CN106139046A - 一种治疗淋菌性尿道炎的中药组合物及其制备方法 - Google Patents
一种治疗淋菌性尿道炎的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及中医药领域,尤其涉及一种治疗淋菌性尿道炎的中药组合物。由苦参、甘草、枸杞、通草、灯心草、萹蓄、黄连、三七、金银花、蒲公英、决明子、益母草、虎杖、莪术、土荆皮、芦根、何首乌、玉竹、蛤蚧、肉苁蓉、黄芪、金莲花、香附、石菖蒲、白薇、红大戟、穿心莲、马齿苋等组成。本发明相对于现有技术具有疗效好、成本低、局限性小、无不良反应等优点。与同类药物比较,本发明药物具有配伍严谨,药性平和,疗效显著的特点,便于在临床上大面积推广应用。
Description
技术领域
本发明属于中药学技术领域,具体涉及一种治疗淋菌性尿道炎的中药组合物及其制备方法。
背景技术
尿道炎是指尿道因各种原因导致炎症,出现分泌物、尿痛或尿道不适等症状。如果能检出淋病奈瑟菌(简称淋球菌),称为淋菌性尿道炎;如果查不到淋病奈瑟菌,称为非淋菌性尿道炎。
非淋菌性尿道炎是有尿道炎存在,但尿道分泌物查不到淋球菌的一类疾病。主要是由衣原体和支原体引起,通过性交传染,侵犯泌尿生殖道器官,尤其是由于衣原体、支原体引起的前列腺炎睾丸炎,盆腔炎、附件炎更为多见。又因长期大量应用抗生素,极易导致患者体内衣原体支原体也不同程度的产生了耐药性,并且副作用比较大,从而影响了治疗效果。目前在治疗上多采用西药抗生素治疗为主。但由于抗生素的广泛应用,病原体的耐药性不断增加和毒副作用较大,疗效欠佳。
采用中医疗法,发挥中医辨证施治的特点,从而能更好的改善症状,治愈本病。因此急需寻找一种副作用小,远期疗效好,易于接受的治疗非淋菌性尿道炎的中药。
发明内容
为了克服现有技术中的不足,本发明提供一种治疗淋菌性尿道炎的中药组合物,对淋菌性尿道炎具有显著疗效。
为了解决上述技术问题,本发明采用的技术方案如下:一种治疗淋菌性尿道炎的中药组合物,由以下重量份数的各组分组成:
苦参0.5-15份、甘草2-10份、枸杞1-10份、通草1-5份、灯心草1-6份、萹蓄1-10份、黄连3-10份、三七1-5份、金银花1-4份、蒲公英1-6份、决明子2-8份、益母草2-10份、虎杖1-5份、莪术1-10份、土荆皮3-10份、芦根0.5-8份、何首乌1-4份、玉竹1-7份、蛤蚧1-8份、肉苁蓉3-18份、黄芪2-10份、金莲花2-8份、香附1-4份、石菖蒲1-5份、白薇1-3份、红大戟2-10份、穿心莲2-8份、马齿苋3-10份、厚朴1-4份、熟地黄2-10份、降香2-8份、皂角刺1-10份、马钱子2-8份、川炼子1-5份、冬葵果1-10份。
进一步的,本发明由以下重量份数的各组分组成:
苦参0.5-10份、甘草2-8份、枸杞1-8份、通草1-5份、灯心草1-3份、萹蓄1-10份、黄连3-8份、三七1-5份、金银花1-4份、蒲公英1-6份、决明子2-8份、益母草2-8份、虎杖1-5份、莪术1-8份、土荆皮3-10份、芦根0.5-8份、何首乌1-4份、玉竹1-5份、蛤蚧1-8份、肉苁蓉3-10份、黄芪2-10份、金莲花2-8份、香附1-4份、石菖蒲1-5份、白薇1-3份、红大戟2-10份、穿心莲2-8份、马齿苋3-10份、厚朴1-4份、熟地黄2-8份、降香2-5份、皂角刺1-8份、马钱子2-8份、川炼子1-5份、冬葵果1-8份。
进一步的,本发明由以下重量份数的各组分组成:
