CN102846842A - Topical gel for treating rheumatic arthritis - Google Patents
Topical gel for treating rheumatic arthritis Download PDFInfo
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- CN102846842A CN102846842A CN2012103919606A CN201210391960A CN102846842A CN 102846842 A CN102846842 A CN 102846842A CN 2012103919606 A CN2012103919606 A CN 2012103919606A CN 201210391960 A CN201210391960 A CN 201210391960A CN 102846842 A CN102846842 A CN 102846842A
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Abstract
The invention relates to a topical gel for treating rheumatic arthritis, and the topical gel can be used for effectively solving the problems of low curative effects, large side effects, high cost and low transdermal absorption rate of the existing medicine. The technical scheme of the topical gel for solving the problems is as follows: the gel is prepared from the following raw materials by weight: 100-220g of traditional Chinese medicine extract, 25-50g of carbomer, 15-55g of glycerol, 80-260g of propylene glycol, 5-10g of essential oil of clove, 0.10-0.25 g of ethylene diamine tetraacetic acid, 1-2g of ethylparaben, 15-30g of borneol, 10-15g of camphor, 15-30g of menthol, 200-400g of ethanol with volume concentration of 95%, and 450-800g of water. The topical gel provided by the invention has the advantages of favorable absorption effect, small irritation to skin, no toxic and side effects, stable curative effect, safety and reliability. The topical gel is an innovation of a medicine for treating rheumatic arthritis.
Description
Technical field
The present invention relates to medicine, particularly a kind of exterior-applied gel for the treatment of rheumatic arthritis.
Background technology
Rheumatic arthritis class disease is commonly encountered diseases, the frequently-occurring disease of mid-aged population, this disease course is long, treatment slowly, be difficult to radical cure, the lighter's affected part arthralgia, the arthroncus of severe one affected part, distortion, hurt like hell, even can not walk, bring many harm for patient's life and health, the Western medicine for oral administration for the treatment of rheumatic arthritis class disease is a lot, and the curative effect that these medicines have is low, side effect is large, and is dirty etc. such as infringement liver, stomach, hormone medicine causes that human body is got fat, edema, what have is expensive, and is difficult to effect a permanent cure, and only plays lenitive effect; The Chinese medicine for oral administration that some treatment rheumatic arthritis class diseases are arranged, but curative effect is not ideal, and price is high, general patient is difficult to bear, and traditional external use plaster skin affinity is poor, airtight, easily produce sensitization, patient uses inconvenience, and generally can only load fat-soluble medicine composition, has significant limitation, can only contain on a small quantity medicine, transdermal absorption factor is low, is difficult to the curative effect that reaches desirable.Therefore, the improvement for the treatment of rheumatic arthritis class disease medicament is the problem of needing at present solution badly.
Summary of the invention
For above-mentioned situation, be to solve the defective of prior art, the present invention's purpose just provides a kind of exterior-applied gel for the treatment of rheumatic arthritis, can solve effectively that existing curative effect of medication is low, side effect is large, and is expensive, the problem that transdermal absorption factor is low.
The technical scheme that the present invention solves is, this gel is by weighing scale: Chinese medicine extraction extractum 100～220g, carbomer 25～50g, glycerol 15～55g, propylene glycol 80～260g, Flos Caryophylli volatile oil 5～10g, disodiumedetate 0.10～0.25g, ethyl hydroxybenzoate 1～2g, Borneolum Syntheticum 15～30g, Camphora 10～15g, Mentholum 15～30g, volumetric concentration is that 95% ethanol 200～400g and water 450～800g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by per 5～10g Flos Caryophylli, collects volatile oil, namely gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 5～10g, Fructus Capsici 10～20g, Rhizoma Chuanxiong 15～20g, Radix Saposhnikoviae 15～20g, the Flos Caryophylli medicinal residues that Radix Notoginseng 10～15g and per 5～10g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and per 5～10g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
Medicine of the present invention easily absorbs, and is little to skin irritation, have no side effect, and stable curative effect, safe and reliable, be the innovation on the treatment rheumatic arthritis medicine.
The specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is described in further detail.
Embodiment 1
This gel is by weighing scale: Chinese medicine extraction extractum 100g, carbomer 50g, glycerol 15g, propylene glycol 260g, Flos Caryophylli volatile oil 10g, disodiumedetate 0.10g, ethyl hydroxybenzoate 1g, Borneolum Syntheticum 30g, Camphora 10g, Mentholum 30g, volumetric concentration is that 95% ethanol 200g and water 450g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by every 5g Flos Caryophylli, collects volatile oil, gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 10g, Fructus Capsici 10g, Rhizoma Chuanxiong 20g, Radix Saposhnikoviae 15g, the Flos Caryophylli medicinal residues that Radix Notoginseng 15g and every 5g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and every 5g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
Embodiment 2
This gel is by weighing scale: Chinese medicine extraction extractum 160g, carbomer 33g, glycerol 35g, propylene glycol 170g, Flos Caryophylli volatile oil 8g, disodiumedetate 0.18g, ethyl hydroxybenzoate 1.5g, Borneolum Syntheticum 22g, Camphora 12g, Mentholum 23g, volumetric concentration is that 95% ethanol 300g and water 630g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by every 8g Flos Caryophylli, collects volatile oil, gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 8g, Fructus Capsici 15g, Rhizoma Chuanxiong 18g, Radix Saposhnikoviae 18g, the Flos Caryophylli medicinal residues that Radix Notoginseng 12g and every 8g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and every 8g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
Embodiment 3
This gel is by weighing scale: Chinese medicine extraction extractum 220g, carbomer 25g, glycerol 55g, propylene glycol 80g, Flos Caryophylli volatile oil 5g, disodiumedetate 0.25g, ethyl hydroxybenzoate 2g, Borneolum Syntheticum 15g, Camphora 15g, Mentholum 15g, volumetric concentration is that 95% ethanol 400g and water 800g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by every 10g Flos Caryophylli, collects volatile oil, gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 5g, Fructus Capsici 20g, Rhizoma Chuanxiong 15g, Radix Saposhnikoviae 20g, the Flos Caryophylli medicinal residues that Radix Notoginseng 10g and every 10g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and every 10g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
(1),The present invention stipulates according to national new drug approval, has carried out series of experiments, and the result is as follows:
Acute toxicity testing:
Get 60 of Cavia porcelluss, random packet, depilation, exterior-applied gel experiment, successive administration 15 days; The result: none animal dead of large small dose group of the complete and damaged skin of Cavia porcellus, each organizes the activity of Cavia porcellus, defecation, mental status etc. are all normal, obvious whole body toxicity is not also found in the reactions such as damaged skin NIP, oozing of blood, and the gel application safety of the present invention's preparation is described.
The skin irritation test
The prepared gel of the present invention to the Cavia porcellus intact skin without obvious irritation; Less to the damaged skin zest, erythema, infection or the skin irritation phenomenons such as redness, edema do not appear in the part.
Hypersensitive test
Get 30 of Cavia porcelluss, male and female half and half, random packet is tested; The result: after using the gel of the present invention's preparation, the hair color of Cavia porcellus, the mental status etc. do not have abnormal phenomena, illustrate that the gel of the present invention's preparation does not produce allergic phenomena.
Long term toxicity test
Cavia porcellus continuous use 60 days; The result: gel of the present invention all has no significant effect indexs such as the hair of Cavia porcellus, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat.Histological examination shows, medication 60 days and after 2 weeks of drug withdrawal, and each internal organs of Cavia porcellus are all without obvious Histological change.Respectively organize Cavia porcellus during the medication and after the drug withdrawal all without unusually showing, behavior is active, ingests normally, and defecation is without unusually.The gel of the present invention's preparation is described without long term toxicity, application safety.
