CN106138661A

CN106138661A - The treatment Chinese medicine composition of hepatopathy, preparation method and Chinese medicine preparation thereof

Info

Publication number: CN106138661A
Application number: CN201610861171.2A
Authority: CN
Inventors: 王雪纯
Original assignee: Zhengzhou Sibian Technology Co Ltd
Current assignee: Zhengzhou Sibian Technology Co Ltd
Priority date: 2016-09-29
Filing date: 2016-09-29
Publication date: 2016-11-23

Abstract

The invention provides a kind of Chinese medicine composition treating hepatopathy and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.A kind of Chinese medicine composition treating hepatopathy, is made up of Radix Puerariae, the Rhizoma Anemarrhenae, Fructus Chaenomelis, Herba Schizonepetae, Radix Saposhnikoviae, Herba Ranunculi Japonici, Cortex Phellodendri, Rhizoma Coptidis, Sanguis Draxonis, Radix Notoginseng, Aerugo, Flos Carthami, Ovum Anas domestica, Herba Artemisiae Annuae, Cortex Dictamni, Oleum menthae.Chinese medicine composition coordinated of the present invention, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, strengthening vital QI to eliminate pathogenic factors, dampness removing reduces phlegm, coordinate Medicinal Vesiculation Therapy, degree of having held up of dispelling, bring out the best in each other, give full play to function of human body, change the stagnant state of the internal stasis of blood, get rid of internal hundred poison, improve body immunity, strengthen the human body resistivity to disease.

Description

The treatment Chinese medicine composition of hepatopathy, preparation method and Chinese medicine preparation thereof

Technical field

The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of treat the Chinese medicine composition of hepatopathy, preparation method And Chinese medicine preparation.

Background technology

Hepatopathy is a kind of common disease, as the term suggests being, because of what many reasons caused, the pathological changes at liver, common liver occur Disease includes alcoholic liver disease, chronic hepatitis, hepatic fibrosis, liver cirrhosis, hepatocarcinoma etc..Along with the development of Chinese national economy, people Life style, dietary habit, dietary structure all there occurs change, hepatopathy sickness rate substantially rises in recent years, and youth occurs Change trend.

Alcoholic liver disease, is the hepar damnification disease caused by long-term heavy drinking (being addicted to drink).Ethanol and metabolism thereof Product acetaldehyde etc. damage hepatocyte directly or by immunologic mechanism, and hepatic cell fattydegeneration, alcoholic hepatitis, liver fiber occur Change, liver cirrhosis.The traditional Chinese medical science is thought at present, and the main pathogenesis of alcoholic liver disease is that endogenous dampness is trouble, accumulates or damp-stagnancy heat-transformation, enter in cold-damp One step to insufficiency of the spleen stagnation of liver-QI, the liver failing to maintain the normal flow of QI, qi depression to blood stasis, ultimately result in that the functions such as liver,spleen,kidney are not normal and exhaustion.

Hepatic fibrosis, refers to be caused connective tissue paraplasm in liver, diffusivity extracellular in liver by various paathogenic factors The pathological process of excessive matrix precipitation.Chronic hepatopathy that a variety of causes causes, hepatic injury, all may cause hepatic necrosis, send out Raw justice disease secondary fibrosis, cause lobules of liver structure to build ingeniously further, and pseudolobuli and tuberosity are formed, and pass through different approaches Develop into liver to change ingeniously, ultimately result in the consequence that mouthful venous hypertension and liver failure etc. are serious.Research shows, the liver that chronic hepatopathy causes Gentry's dimensionization disease time compared with long, the state of an illness is intricate, treatment difficulty big.The traditional Chinese medical science think ＂ liver traitor dimension ＂ belong to ＂ blood, internal organs pain, Trace amasss the category of ＂.The main cause of its morbidity is that damp and hot heresy visitor is among venation.Wet for gorgeous stagnant heresy.Hepatic fibrosis is adjoint Chronic hepatopathy, affects prognosis of disease and prognosis, and therefore antifibrosis therapy is modern medicine important content.During anti-hepatic fibrosis is The advantage of medicine, it is adaptable to various Progressive symmetric erythrokeratodermia chronic hepatopathys, such as chronic viral hepatitis, Cirrhosis In Schistosomiasis, AID etc..I State's Liver Fibrosis with Traditional Chinese Medicine medicament research and development is in first place in the world, shows unique characteristics.Anti-hepatic fibrosis conventional Chinese medicine prescription is many Based on softening the hard mass in ancient times, invigorate blood circulation, eliminating stagnation method for the treatment of, lump in the abdomen disease under prolonged illness rib in ancient books, just close modern to various chronic hepatic injuries, The pathological study of liver cirrhosis.

The patent of Application No. 201010258167.X disclose one treat Various Types of Hepatitis and alcoholic liver or its The Chinese medicine composition of the cirrhotic ascites that its reason causes, described Chinese medicine composition includes Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae (parched), Endothelium Corneum Gigeriae Galli (parched), Fu Siberian cocklebur, Polyporus, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Fructus Amomi, Herba Taraxaci, Carapax Trionycis (processed with vinegar), each 5-8 weight portion；Herba Lycopi, Radix Curcumae, Fructus Ligustri Lucidi, Herba Ecliptae, celestial being Grass, each 3-6 weight portion；Radix Rehmanniae Preparata, Rhizoma dioscoreae (parched), Fructus Corni, Cortex Moutan, the Radix Astragali, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei (steaming), Pericarpium Citri Reticulatae Viride, Huang Essence, Radix Puerariae, Pericarpium Arecae, Radix Paeoniae Alba (parched), Radix Glycyrrhizae Preparata, Radix Schisandrae Bicoloris, each 1-3 weight portion；Flos Carthami, Radix Salviae Miltiorrhizae, Cortex Cinnamomi, Rhizoma Imperatae, respectively 0.5-2 weight portion；The Chinese medicine composition of this invention is hard for the liver of Various Types of Hepatitis and alcoholic liver or the initiation of other reason Change ascites and there is good curative effect.The patent of application number 201610000218.6 discloses a kind of purifying the blood in toxin expelling treatment hepatopathy Herbal-composition, Flos Lonicerae 1-2 part；Herba Patriniae 1-2 part；Clear fish gallbladder 0.6-1.2 part；Radix Gentianae 0.6-1.2 part；Palm fibre flower 0.8-1 Part；Bombyx mandarina Moore Radix Sophorae Tonkinensis 0.2-0.5 part, also can optionally add Radix Puerariae, trailing plants cottonrose hibiscus, cottonrose hibiscus wood, Herba Plantaginis, Spica Prunellae, Folium Mori and white Several in Cortex Dictamni.The all medicines of this invention cooperate, and jointly play drug effect, are formed to purify the blood on the whole and regulate the flow of vital energy, strengthen or extensive Effect of the organ self-regenerations such as multiple damaged liver.

