CN106110210A - A kind of Chinese medicine treating gastric ulcer and preparation method thereof - Google Patents

Abstract

nullThe present invention relates to a kind of Chinese medicine treating gastric ulcer and preparation method thereof，This Chinese medicine is made up of the crude drug of following weight portion: Rhizoma Coptidis 170～190 parts、Fructus Hedychii Spicati 170～190 parts、Folium Fortunellae Margarita 170～190 parts、Fructus Hippophae 140～160 parts、Rhizoma Curcumae Longae 140～160 parts、Rhizoma Smilacis Glabrae 110～130 parts、Bark of Lindenleaf Torricellia 110～130 parts、Radix viticis negundo 80～100 parts、Radix Ampelopsis delavayanae 80～100 parts、Thin Caulis Piperis Boehmeriaefolii 50～70 parts、Herba Patriniae 50～70 parts、Radix Cypripedii Henryi 80～100 parts、Radix Vladimiriae 80～100 parts、Folium Styracis Suberifoliae 70～90 parts、Herba Serissae 70～90 parts、Radix Aristolochiae 50～70 parts、Juncus amplifolius A. Camus 50～70 parts、Endoconcha Sepiae 50～70 parts、Rhizoma Kaempferiae 70～90 parts、Concha Arcae 50～70 parts、Sarcococca ruscifolia Stapf 30～50 parts、Folium Ilicis Pubescentis 30～50 parts、Radix Zanthoxyli Spinifolii 20～40 parts、Herba galinsogae parviflorae 20～40 parts、Folium Trachycarpi 20～40 parts；Chinese medicine of the present invention has heat clearing and damp drying, promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, astringing to arrest bleeding, antacid, detoxicating, relieving inflammation effect.

Description

A kind of Chinese medicine treating gastric ulcer and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine treating gastric ulcer and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Gastric ulcer is clinical commonly encountered diseases and frequently-occurring disease, and its sickness rate ratio shared by crowd is the highest, gastric ulcer Patient the most then feels sick, belch, the decline of heavy then appetite, and malnutrition is had blood in stool, and brings the biggest misery to patient, therefore, for The treatment of gastric ulcer meaning clinically is the most great.

Gastric ulcer refers to the ulcer that gastric mucosa is caused by gastric acid/pepsin autodigestion under certain conditions, and it is deep Degree has met or exceeded muscular layer of mucosa.It is long that primary disease has the course of disease, easily the feature of recurrence, and easily occur hemorrhage, bore a hole, block etc. also Sending out disease, the incidence rate of malignant change of benign gastric ulcer is about 1%～2%.Modern medicine thinks that gastric ulcer is due to for gastric mucosa Invasion and attack factor and defending factors disequilibrium caused by.Invasion and attack factor mainly have helicobacter pylori (Hp), gastric acid, pepsin, Nonsteroidal antiinflammatory drug etc..Defending factors mainly includes that gastric mucus-mucosal barrier, mucomembranous cell update and be good for ability, mucosa again Blood flow and multiple gut hormone effect etc..Wherein Hp infection, gastric acid and gastric mucosal defense reduced capability are to cause gastric ulcer to occur Main cause.The medicine of clinical treatment gastric ulcer includes gastric acid secretion inhibiting medicine, neutralizes gastric acid medicine, cholinolytic at present Energy medicine, eradicating Hp medicine and protection gastric mucosa medicine etc..But long-term takes this kind of Western medicine, produces gastrointestinal tract bad Reaction occurs so that the compliance of patient is poor.And after these medicine drug withdrawals, ulcer recurrence rate is the highest.In traditional Medicine has preferable curative effect in the clinical symptoms improving Peptic Ulcers patient, and has that relapse rate is low, compliance good, side effect Little advantage.

Gastric ulcer Chinese medicine " gastric abscess ", category, just to cold-evil, the poison cause gastral cavilty such as heresy, seven emotions, diet in "Nei Jing" The etiology and pathogenesis of pain has carried out detailed discussion, " Plain Questions lift pain opinion " cloud: " cold-evil visitor between the intestines and stomach, under film is former.Blood is not Must dissipate, contraction of small collaterals resulting in pain, the then vim and vigour pressed dissipate, therefore the pain pressed is only " cold heat and summer-heat moisture heresy injures one's stomach, and obstruction mechanism of qi, blood stuffiness is not OK, or counter rise etc. of turbid QI failing to descend causes gastralgia.Primary disease or because food stagnation, insufficiency of the spleen, blood stasis, phlegm retention, taste worm are evil, hot and suffocating, the stagnation of QI Etc. paathogenic factor.The most how to be hindered by exopathogen, diet, feelings will, for excess pathogen；After mostly be spleen, the healthy energy such as suffer from a deficiency of the kidney is deficient and causes controlling for a long time Do not heal, ferritic weakness of the spleen and stomach, transformation failure of spleen, functional activity of QI being not smooth, or insufficiency of spleen-YANG, deficiency-cold in middle-JIAO, loses its replenishing vital QI with drugs of warm nature and pain of aching.It is sick Machine it is critical only that gastric qi retardance, stomach-QI being unable to descend normally, stagnation of QI and blood may bring about pain.Its sick position is at stomach, in close relations with liver spleen kidney, the key of pathogenesis It is middle burnt functional activity of QI being not smooth, taste abnormal ascending-descending of QI.Differentiation of symptoms and signs for classification of syndrome is divided into hot and suffocating in stomach, QI stagnated by cold, eating accumulation, stagnation of liver-QI gas more Seven types such as stagnant, congestion resistance network, Deficiency and coldness of spleen and stomach, deficiency of stomach-Yin.Chinese medicine gastric ulcer is many from weakness of the spleen and stomach, damp-heat in the spleen and stomach, liver Gas is violated the pattern of syndrome aspect such as stomach, congestion resistance network and is carried out Coryza Treated by Syndrome Differentiation.This type of disease can be played the work for the treatment of both the principal and secondary aspects of a disease by Chinese medicine With, there is good effect, side effect is little, cheap advantage.

