CN106267028A - 一种治疗肺炎的中药组合物及其制备方法 - Google Patents

一种治疗肺炎的中药组合物及其制备方法 Download PDF

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CN106267028A
CN106267028A CN201610879447.XA CN201610879447A CN106267028A CN 106267028 A CN106267028 A CN 106267028A CN 201610879447 A CN201610879447 A CN 201610879447A CN 106267028 A CN106267028 A CN 106267028A
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rhizoma
radix
herba
chinese medicine
fructus
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不公告发明人
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Qingdao You Cheng New And High Technology Co Ltd
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Qingdao You Cheng New And High Technology Co Ltd
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Abstract

本发明涉及中医药领域,尤其涉及一种治疗肺炎的中药组合物。由百合、绞股蓝、三七、当归、丹参、金银花、桔梗、半枝莲、松萝、黄柏、鱼腥草、黄连、穿心莲、茯苓、桑白皮、茵陈、泽泻、桂皮、牛蒡子、蒲公英、七叶一枝花、甘草、山豆根、柚子皮、大枣、枸杞、天南星、麦冬、山药、莪术、车前草、川芎、仙茅、半夏等组成。本发明相对于现有技术具有疗效好、成本低、局限性小、无不良反应等优点。与同类药物比较,本发明药物具有配伍严谨,药性平和,疗效显著的特点,便于在临床上大面积推广应用。

Description

一种治疗肺炎的中药组合物及其制备方法
技术领域
本发明属于中药学技术领域,具体涉及一种治疗肺炎的中药组合物及其制备方法。
背景技术
肺炎是指终末气道、肺泡和肺间质的炎症。可由细菌、病毒、真菌、寄生虫等致病微生物,以及放射线、吸入性异物等理化因素引起。临床主要症状为发热、咳嗽、咳痰、痰中带血,可伴胸痛或呼吸困难等。幼儿性肺炎,症状常不明显,可有轻微咳嗽。细菌性肺炎采用抗生素治疗,7~10天多可治愈。病毒性肺炎的病情稍轻,抗生素治疗无效。
目前治疗肺炎的药物有很多,以西药居多,西药治疗为主,但是这些药的副作用较大,而且药效还不尽人意,病毒清除率低,复发率较高,抗病毒药物不能彻底清除病毒复制的模板,给了病毒以重新转录复制的条件,病毒易发生变异,形成耐药性。传统医学尽管理论上引古论今,理出有据,但辩证复杂多变,一证一方,不胜其烦,类型兼夹不一,无法形成统一的诊断标准和固定方剂,因而疗效难以肯定;有些病况往往迁延日久,病邪遍布周身,头绪难理,有些患者随着年老体衰,常常损有余而补不足,肺病更难痊愈。
发明内容
为了克服现有技术中的不足,本发明提供一种治疗肺炎的中药组合物,对慢性心衰具有显著疗效。
为了解决上述技术问题,本发明采用的技术方案如下:一种治疗肺炎的中药组合物,由以下重量份数的各组分组成:
百合1-15份、绞股蓝1-15份、三七1-15份、当归1-15份、丹参1-15份、金银花1-15份、桔梗1-15份、半枝莲1-15份、松萝1-15份、黄柏1-15份、鱼腥草1-15份、黄连1-15份、穿心莲1-15份、茯苓1-15份、桑白皮1-15份、茵陈1-15份、泽泻1-15份、桂皮1-15份、牛蒡子1-15份、蒲公英1-15份、七叶一枝花1-15份、甘草1-15份、山豆根1-15份、柚子皮1-15份、大枣1-15份、枸杞1-15份、天南星1-15份、麦冬1-15份、山药1-15份、莪术1-15份、车前草1-15份、川芎1-15份、仙茅1-15份、半夏1-15份、虎杖1-15份、薄荷1-15份、蝉蜕1-15份、葛根1-15份、柴胡1-15份、龙胆草1-15份、板蓝根1-15份、马齿苋1-15份、独活1-15份、路路通1-15份、百部1-15份、麻黄1-15份、太子参1-15份、厚朴1-15份、鹅不食草1-15份、瓜蒌1-15份、牛膝1-15份、瓦楞子1-15份、高良姜1-15份、香附1-15份、枇杷叶1-15份、败酱草1-15份、白芨1-15份。
