CN106132408B - 一种双环铂的制备方法 - Google Patents

一种双环铂的制备方法 Download PDF

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Publication number
CN106132408B
CN106132408B CN201580002750.5A CN201580002750A CN106132408B CN 106132408 B CN106132408 B CN 106132408B CN 201580002750 A CN201580002750 A CN 201580002750A CN 106132408 B CN106132408 B CN 106132408B
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CN
China
Prior art keywords
carboplatin
bicycloplatin
solvent
solid
blend step
Prior art date
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CN201580002750.5A
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English (en)
Chinese (zh)
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CN106132408A (zh
Inventor
刘晓忠
许继睿
赵晔
张良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hunan Xiangyuan Eastern Medicine Science And Technology Co Ltd
New Nat Products Co
Original Assignee
Hunan Xiangyuan Eastern Medicine Science And Technology Co Ltd
New Nat Products Co
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Publication of CN106132408A publication Critical patent/CN106132408A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201580002750.5A 2015-04-10 2015-04-10 一种双环铂的制备方法 Active CN106132408B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2015/025334 WO2016164040A1 (en) 2015-04-10 2015-04-10 Process for the preparation of dicycloplatin

Publications (2)

Publication Number Publication Date
CN106132408A CN106132408A (zh) 2016-11-16
CN106132408B true CN106132408B (zh) 2018-02-13

Family

ID=56895556

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580002750.5A Active CN106132408B (zh) 2015-04-10 2015-04-10 一种双环铂的制备方法

Country Status (14)

Country Link
US (1) US9447130B1 (https=)
EP (1) EP3280408B1 (https=)
JP (1) JP6925318B2 (https=)
KR (1) KR102432526B1 (https=)
CN (1) CN106132408B (https=)
AU (1) AU2015390714B2 (https=)
CA (1) CA2981158C (https=)
DK (1) DK3280408T3 (https=)
ES (1) ES2765648T3 (https=)
IL (1) IL254894B (https=)
MX (1) MX2017012985A (https=)
RU (1) RU2676269C1 (https=)
WO (1) WO2016164040A1 (https=)
ZA (1) ZA201706795B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017027277A2 (pt) 2015-06-19 2018-09-04 Syn Nat Products Entpr Llc ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula?
BR112017027285A2 (pt) 2015-06-19 2018-09-11 Syn Nat Products Entpr Llc ?cocristal, composição farmacêutica e método para o tratamento de uma doença?
US10428099B2 (en) 2015-06-25 2019-10-01 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
CN106995467B (zh) * 2017-05-03 2019-06-21 江苏大红鹰恒顺药业有限公司 一种微波催化合成双环铂的方法
CN109053808B (zh) * 2017-06-21 2020-12-29 宋勤华 一种高纯度双环铂针状晶体的工业化制备方法
MX2020005310A (es) * 2017-11-21 2020-10-08 Medoncare Pharmaceutical Co Ltd Producto de combinacion que comprende dicicloplatino y metodo de preparacion y uso del mismo.
CN108780053A (zh) * 2018-02-09 2018-11-09 北京索普兴大医药研究有限公司 双环铂药物检测方法
CN108884119A (zh) * 2018-02-22 2018-11-23 昆明贵研药业有限公司 一种双二羧酸二氨络铂(ii)衍生物的制备方法
CN108521780B (zh) * 2018-02-22 2024-08-02 昆明贵研药业有限公司 一锅法制备双二羧酸二氨络铂(ii)衍生物的方法
WO2020056582A1 (zh) * 2018-09-18 2020-03-26 昆明贵研药业有限公司 一种双二羧酸二氨络铂(ii)衍生物的纯化方法
CN112516327B (zh) 2019-08-27 2023-12-15 北京先汉国科生物科技有限公司 卡铂复合物及其药物制剂

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699901B1 (en) * 2000-03-03 2004-03-02 Xuqing Yang Dicarboxylato diammine platinum derivatives and compositions comprising them as anti-tumor agents
US20060216360A1 (en) * 2005-03-28 2006-09-28 Dabur Pharma Ltd. Stable pharmaceutical compositions of platinum (II) antitumour agents
WO2008155727A1 (en) * 2007-06-18 2008-12-24 Platco Technologies (Proprietary) Limited Platinum (iv) complexes
US20090082438A1 (en) * 2005-03-18 2009-03-26 Kazunori Kataoka Coordination Compound Composed of Diaminocyclohexane Platinum (II) and Block Copolymer and Anti-Cancer Agent Comprising the Same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2124251T3 (es) * 1991-03-23 1999-02-01 Sunkyong Ind Ltd Nuevo complejo de platino (ii) y procedimientos para su preparacion.
US5455270A (en) * 1993-08-11 1995-10-03 Bristol-Myers Squibb Co. Stabilized solutions of platinum(II) antitumor agents
ATE431352T1 (de) * 2001-11-30 2009-05-15 Jingzun Wang Supermolekulare carboplatinderivate, deren herstellung und pharmazeutische zusammensetzungen,die diese als wirkstoffe enthalten, sowie anwendungen der zusammensetzungen
US7956208B2 (en) * 2006-01-30 2011-06-07 Platco Technologies (Proprietary) Limited Preparation of platinum (II) complexes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699901B1 (en) * 2000-03-03 2004-03-02 Xuqing Yang Dicarboxylato diammine platinum derivatives and compositions comprising them as anti-tumor agents
US20090082438A1 (en) * 2005-03-18 2009-03-26 Kazunori Kataoka Coordination Compound Composed of Diaminocyclohexane Platinum (II) and Block Copolymer and Anti-Cancer Agent Comprising the Same
US20060216360A1 (en) * 2005-03-28 2006-09-28 Dabur Pharma Ltd. Stable pharmaceutical compositions of platinum (II) antitumour agents
WO2008155727A1 (en) * 2007-06-18 2008-12-24 Platco Technologies (Proprietary) Limited Platinum (iv) complexes

Also Published As

Publication number Publication date
IL254894A0 (en) 2017-12-31
EP3280408B1 (en) 2019-10-23
EP3280408A1 (en) 2018-02-14
RU2676269C1 (ru) 2018-12-27
EP3280408A4 (en) 2018-10-17
AU2015390714B2 (en) 2021-02-04
ES2765648T3 (es) 2020-06-10
IL254894B (en) 2021-02-28
KR20170134737A (ko) 2017-12-06
ZA201706795B (en) 2019-02-27
BR112017021590A2 (pt) 2018-07-03
CN106132408A (zh) 2016-11-16
JP2018510914A (ja) 2018-04-19
AU2015390714A1 (en) 2017-10-26
US9447130B1 (en) 2016-09-20
KR102432526B1 (ko) 2022-08-12
WO2016164040A1 (en) 2016-10-13
CA2981158C (en) 2022-05-24
JP6925318B2 (ja) 2021-08-25
CA2981158A1 (en) 2016-10-13
DK3280408T3 (da) 2020-02-03
MX2017012985A (es) 2018-05-22
US20160297842A1 (en) 2016-10-13

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