CN106174695A - The purposes of N nitrosamine compound in Fructus Momordicae charantiae extract and reduction cigarette smoke thereof - Google Patents
The purposes of N nitrosamine compound in Fructus Momordicae charantiae extract and reduction cigarette smoke thereof Download PDFInfo
- Publication number
- CN106174695A CN106174695A CN201610600467.9A CN201610600467A CN106174695A CN 106174695 A CN106174695 A CN 106174695A CN 201610600467 A CN201610600467 A CN 201610600467A CN 106174695 A CN106174695 A CN 106174695A
- Authority
- CN
- China
- Prior art keywords
- fructus momordicae
- momordicae charantiae
- nitrosamine
- extract
- cigarette
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2257/00—Components to be removed
- B01D2257/40—Nitrogen compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Materials Engineering (AREA)
- Cigarettes, Filters, And Manufacturing Of Filters (AREA)
Abstract
The present invention relates to Fructus Momordicae charantiae extract and reduce the purposes of N nitrosamine compound in cigarette smoke, specifically, described Fructus Momordicae charantiae extract is prepared by the following method and obtains: (1), by Fructus Momordicae charantiae supersound extraction in alcohols solvent, filters and collects filtrate；(2) filtrate collected in step (1) is concentrated, extraction, collect organic facies and be dried concentration, obtaining described Fructus Momordicae charantiae extract.It can reduce the content of the nitrosamine compound in main flume, can coordinate mutually with cigarette smoke simultaneously, and that improves flue gas returns sweet sense.
Description
Technical field
The present invention relates to Harm reduction techniques field, be specifically related to a kind of Fructus Momordicae charantiae extract, its preparation method and reducing volume
Purposes in N-nitrosamine compound in cigarette flue gas.
Background technology
Epidemiological study shows, smoking can cause the diseases such as Human Lung, bronchus, oral cavity.Nicotiana tabacum L. and flue gas are caused a disease
The factor mainly has multiring aromatic hydrocarbon, nitrosamines etc., wherein distinctive N-nitrosamine (tobacco-specific N-in Nicotiana tabacum L.
Nitrosamines, TSNAs) new with N-nitrosonornicotine (NNN), N-nitroso-group anabasine (NAB), N-nitroso-group
Nicoteine (NAT) and 4-(N-methyl-N-nitrosamine)-1-(3-pyridine radicals)-butanone (NNK) are main.This is that a class exists only in
N-nitrosamine compound in Nicotiana tabacum L. and flue gas, belongs to organ specificity carcinogen, has stronger carcinogenecity, its effect
First target organs is lung tissue, plays very important effect, thus become people and pay close attention in Nicotiana tabacum L. and flue gas associated diseases
Focus.Reduce the TSNAs content in cigarette smoke significant to improving safety cigarette.
In order to reduce the burst size of tobacco-specific nitrosamine, domestic and international Nicotiana tabacum L. researcher has done substantial amounts of research.South
Capital university Zhu Jianhua etc. discloses the novel mesoporous material (CN 101053446A) for absorbing nitrosamine in main flow flue gas in tobacco,
The mesoporous material of high absorption property is used as the interpolation material of cigarette filter stick, and adding material is by high viscosity, the liquid of difficult volatilization
Membranization compound spreads over the surfaces externally and internally of mesopore molecular sieve and forms, or the meso-porous molecular sieve material containing template micelle is used
In reducing the preparation method (CN 101053446A) of the mesopore molecular sieve of nitrosamine in main flume.In Hunan, cigarette discloses one
Plant and reduce cigarette filter of nitrosamine and aldehydes matter and preparation method thereof in cigarette smoke, utilize metal oxide modified activity
Carbon fibe is for reducing the nitrosamine in cigarette smoke and phenols (CN 101015394A).But, these mouth rods add material valency
Lattice are costly or preparation process relatively complicated difficult is for industrialized production, and its safety also needs further to be studied.Qiong Ni
R Williams discloses a kind of method (CN 1231583A) plant being carried out microwave radiation in drying stage, is used for reducing
NNN and NNK in Nicotiana tabacum L..Yuxi Hongta Nicotiana tabacum L. group sprays sodium alginate soln in process of production, reduces in main flume
Nitrosamine (CN1335107A).But the amount that tobacco-specific nitrosamine is removed by these methods is less and commercial production exists peace
Full hidden danger.
Summary of the invention
The present inventor, through great many of experiments and creative work, finds a kind of Fructus Momordicae charantiae extract, and it can be effective
Reducing the content of N-nitrosamine compound in cigarette smoke, the present invention is i.e. to complete based on above discovery.