" internal diameter Ling Shu Miraculous Pivot or Divine Axis " all kinds of diseases and ailments of the viewpoint of disease of the traditional Chinese medical science acting on so far begin a raw piece: " interaction between two asthenia conditions is its shape of visitor ", Liver of TCM The pathogenetic inside and outside factor of disease is paid close attention in sick treatment.When there is no specially good effect antiviral therapy, the traditional Chinese medical science is main blames in interior, and this just determines The clinic of Chinese traditional treatment hepatopathy and the intension of scientific research and characteristic.At present, the Chinese and Western therapy for hepatopathy is the clearest and the most definite, but the course for the treatment of Longer brought medicine toxicity and patient compliance difference are all problem demanding prompt solutions.Medicinal vesiculation uses dripping of irritant drugs It is applied to skin surface, causes contrafluxion to be foamed, excite meridian qi and blood to run, play the effect adjusting immunity of organism.Liu Wen Lucky etc. (Liu Wenji, Li Shengjie etc. the experimentation [J] of medicinal vesiculation preventing and treating rat liver fibrosis. Shanghai journal of acupuncture and moxibustion, 2015 (5): 460-463) the effect of research powder of cantharide medicinal vesiculation preventing and treating rat liver fibrosis (HF), finds that medicinal vesiculation has and certain prevents and treats rats'liver Fibrotic effect, and speculate: the effect above may belong to same nerve segment with bl, Qimen with liver, the machinery that medicinal vesiculation produces It is relevant that stimulation can play its meridians regulation effect;Also or with medicinal vesiculation produce chemical stimulation excitating organism immunity relevant.It addition, Medicinal ingredient in Mylabris also plays the effect that can not be ignored, and this may increase with the HSCs that norcantharidin is activated by suppression Value is with to promote that its apoptosis realizes the effect of hf resi stant relevant, and cantharidin receives collagen fiber in also solubilized absorbs liver, improves HF.

At present, medicinal vesiculation medicine is generally single medicine, and acts on single, and the good herbal mixture of existing effect cannot Carry out coordinating treating with Medicinal Vesiculation Therapy so that Medicinal Vesiculation Therapy fails to represent potential effect in terms for the treatment of hepatopathy, also makes simultaneously Obtaining herbal mixture and rest in the traditional treatment means such as oral, external, general curative effect is general, and patient compliance is poor.

Summary of the invention

In view of this, the technical problem to be solved is to provide a kind of Chinese medicine composition, uses Medicinal Vesiculation Therapy, energy Enough significantly alleviate, eliminate or improve a series of uncomfortable diseases caused by hepatopathy, from root, eliminate the poison such as internal ecchymosis, humidity Disease, improves body immunity, strengthens the human body resistivity to disease, thus realizes fundamentally treating alcoholic liver, Chronic Liver The purpose of the hepatopathys such as inflammation, hepatic fibrosis and liver cirrhosis.

For achieving the above object, the technical solution adopted in the present invention is:

A kind of Chinese medicine composition treating hepatopathy, is made up of the raw material of following weight portion: Radix Puerariae 10 ~ 20 parts, the Rhizoma Anemarrhenae 7 ~ 15 parts, wood 5 ~ 10 parts of melon, Herba Schizonepetae 5 ~ 15 parts, Radix Saposhnikoviae 5 ~ 15 parts, Herba Ranunculi Japonici 10 ~ 20 parts, Cortex Phellodendri 5 ~ 12 parts, Rhizoma Coptidis 10 ~ 15 parts, Sanguis Draxonis 5 ~ 15 parts, Radix Notoginseng 1 ~ 7 part, Aerugo 1 ~ 5 part, 5 ~ 15 parts of Flos Carthami, Ovum Anas domestica 3 ~ 10 parts, Herba Artemisiae Annuae 3 ~ 12 parts, Cortex Dictamni 1 ~ 5 part, Oleum menthae 5 ~ 15 Part.

Preferably, the Chinese medicine composition of described treatment hepatopathy, it is made up of the raw material of following weight portion: Radix Puerariae 12 ~ 15 parts, know Female 8 ~ 12 parts, Fructus Chaenomelis 6 ~ 8 parts, Herba Schizonepetae 8 ~ 12 parts, Radix Saposhnikoviae 10 ~ 15 parts, Herba Ranunculi Japonici 12 ~ 15 parts, Cortex Phellodendri 6 ~ 10 parts, Rhizoma Coptidis 10 ~ 12 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Notoginseng 2 ~ 5 parts, Aerugo 3 ~ 5 parts, 10 ~ 15 parts of Flos Carthami, Ovum Anas domestica 5 ~ 8 parts, Herba Artemisiae Annuae 5 ~ 10 parts, Cortex Dictamni 2 ~ 4 Part, Oleum menthae 8 ~ 12 parts.

Preferably, the Chinese medicine composition of described treatment hepatopathy, it is made up of the raw material of following weight portion: Radix Puerariae 12 parts, the Rhizoma Anemarrhenae 10 parts, Fructus Chaenomelis 8 parts, Herba Schizonepetae 10 parts, Radix Saposhnikoviae 12 parts, Herba Ranunculi Japonici 15 parts, Cortex Phellodendri 8 parts, Rhizoma Coptidis 10 parts, Sanguis Draxonis 12 parts, Radix Notoginseng 4 parts, copper Green 4 parts, 12 parts of Flos Carthami, Ovum Anas domestica 6 parts, Herba Artemisiae Annuae 8 parts, Cortex Dictamni 3 parts, Oleum menthae 10 parts.

The preparation method of the Chinese medicine composition of a kind of above-mentioned treatment hepatopathy, comprises the steps:

Step S1: weigh Herba Schizonepetae, Radix Saposhnikoviae, Cortex Phellodendri, Rhizoma Coptidis, Sanguis Draxonis, Radix Notoginseng, Aerugo, Flos Carthami, Ovum Anas domestica, Herba Artemisiae Annuae, shaggy-fruited dittany respectively Skin, Radix Puerariae, the Rhizoma Anemarrhenae and Fructus Chaenomelis, mixing, boiling, the quality of the volume added water and described Chinese medicine composition is with 20 ~ 30ml:1g Measure；

Step S2: first intense fire decocts 10 ~ 20 minutes, and then slow fire boiling 30 ~ 50 minutes, filtered while hot, obtain decocting liquid；

Step S3: gained decocting liquid is carried out concentrating under reduced pressure, temperature is 50 ~ 80 DEG C, and pressure is 5 ~ 10kPa, obtains extractum, described leaching The relative density of cream is 1.3 ~ 1.5；

Step S4: mashed by Herba Ranunculi Japonici, adds Oleum menthae, mixs homogeneously with described extractum, obtain mastic.