Summary of the invention

In order to solve the problems referred to above, the invention provides a kind of Chinese medicine treating gastric ulcer and preparation method thereof, the present invention Chinese medicine there is treatment gastric ulcer determined curative effect, have no adverse reaction and the feature such as relapse rate is low.

Traditional Chinese medicine technology scheme of the present invention is as follows:

The present invention treats the Chinese medicine of gastric ulcer, and it is made up of the crude drug of following weight portion: Rhizoma Coptidis, Fructus Hedychii Spicati, Fructus Fortunellae Margaritae Leaf, Fructus Hippophae, Rhizoma Curcumae Longae, Rhizoma Smilacis Glabrae, Bark of Lindenleaf Torricellia, Radix viticis negundo, Radix Ampelopsis delavayanae, thin Caulis Piperis Boehmeriaefolii, Herba Patriniae, Radix Cypripedii Henryi, Radix Vladimiriae, Folium Styracis Suberifoliae, Herba Serissae, Radix Aristolochiae, Juncus amplifolius A. Camus, Endoconcha Sepiae, Rhizoma Kaempferiae, Concha Arcae, Sarcococca ruscifolia Stapf, Folium Ilicis Pubescentis, Radix Zanthoxyli Spinifolii, Herba galinsogae parviflorae, Folium Trachycarpi.

Fang Zhongxuan with Rhizoma Coptidis, Fructus Hedychii Spicati, Folium Fortunellae Margarita, three medicine mutual reinforcement between compatibilities altogether as monarch drug, can heat clearing and damp drying；Minister is anticipated with Fructus Hippophae At solid protection QI of the spleen and stomach, in case the property imapirment of the spleen and stomach of Rhizoma Coptidis bitter cold.Rhizoma Curcumae Longae can removing blood stasis circulation of qi promoting, Rhizoma Smilacis Glabrae removing toxic substances, Radix viticis negundo, can regulate the flow of vital energy Pain relieving, joins again Radix Ampelopsis delavayanae, thin Caulis Piperis Boehmeriaefolii, strengthens the merit of blood circulation promoting and blood stasis dispelling, selects with Herba Patriniae heat-clearing and toxic substances removing, helps with Radix Cypripedii Henryi, river wood Perfume, Folium Styracis Suberifoliae, Sarcococca ruscifolia Stapf, Radix Zanthoxyli Spinifolii, promoting the circulation of QI to relieve pain, Herba Serissae heat-clearing and toxic substances removing, Radix Aristolochiae circulation of qi promoting stomach invigorating, Juncus amplifolius A. Camus regulating QI to relieve pain, It is aided with Bark of Lindenleaf Torricellia, Endoconcha Sepiae, Concha Arcae, Folium Trachycarpi four taste, the merit of can hold concurrently astringing to arrest bleeding, antacid again；Rhizoma Kaempferiae circulation of qi promoting warming middle-JIAO, Mao Dong Folium Isatidis blood circulation and channel invigorating, Herba galinsogae parviflorae can antiinflammatory, the same use of all medicines, complement each other, on the whole health be adjusted, to reach mediation spleen Stomach, thus play heat clearing and damp drying, promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, astringing to arrest bleeding, antacid, the merit of detoxicating, relieving inflammation, to reach to treat stomach The purpose of ulcer.

The consumption of the Chinese medicine of the present invention also draws through substantial amounts of clinical empirical summary, and each amounts of components is following Weight portion scope all has a preferable curative effect:

Chinese medicine of the present invention, it is made up of the crude drug of following weight portion: Rhizoma Coptidis 170～190 parts, Fructus Hedychii Spicati 170～190 Part, Folium Fortunellae Margarita 170～190 parts, Fructus Hippophae 140～160 parts, Rhizoma Curcumae Longae 140～160 parts, Rhizoma Smilacis Glabrae 110～130 parts, Bark of Lindenleaf Torricellia 110 ～130 parts, Radix viticis negundo 80～100 parts, Radix Ampelopsis delavayanae 80～100 parts, thin Caulis Piperis Boehmeriaefolii 50～70 parts, Herba Patriniae 50～70 parts, dragon tongue Arrow 80～100 parts, Radix Vladimiriae 80～100 parts, Folium Styracis Suberifoliae 70～90 parts, Herba Serissae 70～90 parts, Radix Aristolochiae 50～70 parts, Juncus amplifolius A. Camus 50～70 parts, Endoconcha Sepiae 50～70 parts, Rhizoma Kaempferiae 70～90 parts, Concha Arcae 50～70 parts, Sarcococca ruscifolia Stapf 30～50 parts, Folium Ilicis Pubescentis 30 ～50 parts, Radix Zanthoxyli Spinifolii 20～40 parts, Herba galinsogae parviflorae 20～40 parts, Folium Trachycarpi 20～40 parts.

Preferred as Chinese medicine of the present invention, it is made up of the crude drug of following weight portion: Rhizoma Coptidis 180 parts, Fructus Hedychii Spicati 180 Part, Folium Fortunellae Margarita 180 parts, Fructus Hippophae 150 parts, 150 parts of Rhizoma Curcumae Longae, Rhizoma Smilacis Glabrae 120 parts, Bark of Lindenleaf Torricellia 120 parts, Radix viticis negundo 90 parts, Radix Ampelopsis delavayanae 90 parts, thin Caulis Piperis Boehmeriaefolii 60 parts, Herba Patriniae 60 parts, Radix Cypripedii Henryi 90 parts, Radix Vladimiriae 90 parts, Folium Styracis Suberifoliae 80 parts, Herba Serissae 80 parts, Radix Aristolochiae 60 parts, Juncus amplifolius A. Camus 60 parts, Endoconcha Sepiae 60 parts, Rhizoma Kaempferiae 80 parts, Concha Arcae 60 parts, Sarcococca ruscifolia Stapf 40 parts, Folium Ilicis Pubescentis 40 parts, Radix Zanthoxyli Spinifolii 30 parts, Herba galinsogae parviflorae 30 parts, Folium Trachycarpi 30 parts.

