CN106135274A - A kind of medicated clothing skin degerming agent composition containing iodine and preparation method thereof - Google Patents
A kind of medicated clothing skin degerming agent composition containing iodine and preparation method thereof Download PDFInfo
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- CN106135274A CN106135274A CN201510192722.6A CN201510192722A CN106135274A CN 106135274 A CN106135274 A CN 106135274A CN 201510192722 A CN201510192722 A CN 201510192722A CN 106135274 A CN106135274 A CN 106135274A
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Abstract
The present invention relates to effectively remove medicated clothing and skin surface antibacterial, a kind of medicated clothing skin degerming agent containing iodine that long acting antibiotic protection is provided and preparation method thereof, its composition is divided into A, B two groups, wherein: component A: iodine: 0.1-0.3%, stabilizer: 0.1-0.3%, organic acid: 0.15-0.35%, pure water: 20-35%;B component: surfactant: 9-10%, Organic Alcohol: 60-70%, chelating agent: 0.1-0.3%, pure water: 23-75%.The present invention also provides for a kind of preparing the above-mentioned method containing iodine medicated clothing skin degerming agent.Compared with conventional iodine complex bacteria remover, present invention reduces the valid density of iodine, improve the bactericidal activity of iodine, decrease the iodine zest to skin mucosa, improve the xanthochromia of iodine.Present invention process is simple, and preparation is convenient, it is easy to produces in batches, promote the use of；Can be not only used for the degerming use of resident's daily life, can be widely used for again the personnel specialty washing hands and clothes such as hospital, bank, finance, restaurant, hotel and service occupation and be used.
Description
Technical field
The present invention relates to a kind of can effectively remove medicated clothing and skin surface antibacterial, a kind of medicated clothing skin degerming agent containing iodine that long acting antibiotic protection is provided and preparation method thereof.
Background technology
Since the scientist of France in 1812 takes the lead in being extracted iodine from the algae in sea, and iodine just sets up their relationship with the mankind.As halogen, iodine has the most excellent bactericidal property.Iodine bacteria remover has wide range of applications.Abroad wash one's hands before surgical operation as skin degerming agent in the sixties.The end of the seventies and the beginning of the eighties, China, on the basis of having carried out antibacterium and viral activity assay, starts the experiment for treating periodontitis and infective wound surface, achieves good effect.So far, the degerming scope of Operand has been directed to the different field such as clinic, health, daily life, agricultural breeding and drinking water.The degerming product of iodine different classes of, different dosage form, different efficacies is just being widely used in practice.The research and development of the degerming preparation of iodine are more easy to industrialization, and developing target market required complex iodine formulations product is by the very big concern of research staff.
Summary of the invention
The present invention solves existing problem, it is desirable to provide a kind of medicated clothing skin degerming agent containing iodine and preparation method thereof.
The present invention provides a kind of medicated clothing skin degerming agent containing iodine, and its composition is divided into A, B two groups, wherein:
Component A:
Iodine: 0.1-0.3%,
Stabilizer: 0.1-0.3%,
Organic acid: 0.15-0.35%,
Pure water: 20-35%;
B component:
Surfactant: 9-10%,
Organic Alcohol: 60-70%,
Chelating agent: 0.1-0.3%,
Pure water: 23-75%.
The present invention also provides for a kind of preparing the above-mentioned method containing iodine medicated clothing skin degerming agent:
In pure water, it is sequentially added into elemental iodine, stabilizer, organic acid with continuous stirring, makes uniform component A；In pure water, add surfactant or Organic Alcohol mix homogeneously with continuous stirring, add chelating agent, make even phase B component；Finally B component is added in component A and stir, obtain the bacteria remover solution of golden transparent.
Wherein, described stabilizer is KI, NaI, KIO3、NaIO3In one or more.
Wherein, described organic acid is one or more in formic acid, acetic acid, citric acid, tartaric acid.
Wherein, described surfactant is the nonionic surfactant of fatty alcohol polyethenoxy ether class.
Wherein, described Organic Alcohol is ethanol.
Wherein, described synergism chelating agent is one or more in biguanides, hyperbranched Gemini quaternary ammonium salt amino-compound.
Compared with conventional iodine complex bacteria remover, present invention reduces the valid density of iodine, improve the bactericidal activity of iodine, decrease the iodine zest to skin mucosa, improve the xanthochromia of iodine.Present invention process is simple, and preparation is convenient, it is easy to produces in batches, promote the use of；Can be not only used for the degerming use of resident's daily life, can be widely used for again the personnel specialty washing hands and clothes such as hospital, bank, finance, restaurant, hotel and service occupation and be used.
Detailed description of the invention
Below in conjunction with embodiment, the specific implementation method of the present invention is further described.This embodiment is for clearly illustrating technical scheme, and can not limit the scope of the invention with this.
