CN103071134A - External preparation for treating rheumatic arthrodynia and traumatic pain and swelling and preparation method thereof - Google Patents
External preparation for treating rheumatic arthrodynia and traumatic pain and swelling and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an external medicine, in particular to an external preparation for treating rheumatic arthrodynia and traumatic pain and swelling. The preparation is characterized in that every 1000ml external preparation is prepared from the following principal raw materials by weight: 26-46 g of gnetum montanum, 10-30 g of pine pen, 5-25 g of fructus schizandrae, 5-25 g of gaultheria yunnanensis, 14-34 g of radix zanthoxyli, 5-20 g of safflower, 5-20 g of camphanone, 5-20 g of elecampane inula root, 5-25 g of menispermum dauricum, 5-25 g of cochinchina raspberry root or leaf, 5-25 g of rhizoma zingiberis and 5-25 g of menthol. The preparation can promote blood circulation, dissipate blood stasis, disperse the swelling, relieve the pain, expel wind and remove dampness, is obvious in treatment effect, quick in effect and safe, and has no toxic or side effects; and the variety of the traditional Chinese medicine for treating the rheumatic arthrodynia, arthritis, the traumatic pain and swelling, and acute sprain and contusion is enriched.
Description
Technical field
The present invention relates to a kind of Chinese medicine for outer use, particularly a kind of external preparation medicine for the treatment of Fengshi Guanjie pain and treating swelling and pain by traumatic injury.
Background technology
Fengshi Guanjie pain is because blood circulation is obstructed causes muscle or organize needed nutrition to carry by blood circulation, and muscle lacks nutrition and accelerated ageing becomes stiff, the chronic pain that causes patient joint and soft tissue on every side thereof to produce.According to " China's rheumatic four diseases Survey on epidemiological features ", rheumatism is l 4% at the general population sickness rate of China, and special trade (weaving, steel machinery, chemical industry, mine oil, harbour, army) is up to 23.1%; The main ill crowd of rheumatic four diseases is in 40-60 year; Present China estimates at 1.82 hundred million people and suffers from rheumatism, and the patient accounts for 9,464 ten thousand people more than 40 years old.Wind-warm syndrome causes handicapped in daily life and work to the patient, and disability rate is high, and patient's physiology, psychology is caused very big impact, forms greatly burden for society.
The generation for the treatment of swelling and pain by traumatic injury bruise not only injures limbs but also injure QI and blood, stagnation of QI leukemia phenomenon occurs, because crazy blood is the not broken and interior damage person of skin, mostly is blood circulating out of vessels and gathers in a place, can not dissipate for the moment in vivo and the flesh table occurs swelling and ache livid purple, and painful area is fixed.Chinese medicine is thought stagnation of QI and blood may bring about pain, no matter the stagnation of QI or leukemia are all obstructed, the cause of disease of this explanation osteopatia sprain is due to the external force, and pathogenesis is stagnation of QI leukemia.Rheumatic arthralgia and bruise are commonly encountered diseases, frequently-occurring disease, and it has a strong impact on and produces and life.Although the Chinese medicine preparation of many treatment traumatic injury, rheumatic bone carbuncle is arranged at present clinically, such as Chinese patent: Wound dispelling swell dispersing tincture and preparation method thereof, application number 200510066151.8, publication number CN 1686414A, applicant: Haiwang Jinxiang Chinese Medicine Pharmaceutical Co., Ltd., Fuzhou City, address: Jin, Fuzhou, Fujian Province peace Qu Kuiqi, inventor: Xu Yanhe.Summary: a kind of Wound dispelling swell dispersing acid anhydride and preparation method thereof, 56-84 parts of Mentholums, Borneolum Syntheticum 48-72 part, Radix Zanthoxyli 48-72 part, Caulis et folium stauntoniae 36-54 part, Herba Glechomae 24-36 part, Fructus Gardeniae 24-36 part, join beans grass 24-36 part, Camphora 24-36 part, Radix Aconiti Kusnezoffii 16-24 part, vegetables art 14-22 part, Ramulus Cinnamomi 14-22 part, Flos Carthami 12-18 part, Radix Clematidis 12-18 part, Herba Droserae Lunatae 12-18 part, Caulis Piperis Kadsurae 12-18 part, CHUANSHAO l0-14 part, Radix Wikstroemae l0-14 part, Rhizoma Arisaematis l0-14 part, white positive l0-14 part, Sanguis Draxonis 2-4 part is made, be used for the treatment of traumatic injury, acute jerk contused wound, crazy hematoma pain, detumescence, pain relieving is fast, curative effect is high, and is easy to use.Chinese patent and for example: a kind of Chinese medicinal ointment compositions, its preparation method, its cataplasma and preparation method thereof, application number 200510075043.7, publication number CN 1698815A, applicant: Huahong Pharmaceutical Co., Ltd., Guangxi, address: No. 74, Hongguang Road ,Liuzhou City ,Guangxi Zhuang Autonomousnationality District, inventor: Wei Feiyan, summary: a kind of Chinese medicinal ointment compositions, its preparation method, its cataplasma and preparation method thereof, comprise active component, penetration enhancer and substrate.Described active component take Radix Saposhnikoviae, Herba Schizonepetae, Herba Asari, Radix Achyranthis Bidentatae, CHUANSHAO, Radix Cynanchi Paniculati, vegetables art, DALUOSAN, Radix Ardisiae punctatae, Radix Zanthoxyli, rhizoma sparganic, Ramulus Cinnamomi, in vain just, Radix seu Caulis Parabarii, the Radix Aucklandiae, Caulis Fibraureae, Cortex Acanthopancis, Fructus Gardeniae and Lignum Aquilariae Resinatum extract with oozing the method for spattering as raw material, the concentrated extractum that forms is mixed and made into active component with extractum and Camphora, Mentholum again.The preparation method that this invention also relates to this Chinese medicinal ointment compositions with and cataplasma and preparation method thereof.Cataplasma can be used for treating anemofrigid-damp arthralgia, scapulohumeral periarthritis, acute jerk contused wound, innominate toxic swelling, parotid gland swelling and pain and has advantage evident in efficacy, that act on rapidly, have no side effect.For another example Chinese patent: a kind of external-use tincture medicine for the treatment of rheumatic arthralgia and acute jerk contused wound disease and preparation method thereof, application number: 200810073697.X, publication number CN 101336993A, applicant: Yuan An Tang Pharmaceutical Co., Ltd., Guangxi, address: Zhong Sha town, Guiping City, Guangxi Zhuang Autonomous Region, inventor: Mo Zhaoqin, summary: a kind of external acid anhydride agent medicine for the treatment of rheumatic arthralgia and acute jerk contused wound disease is characterized in that the required primary raw material of tincture dose medicament of whenever making 1000ml is by weight ratio: Radix Ardisiae Crenatae 18～28g; Caulis et Folium piperis 18～28g; Cortex Periplocae 18～28g; Radix Zanthoxyli 18～28g; Herba Sarcandrae 18～28g; Camphora 0.5～0.8g; Rhizoma Polygoni Cuspidati 12～19g; Five tastes rattan 6～10g; Borneolum Syntheticum 0.5～0.8g.This product has that expelling wind and cold, Huoxue San " are crazy, the effect of reducing swelling and alleviating pain, its curative effect and bone-setting liquor are suitable, but its raw material source is wide, be easy to obtain, and the main active that can effectively extract and preserve each ignorant medical material in the prescription, and product is without obvious toxic-side effects, uses safety, convenient, enriched the types of drugs to treatment rheumatic arthralgia and acute jerk contused wound disease.
