CN106165792A - A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage and preparation processing method - Google Patents
A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage and preparation processing method Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of liver heat removing to relieve dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, be made up of the raw material of following weight portion: new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Spica Prunellae 5-15 part, Radix Achyranthis Bidentatae 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, unpeeled CORTEX MOUTAN 5-15 part, Ramulus Uncariae macrophyllae 5-10 part, Fructus Tribuli 5-15 part, Haematitum 5-12 part, Fructus Aristolochiae 5-15 part, Semen Sesami Nigrum 5-16 part, Radix Angelicae Sinensis 5-10 part, Folium Mori 5-15 part, Radix Polygoni Multiflori 5-15 part, Mel, water are appropriate.The invention have the advantage that inventive formulation have liver heat removing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., the function such as promoting blood circulation to remove blood stasis, carry and drink conveniently, improve body immunity, defying age, eliminating toxin and beautifying the skin, cure the disease strengthens the beverage of body immunity simultaneously, and the shelf-life is up to 1-2.
Description
Technical field
The present invention relates to a kind of liver heat removing relieve dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, in particular, relate to a kind of liver heat removing and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis drink formula and preparation method thereof technical field.
Background technology
The most traditional beverage, only focus on mouthfeel, it is of low nutritive value, do not have liver heat removing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., promoting blood circulation to remove blood stasis, the symptoms such as preventing and treating Liver Channel intenseness of heat, stagnation of turbid phlegm in middle-JIAO, hypertension, tinnitus, metal fatigue, dizzy cardiopalmus, loss of appetite, food stagnation do not disappear, anorexia, middle gas not province, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the function of the aspect such as anticancer, the sufferings of client cannot be released, and traditional herbal tea passes through Traditional medicine infusion, flavour of a drug weight mouthfeel is poor, it is impossible to preserve for a long time.The most not yet occur a kind of in good taste, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the beverage of body immunity simultaneously.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide a kind of fresh juice beverage to regulate the effect of human physiological functions, this beverage have be easily absorbed by the human body, medicinal function is notable, delicious flavour, good mouthfeel, improve self and increase the wriggling of the intestines and stomach, curing the disease strengthens a kind of liver heat removing of the advantages such as body immunity simultaneously and relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage.
A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, is made up of the raw material of following weight portion: new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Spica Prunellae 5-15 part, Radix Achyranthis Bidentatae 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, unpeeled CORTEX MOUTAN 5-15 part, Ramulus Uncariae macrophyllae 5-10 part, Fructus Tribuli 5-15 part, Haematitum 5-12 part, Fructus Aristolochiae 5-15 part, Semen Sesami Nigrum 5-16 part, Radix Angelicae Sinensis 5-10 part, Folium Mori 5-15 part, Radix Polygoni Multiflori 5-15 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, Mel, water are appropriate；
Described a kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. the preparation processing method of promoting blood circulation to remove blood stasis beverage, comprises the following steps；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, further take out and put into rotating centrifugal juice extractor, carry out three times to squeeze the juice, adding the Chinese liquor of alcohol content 52-60 DEG C of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time, time 10-15min, the rotating speed of juice extractor is 20～30r/s；After standing 10 minutes, adding the distilled water of Herba Dendrobii fresh bar weight 2-3 times, juice extractor time 10-15min for the second time, juice extractor rotating speed is 80～100r/s, stands 10min；After carry out third time squeeze the juice, add the distilled water of Herba Dendrobii fresh bar weight 3-5 times, time 20-30min, juice extractor rotating speed is 100～150r/s, fresh for Herba Dendrobii bar juice is separated with fiber filter, the fiber separation rate making the fresh bar of Herba Dendrobii reaches more than 95%, and broken cell rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；Again new fresh grape is put into after the warm water of 50-60 DEG C cleans up, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by；
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 degree, carry out infusion 10 minutes, obtain Matrix Solution I standby in tank；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, add in hermetically sealed can and be equivalent to Herba Dendrobii fresh bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, seal at a temperature of 30-35 DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby；Extract the Pericarpium Vitis viniferae after Matrix Solution and Herba Dendrobii fresh bar fiber addition mass volume ratio is the cellulase of 0.5-0.7%, add the water of the mass ratio of 1:10, keep 35 DEG C, water soluble dietary fiber can be extracted after 24h enzymolysis further, water soluble dietary fiber is added Matrix Solution and obtains Matrix Solution II；
E, take Spica Prunellae, after Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, unpeeled CORTEX MOUTAN, Ramulus Uncariae macrophyllae, Fructus Tribuli, Haematitum, Fructus Aristolochiae, Semen Sesami Nigrum, Radix Angelicae Sinensis, Folium Mori, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser mix homogeneously add 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer,-10～-20 DEG C freezing 10-20 minute, form freezing medicine block, freezing medicine block boiling is extracted 3 times, adding 1-2 times amount water for the first time, temperature keeps 100-120 DEG C, carries out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 6-10 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, is concentrated into the 1/2 of original volume, obtains Matrix Solution III standby；
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II and put into material-compound tank after the fine filter filter that mesh number is 100 mesh；Take Matrix Solution III again and put into material-compound tank after the fine filter filter that mesh number is 60 mesh；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, and packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, vanning.