The preparation method of the Chinese medicine composition of a kind of above-mentioned treatment hepatopathy, comprises the following steps:

Step S1: weigh respectively Herba Schizonepetae, Radix Saposhnikoviae, Herba Ranunculi Japonici, Cortex Phellodendri, Rhizoma Coptidis, Sanguis Draxonis, Radix Notoginseng, Aerugo, Flos Carthami, Ovum Anas domestica, Herba Artemisiae Annuae, Cortex Dictamni, Oleum menthae, Radix Puerariae, the Rhizoma Anemarrhenae and Fructus Chaenomelis, mixing, boiling, the volume added water and the quality of described Chinese medicine composition Measure with 15 ~ 25ml:1g；

Step S2: first intense fire decocts 10 ~ 15 minutes, and then slow fire boiling 30 ~ 40 minutes, filtered while hot, obtain decocting liquid；

Step S3: gained decocting liquid is carried out concentrating under reduced pressure, temperature is 55 ~ 65 DEG C, and pressure is 5 ~ 6kPa, obtains extractum, described leaching The relative density of cream is 1.1 ~ 1.3；

Step S4: be vacuum dried by described extractum, pulverizes, obtains powder body.

A kind of Chinese medicine preparation treating hepatopathy, with above-mentioned Chinese medicine composition as effective ingredient, is prepared as water preparation, unguentum, powder Agent or tablet.

Preferably, the Chinese medicine composition of described treatment hepatopathy, also include the raw material II of following weight portion: Semen Coicis 8 ~ 12 Part, Chinese mugwort bud 8 ~ 12 parts, Rhizoma Dioscoreae 8 ~ 12 parts, Radix Curcumae 8 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, 8 ~ 12 parts of Poria.

Preferably, described raw material II is prepared by following method, particularly as follows: weigh Semen Coicis 8 ~ 12g, Chinese mugwort bud respectively 8 ~ 12g, Rhizoma Dioscoreae 8 ~ 12g, Radix Curcumae 8 ~ 12g, the Rhizoma Atractylodis Macrocephalae 8 ~ 12g and Poria 8 ~ 12g, mixing and water adding, every gram of described raw material adds water 10 ~ 12ml, adds Rhizoma Zingiberis 5g, microwave heating, extracts 2 ~ 3 times, extract 1 ~ 2 hour, united extraction liquid every time, filters, and filtrate is concentrated into When 70 ~ 80 DEG C, relative density is the extractum of 1.17 ~ 1.19；The ethanol that volume fraction is 75 ~ 80% is added molten in described extractum Liquid, stands 20 ~ 24 hours, again filters, and when filtrate is concentrated into 75 DEG C, relative density is the mastic of 1.14 ~ 1.15；By described cream Soma is dry, micronizing, obtains superfine powder.

Herba Schizonepetae: acrid in the mouth, tepor；Return lung, Liver Channel.Cure mainly the scattered wind that induces sweat, rash.For catching a cold, headache, measles, rubella, skin ulcer Infections from the beginning of.Herba Schizonepetae concocting method is: remove impurity, sprays clear water, cleans, runs through, cutting, dry.

Radix Saposhnikoviae: taste acrid, sweet, warm.Return bladder, liver, spleen channel.Cure mainly inducing diaphoresis to dispel wind, win wet, relieving convulsion.Have analgesia, antibacterial, Antipyretic grade acts on.

Herba Ranunculi Japonici: for herb and the root of ranunculaceae plant Herba Ranunculi Japonici, have another name called medicinal vesiculation grass, crude herb moxibustion grass and Mao Qincao etc., acrid in the mouth, property Temperature, poisonous.External can stimulate skin to bubble.Cure mainly dampness removing, detumescence, pain relieving, nebula removing, preventing the attack (or recurrence) of malaria, parasite killing.For having a stomachache, jaundice, Malaria, tuberculous lymphadenitis, pterygium, corneal nebula, maggot of going out, infanticide Jue.Compendium of Material Medica says that " alpine rush or palm-bark rain cape is the Seedling of Radix Aconiti Kusnezoffii, custom Name Mao Quan, like water an aromatic plant metioned in ancient books, hairiness is also, and Cai Qiye rubs by the area on the wrist over the radial artery where the pulse is felt for diagnosis position, i.e. foams a night as fire burns, therefore exhales as medicinal vesiculation or crude herb moxibustion.” Load " recluse's preventing the attack (or recurrence) of malaria, burned by patch the area on the wrist over the radial artery where the pulse is felt for diagnosis, night work's bubble fire such as by picking leaves again.

Cortex Phellodendri: for rutaceae Cortex Phellodendri or the bark of wampee.Bitter in the mouth, cold；Cure mainly heat clearing away, dampness, pathogenic fire purging, removing toxic substances. Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice, flaccidity, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, mouth The raw skin ulcer of tongue, sore swollen toxin.Containing more berberine in Cortex Phellodendri, it is possible to the most antibacterial.In vitro tests to staphylococcus aureus, Streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium (except Song Nei Shi) etc. are the most effective.

Rhizoma Coptidis: for the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.Cure mainly heat clearing and damp drying, pathogenic fire purging solution Poison.There is the multiple efficacies such as antibacterial, infection, anti-inflammatory.Use compounding with Rhizoma Coptidis, can improve antibacterial effect.

Sanguis Draxonis: have another name called Caulis Sargentodoxae, for the stem of plants of Lardizabalaceae Caulis Sargentodoxae.Cure mainly promoting blood circulation to restore menstrual flow, expelling wind and removing dampness.According to " China Book on Chinese herbal medicine " to record, Sanguis Draxonis contains rheum emodin, physcione, cupreol, daucosterol, stearic acid, salidroside, dextrorotation Flos Caryophylli resin The compositions such as phenol diglucoside, have a certain impact to cardiovascular tool.

Radix Notoginseng: for the dry root of panax araliaceae plant.Cure mainly dissipating blood stasis hemostasis, subduing swelling and relieving pain.For spitting blood, spit blood, nosebleed Blood, has blood in stool, metrorrhagia, traumatic hemorrhage, and chest and abdomen twinge, tumbling and swelling.Pharmacological research shows, Radix Notoginseng tuber fluid extract can shorten Rabbit blood setting time, has anastalsis；There are increase coronary artery blood flow, decreased heart rate, reduce the work of myocardial oxygen consumption With, and the effect because the blood pressure caused by pituitrin raises, coronary artery shrinks can be resisted.

Aerugo: the basic copper carbonate generated for copper oxidation or natural malachite, main containing basic copper carbonate.Sour-puckery flavor, flat, Poisonous.Cure mainly nebula removing, removing the necrotic tissue, sore, parasite killing, tell wind-phlegm.Control corneal nebula, marginal blepharitis eye, cellulitis, hemorrhoid malignant boil, sore throat, ulcerative gingivitis, ecthyma, Stubborn dermatitis, wind-phlegm apoplexy.Become copper ion after Aerugo and other substance reactions, make antibacterial internal protein degeneration, so that bacterial body Dead.