The present invention relates to the following aspects:
1. the present invention relates to a kind of method preparing Fructus Momordicae charantiae extract, it comprises the following steps:
(1) by Fructus Momordicae charantiae supersound extraction in alcohols solvent, filter and collect filtrate；
(2) filtrate collected in step (1) is concentrated, extraction, collect organic facies and be dried concentration, obtaining described Fructus Momordicae charantiae and carry
Take thing.
In the certain preferred embodiments of the present invention, it is one or more that described preparation method has in following characteristics:
A., before step (1) described supersound extraction, the step that Fructus Momordicae charantiae is carried out pretreatment is also included:
Fructus Momordicae charantiae is pulverized, defat sieving；Preferably, described defat is carried out in ether；Preferably, sieve described in operation
Used by, the size of sieve is 20-60 mesh (such as 40 mesh)；
Preferably, also include first being carried out cutting into slices and dried before being pulverized by Fructus Momordicae charantiae；
B. alcohols solvent described in step (1) is selected from propylene glycol, glycerol, ethanol or their aqueous solution (such as 70%
Ethanol solution)；
C. described in step (1), in supersound extraction, the mass ratio of Fructus Momordicae charantiae powder and alcohols solvent is (1:5)-(1:20), such as
(1:5)-(1:15), such as 1:14；
D. described in step (1), the temperature of supersound extraction is 20-60 DEG C, such as 30-55 DEG C, such as 50 DEG C；Described ultrasonic
The time extracted is 5 minutes-2 hours, such as 10 minutes-1 hour, such as 30 minutes；
E. in step (2), extraction organic solvent used is n-butyl alcohol.
2. the invention still further relates to a kind of Fructus Momordicae charantiae extract, it is prepared by the method described in the present invention the 1st aspect.
3. the invention still further relates to Fructus Momordicae charantiae extract purposes in reducing cigarette smoke in N-nitrosamine compound；Preferably
Ground, described Fructus Momordicae charantiae extract is the Fructus Momordicae charantiae extract described in the present invention the 2nd aspect.
In the certain preferred embodiments of the present invention, described N-nitrosamine compound is selected from N-nitroso-group demethyl cigarette
Alkali (NNN), N-nitroso-group anabasine (NAB), N-nitrosoanatabine (NAT) and 4-(N-methyl-N-nitrosamine) amino-
1-(3-pyridine radicals)-butanone (NNK)；Preferably, described N-nitroso compound be 4-(N-methyl-N-nitrosamine) amino-
1-(3-pyridine radicals)-butanone.
4. the invention still further relates to a kind of reduce the method for N-nitrosamine compound in cigarette smoke, it includes described hardship
Melon extract adds the step in Medicated cigarette；Preferably, described Fructus Momordicae charantiae extract is added in cigarette filter.
In the certain preferred embodiments of the present invention, described N-nitrosamine compound is selected from N-nitroso-group demethyl cigarette
Alkali (NNN), N-nitroso-group anabasine (NAB), N-nitrosoanatabine (NAT) and 4-(N-methyl-N-nitrosamine) amino-
1-(3-pyridine radicals)-butanone (NNK)；Preferably, described N-nitroso compound be 4-(N-methyl-N-nitrosamine) amino-
1-(3-pyridine radicals)-butanone.
In a preferred embodiment of the invention, the addition of described Fructus Momordicae charantiae extract is 1-50mg, such as 1-30mg, example
Such as 1-20mg, preferably 5-15mg.
5. the invention still further relates to a tobacco articles, it contains Fructus Momordicae charantiae extract of the present invention.
In the certain preferred embodiments of the present invention, described tobacco product is Medicated cigarette；It is highly preferred that it is the cigarette of Medicated cigarette
Silk, thin slice, internal lining paper or filter stick；It is highly preferred that it is the filter stick of Medicated cigarette.
The beneficial effect of the invention
The present invention provides a kind of Fructus Momordicae charantiae extract, and it can reduce the content of the nitrosamine compound in main flume.It addition,
Fructus Momordicae charantiae extract can be coordinated mutually with cigarette smoke, and that improves flue gas returns sweet sense.
Accompanying drawing explanation
When accompanying drawing 1 display detection wavelength is 203.4nm, the HPLC figure of Fructus Momordicae charantiae extract of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be
Can by city available from conventional products.
