CN106166290A - A kind of Chinese herbs paste treating infantile pneumonia - Google Patents

A kind of Chinese herbs paste treating infantile pneumonia Download PDF

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Publication number
CN106166290A
CN106166290A CN201610832926.6A CN201610832926A CN106166290A CN 106166290 A CN106166290 A CN 106166290A CN 201610832926 A CN201610832926 A CN 201610832926A CN 106166290 A CN106166290 A CN 106166290A
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patch
cortex phellodendri
moulding material
herba
ethanol
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刘富岗
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The present invention relates to a kind of Chinese herbs paste treating infantile pneumonia, can effectively solve existing medicine big to infantile pneumonia treatment side effect, Transdermal absorption is poor, the problem of the easy allergy of children's's skin.The technical scheme solved is that Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis are mixed extraction volatile oil；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A mix manufacture of pharmaceutical components A；Take Cortex Phellodendri and prepare alkaloid；Take drug component A, medical polypropylene acid sodium, sodium carboxymethyl cellulose, pharmagel, tragacanth, water are mixed and made into patch moulding material I；Separately take Cortex Phellodendri alkaloid extract, volatile oil, carbomer, water make patch moulding material II；Patch moulding material II and patch moulding material I are mixed and made into patch, the Chinese herbs paste of infantile pneumonia must be treated.Compatibility of the present invention is reasonable, determined curative effect, and life-time service side effect is little, and water content is high, and without allergic phenomena, economic and social benefit is notable.

Description

A kind of Chinese herbs paste treating infantile pneumonia
Technical field
The present invention relates to field of medicaments, a kind of Chinese herbs paste treating infantile pneumonia.
Background knowledge
Infantile pneumonia is by pathogenic infection or to suck the pneumonia caused by amniotic fluid and oils and anaphylaxis etc., main Wanting clinical manifestation is heating, cough, rapid breathing, dyspnea and pulmonary's sound etc..Infantile pneumonia is also children's acute heat One of modal disease in disease, is in Pediatric Clinic and inpatient's number is the first, the most substantial amounts of in therapeutic process Application antibiotics, not only medical expense height further increases the misery of infant, and usually makes virus and mycoplasma pneumoniae Produce endurance strain, immune dysfunction energy harmful effect.
For solving problems, through a large amount of clinical practices, applicant finds that Chinese medicine external has in terms of preventing and treating infantile pneumonia Good efficacy.Acupoint application of Chinese herb treatment disease of cough and asthma, makes drug percutaneous penetrate, through acupuncture point going from the exterior into the interior, reaches dirty in following meridians Internal organs, with regulation negative and positive of qi and blood balance, reaches to treat the purpose of disease.Numerous studies show, children's's subcutaneous fat is few, and thoracic wall is thin, easily In the absorption of percutaneous dosing, therefore the present invention uses Chinese medicine compound to make the external use plaster of percutaneous dosing for treating Lungs of Children Scorching.Owing to children's bears a pretty, delicate skin easy allergy, the present invention is with hydrophilic high molecular material as substrate, it is to avoid use tradition The stimulation to skin of the traditional fat-soluble substrate such as rubber-emplastrum, hot-fusible pressure-sensitive adhesive, the most less phenomena of cutaneous irritation.In order to Solving the difficult problem that percutaneous absorbtion is difficult to absorb, the present invention is classified extracting separating treatment to Chinese medicine compound, to the full extent The effective ingredient remaining prescription solves the problem that percutaneous dosing absorption efficiency is low simultaneously, considerably increases drug effect.
For the problems referred to above, present invention research also proposes a kind of Chinese herbs paste treating infantile pneumonia.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the purpose of the present invention is just to provide one and treats Lungs of Children Scorching Chinese herbs paste, side effect is big to infantile pneumonia treatment cycle length can effectively to solve existing medicine, and existing patch transdermal is inhaled Astigmat, the problems such as drug effect is low, children's's easy allergy of skin.