Flos Carthami: for the dry flower of feverfew Flos Carthami.Cure mainly promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, have difficult labour, extremely Tire, disease that postpartum lochia can't go, blood stasis have a pain, carbuncle, injury from falling down.

Ovum Anas domestica: have another name called Fructus Bruceae, for the fruit of quassia Fructus Bruceae.Bitter in the mouth；Cold in nature；Mild toxicity.Cure mainly heat clearing away；Solve Poison；Parasite killing；Preventing the attack (or recurrence) of malaria." Records of Tradition Chinese and Western Medicine in Combination " is recorded, Fructus Bruceae, and property is apt to cooling blood for hemostasis, and holding concurrently can blood stasis dispersing and fresh blood promoting.

Herba Artemisiae Annuae: taste bitter, acrid, cold.Curing mainly heat clearing away, expelling summer-heat, except steaming.Containing amaroid, volatile oil and abrotine, vitamin A. " China's book on Chinese herbal medicine " is recorded, and Herba Artemisiae Annuae decocting liquid has stronger pressing down to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium Bacterium effect, also has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc..Arteannuin Myocardial contraction can be suppressed with decreased heart rate, reduce coronary flow.

Cortex Dictamni: the dry root bark of rutaceae shaggy-fruited dittany.Bitter in the mouth；Salty；Cold.Cure mainly heat clearing and damp drying；Dispelling wind for relieving itching；Solve Poison.Rubella caused by the hot noxious dampness of main air；Eczema；Scabies；Jaundice；Damp-heat arthralgia.

Oleum menthae: derive from fresh stem and the leaf of Herba Menthae, shines Herba Menthae stem, leaf to half-dried, the most retortable, obtains Oleum menthae. Oleum menthae is pistachio liquid or flaxen supernatant liquid, has strong Herba Menthae fragrance and refrigerant micro-bitterness.Herba Menthae In oil, main constituent is levorotatory menthol content 62.3%-87.2%.Can be used as aromatic drug, remedium corrigens and carminative.For wind heat sense Emit, epidemic febrile disease from the beginning of；Stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest；Headache conjunctival congestion, the disease such as laryngopharynx swelling and pain.

Radix Puerariae: another name Pueraria lobata, Pachyrhizua angulatus, Radix puerariae, Pueraria montana (Lour.) Merr. rattan.Nature and flavor are sweet, pungent, cool；Return spleen, stomach warp；Cure mainly expelling pathogenic factors from muscles for reducing heat, raw Tianjin, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels；High blood Pressure neck pain.

The Rhizoma Anemarrhenae: another name mother, even mother, wild knotweed, L.Lucidus Turcz..Nature and flavor are bitter, cold；Return lung, stomach, kidney channel；Clearing away heat-fire, YIN nourishing is moistened Dry；Curing mainly calentura excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat quenches one's thirst, dryness of the intestine constipation.

Fructus Chaenomelis: another name chaenomeles lagenaria, iron pin pear, wrinkled papaya, Fructus Chaenomelis；Clean, shave after running through or steaming, shine Dry.Nature and flavor acid, temperature；Return liver, spleen channel；Cure mainly suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, waist knee joint acid weight pain, tell Rush down convulsion, tinea pedis edema.

Compared with prior art, beneficial effects of the present invention is as follows:

1) present invention applicant deeply has research to Medicinal Vesiculation Therapy, and proposes one by practice the most among the people and can treat hepatopathy Medicinal vesiculation Chinese medicine composition.The present invention is with theory of Chinese medical science for instructing, in line with the principle of " treatment must aim at the pathogenesis of disease ", by the principle for the treatment of by oral administration of medicines external treatment It is mutually communicated, it is achieved the unification of theory and practice.The present invention is worked in coordination with by medicine, eliminates internal ecchymosis, humidity etc. from root Toxication, dissolves the stagnant state of the internal stasis of blood, raising human body immunity, and combines the unique advantage of Medicinal Vesiculation Therapy, and research treats repeatedly Medicament, is allowed to produce adequate stimulus with skin, improves cutaneous permeability, make the property of medicine enter space between skin and muscles from pore, stimulate the menstrual flow and pass through network, through Focus, strengthens the human body resistivity to disease, thus reaches thoroughly to treat the purpose of hepatopathy.

2) Chinese medicine composition coordinated of the present invention, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, strengthening vital QI to eliminate pathogenic factors, dampness removing reduces phlegm, and coordinates sky Moxibustion therapy, degree of having held up of dispelling, brings out the best in each other, gives full play to function of human body, change the stagnant state of the internal stasis of blood, get rid of internal hundred poison, improve Body immunity, strengthens the human body resistivity to disease.

3) scientific formula of the present invention, compatibility is reasonable, and all medicines are worked in coordination with, strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease.And, the present invention makes It is that Chinese medicine composition is coated with/spreads on affected part or acupuncture point by method so that it is local skin is scorching hot, flushing, followed by bubbles, in conjunction with sky Moxibustion therapy, is expanded by the pore of skin surface, strengthens the rapid osmotic of drug molecule, and/or by acupuncture point to medicine outside Quick property, amplification and storage characteristics and the two-ways regulation at acupuncture point, it is achieved acupuncture and the synergy of medicine, make drug molecule energy Enough go directly focus.The traditional Chinese medical science is thought, the generation of various diseases, is all owing to paathogenic factor acts on human body, causes yin-Yang, gas Blood, internal organs, meridian function activity are not normal, cause caused by the destruction of organismic internal environment relative balance state.Chinese medicine composition of the present invention Thing coordinates medicinal vesiculation can adjust body's immunity and inherent balance, the resistance against diseases of enhancing body, fundamentally improves hepatopathy Symptom, plays a multiplier effect.

4) bound drug characteristic of the present invention and Medicinal Trait, preparation method is simple, it is easy to operation, and universality is wide, gained medicine Thing is evident in efficacy, it is easy to be fabricated to the medicine for external use of different dosage form.

5) present invention uses using Semen Coicis, Chinese mugwort bud, Rhizoma Dioscoreae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae and Poria as oral formulations collocation medicinal vesiculation, mouth Formulation is vacuum-packed with the form of superfine powder, is directly dissolved in water during use, one bag of superfine powder 10 ~ 12g, once Rush 200ml to be directly administered orally.Wherein, Semen Coicis, Chinese mugwort bud, Rhizoma Dioscoreae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae and Poria compatibility are suitable, are carried by proper method Taking, oral have invigorating the stomach and promoting digestion, and suppressing the hyperactive liver is regulated the flow of vital energy, and the effect of regulation immunity coordinates with Medicinal Vesiculation Therapy, is more beneficial for conditions of patients Fast quick-recovery, reaches the purpose for the treatment of both the principal and secondary aspects of a disease.