Further: step B) in, after new fresh grape cleans up, put into reach in freezer ,-10～-20 DEG C freezing 5-10 minute, make Fructus Vitis viniferae freeze, take out after nature thaws, then carry out Fructus Vitis viniferae meat and Pericarpium Vitis viniferae detached job.
Further: step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae be 10:0.2～0.8:5～10:0.5.
Radix Salviae Miltiorrhizae, has blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, and clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.
Radix Achyranthis Bidentatae, dissipating blood stasis blood, subduing inflammation are used in life.
Radix Angelicae Sinensis, sweet, pungent, warm, return liver, the heart, spleen channel, enrich blood；Invigorate blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.
Spica Prunellae, liver heat removing, eliminating stagnation, diuresis.
Unpeeled CORTEX MOUTAN, pungent, bitter, be slightly cold.GUIXIN, liver, kidney channel.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, there is clearing away heat and cooling blood effect.
Ramulus Uncariae macrophyllae, sweet in the mouth, micro-hardship, cold nature；Return liver, pericardium channel；The latent fall of matter heavily fortified point, has heat clearing away suppressing the hyperactive liver, effect of relieving spasm by subduing liver-wind.
Fructus Tribuli, suppressing the hyperactive liver;Resolving depression;Dispelling pathogenic wind for improving eyesight.
Haematitum, has serious symptom sending down the abnormal ascending QI, suppressing the hyperactive liver and subsiding YANG, effect of cooling blood for hemostasis.
Fructus Aristolochiae, lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, bowel relieving disappear effects of hemorrhoid.
Semen Sesami Nigrum, has effects such as " invigorating the liver and kidney, grow the five internal organs, benefiting essence-blood, and intestine moistening is dry ".
Folium Mori, dispelling wind and heat pathogens;Lung heat clearing;Improving eyesight.
Radix Polygoni Multiflori, tonification essence and blood, crow beard and hair, bone and muscle strengthening, invigorating the liver and kidney.
Wherein, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, there is extension blood vessel to reduce blood pressure, Radix Achyranthis Bidentatae dissipating blood stasis system pain, conducting blood to flow downwards, head can be reduced congested, and liver and kidney tonifying；The main blood pressure lowering of the Fructus Aristolochiae liver heat removing therapeutic method to keep the adverse QI flowing downwards improves symptom.
The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, have liver heat removing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., effect of promoting blood circulation to remove blood stasis, there is Liver Channel intenseness of heat, stagnation of turbid phlegm in middle-JIAO, hypertension, tinnitus, metal fatigue, dizzy cardiopalmus, the merit of loss of appetite.The proportioning of each component is screened by great many of experiments, scientific and reasonable；And whole preparation technology is rationally and extract drugs rate efficiency is high, can retain the effective ingredient in raw material well, not bring any impurity, and sweet mouthfeel into, have no side effect.