The active component of the Chinese medicine of the present invention can add the adjuvant preparing the various routines needed for different dosage form, such as disintegrate Agent, lubricant, filler, binding agent etc. are prepared as any conventional peroral dosage form with conventional prescription method, such as capsule Agent, granule, tablet, drop pill etc..

Described Chinese medicine is preferably capsule.

The preparation method of Chinese medicine of the present invention, it is made up of the steps:

(1), take Rhizoma Curcumae Longae, Endoconcha Sepiae, Concha Arcae, be ground into fine powder；

(2), take again Rhizoma Coptidis, Fructus Hedychii Spicati, Folium Fortunellae Margarita, Fructus Hippophae, Rhizoma Smilacis Glabrae, Bark of Lindenleaf Torricellia, Radix viticis negundo, Radix Ampelopsis delavayanae, thin Caulis Piperis Boehmeriaefolii, Herba Patriniae, Radix Cypripedii Henryi, Radix Vladimiriae, Folium Styracis Suberifoliae, Herba Serissae, Radix Aristolochiae, Juncus amplifolius A. Camus, Rhizoma Kaempferiae, Sarcococca ruscifolia Stapf, Folium Ilicis Pubescentis, Radix Zanthoxyli Spinifolii, peppery Son grass, Folium Trachycarpi merge, and add and the soak by water that medical material weight ratio is 7～12 times amount 2 times, each 1～2h, filter, merging filtrate, Filtrate is performing centrifugal separation on processing, and centrifugal rotational speed is 3000～5000r/min, and filtrate is reduced pressure dense by centrifugation time 20～40min Shortening relative density into is 1.30～1.40 thick pastes, adds above-mentioned steps fine powder (1), after mix homogeneously, in reduced vacuum 60～70 DEG C being dried to dry extract, and pulverize and sieve, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add on pharmaceutics Various different oral formulations made by conventional adjuvant, to obtain final product.

Preferably, the preparation method of Chinese medicine of the present invention, it is made up of the steps:

(1), take Rhizoma Curcumae Longae, Endoconcha Sepiae, Concha Arcae, be ground into 120 (mesh) fine powder；

(2), take again Rhizoma Coptidis, Fructus Hedychii Spicati, Folium Fortunellae Margarita, Fructus Hippophae, Rhizoma Smilacis Glabrae, Bark of Lindenleaf Torricellia, Radix viticis negundo, Radix Ampelopsis delavayanae, thin Caulis Piperis Boehmeriaefolii, Herba Patriniae, Radix Cypripedii Henryi, Radix Vladimiriae, Folium Styracis Suberifoliae, Herba Serissae, Radix Aristolochiae, Juncus amplifolius A. Camus, Rhizoma Kaempferiae, Sarcococca ruscifolia Stapf, Folium Ilicis Pubescentis, Radix Zanthoxyli Spinifolii, peppery Son grass, Folium Trachycarpi merge, and add and the soak by water that medical material weight ratio is 10 times amount 2 times, each 1.5h, filter, merging filtrate, filtrate Being performing centrifugal separation on processing, centrifugal rotational speed is 4000r/min, centrifugation time 30min, and filtrate concentrating under reduced pressure becomes relative density be 1.30～1.40 thick pastes, add above-mentioned steps fine powder (1), after mix homogeneously, are dried to dry extract in reduced vacuum 65 DEG C, and Pulverizing and sieving, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add on pharmaceutics Various different oral formulations made by conventional adjuvant, to obtain final product.

In side, the source of each medicine, nature and flavor, and effect are as follows:

Rhizoma Coptidis, for ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch. Coptis deltoidea C.Y.Cheng et Hsiao Coptis Deltoidea C.Y.Chenget Hsiao or the dry rhizome of Coptis Teeta Wall Coptis teeta Wall..Nature and flavor, bitter, cold.Merit Effect, heat clearing and damp drying, eliminating fire and detoxication.

Fructus Hedychii Spicati, for the fruit of zingiberaceous plant Hedychium spicatum Ham.Ex Smith Fructus Hedychii Spicati.Nature and flavor, taste Pungent, micro-hardship, warm in nature.Effect, warming spleen and stomach for dispelling cold, regulate the flow of vital energy and help digestion.

Folium Fortunellae Margarita, for Rutaceae plant Fructus Fortunellae Margaritae and the leaf of gold bullet.Nature and flavor, pungent, bitter, cold nature is nontoxic.Effect, soothing liver-QI solution Strongly fragrant, eliminating stagnation of regulating the flow of vital energy.

Fructus Hippophae, for the dry mature fruit of Elaeangnaceae hippophae plant Fructus Hippophae Hippophae rhamnoides L..Property Taste, sour, puckery, temperature.Effect, eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.

Rhizoma Curcumae Longae, for the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae Curcuma longa L..Nature and flavor, pungent, bitter, temperature.Effect, removing blood stasis Circulation of qi promoting, inducing menstruation to relieve menalgia.

Rhizoma Smilacis Glabrae, for the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..Nature and flavor, sweet, light, Flat.Effect, dehumidifying, removing toxic substances, easing joint movement.

Bark of Lindenleaf Torricellia, for Sterculiaceae Bark of Lindenleaf Torricellia Eriolaena malvacea (Levl.) Hand.-Mazz., enters with root endothelium Medicine.Nature and flavor, bitter, puckery, cool.Effect, astringing to arrest bleeding, reuniting the fractured tendons and bones.

Radix viticis negundo, for the root of Verbenaceae Vitex negundo L five-leaved chaste tree.Nature and flavor, acrid in the mouth；Micro-hardship；Warm in nature.Merit Effect, induces sweat；Cough-relieving；Expelling wind and removing dampness；Regulating QI to relieve pain.

Radix Ampelopsis delavayanae, for vitaceae Ampelopsis delavayana (Franch.) Planch. [Vitis The root of delavayana Franch. trilobated leaf Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) or root bark.Effect, clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, hemostasia and promoting granulation, removing toxic substances Detumescence.

