CN106146508A - 优化的联合用药及其治疗癌症和自身免疫疾病的用途 - Google Patents

优化的联合用药及其治疗癌症和自身免疫疾病的用途 Download PDF

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Publication number
CN106146508A
CN106146508A CN201510119944.5A CN201510119944A CN106146508A CN 106146508 A CN106146508 A CN 106146508A CN 201510119944 A CN201510119944 A CN 201510119944A CN 106146508 A CN106146508 A CN 106146508A
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China
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compound
inhibitor
disease
pharmaceutical composition
tumor
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CN201510119944.5A
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Chinese (zh)
Inventor
何伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd
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ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd
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Application filed by ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd filed Critical ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority to CN201510119944.5A priority Critical patent/CN106146508A/zh
Priority to CA3191171A priority patent/CA3191171A1/en
Priority to CN201680017009.0A priority patent/CN107406454B/zh
Priority to JP2017549326A priority patent/JP7012534B2/ja
Priority to EA202092671A priority patent/EA202092671A1/ru
Priority to CA2980016A priority patent/CA2980016C/en
Priority to MX2017011836A priority patent/MX2017011836A/es
Priority to KR1020227026364A priority patent/KR20220110872A/ko
Priority to EA201792066A priority patent/EA037058B1/ru
Priority to KR1020177025465A priority patent/KR102428387B1/ko
Priority to PCT/CN2016/000149 priority patent/WO2016145935A1/zh
Priority to EP16764117.4A priority patent/EP3272752A4/en
Priority to AU2016232923A priority patent/AU2016232923B2/en
Priority to BR112017019790-1A priority patent/BR112017019790B1/pt
Priority to IL254435A priority patent/IL254435B2/en
Priority to CN202111303221.2A priority patent/CN114790209A/zh
Priority to CN202010319886.1A priority patent/CN111349099A/zh
Priority to US15/183,340 priority patent/US9717745B2/en
Publication of CN106146508A publication Critical patent/CN106146508A/zh
Priority to CA3027506A priority patent/CA3027506A1/en
Priority to AU2017286654A priority patent/AU2017286654A1/en
Priority to US15/628,143 priority patent/US10098900B2/en
Priority to US16/123,167 priority patent/US10537587B2/en
Priority to US16/123,203 priority patent/US10596183B2/en
Priority to IL263641A priority patent/IL263641A/en
Priority to US16/790,197 priority patent/US11369620B2/en
Priority to AU2020277128A priority patent/AU2020277128B2/en
Priority to JP2021173052A priority patent/JP2022003103A/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/00Antineoplastic agents
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    • A61P37/02Immunomodulators
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    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201510119944.5A 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途 Pending CN106146508A (zh)

Priority Applications (27)