苦参0.5份、甘草4份、枸杞3份、通草1份、灯心草1份、萹蓄3份、黄连3份、三七2份、金银花3份、蒲公英3份、决明子2份、益母草4份、虎杖1份、莪术2份、土荆皮3份、芦根2份、何首乌2份、玉竹1份、蛤蚧1份、肉苁蓉3份、黄芪2份、金莲花3份、香附2份、石菖蒲1份、白薇1份、红大戟2份、穿心莲3份、马齿苋3份、厚朴1份、熟地黄2份、降香1份、皂角刺2份、马钱子3份、川炼子1份、冬葵果2份。
进一步的,本发明由以下重量份数的各组分组成:苦参0.5份、甘草6份、枸杞5份、通草1份、灯心草2份、萹蓄2份、黄连3份、三七2份、金银花4份、蒲公英4份、决明子3份、益母草2份、虎杖1份、莪术1份、土荆皮3份、芦根1份、何首乌2份、玉竹1份、蛤蚧2份、肉苁蓉3份、黄芪2份、金莲花3份、香附2份、石菖蒲1份、白薇1份、红大戟2份、穿心莲3份、马齿苋3份、厚朴1份、熟地黄2份、降香1份、皂角刺2份、马钱子3份、川炼子1份、冬葵果2份。
进一步的,本发明所述中药制剂的剂型为:汤剂、口服液、颗粒剂、散剂、胶囊剂、冲剂或片剂。
为了解决上述技术问题,本发明还提供一种治疗淋菌性尿道炎的中药组合物的制备方法,包括以下步骤:
(1)按处方取苦参、甘草、枸杞、通草、灯心草、萹蓄、黄连、三七、金银花、蒲公英、决明子、益母草、虎杖、莪术、土荆皮、芦根、何首乌、玉竹、蛤蚧、肉苁蓉、黄芪、金莲花、香附、石菖蒲、白薇、红大戟、穿心莲、马齿苋、厚朴、熟地黄、降香、皂角刺、马钱子、川炼子、冬葵果放入不锈钢锅内,加常温下的水,加水量没过中药上层面1厘米,浸泡150分钟,加热10分钟,过滤制得一次过滤药液,并留渣,将所得一次过滤药液放在暂存容器内暂存;再向盛有药渣的锅中倒入开水,加开水量没过药渣上层面1厘米,加热10分钟,过滤得二次过滤药液,并去渣,将两次得到的过滤药液混合。
(2)将步骤(1)得到的过滤混合药液减压蒸馏,浓缩得到膏体,干燥粉碎得到粉末。
(3)步骤(3)所得粉末与药物辅料制得相应的制剂。
为了解决上述技术问题,本发明还提供另一种治疗淋菌性尿道炎的中药组合物的制备方法,包括以下步骤:
包括以下步骤:取苦参、甘草、枸杞、通草、灯心草、萹蓄、黄连、三七、金银花、蒲公英、决明子、益母草、虎杖、莪术、土荆皮、芦根、何首乌、玉竹、蛤蚧、肉苁蓉、黄芪、金莲花、香附、石菖蒲、白薇、红大戟、穿心莲、马齿苋、厚朴、熟地黄、降香、皂角刺、马钱子、川炼子、冬葵果药材洗净、烘干粉碎药材加水煎煮两次,第一次加水5-10倍量,煮沸1-5小时;第二次加水4-8倍量,煮沸0.5-3小时,合并煎液,过滤,将滤液于55℃浓缩至比重为1.14-1.47,放出浓缩液,加水稀释,静置24小时,取上清液过300-400目滤网,浓缩,然后按常规制剂工艺分别制成相应的胶囊剂、丸剂、片剂、散剂、口服液或颗粒剂。
为了解决上述技术问题,本发明还提供另一种治疗淋菌性尿道炎的中药药酒的制备方法,包括以下步骤:
将上述的中药与黄酒同放在容器内封浸泡7天后,滤渣后即得药酒,或是将上述的中药与黄酒同煎成液体,滤渣后即得药酒。
本发明还包括治疗淋菌性尿道炎的中药组合物或所述的中药组合物与药学上可接受的药物载体在制备治疗淋菌性尿道炎的药物制剂中的应用。
本发明根据现代中药药理,又经过了多年的临床试验,不断摸索形成的一种治疗淋菌性尿道炎的中药。本发明是在传统的中医辩证施治的基础上结合临床实践研制而成,具有清热通淋、渗湿利尿,泻火解毒之功效,经过临床实践发现,对非淋菌性尿道炎具有独特的疗效。本发明药物根据辨病及辩证相结合的原则,与同类药物比较,具有配伍严谨,药性平和,疗效显著的特点,便于在临床上大面积推广应用。
具体实施方式