The technical scheme is that, a kind of Chinese herbs paste treating infantile pneumonia, by the material medicine of following weight meter Make: Cortex Magnoliae Officinalis 70-80g, 70-80g Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae) 70-80g, Bulbus Fritillariae Thunbergii 70-80g, Flos Farfarae 70-80g, Caulis Lonicerae 70- 80g, Herba Solani Nigri 70-80g, Rhizoma Zingiberis 70-80g, Cortex Phellodendri 90-100g, Flos Caryophylli 60-70g, Radix Bupleuri 70-80g, Herba Houttuyniae 80-90g, Herba Menthae 60-70g, wherein, mixes Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis, extracts volatilization with supercritical fluid extraction Oil, concretely comprises the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixing, pulverize, put into supercritical extraction unit, according to Lower condition extracts: extraction temperature 38 DEG C, extracting pressure 20MPa, extraction time 120min, CO2Flow 17L/h, extraction gained is waved Hair oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A Mix, add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A weight 10-16 times amount Volumetric concentration is the ethanol of 70%-95%, extracts 2 times with flash extracter, each 1-3min, filters, and merging filtrate, 50 DEG C subtract It is 1.06-1.12 that pressure is concentrated into proportion, and lyophilization obtains drug component A, standby；Take Cortex Phellodendri pulverizing medicinal materials, add Cortex Phellodendri medical material The ethanol solution that pH2.5 volumetric concentration is 50% of weight 15 times 25 DEG C soaks 8h, 95 DEG C of reflux, extract, 3h, filters, and filtrate subtracts It is 1.08-1.15 that pressure is concentrated into proportion, and storng-acid cation exchange resin on concentrated solution, with the volumetric concentration containing 1mol/L ammonia Be 70% ethanol solution carry out eluting, eluent is adjusted to pH6.5, concentrating under reduced pressure, lyophilization with hydrochloric acid, obtains Cortex Phellodendri alkaloid Extract, standby；Take drug component A to be dissolved in the ethanol that volumetric concentration is 5% and make the drug component A that mass concentration is 7% Solution, is sequentially added into medical polypropylene acid sodium, sodium carboxymethyl cellulose, pharmagel, tragacanth, water mix homogeneously, makes patch Agent moulding material I；Separately take Cortex Phellodendri alkaloid extract and be dissolved in the ethanol that volumetric concentration is 8% that to make mass concentration be 5% Cortex Phellodendri alkaloid solution, sequentially adds volatile oil, carbomer, water are sufficiently mixed uniformly, make patch moulding material II；Will patch Agent moulding material II is mixed homogeneously and the most swelling with the quality ratio of 3.2:1 with patch moulding material I, makes patch, must control Treat the Chinese herbs paste of infantile pneumonia；
The moulding material I of described patch is by following mass percent: drug component solution A 8.5%-13.5%, Medical polypropylene acid sodium 11%-16%, sodium carboxymethyl cellulose 2%-5.1%, pharmagel 2.2%-5.1%, tragacanth 1.3%-2.1%, surplus is water, and total amount 100% forms；Patch moulding material II is by following mass percent: Cortex Phellodendri Alkaloid solution 3%-5%, volatile oil 1%-5%, carbomer 19.3%-27.6%, surplus is water, and total amount 100% forms.
Compatibility of the present invention is reasonable, determined curative effect, and life-time service side effect is little, and water content is high, without allergic phenomena, processing technology Simple, materials environmental protection, is the innovation on the Chinese herbs paste for the treatment of infantile pneumonia.
Detailed description of the invention:
Below in conjunction with embodiment, the detailed description of the invention of the present invention is described in further detail.
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following weight meter: Cortex Magnoliae Officinalis 71g, 71g Radix Ophiopogonis, Semen Lepidii Sub-71g, Bulbus Fritillariae Thunbergii 71g, Flos Farfarae 71g, Caulis Lonicerae 71g, Herba Solani Nigri 71g, Rhizoma Zingiberis 71g, Cortex Phellodendri 91g, Flos Caryophylli 61g, Radix Bupleuri 71g, Herba Houttuyniae 81g, Herba Menthae 61g, wherein, mix Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis, extracts with supercritical fluid Follow the example of extraction volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixing, pulverize, put into supercritical extraction Fetching is put, and extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, extraction time 120min, CO2Flow 17L/ H, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Radix Ophiopogonis Rattan, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A weight The ethanol that volumetric concentration is 70%-95% of amount 10-16 times amount, extracts 2 times with flash extracter, each 1-3min, filters, and closes And filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, lyophilization, obtains drug component A, standby；Take Cortex Phellodendri medical material powder Broken, the ethanol solution that pH2.5 volumetric concentration is 50% 25 DEG C adding Cortex Phellodendri medical material weight 15 times soaks 8h, 95 DEG C of reflux, extract, 3h, filters, and filtrate reduced in volume to proportion is 1.08-1.15, storng-acid cation exchange resin on concentrated solution, with containing 1mol/L The volumetric concentration of ammonia be 70% ethanol solution carry out eluting, eluent is adjusted to pH6.5 with hydrochloric acid, concentrating under reduced pressure, freezing dry Dry, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A to be dissolved in and mass concentration made by the ethanol that volumetric concentration is 5% be The drug component solution A of 7%, be sequentially added into medical polypropylene acid sodium, sodium carboxymethyl cellulose, pharmagel, tragacanth, water mix Close uniformly, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract to be dissolved in the ethanol that volumetric concentration is 8% and make matter Amount concentration is the Cortex Phellodendri alkaloid solution of 5%, sequentially adds volatile oil, carbomer, water are sufficiently mixed uniformly, make patch one-tenth Shaped material II；Patch moulding material II is mixed homogeneously and the most swelling with the quality ratio of 3.2:1 with patch moulding material I, system Become patch, the Chinese herbs paste of infantile pneumonia must be treated；
The moulding material I of described patch is by following mass percent: drug component solution A 8.5%, medicinal poly-third Olefin(e) acid sodium 11%, sodium carboxymethyl cellulose 2%, pharmagel 2.2%, tragacanth 1.3%, surplus is water, total amount 100% group Become；Patch moulding material II is by following mass percent: Cortex Phellodendri alkaloid solution 3%, volatile oil 1%, carbomer 19.3%, surplus is water, and total amount 100% forms.