The external-use tincture medicine of above-mentioned disclosed treatment Fengshi Guanjie pain and treating swelling and pain by traumatic injury respectively has characteristics, but the ingredients that has is complicated, and the crude drug source that has is few, and clinical effectiveness is each has something to recommend him.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, effect rapidly, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, expelling wind and removing dampness, safe without toxic side effect, easy to use be used for the treatment of Fengshi Guanjie pain, arthralgia due to cold,, Chinese medicine composition for the treatment of swelling and pain by traumatic injury, acute jerk contused wound and preparation method thereof.
Technical scheme of the present invention is as follows:
The external preparation for the treatment of Fengshi Guanjie pain and treating swelling and pain by traumatic injury is made the required primary raw material of the external preparation medicine of 1000ml by following weight proportion: Caulis Gneti 26-46g, a pinaster 10-30g, five tastes rattan 5-25g, Caulis et folium gaultheriae yunnanensis 5-25g, Radix Zanthoxyli 14-34g, Flos Carthami 5-20g, Camphora 5-20g, Radix Inulae 5-20g, Caulis menispermi 5-25g, Radix seu Folium Rubi Cochinchinensis 5-25g, Rhizoma Zingiberis 5-25g, lotus brain 5-25g; Described external preparation comprises tincture and spray.
The preparation method of described tincture is:
(1) weighs by weight crude drug: Caulis Gneti, pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis and ginger powder are broken into coarse powder;
(2) the former medicine of step (1) coarse powder according to the percolation under fluid extract and the extractum item, make solvent with volumetric concentration 60-80% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, the about 800ml of liquid that filters at the beginning of the collection preserves;
(3) continue percolation till 12 times of weight of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
(4) get in addition Camphora, Mentholum, add ethanol 50ml and make dissolving, add in the mentioned solution, add ethanol to ormal weight, shake up, left standstill 24 hours, filter, bottling namely gets product.
The described method for preparing spray is:
(1) weighs by weight crude drug: Caulis Gneti, pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis and ginger powder are broken into coarse powder;
(2) the former medicine of step (1) coarse powder according to the percolation under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, the about 800ml of liquid that filters at the beginning of the collection preserves;
(3) continue percolation till 12 times of amounts of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
(4) get in addition Camphora, Mentholum, add propylene glycol 50ml and make dissolving, add in the mentioned solution, and add surfactant tween or the span of 0.1-10 gram, 0.5-1 the flavouring agent of gram adds ethanol to ormal weight, shakes up, and leaves standstill 24 hours, filter, in the spray bottle of packing into, namely get the spray product.
The above pulverizing medicinal materials can adopt the conventional method such as independent pulverizing, co-grinding, dry pulverization process, waterproof pulverization.
Performance and the effect of various medical materials of the present invention are as follows:
Caulis Gneti: be Gnetaceae plant Caulis Gneti Gnetum montanum Markgr. or the dry rattan of Caulis Gneti Parvifolii Gnetum parvifolinm (warb) C.Y. cheng.Nature and flavor and function: bitter, warm, return Liver Channel.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis.Be used for rheumatic ostalgia, soreness of bones and muscles, traumatic injury, venom, usual amounts 6～9 grams.Suitable amount used externally, fresh goods are mashed wine and are transferred, and apply a hot compress to the affected part.1. " Luchuan book on Chinese herbal medicine ": " stem and leaf: reuniting the fractured tendons and bones.Control traumatic injury, the fracture injury of tendon and muscle." 2. " the Guangxi medicine is planted register ": " stem and leaf: synthetism, detumescence, pain relieving.The dispelling the wind and dampness pathogens osteodynia.Root: control the arthroncus of knee." 3. Guangzhou army " Chinese herbal medicine handbook commonly used: " rattan is dispelled wind and removed dampness promoting blood circulation to remove blood stasis.The treating rheumatic lumbago and skelalgia, soreness of bones and muscles, traumatic injury, venom." for oral administration: as to fry in shallow oil soup, 2～3 money (0.5～1 liang of bright person).External: smash and apply or mash wine and fry and apply.
Pinaster pen: be the sprout tip of pinaceae plant Pinus massoniana Lamb Pinus massoniana Lamb..
Five tastes rattan: be the dry Herb of milk wort Radix securidacae Alyxia Levinei Merr.[Latin plant animal mineral name] Securidaca inapfondiculata Hassk. ［ S.tavoyana Wall.ex Benn ］, [another name] Ramulus et Folium Claoxyli, Corium elephatis rattan, rub disappear, five horses are patrolled the city, cicada's wings wood.[nature and flavor] suffering; Bitter; Cool.[effect] expelling wind and removing dampness; Eliminating stasis to stop pain.[curing mainly] traumatic injury; Rheumatic ostalgia; Acute gastroenteritis; Allergic dermatitis.