Embodiment one:
Component A: iodine: 0.3%；
Stabilizer: 0.3%；
Organic acid: 0.15%；
Pure water 25%.
As preferably, the stabilizer that the present embodiment is used is KI, but KI, NaI, KIO3、NaIO3In one or more all can reach close effect, industry technical staff can be according to practical situation flexible Application.
As preferably, the organic acid that the present embodiment is used is formic acid, but one or more in formic acid, acetic acid, citric acid, tartaric acid all can reach close effect, and industry technical staff can be according to practical situation flexible Application.
B component: Organic Alcohol 73.95%；
Chelating agent 0.3%；
At a temperature of 50 DEG C, in the pure water of continuous stirring, it is sequentially added into stabilizer, iodine, organic acid, insulated and stirred 30min, prepares the component A of even phase.
At a temperature of 50 DEG C, in organic alcohol phase of continuous stirring, add chelating agent, insulated and stirred 30min, prepare the B component of even phase.
At a temperature of 50 DEG C, B component is added in component A, stir, obtain stable golden transparent solution.
Organic Alcohol used in this specific embodiment is ethanol, and as solvent, owing to using dosage is relatively big, the bigger alcohols material of other toxicity is not in spendable scope.
As preferably, the chelating agent that the present embodiment is used is biguanides amino-compound, but one or more in biguanides, hyperbranched Gemini quaternary ammonium salt amino-compound all can reach close effect, and industry technical staff can be according to practical situation flexible Application.
As preferably, the surfactant that the present embodiment is used is the nonionic surfactant of fatty alcohol polyethenoxy ether class.
Embodiment two
Component A: iodine: 0.3%；
Stabilizer: 0.5%；
Organic acid: 0.2%；
Pure water: 20%.
As preferably, the stabilizer that the present embodiment is used is KI, but KI, NaI, KIO3、NaIO3In one or more all can reach close effect, industry technical staff can be according to practical situation flexible Application.
As preferably, the organic acid that the present embodiment is used is formic acid, but one or more in formic acid, acetic acid, citric acid, tartaric acid all can reach close effect, and industry technical staff can be according to practical situation flexible Application.
B component: surfactant: 9%；
Chelating agent: 0.2%；
Pure water: 69.8%.
At a temperature of 50 DEG C, in the pure water of continuous stirring, it is sequentially added into stabilizer, iodine, organic acid, insulated and stirred 30min, prepares the component A of even phase.
At a temperature of 50 DEG C, in the pure water of continuous stirring, it is sequentially added into surfactant, hyperbranched Gemini quaternary ammonium salt amino-compound, insulated and stirred 30min, prepares the B component of even phase.
At a temperature of 50 DEG C, B component is added in component A, stir, obtain stable golden transparent solution.
As preferably, the chelating agent that the present embodiment is used is biguanides amino-compound, but one or more in biguanides, hyperbranched Gemini quaternary ammonium salt amino-compound all can reach close effect, and industry technical staff can be according to practical situation flexible Application.
As preferably, the surfactant that the present embodiment is used is the nonionic surfactant of fatty alcohol polyethenoxy ether class.
It is embodied as each component dose and not only comprises as above numerical value described in two examples, in the range of shown in claims, all can reach identical bactericidal effect.
The using method of above-described embodiment: this product is diluted 100 times, soaks 20min,
Then it is used in mixed way with detergent.
Anemia of pregnant woman uses the most with caution with infant.
The present invention carries and solves elemental iodine distillation water insoluble, easy, easy xanthochromia, has unhappy abnormal smells from the patient and high concentration iodine solution to the defect such as skin mucosa is irritant, by there being the complexing ligand of synergic remove to be coordinated therewith so that it is can be stable in the presence of in solution.Meanwhile, the sterilizing ability of its solution is promoted compared with the iodide ion solution of comparable sodium significantly, the gentleest to skin mucosa.
Iodine as main sterilization component, be a class efficiently, wide spectrum bacteria remover, the pathogen such as antibacterial, brood cell, virus, phage, mycobacteria, protozoon, fungus can be killed.
Surfactant fatty alcohol-polyoxyethylene ether, is a kind of low bubble nonionic surfactant, not only has good clean ability, can effectively remove medicated clothing and skin surface dirt, moreover it is possible to forms complex with iodine, makes iodine be stable in the presence of in solution.
Biguanides, hyperbranched Gemini quaternary ammonium salt amino-compound serve not only as the chelating agent of iodine, can increase iodine stability in the solution, play synergic remove with iodine simultaneously, enhance again the bactericidal activity of iodine.
Organic acid is that chelated iodine provides sour environment, stabilizer can be made to supplement the iodine of loss continuously, maintain the valid density of iodine, reach the most degerming effect.
Above are only the preferred embodiment of the present invention, it is noted that for the ordinary skill technical staff in the industry, can be improved by some and replace under the principle of the present invention, this improvement and replacement also should be regarded as protection scope of the present invention.