Thin Caulis Piperis Boehmeriaefolii, for the Herb that Piperaceae plant PipermullesuaD.Don is short.Nature and flavor, pungent；Temperature.Effect, dispels Wind, dissipating cold；Eliminating stasis to stop pain；Subduing swelling and detoxicating.

Herba Patriniae, for Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud Patrinia scabiosaefolia Fisch.ex Link., Patrima villosa P.villosa (Thunb.) Juss., with root stock and root, all herbal medicine.Nature and flavor, pungent, bitter, cool.Effect, heat clearing away Removing toxic substances, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.

Radix Cypripedii Henryi, the orchid family Radix Cypripedii Henryi Cypripedium henryi Rolfe, is used as medicine with root.Nature and flavor, bitter, temperature.Effect, reason Gas promoting the circulation of blood, reducing swelling and alleviating pain.

Radix Vladimiriae, for feverfew Radix Vladimiriae Vladimiria souliei (Franch.) Ling or gray wool Radix Vladimiriae The dry root of Vladimiria souliei (Franch.) Ling var.cinerea Ling.Nature and flavor, pungent, bitter, temperature.Effect, Promoting the circulation of QI to relieve pain.

Herba Serissae, for Compositae feverwort Herba Serissae Eupatorium chinense L., is used as medicine with root.Nature and flavor, micro- Hardship, cool.Effect, heat-clearing and toxic substances removing, sore-throat relieving reduces phlegm.

Folium Styracis Suberifoliae, Styracaceae Folium Styracis Suberifoliae Styrax suberifolium Hook.et Arn., is used as medicine with leaf, root.Nature and flavor, Pungent, tepor.Effect, expelling wind and removing dampness, regulating QI to relieve pain.

Radix Aristolochiae, for the root of aristolochiaceae plant Radix Aristolochiae.Nature and flavor, bitter, tepor.Effect, circulation of qi promoting stomach invigorating, pain relieving.

Juncus amplifolius A. Camus, for rush family Juncus amplifolius A. Camus Juncus amplifolius Camus, is used as medicine with root.Nature and flavor, pungent, bitter, Flat.Effect, regulating QI to relieve pain, regulating menstruation and activating blood.

Endoconcha Sepiae, for Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindroni de Rochebrune or golden cuttlefish The dry inner shell of Sepia esculenta Hoyle.Nature and flavor, salty, puckery, temperature.Effect, astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, hold back Skin ulcer.

Rhizoma Kaempferiae, for the dry rhizome of zingiberaceous plant Rhizoma Kaempferiae Kaempferia galanga L..Nature and flavor, pungent, temperature.Effect, OK In temperature, help digestion, pain relieving.

Concha Arcae, for Carnis Arca inflata section animal Scapharca subcrenata Arca subcrenata Lischke, Tegillarca granosa Arca granosa Linnaeus or the shell of Scapharca broughtonii Arca inflata Reeve.Nature and flavor, salty, flat.Effect, expectorant blood stasis dispelling, hard masses softening and resolving, antacid Pain relieving.

Sarcococca ruscifolia Stapf, for Buxaceae Sarcococca plant fragrance osmanthus Sarcococca ruscifolia Stapf, enters with root Medicine.Nature and flavor, pungent, bitter, flat.Effect, root: regulating QI to relieve pain, dispelling, collateral-activating.

Folium Ilicis Pubescentis, for Aquifoliaceae Holly Radix Ilicis Pubescentis Ilex pubescens Hook.et Arn., with root and leaf It is used as medicine.Nature and flavor, bitter, flat.Effect, blood circulation and channel invigorating, reducing swelling and alleviating pain, heat-clearing and toxic substances removing.

Radix Zanthoxyli Spinifolii, for Rutaceae xanthoxylum Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils Zanthoxylum dimorphophyllum Hemsl.var.spinifolium Rehd.et Wils., is used as medicine with root bark.Effect, regulating QI to relieve pain.

Herba galinsogae parviflorae, for Compositae Herba galinsogae parviflorae Galinsoga parviflora Cav., with all herbal medicine.Nature and flavor, light, flat.Merit Effect, hemostasis, antiinflammatory.

Folium Trachycarpi, for the leaf of babassu Trachycarpusfortunei (Hook.) H.Wendl Petiolus Trachycarpi.Nature and flavor, taste Hardship, puckery, property is put down.Effect, astringing to arrest bleeding.

The mensuration of 1 Chinese medicine content composition of the present invention

The Chinese medicine prepared according to the embodiment of the present invention 1 preparation method, according to " total flavones " and " total polysaccharides " index determining side Method measures the content of total flavones, total polysaccharides respectively.

Table 1 Chinese medicine of the present invention assay

The beneficial effect of Chinese medicine of the present invention:

Each crude drug component in Chinese medicine of the present invention and proportioning thereof, be to combine sending out of the application under guidance of traditional Chinese medicine theory A person of good sense gropes out through clinical empirical summary for many years.Its each medical material compatibility so that full side produces the effect of Synergistic. All medicines share, and play heat clearing and damp drying, promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, astringing to arrest bleeding, antacid altogether, effect of detoxicating, relieving inflammation.This Chinese medicine pin Links structure adjusting to gastric ulcer, can play the target for the treatment of both the principal and secondary aspects of a disease, thus effectively prevent disease palindromia.

Chinese medicine of the present invention is evident in efficacy to the treatment of gastric ulcer, to duodenal ulcer, chronic gastritis and other reason institute Cause stomach discomfort, there is certain curative effect.Chinese prescription of the present invention is reasonable, and preparation technology science is feasible.According to optimization of the present invention Preparation method, the total flavones in active ingredient of Chinese herbs can be obtained and total polysaccharides efficiency index content is significantly improved.Pharmacology Test result indicate that, Chinese medicine of the present invention has antiulcer, gastric acid inhibitory, gastric secretion and pepsin activity and analgesic activity, This also illustrates, Chinese medicine of the present invention has good therapeutical effect to gastric ulcer.