Caulis et folium gaultheriae yunnanensis: be dry root and the stem of apocynaceae plant muscle rattan Alyxia levinei Merr.Caulis et folium gaultheriae yunnanensis Latin plant animal mineral name: Gaultheriayunnanensis(Franch.) Rehd.[G.CrenulataKurzi; VacciniumyunnanenseFranch.], another name: Herba speranskiae tuberculatae, MANSHANXIANG, Radix scopoliae sinensis, coal.[nature and flavor] suffering, temperature.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": warm in nature, acrid in the mouth is peppery, and is slightly poisonous.2. " Kweiyang medicinal herbs among the people ": suffering, temperature, nontoxic.3. " Yunnan Chinese herbal medicine ": suffering, flat.The effect of Caulis et folium gaultheriae yunnanensis [function cures mainly-] expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Dispelling the wind and dampness pathogens arthralgia, water spreads, traumatic injury, toothache, eczema.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control phlegm-fire, bones and muscles pain, steeping in wine, it is good to use.Its stalk is washed anemofrigid-damp arthralgia, bones and muscles pain, and warm bone is diathermanous, endures washing.2. " Kweiyang medicinal herbs among the people ": dispelling the wind and dampness pathogens arthralgia, traumatic injury.3. " the Guangxi medicine is planted register ": circulation of qi promoting, detumescence, relieving cough and resolving phlegm.Control toothache, impairment caused by overstrain, snakebite, rheumatism, eruptive disease, skin sufferings.4. " Guizhou medical herbs ": expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.5. " Kunming medical herbs commonly used among the people ": active deep.
Radix Zanthoxyli: be rutaceae Radix Zanthoxyli Zanthoxylum nitidum (Roxb.) DC. or Radix Zanthoxyli Zanthoxylum nitidum var, the dry Herb of fastuosum How ex Huang.Another name another name: thread a needle, Da Ye cat branch le, the tiger that goes up a hill, Radix Phytolaccae, Pericarpium Zanthoxyli nature and flavor under Radix Zanthoxyli, red heart Zanthoxylum nitidum (Roxb.) DC, the red le of falling the hook, Radix Zanthoxyli, two-sided pin, Zanthoxylum nitidum (Roxb.) DC, the leaf: bitter, hot, put down; Slightly poisonous.Gui Jing: return liver, stomach warp.Function cures mainly: promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral.Be used for traumatic injury, rheumatic arthralgia, stomachache, toothache that qi depression to blood stasis causes, venom; The burning hot wound of external treatment soup.
Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Another name shuteria pampaniniana, thorn Flos Carthami, Flos Carthami, golden red flower.Warm in nature, acrid in the mouth, the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.When ancients often have what blood in vivo, often add the Flos Carthami tate.Bundle is boiled available one day twice foot bath, applicable various varicosis, and peripheral neuritis, blood circulation is bad, lower limb numbness or the congestion such as livid purple.
Radix Inulae: the dry root of feverfew Radix Inulae Inula helenium L. or total shape Radix Inulae Inula racemosa Hook. f..[another name]: Radix Aristolochiae, Qi Muxiang, Radix Inulae, agate slave (Tibetan language), property of medicine classification]: temporary unfiled nature and flavor with return through: hot, bitter, temperature.Return liver, spleen channel.[function with cure mainly]: invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, pain relieving is antiabortive.Be used for the breast side of body, abdominal distention, vomiting dysentery, the breast side of body is dampened, and feels a pain in the chest when breathing and has a pain, frequent fetal movement.
Caulis menispermi: be the dry root and rhizome of vitaceae Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) Ampelopsis sinica (Miq) W.T.Wang.[meridian distribution of property and flavor] light, put down into kidney channel [effect] enriching yin and nourishing kidney.Control lumbago, scrofula.The Chinese medicine bitter in the mouth, cold in nature.Slightly poisonous.Heat-clearing and toxic substances removing, throat, reducing swelling and alleviating pain, anticancer.Chinese medicine is controlled laryngopharynx swelling and pain, cough due to lung-heat, aphtha, gingivitis, jaundice, enteritis, dysentery, pyelonephritis, mumps, carbuncle pyogenic infections from tumour or sore, worm venom, esophageal carcinoma, gastric cancer.Mongolian medicine is controlled heat in blood, " association's day " heat, and bone heat, hot " Xi Riwu element " disease, erysipelas, thirsty, feel sick vomiting, dermatosis." detailed outline is picked up any lost article from the road ": control lumbago.Scrofula.Caulis menispermi has good flesh pine effect, and its interaction property and curare are together.Sinomenine also has the effect of flesh pine.The sinomenine of high dose has contraction to the cat bronchus, and this effect is relevant with its release histamine.Dauricine has spasmolysis to intestinal smooth muscle.Sinomenine and sinomenine all have hypotensive effect, and this effect may be due to its direct blood vessel dilating.Dauricine also has hypotensive effect, and its principle is central, and is also relevant with the block nerves joint with direct blood vessel dilating simultaneously.Dauricine has stronger inhibitory action to streptococcus pneumoniae, hemophilus influenza.Sinomenine and Sinomenium acutum have the tuberculosis effect, and dysentery bacterium and ameba are all had inhibitory action; And all can suppress or kill in vivo and in vitro the cell of ehrlich ascites carcinoma.Sinomenine and sinomenine also have antiinflammatory, analgesia and stimulate the effect of mice reticuloendothelial system phagocytic function.Dauricine has antiinflammatory and Antitussive and Expectorant Effect.
Radix seu Folium Rubi Cochinchinensis: be dry root and the rhizome of rosaceous plant salem-rose Rubus rosaefolius smith.[another name] little fierce tiger, chicken aciculum, [nature and flavor] hardship; Hot; Temperature [return through] liver; Kidney channel [function cures mainly] expelling wind and removing dampness, promoting the circulation of QI to relieve pain.The main air pain of dampness syndrome, traumatic pain, lumbago and skelalgia [usage and dosage] is for oral administration: fry in shallow oil soup, 6-18g.[each is discussed] " the Chinese herbal medicine handbook is commonly used in Hainan Island: wind dispelling, dehumidifying, circulation of qi promoting.Control lumbago and skelalgia, extremity arthralgia pain, rheumatic ostalgia.