Embodiment 2
The present invention in the specific implementation, can be made up of the material medicine of following weight meter: Cortex Magnoliae Officinalis 75g, 75g Radix Ophiopogonis, Semen Lepidii Sub-75g, Bulbus Fritillariae Thunbergii 75g, Flos Farfarae 75g, Caulis Lonicerae 75g, Herba Solani Nigri 75g, Rhizoma Zingiberis 75g, Cortex Phellodendri 95g, Flos Caryophylli 65g, Radix Bupleuri 75g, Herba Houttuyniae 85g, Herba Menthae 65g, wherein, mix Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis, extracts with supercritical fluid Follow the example of extraction volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixing, pulverize, put into supercritical extraction Fetching is put, and extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, extraction time 120min, CO2Flow 17L/ H, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Radix Ophiopogonis Rattan, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A weight The ethanol that volumetric concentration is 70%-95% of amount 10-16 times amount, extracts 2 times with flash extracter, each 1-3min, filters, and closes And filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, lyophilization, obtains drug component A, standby；Take Cortex Phellodendri medical material powder Broken, the ethanol solution that pH2.5 volumetric concentration is 50% 25 DEG C adding Cortex Phellodendri medical material weight 15 times soaks 8h, 95 DEG C of reflux, extract, 3h, filters, and filtrate reduced in volume to proportion is 1.08-1.15, storng-acid cation exchange resin on concentrated solution, with containing 1mol/L The volumetric concentration of ammonia be 70% ethanol solution carry out eluting, eluent is adjusted to pH6.5 with hydrochloric acid, concentrating under reduced pressure, freezing dry Dry, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A to be dissolved in and mass concentration made by the ethanol that volumetric concentration is 5% be The drug component solution A of 7%, be sequentially added into medical polypropylene acid sodium, sodium carboxymethyl cellulose, pharmagel, tragacanth, water mix Close uniformly, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract to be dissolved in the ethanol that volumetric concentration is 8% and make matter Amount concentration is the Cortex Phellodendri alkaloid solution of 5%, sequentially adds volatile oil, carbomer, water are sufficiently mixed uniformly, make patch one-tenth Shaped material II；Patch moulding material II is mixed homogeneously and the most swelling with the quality ratio of 3.2:1 with patch moulding material I, system Become patch, the Chinese herbs paste of infantile pneumonia must be treated；
The moulding material I of described patch is by following mass percent: drug component solution A 11.5%, medicinal poly- Sodium acrylate 14%, sodium carboxymethyl cellulose 3.5%, pharmagel 3.5%, tragacanth 1.6%, surplus is water, total amount 100% Composition；Patch moulding material II is by following mass percent: Cortex Phellodendri alkaloid solution 4%, volatile oil 3%, carbomer 23.5%, surplus is water, and total amount 100% forms.
Embodiment 3
The present invention in the specific implementation, can be made up of the material medicine of following weight meter: Cortex Magnoliae Officinalis 79g, 79g Radix Ophiopogonis, Semen Lepidii Sub-79g, Bulbus Fritillariae Thunbergii 79g, Flos Farfarae 79g, Caulis Lonicerae 79g, Herba Solani Nigri 79g, Rhizoma Zingiberis 79g, Cortex Phellodendri 99g, Flos Caryophylli 69g, Radix Bupleuri 79g, Herba Houttuyniae 89g, Herba Menthae 69g, wherein, mix Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis, extracts with supercritical fluid Follow the example of extraction volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixing, pulverize, put into supercritical extraction Fetching is put, and extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, extraction time 120min, CO2Flow 17L/ H, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Radix Ophiopogonis Rattan, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A weight The ethanol that volumetric concentration is 70%-95% of amount 10-16 times amount, extracts 2 times with flash extracter, each 1-3min, filters, and closes And filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, lyophilization, obtains drug component A, standby；Take Cortex Phellodendri medical material powder Broken, the ethanol solution that pH2.5 volumetric concentration is 50% 25 DEG C adding Cortex Phellodendri medical material weight 15 times soaks 8h, 95 DEG C of reflux, extract, 3h, filters, and filtrate reduced in volume to proportion is 1.08-1.15, storng-acid cation exchange resin on concentrated solution, with containing 1mol/L The volumetric concentration of ammonia be 70% ethanol solution carry out eluting, eluent is adjusted to pH6.5 with hydrochloric acid, concentrating under reduced pressure, freezing dry Dry, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A to be dissolved in and mass concentration made by the ethanol that volumetric concentration is 5% be The drug component solution A of 7%, be sequentially added into medical polypropylene acid sodium, sodium carboxymethyl cellulose, pharmagel, tragacanth, water mix Close uniformly, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract to be dissolved in the ethanol that volumetric concentration is 8% and make matter Amount concentration is the Cortex Phellodendri alkaloid solution of 5%, sequentially adds volatile oil, carbomer, water are sufficiently mixed uniformly, make patch one-tenth Shaped material II；Patch moulding material II is mixed homogeneously and the most swelling with the quality ratio of 3.2:1 with patch moulding material I, system Become patch, the Chinese herbs paste of infantile pneumonia must be treated；
The moulding material I of described patch is by following mass percent: drug component solution A 13.5%, medicinal poly- Sodium acrylate 16%, sodium carboxymethyl cellulose 5.1%, pharmagel 5.1%, tragacanth 2.1%, surplus is water, total amount 100% Composition；Patch moulding material II is by following mass percent: Cortex Phellodendri alkaloid solution 5%, volatile oil 5%, carbomer 27.6%, surplus is water, and total amount 100% forms.