The invention has the beneficial effects as follows:
1, the formula of the present invention, there is promoting the production of body fluid to quench thirst, gastric acid secretion, help digest, health body-building, there is calm nerves weak, lessen fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., to improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulates human physiological functions.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, lax blood vessel, increases systemic blood circulation, have certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, mutation, alleviate the function such as hepatosis, protection cardiovascular；
3, add the Chinese herbal medicine such as Spica Prunellae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, unpeeled CORTEX MOUTAN, Ramulus Uncariae macrophyllae, Fructus Tribuli, Haematitum, Fructus Aristolochiae, Semen Sesami Nigrum, Radix Angelicae Sinensis, Folium Mori, Radix Polygoni Multiflori have liver heat removing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., the function such as promoting blood circulation to remove blood stasis.
4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, there is the highest health care and medical value, long-term drink can be with YIN nourishing skin care, change skin colour, defying age, life lengthening, and carry and drink conveniently, improving self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the beverage of body immunity simultaneously, the shelf-life is up to 1-2.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention.
Embodiment 1
A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, is made up of the raw material of following weight portion: new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Spica Prunellae 10 parts, Radix Achyranthis Bidentatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, unpeeled CORTEX MOUTAN 10 parts, Ramulus Uncariae macrophyllae 10 parts, Fructus Tribuli 10 parts, Haematitum 10 parts, Fructus Aristolochiae 10 parts, Semen Sesami Nigrum 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts of Folium Mori, Radix Polygoni Multiflori 10 parts, 5 parts of Air Bladder pseudosciaenae seu Acipenser, Mel, water are appropriate；
A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. the preparation processing method of promoting blood circulation to remove blood stasis beverage, and described preparation method comprises the following steps；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
Fresh for the Herba Dendrobii cleaned up bar is put into microwave oven by B, keep temperature 50-60 DEG C, carry out heating 10 minutes, further take out and put into rotating centrifugal juice extractor, carry out three times to squeeze the juice, adding the Chinese liquor of the alcohol content 52 DEG C of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time, time 15min, the rotating speed of juice extractor is 30r/s；After standing 10 minutes, adding the distilled water of Herba Dendrobii fresh bar weight 2.5 times, juice extractor time 15min for the second time, juice extractor rotating speed is 80r/s, stands 10min；After carry out third time squeeze the juice, add the distilled water of Herba Dendrobii fresh bar weight 3-5 times, time 30min, juice extractor rotating speed is 150r/s, fresh for Herba Dendrobii bar juice is separated with fiber filter, the fiber separation rate making the fresh bar of Herba Dendrobii reaches more than 95%, and broken cell rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；Again new fresh grape is put into after the warm water of 55 DEG C cleans up, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by；After new fresh grape cleans up, put into reach in freezer ,-10 ~-20 DEG C of freezings 10 minutes, make Fructus Vitis viniferae freeze, after taking out nature defrosting, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 120 degree, carry out infusion 10 minutes, obtain Matrix Solution I standby in tank；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, add in hermetically sealed can and be equivalent to Herba Dendrobii fresh bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 6 times of weight, stirring is smashed to 100 mesh, seal at a temperature of 30-35 DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby；Extract the Pericarpium Vitis viniferae after Matrix Solution and Herba Dendrobii fresh bar fiber addition mass volume ratio is the cellulase of 0.5-0.7%, add the water of the mass ratio of 1:10, keep 35 DEG C, water soluble dietary fiber can be extracted after 24h enzymolysis further, water soluble dietary fiber is added Matrix Solution and obtains Matrix Solution II；；Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to strengthen blood vessel elasticity, lax blood vessel, increase systemic blood circulation, there is certain blood pressure reduction effect；Immune system ability can be strengthened; there is strong anti-oxidation, mutation, alleviate the function such as hepatosis, protection cardiovascular; stir to smash together with Pericarpium Vitis viniferae bar fresh with Herba Dendrobii fiber and mention anthocyanidin through hydromel, while farthest extracting anthocyanidin, can protect the quality of anthocyanidin.Water soluble dietary fiber is added Matrix Solution and obtains Matrix Solution II, effect of the wriggling of the intestines and stomach can be increased, it is ensured that metabolic waste normally excretes；Adsorb various metabolic waste, be allowed to normally excrete, improve the comprehensive utilization value of Herba Dendrobii.
