CN106164054B - 吩嗪介导剂 - Google Patents

吩嗪介导剂 Download PDF

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Publication number
CN106164054B
CN106164054B CN201580019437.2A CN201580019437A CN106164054B CN 106164054 B CN106164054 B CN 106164054B CN 201580019437 A CN201580019437 A CN 201580019437A CN 106164054 B CN106164054 B CN 106164054B
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CN
China
Prior art keywords
compound
analyte
salt
side chain
ethyl
Prior art date
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CN201580019437.2A
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English (en)
Chinese (zh)
Other versions
CN106164054A (zh
Inventor
D·海因德尔
C·诺特迈耶
P·格鲍尔
S·亨特杜瓦尔
K·A·鲍尔埃斯平多拉
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN106164054A publication Critical patent/CN106164054A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D21/00—Measuring or testing not otherwise provided for
    • G01D21/02—Measuring two or more variables by means not covered by a single other subclass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201580019437.2A 2014-04-14 2015-04-13 吩嗪介导剂 Active CN106164054B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14164571 2014-04-14
EP14164571.3 2014-04-14
PCT/EP2015/057933 WO2015158645A1 (en) 2014-04-14 2015-04-13 Phenazinium mediators

Publications (2)

Publication Number Publication Date
CN106164054A CN106164054A (zh) 2016-11-23
CN106164054B true CN106164054B (zh) 2019-05-07

Family

ID=50478330

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580019437.2A Active CN106164054B (zh) 2014-04-14 2015-04-13 吩嗪介导剂

Country Status (7)

Country Link
US (1) US9988358B2 (enExample)
EP (1) EP3131882B1 (enExample)
JP (1) JP6522003B2 (enExample)
KR (1) KR101896820B1 (enExample)
CN (1) CN106164054B (enExample)
CA (1) CA2945612C (enExample)
WO (1) WO2015158645A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3523639T3 (pl) 2016-10-05 2025-03-17 F. Hoffmann-La Roche Ag Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania
CN111936050A (zh) 2018-03-30 2020-11-13 普和希控股公司 使用吩嗪衍生物或含有吩嗪衍生物的高分子量氧化还原聚合物的传感器
JP7285332B2 (ja) * 2019-09-30 2023-06-01 Ｐｈｃホールディングス株式会社 高分子量レドックスポリマー及びそれを用いたバイオセンサ

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683198A (en) * 1983-11-22 1987-07-28 Toyo Jozo Kabushiki Kaisha Novel maltose dehydrogenase, process for its production, and analytical method using the same
WO2009118157A1 (en) * 2008-03-27 2009-10-01 Roche Diagnostics Gmbh Biosensor with improved analyte specificity

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3228542A1 (de) 1982-07-30 1984-02-02 Siemens AG, 1000 Berlin und 8000 München Verfahren zur bestimmung der konzentration elektrochemisch umsetzbarer stoffe
US5108564A (en) 1988-03-15 1992-04-28 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
US5054039A (en) 1990-08-30 1991-10-01 The United States Of America As Represented By The Secretary Of The Navy Digital calibration circuit employing composite sine wave signals
DE19629656A1 (de) 1996-07-23 1998-01-29 Boehringer Mannheim Gmbh Diagnostischer Testträger mit mehrschichtigem Testfeld und Verfahren zur Bestimmung von Analyt mit dessen Hilfe
US5801006A (en) 1997-02-04 1998-09-01 Specialty Assays, Inc. Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites
JP4070050B2 (ja) 1998-07-24 2008-04-02 テルモ株式会社 血糖値測定方法及び装置
US6380380B1 (en) 1999-01-04 2002-04-30 Specialty Assays, Inc. Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates
WO2002034919A1 (en) 2000-10-27 2002-05-02 Roche Diagnostics Gmbh Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase
US7867369B2 (en) 2003-06-20 2011-01-11 Roche Diagnostics Operations, Inc. Biosensor with multiple electrical functionalities
MXPA06001719A (es) 2003-08-11 2006-05-19 Codexis Inc Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados.
DE102005035461A1 (de) 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate
DE502006004037D1 (de) 2005-12-19 2009-07-30 Roche Diagnostics Gmbh Sandwichsensor zur ermittlung einer analytkonzentration
EP2093284A1 (de) 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
EP3838147B1 (en) 2012-06-29 2023-12-06 Roche Diabetes Care GmbH Sensor element for detecting an analyte in a body fluid
JP2014194411A (ja) * 2013-02-28 2014-10-09 Aisin Seiki Co Ltd 修飾電極、当該修飾電極の製造方法、当該修飾電極を備えるバイオ電池並びにバイオセンサー
CN111848578B (zh) * 2014-08-22 2023-10-31 豪夫迈·罗氏有限公司 氧化还原指示剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683198A (en) * 1983-11-22 1987-07-28 Toyo Jozo Kabushiki Kaisha Novel maltose dehydrogenase, process for its production, and analytical method using the same
WO2009118157A1 (en) * 2008-03-27 2009-10-01 Roche Diagnostics Gmbh Biosensor with improved analyte specificity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Synthesis and Properties of Acrylamide-Substituted Base Pair Specific Dyes for Deoxyribonucleic Acid Template Mediated Synthesis of Dye Polymers";H. Bttnemann等;《Biochemistry》;19811231;第20卷(第10期);第2864－2874页 *

Also Published As

Publication number Publication date
EP3131882A1 (en) 2017-02-22
KR20160132970A (ko) 2016-11-21
US9988358B2 (en) 2018-06-05
JP2017517480A (ja) 2017-06-29
CA2945612C (en) 2019-09-10
EP3131882B1 (en) 2020-07-15
KR101896820B1 (ko) 2018-09-07
JP6522003B2 (ja) 2019-05-29
US20170226068A1 (en) 2017-08-10
CA2945612A1 (en) 2015-10-22
CN106164054A (zh) 2016-11-23
WO2015158645A1 (en) 2015-10-22

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