Verifying through clinical trial, the overall clinical efficacy rate of the present invention is 91.4%, and clinical effective rate is better than matched group (stomach Capsule must be pacified).The relapse rate of Chinese medicine of the present invention is only 1.23%.Chinese medicine of the present invention has evident in efficacy, has no adverse reaction, recurrence The advantage that rate is low.In sum, this further shows that, Chinese medicine of the present invention has wide market prospect, is worth clinically Promotion and application.

The beneficial effect of of the present invention Chinese medicine is expanded on further below by way of test example, these test examples include the present invention The pharmacology test of Chinese medicine and clinical observation on the therapeutic effect test.

1. pharmacology test: the experimentation to gastric ulcer of Chinese medicine of the present invention

1.1 test materials and result processing method:

1.1.1 medicine and reagent: WEIDE peace capsule (Meifeng Pharmaceutical Factory Fuzhou City of Jinting Pharmaceutical Co., Ltd.)；Ah Si Woods: (Henan Fusen Medicine Co., Ltd).

The preparation of 1.2 trial drugs:

The preparation of trial drug the most of the present invention:

(1), take Rhizoma Curcumae Longae 150g, Endoconcha Sepiae 60g, Concha Arcae 60g, be ground into 120 (mesh) fine powder；

(2), take again Rhizoma Coptidis 180g, Fructus Hedychii Spicati 180g, Folium Fortunellae Margarita 180g, Fructus Hippophae 150g, Rhizoma Smilacis Glabrae 120g, Bark of Lindenleaf Torricellia 120g, Radix viticis negundo 90g, Radix Ampelopsis delavayanae 90g, thin Caulis Piperis Boehmeriaefolii 60g, Herba Patriniae 60g, Radix Cypripedii Henryi 90g, Radix Vladimiriae 90g, Folium Styracis Suberifoliae 80g, Herba Serissae 80g, Radix Aristolochiae 60g, Juncus amplifolius A. Camus 60g, Rhizoma Kaempferiae 80g, Sarcococca ruscifolia Stapf 40g, Folium Ilicis Pubescentis 40g, Radix Zanthoxyli Spinifolii 30g, Herba galinsogae parviflorae 30g, palm fibre Palmitic acid leaf 30g, adds and the soak by water that medical material weight ratio is 10 times amount 2 times, each 1.5h, filters, and merging filtrate, filtrate is divided by centrifugation From process, centrifugal rotational speed is 4000r/min, centrifugation time 30min, filtrate concentrating under reduced pressure is become relative density be 1.30～ 1.40 thick pastes, add above-mentioned steps fine powder (1), after mix homogeneously, are dried to dry extract in reduced vacuum 65 DEG C, and pulverized Sieve, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs.Before use, distilled water is added It is configured to test required concentration.

1.3 animal Kunming mouses, are provided by Shaanxi university of TCM doctor's Experimental Animal Center.

2 test methods and result:

2.1 impacts on mice stress gastric ulcer

Choose healthy Kunming mouse 45, male and female half and half, be randomly divided into 3 groups, respectively model group, WEIDE peace capsule, Chinese drug-treated group of the present invention, each 10 groups.Every day gastric infusion 1 time, continuous 6 days.Last be administered after l hour, mice fasting 24 hours After, extremity are fixed in template, are soaked in 12 hours (overnight) in 21～26 DEG C of water.Take out animal, put to death, dissect and tie respectively Prick stomach pylorus and cardia, and gastric only injects 3% formalin 1ml/.After fixing 10 minutes, dissect bursting of Microscopic observation stomach Infections is counted.Result of the test is shown in Table 2.

Mice stomach Area of ulcer is compared (x ± s) by table 2

Experimental result from table 2: compared with model control group, Chinese drug-treated group of the present invention and the WEIDE peace equal energy of Capsules group Enough significantly reduce the Area of ulcer of mice stress gastric ulcer, and Chinese drug-treated group of the present invention is excellent to the curative effect of mice stress gastric ulcer Capsules group is pacified in WEIDE.

2.2 on Mouse Stomach liquid measure, total acidity gastric juice, the impact of pepsin activity

Choose healthy Kunming mouse 45, male and female half and half.It is randomly divided into 3 groups, for model control group, WEIDE peace capsule Group, Chinese drug-treated group of the present invention, every day, ig was administered once, continuous 6 days.Last be administered after l hour, mice fasting 24 hours.Each test group Animal under pentobarbital sodium (50mg/kg, ip) is anaesthetized, skin of sterilizing, cut open the belly, ligature stomach pylorus, each group 12 finger respectively 1 (the same given low of dosage) skin suture afterwards of enteral administration.Post operation 3 hours, then open abdomen extraction gastric juice, measure volume (ml), And convert the ml number for every 20g body weight.Take gastric juice titrimetry (titrating, using phenolphthalein as indicator) with 0.01NNaOH to measure Gastric acidity, measures pepsin activity with Mai Teshi capillary glass-tube method.Result of the test is shown in Table 3.

Table 3 is to Mouse Stomach liquid measure, total acidity gastric juice, the mensuration (n=15, x ± s) of pepsin activity

Result of the test 3 shows, Chinese medicine of the present invention and WEIDE peace capsule all can reduce Mouse Stomach liquid measure, total acidity gastric juice, Pepsin activity, effect is better than WEIDE peace Capsules group, and this also illustrates, Chinese medicine of the present invention has certain treatment and makees gastric ulcer With.

2.3 analgesic activity

Take Kunming mouse 45, male and female half and half, be randomly divided into 3 groups, be i.e. model group, aspirin group, Chinese medicine of the present invention Group, often group 10.Gastric infusion volume is 0.5ml/10g, and model control group gives equal-volume distilled water.Gastric infusion continuously 7 days, last was administered latter 1 hour, and each Mus lumbar injection 0.6% acetum 0.2ml/ only, and after 5 minutes, counts 10 minutes The writhing response number of times that interior each Mus occurs.Result of the test is shown in Table 4.

The comparison (x ± s) of mouse writhing reaction times respectively organized by table 4

Result of the test 4 shows, compared with model control group, Chinese medicine of the present invention can substantially reduce the mice that acetic acid causes Writhing number of times.