本申请请求保护的核心与关键是中药组合物的配伍,不在于剂型,凡是采用本中药组合物制成的任何剂型,均属于本发明请求保护的范围。其包含的原料组分是:苦参、甘草、枸杞、通草、灯心草、萹蓄、黄连、三七、金银花、蒲公英、决明子、益母草、虎杖、莪术、土荆皮、芦根、何首乌、玉竹、蛤蚧、肉苁蓉、黄芪、金莲花、香附、石菖蒲、白薇、红大戟、穿心莲、马齿苋、厚朴、熟地黄、降香、皂角刺、马钱子、川炼子、冬葵果。
其中,每一中药组分的主要成分及功效分别介绍如下:
苦参:性味:苦,寒。归经:归心、肝、胃、大肠、膀胱经。功能主治:清热燥湿,杀虫,利尿。用于热痢,便血,黄疸尿闭,赤白带下,阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风;外治滴虫性阴道炎。
甘草:性味:甘,平。归经:归心、肺、脾、胃经。功能主治:补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
枸杞子:性味:甘,平。归经:归肝、肾经。功能主治:滋补肝肾,益精明目。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,内热消渴,血虚萎黄,目昏不明。
通草:主治:湿温尿赤、淋病涩痛、水肿尿少、乳汁不下。
灯心草:性味:甘、淡,微寒。归经:归心、肺、小肠经。功能主治:清心火,利小便。用于心烦失眠,尿少涩痛,口舌生疮。
萹蓄:性味:苦,微寒。归经:归膀胱经。功能主治:利尿通淋,杀虫,止痒。用于膀胱热淋,小便短赤,淋沥涩痛,皮肤湿疹,阴痒带下。
黄连:性味:苦,寒。归经:归心、脾、胃、肝、胆、大肠经。功能主治:清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,血热吐衄,目赤,牙痛,消渴,痈肿疔疮;外治湿疹,湿疮,耳道流脓。酒黄连善清上焦火热。用于目赤,口疮。姜黄连清胃和胃止呕。用于寒热互结,湿热中阻,痞满呕吐。萸黄连舒肝和胃止呕。用于肝胃不和,呕吐吞酸。
三七:性味:甘、微苦,温。归经:归肝、胃经。功能主治:散瘀止血,消肿定痛。用于咯血,吐血,衄血,便血,崩漏,外伤出血,胸腹剌痛,跌扑肿痛。
金银花:性味:甘,寒。归经:归肺、心、胃经。功能主治:清热解毒,凉散风热。用于痈肿疔疮,喉痹,丹毒,热毒血痢,风热感冒,温病发热。
蒲公英:性味:苦、甘,寒。归经:归肝、胃经。功能主治:清热解毒,消肿散结,利尿通淋。用于疔疮肿毒,乳痈,瘰疠,目赤,咽痛,肺痈,肠痈,湿热黄疸,热淋涩痛。
决明子:性味:甘、苦、咸,微寒。归经:归肝、大肠经。功能主治:清热明目,润肠通便。用于目赤涩痛,羞明多泪,头痛眩晕,目暗不明,大便秘结。
益母草:性味:苦、辛,微寒。归经:归肝、心包经。功能主治:活血调经,利尿消肿。用于月经不调,痛经,经闭,恶露不尽,水肿尿少;急性肾炎水肿。
虎杖:性味:微苦,微寒。归经:归肝、胆、肺经。功能主治:祛风利湿,散瘀定痛,止咳化痰。用于关节痹痛,湿热黄疸,经闭,症瘕,水火烫伤,跌扑损伤,痈肿疮毒,咳嗽痰多。
莪术:性味:味辛;苦;性温。归经:归肝、脾经。功能主治:行气破血;消积止痛。主血气心痛;饮食积滞;脘腹胀痛;血滞经闭;痛经;症瘕瘤痞块;跌打损伤。
土荆皮:性味:辛,温;有毒。归经:归肺、脾经。功效:杀虫,止痒。主治:治疥癣瘙痒。
芦根:性味:甘,寒。归经:归肺、胃经。功能主治:清热生津,除烦,止呕,利尿。用于热病烦渴,胃热呕哕,肺热咳嗽,肺痈吐脓,热淋涩痛。