Embodiment 4
The present invention in the specific implementation, can be made up of the material medicine of following weight meter: Cortex Magnoliae Officinalis 78g, 72g Radix Ophiopogonis, Semen Lepidii Sub-76g, Bulbus Fritillariae Thunbergii 73g, Flos Farfarae 77g, Caulis Lonicerae 79g, Herba Solani Nigri 71g, Rhizoma Zingiberis 72g, Cortex Phellodendri 98g, Flos Caryophylli 66g, Radix Bupleuri 76g, Herba Houttuyniae 87g, Herba Menthae 63g, wherein, mix Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis, extracts with supercritical fluid Follow the example of extraction volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixing, pulverize, put into supercritical extraction Fetching is put, and extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, extraction time 120min, CO2Flow 17L/ H, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Radix Ophiopogonis Rattan, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A weight The ethanol that volumetric concentration is 70%-95% of amount 10-16 times amount, extracts 2 times with flash extracter, each 1-3min, filters, and closes And filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, lyophilization, obtains drug component A, standby；Take Cortex Phellodendri medical material powder Broken, the ethanol solution that pH2.5 volumetric concentration is 50% 25 DEG C adding Cortex Phellodendri medical material weight 15 times soaks 8h, 95 DEG C of reflux, extract, 3h, filters, and filtrate reduced in volume to proportion is 1.08-1.15, storng-acid cation exchange resin on concentrated solution, with containing 1mol/L The volumetric concentration of ammonia be 70% ethanol solution carry out eluting, eluent is adjusted to pH6.5 with hydrochloric acid, concentrating under reduced pressure, freezing dry Dry, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A to be dissolved in and mass concentration made by the ethanol that volumetric concentration is 5% be The drug component solution A of 7%, be sequentially added into medical polypropylene acid sodium, sodium carboxymethyl cellulose, pharmagel, tragacanth, water mix Close uniformly, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract to be dissolved in the ethanol that volumetric concentration is 8% and make matter Amount concentration is the Cortex Phellodendri alkaloid solution of 5%, sequentially adds volatile oil, carbomer, water are sufficiently mixed uniformly, make patch one-tenth Shaped material II；Patch moulding material II is mixed homogeneously and the most swelling with the quality ratio of 3.2:1 with patch moulding material I, system Become patch, the Chinese herbs paste of infantile pneumonia must be treated；
The moulding material I of described patch is by following mass percent: drug component solution A 8.7%, medicinal poly-third Olefin(e) acid sodium 15%, sodium carboxymethyl cellulose 2.2%, pharmagel 5.0%, tragacanth 1.4%, surplus is water, total amount 100% group Become；Patch moulding material II is by following mass percent: Cortex Phellodendri alkaloid solution 3%, volatile oil 4.8%, carbomer 19.5%, surplus is water, and total amount 100% forms.
One, Chinese medicine patch of the present invention has carried out series of experiments according to country's new drug approval regulation, all achieves satisfied skill Art effect, related experiment data is as follows:
1, acute toxicity test:
Take Cavia porcellus 60, random packet, depilation, the experiment of external Chinese herbs paste of the present invention, successive administration 15 days；Result: globefish Pindone is whole and none animal dead of big small dose group of damaged skin, each activity organizing Cavia porcellus, defecation, and mental status etc. is the most just Often, damaged skin NIP, oozing of blood etc. react, and also do not find obvious whole body toxicity, Chinese medicine prepared by the present invention is described Patch application safety.
2, Skin Irritation Test:
Chinese herbs paste prepared by the present invention to Cavia porcellus intact skin without obvious irritation；To damaged skin zest relatively Little, there is not erythema, infection or the skin irritation phenomenon such as redness, edema in local.
