CN106138697A - 预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物 - Google Patents
预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物 Download PDFInfo
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Abstract
预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物，由以下成分组成：仙鹤草30‑50g、熟地黄30‑50g、麦冬20‑40g、枸杞子20‑40g、当归10‑20g、炒白芍药10‑30g、白茯苓10‑20g、白术10‑30g、炙甘草5‑10g。其制备方法包括称取上述药物，用蒸馏水浸泡后煎煮，滤出煎液；然后再次加水煎煮滤出煎液，把两次煎煮液混合浓缩得到热浓缩液即得。本发明取材方便、容易制作，采用中药组方联合使用，协同作用，具有使用方便，成本低廉，经济实惠，无毒无害，使用效果明确的优点，使放化疗得以顺利有效地进行，改善病人生活质量，延长生存期。
Description
技术领域
本发明涉及到一种预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物及制备方法，以预防肿瘤病人放化疗后并发症及减轻副作用，属于中药领域。
背景技术
肺癌病人放化疗过程中，化疗放疗在杀死肿瘤细胞的同时，也对免疫系统及各重要器官造成严重损伤，病人会出现恶心、纳差、呕吐、乏力、气短、胸闷、心慌等不适。辅助治疗的西药又往往针对单一毒副反应，比如呕吐药用止吐药，增加白细胞要打增白针，单一药品无法缓解所有副作用。而这一方面，中药则能从根本上起到扶正固本，全面减轻放化疗副作用，而临床常用的单药或组方中成药，作用单一，收效甚微，部分病人因此中断治疗，使治疗效果大打折扣，部分药物还会因药物提纯度不够在静脉注射时引起过敏反应，甚至危及生命。
发明内容
本发明的目的是要提供一种预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物及制备方法，作为一种疗效确实，花费较低，使用方便，无毒副作用的中药组合，能够针对肺癌放化疗病人气血亏虚，通过益气补血，达到改善食欲、增加病人抵抗力，从而减轻放化疗副作用，使放化疗得以顺利有效地进行，改善病人生活质量，延长生存期，以弥补现有技术的不足。
一种预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物，其特征在于该组合物由以下成分组成：仙鹤草30-50g、熟地黄30-50g、麦冬20-40g、枸杞子20-40g、当归10-20g、炒白芍药10-30g、白茯苓10-20g、白术10-30g、炙甘草5-10g。
该组方由以下成分组成：仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g。
对于合并有咯血的病人，该组合物由以下成分组成：仙鹤草50g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g。仙鹤草有止血作用，对于合并有咯血的病人，可适当增加其在组方中的份额数。
对于合并有疼痛的病人，该组合物由以下成分组成：仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草10g。炙甘草有止痛作用，对于合并有疼痛的病人，可适当增加其在组方中的份额数。
上述的中药组合物在预防肿瘤病人放化疗中并发症及减轻副作用发生中的应用。
一种预防肿瘤病人放化疗中并发症及减轻副作用的药物的制备方法，其特征在于包括以下步骤：
首先，称取仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g，上述药物用蒸馏水750ml浸泡约1小时后煎煮30分钟，滤出煎液；然后再次加水600克，煎煮20分钟滤出煎液，把两次煎煮液混合浓缩直至得到200ml的热浓缩液；即得到一种预防肿瘤病人放化疗后并发症及减轻副作用的药物。该热浓缩液即作为预防肿瘤病人放化疗后并发症及减轻副作用的药物。