何首乌:性味:苦、甘、涩,温。归经:归肝、心、肾经。功能主治:解毒,消痈,润肠通便。用于瘰疠疮痈,风疹瘙痒,肠燥便秘;高血脂。
玉竹:性味:甘,微寒。归经:归肺、胃经。功能主治:养阴润燥,生津止渴。用于肺胃阴伤,燥热咳嗽,咽干口渴,内热消渴。
蛤蚧:性味:咸,平。归经:归肺、肾经。功能主治:补肺益肾,纳气定喘,助阳益精。用于虚喘气促,劳嗽咳血,阳萎遗精。
肉苁蓉:性味:味甘;咸;性温。归经:归肾;大肠经。功能主治:补肾阳;益精血;润肠道。主肾阳虚衰;精血不足之阳痿;遗精;白浊;尿频余沥;腰痛脚弱;耳鸣目花;月经衍期;宫寒不孕;肠燥便秘。
黄芪:性味:甘,温。归经:归肺、脾经。功能主治:补气固表,利尿托毒,排脓,敛疮生肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难溃,久溃不敛,血虚痿黄,内热消渴;慢性肾炎蛋白尿,糖尿病。
金莲花:性味:味苦;性微寒。归经:归肺;胃经。功能主治:清热解毒;消肿;明目。主主治感冒发热;咽喉肿痛;口疮;牙龈肿痛;牙龈出血;目赤肿痛;疔疮肿毒;急性鼓膜炎;急性淋巴管炎。
香附:性味:辛、微苦、微甘,平。归经:归肝、脾、三焦经。功能主治:行气解郁,调经止痛。用于肝郁气滞,胸、胁、脘腹胀痛,消化不良,胸脘痞闷,寒疝腹痛,乳房胀痛,月经不调,经闭痛经。
石菖蒲:性味:辛、苦,温。归经:归心、胃经。功能主治:化湿开胃,开窍豁痰,醒神益智。用于脘痞不饥,噤口下痢,神昏癫痫,健忘耳聋。
白薇:性味:苦咸,寒。归经:入肺、胃、肾经。功能主治:清热凉血,利尿通淋,解毒疗疮。用于温邪伤营发热,阴虚发热,骨蒸劳热,产后血虚发热,热淋,血淋,痈疽肿毒。刀伤。
红大戟:性味:苦,寒;有小毒。归经:归肺、脾、肾经。功能主治:泻水逐饮,功毒消肿散结。用于胸腹积水,二便不利,痈肿疮毒,瘰疬痰核。
穿心莲:性味:苦,寒。归经:归心、肺、大肠、膀胱经。功能主治:清热解毒,凉血,消肿。用于感冒发热,咽喉肿痛,口舌生疮,顿咳劳嗽,泄泻痢疾,热淋涩痛,痈肿疮疡,毒蛇咬伤。
马齿苋:性味:酸,寒。功能主治:清热利湿,凉血解毒。用于细菌性痢疾,急性胃肠炎,急性阑尾炎,乳腺炎,痔疮出血,白带;外用治疔疮肿毒,湿疹、带状疱疹。
厚朴:性味:苦、辛,温。归经:归脾、胃、肺、大肠经。功能主治:燥湿消痰,下气除满。用于湿滞伤中,脘痞吐泻,食积气滞,腹胀便秘,痰饮喘咳。
厚朴:性味:苦、辛,温。归经:归脾、胃、肺、大肠经。功能主治:燥湿消痰,下气除满。用于湿滞伤中,脘痞吐泻,食积气滞,腹胀便秘,痰饮喘咳。
熟地黄:性味:甘,微温。归经:归肝、肾经。功能主治:滋阴补血,益精填髓。用于肝肾阴虚,腰膝酸软,骨蒸潮热,盗汗遗精,内热消渴,血虚萎黄,心悸怔忡,月经不调,崩漏下血,眩晕,耳鸣,须发早白。
降香:性味:辛;温;无毒。归经:肝;脾;肺;心经。功能主治:活血散瘀,止血定痛,降气,辟秽。主胸胁疼痛,跌打损伤,创伤出血,以及寒疝疼痛或秽浊内阻之呕吐腹痛。
皂角刺:性味:辛,温。归经:归肝、胃经。功能主治:消肿托毒,排脓,杀虫。用于痈疽初起或脓成不溃;外治疥癣麻风。
马钱子:性味:苦,温;有大毒。归经:归肝、脾经。功能主治:通络止痛,散结消肿。用于风湿顽痹,麻木瘫痪,跌扑损伤,痈疽肿痛;小儿麻痹后遗症,类风湿性关节痛。
川炼子:性味:苦、寒;有小毒。归经:归肝、小肠、膀胱经。功能主治:疏肝泄热;行气止痛;杀虫。主脘腹胁肋疼痛;疝气疼痛;虫积腹痛;头癣。
冬葵果:性味:茎、叶:甘,寒。根:甘,温。功能主治:茎、叶:清热利湿;用于黄疸型肝炎。根:补中益气;用于气虚乏力,腰膝酸软,体虚自汗,脱肛,子宫脱垂,慢性肾炎,糖尿病。