(2),In order to prove that preparation of the present invention has effective effect, carried out the clinical verification test, specific as follows:
The rheumatic arthritis diagnostic criteria:
Cardinal symptom:
Multi-joint migration pain, arthralgia, joint motion is ineffective when heavy; Pain and climate change have obvious relation, and be cold or increase the weight of when touching ice cold water, and weather alleviates when fine or warm.
Curative effect determinate standard:
The recovery from illness: clinical symptoms, sign disappears substantially, does not affect activity and work, joint motion freely, functional rehabilitation;
Produce effects: clinical symptoms, sign is obviously improved, and only mild occurs in tired situation, and functional rehabilitation does not affect work, or the state of an illness is transferred to slightly by severe;
Effectively: clinical symptoms, sign has the improvement of alleviating, but unstable condition, the time recurrence is arranged, but do not increase the weight of, the counterweight physical work is influential; Invalid: as not reach effective standard.
Therapeutic scheme:
Get medicine of the present invention and directly smear in right amount the affected part, every day 3～5 times (cooperate treating winter disease in summer effect of the present invention better).
The statistics curative effect:
Treatment rheumatic arthritis curative effect statistical table
| Sum | Cure in 30 days | Cured in 31-60 days | Cured in 61-90 days | Effective percentage | |
| The male | 144 | 76 | 54 | 13 | 99.3% |
| The women | 216 | 104 | 83 | 27 | 99.1% |
| Add up to | 360 | 180 | 137 | 40 | 99.2% |
To 360 rheumatic arthritis patients medication, wherein, 144 of male, 216 of women, 180 examples of curing in month, 137 examples of curing in two months, 40 examples of curing in three months, total effective rate reaches more than 99.2%.
The present invention has following application advantage:
1) medicine easily absorbs, and contains large quantity of moisture in the aqueous gel of the present invention, easily makes keratodermatitis softening, is conducive to the absorption of medicine, rapidly pain relieving, dispersing wind and cold;
2) little to skin irritation, easy to use, belong to skin-friendly type preparation, the present invention compares with traditional patch, used adjuvant is mainly the compositions such as carbomer, glycerol, propylene glycol, water, and is to the skin nonirritant, better with the coupling of skin, easily be coated with exhibition, easily washing is easy to use, can use according to the needs massage of indication, be conducive to the treatment of disease, also can be used for treating winter disease in summer.
Claims (4)
1. exterior-applied gel for the treatment of rheumatic arthritis, it is characterized in that, this gel is by weighing scale: Chinese medicine extraction extractum 100～220g, carbomer 25～50g, glycerol 15～55g, propylene glycol 80～260g, Flos Caryophylli volatile oil 5～10g, disodiumedetate 0.10～0.25g, ethyl hydroxybenzoate 1～2g, Borneolum Syntheticum 15～30g, Camphora 10～15g, Mentholum 15～30g, volumetric concentration is that 95% ethanol 200～400g and water 450～800g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by per 5～10g Flos Caryophylli, collects volatile oil, namely gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 5～10g, Fructus Capsici 10～20g, Rhizoma Chuanxiong 15～20g, Radix Saposhnikoviae 15～20g, the Flos Caryophylli medicinal residues that Radix Notoginseng 10～15g and per 5～10g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and per 5～10g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
2. the exterior-applied gel for the treatment of rheumatic arthritis according to claim 1, it is characterized in that, this gel is by weighing scale: Chinese medicine extraction extractum 100g, carbomer 50g, glycerol 15g, propylene glycol 260g, Flos Caryophylli volatile oil 10g, disodiumedetate 0.10g, ethyl hydroxybenzoate 1g, Borneolum Syntheticum 30g, Camphora 10g, Mentholum 30g, volumetric concentration is that 95% ethanol 200g and water 450g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by every 5g Flos Caryophylli, collects volatile oil, gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 10g, Fructus Capsici 10g, Rhizoma Chuanxiong 20g, Radix Saposhnikoviae 15g, the Flos Caryophylli medicinal residues that Radix Notoginseng 15g and every 5g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and every 5g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