Camphora: be the dried branch of canella Cinnamomum camphora (L) sied., leaf and root.Another name: splendid brain, camphor, brain, oily brain, tree brain.Gui Jing: the heart, spleen channel.Effect: orifice opening; Qi stagnation removing; Ward off foul; Killing parasites for relieving itching; Reducing swelling and alleviating pain
Mentholum: a kind of chemical agent, Mentholum system is by extracting in the leaf of Herba Menthae and the stem, white crystal, molecular formula C10H20O is the main component in Herba Menthae and the lavender quintessence oil.In the world, China and Brazil is main natural Herba Menthae manufacturing country, and the annual production of Oleum menthae all reaches 2000-3000t.Mentholum and racementhol all can be used as toothpaste; Perfume; The odorant of beverage and confection etc.As excitants, act on skin or mucosa pharmaceutically, refrigerant itching-relieving action is arranged; The carminative that can be used as for oral administration is used for headache and nose; Pharynx; Laryngitis etc.Its ester is used for spice and medicine.
Rhizoma Zingiberis: the dry rhizome of zingiber Zingiber officinale Rosc..[nature and flavor, return through] acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.[effect] warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.[curing mainly] coldness and pain in the epigastrium; Vomiting; Have loose bowels, YANG-depletion is fainted contrary; Cold fluid-retention is breathed with cough; Arthralgia due to cold-dampnes.
Prescription Caulis Gneti of the present invention: nature and flavor are bitter, warm, return Liver Channel, expelling wind and removing dampness, promoting blood circulation to remove blood stasis; The pinaster pen; Five tastes rattan: nature and flavor are hot, bitter, cool, expelling wind and removing dampness; Eliminating stasis to stop pain; Caulis et folium gaultheriae yunnanensis: nature and flavor are hot, temperature, expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral; Radix Zanthoxyli: nature and flavor are bitter, hot, and are flat, return liver, stomach warp, promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral; Flos Carthami: warm in nature, acrid in the mouth, the latus rectum of invigorating blood circulation, eliminating stasis to stop pain; Radix Inulae: hot, bitter, temperature is returned liver, spleen channel, and contusion is controlled in pain relieving; Caulis menispermi: nature and flavor are light, flat, enter kidney channel, and lumbago is controlled in enriching yin and nourishing kidney, and heat-clearing and toxic substances removing, reducing swelling and alleviating pain, Caulis menispermi also have good flesh pine effect; Radix seu Folium Rubi Cochinchinensis: nature and flavor are bitter, hot, warm, return liver, kidney channel, expelling wind and removing dampness, promoting the circulation of QI to relieve pain; Rhizoma Zingiberis: acrid in the mouth, hot in nature, return spleen, stomach, the heart, lung meridian, warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation; Camphora: return through the heart, spleen channel, orifice opening, antipruritic, reducing swelling and alleviating pain; Mentholum: act on skin or mucosa, refrigerant itching-relieving action is arranged.More than all medicines join five through science promoting blood circulation to remove blood stasis arranged, reducing swelling and alleviating pain, wind dispelling collateral dredging, cold relieving removing dampness effect are used for the treatment of Fengshi Guanjie pain, arthralgia due to cold, treating swelling and pain by traumatic injury, acute jerk contused wound.The using method of product of the present invention is: suitable amount used externally, wiped the affected part 10 minutes, 3 times on the one at every turn.
The invention has the beneficial effects as follows:
1, the present invention's external-use tincture medicine for the treatment of Fengshi Guanjie pain and treating swelling and pain by traumatic injury has that expelling wind and cold, Huoxue San " are crazy, the effect of reducing swelling and alleviating pain, and the common sympton due to treatment rheumatic arthralgia and the acute jerk contused wound is significantly improved effect;
2, it is wide that the present invention treats the external-use tincture medicine material source of Fengshi Guanjie pain and treating swelling and pain by traumatic injury, obtains easily;
3, the present invention's external-use tincture pharmaceutical preparation for the treatment of Fengshi Guanjie pain and treating swelling and pain by traumatic injury can extract and preserve the main active of ingredients in the prescription effectively;
4, the present invention's external-use tincture medicine for the treatment of Fengshi Guanjie pain and treating swelling and pain by traumatic injury has no side effect, and uses safety, convenient, has enriched treatment Fengshi Guanjie pain and treating swelling and pain by traumatic injury patient's the medication range of choice.
5, Fengshi Guanjie pain is mostly because wind-cold damp pathogen invasion and attack human body, the impatency meridians, due to QI-blood circulation is not smooth, and traumatic injury can cause Yu Xue Bi resistance meridians, these two kinds of situations cause clinically usually with muscle, muscles and bones, ache in the joint, numb, swelling, the symptoms such as joint stuffiness, therefore, the inventor is according to the theory of Chinese medical science of " general rule is not sick; pain is then obstructed ", for the upper pathogensis of crossing disease, formulated the Therapeutic Principle of " reducing swelling and alleviating pain; blood circulation promoting and blood stasis dispelling; wind dispelling collateral dredging; cold relieving removing dampness ", filter out prescription of the present invention, the Chinese medicine preparation of preparation is to traumatic injury thus, Fengshi Guanjie pain has significant curative effect, clinically applicable to for example Fengshi Guanjie pain, treating swelling and pain by traumatic injury, acute jerk contused wound, scapulohumeral periarthritis, the diseases such as innominate toxic swelling.