下面结合具体实施例对本发明做进一步阐述。
实施例1
苦参0.5份、甘草4份、枸杞3份、通草1份、灯心草1份、萹蓄3份、黄连3份、三七2份、金银花3份、蒲公英3份、决明子2份、益母草4份、虎杖1份、莪术2份、土荆皮3份、芦根2份、何首乌2份、玉竹1份、蛤蚧1份、肉苁蓉3份、黄芪2份、金莲花3份、香附2份、石菖蒲1份、白薇1份、红大戟2份、穿心莲3份、马齿苋3份、厚朴1份、熟地黄2份、降香1份、皂角刺2份、马钱子3份、川炼子1份、冬葵果2份。
上述配方的制备:(1)按处方取苦参、甘草、枸杞、通草、灯心草、萹蓄、黄连、三七、金银花、蒲公英、决明子、益母草、虎杖、莪术、土荆皮、芦根、何首乌、玉竹、蛤蚧、肉苁蓉、黄芪、金莲花、香附、石菖蒲、白薇、红大戟、穿心莲、马齿苋、厚朴、熟地黄、降香、皂角刺、马钱子、川炼子、冬葵果放入不锈钢锅内,加常温下的水,加水量没过中药上层面1厘米,浸泡150分钟,加热10分钟,过滤制得一次过滤药液,并留渣,将所得一次过滤药液放在暂存容器内暂存;再向盛有药渣的锅中倒入开水,加开水量没过药渣上层面1厘米,加热10分钟,过滤得二次过滤药液,并去渣,将两次得到的过滤药液混合。
(2)将步骤(1)得到的过滤混合药液减压蒸馏,浓缩得到膏体,干燥粉碎得到粉末。
(3)步骤(2)所得粉末与胶囊辅料制得相应的胶囊剂。
实施例2
取苦参0.5份、甘草6份、枸杞5份、通草1份、灯心草2份、萹蓄2份、黄连3份、三七2份、金银花4份、蒲公英4份、决明子3份、益母草2份、虎杖1份、莪术1份、土荆皮3份、芦根1份、何首乌2份、玉竹1份、蛤蚧2份、肉苁蓉3份、黄芪2份、金莲花3份、香附2份、石菖蒲1份、白薇1份、红大戟2份、穿心莲3份、马齿苋3份、厚朴1份、熟地黄2份、降香1份、皂角刺2份、马钱子3份、川炼子1份、冬葵果2份药材洗净、烘干粉碎药材加水煎煮两次,第一次加水5-10倍量,煮沸1-5小时;第二次加水4-8倍量,煮沸0.5-3小时,合并煎液,过滤,将滤液于55℃浓缩至比重为1.14-1.47,放出浓缩液,加水稀释,静置24小时,取上清液过300-400目滤网,浓缩,然后按常规制剂工艺制成口服液。
实施例3
取苦参0.5份、甘草6份、枸杞5份、通草1份、灯心草2份、萹蓄2份、黄连3份、三七2份、金银花4份、蒲公英4份、决明子3份、益母草2份、虎杖1份、莪术1份、土荆皮3份、芦根1份、何首乌2份、玉竹1份、蛤蚧2份、肉苁蓉3份、黄芪2份、金莲花3份、香附2份、石菖蒲1份、白薇1份、红大戟2份、穿心莲3份、马齿苋3份、厚朴1份、熟地黄2份、降香1份、皂角刺2份、马钱子3份、川炼子1份、冬葵果2份与黄酒同放在容器内封浸泡7天后,滤渣后即得药酒。
毒性试验:
实验动物
小白鼠由青岛市实验动物和动物实验中心提供。
小白鼠灌胃给药急性毒性实验
应用小鼠进行急性毒性实验表明:小鼠口服灌胃本发明的中药制剂胶囊剂,在387.1g生药/kg剂量下,给药后小鼠出现轻微活动减少,1小时左右恢复正常,给药后连续观察7天,无一动物死亡,其全身状况、饮食、摄水、小便和体重增长均正常,实验结果表明:小鼠口服灌胃本发明的中药制剂胶囊剂的最大给药量为388.8g生药/kg/d(LD50>388.8g生药/kg)。本发明的中药制剂每日临床用药总量为0.1g生药/kg/d;按体重计,小鼠灌胃本发明的中药制剂的耐受量为临床病人的3888倍。提示该药急性毒性低,临床用药安全。
大鼠灌胃给药长期毒性实验
毒性试验:
选用SD大鼠,给予不同浓度(16.0、5.0、1.0g生药/kg)的本发明的中药制剂胶囊剂,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动物(雌雄各半),其余1/2动物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90天和停药2周进行血液学(RBC、HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、ALP、Glu、BUN、Crea、TP、T.BIL、ALB、CHOL)、尿液生化、脏器系数、病理组织学等指标检查。试验结果表明:本发明的中药制剂在高、中、低剂量组动物一般状态良好,外观体征、行为活动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的160、50、10倍,根据试验结果本发明的中药制剂在高、中、低三个剂量(16.0、5.0、1.0g生药/kg)连续90天给药对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应,提示本发明的中药制剂临床应用的剂量安全性较高。
临床资料。
(1)实验材料:
本发明人于2013年至今,对211例淋菌性尿道炎患者进行临床观察治疗,其中,男103例,女108例。对照组100人;实验组101人。
(2)、诊断标准
1、有不洁性接触史。2、潜伏期1~3周。3、常见的临床表现:男性患者常有浆液性或粘液脓性分泌物从尿道口流出或排尿疼痛。女性患者常有尿频及排尿困难。如波及宫颈时,表现为炎症和糜烂,分泌物增多,阴道及外防瘙痒,但也有些病人无症状。4、分泌物涂片和培养无淋菌者,分泌物涂片,革兰氏染色或展起首次(或尿后2~3小时)小便做离心沉淀,取沉淀物进行检查,高倍镜下每视野有10~15个以上多形核白细胞者,培养可检出衣原体或支原体。非淋菌性尿道炎是一种以衣原体和支原体为主要致病微生物导致的泌尿生殖系统感染,主要通过性接触传染,临床过程隐匿、迁延,临床表现轻微,常伴发上生殖道感染。
(3)、治疗方法
治疗方法:实验组:服用本发明中药实施例1的胶囊剂,每次3粒,每日3次,30天为一个疗程。对照组口服抗生素3个月,如大环内酯类。
(4)、治疗结果:
疗效判断标准:痊愈:症状全部消失;有效:症状明显减轻;无效:治疗前后无明显变化或恶化。
治疗结果:两组分别治疗1个疗程后,统计结果参见表1。从表1可以看出,采用本发明的中药治疗淋菌性尿道炎,相对于西药在治疗效果上,具有显著的改进。
表1两组分别治疗1个疗程后临床疗效比较例
分组 | 人数 | 治愈(n) | 有效 | 无效 | 总有效率 |
实验组 | 101 | 53 | 42 | 6 | 94% |
对照组 | 100 | 49 | 37 | 14 | 86% |
根据统计学理论,采用Ridit分析法处理,可以得出,两组相比有显著差异,而且在治疗期间,未发现任何不良反应或毒副作用,表明用药安全,疗效稳定可靠。
典型病例
病例1:胡某某,女,30岁。尿道口红肿,尿道刺疼,会阴肛门胀疼,小腹坠胀,腰骶疼,大腿两侧不适、乏力、尿频、性功能减退。医生观察:面色晦暗、舌尖红、舌苔薄白、脉细数无力。诊断:支原体感染性毒邪,病久引起的寒热夹杂症,既有肝肾阴虚火旺症,又有脾肾阳虚之虚寒症。采用本发明中药,治疗2个疗程症状基本消失,后又治疗1个疗程症状全部消失,最后巩固1疗程痊愈。至今未见复发。
