CN106109987A - A kind of repair liquid after operation on oral cavity - Google Patents
A kind of repair liquid after operation on oral cavity Download PDFInfo
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- CN106109987A CN106109987A CN201610486589.XA CN201610486589A CN106109987A CN 106109987 A CN106109987 A CN 106109987A CN 201610486589 A CN201610486589 A CN 201610486589A CN 106109987 A CN106109987 A CN 106109987A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Abstract
The invention discloses the repair liquid after a kind of operation on oral cavity, be made up of following raw material: Cordia dichotoma, Herba Alii fistulosi, sourwood slurry, Herba suadeae glaucae, salt mugwort, Wild soybean, Malus komarovii, Herba Pratiae Nummulariae, SONGGUOJU, Pollen Typhae, Folium Arundinis donacis, Herba Desmodii Styracifolii, Herba Haloragidis Micranthae, oligofructose, Sal Ammoniacus, pyrolusitum, purplish red salt, cellulase, pectase, zymosan, Semen sojae atricolor polysaccharide.Repair liquid after the operation on oral cavity that the present invention provides, curative effect is quick, and effective percentage is up to 100%, and cure rate is 94%；Zymosan extracts through pure natural, and safety and Health has no side effect, and extraction ratio is up to 26.4%；All Chinese medicines are through repeatedly extracting and purification, and yield improves 14.9%；Fragrant in taste is light sweet, and without Chinese medicine abnormal flavour, patient does not have conflict sense, uses simple, start with from oral focus, regulate function, coordinate endocrine, enhancing immunity, inhibiting bacteria and diminishing inflammation, fundamentally alleviates oral cavity and the malaise symptoms of gastrointestinal, reaches postoperation of oral cavity and repairs purpose.
Description
Technical field
The invention mainly relates to pharmaceutical technology field, particularly relate to the repair liquid after a kind of operation on oral cavity.
Background technology
Although operation on oral cavity is little, but postoperative being easy to infects.After clinic operation, almost all utilization is eaten big at present
Amount Western medicine suppresses postoperative infection, and western medicine result is single, easily develops immunity to drugs, and can not solve postoperative to cause because of anesthesia
Oral cavity and gastrointestinal upset, the most simple carries out antiinflammatory for focus.Therefore, patient needs one badly and can suppress postoperative sense
Dye, can improve again oral cavity and gastrointestinal upset that patient causes because of operating medicine.
Repair liquid after the operation on oral cavity that the present invention provides, not just for the focus of operation on oral cavity, moreover it is possible to carry out whole body
Conditioning, easy to use, curative effect is obvious, cheap, solves a great problem that postoperation of oral cavity is repaired clinically.
Summary of the invention
In order to make up the defect of prior art, it is an object of the invention to provide the repair liquid after a kind of operation on oral cavity.
Repair liquid after a kind of operation on oral cavity, is made up of the raw material of following weight portion: Cordia dichotoma 17 ~ 19, Herba Alii fistulosi 16 ~ 18,
Sourwood slurry 15 ~ 17, Herba suadeae glaucae 13 ~ 15, salt mugwort 12 ~ 14, Wild soybean 12 ~ 14, Malus komarovii 11 ~ 13, Herba Pratiae Nummulariae 11 ~ 13, strobile
Chrysanthemum 10 ~ 12, Pollen Typhae 10 ~ 12, Folium Arundinis donacis 9 ~ 11, Herba Desmodii Styracifolii 9 ~ 11, Herba Haloragidis Micranthae 9 ~ 11, oligofructose 7 ~ 9, Sal Ammoniacus 6 ~ 8,
Pyrolusitum 4 ~ 6, purplish red salt 4 ~ 6, cellulase 0.24 ~ 0.26, pectase 0.13 ~ 0.15, zymosan 0.07 ~ 0.09, Semen sojae atricolor
Polysaccharide 0.05 ~ 0.07.
Preferably, the described repair liquid after operation on oral cavity, it is made up of the raw material of following weight portion: Cordia dichotoma 19, Herba Alii fistulosi
18, sourwood slurry 17, Herba suadeae glaucae 15, salt mugwort 14, Wild soybean 14, Malus komarovii 13, Herba Pratiae Nummulariae 12, SONGGUOJU 12, Pollen Typhae 10, Arundo donax
Leaf 10, Herba Desmodii Styracifolii 9, Herba Haloragidis Micranthae 9, oligofructose 8, Sal Ammoniacus 8, pyrolusitum 6, purplish red salt 6, cellulase 0.25, pectin
Enzyme 0.14, zymosan 0.08, Semen sojae atricolor polysaccharide 0.06.