进一步的,本发明由以下重量份数的各组分组成:
百合1-10份、绞股蓝1-10份、三七1-10份、当归1-10份、丹参1-10份、金银花1-10份、桔梗1-10份、半枝莲1-10份、松萝1-10份、黄柏1-10份、鱼腥草1-10份、黄连1-10份、穿心莲1-10份、茯苓1-10份、桑白皮1-10份、茵陈1-10份、泽泻1-10份、桂皮1-10份、牛蒡子1-10份、蒲公英1-10份、七叶一枝花1-10份、甘草1-10份、山豆根1-10份、柚子皮1-10份、大枣1-10份、枸杞1-10份、天南星1-10份、麦冬1-10份、山药1-10份、莪术1-10份、车前草1-10份、川芎1-10份、仙茅1-10份、半夏1-10份、虎杖1-10份、薄荷1-10份、蝉蜕1-10份、葛根1-10份、柴胡1-10份、龙胆草1-10份、板蓝根1-10份、马齿苋1-10份、独活1-10份、路路通1-10份、百部1-10份、麻黄1-10份、太子参1-10份、厚朴1-10份、鹅不食草1-10份、瓜蒌1-10份、牛膝1-10份、瓦楞子1-10份、高良姜1-10份、香附1-10份、枇杷叶1-10份、败酱草1-10份、白芨1-10份。
进一步的,本发明由以下重量份数的各组分组成:
百合1份、绞股蓝1份、三七1份、当归1份、丹参1份、金银花1份、桔梗1份、半枝莲1份、松萝1份、黄柏1份、鱼腥草1份、黄连1份、穿心莲1份、茯苓1份、桑白皮1份、茵陈1份、泽泻1份、桂皮1份、牛蒡子1份、蒲公英1份、七叶一枝花1份、甘草1份、山豆根1份、柚子皮1份、大枣1份、枸杞1份、天南星1份、麦冬1份、山药1份、莪术1份、车前草1份、川芎1份、仙茅1份、半夏1份、虎杖1份、薄荷1份、蝉蜕1份、葛根1份、柴胡1份、龙胆草1份、板蓝根1份、马齿苋1份、独活1份、路路通1份、百部1份、麻黄1份、太子参1份、厚朴1份、鹅不食草1份、瓜蒌1份、牛膝1份、瓦楞子1份、高良姜1份、香附1份、枇杷叶1份、败酱草1份、白芨1份。
进一步的,本发明所述中药制剂的剂型为:片剂、糖衣片剂、薄膜衣片剂、肠溶衣片剂、硬胶囊剂、软胶囊剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂或糖浆剂。
为了解决上述技术问题,本发明还提供一种治疗肺炎的中药组合物的制备方法,所述胶囊制备包括以下步骤:
a.将所述原料药放入粉碎机粉碎后过筛,
b.将过筛后的中药放入乙醇中加热回流提取2次;
c.再取上述乙醇提取后的药渣,加水加热回流提取2次;
d.将上述两种提取液合并,减压回收乙醇并喷雾干燥,得药粉;药粉装入胶囊制为胶囊剂。
进一步的,所述步骤a中,将所述原料药放入粉碎机粉碎后过200目细筛,使能通过200目筛的细粉量在达到50%,收集通过200目筛的原料细粉备用。
进一步的,所述步骤b中,将过筛后的中药放入乙醇中加热回流提取2次,每次1~3小时,将2次提取液合并静置;所述步骤c中,将上述乙醇提取过的药渣加10倍量水加热回流提取2次,每次1~3小时,将2次提取液合并静置。。
进一步的,所述步骤d中将上述两种提取液合并,减压浓缩相对密度为70℃时1.08的滤液,回收乙醇,将所得滤液调整比重到1.06,通入喷雾干燥机进行喷雾干燥,过喷雾干燥机喷头的压缩空气压力为5kg/m2,干燥室热气流温度是60℃,得原料药粉;将原料药粉装入胶囊。
当所述中药制剂的剂型为口服液剂,其制备步骤包括:
a、取原料药放入水中浸泡,热提取2次,成浸膏状,为组分1;
b、药渣乙醇提取1次,浓缩过滤为浸膏状,为组分2;
c、将上述两种浸膏浓缩成糊状,浓缩液用CO60灭菌,辐照剂量8k,加入糊精,然后真空冷冻密封即得。
当所述内服药物的剂型为丸剂,其制备步骤的包括:
a.将所述原料药混合,切碎,过80目筛,得细药粉备用;
b.将未过筛的粗粉浸泡乙醇中提取2次;
c.再取上述步骤提取后的药渣,加水加热回流提取2次;
d.将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂胶搓成丸剂。
本发明相对于现有技术具有疗效好、成本低、局限性小、无不良反应等优点。本发明是在传统的中医辩证施治的基础上结合临床实践研制而成的,诸药相合,各药相互配伍,达到治疗肺炎的目的。与同类药物比较,本发明药物具有配伍严谨,药性平和,疗效显著的特点,便于在临床上大面积推广应用。