病例2:王某某,男,30岁。:患无菌性前列腺炎三年余,经多方治疗无满意疗效。现症:小腹、会阴、睾丸、左大腿根部胀痛,尿频、尿急,余无他症。WBC(++),卵磷脂小体(+)。用本发明中药治疗,上午服药下午见效,共服药二十余日,诸症全退,经医院检查完全达到治愈标准。
病例3:姜某某,男,32。:半年前感染支原体、衣原体引起尿道炎没彻底治愈,近期下部出现明显疼痛,经医院检查为急性前列腺炎。尿频尿急,尿道灼痛,小便黄赤,大便硬结,睾丸、会阴胀痛,腹股沟胀痛,后腰胀痛。用本发明胶囊药治疗,服药7天见效,半月后痊愈。
病例4,王某某,女,38岁,症见尿频、尿急、排尿困难,白带增多,宫颈充血、红肿;分泌物涂片革兰染色,高倍显微镜视野下,多形核白细胞数大于5个,淋球菌检查及培养阴性,经病原微生物分离培养可见到支原体,舌质淡红,苔黄腻,脉弦滑数。诊断为非淋菌性尿道炎。服用本发明药物水煎液,每日1剂,1个疗程后,症状明显好转,继续服用3个疗程,痊愈,一年后随访无复发。
以上所述,仅是本发明的最佳实施例而已,并非对本发明作任何形式上的限制,任何熟悉本领域的技术人员,在不脱离本发明技术方案范围情况下,利用上述揭示的方法内容对本发明技术方案做出许多可能的变动和修饰,均属于权利要求书保护的范围。
Claims (9)
1.一种治疗淋菌性尿道炎的中药组合物,其特征在于:由以下各组分组成:苦参0.5-15份、甘草2-10份、枸杞1-10份、通草1-5份、灯心草1-6份、萹蓄1-10份、黄连3-10份、三七1-5份、金银花1-4份、蒲公英1-6份、决明子2-8份、益母草2-10份、虎杖1-5份、莪术1-10份、土荆皮3-10份、芦根0.5-8份、何首乌1-4份、玉竹1-7份、蛤蚧1-8份、肉苁蓉3-18份、黄芪2-10份、金莲花2-8份、香附1-4份、石菖蒲1-5份、白薇1-3份、红大戟2-10份、穿心莲2-8份、马齿苋3-10份、厚朴1-4份、熟地黄2-10份、降香2-8份、皂角刺1-10份、马钱子2-8份、川炼子1-5份、冬葵果1-10份。
2.根据权利要求1所述的一种治疗淋菌性尿道炎的中药组合物,其特征在于:由以下重量份数的各组分组成:
苦参0.5-10份、甘草2-8份、枸杞1-8份、通草1-5份、灯心草1-3份、萹蓄1-10份、黄连3-8份、三七1-5份、金银花1-4份、蒲公英1-6份、决明子2-8份、益母草2-8份、虎杖1-5份、莪术1-8份、土荆皮3-10份、芦根0.5-8份、何首乌1-4份、玉竹1-5份、蛤蚧1-8份、肉苁蓉3-10份、黄芪2-10份、金莲花2-8份、香附1-4份、石菖蒲1-5份、白薇1-3份、红大戟2-10份、穿心莲2-8份、马齿苋3-10份、厚朴1-4份、熟地黄2-8份、降香2-5份、皂角刺1-8份、马钱子2-8份、川炼子1-5份、冬葵果1-8份。
3.根据权利要求1至2所述的一种治疗淋菌性尿道炎的中药组合物,其特征在于:由以下重量份数的各组分组成:苦参0.5份、甘草4份、枸杞3份、通草1份、灯心草1份、萹蓄3份、黄连3份、三七2份、金银花3份、蒲公英3份、决明子2份、益母草4份、虎杖1份、莪术2份、土荆皮3份、芦根2份、何首乌2份、玉竹1份、蛤蚧1份、肉苁蓉3份、黄芪2份、金莲花3份、香附2份、石菖蒲1份、白薇1份、红大戟2份、穿心莲3份、马齿苋3份、厚朴1份、熟地黄2份、降香1份、皂角刺2份、马钱子3份、川炼子1份、冬葵果2份。