Detailed description of the invention

The following is the specific embodiment of the present invention, technical scheme is done to be described further, but the present invention Protection domain be not limited to these embodiments.Every change without departing substantially from present inventive concept or equivalent replacement are included in this Within bright protection domain.

Prepared by the capsule of embodiment 1 Chinese medicine of the present invention

(1), take Rhizoma Curcumae Longae 150g, Endoconcha Sepiae 60g, Concha Arcae 60g, be ground into 120 (mesh) fine powder；

(2), take again Rhizoma Coptidis 180g, Fructus Hedychii Spicati 180g, Folium Fortunellae Margarita 180g, Fructus Hippophae 150g, Rhizoma Smilacis Glabrae 120g, Bark of Lindenleaf Torricellia 120g, Radix viticis negundo 90g, Radix Ampelopsis delavayanae 90g, thin Caulis Piperis Boehmeriaefolii 60g, Herba Patriniae 60g, Radix Cypripedii Henryi 90g, Radix Vladimiriae 90g, Folium Styracis Suberifoliae 80g, Herba Serissae 80g, Radix Aristolochiae 60g, Juncus amplifolius A. Camus 60g, Rhizoma Kaempferiae 80g, Sarcococca ruscifolia Stapf 40g, Folium Ilicis Pubescentis 40g, Radix Zanthoxyli Spinifolii 30g, Herba galinsogae parviflorae 30g, palm fibre Palmitic acid leaf 30g, adds and the soak by water that medical material weight ratio is 10 times amount 2 times, each 1.5h, filters, and merging filtrate, filtrate is divided by centrifugation From process, centrifugal rotational speed is 4000r/min, centrifugation time 30min, filtrate concentrating under reduced pressure is become relative density be 1.30～ 1.40 thick pastes, add above-mentioned steps fine powder (1), after mix homogeneously, are dried to dry extract in reduced vacuum 65 DEG C, and pulverized Sieve, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add magnesium stearate After mix homogeneously, fill and make 1000 hard capsules and get final product.

Prepared by the granule of embodiment 2 Chinese medicine of the present invention

(1), take Rhizoma Curcumae Longae 160g, Endoconcha Sepiae 50g, Concha Arcae 70g, be ground into 120 (mesh) fine powder；

(2), take again Rhizoma Coptidis 170, Fructus Hedychii Spicati 190g, Folium Fortunellae Margarita 170g, Fructus Hippophae 160 parts, Rhizoma Smilacis Glabrae 110g, Bark of Lindenleaf Torricellia 110g, Radix viticis negundo 80g, Radix Ampelopsis delavayanae 100g, thin Caulis Piperis Boehmeriaefolii 70g, Herba Patriniae 50g, Radix Cypripedii Henryi 100g, Radix Vladimiriae 100g, Folium Styracis Suberifoliae 70g, Hua Ze Blue 90g, Radix Aristolochiae 50g, Juncus amplifolius A. Camus 70g, Rhizoma Kaempferiae 70g, Sarcococca ruscifolia Stapf 30g, Folium Ilicis Pubescentis 50g, Radix Zanthoxyli Spinifolii 20g, Herba galinsogae parviflorae 40g, Folium Trachycarpi 20g merges, and adds and the soak by water that medical material weight ratio is 7 times amount 2 times, each 1h, filters, merging filtrate, filtrate through from Heart separating treatment, centrifugal rotational speed is 3000/min, centrifugation time 40min, and it is 1.30 that filtrate concentrating under reduced pressure becomes relative density ～1.40 thick pastes, add above-mentioned steps fine powder (1), after mix homogeneously, be dried to dry extract in reduced vacuum 60 DEG C, and pulverize Sieving, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add lactose, dextrin Make 1000g granule, to obtain final product.

Prepared by the tablet of embodiment 3 Chinese medicine of the present invention

(1), take Rhizoma Curcumae Longae 140g, Endoconcha Sepiae 70g, Concha Arcae 50g, be ground into 120 (mesh) fine powder；

(2), take Rhizoma Coptidis 190g, Fructus Hedychii Spicati 170g, Folium Fortunellae Margarita 190g, Fructus Hippophae 140 parts, Rhizoma Smilacis Glabrae 130g, Bark of Lindenleaf Torricellia again 130g, Radix viticis negundo 100g, Radix Ampelopsis delavayanae 80g, thin Caulis Piperis Boehmeriaefolii 50g, Herba Patriniae 70g, Radix Cypripedii Henryi 80g, Radix Vladimiriae 80g, Folium Styracis Suberifoliae 90g, Herba Serissae 70g, Radix Aristolochiae 70g, Juncus amplifolius A. Camus 50g, Rhizoma Kaempferiae 90g, Sarcococca ruscifolia Stapf 50g, Folium Ilicis Pubescentis 30g, Radix Zanthoxyli Spinifolii 40g, Herba galinsogae parviflorae 20g, Folium Trachycarpi 40g merge, and add and the soak by water that medical material weight ratio is 12 times amount 2 times, each 2h, filter, merging filtrate, filtrate Being performing centrifugal separation on processing, centrifugal rotational speed is 5000r/min, centrifugation time 20min, and filtrate concentrating under reduced pressure becomes relative density be 1.30～1.40 thick pastes, add above-mentioned steps fine powder (1), after mix homogeneously, are dried to dry extract in reduced vacuum 70 DEG C, and Pulverizing and sieving, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add starch, stearic Acid magnesium makes 1000 tablets.

