effect is superior to matched group, P < 0.05, has significant difference, and untoward reaction is less than comparison
Group, overall merit treatment group effect is more preferable.
The infringement of each position and comparitive study, the results are shown in Table 2.
The infringement of table 2 each position and comparitive study
Through X 2 test, the comparative study to two groups of patient's damaging parts, in buccal, socket of the eye week, accent, the treatment effect of cervical region
Fruit is significantly better than matched group, P < 0.05, has significant difference, and the improvement result at nose and other positions is close with matched group,
No difference of science of statistics, P > 0.05, overall merit treatment group effect is better than matched group.
Two groups of total effectses are evaluated
3 liang of table group total effects evaluation (%)
Stadium | Number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effective rate % |
Treatment group | 75 | 35 | 20 | 16 | 4 | 94.67* |
Matched group | 75 | 20 | 23 | 15 | 17 | 77.33 |
Compare with matched group, * P < 0.05
Through statistical analysis, Chinese medicine preparation of the present invention is not for the leukodermic effect matched group to be significantly better than that improves, and not
Good response rate relatively matched group substantially reduces, by improving the analysis of the situations such as the improvement of situation, treatment cycle for skin lesion, this
Invention Chinese medicine preparation clinical efficacy is notable, it is adaptable to clinical expansion.
Experimentation
Medicine: the compound ointment 1 of embodiment 2 preparation, the compound ointment 2 of comparative example 1 preparation, the compound recipe of comparative example 2 preparation
The compound ointment 4 of ointment 3, comparative example 3 preparation.
Material and method
Healthy male brown color Cavia porcellus 40, every laboratory animal back of weight 450g~560g take 10 from district
Territory, is randomly divided into 5 groups, and often group 8, is normal saline group, traditional Chinese herb medicine group of the present invention, comparable group 1, comparable group 2 respectively, compares
Group 3, smears guinea pig skin with traditional Chinese herb medicine of the present invention, each comparable group traditional Chinese herb medicine and normal saline.Every day 2 times, continuous 4 weeks, 4
Biopsy is taken after week.
Reagent and instrument
Cavia porcellus tryrosinase mRNA hybridization in situ detection kit, paraformaldehyde and poly-D-lysine, purchased from sea, Shen, Qingdao
Biotechnology company;The goat anti-rabbit igg diaminobenzidine of horseradish peroxidase-labeled and normal goat serum, be purchased from Qingdao
Qi Ao Bioisystech Co., Ltd;L-dopa amine is purchased from Sigma Co., USA;Pyrocarbonic acid diethyl ester and remaining is about material
It is import or domestic analytical reagent CryostatHM500 freezing microtome (Zeiss company of Germany) with reagent
The mRNA in situ hybridization of digoxigenin labeled
Experimental procedure is as follows:
Fresh isolated preparation makes, at-30 DEG C, the frozen section that thickness is 4~5 μm, the most first uses 0.1mol/
4% paraformaldehyde of LPBS preparation is fixed 45min and is then placed in the methanol solution containing 0.5% hydrogen peroxide by slide at 37 DEG C
The compound Digestive system that 3% citric acid is diluted by 30min is covered in slice surface digestion 2min.With 10 μ g/ μ l digoxigenin marks
The Probe In Situ Hybridization liquid 30 μ l of note drips in tested slice surface, hatches 90min.The PBS of ground control 0.5mol/L replaces
Probe.After 2 × SSC buffer solution, hatch 20min with hybrid stability liquid and confining liquid respectively;Incubate with rabbit anti digoxin antibody
Educate 60min, hatch respectively with the Streptavidin of biotinylation goat anti-rabbit igg confining liquid and horseradish peroxidase-labeled
20min.After DAB colour developing, H-E redyes, Microscopic observation.
Five in situ hybridization interpretations of result
In situ hybridization section and the corresponding ground control of observing each group under the high power lens visual field are cut into slices, and counting is at high power lens
Under in every 100 basal layer cells endochylema be the cell number of brown color and take pictures.Use HPIAS-1000 high-definition color simultaneously
Pathology picture and text are analyzed system and in situ hybridization section are carried out gray analysis, and every section randomly chooses 10 visuals field and measures its gray scale
Value.
Animal coloring element is tested
H-E dyes: the Histological change of light Microscopic observation specimen.
DOPA-oxidase dyeing: with DopA method, melanocyte is dyeed, calculate every 100 under high power lens
DOPA positive cell number in individual basal cell.
Containing melanin granule cell counting: dyeing melanin granule by Schmorl method, melanocyte is dyed to dark brown
Color.The cell number containing melanin granule in every 100 basal cells is counted under high power lens.
Data processing and inversion
The result of DOPA-oxidase dyeing and Schmorl method dyeing gained uses compatibility variance analysis, uses SPSS16.0
Software carries out data process.The dependency that melanocyte proliferation and melanogenesis two kinds are acted on by Chinese medicine uses Spearman grade
Correlation analysis.
Result
The Chinese medicine impact on tryrosinase mRNA level in-site of each group, the results are shown in Table 4.