Detailed description of the invention

In order to be more fully understood that the present invention, fairly set out present disclosure further below in conjunction with embodiment, but this Bright protection content is not limited solely to the following examples.In the following description, give a large amount of concrete details so that More thorough understanding of the invention is provided.It will be apparent, however, to one skilled in the art that the present invention is permissible It is carried out without these details one or more.

Embodiment 1: a kind of Chinese medicine composition treating hepatopathy, is made up of the raw material of following weight: Herba Schizonepetae 10 parts, Radix Saposhnikoviae 12 parts, Herba Ranunculi Japonici 15 parts, Cortex Phellodendri 8 parts, Rhizoma Coptidis 10 parts, Sanguis Draxonis 12 parts, Radix Notoginseng 4 parts, Aerugo 4 parts, 12 parts of Flos Carthami, Ovum Anas domestica 6 Part, Herba Artemisiae Annuae 8 parts, Cortex Dictamni 3 parts, Oleum menthae 10 parts, Radix Puerariae 12 parts, the Rhizoma Anemarrhenae 10 parts, Fructus Chaenomelis 8 parts.

Embodiment 2: a kind of Chinese medicine composition treating hepatopathy, is made up of the raw material of following weight: Herba Schizonepetae 8 parts, Radix Saposhnikoviae 10 parts, Herba Ranunculi Japonici 12 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 12 parts, Sanguis Draxonis 10 parts, Radix Notoginseng 2 parts, Aerugo 3 parts, 10 parts of Flos Carthami, Ovum Anas domestica 5 Part, Herba Artemisiae Annuae 5 parts, Cortex Dictamni 2 parts, Oleum menthae 8 parts, Radix Puerariae 14 parts, the Rhizoma Anemarrhenae 8 parts, Fructus Chaenomelis 6 parts.

Embodiment 3: a kind of Chinese medicine composition treating hepatopathy, is made up of the raw material of following weight: Herba Schizonepetae 12 parts, Radix Saposhnikoviae 15 parts, Herba Ranunculi Japonici 14 parts, Cortex Phellodendri 10 parts, Rhizoma Coptidis 10 parts, Sanguis Draxonis 15 parts, Radix Notoginseng 5 parts, Aerugo 5 parts, 15 parts of Flos Carthami, Ovum Anas domestica 8 Part, Herba Artemisiae Annuae 10 parts, Cortex Dictamni 4 parts, Oleum menthae 12 parts, Radix Puerariae 15 parts, the Rhizoma Anemarrhenae 12 parts, Fructus Chaenomelis 7 parts.

Embodiment 4: a kind of Chinese medicine composition treating hepatopathy, is made up of the raw material of following weight: Herba Schizonepetae 15 parts, Radix Saposhnikoviae 8 parts, Herba Ranunculi Japonici 20 parts, Cortex Phellodendri 12 parts, Rhizoma Coptidis 15 parts, Sanguis Draxonis 8 parts, Radix Notoginseng 7 parts, Aerugo 2 parts, 8 parts of Flos Carthami, Ovum Anas domestica 10 Part, Herba Artemisiae Annuae 12 parts, Cortex Dictamni 5 parts, Oleum menthae 15 parts, Radix Puerariae 20 parts, the Rhizoma Anemarrhenae 15 parts, Fructus Chaenomelis 10 parts.

Embodiment 5: a kind of Chinese medicine composition treating hepatopathy, is made up of the raw material of following weight: Herba Schizonepetae 5 parts, Radix Saposhnikoviae 5 parts, Herba Ranunculi Japonici 10 parts, Cortex Phellodendri 5 parts, Rhizoma Coptidis 10 parts, Sanguis Draxonis 5 parts, Radix Notoginseng 1 part, Aerugo 1 part, 5 parts of Flos Carthami, Ovum Anas domestica 3 parts, Herba Artemisiae Annuae 3 parts, Cortex Dictamni 1 part, Oleum menthae 5 parts, Radix Puerariae 10 parts, the Rhizoma Anemarrhenae 7 parts, Fructus Chaenomelis 5 parts.

Embodiment 6: a kind of Chinese medicine composition treating hepatopathy, is made up of the raw material of following weight: Herba Schizonepetae 10 parts, Radix Saposhnikoviae 12 parts, Herba Ranunculi Japonici 15 parts, Cortex Phellodendri 8 parts, Rhizoma Coptidis 10 parts, Sanguis Draxonis 12 parts, Radix Notoginseng 4 parts, Aerugo 4 parts, 12 parts of Flos Carthami, Ovum Anas domestica 6 Part, Herba Artemisiae Annuae 8 parts, Cortex Dictamni 3 parts, Oleum menthae 10 parts, Radix Puerariae 12 parts, the Rhizoma Anemarrhenae 10 parts, Fructus Chaenomelis 8 parts, Rhizoma Chuanxiong 7 parts.

The present embodiment increases Rhizoma Chuanxiong a herb, and Rhizoma Chuanxiong is warm in nature, acrid in the mouth, returns liver, gallbladder, pericardium channel, has blood-activating and qi-promoting, dispels The merit of wind pain relieving, works in coordination with compatibility with Sanguis Draxonis, Radix Notoginseng, Flos Carthami and Ovum Anas domestica, strengthens effect of we's blood circulation promoting and blood stasis dispelling, strengthens blood and follows Ring, feeds nutrition, improves therapeutic efficiency.

Embodiment 7: the preparation of water preparation

The preparation method of water preparation, comprises the following steps:

Step S1: weigh Herba Schizonepetae 10g, Radix Saposhnikoviae 12g, Herba Ranunculi Japonici 15g, Cortex Phellodendri 8g, Rhizoma Coptidis 10g, Sanguis Draxonis 12g, Radix Notoginseng 4g, Aerugo 4g, The sub-6g of Flos Carthami 12g, Ovum Anas domestica, Herba Artemisiae Annuae 8g, Cortex Dictamni 3g, Oleum menthae 10g, Radix Puerariae 12g, Rhizoma Anemarrhenae 10g, Fructus Chaenomelis 8g, mixing, add decocting Boiling, the volume added water measures with 20ml:1g with the quality of described Chinese medicine composition；

Step S2: first intense fire decocts 12 minutes, and then slow fire boiling 35 minutes, filtered while hot, obtain decocting liquid.

Described decocting liquid is cooled down, directly can use as water preparation.By water preparation sterile storage in spray bottle, spraying uses more Convenient.