本发明取材方便、容易制作，采用中药组方联合使用，协同作用，具有使用方便，成本低廉，经济实惠，无毒无害，使用效果明确的优点，主要用于预防肿瘤病人放化疗后并发症及减轻副作用，以上诸药配伍共凑，起到益气、养血、润肺、解毒等功效。达到改善食欲、增加病人抵抗力，从而减轻放化疗副作用的作用，使放化疗得以顺利有效地进行，改善病人生活质量，延长生存期。
具体实施方式
一种预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物，其特征在于该组合物由以下成分组成：仙鹤草30-50g、熟地黄30-50g、麦冬20-40g、枸杞子20-40g、当归10-20g、炒白芍药10-30g、白茯苓10-20g、白术10-30g、炙甘草5-10g。
该组合物由以下成分组成：仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g。
对于合并有咯血的病人，该组合物由以下成分组成：仙鹤草50g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g。仙鹤草有止血作用，对于合并有咯血的病人，可适当增加其在组方中的份额数。
对于合并有疼痛的病人，该组合物由以下成分组成：仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草10g。炙甘草有止痛作用，对于合并有疼痛的病人，可适当增加其在组方中的份额数。
上述的中药组合物在预防肿瘤病人放化疗中并发症及减轻副作用发生中的应用。
一种预防肿瘤病人放化疗后并发症及减轻副作用的药物的制备方法，其特征在于包括以下步骤：
首先，称取仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g，上述药物用蒸馏水750ml浸泡约1小时后煎煮30分钟，滤出煎液；然后再次加水600克，煎煮20分钟滤出煎液，把两次煎煮液混合浓缩直至得到200ml的热浓缩液；即得到一种预防肿瘤病人放化疗后并发症及减轻副作用的药物。
以下结合临床数据及典型病例来进一步说明其有益效果。
一、临床观察
1、临床资料
收集2014.01-2015.03间青岛市市立医院肺癌病例共60例，均为肺癌局部晚期病人，所有病人均经组织病理学确诊，临床分期采用AJCC第7版，所有患者III-IV期，无手术机会或不愿意手术，采用同步放化疗，放疗剂量均为60Gy/30F，化疗均采用标准EP方案(顺铂50mg/m2第1、8、29、36天，VP-16 50mg/m2第1～5天，29～33天),随机分为2组，每组30人，实验组在西医对症治疗的基础上，同时服用本药物治疗，对照组给予对症支持治疗，观察2组在减轻放化疗副作用方面及病人PS评分改善情况。
两组病人一般情况比较
1.1观察目标：
共5项，包括病人恶心、呕吐发生情况；胸闷气短缓解情况；骨髓抑制情况；放化疗按时完成情况；病人生存质量评分采用PS评分标准；实体瘤疗效评价标准采用RECIST1.1标准。
1.1.1抗肿瘤药物不良反应的分度标准(WHO标准)
1.1.2肿瘤病人PS评分或ECOG评分基本内容如下：
0分----能正常活动。
1分----有症状，但几乎可完全正常活动。
2分----有时卧床，但白天卧床时间不超过50％。
3分----需要卧床，白天卧床时间超过50％。
4分----卧床不起。
5分----死亡。
治疗后评分降低记为改善。
1.1.3 RECIST1.1标准
目标病灶的评价
CR：所有目标病灶消失。
PR：基线病灶长径总和缩小≥30％。
PD：基线病灶长径总和增加≥20％或出现新病灶。
SD：基线病灶长径总和有缩小但未达PR或有增加但未达PD。
非目标病灶的评价
CR：所有非目标病灶消失和肿瘤标志物水平正常。
SD：一个或多个非目标病灶和/或肿瘤标志物高于正常持续存在。
PD：出现一个或多个新病灶或/和存在非目标病灶进展。
2.结果：
实验组恶心、呕吐发生率；胸闷气短缓解率；放化疗按时完成率；PS评分明显改善(P<0.05)；骨髓抑制率明显降低(P<0.05)
典型病例