E, take Spica Prunellae, after Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, unpeeled CORTEX MOUTAN, Ramulus Uncariae macrophyllae, Fructus Tribuli, Haematitum, Fructus Aristolochiae, Semen Sesami Nigrum, Radix Angelicae Sinensis, Folium Mori, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser mix homogeneously add 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer,-10～-20 DEG C of freezings 20 minutes, form freezing medicine block, freezing medicine block boiling is extracted 3 times, adding 1-2 times amount water for the first time, temperature keeps 100-120 DEG C, carries out infusion 10-20 minute；Second time adds 6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 6-10 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, is concentrated into the 1/2 of original volume, obtains Matrix Solution III standby；Chinese medicine foamed good after after freezing, cell wall crystallization ruptures, and forms freezing medicine block, then makes the composition of Chinese medicine farthest extract through high temperature infusion.
F, take Matrix Solution I through instantaneous high-temperature 120 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II and put into material-compound tank after the fine filter filter that mesh number is 100 mesh；Take Matrix Solution III again and put into material-compound tank after the fine filter filter that mesh number is 60 mesh；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；Supercritical extraction can extract under room temperature 37 DEG C and CO2 gas blanket, effectively prevent oxidation and the loss of heat-sensitive substance.Therefore, extract remains the effective ingredient of medicinal plants, and high boiling point, low volatility, the material of easily pyrolysis can be extracted under far below its boiling temperature；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, and described material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae are 10:0.5:6:0.5., sealing through bottle capper and load in vial, packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, vanning, carries and drinks conveniently, and the shelf-life is up to 1-2.
Embodiment 2
A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, is made up of the raw material of following weight portion: be made up of the raw material of following weight portion: be made up of the raw material of following weight portion: new fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Spica Prunellae 5 parts, Radix Achyranthis Bidentatae 5 parts, Radix Salviae Miltiorrhizae 5 parts, unpeeled CORTEX MOUTAN 5 parts, Ramulus Uncariae macrophyllae 5 parts, Fructus Tribuli 5 parts, Haematitum 5 parts, Fructus Aristolochiae 5 parts, Semen Sesami Nigrum 5 parts, Radix Angelicae Sinensis 5 parts, 5 parts of Folium Mori, Radix Polygoni Multiflori 5 parts, 5 parts of Air Bladder pseudosciaenae seu Acipenser, Mel, water are appropriate；Processing method is with embodiment 1.
Embodiment 3
A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, is made up of the raw material of following weight portion: be made up of the raw material of following weight portion: new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Spica Prunellae 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Salviae Miltiorrhizae 15 parts, unpeeled CORTEX MOUTAN 15 parts, Ramulus Uncariae macrophyllae 10 parts, Fructus Tribuli 15 parts, Haematitum 12 parts, Fructus Aristolochiae 15 parts, Semen Sesami Nigrum 16 parts, Radix Angelicae Sinensis 10 parts, 15 parts of Folium Mori, Radix Polygoni Multiflori 15 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, Mel, water are appropriate；Processing method is with embodiment 1.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 medicated tea add the medicated tea powder paste that rice flour is made.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By three kinds of each 50g of medicated tea, add rice flour.Experiment mice is randomly divided into three groups of male and female half and half, and three kinds of medicated tea powder of feeding are stuck with paste respectively, volume 1ml/10g
Body weight, close observation 8 hours is also noted down, and continues to observe 7 days；In 7 days, mice is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirt, and without fainting from fear addicted to saliva, eye, mouth, nose, ear and crissum secretions without exception, without the rotten toe that docks.Selecting 5 execution, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus respectively from three groups, no abnormality seen changes, shows that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 gained medicated tea add the medicated tea powder paste that rice flour is made.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that three kinds of medicated tea powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100,50g；Experimental mouse is randomly divided into three groups, the medicated tea powder that feeding modulates continuously respectively is stuck with paste, feeding 40 days continuously, observe animal general toxic reaction and the order of severity, place after death checks each position by rule of operation, and carries out the pathological examination of the main organs such as hematology, ALT, BUN and the heart, liver, spleen, lung, kidney, stomach；
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The most significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, it is understood that through proved by pathology, three kinds of medicated tea powder are stuck with paste and are showed animal without chronic toxicity.