具体实施方式
出《麻疹活人全书》。为内、儿科常见病之一。又名肺闭喘咳、肺风痰喘。以发热、咳嗽、痰多、喘憋等为特征。古代与现代所说的肺炎尚不一致,但说明这种热性病是麻疹最易出现的合并症。治疗宜疏风宣闭、祛痰平喘、清热解毒、生津止渴。用麻杏石甘汤加银花、连翘、黄芩、板蓝根、水丁香等。重症用三黄石膏汤加减。热极伤阴,心烦气短,可加用生脉散,或沙参麦冬汤加减。如肺炎病灶经治后久久不易吸收,可配合在背部拔火罐。本病发病急、变化快、合并症多。肺炎由可由细菌,病毒,真菌,寄生虫等致病微生物,以及放射线,吸入性异物等理化因素引起。
百合:性味:甘,寒。归经:归心、肺经。功能主治:养阴润肺,清心安神。用于阴虚久咳,痰中带血,虚烦惊悸,失眠多梦,精神恍惚。
绞股蓝:性味:味苦;微甘;性凉。归经:归肺;脾;肾经。功能主治:清热;补虚;解毒。主体虚乏力;虚劳失精;白细胞减少症;高脂血症;病毒性肝炎;慢性胃肠炎;慢性气管炎。
三七:性味:甘、微苦,温。归经:归肝、胃经。功能主治:散瘀止血,消肿定痛。用于咯血,吐血,衄血,便血,崩漏,外伤出血,胸腹剌痛,跌扑肿痛。
当归:性味:甘、辛,温。归经:归肝、心、脾经。功能主治:补血活血,调经止痛,润肠通便。用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡。酒当归活血通经。用于经闭痛经,风湿痹痛,跌扑损伤。
丹参:性味:苦,微寒。归经:归心、肝经。功能主治:祛瘀止痛,活血通经,清心除烦。用于月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠;肝脾肿大,心绞痛。
金银花:性味:甘,寒。归经:归肺、心、胃经。功能主治:清热解毒,凉散风热。用于痈肿疔疮,喉痹,丹毒,热毒血痢,风热感冒,温病发热。
桔梗:性味:苦、辛,平。归经:归肺经。功能主治:宣肺,利咽,祛痰,排脓。用于咳嗽痰多,胸闷不畅,咽痛,音哑,肺痈吐脓,疮疡脓成不溃。
半枝莲:性味:辛、苦,寒。归经:归肺、肝、肾经。功能主治:清热解毒,化瘀利尿。用于疔疮肿毒,咽喉肿痛,毒蛇咬伤,跌扑伤痛,水肿,黄疸。
松萝:性味:甘,平。有小毒。功能主治:清热解毒,止咳化痰。用于肺结核(多用松萝酸的钠盐),慢性支气管炎;外用治创伤感染,术后刀口感染,化脓性中耳炎,疮疖,淋巴结结核,乳腺炎,烧伤,子宫颈糜烂,阴道滴虫。
黄柏:性味:苦,寒。归经:归肾、膀胱经。功能主治:清热燥湿,泻火除蒸,解毒疗疮。用于湿热泻痢,黄疸,带下,热淋,脚气,痿{辟},骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹瘙痒。盐黄柏滋阴降火。用于阴虚火旺,盗汗骨蒸。《本草经疏》:"阴阳两虚之人,病兼脾胃薄弱,饮食少进及食不消,或兼泄泻,或恶冷物及好热食;肾虚天明作泄;上热下寒,小便不禁;少腹冷痛,子宫寒;血虚不孕,阳虚发热,瘀血停滞,产后血虚发热,金疮发热;痈疽溃后发热,伤食发热,阴虚小水不利,痘后脾虚小水不利,血虚不得眠,血虚烦躁,脾阴不足作泄等证,法咸忌之。"
鱼腥草:性味:辛,微寒。归经:归肺经。功能主治:清热解毒,消痈排脓,利尿通淋。用于肺痈吐脓,痰热喘咳,热痢,热淋,痈肿疮毒。
黄连:性味:苦,寒。归经:归心、脾、胃、肝、胆、大肠经。功能主治:清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,血热吐衄,目赤,牙痛,消渴,痈肿疔疮;外治湿疹,湿疮,耳道流脓。酒黄连善清上焦火热。用于目赤,口疮。姜黄连清胃和胃止呕。用于寒热互结,湿热中阻,痞满呕吐。萸黄连舒肝和胃止呕。用于肝胃不和,呕吐吞酸。
穿心莲:性味:苦,寒。归经:归心、肺、大肠、膀胱经。功能主治:清热解毒,凉血,消肿。用于感冒发热,咽喉肿痛,口舌生疮,顿咳劳嗽,泄泻痢疾,热淋涩痛,痈肿疮疡,毒蛇咬伤。
茯苓:性味:甘、淡,平。归经:归心、肺、脾、肾经。功能主治:利水渗湿,健脾宁心。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
桑白皮:性味:甘,寒。归经:归肺经。功能主治:泻肺平喘,利水消肿。用于肺热喘咳,水肿胀满尿少,面目肌肤浮肿。
茵陈:性味:苦、辛,微寒。归经:归脾、胃、肝、胆经。功能主治:清湿热,退黄疸。用于黄疸尿少,湿疮瘙痒;传染性黄疸型肝炎。