3, hypersensitive test:
Taking Cavia porcellus 50, male and female half and half, random packet is tested；Result: use aqueous Chinese medicine patch prepared by the present invention After agent, the hair color of Cavia porcellus, the mental status etc. does not has abnormal phenomena, illustrates that Chinese herbs paste prepared by the present invention does not produce allergy existing As.
4, long term toxicity test:
Cavia porcellus continuous use 90 days；Result: Chinese herbs paste of the present invention is to the hair of Cavia porcellus, behavior, defecation, body weight, dirty The indexs such as the amount of thinking highly of, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect.Histological examination shows, medication 90 days and stopping After medicine 2 weeks, each internal organs of Cavia porcellus are all without obvious Histological change.Cavia porcellus performance the most without exception is respectively organized, OK during medication and after drug withdrawal For vivaciously, ingesting normal, defecation is without exception.Illustrate that aqueous Chinese herbs paste prepared by the present invention is without long term toxicity, application safety.
Two, in order to prove that Chinese medicine patch of the present invention can be effective to treat infantile pneumonia, and there is effective effect, carry out Clinical verification experiment, specific as follows:
1, case clinic selection standard:
" the Chinese medical disease Standardization of diagnosis and curative effect " issued according to traditional chinese medical science administration of country, is randomly divided into treatment group and compares Group, treatment group 80 example, male 36 examples, female 44 example；Matched group 80 example, male 35 examples, female 45 example；Two groups of ages all in 2-10 year, in year Age, course of disease aspect there was no significant difference (P ＞ 0.05).
2, therapeutic scheme: matched group uses routine clinical treatment.Treatment group: on the basis for the treatment of of control group, at bilateral Fei shu, region below the heart, Dingchuan, Danzhong acupuncture point lose money in a business invention aqueous Chinese medicine patch, paste 24h, every day 1 time every time, add up curative effect after 7 days.
3, criterion of therapeutical effect:
Clinical recovery: body temperature, cough, expectoration and pulmonary's sound recover normal, other clinical symptom disappearance；
Effective: temperature recovery is normal, cough, expectoration and pulmonary's sound significantly take a turn for the better (or level before acute attack)；
Effective: body temperature, cough, expectoration and pulmonary's sound take a favorable turn, other transference cures or improvement, but degree is not as good as effective；
Invalid: body temperature, cough, expectoration pulmonary sound are without changing or increasing the weight of, and other clinical symptoms are many without improving or increasing the weight of.
4, clinical efficacy statistics:
Table 1 general curative effect compares
* P ＜ 0.05 is compared with matched group
Table 2 treatment after cardinal symptom improve the time compare (Unit: sky)
* P ＜ 0.05 is compared with matched group
From data above, the effective percentage for the treatment of group apparently higher than matched group, and fever time, cough and expectoration disappear time Between, the index treatment group such as pulmonary's sound improvement time be superior to matched group.
5, conclusion
Clinical experiment shows, Chinese medicine patch of the present invention uses safety, does not occurs local skin pruritus, redness, allergy in test Etc. phenomenon, the total effective rate of children Streptococcus is reached 96.25%, substantially reduce treatment time with combining of conventional therapy means Improve therapeutic effect, be the innovation on the Chinese herbs paste for the treatment of infantile pneumonia, there is the clinical meaning of reality and push away widely Wide using value.