By two above toxicity test, it was demonstrated that the medicated tea that the present invention is made by embodiment 1, embodiment 2 and embodiment 3 is safe, has no side effect, can be used to clinical patients is carried out clinical trial.
3, the embodiment of the present invention drinks effect research:
(1) investigation method:
1. crowd is drunk: general population
2. Ganderwa: 30 days
3. number is drunk: 50 people
4. drinking method: 3 times for each person every day, each 500mL
5. index:: after drinking substantially sensation easily fatigue, Liver Channel intenseness of heat, stagnation of turbid phlegm in middle-JIAO, hypertension, tinnitus, metal fatigue, dizziness cardiopalmus, loss of appetite, food stagnation do not disappear, anorexia, the transference cure such as middle gas not province, and mouthfeel is the most sour-sweet for effective；Sensation easily fatigue, Liver Channel intenseness of heat, stagnation of turbid phlegm in middle-JIAO, hypertension, tinnitus, metal fatigue, dizzy cardiopalmus, loss of appetite after drinking；Food stagnation does not disappears, anorexia, middle gas do not save remission, and mouthfeel is the most sour-sweet, is designated as effectively.It is invalid to be then designated as without obvious comfort after drinking.
(2) survey result
Survey result is shown in Table 1.Be test result indicate that by table 1, embodiment 1,2,3 have the respondent of 98% to feel beverage mouthfeel provided by the present invention is the most sour-sweet, and above-mentioned clinical symptom disappearance or be eased, the respondent of only 2% drink after without substantially increasing comfort.
The each embodiment of table 1 drinks effect research table
| Group/ Effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Embodiment 1 | 44%(22) | 54%(27) | 2%(1) |
| Embodiment 2 | 42%(21) | 56%(28) | 2%(1) |
| Embodiment 3 | 42%(21) | 56%(28) | 2%(1) |
Embodiment contrast groups A
Comparative example 4,5,6 is added without the nutritional labelings such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae, and according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing is traditional boiling method；The investigation method of using method and using effect is with above.
Table 2 embodiment contrast groups A drinks effect research
| Group/ Effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Comparative example 4 | 36%(18) | 40%(20) | 24%(12) |
| Comparative example 5 | 40%(20) | 40%(20) | 20%(10) |
| Comparative example 6 | 46%(23) | 34%(17) | 20%(10) |
Embodiment contrast groups B
Comparative example 7,8,9 is added without the nutritional labelings such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing uses the preparation processing method of step E in embodiment 1；The investigation method of using method and using effect is with above.
Table 3 embodiment contrast groups B drinks effect research
| Group/ Effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Comparative example 7 | 32%(16) | 56%(28) | 12%(6) |
| Comparative example 8 | 28%(14) | 52%(31) | 10%(5) |
Embodiment contrast groups C
The processing method of the most corresponding embodiment 1,2,3 of comparative example 10,11,12 and formula, different is that formula is interior without Air Bladder pseudosciaenae seu Acipenser composition；The investigation method of using method and using effect is with above.
Table 4 embodiment contrast groups C drinks effect research
| Group/ Effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Comparative example 10 | 44%(22) | 46%(23) | 10%(5) |
| Comparative example 11 | 38%(19) | 50%(25) | 12%(6) |
| Comparative example 12 | 40%(20) | 48%(24) | 12%(6) |
Conclusion:
Contrasted by table 2 and table 1 and can be seen that
The inefficient number of embodiment contrast groups A is about 10 times of embodiment 1,2,3；This shows to create the most collaborative pharmacological action between Chinese crude drug formula of the present invention and the nutritional labeling such as water soluble dietary fiber and Oleum Vitis viniferae; water soluble dietary fiber increases effect of the wriggling of the intestines and stomach and promotes the human body absorption to ingredient; ensure that metabolic waste normally excretes; the anthocyanidin that additionally contains in Pericarpium Vitis viniferae, resveratrol; there is strong anti-oxidation, mutation, alleviate the function such as hepatosis, protection cardiovascular, strengthen immune system ability；Associating with Chinese medicine and improve assimilation effect and improve the mouthfeel of Chinese medicine simultaneously, through the configuration meticulously of the present invention and the extraction of at utmost ingredient, Chinese crude drug formula of the present invention and preparation method occur in that beat all technique effect.