泽泻:性味:甘,寒。归经:归肾、膀胱经。功能主治:利小便,清湿热。用于小便不利,水肿胀满,泄泻尿少,痰饮眩晕,热淋涩痛;高血脂。
桂皮:性味:辛,温。①《开宝本草》:味辛,温,无毒。②《四川中药志》:性大热,味辛甘,有小毒。归经:《四川中药志》:入心、肝、脾、肾四经。功能主治:暖脾胃,散风寒,通血脉。治腹冷胸满,呕吐噎膈,风湿痹痛,跌损瘀滞,血痢肠风。益肝肾,通经脉,散风寒,除湿痹,暖腰膝,止呕吐。治筋骨疼痛,寒泄腹痛,霍乱呕吐,噎膈胸满,膀胱寒疝,腰膝现冷,风湿痹痛及跌损瘀滞等症。
牛蒡子:性味:辛、苦,寒。归经:归肺、胃经。功能主治:疏散风热,宣肺透疹,解毒利咽。用于风热感冒,咳嗽痰多,麻疹,风疹,咽喉肿痛,痄腮丹毒,痈肿疮毒。
蒲公英:性味:苦、甘,寒。归经:归肝、胃经。功能主治:清热解毒,消肿散结,利尿通淋。用于疔疮肿毒,乳痈,瘰疠,目赤,咽痛,肺痈,肠痈,湿热黄疸,热淋涩痛。
七叶一枝花:性味:苦,寒。有小毒。功能主治:清热解毒,消肿止痛。流行性乙型脑炎,胃痛,阑尾炎,淋巴结结核,扁桃体炎,腮腺炎,乳腺炎,毒蛇、毒虫咬伤,疮疡肿毒。
甘草:性味:甘,平。归经:归心、肺、脾、胃经。功能主治:补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
山豆根:味苦,气寒,无毒。入肺经。止咽喉肿痛要药,亦治蛇伤虫咬。然只能治肺经之火邪,止咽痛实神。故治实火之邪则可,治虚火之邪则不可也。
柚子皮:柚肉甘酸,性寒无毒,具有理气化、润肺清肠、补血健脾等功效。鲜柚肉含有类似胰岛素成分,有降血糖功效,极有益于糖尿病、心血管病患者,能治食少、口淡、消化不良等症,常食有帮助消化、除痰止渴、理气散结作用。
大枣:性味:甘,温。归经:归脾、胃经。功能主治:果(大枣):补中益气,养血安神。用于脾虚食少,乏力便溏,妇人脏躁。树皮:消炎,止血,止泻。用于气管炎,肠炎,痢疾,崩漏;外用治外伤出血。根:行气,活血,调经。用于月经不调,红崩,白带。
枸杞子:性味:甘,平。归经:归肝、肾经。功能主治:滋补肝肾,益精明目。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,内热消渴,血虚萎黄,目昏不明。
天南星:性味:苦、辛,温;有毒。归经:归肺、肝、脾经。功能主治:燥湿化痰,祛风止痉,散结消肿。用于顽痰咳嗽,风痰眩晕,中风痰壅,口眼歪斜,半身不遂,癫痫,惊风,破伤风。生用外治痈肿,蛇虫咬伤。
麦冬:味甘、微苦,性微寒,归胃、肺、心经,有养阴润肺、益胃生津、清心除烦的功效,用于肺燥干咳、阴虚痨嗽、喉痹咽痛、津伤口渴、内热消渴、心烦失眠、肠燥便秘等症。
山药:性味:甘,平。归经:归脾、肺、肾经。功能主治:补脾养胃,生津益肺,补肾涩精。用于脾虚食少,久泻不止,肺虚喘咳,肾虚遗精,带下,尿频,虚热消渴。麸炒山药补脾健胃。用于脾虚食少,泄泻便溏,白带过多。
莪术:性味:味辛;苦;性温。归经:归肝、脾经。功能主治:行气破血;消积止痛。主血气心痛;饮食积滞;脘腹胀痛;血滞经闭;痛经;症瘕瘤痞块;跌打损伤。
车前草:性味甘、寒。能清热利尿、清肝明目、祛痰止咳、渗湿止泻。适用于湿热内郁之水肿;泌尿系感染时出现的尿频、尿急、尿痛;暑热泄泻、菌痢;肝热所致的目赤肿痛,怕光流泪,视物昏花。
川芎:性味:辛,温。归经:归肝、胆、心包经。功能主治:活血行气,祛风止痛。用于月经不调,经闭痛经,症瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。
仙茅:性味:辛,热;有毒。归经:归肾、肝、脾经。功能主治:补肾阳,强筋骨,祛寒湿。用于阳痿精冷,筋骨痿软,腰膝冷痹,阳虚冷泻。
半夏:性味:辛,温;有毒。归经:归脾、胃、肺经。功能主治:燥湿化痰,降逆止呕,消痞散结。用于痰多咳喘,痰饮眩悸,风痰眩晕,痰厥头痛,呕吐反胃,胸脘痞闷,梅核气;生用外治痈肿痰核。姜半夏多用于降逆止呕。
虎杖:性味:微苦,微寒。归经:归肝、胆、肺经。功能主治:祛风利湿,散瘀定痛,止咳化痰。用于关节痹痛,湿热黄疸,经闭,症瘕,水火烫伤,跌扑损伤,痈肿疮毒,咳嗽痰多。
薄荷:性味:辛,凉。归经:归肺、肝经。功能主治:宣散风热。清头目,透疹。用于风热感冒,风温初起,头痛,目赤,喉痹,口疮,风疹,麻疹,胸胁胀闷。
蝉蜕:性味:甘,寒。归经:归肺、肝经。功能主治:散风除热,利咽,透疹,退翳,解痉。用于风热感冒,咽痛,音哑,麻疹不透,风疹瘙痒,目赤翳障,惊风抽搐,破伤风。
葛根:性味:甘、辛,凉。归经:归脾、胃经。功能主治:解肌退热,生津,透疹,升阳止泻。用于外感发热头痛、项背强痛,口渴,消渴,麻疹不透,热痢,泄泻;高血压颈项强痛。