Claims (5)

1. the Chinese herbs paste treating infantile pneumonia, it is characterised in that be made up of the material medicine of following weight meter: Cortex Magnoliae Officinalis 70-80g, 70-80g Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae) 70-80g, Bulbus Fritillariae Thunbergii 70-80g, Flos Farfarae 70-80g, Caulis Lonicerae 70-80g, Herba Solani Nigri 70- 80g, Rhizoma Zingiberis 70-80g, Cortex Phellodendri 90-100g, Flos Caryophylli 60-70g, Radix Bupleuri 70-80g, Herba Houttuyniae 80-90g, Herba Menthae 60-70g, its In, Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis are mixed, extracts volatile oil with supercritical fluid extraction, specifically walk Suddenly it is: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixing, pulverize, put into supercritical extraction unit, extract according to following condition Take: extraction temperature 38 DEG C, extracting pressure 20MPa, extraction time 120min, CO2Flow 17L/h, extraction gained volatile oil is standby, Gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A are blended in one Rise, add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, the volumetric concentration of medicinal residues A weight 10-16 times amount For the ethanol of 70%-95%, extracting 2 times with flash extracter, each 1-3min, filter, merging filtrate, 50 DEG C are evaporated to Proportion is 1.06-1.12, lyophilization, obtains drug component A, standby；Take Cortex Phellodendri pulverizing medicinal materials, add Cortex Phellodendri medical material weight 15 times The ethanol solution that pH2.5 volumetric concentration is 50% 25 DEG C soak 8h, 95 DEG C of reflux, extract, 3h, filter, filtrate reduced in volume is extremely Proportion is 1.08-1.15, storng-acid cation exchange resin on concentrated solution, is 70% with the volumetric concentration containing 1mol/L ammonia Ethanol solution carries out eluting, and eluent is adjusted to pH6.5, concentrating under reduced pressure, lyophilization with hydrochloric acid, obtains Cortex Phellodendri alkaloid extract, Standby；Take drug component A to be dissolved in the ethanol that volumetric concentration is 5% and make the drug component solution A that mass concentration is 7%, depend on Secondary addition medical polypropylene acid sodium, sodium carboxymethyl cellulose, pharmagel, tragacanth, water mix homogeneously, make patch forming material Material I；Separately take Cortex Phellodendri alkaloid extract and be dissolved in the ethanol that volumetric concentration is 8% that to make Cortex Phellodendri that mass concentration is 5% biological Aqueous slkali, sequentially adds volatile oil, carbomer, water are sufficiently mixed uniformly, make patch moulding material II；By patch forming material Material II is mixed homogeneously and the most swelling with the quality ratio of 3.2:1 with patch moulding material I, makes patch, obtains treatment Lungs of Children Scorching Chinese herbs paste；
The moulding material I of described patch is by following mass percent: drug component solution A 8.5%-13.5%, medicinal Sodium polyacrylate 11%-16%, sodium carboxymethyl cellulose 2%-5.1%, pharmagel 2.2%-5.1%, tragacanth 1.3%- 2.1%, surplus is water, and total amount 100% forms；Patch moulding material II is by following mass percent: Cortex Phellodendri alkaloid Solution 3%-5%, volatile oil 1%-5%, carbomer 19.3%-27.6%, surplus is water, and total amount 100% forms.
The Chinese herbs paste for the treatment of infantile pneumonia the most according to claim 1, it is characterised in that by the raw material of following weight meter Medicine is made: Cortex Magnoliae Officinalis 71g, 71g Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae) 71g, Bulbus Fritillariae Thunbergii 71g, Flos Farfarae 71g, Caulis Lonicerae 71g, Herba Solani Nigri 71g, Rhizoma Zingiberis 71g, Cortex Phellodendri 91g, Flos Caryophylli 61g, Radix Bupleuri 71g, Herba Houttuyniae 81g, Herba Menthae 61g, wherein, by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, do Rhizoma Zingiberis Recens mixes, with supercritical fluid extraction extract volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixes, and pulverizes, and puts into supercritical extraction unit, extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, Extraction time 120min, CO2Flow 17L/h, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, money Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, the ethanol that volumetric concentration is 70%-95% of medicinal residues A weight 10-16 times amount, carry with flash extracter Taking 2 times, each 1-3min, filter, merging filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, and lyophilization obtains medicine Component A, standby；Take Cortex Phellodendri pulverizing medicinal materials, add the ethanol solution that pH2.5 volumetric concentration is 50% of Cortex Phellodendri medical material weight 15 times 25 DEG C are soaked 8h, 95 DEG C of reflux, extract, 3h, filter, and filtrate reduced in volume to proportion is 1.08-1.15, highly acid sun on concentrated solution Ion exchange resin, carries out eluting with the ethanol solution that volumetric concentration is 70% containing 1mol/L ammonia, and eluent is adjusted with hydrochloric acid To pH6.5, concentrating under reduced pressure, lyophilization, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A and be dissolved in volumetric concentration and be The ethanol of 5% is made the drug component solution A that mass concentration is 7%, is sequentially added into medical polypropylene acid sodium, carboxymethyl cellulose Element sodium, pharmagel, tragacanth, water mix homogeneously, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract and be dissolved in body Volume concentrations be 8% ethanol in make the Cortex Phellodendri alkaloid solution that mass concentration is 5%, sequentially add volatile oil, carbomer, Water is sufficiently mixed uniformly, makes patch moulding material II；By patch moulding material II and patch moulding material I with the matter of 3.2:1 Measure than mix homogeneously the most swelling, make patch, the Chinese herbs paste of infantile pneumonia must be treated；
The moulding material I of described patch is by following mass percent: the acid of drug component solution A 8.5%, medical polypropylene Sodium 11%, sodium carboxymethyl cellulose 2%, pharmagel 2.2%, tragacanth 1.3%, surplus is water, and total amount 100% forms；Patch Agent moulding material II is by following mass percent: Cortex Phellodendri alkaloid solution 3%, volatile oil 1%, carbomer 19.3%, Surplus is water, and total amount 100% forms.