The preparation of embodiment 1 Fructus Momordicae charantiae extract
By Fructus Momordicae charantiae cut into slices, be dried, pulverize after after ether defatting cross 40 mesh sieves obtain Fructus Momordicae charantiae powder, then 50 DEG C, ultrasonic
Power is that Fructus Momordicae charantiae powder is by Fructus Momordicae charantiae powder supersound extraction 40～50min in 70% ethanol under conditions of 108W with volumetric concentration
The mass ratio of the ethanol of 70% is 1: 14, filters, and after filtrate concentration, n-butanol extraction, is dried, concentrates, and obtains Fructus Momordicae charantiae and extracts
Thing, for brown oil.
Fructus Momordicae charantiae extract is based on saponin and acid ingredient after testing, and it is mainly composed of Charantin glycosides F1
(Momordicoside FI), Charantin glycosides l (Momordicoside I), Charantin glycosides G (Momordicoside G), Fructus Momordicae charantiae
Saponin A (MomordicosideA), Momordica charantial B (Momordicoside B), Charantin, eleostearic acid, butanoic acid, Palmic acid, tristearin
Acid, lauric acid, linoleic acid, myristic acid, linolenic acid etc..Accompanying drawing 1 is the HPLC figure of Fructus Momordicae charantiae extract, and concrete test condition is such as
Under:
INSTRUMENT MODEL: liquid chromatograph, Agilent LC1260；
Chromatographic column: Eclipse Plus C18 150*4.6mm, 5um；
Column temperature: 25 DEG C；
Sample size: 5uL；
Flow velocity: 1mL/min；
Flowing phase: acetonitrile and water；
Elution program: 0min, acetonitrile 10%；40min, acetonitrile 40%；50min, acetonitrile 40%；51min, acetonitrile 95%；
55min, acetonitrile 95%；56min, acetonitrile 10%；
Detection wavelength: 203nm.
Embodiment 2
The most slowly being injected in the middle part of cigarette filter core by the Fructus Momordicae charantiae extract that embodiment 1 prepares, addition is
5mg；Cigarette machine simulation suction is carried out with unprocessed sample；Liquid chromatography tandem mass spectrometry is used to measure in cigarette mainstream flue gas
The content of NNK.
Subordinate list 1 reduces the effectiveness comparison of NNK in main flume
| Fructus Momordicae charantiae extract addition | NNK (ng/ props up) | Average rate of decrease % |
| 0 | 5.3 | |
| 5mg | 3.7 | 47.17% |
Embodiment 3
The most slowly being injected in the middle part of cigarette filter core by the Fructus Momordicae charantiae extract that embodiment 1 prepares, addition is
10mg；Cigarette machine simulation suction is carried out with unprocessed sample；Liquid chromatography tandem mass spectrometry is used to measure cigarette mainstream flue gas
The content of middle NNK.
Subordinate list 2 reduces the effectiveness comparison of NNK in main flume
| Fructus Momordicae charantiae extract addition | NNK (ng/ props up) | Average rate of decrease % |
| 0 | 5.3 | |
| 10mg | 2.8 | 30.18% |
Embodiment 4
The most slowly being injected in the middle part of cigarette filter core by the Fructus Momordicae charantiae extract that embodiment 1 prepares, addition is
15mg；Cigarette machine simulation suction is carried out with unprocessed sample；Liquid chromatography tandem mass spectrometry is used to measure cigarette mainstream flue gas
The content of middle NNK.
Subordinate list 3 reduces the effectiveness comparison of NNK in main flume
| Fructus Momordicae charantiae extract addition | NNK (ng/ props up) | Average rate of decrease % |
| 0 | 5.3 | |
| 15mg | 2.1 | 60.38% |
Embodiment 5
The most slowly being injected in the middle part of cigarette filter core by the Fructus Momordicae charantiae extract that embodiment 1 prepares, addition is
10mg, carries out sensory evaluating smoking's experiment according to GB GB5606.4 2005 " requirement of Medicated cigarette sense organ technology " to cigarette sample, and result is such as
Under:
Experimental result shows, compared with blank Medicated cigarette, Fructus Momordicae charantiae extract is coordinated mutually with cigarette smoke, and the sweet sense of returning of flue gas carries
High.
Although the detailed description of the invention of the present invention has obtained detailed description, according to disclosed all teachings, this
Skilled person can carry out various amendment and replacement to the details of technical solution of the present invention, and these change all the present invention's
Within protection domain.The four corner of the present invention is given by claims and any equivalent thereof.