The discriminating of product of the present invention: can adopt following several method:
1, the thin layer differential method of Rhizoma Zingiberis,
Get this product 30ml, evaporate to dryness, residue add dehydrated alcohol 3ml and petroleum ether (60～90 ℃) 9ml makes dissolving, filter, and, filtrate evaporate to dryness, residue add dehydrated alcohol 1ml, make dissolving, as need testing solution.Other gets the negative sample 30ml that lacks Rhizoma Zingiberis and is made in the same way of negative controls, gets Rhizoma Zingiberis control medicinal material 1g again, adds methanol 10ml, and reflux 30 minutes filters, and filtrate evaporate to dryness, residue add methanol 1ml makes dissolving, in contrast medical material solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw each 5 μ l of above-mentioned three kinds of solution, put respectively on same silica gel g thin-layer plate take sodium carboxymethyl cellulose as adhesive, take hexane-acetone-methanol (9:2.5:1) as developing solvent, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, the fluorescence speckle of aobvious same color.
2, Mentholum counter point,
Get the Mentholum reference substance, add methanol and make the solution that 1ml contains 2mg, in contrast product solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw need testing solution 10 μ l and above-mentioned reference substance solution 2 μ l under the item of [discriminating] (1), put respectively on same silica gel g thin-layer plate take sodium carboxymethyl cellulose as adhesive, take normal hexane-ethyl acetate (8.5:1.5) as developing solvent, launch, take out, dry, spray is with vanillin sulphuric acid test solution, and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance on, the speckle of aobvious same color.
The Determination of menthol algoscopy is calculated: precision is drawn reference substance solution and each 1ml of need testing solution respectively, and inject gas chromatograph is measured, and calculates, and get final product.The every 1ml of this product contains Mentholum (C10H20O) must not be lower than 9.0mg.
3, Camphora relative method,
Get this product 2ml, add 60% ethanol dilution to 10ml, as need testing solution.Other gets negative sample 2ml and is made in the same way of negative sample solution, gets Camphora reference substance 201mg again, adds 60% ethanol 10ml and makes dissolving, in contrast product solution.According to gas chromatography, an appendix VI of Chinese Pharmacopoeia version in 2005 E test, take Polyethylene Glycol (PEG)-20M as immobile phase, coating concentration is 10%; Column temperature 150+10 ℃, draw respectively above-mentioned three kinds of solution 1-2 μ l, inject gas chromatograph presents the chromatographic peak identical with the reference substance retention time in the test sample chromatograph respectively.
4, Radix Inulae differential method
The Radix Inulae medical material is differentiated and tested: method is; get this product 30ml; add the petroleum ether jolting and extract 2 times; each 20ml; merge petroleum ether liquid extracting solution, evaporate to dryness, residue add ethyl acetate 1ml; make dissolving; as need testing solution, and other gets negative sample 30ml and is made in the same way of negative sample solution, gets Radix Aristolochiae control medicinal material 1g again; add petroleum ether 2ml dipping and spend the night; filter, filtrate is medical material solution in contrast, according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B) test; draw each 10 μ l of above-mentioned 3 kinds of solution; put respectively on same silica gel g thin-layer plate take sodium carboxymethyl cellulose as adhesive, take petroleum ether-ethyl acetate (8.5:1.5) as developing solvent, launch; take out, dry.Spray is with 2-4-dinitrophenylhydrazine test solution, in the test sample chromatograph, with the speckle of the aobvious same color in the corresponding position of control medicinal material.
The specific embodiment
Embodiment 1:
(1) whenever make the required primary raw material of the external-use tincture medicine of 1000ml by following weight proportion:
Caulis Gneti 30g, a pinaster 20g, five tastes rattan 10g, Caulis et folium gaultheriae yunnanensis 15g, Radix Zanthoxyli 10g, Flos Carthami 15g, Camphor tree, brain 15g, Radix Inulae 10g, Caulis menispermi 10g, Radix seu Folium Rubi Cochinchinensis 15g, Rhizoma Zingiberis 15g, Mentholum 15g;
(2) the present invention treats the preparation method of the external-use tincture medicine of Fengshi Guanjie pain and treating swelling and pain by traumatic injury and is:
A: the crude drug of described parts by weight: Caulis Gneti, the pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis, Rhizoma Zingiberis is ground into coarse powder;
B: the percolation (an appendix I of Chinese Pharmacopoeia version in 2000 O) under the former medicine photograph fluid extract of step a coarse powder and the extractum item, make solvent with 70% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, collect the about 800ml of liquid that just filters, device is preserved in addition;
C: continue percolation till 12 times of amounts of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
D: other gets Camphora, Mentholum, adds ethanol 50ml and makes dissolving, adds in the mentioned solution, adds ethanol to ormal weight, shakes up, and leaves standstill 24 hours, filters, and namely gets the finished product five pines of the present invention tincture that swells and ache.
(3) the above pulverizing medicinal materials can adopt the conventional method such as independent pulverizing, co-grinding, dry pulverization process, waterproof pulverization.
Embodiment 2:
(1) whenever make the required primary raw material of the external-use tincture medicine of 1000ml by following weight proportion:
Caulis Gneti 36g, a pinaster 20g, five tastes rattan 15g, Caulis et folium gaultheriae yunnanensis 15g, Radix Zanthoxyli 24g, Flos Carthami 10g, Camphora 10g, Radix Inulae 10g, Caulis menispermi 15g, Radix seu Folium Rubi Cochinchinensis 15g, Rhizoma Zingiberis 15g, Mentholum 15g;
(2) the present invention treats the preparation method of the external-use tincture medicine of Fengshi Guanjie pain and treating swelling and pain by traumatic injury and is:
A: the crude drug of described parts by weight: Caulis Gneti, the pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis, Rhizoma Zingiberis is ground into coarse powder;
B: the percolation (an appendix I of Chinese Pharmacopoeia version in 2000 O) under the former medicine photograph fluid extract of step a coarse powder and the extractum item, make solvent with 70% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, collect the about 800ml of liquid that just filters, device is preserved in addition; C: continue percolation till 12 times of amounts of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
D: other gets Camphora, Mentholum, adds ethanol 50ml and makes dissolving, adds in the mentioned solution, adds ethanol to ormal weight, shakes up, and leaves standstill 24 hours, filters, and namely gets the finished product five pines of the present invention tincture that swells and ache.