4.根据权利要求1至3所述的一种治疗淋菌性尿道炎的中药组合物,其特征在于:由以下重量份数的各组分组成:苦参0.5份、甘草6份、枸杞5份、通草1份、灯心草2份、萹蓄2份、黄连3份、三七2份、金银花4份、蒲公英4份、决明子3份、益母草2份、虎杖1份、莪术1份、土荆皮3份、芦根1份、何首乌2份、玉竹1份、蛤蚧2份、肉苁蓉3份、黄芪2份、金莲花3份、香附2份、石菖蒲1份、白薇1份、红大戟2份、穿心莲3份、马齿苋3份、厚朴1份、熟地黄2份、降香1份、皂角刺2份、马钱子3份、川炼子1份、冬葵果2份。
5.根据权利要求1至4所述的一种治疗淋菌性尿道炎的中药组合物,其特征在于:所述中药制剂的剂型为:所述的药剂为汤剂、口服液、颗粒剂、散剂、胶囊剂、冲剂或片剂。
6.根据权利要求1至5所述的一种治疗淋菌性尿道炎的中药组合物的制备方法,其特征在于:包括以下步骤:
(1)按处方取苦参、甘草、枸杞、通草、灯心草、萹蓄、黄连、三七、金银花、蒲公英、决明子、益母草、虎杖、莪术、土荆皮、芦根、何首乌、玉竹、蛤蚧、肉苁蓉、黄芪、金莲花、香附、石菖蒲、白薇、红大戟、穿心莲、马齿苋、厚朴、熟地黄、降香、皂角刺、马钱子、川炼子、冬葵果放入不锈钢锅内,加常温下的水,加水量没过中药上层面1厘米,浸泡150分钟,加热10分钟,过滤制得一次过滤药液,并留渣,将所得一次过滤药液放在暂存容器内暂存;再向盛有药渣的锅中倒入开水,加开水量没过药渣上层面1厘米,加热10分钟,过滤得二次过滤药液,并去渣,将两次得到的过滤药液混合。
(2)将步骤(1)得到的过滤混合药液减压蒸馏,浓缩得到膏体,干燥粉碎得到粉末。
(3)步骤(3)所得粉末与药物辅料制得相应的制剂。
7.根据权利要求6所述的一种治疗淋菌性尿道炎的中药组合物的制备方法,其特征在于:包括以下步骤:取苦参、甘草、枸杞、通草、灯心草、萹蓄、黄连、三七、金银花、蒲公英、决明子、益母草、虎杖、莪术、土荆皮、芦根、何首乌、玉竹、蛤蚧、肉苁蓉、黄芪、金莲花、香附、石菖蒲、白薇、红大戟、穿心莲、马齿苋、厚朴、熟地黄、降香、皂角刺、马钱子、川炼子、冬葵果药材洗净、烘干粉碎药材加水煎煮两次,第一次加水5-10倍量,煮沸1-5小时;第二次加水4-8倍量,煮沸0.5-3小时,合并煎液,过滤,将滤液于55℃浓缩至比重为1.14-1.47,放出浓缩液,加水稀释,静置24小时,取上清液过300-400目滤网,浓缩,然后按常规制剂工艺分别制成相应的胶囊剂、丸剂、片剂、散剂、口服液或颗粒剂。
8.根据权利要求1至5所述的一种治疗淋菌性尿道炎的中药组合物的制备方法,所述剂型为一种药酒,所述药酒的制备:将根据权利要求1或2或3或4所述的中药与黄酒同放在容器内封浸泡7天后,滤渣后即得药酒,或是将根据权利要求1或2或3或4所述的中药与黄酒同煎成液体,滤渣后即得药酒。
9.根据权利要求1所述的治疗淋菌性尿道炎的中药组合物或所述的中药组合物与药学上可接受的药物载体在制备治疗淋菌性尿道炎的药物制剂中的应用。
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CN102512587A (zh) * | 2011-12-27 | 2012-06-27 | 利安华 | 一种治疗病毒性心肌炎的汤剂 |
CN105749179A (zh) * | 2016-04-28 | 2016-07-13 | 于华 | 治疗代谢综合征的中药组合物 |
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CN105749179A (zh) * | 2016-04-28 | 2016-07-13 | 于华 | 治疗代谢综合征的中药组合物 |
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