Claims (9)
1. the preparation method of Fructus Momordicae charantiae extract, it comprises the following steps:
(1) by Fructus Momordicae charantiae supersound extraction in alcohols solvent, filter and collect filtrate；
(2) filtrate collected in step (1) is concentrated, extraction, collect organic facies and be dried concentration, obtain described Fructus Momordicae charantiae and extract
Thing.
2. the preparation method of claim 1, it is one or more that it has in following characteristics:
A., before step (1) described supersound extraction, the step that Fructus Momordicae charantiae is carried out pretreatment is also included:
Fructus Momordicae charantiae is pulverized, defat sieving；Preferably, described defat is carried out in ether；Preferably, sieve described in operation in institute
It is 20-60 mesh (such as 40 mesh) by the size of sieve；
Preferably, before being pulverized by Fructus Momordicae charantiae, also include the step that Fructus Momordicae charantiae is carried out section and dried；
B. alcohols solvent described in step (1) is selected from propylene glycol, glycerol, ethanol or their aqueous solution (such as 70% ethanol
Solution)；
C. described in step (1), in supersound extraction, the mass ratio of Fructus Momordicae charantiae powder and alcohols solvent is (1:5)-(1:20), such as (1:
5)-(1:15), such as 1:14；
D. described in step (1), the temperature of supersound extraction is 20-60 DEG C, such as 30-55 DEG C, such as 50 DEG C, and the time is 5 minutes-2
Hour, such as 10 minutes-1 hour, such as 30 minutes；
E. in step (2), extraction organic solvent used is n-butyl alcohol.
3. a Fructus Momordicae charantiae extract, it is prepared by the method for claim 1 or 2.
4. Fructus Momordicae charantiae extract purposes in N-nitrosamine compound in reducing cigarette smoke；Preferably, described Fructus Momordicae charantiae extracts
Thing is the Fructus Momordicae charantiae extract described in claim 3.
5. the purposes of claim 4, wherein said N-nitrosamine compound is selected from N-nitrosonornicotine (NNN), N-
Nitroso-group anabasine (NAB), N-nitrosoanatabine (NAT) and 4-(N-methyl-N-nitrosamine) amino-1-(3-pyridine
Base)-butanone (NNK)；Preferably, described N-nitroso compound is 4-(N-methyl-N-nitrosamine) amino-1-(3-pyridine
Base)-butanone.
6. reducing a method for N-nitrosamine compound in cigarette smoke, it includes carrying the Fructus Momordicae charantiae described in claim 3
Take thing and add the step in Medicated cigarette；Preferably, the Fructus Momordicae charantiae extract described in claim 3 is added in cigarette filter；Preferably,
The addition of described Fructus Momordicae charantiae extract is 1-50mg, such as 1-30mg, such as 1-20mg, preferably 5-15mg.
7. the method for claim 6, wherein said N-nitrosamine compound is selected from N-nitrosonornicotine (NNN), N-
Nitroso-group anabasine (NAB), N-nitrosoanatabine (NAT) and 4-(N-methyl-N-nitrosamine) amino-1-(3-pyridine
Base)-butanone (NNK)；Preferably, described N-nitroso compound is 4-(N-methyl-N-nitrosamine) amino-1-(3-pyridine
Base)-butanone.
8. a tobacco articles, it contains the Fructus Momordicae charantiae extract described in claim 3.