(3) the above pulverizing medicinal materials can adopt the conventional method such as independent pulverizing, co-grinding, dry pulverization process, waterproof pulverization.
Embodiment 3:
(1) whenever make the required primary raw material of the external-use tincture medicine of 1000ml by following weight proportion:
Caulis Gneti 30g, a pinaster 15g, five tastes rattan 12g, Caulis et folium gaultheriae yunnanensis 12g, Radix Zanthoxyli 20g, Flos Carthami 10g, Camphora 10g, Radix Inulae 10g, Caulis menispermi 15g, Radix seu Folium Rubi Cochinchinensis 15g, Rhizoma Zingiberis 15g, Mentholum 15g
(2) the present invention treats the preparation method of the external-use tincture medicine of Fengshi Guanjie pain and treating swelling and pain by traumatic injury and is:
A: the crude drug of described parts by weight: Caulis Gneti, the pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis, Rhizoma Zingiberis is ground into coarse powder;
B: the percolation (an appendix I of Chinese Pharmacopoeia version in 2000 O) under the former medicine photograph fluid extract of step a coarse powder and the extractum item, make solvent with 70% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, collect the about 800ml of liquid that just filters, device is preserved in addition; C: continue percolation till 12 times of amounts of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
D: other gets Camphora, Mentholum, adds ethanol 50ml and makes dissolving, adds in the mentioned solution, adds ethanol to ormal weight, shakes up, and leaves standstill 24 hours, filters, and namely gets the finished product five pines of the present invention tincture that swells and ache.
(3) the above pulverizing medicinal materials can adopt the conventional method such as independent pulverizing, co-grinding, dry pulverization process, waterproof pulverization.
Embodiment 4, spray preparation (1000ml):
Caulis Gneti 25g, a pinaster 10g, five tastes rattan 5g, Caulis et folium gaultheriae yunnanensis 5g, Radix Zanthoxyli 14g, Flos Carthami 5g, Camphora 5g, Radix Inulae 5g, Caulis menispermi 5g, Radix seu Folium Rubi Cochinchinensis 5g, Rhizoma Zingiberis 5g, lotus brain 5g;
(1) weighs by weight crude drug: Caulis Gneti, pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis and ginger powder are broken into coarse powder;
(2) the former medicine of step (1) coarse powder according to the percolation under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, the about 800ml of liquid that filters at the beginning of the collection preserves;
(3) continue percolation till 12 times of amounts of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
(4) get in addition Camphora, Mentholum, add propylene glycol 50ml and make dissolving, add in the mentioned solution, and add surfactant tween or the span of 0.1-10 gram, 0.5-1 the flavouring agent of gram adds ethanol to ormal weight, shakes up, and leaves standstill 24 hours, filter, in the spray bottle of packing into, namely get the spray product.
Embodiment 5, spray preparation (1000ml):
Caulis Gneti 30g, a pinaster 20g, five tastes rattan 14g, Caulis et folium gaultheriae yunnanensis 10g, Radix Zanthoxyli 18g, Flos Carthami 8g, Camphora 9g, Radix Inulae 10g, Caulis menispermi 15g, Radix seu Folium Rubi Cochinchinensis 15g, Rhizoma Zingiberis 15g, lotus brain 15g;
(1) weighs by weight crude drug: Caulis Gneti, pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis and ginger powder are broken into coarse powder;
(2) the former medicine of step (1) coarse powder according to the percolation under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, the about 800ml of liquid that filters at the beginning of the collection preserves;
(3) continue percolation till 12 times of amounts of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
(4) get in addition Camphora, Mentholum, add propylene glycol 50ml and make dissolving, add in the mentioned solution, and add surfactant tween or the span of 0.1-10 gram, 0.5-1 the flavouring agent of gram adds ethanol to ormal weight, shakes up, and leaves standstill 24 hours, filter, in the spray bottle of packing into, namely get the spray product.
Clinical verification:
Five pines are swollen and ache tincture system according to the ethnic drug preparation of Guangxi Minority experience and traditional Chinese medical theory development, have the cold expelling of invigorating blood circulation, and the effect of reducing swelling and alleviating pain, expelling wind and removing dampness is used for the limbs joint pain, acute jerk contused wound of anemofrigid-damp arthralgia etc.In order to verify its effect, with reference to " guideline of clinical investigations of new Chinese medicine treatment numbness disease " [1] and " guideline of clinical investigations of new Chinese medicine treatment acute soft tissue injury " [2], the first Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi (120 example), Guangxi Chinese medicine the second Affiliated Hospital (100 example) and The People's Hospital, Guangxi Zhuang Autonomous Region's (100 example) carried out clinical trial to the five pines tincture that swells and ache before 3 years, the result is summarized as follows:
1, treatment group obvious effective rate, effective percentage are respectively 64.2%, 21.7%, and total effective rate is 85.8%; Matched group obvious effective rate, effective percentage are respectively 57.5%, 25.8%, and total effective rate is 83.3%.Two groups relatively without significance.Sick and acute jerk contused wound all has preferably analgesic effect to tincture to numbness to point out five pines to swell and ache, and medicine is similar to contrasting.
2, the different sick efficacy results of planting are distinguished, and two groups to disadvantage and the equal no significant difference of acute jerk contused wound analgesic effect.
3, the clinical symptoms efficacy result shows, after two groups of curative effects, the symptoms such as the conscious pain of patient, tenderness, swelling moving obstacle all have clear improvement.But two groups relatively, no significant difference.Point out the five pines tincture that swells and ache can obviously improve disadvantage and acute jerk contused wound patient's clinical symptoms, similar to the contrast medicine.
4, pain relief, extinction time comparative result show after the treatment, and five pines are swollen and ache tincture to the relieving pain of disadvantage and acute jerk contused wound, and are similar to the contrast medicine.
5, this research to 200 routine patients carried out blood, just conventional teaching notes are poor, the heart, liver, kidney function test are not all found obvious adverse reaction and toxic and side effects.Prompting this product is clinical safe and reliable.