Application Number Priority Date Filing Date Title
CN201510119944.5A CN106146508A (zh) 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途
IL254435A IL254435B2 (en) 2015-03-19 2016-03-18 COMBINATION OF BTK INHIBITOR, mTOR KINASE INHIBITOR AND IMMUNOMODULATORY DRUG AND USE THEREFOR TO TREAT LYMPHOID MALIGNANCY
BR112017019790-1A BR112017019790B1 (pt) 2015-03-19 2016-03-18 Uso de um inibidor bruton tirosina quinase (btk)
JP2017549326A JP7012534B2 (ja) 2015-03-19 2016-03-18 癌および自己免疫疾患を治療するための最適化された組合せ療法およびその使用
EA202092671A EA202092671A1 (ru) 2015-03-19 2016-03-18 Оптимизированная комбинированная терапия и ее применение для лечения злокачественной опухоли и аутоиммунного заболевания
CN202111303221.2A CN114790209A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
MX2017011836A MX2017011836A (es) 2015-03-19 2016-03-18 Terapia de combinacion optimizada y uso de la misma para tratar cancer y enfermedad autoinmunitaria.
KR1020227026364A KR20220110872A (ko) 2015-03-19 2016-03-18 암 및 자가면역 질환을 치료하기 위한 최적화된 조합 요법 및 그의 용도
EA201792066A EA037058B1 (ru) 2015-03-19 2016-03-18 Оптимизированная комбинированная терапия и ее применение для лечения злокачественной опухоли и аутоиммунного заболевания
KR1020177025465A KR102428387B1 (ko) 2015-03-19 2016-03-18 암 및 자가면역 질환을 치료하기 위한 최적화된 조합 요법 및 그의 용도
CN201680017009.0A CN107406454B (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
EP16764117.4A EP3272752A4 (en) 2015-03-19 2016-03-18 Optimised combination therapy and use thereof to treat cancer and autoimmune disease
AU2016232923A AU2016232923B2 (en) 2015-03-19 2016-03-18 Optimised combination therapy and use thereof to treat cancer and autoimmune disease
CA3191171A CA3191171A1 (en) 2015-03-19 2016-03-18 Optimized combination therapy and use thereof to treat cancer and autoimmune disease
PCT/CN2016/000149 WO2016145935A1 (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CA2980016A CA2980016C (en) 2015-03-19 2016-03-18 Optimized combination therapy and use thereof to treat cancer and autoimmune disease
CN202010319886.1A CN111349099A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
US15/183,340 US9717745B2 (en) 2015-03-19 2016-06-15 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
CA3027506A CA3027506A1 (en) 2015-03-19 2017-06-15 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
AU2017286654A AU2017286654A1 (en) 2015-03-19 2017-06-15 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
US15/628,143 US10098900B2 (en) 2015-03-19 2017-06-20 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
US16/123,203 US10596183B2 (en) 2015-03-19 2018-09-06 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
US16/123,167 US10537587B2 (en) 2015-03-19 2018-09-06 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
IL263641A IL263641A (en) 2015-03-19 2018-12-11 Pharmaceutical preparations and their use for the treatment of cancer and autoimmune diseases
US16/790,197 US11369620B2 (en) 2015-03-19 2020-02-13 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
AU2020277128A AU2020277128B2 (en) 2015-03-19 2020-11-24 Optimised combination therapy and use thereof to treat cancer and autoimmune disease
JP2021173052A JP2022003103A (ja) 2015-03-19 2021-10-22 癌および自己免疫疾患を治療するための最適化された組合せ療法およびその使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510119944.5A CN106146508A (zh) 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途

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CN106146508A true CN106146508A (zh) 2016-11-23

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN201510119944.5A Pending CN106146508A (zh) 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN202111303221.2A Pending CN114790209A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN201680017009.0A Active CN107406454B (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN202010319886.1A Pending CN111349099A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途

Family Applications After (3)

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CN202111303221.2A Pending CN114790209A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN201680017009.0A Active CN107406454B (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN202010319886.1A Pending CN111349099A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途

Country Status (11)

Country Link
EP (1) EP3272752A4 (https=)
JP (2) JP7012534B2 (https=)
KR (2) KR102428387B1 (https=)
CN (4) CN106146508A (https=)
AU (2) AU2016232923B2 (https=)
BR (1) BR112017019790B1 (https=)
CA (2) CA3191171A1 (https=)
EA (2) EA037058B1 (https=)
IL (1) IL254435B2 (https=)
MX (1) MX2017011836A (https=)
WO (1) WO2016145935A1 (https=)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106831788A (zh) * 2017-01-22 2017-06-13 鲁南制药集团股份有限公司 伊布替尼精制方法
CN108992454A (zh) * 2018-06-20 2018-12-14 合肥医工医药有限公司 一种治疗皮肤炎症性疾病的复方药物组合物
CN109475566A (zh) * 2016-06-15 2019-03-15 浙江导明医药科技有限公司 药物组合物及其用于治疗癌症和自身免疫疾病的用途
CN110724143A (zh) * 2019-10-09 2020-01-24 清华大学 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用
CN110845500A (zh) * 2019-10-09 2020-02-28 清华大学 靶向btk降解化合物在治疗自身免疫系统疾病中的应用
CN112165945A (zh) * 2017-10-27 2021-01-01 浙江导明医药科技有限公司 治疗淋巴样恶性疾病之方法
CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
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