Table 4 Positive Cell Counts and gray analysis result
Group | Positive cell number/100 basal cell | Gray value |
Invention group | 5.89±0.92** | 13.48±2.24** |
Relatively 1 group | 2.89±0.98# | 3.33±1.95# |
Relatively 2 groups | 5.05±0.89*# | 9.59±1.94*# |
Relatively 3 groups | 4.95±0.71*# | 8.39±0.86*# |
Normal saline group | 1.53±0.40 | 1.42±0.38 |
Compare with normal saline group,*P < 0.05,**P < 0.01;Compare with invention group,#P < 0.05
In situ hybridization result shows, after external respectively organizes traditional Chinese herb medicine, invention group and comparable group 2,3 all make Cavia porcellus tryrosinase
MRNA level in-site has to be increased in various degree, statistically significant with normal saline group comparing difference (P < 0.05), and comparable group 1 with
Normal saline group compares without significant difference, P > 0.05.Each group is compared with ointment of the present invention at positive cell number, gray value, all has
Notable significant difference, P < 0.05.
The Chinese medicine impact on Cavia porcellus coloring element effect of each group, the results are shown in Table 5.
Each group traditional Chinese herb medicine smears guinea pig skin, all makes skin pigmentation in various degree occur.Cut at H-EQ tissue
In sheet, in stratum basale and part spine cell, melanocyte seen from lower floor increases.Schmorl method dyes, it is seen that respectively organize traditional Chinese herb medicine
All can make (P < 0.05) Han melanin granule cytosis in guinea epidermis basal layer, seen from dopase dyeing, respectively organize Chinese medicine
In ointment makes guinea epidermis basal layer the most in various degree, DOPA positive cell increases (P < 0.05), two kinds of colouring method ethanol groups
And no significant difference (P > 0.05) between negative control group, the results are shown in Table 2
The coloring element effect to guinea pig skin of table 5 Chinese medicine
Compare with normal saline group,*P < 0.05,**P < 0.01;Compare with invention group,#P < 0.05
By the Chinese medicine research to guinea pig skin coloring element effect, traditional Chinese herb medicine of the present invention has fine blackening pigment and makees
With, hence it is evident that it is better than comparable group 1,2,3, and invention group (P < 0.01), comparable group 2,3 (P < 0.05) compare with matched group, have aobvious
Work difference, and comparable group 1 and normal saline group no difference of science of statistics, P > 0.05, illustrate less monarch drug group medicine, can cause making
With weakening, and remove monarch drug group two herbal medicine, then invent without obvious gain effect.
In sum, traditional Chinese herb medicine of the present invention passes through external, it is possible to well increase melanin pigmentation, and effective treatment is white
Purplish or white patches on the skin wind, after clinical research, can be used for clinical application.
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement limiting other forms
And/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar execution feelings
Condition.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.
Claims (9)
1. treat leukodermic compound ointment for one kind, it is characterised in that: crude drug includes halometasone and leukodermic for treating
Chinese medicine compound composition.
2. treat leukodermic compound ointment as claimed in claim 1, it is characterised in that: described halometasone and Chinese medicine compound composition
Part by weight be 1: 18~1: 22.
3. treat as claimed in claim 1 or 2 leukodermic compound ointment, it is characterised in that: described Chinese medicine compound composition former
Material medicine includes Herba Ecliptae, Fructus Ligustri Lucidi, Spica Prunellae, Caulis Spatholobi, Fructus Tribuli, Herba Spirodelae, Herba Menthae, Radix Glycyrrhizae, Fructus Psoraleae, Mylabris, Fructus Lycii
Son, Flos Carthami, Radix Arnebiae (Radix Lithospermi), label grass, Bombyx Batryticatus, Semen Astragali Complanati and Caulis Vernoniae andersonii.
4. as described in claims 1 to 3, treat leukodermic compound ointment, it is characterised in that: each in described Chinese medicine compound composition
The weight of crude drug is most preferably respectively Herba Ecliptae 28g~32g, Fructus Ligustri Lucidi 13g~17g, Spica Prunellae 28g~32g, Caulis Spatholobi
28g~32g, Fructus Tribuli 10g~14g, Herba Spirodelae 8g~12g, Herba Menthae 6g~10g, Radix Glycyrrhizae 13g~17g, Fructus Psoraleae 13g~
17g, Mylabris 8g~12g, Fructus Lycii 13g~17g, Flos Carthami 8g~12g, Radix Arnebiae (Radix Lithospermi) 28g~32g, label grass 28g~32g, Bombyx Batryticatus
Silkworm 10g~14g, Semen Astragali Complanati 10g~14g and Caulis Vernoniae andersonii 13g~17g.