Embodiment 8: the preparation of unguentum

The preparation method of unguentum comprises the steps:

Step S1: weigh Herba Schizonepetae 10g, Radix Saposhnikoviae 12g, Herba Ranunculi Japonici 15g, Cortex Phellodendri 8g, Rhizoma Coptidis 10g, Sanguis Draxonis 12g, Radix Notoginseng 4g, Aerugo 4g, The sub-6g of Flos Carthami 12g, Ovum Anas domestica, Herba Artemisiae Annuae 8g, Cortex Dictamni 3g, Oleum menthae 10g, Radix Puerariae 12g, Rhizoma Anemarrhenae 10g, Fructus Chaenomelis 8g, mixing, add decocting Boiling, the volume added water measures with 25ml:1g with the quality of described Chinese medicine composition；

Step S2: first intense fire decocts 10 minutes, and then slow fire boiling 40 minutes, filtered while hot, obtain decocting liquid；

Step S3: gained decocting liquid is carried out concentrating under reduced pressure, temperature is 65 DEG C, and pressure is 5kPa, obtains extractum, the phase of described extractum It is 1.2 to density.

Gained extractum directly can use as unguentum.

Embodiment 9: the preparation of unguentum

The preparation method of unguentum, comprises the steps:

Step S1: weigh Herba Schizonepetae 10g, Radix Saposhnikoviae 12g, Cortex Phellodendri 8g, Rhizoma Coptidis 10g, Sanguis Draxonis 12g, Radix Notoginseng 4g, Aerugo 4g, Flos Carthami 12g, The sub-6g of Ovum Anas domestica, Herba Artemisiae Annuae 8g, Cortex Dictamni 3g, Oleum menthae 5g, Radix Puerariae 12g, Rhizoma Anemarrhenae 10g, Fructus Chaenomelis 8g, mixing, boiling, add water Volume measures with 25ml:1g with the quality of described Chinese medicine composition；

Step S2: first intense fire decocts 15 minutes, and then slow fire boiling 45 minutes, filtered while hot, obtain decocting liquid.

Step S3: gained decocting liquid is carried out concentrating under reduced pressure, temperature is 70 DEG C, and pressure is 8kPa, obtains extractum, described extractum Relative density be 1.4；

Step S4: weigh Herba Ranunculi Japonici 15g and mash, adds Oleum menthae 5g, mixs homogeneously with described extractum, obtain mastic.

Gained mastic then directly can use as unguentum.

Embodiment 10: the preparation of powder

The preparation method of powder, comprises the following steps:

Step S1: weigh Herba Schizonepetae 10g, Radix Saposhnikoviae 12g, Herba Ranunculi Japonici 15g, Cortex Phellodendri 8g, Rhizoma Coptidis 10g, Sanguis Draxonis 12g, Radix Notoginseng 4g, Aerugo 4g, The sub-6g of Flos Carthami 12g, Ovum Anas domestica, Herba Artemisiae Annuae 8g, Cortex Dictamni 3g, Oleum menthae 10g, Radix Puerariae 12g, Rhizoma Anemarrhenae 10g, Fructus Chaenomelis 8g, mixing, add decocting Boiling, the volume added water measures with 15ml:1g with the quality of described Chinese medicine composition；

Step S2: first intense fire decocts 20 minutes, and then slow fire boiling 30 minutes, filtered while hot, obtain decocting liquid.

Step S3: gained decocting liquid is carried out concentrating under reduced pressure, temperature is 60 DEG C, and pressure is 6kPa, obtains extractum, described extractum Relative density be 1.3；

Gained powder body in use, need to be diluted to solution shape with sterilized water or ethanol, then smear.

Embodiment 11: the preparation of tablet

The preparation method of tablet, comprises the steps:

Step S1 ~ S3 is with embodiment 10；

Step S4: it is 1 ~ 2 millimeter, the tablet of a diameter of 0.5 ~ 1 centimetre that described extractum is made thickness.

A kind of Chinese medicine preparation addressed of the present invention, with above-mentioned Chinese medicine composition as effective ingredient, is prepared as water preparation, cream Agent, powder or tablet, preferably water preparation.

The present invention not can be prepared the exhaustive of dosage form by above-mentioned dosage form, according to the present invention and common process, art technology Personnel can be by the pharmaceutical composition of the present invention by being together formulated as suitable agent with suitable carrier, excipient and diluent Type.Described dosage form can also be the form of pill, powder, tincture, suspensoid, Emulsion or aerosol.Described suitable load The example of body, excipient and diluent is starch, sucrose, lactose, glucose, gelatin, sorbitol, mannitol, calcium silicates, fiber Element, methylcellulose, microcrystalline Cellulose, polyvinylpyrrolidone, water, methyl hydroxybenzoate, propyl hydroxybenzoate, Talcum, magnesium stearate and Mineral oil.Described dosage form also can comprise additionally in filler, anti-agglutinant, disintegrating agent, fluidizer, wetting agent, emulsifying agent, prevent Rotten agent etc..

Embodiment 12: oral formulations

The present invention treats the Chinese medicine composition of hepatopathy, also includes the raw material II of following weight portion: Semen Coicis 10g, Chinese mugwort bud 10g, mountain Medicine 10g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 10g and Poria 10g.

Described in the present embodiment, raw material II is prepared as oral formulations by following method, particularly as follows: weigh Semen Coicis respectively 10g, Chinese mugwort bud 10g, Rhizoma Dioscoreae 10g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 10g and Poria 10g, mixing and water adding, every gram of raw material adds water 10ml, adds Rhizoma Zingiberis Recens Sheet 5g, microwave heating, to extract 2 times, extract 1.5 hours, united extraction liquid every time, filter, filtrate is concentrated into when 75 DEG C the closeest Degree is the extractum of 1.18；Adding volume fraction in described extractum is the ethanol solution of 75%, stands 24 hours, again filters, filter When liquid is concentrated into 75 DEG C, relative density is the mastic of 1.15；Described mastic is dried, micronizing, obtains superfine powder.

Superfine powder is carried out vacuum bagging, the most packed 10 ~ 12g.During use, one bag of superfine powder adds 200ml water dissolution, is Oral formulations.

Wherein, the favourable water penetration of Semen Coicis is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, the effect of detoxicating and resolving stagnation of pathogens.Chinese mugwort bud takes from Chinese mugwort The fresh bud point of grass, pluck in the Ching Ming Festival after in 15 days；There is bitter dry pungent dissipate, it is possible to warming the meridian arteries and veins, blood of regulating the flow of vital energy, only cold type of pain, by cold Many effects such as wet.Rhizoma Dioscoreae, has nourishing strong, aid digestion, holds back sweating due to debility, effect of antidiarrheal.Radix Curcumae, promoting blood circulation and stopping pain, circulation of qi promoting solution Strongly fragrant, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.The Rhizoma Atractylodis Macrocephalae, has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Poria, has diuretic Eliminating dampness by diuresis, spleen invigorating, effect of mind calming.Rhizoma Zingiberis has function of gallbladder promoting, arresting vomiting by invigorating the stomach, wards off effect stench, anthydropic, obvious health-care efficacy. The same use of said medicine, has invigorating the stomach and promoting digestion, and suppressing the hyperactive liver is regulated the flow of vital energy, effect of regulation immunity, uses suitable preparation method to be lived by medicine Property constituents extraction obtains more abundant.