柴胡:性味:苦,微寒。归经:归肝、胆经。功能主治:和解表里,疏肝,升阳。用于感冒发热,寒热往来,胸胁胀痛,月经不调,子官脱垂,脱肛。
龙胆草:性味:苦,寒。归经:归肝、胆经。功能主治:清热燥湿,泻肝胆火。用于湿热黄疸,阴肿阴痒,带下,强中,湿疹瘙痒,目赤,耳聋,胁痛,口苦,惊风抽搐。
板蓝根:性味:苦,寒。①《本草述》:"苦,寒,无毒。"②《分类草药性》:"凉。"归经:《本草便读》:"入肝、胃血分。"功能主治:清热,解毒,凉血。治流感,流脑,乙脑,肺炎,丹毒,热毒发斑,神昏吐衄,咽肿,痄腮,火眼,疮疹,舌绛紫暗,喉痹,烂喉丹痧,大头瘟疫,痈肿;可防治流行性乙型脑炎、急慢性肝炎、流行性腮腺炎、骨髓炎。
马齿苋:功能主治:清热解毒,散血消肿。治热痢脓血,热淋,血淋,带下,痈肿恶疮,丹毒,痕疬。用于湿热所致的腹泻、痢疾,常配黄连、木香。内服或捣汁外敷,治痈肿。亦用于便血、子宫出血,有止血作用。
独活:性味:辛、苦,微温。归经:归肾、膀胱经。功能主治:祛风除湿,通痹止痛。用于风寒湿痹,腰膝疼痛,少阴伏风头痛。
路路通:性味:苦,平。归经:归肝、肾经。功能主治:祛风活络,利水通经。用于关节痹痛,麻木拘挛,水肿胀满,乳少经闭。
百部:性味:甘苦,微温。①《别录》:"微温。"②陶弘景:"似天门冬而苦强,亦有小毒。"③《药性论》:"味甘,无毒。"④《日华子本草》:"味苦,无毒。"归经:入肺经。①《滇南本草》:"入肺。"②《本草新编》:"入肺经,亦入脾、胃。"功能主治:温润肺气,止咳,杀虫。治风寒咳嗽,百日咳,肺结核,老年咳喘,蛔虫、蛲虫病,皮肤疥癣、湿疹。
麻黄:性味:辛、微苦,温。归经:归肺、膀胱经。功能主治:发汗散寒,宣肺平喘,利水消肿。用于风寒感冒,胸闷喘咳,风水浮肿;支气管哮喘。蜜麻黄润肺止咳。多用于表症已解,气喘咳嗽。
太子参:性味:甘、微苦,平。归经:归脾、肺经。功能主治:益气健脾,生津润肺。用于脾虚体倦,食欲不振,病后虚弱,气阴不足,自汗口渴,肺燥干咳。
厚朴:性味:苦、辛,温。归经:归脾、胃、肺、大肠经。功能主治:燥湿消痰,下气除满。用于湿滞伤中,脘痞吐泻,食积气滞,腹胀便秘,痰饮喘咳。
鹅不食草:性味:辛,温。归经:归肺、肝经。功能主治:通鼻窍,止咳,用于风寒头痛,咳嗽痰多,鼻塞不通,鼻渊流涕。
瓜蒌:性味:甘、微苦、寒。归经:归肺、胃、大肠经。功能主治:清热涤痰,宽胸散结,润燥滑肠。用于肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肺痈,肠痈肿痛,大便秘结。
牛膝:性味:甘、微苦,平。归经:归肝、肾经。功能主治:逐瘀通经,通利关节,利尿通淋。用于经闭症瘕,胞衣不下,关节痹痛,足痿筋挛,尿血血淋,跌扑损伤。
瓦楞子:性味:咸,平。归经:归肺、胃、肝经。功能主治:消痰化瘀,软坚散结,制酸止痛。用于顽痰积结,黏稠难咯,瘿瘤,瘰疬,症瘕痞块,胃痛泛酸。
高良姜:性味:辛,热。归经:归脾、胃经。功能主治:温胃散寒,消食止痛。用于脘腹冷痛,胃寒呕吐,嗳气吞酸。
香附:性味:辛、微苦、微甘,平。归经:归肝、脾、三焦经。功能主治:行气解郁,调经止痛。用于肝郁气滞,胸、胁、脘腹胀痛,消化不良,胸脘痞闷,寒疝腹痛,乳房胀痛,月经不调,经闭痛经。
枇杷叶:性味:苦,微寒。归经:归肺、胃经。功能主治:清肺止咳,降逆止呕。用于肺热咳嗽,气逆喘急,胃热呕逆,烦热口渴。
败酱草:性味:辛、苦,凉。归经:入胃、大肠、肝经。功能主治:清热解毒,消痈排脓,活血行瘀。用于肠痈、肺痈及疮痈肿毒,实热瘀滞所致的胸腹疼痛,产后瘀滞腹痛等症。
白芨:别名:连及草、甘根、白给、箬兰、朱兰、紫兰、紫蕙、百笠。有收敛止血,消肿生肌的功效。用于咳血吐血,外伤出血,疮疡肿毒,皮肤皲裂;肺结核咳血,溃疡病出血。外感咳血,肺痈初起及肺胃有实热者忌服。
下面结合具体实施例对本发明做进一步阐述。
实施例1