Table 2 and table 3 contrast can be seen that
About inefficient number is embodiment contrast groups B 2 times of embodiment contrast groups A, embodiment contrast groups B has compared significant raising with embodiment contrast groups A of traditional boiling method at therapeutic effect, this shows that Chinese crude drug of the present invention has had significant raising through the preparation processing method of step E than traditional boiling method, the extraction degree of active ingredient.
Table 1 is compared with table 4:
The formula of embodiment contrast groups C does not contains Air Bladder pseudosciaenae seu Acipenser, and the invalid number of embodiment contrast groups C is about 5 times of embodiment 1,2,3；And effective percentage number has and has declined；Air Bladder pseudosciaenae seu Acipenser can strengthen gastrointestinal digestive and absorptive functions, improve appetite, be conducive to preventing and treating the diseases such as inappetence, anorexia, dyspepsia, abdominal distention, constipation, show Air Bladder pseudosciaenae seu Acipenser serve in formula collaborative and priming return through effect, Air Bladder pseudosciaenae seu Acipenser application effect achieves unexpected technique effect.
In sum, a kind of liver heat removing promoting blood circulation to remove blood stasis beverage that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. that the present invention provides has sour-sweet mouthfeel, there is the most again treatment easily fatigue, Liver Channel intenseness of heat, stagnation of turbid phlegm in middle-JIAO, hypertension, tinnitus, metal fatigue, dizzy cardiopalmus, loss of appetite, food stagnation does not disappears, anorexia, middle gas do not save merit simultaneously, raising body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful.And all raw materials is all from medicine-food two-purpose natural plants, have no side effect.
The above is only the preferred embodiment of the present invention; it should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (6)
1. a liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, it is characterized in that, be made up of the raw material of following weight portion: new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Spica Prunellae 5-15 part, Radix Achyranthis Bidentatae 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, unpeeled CORTEX MOUTAN 5-15 part, Ramulus Uncariae macrophyllae 5-10 part, Fructus Tribuli 5-15 part, Haematitum 5-12 part, Fructus Aristolochiae 5-15 part, Semen Sesami Nigrum 5-16 part, Radix Angelicae Sinensis 5-10 part, Folium Mori 5-15 part, Radix Polygoni Multiflori 5-15 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, Mel, water are appropriate；
Described a kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. the preparation processing method of promoting blood circulation to remove blood stasis beverage, comprises the following steps；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, further take out and put into rotating centrifugal juice extractor, carry out three times to squeeze the juice, adding the Chinese liquor of alcohol content 52-60 DEG C of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time, time 10-15min, the rotating speed of juice extractor is 20～30r/s；After standing 10 minutes, adding the distilled water of Herba Dendrobii fresh bar weight 2-3 times, juice extractor time 10-15min for the second time, juice extractor rotating speed is 80～100r/s, stands 10min；After carry out third time squeeze the juice, add the distilled water of Herba Dendrobii fresh bar weight 3-5 times, time 20-30min, juice extractor rotating speed is 100～150r/s, fresh for Herba Dendrobii bar juice is separated with fiber filter, the fiber separation rate making the fresh bar of Herba Dendrobii reaches more than 95%, and broken cell rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；Again new fresh grape is put into after the warm water of 50-60 DEG C cleans up, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by；
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 degree, carry out infusion 10 minutes, obtain Matrix Solution I standby in tank；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, add in hermetically sealed can and be equivalent to Herba Dendrobii fresh bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, seal at a temperature of 30-35 DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby；Extract the Pericarpium Vitis viniferae after Matrix Solution and Herba Dendrobii fresh bar fiber addition mass volume ratio is the cellulase of 0.5-0.7%, add the water of the mass ratio of 1:10, keep 35 DEG C, water soluble dietary fiber can be extracted after 24h enzymolysis further, water soluble dietary fiber is added Matrix Solution and obtains Matrix Solution II；
E, take Spica Prunellae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, unpeeled CORTEX MOUTAN, Ramulus Uncariae macrophyllae, Fructus Tribuli, Haematitum, Fructus Aristolochiae, Semen Sesami Nigrum, Radix Angelicae Sinensis, Folium Mori, Radix Polygoni Multiflori；After mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine block, freezing medicine block boiling is extracted 3 times, add 1-2 times amount water for the first time, temperature keeps 100-120 DEG C, carries out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 6-10 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, is concentrated into the 1/2 of original volume, obtains Matrix Solution III standby；
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II and put into material-compound tank after the fine filter filter that mesh number is 100 mesh；Take Matrix Solution III again and put into material-compound tank after the fine filter filter that mesh number is 60 mesh；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, and packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, vanning.