3. the exterior-applied gel for the treatment of rheumatic arthritis according to claim 1, it is characterized in that, this gel is by weighing scale: Chinese medicine extraction extractum 160g, carbomer 33g, glycerol 35g, propylene glycol 170g, Flos Caryophylli volatile oil 8g, disodiumedetate 0.18g, ethyl hydroxybenzoate 1.5g, Borneolum Syntheticum 22g, Camphora 12g, Mentholum 23g, volumetric concentration is that 95% ethanol 300g and water 630g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by every 8g Flos Caryophylli, collects volatile oil, gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 8g, Fructus Capsici 15g, Rhizoma Chuanxiong 18g, Radix Saposhnikoviae 18g, the Flos Caryophylli medicinal residues that Radix Notoginseng 12g and every 8g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and every 8g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
4. the exterior-applied gel for the treatment of rheumatic arthritis according to claim 1, it is characterized in that, this gel is by weighing scale: Chinese medicine extraction extractum 220g, carbomer 25g, glycerol 55g, propylene glycol 80g, Flos Caryophylli volatile oil 5g, disodiumedetate 0.25g, ethyl hydroxybenzoate 2g, Borneolum Syntheticum 15g, Camphora 15g, Mentholum 15g, volumetric concentration is that 95% ethanol 400g and water 800g make, wherein, after getting disodiumedetate and adding a part of water dissolution, add again carbomer, stir evenly, leave standstill, get carbomer gel, for subsequent use; It is in 95% the ethanol that glycerol, propylene glycol, ethyl hydroxybenzoate, Borneolum Syntheticum, Camphora, Mentholum, Flos Caryophylli volatile oil and Chinese medicine extraction extractum are added volumetric concentration, stirs, and gets admixing medical solutions, for subsequent use; Admixing medical solutions is mixed with carbomer gel, add remaining water, stir, and get final product; Described Flos Caryophylli volatile oil is the water distillation 5 hours that is added its 6 times of weight by every 10g Flos Caryophylli, collects volatile oil, gets Flos Caryophylli volatile oil, and the Flos Caryophylli medicinal residues are for subsequent use; Described Chinese medicine extraction extractum is by weighing scale: Radix Aconiti Preparata 5g, Fructus Capsici 20g, Rhizoma Chuanxiong 15g, Radix Saposhnikoviae 20g, the Flos Caryophylli medicinal residues that Radix Notoginseng 10g and every 10g Flos Caryophylli are extracted behind the volatile oil are made, with Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, the Flos Caryophylli medicinal residues that Radix Notoginseng and every 10g Flos Caryophylli are extracted behind the volatile oil mix, add Radix Aconiti Preparata, Fructus Capsici, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Notoginseng, the volumetric concentration of 6～8 times of weight of Flos Caryophylli is 70～95% ethanol, heating and refluxing extraction 3 times, filter merging filtrate, decompression recycling ethanol, in the time of 50 ℃, be evaporated to relative density and be 1.10～1.25 Chinese medicine extraction extractum.
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| CN106190044A (en) * | 2015-05-04 | 2016-12-07 | 镇江市正源塑胶有限公司 | A kind of water warming blanket energy liquid containing orange blossom composition |
| CN106190043A (en) * | 2015-05-04 | 2016-12-07 | 镇江市正源塑胶有限公司 | A kind of water warming blanket energy liquid containing lavandula angustifolia composition |
| CN106336856A (en) * | 2015-07-13 | 2017-01-18 | 镇江市正源塑胶有限公司 | Sweet osmanthus component-containing liquid energy for water-heating blanket |
| CN105943885A (en) * | 2016-05-19 | 2016-09-21 | 庹朝彦 | External-use health liquid used for easing muscular and bone pain |
| CN106166290A (en) * | 2016-09-20 | 2016-11-30 | 刘富岗 | A kind of Chinese herbs paste treating infantile pneumonia |
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