The swell and ache tincture stability test report of five pines
The tincture production of swelling and ache of " specification requirement of study of tcm new drug " of promulgating by National Drug Administration and five pines has been carried out stability test with drug standard (trying) to this product three batch samples, and the result is as follows:
1 test specimen: the large pharmaceutcal corporation, Ltd of Guangxi Yulin Da Jin produces lot number 030104,030112,030118.
2 investigation projects: character, discriminating, inspection, assay, limit test of microbe.
3 test methods: sample is going on the market with under the terms of packing, in room temperature (8～30 ℃), preserve under relative humidity 40～95% states, investigate by the five pines tincture quality standard that swells and ache, the limit test of microbe project is by " microorganism a limit examine of Chinese pharmacopoeia version in 2000 method check.Except of that month (0 month) once, the 3rd month, the 6th month, the 12nd month and each examination in 18th month are once investigated this product character identification, inspection, assay and limit test of microbe project.
4 result of the tests: see Table 1,2,3.
5 conclusions: the tincture production of swelling and ache of " the study of tcm new drug specification requirement " that this product is promulgated by National Drug Administration and five pines is all up to specification with character, discriminating, inspection, the assay of drug standard (trying) three batch samples.Limit test of microbe antibacterial number average is less than 100/ml, and mycete all is less than 100/ml,, escherichia coli, the demodicid mite that lives all do not detect.Be that pass the test is all up to specification.Show this product under listing drug packaging condition, 18 months drug qualities of preservation are stable under room temperature (8～30 ℃), relative humidity 40～95% conditions, are 2 years so decide this product shelf-life.
Drug standard of the present invention also can use the thin layer of Rhizoma Zingiberis to differentiate.Method is: get this product 30ml, evaporate to dryness, residue add dehydrated alcohol 3ml and petroleum ether (60～90 ℃) 9ml makes dissolving, filters, and filtrate evaporate to dryness, residue add dehydrated alcohol 1ml, make dissolving, as need testing solution.Other gets the negative sample 30ml that lacks Rhizoma Zingiberis and is made in the same way of negative controls, gets Rhizoma Zingiberis control medicinal material 1g again, adds methanol 10ml, and reflux 30 minutes filters, and filtrate evaporate to dryness, residue add methanol 1ml makes dissolving, in contrast medical material solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw each 5 μ l of above-mentioned three kinds of solution, put respectively on same silica gel g thin-layer plate take sodium carboxymethyl cellulose as adhesive, take hexane-acetone-methanol (9:2.5:1) as developing solvent, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, the fluorescence speckle of aobvious same color.
(2) this discrimination method of proof basic feasible solution within the tentative phase is not so do revision.
(3) this discrimination method is the discrimination method of Camphora medical material newly-increased within the tentative phase.Get this product 2ml, add 60% ethanol dilution to 10ml, as need testing solution.Other gets negative sample 2ml and is made in the same way of negative sample solution, gets Camphora reference substance 201mg again, adds 60% ethanol 10ml and makes dissolving, in contrast product solution.According to gas chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 E) test, take Polyethylene Glycol (PEG)-20M as immobile phase, coating concentration is 10%; Column temperature 150+10 ℃, draw respectively above-mentioned three kinds of solution 1-2 μ l, inject gas chromatograph presents the chromatographic peak identical with the reference substance retention time in the test sample chromatograph respectively.This test method favorable reproducibility, specificity is strong, and is negative noiseless, so the income text.
Claims (7)
1. external preparation for the treatment of Fengshi Guanjie pain and treating swelling and pain by traumatic injury is characterized in that: make the required primary raw material of the external preparation medicine of 1000ml by following weight proportion: Caulis Gneti 26-46g, a pinaster 10-30g, five tastes rattan 5-25g, Caulis et folium gaultheriae yunnanensis 5-25g, Radix Zanthoxyli 14-34g, Flos Carthami 5-20g, Camphora 5-20g, Radix Inulae 5-20g, Caulis menispermi 5-25g, Radix seu Folium Rubi Cochinchinensis 5-25g, Rhizoma Zingiberis 5-25g, lotus brain 5-25g; Described external preparation comprises tincture and spray.
2. the external preparation for the treatment of Fengshi Guanjie pain according to claim 1 and treating swelling and pain by traumatic injury, it is characterized in that: the preparation method of tincture is:
(1) weighs by weight crude drug: Caulis Gneti, pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis and ginger powder are broken into coarse powder;
(2) the former medicine of step (1) coarse powder according to the percolation under fluid extract and the extractum item, make solvent with volumetric concentration 60-80% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, the about 800ml of liquid that filters at the beginning of the collection preserves;
(3) continue percolation till 12 times of weight of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
(4) get in addition Camphora, Mentholum, add ethanol 50ml and make dissolving, add in the mentioned solution, add ethanol to ormal weight, shake up, left standstill 24 hours, filter, bottling namely gets product.
3. the external preparation for the treatment of Fengshi Guanjie pain according to claim 1 and treating swelling and pain by traumatic injury, it is characterized in that: the method for preparing spray is:
(1) weighs by weight crude drug: Caulis Gneti, pinaster pen, five tastes rattan, Caulis et folium gaultheriae yunnanensis, Radix Zanthoxyli, Flos Carthami, Radix Inulae, Caulis menispermi, Radix seu Folium Rubi Cochinchinensis and ginger powder are broken into coarse powder;
(2) the former medicine of step (1) coarse powder according to the percolation under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 48 hours, with the speed of the about 1～2ml of per minute percolation slowly, the about 800ml of liquid that filters at the beginning of the collection preserves;
(3) continue percolation till 12 times of amounts of medical material amount, collect the continuous liquid of filtering, Recycled ethanol is concentrated into relative density and is 1.03～1.05 clear paste under 40-70 ℃ of condition, let cool, and incorporates the liquid of just filtering into;
(4) get in addition Camphora, Mentholum, add propylene glycol 50ml and make dissolving, add in the mentioned solution, and add surfactant tween or the span of 0.1-10 gram, 0.5-1 the flavouring agent of gram adds ethanol to ormal weight, shakes up, and leaves standstill 24 hours, filter, in the spray bottle of packing into, namely get the spray product.