In the present invention, the power of microwave heating is preferably 350 ~ 400W, and heating-up temperature is 70 ~ 80 DEG C, passes through microwave heating It is more beneficial for infiltration and the extraction of Chinese medicine.

The need of using oral formulations to carry out dialectical treating with patient self symptom, and not all patient is required for coordinating Oral.Certainly for the patient of serious symptom, it is administered orally and is more beneficial for its self function of recovery, accelerate therapeutic efficiency.

Embodiment 13

The present invention treats the Chinese medicine composition of hepatopathy, also includes the raw material II of following weight portion: Semen Coicis 12g, Chinese mugwort bud 10g, mountain Medicine 10g, Radix Curcumae 8g, Rhizoma Atractylodis Macrocephalae 12g and Poria 10g.

Described in the present embodiment, raw material II is prepared as oral formulations by following method, particularly as follows: weigh Semen Coicis respectively 12g, Chinese mugwort bud 10g, Rhizoma Dioscoreae 10g, Radix Curcumae 8g, Rhizoma Atractylodis Macrocephalae 12g and Poria 10g, mixing and water adding, every gram of raw material adds water 12ml, adds Rhizoma Zingiberis Recens Sheet 5g, microwave heating, extracts 3 times, extracts 2 hours, united extraction liquid every time, filter, relative density when filtrate is concentrated into 78 DEG C It is the extractum of 1.19；Adding volume fraction in described extractum is the ethanol solution of 80%, stands 22 hours, again filters, filtrate When being concentrated into 75 DEG C, relative density is the mastic of 1.14；Described mastic is dried, micronizing, obtains superfine powder.

Below by embodiment 7 preparation water preparation as a example by illustrate Chinese medicine composition of the present invention using method, specifically include as Lower step:

1) by water preparation even application at skin surface or acupuncture point, pat a moment, position parcel will be smeared with sterile film, carry out solid Fixed；2) after 10 ~ 20 minutes, patient can feel local causalgia, formication, erubescence；In 3 days, patient skin gradually rises Bubble, in blister, liquid is full, distension time, use Medicinal Vesiculation Therapy, by liquid sucking-off in above-mentioned blister；3) after moxibustion terminates, right Foamed position carries out appropriateness and disinfects.

Said method treatment is once 1 course for the treatment of, according to the order of severity of the state of an illness, within one week, offers free medical treatment 1 ~ 2 time, follows the doctor's advice.

Medicinal vesiculation medicament of the present invention carries out antibacterial with medicine itself, anti-infection, compared with existing medicinal vesiculation medicament, without any Chemical reagent, to skin avirulence, and infectious effect antibacterial, anti-is excellent, it is not necessary to worry foamed position infection problems；The present invention Operating process is the most simpler, it is easy to control, it might even be possible to treatment of being in voluntarily.

Medicinal Vesiculation Therapy makes medicine act on the physical property stimulation that skin surface produces, and then stimulates human collateral channel system, draws Play sympathetic nerve reflection disperse so that the regulation of meridians internal organs function, play therapeutical effect.Long-term practice shows, the present invention is led to Crossing to sting the skin zone of clear body surface and combine sky and process the effect of medicine, treat hepatopathy from root, curative effect is more thorough, and the course for the treatment of is shorter, effect Fruit is excellent.And, percutaneous dosing has the particular advantages surmounting general medication, can be without " first pass effect " of liver Destroy with gastrointestinal, and skin interbed also have storage effect, make drug concentration profile mild, it is to avoid peak valley phenomenon, it is provided that Can be predetermined and longer action time, maintain that to stablize lasting blood drug level, toxicity and untoward reaction little, easy to use, patch Deposited person can be with self-administration with stop medication at any time.

1, the observation of curative effect of Chinese medicine composition of the present invention

Observe case to be complete during the December of in December, 2012 ~ 2015 year the alcoholic liver patient of the corresponding treatment course for the treatment of；Sight can be listed in That examines has 200 examples.

Therapeutic Method: method I: use water preparation of the present invention to treat with Medicinal Vesiculation Therapy, 1 ~ 2 time weekly, uses 2 continuously Month.Method II: use water preparation of the present invention to treat with Medicinal Vesiculation Therapy, with method I；Take oral formulations, each medicinal vesiculation simultaneously Therapy coordinates a secondary oral formulations 200ml.200 example patients are randomly divided into two groups, and employing method I treats 120 examples, uses method II treatment 80 examples, there was no significant difference between two groups.

Curative effect judgment criteria: " the alcoholic liver disease diagnosis guide " of revision is drafted according in January, 2010.Effective: conscious disease Shape significantly improves, and ascites disappears completely, and TBil, DBil and ALT reach or after the treatment close to normal；Effective: subjective symptoms has To a certain degree improving, ascites significantly reduces more than 60%, and TBil, DBil and ALT decrease beyond more than 60% after the treatment；Invalid: Effective standard it is not up to after treatment.

Statistical result: the present invention achieves extraordinary curative effect clinically, in 200 example alcoholic liver patients, employing side In 120 example patients of method I treatment, effective 109 examples, obvious effective rate accounts for 90.8%；Effective 11 examples, total effective rate is 100%.Employing method In 80 example patients of II treatment, effective 79 examples, obvious effective rate is 98.8%；Effective 1 example, total effective rate is 100%.

By above-mentioned observation of curative effect it will be seen that the total effective rate of employing method I and method II treatment is 100%, difference : using Therapeutic Method II to be more beneficial for the recovery from illness of patient, obvious effective rate is slightly higher.Additionally, the treatment that applicant is to recovery from illness patient Time has carried out comparison, finds to use Therapeutic Method II to treat, and the course for the treatment of of patient can shorten the time of 1 ~ 2 course for the treatment of.

Additionally, the present invention is to effect also highly significants such as treatment hepatic fibrosis, liver cirrhosis and chronic hepatitiss.Applicant adds up Completing the case for the treatment of during the December of in December, 2012 ~ 2015 year, only with Medicinal Vesiculation Therapy, statistical result is: treat chronic Hepatitis 93 example, effective 85 examples, effective 6 examples, total effective rate is 100%；Treatment patients with liver fibrosis 102 example, effective 86 examples, Effective 16 examples, total effective rate 100%；Treatment liver cirrhosis patient 69 example, effective 60 examples, effective 9 examples, total effective rate 100%.