A kind of liver heat removing the most according to claim 1 relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, it is characterized in that, step B) in, after new fresh grape cleans up, put into reach in freezer ,-10～-20 DEG C freezing 5-10 minute, make Fructus Vitis viniferae freeze, after taking out nature defrosting, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
A kind of liver heat removing the most according to claim 1 relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, it is characterised in that step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae be 10:0.2～0.8:5～10:0.5.
A kind of liver heat removing the most according to claim 1 relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, it is characterized in that, be made up of the raw material of following weight portion: new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Spica Prunellae 10 parts, Radix Achyranthis Bidentatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, unpeeled CORTEX MOUTAN 10 parts, Ramulus Uncariae macrophyllae 10 parts, Fructus Tribuli 10 parts, Haematitum 10 parts, Fructus Aristolochiae 10 parts, Semen Sesami Nigrum 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts of Folium Mori, Radix Polygoni Multiflori 10 parts, 5 parts of Air Bladder pseudosciaenae seu Acipenser, Mel, water are appropriate.
A kind of liver heat removing the most according to claim 1 relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, it is characterized in that, be made up of the raw material of following weight portion: new fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Spica Prunellae 5 parts, Radix Achyranthis Bidentatae 5 parts, Radix Salviae Miltiorrhizae 5 parts, unpeeled CORTEX MOUTAN 5 parts, Ramulus Uncariae macrophyllae 5 parts, Fructus Tribuli 5 parts, Haematitum 5 parts, Fructus Aristolochiae 5 parts, Semen Sesami Nigrum 5 parts, Radix Angelicae Sinensis 5 parts, 5 parts of Folium Mori, Radix Polygoni Multiflori 5 parts, 5 parts of Air Bladder pseudosciaenae seu Acipenser, Mel, water are appropriate.
A kind of liver heat removing the most according to claim 1 relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage, it is characterized in that, be made up of the raw material of following weight portion: new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Spica Prunellae 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Salviae Miltiorrhizae 15 parts, unpeeled CORTEX MOUTAN 15 parts, Ramulus Uncariae macrophyllae 10 parts, Fructus Tribuli 15 parts, Haematitum 12 parts, Fructus Aristolochiae 15 parts, Semen Sesami Nigrum 16 parts, Radix Angelicae Sinensis 10 parts, 15 parts of Folium Mori, Radix Polygoni Multiflori 15 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, Mel, water are appropriate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610234302.4A CN106165792A (en) | 2016-04-17 | 2016-04-17 | A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage and preparation processing method |
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| CN201610234302.4A CN106165792A (en) | 2016-04-17 | 2016-04-17 | A kind of liver heat removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc. promoting blood circulation to remove blood stasis beverage and preparation processing method |
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| CN106165792A true CN106165792A (en) | 2016-11-30 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
Non-Patent Citations (2)
| Title |
|---|
| 宋芳等: "超临界二氧化碳萃取葡萄籽油及其脂肪酸的分析", 《中国食品工业》 * |
| 李文亮等: "《千家妙方 上册》", 31 July 1982, 战士出版社 * |
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Application publication date: 20161130 |