Prepared by the drop pill of embodiment 4 Chinese medicine of the present invention

(1), take Rhizoma Curcumae Longae 160g, Endoconcha Sepiae 70g, Concha Arcae 60g, be ground into 120 (mesh) fine powder；

(2), take again Rhizoma Coptidis 190g, Fructus Hedychii Spicati 170g, Folium Fortunellae Margarita 180g, Fructus Hippophae 150g, Rhizoma Smilacis Glabrae 120g, Bark of Lindenleaf Torricellia 120g, Radix viticis negundo 80g, Radix Ampelopsis delavayanae 100g, thin Caulis Piperis Boehmeriaefolii 60g, Herba Patriniae 60g, Radix Cypripedii Henryi 90g, Radix Vladimiriae 90g, Folium Styracis Suberifoliae 70g, Herba Serissae 90g, Radix Aristolochiae 70g, Juncus amplifolius A. Camus 60g, Rhizoma Kaempferiae 80g, Sarcococca ruscifolia Stapf 40g, Folium Ilicis Pubescentis 40g, Radix Zanthoxyli Spinifolii 20g, Herba galinsogae parviflorae 30g, palm fibre Palmitic acid leaf 40g, adds and the soak by water that medical material weight ratio is 11 times amount 2 times, each 2h, filters, and merging filtrate, filtrate is performing centrifugal separation on Processing, centrifugal rotational speed is 4000r/min, centrifugation time 30min, and it is 1.30～1.40 that filtrate concentrating under reduced pressure becomes relative density Thick paste, adds above-mentioned steps fine powder (1), after mix homogeneously, is dried to dry extract in reduced vacuum 65 DEG C, and pulverizes and sieves, Dried cream powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add PEG4000 and PEG6000, after mix homogeneously, drips and makes 1000 drop pills.

In order to verify the curative effect of finished product of the present invention further, we are by the finished capsule product of preparation in above-mentioned specific embodiment 1 Agent medicine has carried out corresponding clinical trial, now result is reported as follows.

The clinical observation to patients w ith peptic ulcer disease of 1 Chinese medicine of the present invention

1.1 physical data

Accept patients w ith peptic ulcer disease totally 158 example for medical treatment, with reference to the Gastric Ulcer standard in " Chinese and western medicine clinic disease for digest ".In conjunction with Clinical manifestation and gastroscopy are made a definite diagnosis.It is randomly divided into treatment group 81 example and matched group 77 example.Treatment group age 26～68 years old, averagely Year at age (45.1 ± 2.7), the course of disease 6 months～4 years, average course of disease (2.3 ± 1.1) year；Matched group is age 27～71 years old, flat All the age (43.7 ± 3.1) year, the course of disease 8 months～6 years, average course of disease (2.6 ± 1.3) year, two groups of patient ages, the course of disease, diseases Through statistical procedures no significant difference (P ＞ 0.05) between feelings degree, there is comparability.

1.2 diagnostic criteria

The most all patients all have stomachache in various degree, belch, regurgitation, Nausea and vomiting, ballooning, thin white fur of tongue, arteries and veins Heavy, pale complexion.(2) gastroscopy: under gastroscope visible stomach or duodenal site have hyperemia in various degree, edema and Erosion, ulcer spot has the fraction of some larks to ooze out.

1.3 Therapeutic Method

Matched group: give WEIDE peace capsule (Meifeng Pharmaceutical Factory Fuzhou City of Jinting Pharmaceutical Co., Ltd.), oral medication, 3 Tablet/time, 3 times/d.

Treatment group: the capsule of the oral embodiment of the present invention 1 preparation, 3 tablets/time, 3 times/d.Two groups was all a treatment with 1 week Journey, takes continuously, 4 courses for the treatment of, disables other medicines during treatment, keeps happy, and diet is the lightest, avoid acid, peppery, cigarette, The irritable food such as wine, strong tea, terminates the course for the treatment of, further consultation after drug withdrawal January, and carries out electronic gastroscope check assessment curative effect, and at 6 Relapse rate is checked after Yue.

1.4 efficacy assessment standard

Curing: clinical symptom disappearance, gastroscope or x line check gastric mucosa recover normal；Take a turn for the better: clinical symptoms partial disappearance or Substantially alleviating, gastroscope or x line check gastric mucosa are obviously improved earlier above；Invalid: clinical symptoms without improve or gastroscope and x line check nothing Take a turn for the better.

2 therapeutic outcomes

2.1 liang of group patient clinical comparitive study the results are shown in Table 5.

5 liang of table group patient clinical comparitive study

From the experimental result of table 5, through the treatment of 4 courses for the treatment of, the clinical symptoms of most patients has different journey The improvement of degree, the total effective rate for the treatment of by Chinese herbs group of the present invention is 91.4%, and the patient taking matched group (WEIDE peace capsule) has Efficiency is only 68.8%.Result shows, the Chinese medicine of present invention clinical efficacy in terms for the treatment of gastric ulcer is notable, hence it is evident that excellent In matched group.

2.2 liang of group patients occur that untoward reaction and recurrence are shown in Table 6 over the course for the treatment of.

6 liang of table group adverse reactions of patients and recurrence compare

Result above table 6 shows, the Chinese medicine of the present invention has evident in efficacy, and have no adverse reaction the advantage low with relapse rate.

In sum, Chinese medicine of the present invention has obvious clinical effectiveness to gastric ulcer, is worth applying clinically and promoting.

Claims (7)

1. the Chinese medicine treating gastric ulcer, it is characterised in that it is made up of the crude drug of following weight portion: Rhizoma Coptidis, Fructus Tsaoko Medicine, Folium Fortunellae Margarita, Fructus Hippophae, Rhizoma Curcumae Longae, Rhizoma Smilacis Glabrae, Bark of Lindenleaf Torricellia, Radix viticis negundo, Radix Ampelopsis delavayanae, thin Caulis Piperis Boehmeriaefolii, Herba Patriniae, Radix Cypripedii Henryi, river wood Perfume, Folium Styracis Suberifoliae, Herba Serissae, Radix Aristolochiae, Juncus amplifolius A. Camus, Endoconcha Sepiae, Rhizoma Kaempferiae, Concha Arcae, Sarcococca ruscifolia Stapf, Folium Ilicis Pubescentis, Radix Zanthoxyli Spinifolii, spicy Grass, Folium Trachycarpi.

