CN106176612A - 替米考星可溶性粉剂 - Google Patents

替米考星可溶性粉剂 Download PDF

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CN106176612A
CN106176612A CN201610744429.0A CN201610744429A CN106176612A CN 106176612 A CN106176612 A CN 106176612A CN 201610744429 A CN201610744429 A CN 201610744429A CN 106176612 A CN106176612 A CN 106176612A
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parts
tilmicosin
soluble powder
sodium
acid
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钟刚
陈砀桐
尚旭升
李显
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ANHUI HUAAO BIOTECHNOLOGY Pty Ltd
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ANHUI HUAAO BIOTECHNOLOGY Pty Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种替米考星可溶性粉剂。该替米考星可溶性粉剂由以下组分按重量份组成：替米考星1～20份，N‑酰基谷氨酸钠1～10份，天冬氨酸1～10份，三聚磷酸钠1～10份，酒石酸1～10份，葡萄糖40～94份。本发明解决了替米考星在水面漂浮难容问题，为养殖户提供使用方便的替米考星可溶性粉。

Description

替米考星可溶性粉剂
技术领域
本发明涉及一种替米考星可溶性粉剂。
背景技术
替米考星是兽药临床上的常用药物，但由于其水溶性差限制了它的的给药途径，造成临床应用不便，此外替米考星的苦味重，影响动物的采食量，也对兽医临床上的使用造成影响。目前增加替米考星在水中溶解性主要是加固体酸，但由于替米考星密度小，且非极性强在水面常成球状物漂浮，很难在短时间内溶解，使用时常常堵塞管道，造成不必要的麻烦。另外掩盖苦味较为有效的方法是将替米考星进行微囊包被，但解决不了其水溶性的问题。
发明内容
本发明要解决的技术问题是提供一种替米考星可溶性粉剂。
为解决上述技术问题，本发明采用的技术方案是：替米考星可溶性粉剂，由以下组分按重量份组成：
替米考星7～13份，N-酰基谷氨酸钠3～7份，天冬氨酸1～3份，三聚磷酸钠5～10份，酒石酸1～5份，葡萄糖62～83份。
作为优选，替米考星可溶性粉剂，由以下组分按重量份组成：
替米考星10份，N-酰基谷氨酸钠5份，天冬氨酸2份，三聚磷酸钠7份，酒石酸3份，葡萄糖73份。
本发明的有益效果是：
解决替米考星在水面漂浮难容问题，为养殖户提供使用方便的替米考星可溶性粉剂。
具体实施方式
实施例1
一种替米考星可溶性粉的配制，药物配制以每份1000g进行计算。替米考星可溶性粉组合物为：替米考星13份，N-酰基谷氨酸钠3份，天冬氨酸1份，三聚磷酸钠10份，酒石酸5份，葡萄糖68份。配制方法：按照重量称取替米考星13份、N-酰基谷氨酸钠3份，天冬氨酸1份，三聚磷酸钠10份，酒石酸5份；用77份葡萄糖作载体，原辅料充分搅拌均匀后即制成一种可溶性的替米考星可溶性粉。
取100mg该替米考星可溶性粉放入纳氏比色管中，加水50ml，上下翻转10次，在室温26℃中8min内完全溶解，半小时后没有浑浊及固体析出，溶液澄清。
实施例2
一种替米考星可溶性粉的配制，药品配制以每份1000g进行计算。替米考星可溶性粉组合物为：替米考星7份，N-酰基谷氨酸钠7份，天冬氨酸3份，三聚磷酸钠5份，酒石酸1份，葡萄糖77份。配制方法：按照重量称取替替米考星7份，N-酰基谷氨酸钠7份，天冬氨酸3份，三聚磷酸钠5份，酒石酸1份；用77份葡萄糖作载体，原辅料充分搅拌均匀后即制成一种可溶性的替米考星可溶性粉。
取100mg该替米考星可溶性粉放入纳氏比色管中，加水50ml，上下翻转10次，在室温26℃中17min内完全溶解，半小时后没有浑浊及固体析出，溶液澄清。
实施例3
一种替米考星可溶性粉的配制，药品配制以每份1000g进行计算。替米考星可溶性粉组合物为：替米考星10份、N-酰基谷氨酸钠5份、天冬氨酸2份、三聚磷酸钠7份、酒石酸3份、葡萄糖73份。配制方法：按照重量称取替米考星10份、N-酰基谷氨酸钠3份、天冬氨酸2份、三聚磷酸钠7份、酒石酸3份；用73份葡萄糖作载体，原辅料充分搅拌均匀后即制成一种可溶性的替米考星可溶性粉。
取100mg该替米考星可溶性粉放入纳氏比色管中，加水50ml，上下翻转10次，在室温26℃中3min内完全溶解，半小时后没有浑浊及固体析出，溶液澄清。
以上所述的本发明实施方式，并不构成对本发明保护范围的限定。任何在本发明的精神和原则之内所作的修改、等同替换和改进等，均应包含在本发明的权利要求保护范围之内。

Claims (2)

1.替米考星可溶性粉剂，其特征在于，由以下组分按重量份组成：
替米考星7～13份，N-酰基谷氨酸钠3～7份，天冬氨酸1～3份，三聚磷酸钠5～10份，酒石酸1～5份，葡萄糖62～83份。
2.根据权利要求1所述的替米考星可溶性粉剂，其特征在于，由以下组分按重量份组成：
替米考星10份，N-酰基谷氨酸钠5份，天冬氨酸2份，三聚磷酸钠7份，酒石酸3份，葡萄糖73份。
CN201610744429.0A 2016-08-29 2016-08-29 替米考星可溶性粉剂 Pending CN106176612A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101496811A (zh) * 2008-12-24 2009-08-05 天津瑞普生物技术股份有限公司 一种可溶且稳定的替米考星组合物
CN104473876A (zh) * 2014-11-26 2015-04-01 上海同仁药业有限公司 替米考星可溶性粉剂及其制备方法
CN104983686A (zh) * 2015-07-13 2015-10-21 胡涵 畜禽用美洛昔康可溶性粉剂及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101496811A (zh) * 2008-12-24 2009-08-05 天津瑞普生物技术股份有限公司 一种可溶且稳定的替米考星组合物
CN104473876A (zh) * 2014-11-26 2015-04-01 上海同仁药业有限公司 替米考星可溶性粉剂及其制备方法
CN104983686A (zh) * 2015-07-13 2015-10-21 胡涵 畜禽用美洛昔康可溶性粉剂及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张天胜: "《表面活性剂应用技术》", 30 September 2001, 化学工业出版社 *
李良铸等: "《最新生化药物制备技术》", 31 March 2001, 中国医药科技出版社 *

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