The Chinese herbs paste for the treatment of infantile pneumonia the most according to claim 1, it is characterised in that by the raw material of following weight meter Medicine is made: Cortex Magnoliae Officinalis 75g, 75g Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae) 75g, Bulbus Fritillariae Thunbergii 75g, Flos Farfarae 75g, Caulis Lonicerae 75g, Herba Solani Nigri 75g, Rhizoma Zingiberis 75g, Cortex Phellodendri 95g, Flos Caryophylli 65g, Radix Bupleuri 75g, Herba Houttuyniae 85g, Herba Menthae 65g, wherein, by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, do Rhizoma Zingiberis Recens mixes, with supercritical fluid extraction extract volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixes, and pulverizes, and puts into supercritical extraction unit, extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, Extraction time 120min, CO2Flow 17L/h, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, money Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, the ethanol that volumetric concentration is 70%-95% of medicinal residues A weight 10-16 times amount, carry with flash extracter Taking 2 times, each 1-3min, filter, merging filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, and lyophilization obtains medicine Component A, standby；Take Cortex Phellodendri pulverizing medicinal materials, add the ethanol solution that pH2.5 volumetric concentration is 50% of Cortex Phellodendri medical material weight 15 times 25 DEG C are soaked 8h, 95 DEG C of reflux, extract, 3h, filter, and filtrate reduced in volume to proportion is 1.08-1.15, highly acid sun on concentrated solution Ion exchange resin, carries out eluting with the ethanol solution that volumetric concentration is 70% containing 1mol/L ammonia, and eluent is adjusted with hydrochloric acid To pH6.5, concentrating under reduced pressure, lyophilization, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A and be dissolved in volumetric concentration and be The ethanol of 5% is made the drug component solution A that mass concentration is 7%, is sequentially added into medical polypropylene acid sodium, carboxymethyl cellulose Element sodium, pharmagel, tragacanth, water mix homogeneously, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract and be dissolved in body Volume concentrations be 8% ethanol in make the Cortex Phellodendri alkaloid solution that mass concentration is 5%, sequentially add volatile oil, carbomer, Water is sufficiently mixed uniformly, makes patch moulding material II；By patch moulding material II and patch moulding material I with the matter of 3.2:1 Measure than mix homogeneously the most swelling, make patch, the Chinese herbs paste of infantile pneumonia must be treated；
The moulding material I of described patch is by following mass percent: drug component solution A 11.5%, medical polypropylene Acid sodium 14%, sodium carboxymethyl cellulose 3.5%, pharmagel 3.5%, tragacanth 1.6%, surplus is water, total amount 100% group Become；Patch moulding material II is by following mass percent: Cortex Phellodendri alkaloid solution 4%, volatile oil 3%, carbomer 23.5%, surplus is water, and total amount 100% forms.
The Chinese herbs paste for the treatment of infantile pneumonia the most according to claim 1, it is characterised in that by the raw material of following weight meter Medicine is made: Cortex Magnoliae Officinalis 79g, 79g Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae) 79g, Bulbus Fritillariae Thunbergii 79g, Flos Farfarae 79g, Caulis Lonicerae 79g, Herba Solani Nigri 79g, Rhizoma Zingiberis 79g, Cortex Phellodendri 99g, Flos Caryophylli 69g, Radix Bupleuri 79g, Herba Houttuyniae 89g, Herba Menthae 69g, wherein, by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, do Rhizoma Zingiberis Recens mixes, with supercritical fluid extraction extract volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixes, and pulverizes, and puts into supercritical extraction unit, extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, Extraction time 120min, CO2Flow 17L/h, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, money Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, the ethanol that volumetric concentration is 70%-95% of medicinal residues A weight 10-16 times amount, carry with flash extracter Taking 2 times, each 1-3min, filter, merging filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, and lyophilization obtains medicine Component A, standby；Take Cortex Phellodendri pulverizing medicinal materials, add the ethanol solution that pH2.5 volumetric concentration is 50% of Cortex Phellodendri medical material weight 15 times 25 DEG C are soaked 8h, 95 DEG C of reflux, extract, 3h, filter, and filtrate reduced in volume to proportion is 1.08-1.15, highly acid sun on concentrated solution Ion exchange resin, carries out eluting with the ethanol solution that volumetric concentration is 70% containing 1mol/L ammonia, and eluent is adjusted with hydrochloric acid To pH6.5, concentrating under reduced pressure, lyophilization, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A and be dissolved in volumetric concentration and be The ethanol of 5% is made the drug component solution A that mass concentration is 7%, is sequentially added into medical polypropylene acid sodium, carboxymethyl cellulose Element sodium, pharmagel, tragacanth, water mix homogeneously, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract and be dissolved in body Volume concentrations be 8% ethanol in make the Cortex Phellodendri alkaloid solution that mass concentration is 5%, sequentially add volatile oil, carbomer, Water is sufficiently mixed uniformly, makes patch moulding material II；By patch moulding material II and patch moulding material I with the matter of 3.2:1 Measure than mix homogeneously the most swelling, make patch, the Chinese herbs paste of infantile pneumonia must be treated；The moulding material of described patch I by following mass percent: drug component solution A 13.5%, medical polypropylene acid sodium 16%, sodium carboxymethyl cellulose 5.1%, pharmagel 5.1%, tragacanth 2.1%, surplus is water, and total amount 100% forms；Patch moulding material II is by following Mass percent: Cortex Phellodendri alkaloid solution 5%, volatile oil 5%, carbomer 27.6%, surplus is water, total amount 100% group Become.