5. as described in Claims 1-4, treat leukodermic compound ointment, it is characterised in that: each in described Chinese medicine compound composition
The weight of crude drug is most preferably respectively Herba Ecliptae 30g, Fructus Ligustri Lucidi 15g, Spica Prunellae 30g, Caulis Spatholobi 30g, Fructus Tribuli 12g, floats
Duckweed 10g, Herba Menthae 8g, Radix Glycyrrhizae 15g, Fructus Psoraleae 15g, Mylabris 10g, Fructus Lycii 15g, Flos Carthami 10g, Radix Arnebiae (Radix Lithospermi) 30g, label grass
30g, Bombyx Batryticatus 12g, Semen Astragali Complanati 12g and Caulis Vernoniae andersonii 15g.
6. the preparation method of compound ointment described in claim 1 to 5, it is characterised in that including:
The first step, grinds to form the fine powder of 100 mesh by halometasone;
Second step, extracts Chinese medicine compound composition, grinds to form 100 mesh fine powders;
The Chinese medicine compound fine powder mixing that 3rd step, the halometasone fine powder first step obtained and second step obtain, takes 80g mixing thin
Powder, adds 200g Oleum Sesami and 30g vaseline, and modulation is uniformly, it is thus achieved that compound ointment.
Described second step is specially further and is pulverized respectively by each crude drug, mixes, and adds mixture quality 10 times
Determining alcohol is the ethanol of 80%, heating and refluxing extraction 3 times, each 2h, merges alcohol extract, and concentrating under reduced pressure removes ethanol, it is thus achieved that dry
Cream, grinds to form 100 mesh fine powders.
7. one kind is used for treating leukodermic Traditional Chinese medicine compound composition, it is characterised in that: crude drug include Herba Ecliptae, Fructus Ligustri Lucidi,
Spica Prunellae, Caulis Spatholobi, Fructus Tribuli, Herba Spirodelae, Herba Menthae, Radix Glycyrrhizae, Fructus Psoraleae, Mylabris, Fructus Lycii, Flos Carthami, Radix Arnebiae (Radix Lithospermi), label grass,
Bombyx Batryticatus, Semen Astragali Complanati and Caulis Vernoniae andersonii.
It is used for the most as claimed in claim 7 treating leukodermic Traditional Chinese medicine compound composition, it is characterised in that: the weight of each crude drug
Most preferably it is respectively Herba Ecliptae 28g~32g, Fructus Ligustri Lucidi 13g~17g, Spica Prunellae 28g~32g, Caulis Spatholobi 28g~32g, thorn puncture
Herba chenopodii 10g~14g, Herba Spirodelae 8g~12g, Herba Menthae 6g~10g, Radix Glycyrrhizae 13g~17g, Fructus Psoraleae 13g~17g, Mylabris 8g~12g,
Fructus Lycii 13g~17g, Flos Carthami 8g~12g, Radix Arnebiae (Radix Lithospermi) 28g~32g, label grass 28g~32g, Bombyx Batryticatus 10g~14g, Sha Yuan
Sub-10g~14g and Caulis Vernoniae andersonii 13g~17g.
9. it is used for treating leukodermic Traditional Chinese medicine compound composition as described in claim 7 or 8, it is characterised in that: each crude drug
Weight is most preferably respectively Herba Ecliptae 30g, Fructus Ligustri Lucidi 15g, Spica Prunellae 30g, Caulis Spatholobi 30g, Fructus Tribuli 12g, Herba Spirodelae 10g, thin
Lotus 8g, Radix Glycyrrhizae 15g, Fructus Psoraleae 15g, Mylabris 10g, Fructus Lycii 15g, Flos Carthami 10g, Radix Arnebiae (Radix Lithospermi) 30g, label grass 30g, Bombyx Batryticatus
12g, Semen Astragali Complanati 12g and Caulis Vernoniae andersonii 15g.
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CN1264589A (en) * | 1999-02-26 | 2000-08-30 | 魏鹏 | Medicine for treating leukoderma and preparing process |
CN1931253A (en) * | 2006-09-13 | 2007-03-21 | 彭立新 | Leucoderma treating Chinese medicine |
CN101406641A (en) * | 2008-11-24 | 2009-04-15 | 黄玉英 | Compound medicament for treating vitiligo |
CN101474189A (en) * | 2009-01-20 | 2009-07-08 | 崔晓廷 | Halometasone medicinal preparation and preparation method |
CN104587323A (en) * | 2015-02-02 | 2015-05-06 | 王显勇 | Traditional Chinese medicine composition for treating leucoderma |
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2016
- 2016-08-26 CN CN201610728974.0A patent/CN106177246A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1264589A (en) * | 1999-02-26 | 2000-08-30 | 魏鹏 | Medicine for treating leukoderma and preparing process |
CN1931253A (en) * | 2006-09-13 | 2007-03-21 | 彭立新 | Leucoderma treating Chinese medicine |
CN101406641A (en) * | 2008-11-24 | 2009-04-15 | 黄玉英 | Compound medicament for treating vitiligo |
CN101474189A (en) * | 2009-01-20 | 2009-07-08 | 崔晓廷 | Halometasone medicinal preparation and preparation method |
CN104587323A (en) * | 2015-02-02 | 2015-05-06 | 王显勇 | Traditional Chinese medicine composition for treating leucoderma |
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Application publication date: 20161207 |