CA2981158C - Process for the preparation of dicycloplatin - Google Patents

Process for the preparation of dicycloplatin Download PDF

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Publication number
CA2981158C
CA2981158C CA2981158A CA2981158A CA2981158C CA 2981158 C CA2981158 C CA 2981158C CA 2981158 A CA2981158 A CA 2981158A CA 2981158 A CA2981158 A CA 2981158A CA 2981158 C CA2981158 C CA 2981158C
Authority
CA
Canada
Prior art keywords
carboplatin
dicycloplatin
combining step
solvent
dicarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2981158A
Other languages
English (en)
French (fr)
Other versions
CA2981158A1 (en
Inventor
Xiaozhong Liu
Jirui Xi
Ye Zhao
Liang Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medoncare Pharmaceutical Co Ltd
Syn Nat Products Enterprise LLC
Original Assignee
Xi Jirui
Medoncare Pharmaceutical Co Ltd
Syn Nat Products Enterprise LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xi Jirui, Medoncare Pharmaceutical Co Ltd, Syn Nat Products Enterprise LLC filed Critical Xi Jirui
Publication of CA2981158A1 publication Critical patent/CA2981158A1/en
Application granted granted Critical
Publication of CA2981158C publication Critical patent/CA2981158C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2981158A 2015-04-10 2015-04-10 Process for the preparation of dicycloplatin Active CA2981158C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2015/025334 WO2016164040A1 (en) 2015-04-10 2015-04-10 Process for the preparation of dicycloplatin

Publications (2)

Publication Number Publication Date
CA2981158A1 CA2981158A1 (en) 2016-10-13
CA2981158C true CA2981158C (en) 2022-05-24

Family

ID=56895556

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2981158A Active CA2981158C (en) 2015-04-10 2015-04-10 Process for the preparation of dicycloplatin

Country Status (14)

Country Link
US (1) US9447130B1 (https=)
EP (1) EP3280408B1 (https=)
JP (1) JP6925318B2 (https=)
KR (1) KR102432526B1 (https=)
CN (1) CN106132408B (https=)
AU (1) AU2015390714B2 (https=)
CA (1) CA2981158C (https=)
DK (1) DK3280408T3 (https=)
ES (1) ES2765648T3 (https=)
IL (1) IL254894B (https=)
MX (1) MX2017012985A (https=)
RU (1) RU2676269C1 (https=)
WO (1) WO2016164040A1 (https=)
ZA (1) ZA201706795B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017027277A2 (pt) 2015-06-19 2018-09-04 Syn Nat Products Entpr Llc ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula?
BR112017027285A2 (pt) 2015-06-19 2018-09-11 Syn Nat Products Entpr Llc ?cocristal, composição farmacêutica e método para o tratamento de uma doença?
US10428099B2 (en) 2015-06-25 2019-10-01 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
CN106995467B (zh) * 2017-05-03 2019-06-21 江苏大红鹰恒顺药业有限公司 一种微波催化合成双环铂的方法
CN109053808B (zh) * 2017-06-21 2020-12-29 宋勤华 一种高纯度双环铂针状晶体的工业化制备方法
MX2020005310A (es) * 2017-11-21 2020-10-08 Medoncare Pharmaceutical Co Ltd Producto de combinacion que comprende dicicloplatino y metodo de preparacion y uso del mismo.
CN108780053A (zh) * 2018-02-09 2018-11-09 北京索普兴大医药研究有限公司 双环铂药物检测方法
CN108884119A (zh) * 2018-02-22 2018-11-23 昆明贵研药业有限公司 一种双二羧酸二氨络铂(ii)衍生物的制备方法
CN108521780B (zh) * 2018-02-22 2024-08-02 昆明贵研药业有限公司 一锅法制备双二羧酸二氨络铂(ii)衍生物的方法
WO2020056582A1 (zh) * 2018-09-18 2020-03-26 昆明贵研药业有限公司 一种双二羧酸二氨络铂(ii)衍生物的纯化方法
CN112516327B (zh) 2019-08-27 2023-12-15 北京先汉国科生物科技有限公司 卡铂复合物及其药物制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2124251T3 (es) * 1991-03-23 1999-02-01 Sunkyong Ind Ltd Nuevo complejo de platino (ii) y procedimientos para su preparacion.
US5455270A (en) * 1993-08-11 1995-10-03 Bristol-Myers Squibb Co. Stabilized solutions of platinum(II) antitumor agents
CN1121380C (zh) * 2000-03-03 2003-09-17 北京兴大豪斯科技有限公司 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物
ATE431352T1 (de) * 2001-11-30 2009-05-15 Jingzun Wang Supermolekulare carboplatinderivate, deren herstellung und pharmazeutische zusammensetzungen,die diese als wirkstoffe enthalten, sowie anwendungen der zusammensetzungen
WO2006098496A1 (ja) * 2005-03-18 2006-09-21 The University Of Tokyo ジアミノシクロヘキサン白金(ii)とブロック共重合体との配位化合物及びそれを含有する抗がん剤
AU2005329764B2 (en) * 2005-03-28 2010-08-12 Dabur Pharma Ltd. Stable pharmaceutical compositions of platinum (II) antitumour agents
US7956208B2 (en) * 2006-01-30 2011-06-07 Platco Technologies (Proprietary) Limited Preparation of platinum (II) complexes
WO2008155727A1 (en) * 2007-06-18 2008-12-24 Platco Technologies (Proprietary) Limited Platinum (iv) complexes

Also Published As

Publication number Publication date
IL254894A0 (en) 2017-12-31
EP3280408B1 (en) 2019-10-23
EP3280408A1 (en) 2018-02-14
CN106132408B (zh) 2018-02-13
RU2676269C1 (ru) 2018-12-27
EP3280408A4 (en) 2018-10-17
AU2015390714B2 (en) 2021-02-04
ES2765648T3 (es) 2020-06-10
IL254894B (en) 2021-02-28
KR20170134737A (ko) 2017-12-06
ZA201706795B (en) 2019-02-27
BR112017021590A2 (pt) 2018-07-03
CN106132408A (zh) 2016-11-16
JP2018510914A (ja) 2018-04-19
AU2015390714A1 (en) 2017-10-26
US9447130B1 (en) 2016-09-20
KR102432526B1 (ko) 2022-08-12
WO2016164040A1 (en) 2016-10-13
JP6925318B2 (ja) 2021-08-25
CA2981158A1 (en) 2016-10-13
DK3280408T3 (da) 2020-02-03
MX2017012985A (es) 2018-05-22
US20160297842A1 (en) 2016-10-13

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