2, the clinical observation of Chinese medicine composition of the present invention

Case 1: close certain, man, 41 years old, active worker, is on ordinary days addicted to drink, finds alcoholic liver symptom during health check-up, because symptom is inconspicuous not Give treatment, aggravate afterwards, breast the side of body dull pain make swollen, institute's abdominal distention is vexed.Western medical treatment, poor effect, delay and have a surplus for 1 year.Use the present invention Described Chinese medicine composition carries out after Medicinal Vesiculation Therapy treats 6 weeks, and related symptoms disappears substantially, and physical recovery is normal, bright addicted to drink situation Aobvious improvement.

Case 2: Lee, man, 38 years old, active worker, Chronic hepatitis B, more than 5 years, tossed about in bed treatment for many years and has no resolution.Adopt After carrying out Medicinal Vesiculation Therapy treatment 4 months with Chinese medicine composition of the present invention, hepatitis symptom disappears substantially, and liver function recovery is just Often.

Case 3: high certain, female, 52 years old, peasant, suffer from hepatic fibrosis 4 years, the most timely and effective treatment, deteriorate and develop into liver in early days Harden 1 year.Use Chinese medicine composition of the present invention carry out Medicinal Vesiculation Therapy treatment half a year after, hepatocirrhosis symptoms is effectively controlled System, indices controls within normal range, and liver function recovers normal substantially.

Case 4: manage certain, man, 49 years old, active worker, suffers from hepatic fibrosis 1 year, digests bad, fatigue and weak.Use this Bright described Chinese medicine composition carries out after Medicinal Vesiculation Therapy treats 6 weeks, and hepatic fibrosis returns to one's perfect health, and liver function is normal, the most again Recurrence.

Above-mentioned case part the most of the present invention is offered free medical treatment case, and situation is true, is documented in and is merely to illustrate the present invention herein The concrete indication of part, but the invention is not limited in the symptom that above-mentioned case is reflected.Those skilled in the art according to Content herein combines Conventional wisdom and uses it for the treatment of other diseases, is also contained in protection scope of the present invention.

Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, and this area is common Other amendment or equivalents that technical scheme is made by technical staff, without departing from technical solution of the present invention Spirit and scope, all should contain in the middle of scope of the presently claimed invention.

Claims

1. the Chinese medicine composition treating hepatopathy, it is characterised in that: it is made up of the raw material of following weight portion: Radix Puerariae 10 ~ 20 parts, The Rhizoma Anemarrhenae 7 ~ 15 parts, Fructus Chaenomelis 5 ~ 10 parts, Herba Schizonepetae 5 ~ 15 parts, Radix Saposhnikoviae 5 ~ 15 parts, Herba Ranunculi Japonici 10 ~ 20 parts, Cortex Phellodendri 5 ~ 12 parts, Rhizoma Coptidis 10 ~ 15 Part, Sanguis Draxonis 5 ~ 15 parts, Radix Notoginseng 1 ~ 7 part, Aerugo 1 ~ 5 part, 5 ~ 15 parts of Flos Carthami, Ovum Anas domestica 3 ~ 10 parts, Herba Artemisiae Annuae 3 ~ 12 parts, Cortex Dictamni 1 ~ 5 parts, Oleum menthae 5 ~ 15 parts.

2. the Chinese medicine composition treating hepatopathy as claimed in claim 1, it is characterised in that: by the raw material system of following weight portion Become: Radix Puerariae 12 ~ 15 parts, the Rhizoma Anemarrhenae 8 ~ 12 parts, Fructus Chaenomelis 6 ~ 8 parts, Herba Schizonepetae 8 ~ 12 parts, Radix Saposhnikoviae 10 ~ 15 parts, Herba Ranunculi Japonici 12 ~ 15 parts, Cortex Phellodendri 6 ~ 10 parts, Rhizoma Coptidis 10 ~ 12 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Notoginseng 2 ~ 5 parts, Aerugo 3 ~ 5 parts, 10 ~ 15 parts of Flos Carthami, Ovum Anas domestica 5 ~ 8 parts, Herba Artemisiae Annuae 5 ~ 10 parts, Cortex Dictamni 2 ~ 4 parts, Oleum menthae 8 ~ 12 parts.

3. the Chinese medicine composition treating hepatopathy as claimed in claim 2, it is characterised in that: by the raw material system of following weight portion Become: Radix Puerariae 12 parts, the Rhizoma Anemarrhenae 10 parts, Fructus Chaenomelis 8 parts, Herba Schizonepetae 10 parts, Radix Saposhnikoviae 12 parts, Herba Ranunculi Japonici 15 parts, Cortex Phellodendri 8 parts, Rhizoma Coptidis 10 parts, Sanguis Draxonis 12 parts, Radix Notoginseng 4 parts, Aerugo 4 parts, 12 parts of Flos Carthami, Ovum Anas domestica 6 parts, Herba Artemisiae Annuae 8 parts, Cortex Dictamni 3 parts, Oleum menthae 10 parts.

4. the preparation method of the Chinese medicine composition of the treatment hepatopathy as described in any one of claim 1 ~ 3, it is characterised in that: Comprise the steps:

5. the preparation method of the Chinese medicine composition of the treatment hepatopathy as described in any one of claim 1 ~ 3, it is characterised in that Comprise the following steps:

6. the Chinese medicine preparation treating hepatopathy, it is characterised in that: with in the treatment hepatopathy described in any one of claim 1 ~ 3 Drug composition is effective ingredient, makes water preparation, unguentum, powder or tablet.

7. the Chinese medicine composition of the treatment hepatopathy as described in any one of claim 1 ~ 3, it is characterised in that: also include following weight The raw material II of part: Semen Coicis 8 ~ 12 parts, Chinese mugwort bud 8 ~ 12 parts, Rhizoma Dioscoreae 8 ~ 12 parts, Radix Curcumae 8 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, Poria 8 ~ 12 Part.

8. the Chinese medicine composition treating hepatopathy as claimed in claim 7, it is characterised in that: described raw material II is by following method Be prepared, particularly as follows: weigh respectively Semen Coicis 8 ~ 12g, Chinese mugwort bud 8 ~ 12g, Rhizoma Dioscoreae 8 ~ 12g, Radix Curcumae 8 ~ 12g, the Rhizoma Atractylodis Macrocephalae 8 ~ 12g and Poria 8 ~ 12g, mixing and water adding, every gram of described raw material adds water 10 ~ 12ml, adds Rhizoma Zingiberis 5g, microwave heating, extracts 2 ~ 3 times, every time Extracting 1 ~ 2 hour, united extraction liquid, filter, when filtrate is concentrated into 70 ~ 80 DEG C, relative density is the extractum of 1.17 ~ 1.19；Institute Stating addition volume fraction in extractum is the ethanol solution of 75 ~ 80%, stands 20 ~ 24 hours, again filters, and filtrate is concentrated into 75 DEG C Time relative density be the mastic of 1.14 ~ 1.15；Described mastic is dried, micronizing, obtains superfine powder.