病例1张某，男，59岁，因喘憋、咳嗽、咯血就诊，有吸烟史30余年，入院查体左下肺呼吸音低，行双肺CT检查发现左侧胸腔积液，左下肺部分肺不张，左肺肿块与肺不张融为一体，分界不清，行左胸膜活检提示肺腺癌，行同步放化疗加集灵固本汤实施例1药方制备及使用，过程顺利，患者放疗5次后咯血明显缓解，喘憋缓解，9次咯血完全缓解，整个治疗过程顺利，患者无明显恶心、纳差等不适，进食好，体力明显改善，期间亦未出现明显骨髓抑制，放疗结束后1月疗效评价PR。
病例2辛某某，男，62岁，因喘憋、纳差、乏力、低热入院，有吸烟史40年，入院查体左肺呼吸音低，做双肺CT发现左肺门占位，做纤维支气管镜取活检病例示低分化鳞癌，临床分期IIIB期，无手术条件，行同步放化疗，同步加集灵固本汤实施例2药方制备及使用，放化疗期间无明显骨髓抑制，喘憋、纳差、乏力放疗7次后明显改善，发热逐渐缓解，放化疗结束后病灶几乎看不到，放化疗结束后1月疗效评价CR。
病例3刘某某，男，42岁，咳嗽、咳痰伴呼吸困难就诊，无吸烟史，入院查体右肺呼吸音低，做双肺CT示右肺门占位，纵膈淋巴结肿大，做纤支镜取活检病理示小细胞未分化癌，行同步放化疗加集灵固本汤实施例3药方制备及使用，过程顺利，患者无明显恶心、纳差，无明显骨髓抑制，一般情况在治疗期间明显好转，治疗后疗效评价临床CR。
病例4沈某某，男，65岁，咳嗽、喘憋伴发热、乏力1月就诊，有吸烟史40余年，入院查体左肺呼吸音低，双肺CT示右肺门占位，纵膈淋巴结肿大，做纤支镜取活检病理示低分化鳞癌，临床分期IIIA期，请胸外科会诊，考虑可以行手术治疗，病人本人及家属拒绝手术，遂行同步放化疗，期间加集灵固本汤实施例1药方制备和使用，过程顺利，放疗1周后体温基本正常，乏力改善，整个治疗过程患者无明显不适，一般状况逐渐好转，每周复查血常规无明显骨髓抑制，治疗后疗效评价临床CR。
病例5苏某某，男，46岁，因乏力、纳差、喘憋就诊，无吸烟史，入院查体左肺呼吸音略低，双肺CT示左肺近肺门占位，大小1.5*1cm，纵膈淋巴结多发肿大，大者直径达2cm，做纤支镜取活检病理示小细胞未分化癌，行同步放化疗加集灵固本汤实施例3药方制备和使用，治疗过程患者食欲渐改善，乏力好转，喘憋症状缓解，无明显骨髓抑制，按时完成治疗，治疗后疗效评价临床CR。
以上案例表明本发明具有简便易行的操作和切实可靠的疗效。
Claims (6)
1.一种预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物，其特征在于该组合物由以下成分组成：仙鹤草30-50g、熟地黄30-50g、麦冬20-40g、枸杞子20-40g、当归10-20g、炒白芍药10-30g、白茯苓10-20g、白术10-30g、炙甘草5-10g。
2.如权利要求1所述的预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物，其特征在于该组合物由以下成分组成：仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g。
3.如权利要求1所述的预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物，其特征在于该组合物由以下成分组成：仙鹤草50g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g。
4.如权利要求1所述的预防肿瘤病人放化疗中并发症及减轻副作用的中药组合物，其特征在于该组合物由以下成分组成：仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草10g。
5.权利要求1、2、3或4所述的中药组方在预防肿瘤病人放化疗中并发症及减轻副作用发生中的应用。
6.一种预防肿瘤病人放化疗中并发症及减轻副作用的药物的制备方法，其特征在于包括以下步骤：
首先，称取仙鹤草30g、熟地黄30g、麦冬30g、枸杞子30g、当归10g、炒白芍药10g、白茯苓10g、白术10g、炙甘草5g，上述药物用蒸馏水750ml浸泡约1小时后煎煮30分钟，滤出煎液；然后再次加水600克，煎煮20分钟滤出煎液，把两次煎煮液混合浓缩直至得到200ml的热浓缩液；即得到一种预防肿瘤病人放化疗后并发症及减轻副作用的药物。
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