2. Chinese medicine as claimed in claim 1, it is characterised in that it is made up of the crude drug of following weight portion: Rhizoma Coptidis 170～ 190 parts, Fructus Hedychii Spicati 170～190 parts, Folium Fortunellae Margarita 170～190 parts, Fructus Hippophae 140～160 parts, Rhizoma Curcumae Longae 140～160 parts, Rhizoma Smilacis Glabrae 110～130 parts, Bark of Lindenleaf Torricellia 110～130 parts, Radix viticis negundo 80～100 parts, Radix Ampelopsis delavayanae 80～100 parts, thin Caulis Piperis Boehmeriaefolii 50～70 parts, Herba Patriniae 50～70 parts, Radix Cypripedii Henryi 80～100 parts, Radix Vladimiriae 80～100 parts, Folium Styracis Suberifoliae 70～90 parts, Herba Serissae 70～90 parts, green grass or young crops Fissistigma bracteolatum Chatt. 50～70 parts, Juncus amplifolius A. Camus 50～70 parts, Endoconcha Sepiae 50～70 parts, Rhizoma Kaempferiae 70～90 parts, Concha Arcae 50～70 parts, Sarcococca ruscifolia Stapf 30～50 parts, Folium Ilicis Pubescentis 30～50 parts, Radix Zanthoxyli Spinifolii 20～40 parts, Herba galinsogae parviflorae 20～40 parts, Folium Trachycarpi 20～40 parts.

3. Chinese medicine as claimed in claim 2, it is characterised in that it is made up of the crude drug of following weight portion: Rhizoma Coptidis 180 Part, Fructus Hedychii Spicati 180 parts, Folium Fortunellae Margarita 180 parts, Fructus Hippophae 150 parts, 150 parts of Rhizoma Curcumae Longae, Rhizoma Smilacis Glabrae 120 parts, Bark of Lindenleaf Torricellia 120 parts, Radix viticis negundo 90 parts, Radix Ampelopsis delavayanae 90 parts, thin Caulis Piperis Boehmeriaefolii 60 parts, Herba Patriniae 60 parts, Radix Cypripedii Henryi 90 parts, Radix Vladimiriae 90 parts, Folium Styracis Suberifoliae 80 parts, Herba Serissae 80 parts, Radix Aristolochiae 60 parts, Juncus amplifolius A. Camus 60 parts, Endoconcha Sepiae 60 parts, Rhizoma Kaempferiae 80 parts, Concha Arcae 60 parts, Sarcococca ruscifolia Stapf 40 parts, Folium Ilicis Pubescentis 40 parts, Radix Zanthoxyli Spinifolii 30 parts, Herba galinsogae parviflorae 30 parts, Folium Trachycarpi 30 parts.

4. the Chinese medicine as described in claims 1 to 3 is arbitrary, it is characterised in that described Chinese medicine can make capsule, granule, Tablet, drop pill.

5. Chinese medicine as claimed in claim 4, it is characterised in that described Chinese medicine is preferably capsule.

6. the preparation method of the Chinese medicine as described in claims 1 to 3 is arbitrary, it is characterised in that it is made up of the steps:

(1), take Rhizoma Curcumae Longae, Endoconcha Sepiae, Concha Arcae, be ground into fine powder；

(2), take Rhizoma Coptidis, Fructus Hedychii Spicati, Folium Fortunellae Margarita, Fructus Hippophae, Rhizoma Smilacis Glabrae, Bark of Lindenleaf Torricellia, Radix viticis negundo, Radix Ampelopsis delavayanae, thin Caulis Piperis Boehmeriaefolii, Herba Patriniae again Grass, Radix Cypripedii Henryi, Radix Vladimiriae, Folium Styracis Suberifoliae, Herba Serissae, Radix Aristolochiae, Juncus amplifolius A. Camus, Rhizoma Kaempferiae, Sarcococca ruscifolia Stapf, Folium Ilicis Pubescentis, Radix Zanthoxyli Spinifolii, spicy Grass, Folium Trachycarpi merge, and add and the soak by water that medical material weight ratio is 7～12 times amount 2 times, each 1～2h, filter, merging filtrate, filter Liquid is performing centrifugal separation on processing, and centrifugal rotational speed is 3000～5000r/min, and centrifugation time 20～40min, by filtrate concentrating under reduced pressure Becoming relative density is 1.30～1.40 thick pastes, adds above-mentioned steps fine powder (1), after mix homogeneously, in reduced vacuum 60～70 DEG C Being dried to dry extract, and pulverize and sieve, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add on pharmaceutics conventional Adjuvant make various different oral formulations, to obtain final product.

7. the preparation method of Chinese medicine as claimed in claim 6, it is characterised in that it is made up of the steps:

(1), take Rhizoma Curcumae Longae, Endoconcha Sepiae, Concha Arcae, be ground into 120 (mesh) fine powder；

(2), take Rhizoma Coptidis, Fructus Hedychii Spicati, Folium Fortunellae Margarita, Fructus Hippophae, Rhizoma Smilacis Glabrae, Bark of Lindenleaf Torricellia, Radix viticis negundo, Radix Ampelopsis delavayanae, thin Caulis Piperis Boehmeriaefolii, Herba Patriniae again Grass, Radix Cypripedii Henryi, Radix Vladimiriae, Folium Styracis Suberifoliae, Herba Serissae, Radix Aristolochiae, Juncus amplifolius A. Camus, Rhizoma Kaempferiae, Sarcococca ruscifolia Stapf, Folium Ilicis Pubescentis, Radix Zanthoxyli Spinifolii, spicy Grass, Folium Trachycarpi merge, and add and the soak by water that medical material weight ratio is 10 times amount 2 times, each 1.5h, filter, merging filtrate, filtrate warp Centrifuging treatment, centrifugal rotational speed is 4000r/min, centrifugation time 30min, and filtrate concentrating under reduced pressure becomes relative density be 1.30～1.40 thick pastes, add above-mentioned steps fine powder (1), after mix homogeneously, are dried to dry extract in reduced vacuum 65 DEG C, and Pulverizing and sieving, get dry extract powder；

, take above-mentioned steps (2) in dried cream powder, fully after mixing, obtain active ingredient of Chinese herbs, add on pharmaceutics conventional Adjuvant make various different oral formulations, to obtain final product.