Described zymosan, takes one or more in wine yeast, beer yeast, bakery yeast, is enlarged
Cultivating, 8000 revs/min are centrifugal 15 minutes, obtain yeast paste, add the pure water of yeast paste weight 2 times amount, mix homogeneously, and 8000
Revs/min centrifugal 15 minutes, repeated washing 2 times, obtain yeast raw material, yeast raw material is placed in-42 ~-40 DEG C of freezings 3 ~ 4 hours,
Take out, add the edible alkali solution that mass fraction is 6 ~ 8% of yeast raw material weight 2 ~ 3 times amount, ice bath, be placed in cell crushing instrument
In, 560 ~ 580w crushes 7 seconds, stops 3 seconds, repeatedly crushes 40 times, and adding mass fraction is 10 ~ 12% acetums, and tune pH is
6.4 ~ 6.8,10000 revs/min are centrifuged 10 minutes, take supernatant, add the volume of supernatant volume 3 ~ 4 times amount in supernatant
The ethanol solution of mark 90 ~ 92%, is placed in 3 ~ 5 DEG C and precipitates 16 ~ 18 hours, and 6000 revs/min are centrifugal 15 minutes, takes precipitation, and-44
~-42 DEG C of lyophilizations are to without moisture, and without toxic reagent, safety and Health, extraction ratio is high, obtains zymosan.
A kind of preparation method of the repair liquid after operation on oral cavity, its concrete steps include:
(1) by Cordia dichotoma, Herba Alii fistulosi, sourwood slurry, Herba suadeae glaucae, salt mugwort, Wild soybean, Malus komarovii, Herba Pratiae Nummulariae, SONGGUOJU, Pollen Typhae, reed
Folium Bambusae, Herba Desmodii Styracifolii and Herba Haloragidis Micranthae are pulverized, and cross 80 ~ 100 mesh sieves, obtain vegetable material powder, add vegetable material grain weight amount 3 ~ 4 times amount
Distilled water, 42 ~ 44 DEG C of water-baths, add cellulase and pectase, 36 ~ 38 revs/min are stirred enzymolysis 220 ~ 240 minutes, destroy
Organization structure of the plant, improves extraction ratio, obtains plant enzymolysis material；
(2) plant enzymolysis material being placed in 80 ~ 85 DEG C of water-baths, the ultrasonic extraction of 34 ~ 36kHz 35 ~ 40 minutes, 5000 revs/min are centrifuged
10 minutes, obtain extracting solution A and plant medicine dregs A, the distilled water of addition plant medicine dregs A weight 2 ~ 3 times amount in plant medicine dregs A, 33 ~
The ultrasonic extraction of 35kHz 25 ~ 30 minutes, 6000 revs/min are centrifuged 10 minutes, obtain extracting solution B and plant medicine dregs B, to plant medicine dregs B
The alcoholic solution that volume fraction is 75 ~ 77% of middle addition plant medicine dregs B weight 2 ~ 3 times amount, airtight, 62 ~ 64 DEG C of water-baths, 28 ~
The ultrasonic extraction of 30kHz 30 ~ 35 minutes, 8000 revs/min are centrifuged 10 minutes, obtain extracting solution C and plant medicine dregs C, merge all carrying
Take liquid, cross 120 ~ 140 mesh sieves, be placed in 80 ~ 85 DEG C of baking ovens, be concentrated into the 1/3 of original volume, obtain plant extraction liquid；
(3) Sal Ammoniacus, pyrolusitum and purplish red salt are pulverized, cross 80 ~ 100 mesh sieves, obtain stone powder, add stone powder weight 4 ~ 5 times amount
Water, big fire boils, little fire infusion 30 ~ 35 minutes, takes out supernatant, again adds water, and repeats infusion and extracts 3 times, merges all enduring
Boil liquid, cross the filter membrane of 0.22 μm, be concentrated into 2 times of stone powder weight, obtain stone powder extracting solution；
(4) by plant extraction liquid and stone powder extracting solution mix homogeneously, obtain Chinese medicine extraction liquid, in Chinese medicine extraction liquid, add Chinese medicine carry
Taking liquid and amass the ether of 1/5 amount, 48 ~ 50 revs/min shake 40 ~ 50 minutes, stand 20 ~ 30 minutes, separate ether layer and water layer,
Retaining water layer, obtain water layer extracting solution, added in the bag filter that molecular weight is 32kD by water layer extracting solution, flowing water dialysis 22 ~ 24 is little
Time, take out, be concentrated in vacuo to the 1/2 of all raw material weights in-42 ~-40 DEG C, add oligofructose, zymosan and Semen sojae atricolor many
Sugar, obtains the repair liquid after operation on oral cavity；
(5) it is divided into 150 parts, is prepared as preparation, packaging, 36 ~ 38 DEG C, 119 ~ 121MPa ultrahigh-pressure sterilization 20 ~ 25 minutes, must become
Product.