4. the external preparation for the treatment of Fengshi Guanjie pain claimed in claim 1 and treating swelling and pain by traumatic injury, it is characterized in that: quality standard uses the thin layer differential method of Rhizoma Zingiberis: get product 30ml, evaporate to dryness, residue adds 60～90 ℃ of dehydrated alcohol 3ml and petroleum ether, and 9ml makes dissolving, filters, the filtrate evaporate to dryness, residue adds dehydrated alcohol 1ml, makes dissolving, as need testing solution;
Other gets the negative sample 30ml that lacks Rhizoma Zingiberis and is made in the same way of negative controls, get again Rhizoma Zingiberis control medicinal material 1g, add methanol 10ml, reflux 30 minutes filters, the filtrate evaporate to dryness, residue adds methanol 1ml makes dissolving, and medical material solution is tested according to thin layer chromatography in contrast, draw each 5 μ l of above-mentioned three kinds of solution, put respectively on same silica gel g thin-layer plate take sodium carboxymethyl cellulose as adhesive, take hexane-acetone-methanol 9:2.5:1 as developing solvent, launch, take out, dry, put under the ultra-violet lamp 365nm and inspect, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, the fluorescence speckle of aobvious same color.
5. the external preparation for the treatment of Fengshi Guanjie pain claimed in claim 1 and treating swelling and pain by traumatic injury is characterized in that: quality standard uses the Camphora relative method, gets product 2ml, adds 60% ethanol dilution to 10ml, as need testing solution; Other gets negative sample 2ml and is made in the same way of negative sample solution, gets Camphora reference substance 201mg again, adds 60% ethanol 10ml and makes dissolving, in contrast product solution; According to the gas chromatography test, take Polyethylene Glycol-20M as immobile phase, coating concentration is 10%; Column temperature 150+10 ℃, draw respectively above-mentioned three kinds of solution 1-2 μ l, inject gas chromatograph presents the chromatographic peak identical with the reference substance retention time in the test sample chromatograph respectively.
6. the external preparation for the treatment of Fengshi Guanjie pain claimed in claim 1 and treating swelling and pain by traumatic injury, it is characterized in that: quality standard uses Radix Inulae medical material differential method: get product 30ml, adding the petroleum ether jolting extracts 2 times, each 20ml, merge petroleum ether liquid extracting solution, evaporate to dryness, residue add ethyl acetate 1ml, make dissolving, as need testing solution, other gets negative sample 30ml and is made in the same way of negative sample solution, gets Radix Aristolochiae control medicinal material 1g again, adds petroleum ether 2ml dipping and spends the night, filter, filtrate is medical material solution in contrast, according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B) test, draws each 10 μ l of above-mentioned 3 kinds of solution, put respectively on same silica gel g thin-layer plate take sodium carboxymethyl cellulose as adhesive, take petroleum ether-ethyl acetate weight ratio 8.5:1.5 as developing solvent, launch, take out, dry, spray is with 2-4-dinitrophenylhydrazine test solution, in the test sample chromatograph, with the speckle of the aobvious same color in the corresponding position of control medicinal material.
7. the external preparation for the treatment of Fengshi Guanjie pain claimed in claim 1 and treating swelling and pain by traumatic injury, it is characterized in that: quality standard uses the Mentholum counter point, get product 2ml, add 60% ethanol dilution to 10ml, as need testing solution, other gets negative sample 2ml and is made in the same way of negative sample solution, get again Camphora reference substance 201mg, add 60% ethanol 10ml and make dissolving, product solution is take Polyethylene Glycol (PEG)-20M as immobile phase in contrast, and coating concentration is 10%; Column temperature 150+10 ℃, draw respectively above-mentioned three kinds of solution 1-2 μ l, inject gas chromatograph presents the chromatographic peak identical with the reference substance retention time in the test sample chromatograph respectively.
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| CN104523506A (en) * | 2014-12-16 | 2015-04-22 | 广西科技大学 | Application of securidaca inappendiculata extractive in preparation of oral care products for treating gingival ache |
| CN105456533A (en) * | 2015-12-28 | 2016-04-06 | 青岛昌安达药业有限公司 | Traditional Chinese medicine formula for treating ankylosing spondylitis |
| CN114699363A (en) * | 2022-06-08 | 2022-07-05 | 江西中医药大学附属医院 | Traditional Chinese medicine wax mud for osteoarthritis and preparation method thereof |
| CN115201398A (en) * | 2021-04-09 | 2022-10-18 | 桂林三金药业股份有限公司 | Quality detection method for medicinal material of caulis et folium piperis longi, extract and preparation thereof |
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| CN102716261A (en) * | 2012-07-02 | 2012-10-10 | 裴保法 | Wind-damp expelling traditional Chinese medicine powder |
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| CN1698682A (en) * | 2004-05-19 | 2005-11-23 | 广西玉林制药有限责任公司 | Chinese traditional medicine composition with effects of activating blood circulation, dissipating blood stasis, relaxing, activating the tendons, reducing swelling and easing pain and preparation met |
| CN101703667A (en) * | 2009-06-03 | 2010-05-12 | 佛山冯了性药业有限公司 | Brown red medicament for treating traumatic injuries and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104523506A (en) * | 2014-12-16 | 2015-04-22 | 广西科技大学 | Application of securidaca inappendiculata extractive in preparation of oral care products for treating gingival ache |
| CN105456533A (en) * | 2015-12-28 | 2016-04-06 | 青岛昌安达药业有限公司 | Traditional Chinese medicine formula for treating ankylosing spondylitis |
| CN115201398A (en) * | 2021-04-09 | 2022-10-18 | 桂林三金药业股份有限公司 | Quality detection method for medicinal material of caulis et folium piperis longi, extract and preparation thereof |
| CN115201398B (en) * | 2021-04-09 | 2024-05-10 | 桂林三金药业股份有限公司 | Quality detection method for radix seu herba Kadsurae Longipedunculatae, extract and preparation thereof |
| CN114699363A (en) * | 2022-06-08 | 2022-07-05 | 江西中医药大学附属医院 | Traditional Chinese medicine wax mud for osteoarthritis and preparation method thereof |
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