将百合1份、绞股蓝1份、三七1份、当归1份、丹参1份、金银花1份、桔梗1份、半枝莲1份、松萝1份、黄柏1份、鱼腥草1份、黄连1份、穿心莲1份、茯苓1份、桑白皮1份、茵陈1份、泽泻1份、桂皮1份、牛蒡子1份、蒲公英1份、七叶一枝花1份、甘草1份、山豆根1份、柚子皮1份、大枣1份、枸杞1份、天南星1份、麦冬1份、山药1份、莪术1份、车前草1份、川芎1份、仙茅1份、半夏1份、虎杖1份、薄荷1份、蝉蜕1份、葛根1份、柴胡1份、龙胆草1份、板蓝根1份、马齿苋1份、独活1份、路路通1份、百部1份、麻黄1份、太子参1份、厚朴1份、鹅不食草1份、瓜蒌1份、牛膝1份、瓦楞子1份、高良姜1份、香附1份、枇杷叶1份、败酱草1份、白芨1份原料药放入粉碎机粉碎后过200目细筛,使能通过200目筛的细粉量在达到50%,收集通过200目筛的原料细粉备用。将过筛后的中药放入乙醇中加热回流提取2次,每次1~3小时,将2次提取液合并静置。将上述乙醇提取过的药渣加10倍量水加热回流提取2次,每次1~3小时,将2次提取液合并静置。将上述两种提取液合并,减压浓缩相对密度为70℃时1.08的滤液,回收乙醇,将所得滤液调整比重到1.06,通入喷雾干燥机进行喷雾干燥,过喷雾干燥机喷头的压缩空气压力为5kg/m2,干燥室热气流温度是60℃,得原料药粉;将原料药粉装入胶囊
实施例2
将百合1份、绞股蓝1份、三七1份、当归1份、丹参1份、金银花1份、桔梗1份、半枝莲1份、松萝1份、黄柏1份、鱼腥草1份、黄连1份、穿心莲1份、茯苓1份、桑白皮1份、茵陈1份、泽泻1份、桂皮1份、牛蒡子1份、蒲公英1份、七叶一枝花1份、甘草1份、山豆根1份、柚子皮1份、大枣1份、枸杞1份、天南星1份、麦冬1份、山药1份、莪术1份、车前草1份、川芎1份、仙茅1份、半夏1份、虎杖1份、薄荷1份、蝉蜕1份、葛根1份、柴胡1份、龙胆草1份、板蓝根1份、马齿苋1份、独活1份、路路通1份、百部1份、麻黄1份、太子参1份、厚朴1份、鹅不食草1份、瓜蒌1份、牛膝1份、瓦楞子1份、高良姜1份、香附1份、枇杷叶1份、败酱草1份、白芨1份原料药放入粉碎机粉碎后过100目细筛,使能通过100目筛的细粉量在达到50%,收集通过100目筛的原料细粉备用;将过筛后的中药放入乙醇中加热回流提取2次,每次1~3小时,将2次提取液合并静置;将上述乙醇提取过的药渣加10倍量水加热回流提取2次,每次1~3小时,将2次提取液合并静置。将上述两种提取液合并,减压浓缩干燥成干膏,混合粉碎,加10%氯化钠,冷藏,分取上层清液,加入4倍量β-环糊精,适量水,加入环糊精包合物、淀粉、混合均匀,压片,再用薄膜包衣液,进行包衣,即得片剂。
实施例3
将百合1份、绞股蓝1份、三七1份、当归1份、丹参1份、金银花1份、桔梗1份、半枝莲1份、松萝1份、黄柏1份、鱼腥草1份、黄连1份、穿心莲1份、茯苓1份、桑白皮1份、茵陈1份、泽泻1份、桂皮1份、牛蒡子1份、蒲公英1份、七叶一枝花1份、甘草1份、山豆根1份、柚子皮1份、大枣1份、枸杞1份、天南星1份、麦冬1份、山药1份、莪术1份、车前草1份、川芎1份、仙茅1份、半夏1份、虎杖1份、薄荷1份、蝉蜕1份、葛根1份、柴胡1份、龙胆草1份、板蓝根1份、马齿苋1份、独活1份、路路通1份、百部1份、麻黄1份、太子参1份、厚朴1份、鹅不食草1份、瓜蒌1份、牛膝1份、瓦楞子1份、高良姜1份、香附1份、枇杷叶1份、败酱草1份、白芨1份原料药放入粉碎机粉碎后过100目细筛,使能通过100目筛的细粉量在达到50%,收集通过100目筛的原料细粉;将过筛后的细粉放入水中浸泡,热提取2次,成浸膏状,为组分1;药渣加10倍量水加热回流提取2次,每次1~2小时,浓缩过滤为浸膏状,为组分2;将上述两种浸膏浓缩成糊状,浓缩液用CO60灭菌,辐照剂量8k,加入糊精,然后真空冷冻密封即得。
毒性试验:
实验动物
小白鼠由青岛市实验动物和动物实验中心提供。
小白鼠灌胃给药急性毒性实验
应用小鼠进行急性毒性实验表明:小鼠口服灌胃本发明的中药制剂胶囊剂,在387.1g生药/kg剂量下,给药后小鼠出现轻微活动减少,1小时左右恢复正常,给药后连续观察7天,无一动物死亡,其全身状况、饮食、摄水、小便和体重增长均正常,实验结果表明:小鼠口服灌胃本发明的中药制剂胶囊剂的最大给药量为388.8g生药/kg/d(LD50>388.8g生药/kg)。本发明的中药制剂每日临床用药总量为0.1g生药/kg/d;按体重计,小鼠灌胃本发明的中药制剂的耐受量为临床病人的3888倍。提示该药急性毒性低,临床用药安全。
大鼠灌胃给药长期毒性实验
毒性试验:
选用SD大鼠,给予不同浓度(16.0、5.0、1.0g生药/kg)的本发明的中药制剂片剂,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动物(雌雄各半),其余1/2动物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90天和停药2周进行血液学(RBC、HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、ALP、Glu、BUN、Crea、TP、T.BIL、ALB、CHOL)、尿液生化、脏器系数、病理组织学等指标检查。试验结果表明:本发明的中药制剂在高、中、低剂量组动物一般状态良好,外观体征、行为活动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的160、50、10倍,根据试验结果本发明的中药制剂在高、中、低三个剂量(16.0、5.0、1.0g生药/kg)连续90天给药对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应,提示本发明的中药制剂临床应用的剂量安全性较高。
临床资料。
(1)实验材料:
本发明人于2010年至今,对490例肺炎患者进行临床观察治疗,其中,男305例,女185例。
(2)治疗方法
温水内服,一日三次,每次一包,饭后服用。根据患者病情轻重计算治疗时间,轻度患者服用1个月左右,重病患者连服3个月即可痊愈。
(3)疗效判定标准
“治愈”:临床症状体征消失,恢复正常。
“显效”:临床症状体征基本或大部分消失。
“有效”:临床症状明显好转。
“无效”:临床症状体征无改善。
(4)治疗效果:
临床治愈352例,占71.84%;显效118例,占24.08%;无效20例,总有效率95.92%。
本发明配制简单,吸收效果好,疗效显著,无副作用,安全性高,有利于患者及时减轻病状。对于490例患者在治疗过程中进行跟踪观察,未发现明显的不良反应。
以上所述,仅是本发明的最佳实施例而已,并非对本发明作任何形式上的限制,任何熟悉本领域的技术人员,在不脱离本发明技术方案范围情况下,利用上述揭示的方法内容对本发明技术方案做出许多可能的变动和修饰,均属于权利要求书保护的范围。

Claims (10)

1.一种治疗肺炎的中药组合物,其特征在于:由以下各组分组成:百合1-15份、绞股蓝1-15份、三七1-15份、当归1-15份、丹参1-15份、金银花1-15份、桔梗1-15份、半枝莲1-15份、松萝1-15份、黄柏1-15份、鱼腥草1-15份、黄连1-15份、穿心莲1-15份、茯苓1-15份、桑白皮1-15份、茵陈1-15份、泽泻1-15份、桂皮1-15份、牛蒡子1-15份、蒲公英1-15份、七叶一枝花1-15份、甘草1-15份、山豆根1-15份、柚子皮1-15份、大枣1-15份、枸杞1-15份、天南星1-15份、麦冬1-15份、山药1-15份、莪术1-15份、车前草1-15份、川芎1-15份、仙茅1-15份、半夏1-15份、虎杖1-15份、薄荷1-15份、蝉蜕1-15份、葛根1-15份、柴胡1-15份、龙胆草1-15份、板蓝根1-15份、马齿苋1-15份、独活1-15份、路路通1-15份、百部1-15份、麻黄1-15份、太子参1-15份、厚朴1-15份、鹅不食草1-15份、瓜蒌1-15份、牛膝1-15份、瓦楞子1-15份、高良姜1-15份、香附1-15份、枇杷叶1-15份、败酱草1-15份、白芨1-15份。
2.根据权利要求1所述的一种治疗肺炎的中药组合物,其特征在于:由以下重量份数的各组分组成:
百合1-10份、绞股蓝1-10份、三七1-10份、当归1-10份、丹参1-10份、金银花1-10份、桔梗1-10份、半枝莲1-10份、松萝1-10份、黄柏1-10份、鱼腥草1-10份、黄连1-10份、穿心莲1-10份、茯苓1-10份、桑白皮1-10份、茵陈1-10份、泽泻1-10份、桂皮1-10份、牛蒡子1-10份、蒲公英1-10份、七叶一枝花1-10份、甘草1-10份、山豆根1-10份、柚子皮1-10份、大枣1-10份、枸杞1-10份、天南星1-10份、麦冬1-10份、山药1-10份、莪术1-10份、车前草1-10份、川芎1-10份、仙茅1-10份、半夏1-10份、虎杖1-10份、薄荷1-10份、蝉蜕1-10份、葛根1-10份、柴胡1-10份、龙胆草1-10份、板蓝根1-10份、马齿苋1-10份、独活1-10份、路路通1-10份、百部1-10份、麻黄1-10份、太子参1-10份、厚朴1-10份、鹅不食草1-10份、瓜蒌1-10份、牛膝1-10份、瓦楞子1-10份、高良姜1-10份、香附1-10份、枇杷叶1-10份、败酱草1-10份、白芨1-10份。