Claims (7)
1. the medicated clothing skin degerming agent containing iodine, it is characterised in that its composition is divided into A, B two groups, wherein:
Component A:
Iodine: 0.1-0.3%,
Stabilizer: 0.1-0.3%,
Organic acid: 0.15-0.35%,
Pure water: 20-35%;
B component:
Surfactant: 9-10%,
Organic Alcohol: 60-70%,
Chelating agent: 0.1-0.3%,
Pure water: 23-75%.
2. the method containing iodine medicated clothing skin degerming agent prepared described in claim 1, it is characterised in that:
In pure water, it is sequentially added into elemental iodine, stabilizer, organic acid with continuous stirring, makes uniform component A；In pure water, add surfactant or Organic Alcohol mix homogeneously with continuous stirring, add chelating agent, make even phase B component；Finally B component is added in component A and stir, obtain the bacteria remover solution of golden transparent.
3.
According to described in claim 1 or 2 containing iodine medicated clothing skin degerming agent and preparation method, it is characterised in that described stabilizer is KI, NaI, KIO3、NaIO3In one or more.
4.
According to described in claim 1 or 2 containing iodine medicated clothing skin degerming agent and preparation method, it is characterised in that described organic acid is one or more in formic acid, acetic acid, citric acid, tartaric acid.
5.
According to described in claim 1 or 2 containing iodine medicated clothing skin degerming agent and preparation method, it is characterised in that described surfactant is the nonionic surfactant of fatty alcohol polyethenoxy ether class.
6.
According to described in claim 1 or 2 containing iodine medicated clothing skin degerming agent and preparation method, it is characterised in that described Organic Alcohol is ethanol.
7.
According to described in claim 1 or 2 containing iodine medicated clothing skin degerming agent and preparation method, it is characterised in that described synergism chelating agent is one or more in biguanides, hyperbranched Gemini quaternary ammonium salt amino-compound.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510192722.6A CN106135274A (en) | 2015-04-22 | 2015-04-22 | A kind of medicated clothing skin degerming agent composition containing iodine and preparation method thereof |
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| CN201510192722.6A CN106135274A (en) | 2015-04-22 | 2015-04-22 | A kind of medicated clothing skin degerming agent composition containing iodine and preparation method thereof |
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| CN106135274A true CN106135274A (en) | 2016-11-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632803A (en) * | 2020-04-27 | 2021-11-12 | 瑞普（天津）生物药业有限公司 | Quaternary ammonium salt complex iodine disinfectant and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62185019A (en) * | 1986-02-10 | 1987-08-13 | Ise Kagaku Kogyo Kk | Antiseptic disinfectant for animal and method therefor |
| US5462714A (en) * | 1992-09-22 | 1995-10-31 | Arda Technologies | Antimicrobial composition and methods of use |
| CN1114527A (en) * | 1995-02-17 | 1996-01-10 | 四川省卫生防疫科技开发服务中心 | Complex iodine liquid disinfectant |
| CN1238131A (en) * | 1998-06-09 | 1999-12-15 | 孙文国 | Efficient disinfectant tamed iodine |
| CN102311887A (en) * | 2011-08-18 | 2012-01-11 | 瓮福（集团）有限责任公司 | Iodine-containing antibacterial washing agent and its preparation method |
| CN102550602A (en) * | 2010-11-30 | 2012-07-11 | 中国科学院成都有机化学有限公司 | High-iodine controlled-release type sanitizer |
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2015
- 2015-04-22 CN CN201510192722.6A patent/CN106135274A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62185019A (en) * | 1986-02-10 | 1987-08-13 | Ise Kagaku Kogyo Kk | Antiseptic disinfectant for animal and method therefor |
| US5462714A (en) * | 1992-09-22 | 1995-10-31 | Arda Technologies | Antimicrobial composition and methods of use |
| CN1114527A (en) * | 1995-02-17 | 1996-01-10 | 四川省卫生防疫科技开发服务中心 | Complex iodine liquid disinfectant |
| CN1238131A (en) * | 1998-06-09 | 1999-12-15 | 孙文国 | Efficient disinfectant tamed iodine |
| CN102550602A (en) * | 2010-11-30 | 2012-07-11 | 中国科学院成都有机化学有限公司 | High-iodine controlled-release type sanitizer |
| CN102311887A (en) * | 2011-08-18 | 2012-01-11 | 瓮福（集团）有限责任公司 | Iodine-containing antibacterial washing agent and its preparation method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632803A (en) * | 2020-04-27 | 2021-11-12 | 瑞普（天津）生物药业有限公司 | Quaternary ammonium salt complex iodine disinfectant and preparation method thereof |
| CN113632803B (en) * | 2020-04-27 | 2023-06-20 | 瑞普（天津）生物药业有限公司 | Quaternary ammonium salt complex iodine disinfectant and preparation method thereof |
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Application publication date: 20161123 |