9. the tobacco product of claim 8, it is the tobacco shred of Medicated cigarette, such as Medicated cigarette, thin slice, internal lining paper or filter stick；Preferably, its
Filter stick for Medicated cigarette.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610600467.9A CN106174695A (en) | 2016-07-28 | 2016-07-28 | The purposes of N nitrosamine compound in Fructus Momordicae charantiae extract and reduction cigarette smoke thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610600467.9A CN106174695A (en) | 2016-07-28 | 2016-07-28 | The purposes of N nitrosamine compound in Fructus Momordicae charantiae extract and reduction cigarette smoke thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106174695A true CN106174695A (en) | 2016-12-07 |
Family
ID=57496315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610600467.9A Pending CN106174695A (en) | 2016-07-28 | 2016-07-28 | The purposes of N nitrosamine compound in Fructus Momordicae charantiae extract and reduction cigarette smoke thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106174695A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111972697A (en) * | 2020-09-18 | 2020-11-24 | 河南农业大学 | Application of menthone in reducing content of tobacco-specific nitrosamines in cigar fermentation process |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101358954A (en) * | 2008-07-14 | 2009-02-04 | 天津农学院 | Establishment for HPLC fingerprint of balsam pear saponin |
| CN102030795A (en) * | 2010-11-30 | 2011-04-27 | 哈尔滨商业大学 | Cucurbitane momordicoside and preparation method thereof |
| CN102763899A (en) * | 2012-07-27 | 2012-11-07 | 红云红河烟草(集团)有限责任公司 | Application of bitter gourd in cigarette |
| CN103351420A (en) * | 2013-07-03 | 2013-10-16 | 沈阳药科大学 | Compound obtained from Momordica charantia L. through separation and preparation method and application thereof |
| CN104522880A (en) * | 2014-12-25 | 2015-04-22 | 鹰潭华宝香精香料有限公司 | Composite plant extract and preparation method thereof |
-
2016
- 2016-07-28 CN CN201610600467.9A patent/CN106174695A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101358954A (en) * | 2008-07-14 | 2009-02-04 | 天津农学院 | Establishment for HPLC fingerprint of balsam pear saponin |
| CN102030795A (en) * | 2010-11-30 | 2011-04-27 | 哈尔滨商业大学 | Cucurbitane momordicoside and preparation method thereof |
| CN102763899A (en) * | 2012-07-27 | 2012-11-07 | 红云红河烟草(集团)有限责任公司 | Application of bitter gourd in cigarette |
| CN103351420A (en) * | 2013-07-03 | 2013-10-16 | 沈阳药科大学 | Compound obtained from Momordica charantia L. through separation and preparation method and application thereof |
| CN104522880A (en) * | 2014-12-25 | 2015-04-22 | 鹰潭华宝香精香料有限公司 | Composite plant extract and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111972697A (en) * | 2020-09-18 | 2020-11-24 | 河南农业大学 | Application of menthone in reducing content of tobacco-specific nitrosamines in cigar fermentation process |
| CN111972697B (en) * | 2020-09-18 | 2021-08-13 | 河南农业大学 | Application of menthone in reducing content of tobacco-specific nitrosamines in cigar fermentation process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103989244B (en) | A kind of Chinese style tobacco juice for electronic smoke and preparation method thereof | |
| KR100296868B1 (en) | Tobacco without nicotine | |
| CN101731748A (en) | Method for extracting Dendranthema indium leaves and application of extractive thereof in cigarettes | |
| CN101538260B (en) | Isoflavone compound and prepration method and application thereof | |
| CN102994231A (en) | Preparation method of flavor for baicalin tobaccos | |
| CA2905232A1 (en) | Methods for reducing one or more tobacco specific nitrosamines in tobacco material | |
| CN106263023B (en) | A kind of cigarette filter composition can be effectively reduced tar and content of nitrosamines | |
| CN104939291A (en) | Method for enhancing inherent aroma of tobaccos by aid of natural plants | |
| CN102031194A (en) | Ginkgo leaf volatile oil extraction method and method for flavoring cigarettes by utilizing volatile oil | |
| CN102703217A (en) | Noni extract and application thereof | |
| CN110982625A (en) | Licorice-flavored dried beads for cigarette filter tips and preparation method thereof | |
| CN106174695A (en) | The purposes of N nitrosamine compound in Fructus Momordicae charantiae extract and reduction cigarette smoke thereof | |
| CN109953367A (en) | A kind of Herba Cistanches extracting solution and preparation method thereof, composition and application | |
| CN103789090A (en) | Flowering tobacco volatile extraction method and preparation method for microcapsules of flowering tobacco | |
| CN105029700A (en) | Plant composite glycerol triacetate extract and application thereof in cigarettes | |
| CN105341998B (en) | A kind of method that utilization microwave auxiliary extraction prepares electronic cigarette liquid | |
| CN105018231B (en) | A kind of cigarette peel extract and application | |
| CN104705777B (en) | A kind of tobacco juice for electronic smoke containing natural built-up thing | |
| CN108523221B (en) | Composite cigarette filter rod prepared from momordica grosvenori leaves and preparation method thereof | |
| CN104687243A (en) | Natural compound humectant with cigarette sensory humectation function | |
| CN103980380B (en) | Fructus Alpiniae Oxyphyllae polysaccharide, method for extraction and purification and the application as tobacco humectant thereof | |
| CN105029699A (en) | Mint glycerol triacetate extract and application thereof in cigarette | |
| CN112813111B (en) | Method for preparing antioxidation functional ginger powder by micro-fermentation technology | |
| CN112772962B (en) | Cut tobacco and cigarette containing aquilaria sinensis extract and preparation method thereof | |
| KR20100049342A (en) | Perfume composition for expressing the fragrance of nelumbo nucifera |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161207 |