3.根据权利要求1至2所述的一种治疗肺炎的中药组合物,其特征在于:由以下重量份数的各组分组成:百合1份、绞股蓝1份、三七1份、当归1份、丹参1份、金银花1份、桔梗1份、半枝莲1份、松萝1份、黄柏1份、鱼腥草1份、黄连1份、穿心莲1份、茯苓1份、桑白皮1份、茵陈1份、泽泻1份、桂皮1份、牛蒡子1份、蒲公英1份、七叶一枝花1份、甘草1份、山豆根1份、柚子皮1份、大枣1份、枸杞1份、天南星1份、麦冬1份、山药1份、莪术1份、车前草1份、川芎1份、仙茅1份、半夏1份、虎杖1份、薄荷1份、蝉蜕1份、葛根1份、柴胡1份、龙胆草1份、板蓝根1份、马齿苋1份、独活1份、路路通1份、百部1份、麻黄1份、太子参1份、厚朴1份、鹅不食草1份、瓜蒌1份、牛膝1份、瓦楞子1份、高良姜1份、香附1份、枇杷叶1份、败酱草1份、白芨1份。
4.根据权利要求1至3所述的一种治疗肺炎的中药组合物,其特征在于:所述中药制剂的剂型为:片剂、糖衣片剂、薄膜衣片剂、肠溶衣片剂、硬胶囊剂、软胶囊剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂或糖浆剂。。
5.根据权利要求1至4所述的一种治疗肺炎的中药组合物的制备方法,其特征在于:所述胶囊制备的包括以下步骤:
a.将所述原料药放入粉碎机粉碎后过筛;
b.将过筛后的中药放入乙醇中加热回流提取2次;
c.再取上述乙醇提取后的药渣,加水加热回流提取2次;
d.将上述两种提取液合并,减压回收乙醇并喷雾干燥,得药粉;药粉装入胶囊制为胶囊剂。
6.根据权利要求5所述的一种治疗肺炎的中药组合物的制备方法,其特征在于:所述步骤的a中,将所述原料药放入粉碎机粉碎后过200目细筛,使能通过200目筛的细粉量在达到50%,收集通过200目筛的原料细粉备用。
7.根据权利要求5所述的一种治疗肺炎的中药组合物的制备方法,其特征在于:所述步骤b中,将过筛后的中药放入乙醇中加热回流提取2次,每次1~3小时,将2次提取液合并静置;所述步骤c中,将上述乙醇提取过的药渣加10倍量水加热回流提取2次,每次1~3小时,将2次提取液合并静置。。
8.根据权利要求6所述的一种治疗肺炎的中药组合物的制备方法,其特征在于:所述步骤d中将上述两种提取液合并,减压浓缩相对密度为70℃时1.08的滤液,回收乙醇,将所得滤液调整比重到1.06,通入喷雾干燥机进行喷雾干燥,过喷雾干燥机喷头的压缩空气压力为5kg/m2,干燥室热气流温度是60℃,得原料药粉;将原料药粉装入胶囊。
9.一种如权利要求1至4所述的治疗慢性心衰的中药组合物的制备方法,其特征在于,所述中药制剂的剂型为口服液剂,其制备步骤包括:
a、取原料药放入水中浸泡,热提取2次,成浸膏状,为组分1;
b、药渣乙醇提取1次,浓缩过滤为浸膏状,为组分2;
c、将上述两种浸膏浓缩成糊状,浓缩液用CO60灭菌,辐照剂量8k,加入糊精,然后真空冷冻密封即得。
10.一种如权利要求1至4所述的治疗慢性心衰的中药组合物的制备方法,其特征在于:所述内服药物的剂型为丸剂,其制备步骤的包括:
a.将所述原料药混合,切碎,过80目筛,得细药粉备用;
b.将未过筛的粗粉浸泡乙醇中提取2次;
c.再取上述步骤提取后的药渣,加水加热回流提取2次;
d.将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂胶搓成丸剂。
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CN111529638A (zh) * 2020-05-27 2020-08-14 贾庭山 一种清肺消炎的中药组合物及其制备方法和应用
CN115414466A (zh) * 2022-05-19 2022-12-02 北京荣寿堂生物科技有限公司 一种提高免疫力的胶囊及其制备方法

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CN105435131A (zh) * 2016-01-14 2016-03-30 青岛友诚高新技术有限公司 一种治疗慢性心衰的中药组合物及其制备方法

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CN105435131A (zh) * 2016-01-14 2016-03-30 青岛友诚高新技术有限公司 一种治疗慢性心衰的中药组合物及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111529638A (zh) * 2020-05-27 2020-08-14 贾庭山 一种清肺消炎的中药组合物及其制备方法和应用
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