The Chinese herbs paste for the treatment of infantile pneumonia the most according to claim 1, it is characterised in that by the raw material of following weight meter Medicine is made: Cortex Magnoliae Officinalis 78g, 72g Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae) 76g, Bulbus Fritillariae Thunbergii 73g, Flos Farfarae 77g, Caulis Lonicerae 79g, Herba Solani Nigri 71g, Rhizoma Zingiberis 72g, Cortex Phellodendri 98g, Flos Caryophylli 66g, Radix Bupleuri 76g, Herba Houttuyniae 87g, Herba Menthae 63g, wherein, by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, do Rhizoma Zingiberis Recens mixes, with supercritical fluid extraction extract volatile oil, concretely comprise the following steps: by Flos Caryophylli, Radix Bupleuri, Herba Houttuyniae, Herba Menthae, Rhizoma Zingiberis mixes, and pulverizes, and puts into supercritical extraction unit, extracts according to following condition: extraction temperature 38 DEG C, extracting pressure 20MPa, Extraction time 120min, CO2Flow 17L/h, extraction gained volatile oil is standby, and gained medicinal residues A weighs, standby；Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, medicinal residues A mix, and add Cortex Magnoliae Officinalis, Radix Ophiopogonis, Semen Lepidii (Semen Descurainiae), Bulbus Fritillariae Thunbergii, money Flos Farfarae, Caulis Lonicerae, Herba Solani Nigri, the ethanol that volumetric concentration is 70%-95% of medicinal residues A weight 10-16 times amount, carry with flash extracter Taking 2 times, each 1-3min, filter, merging filtrate, 50 DEG C are evaporated to proportion is 1.06-1.12, and lyophilization obtains medicine Component A, standby；Take Cortex Phellodendri pulverizing medicinal materials, add the ethanol solution that pH2.5 volumetric concentration is 50% of Cortex Phellodendri medical material weight 15 times 25 DEG C are soaked 8h, 95 DEG C of reflux, extract, 3h, filter, and filtrate reduced in volume to proportion is 1.08-1.15, highly acid sun on concentrated solution Ion exchange resin, carries out eluting with the ethanol solution that volumetric concentration is 70% containing 1mol/L ammonia, and eluent is adjusted with hydrochloric acid To pH6.5, concentrating under reduced pressure, lyophilization, obtain Cortex Phellodendri alkaloid extract, standby；Take drug component A and be dissolved in volumetric concentration and be The ethanol of 5% is made the drug component solution A that mass concentration is 7%, is sequentially added into medical polypropylene acid sodium, carboxymethyl cellulose Element sodium, pharmagel, tragacanth, water mix homogeneously, make patch moulding material I；Separately take Cortex Phellodendri alkaloid extract and be dissolved in body Volume concentrations be 8% ethanol in make the Cortex Phellodendri alkaloid solution that mass concentration is 5%, sequentially add volatile oil, carbomer, Water is sufficiently mixed uniformly, makes patch moulding material II；By patch moulding material II and patch moulding material I with the matter of 3.2:1 Measure than mix homogeneously the most swelling, make patch, the Chinese herbs paste of infantile pneumonia must be treated；
The moulding material I of described patch is by following mass percent: the acid of drug component solution A 8.7%, medical polypropylene Sodium 15%, sodium carboxymethyl cellulose 2.2%, pharmagel 5.0%, tragacanth 1.4%, surplus is water, and total amount 100% forms； Patch moulding material II is by following mass percent: Cortex Phellodendri alkaloid solution 3%, volatile oil 4.8%, carbomer 19.5%, surplus is water, and total amount 100% forms.
CN201610832926.6A 2016-09-20 2016-09-20 A kind of Chinese herbs paste treating infantile pneumonia Pending CN106166290A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102846842A (en) * 2012-10-16 2013-01-02 河南中医学院 Topical gel for treating rheumatic arthritis
CN105125984A (en) * 2015-08-21 2015-12-09 郑州市儿童医院 Water-based external herbal plaster for treating infantile cough

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102846842A (en) * 2012-10-16 2013-01-02 河南中医学院 Topical gel for treating rheumatic arthritis
CN105125984A (en) * 2015-08-21 2015-12-09 郑州市儿童医院 Water-based external herbal plaster for treating infantile cough

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
鞠燕鹏: "中西医结合治疗儿童支原体肺炎", 《山西中医》 *

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