The described repair liquid after operation on oral cavity, using method is every 4 hours spout chambeies 1 time, spray 1 part every time.
The invention have the advantage that the repair liquid after a kind of operation on oral cavity that the present invention provides, abundant raw material, curative effect is quick,
Effective percentage is up to 100%, and cure rate is 94%；Raw material is easy to get, cheap, alleviates the financial burden of patient；Zymosan is through pure
Natural extract, safety and Health, have no side effect, extraction ratio is up to 26.4%, increases operation rate；All Chinese medicines through repeatedly extract and
Purification, yield improves 14.9%, saves a large amount of production cost；Fragrant in taste is light sweet, and without Chinese medicine abnormal flavour, patient does not have conflict sense,
Using simple, it is possible to start with from oral focus, regulate function, coordinate endocrine, enhancing immunity, inhibiting bacteria and diminishing inflammation, from root
Alleviate oral cavity and the malaise symptoms of gastrointestinal in basis, reach postoperation of oral cavity and repair purpose.
Detailed description of the invention
With specific embodiment, the present invention is described below.
Embodiment
Repair liquid after a kind of operation on oral cavity, is made up of the raw material of following weight portion: Cordia dichotoma 19, Herba Alii fistulosi 18, sourwood slurry
17, Herba suadeae glaucae 15, salt mugwort 14, Wild soybean 14, Malus komarovii 13, Herba Pratiae Nummulariae 12, SONGGUOJU 12, Pollen Typhae 10, Folium Arundinis donacis 10, extensively gold
Money grass 9, Herba Haloragidis Micranthae 9, oligofructose 8, Sal Ammoniacus 8, pyrolusitum 6, purplish red salt 6, cellulase 0.25, pectase 0.14, ferment
Female polysaccharide 0.08, Semen sojae atricolor polysaccharide 0.06.
Described zymosan, takes one or more in wine yeast, beer yeast, bakery yeast, is enlarged
Cultivating, 8000 revs/min are centrifugal 15 minutes, obtain yeast paste, add the pure water of yeast paste weight 2 times amount, mix homogeneously, and 8000
Revs/min centrifugal 15 minutes, repeated washing 2 times, obtain yeast raw material, yeast raw material is placed in-40 DEG C of freezings 4 hours, take out, add
Entering the edible alkali solution that mass fraction is 8% of yeast raw material weight 3 times amount, ice bath, be placed in cell crushing instrument, 580w crushes 7
Second, stop 3 seconds, repeatedly crush 40 times, adding mass fraction is 12% acetum, adjusts pH to be 6.8,10000 revs/min and is centrifuged
10 minutes, take supernatant, in supernatant, add the ethanol solution of the volume fraction 90% of supernatant volume 4 times amount, be placed in 3 DEG C
Precipitating 18 hours, 6000 revs/min are centrifuged 15 minutes, take precipitation, and-42 DEG C of lyophilizations are to without moisture, without toxic reagent, safety
Health, extraction ratio is high, obtains zymosan.
A kind of preparation method of the repair liquid after operation on oral cavity, its concrete steps include:
(1) by Cordia dichotoma, Herba Alii fistulosi, sourwood slurry, Herba suadeae glaucae, salt mugwort, Wild soybean, Malus komarovii, Herba Pratiae Nummulariae, SONGGUOJU, Pollen Typhae, reed
Folium Bambusae, Herba Desmodii Styracifolii and Herba Haloragidis Micranthae are pulverized, and cross 100 mesh sieves, obtain vegetable material powder, add the distillation of vegetable material grain weight amount 3 times amount
Water, 42 DEG C of water-baths, add cellulase and pectase, 36 revs/min are stirred enzymolysis 220 minutes, destroy organization structure of the plant, carry
High extraction, obtains plant enzymolysis material；
(2) plant enzymolysis material is placed in 85 DEG C of water-baths, the ultrasonic extraction of 34kHz 40 minutes, 5000 revs/min are centrifuged 10 minutes,
Extracting solution A and plant medicine dregs A, adds the distilled water of plant medicine dregs A weight 2 times amount, the ultrasonic extraction of 33kHz in plant medicine dregs A
30 minutes, 6000 revs/min were centrifuged 10 minutes, obtain extracting solution B and plant medicine dregs B, added plant medicine dregs B in plant medicine dregs B
The alcoholic solution that volume fraction is 77% of weight 3 times amount, airtight, 62 DEG C of water-baths, the ultrasonic extraction of 30kHz 35 minutes, 8000 turns/
Minutes centrifugal 10 minutes, obtain extracting solution C and plant medicine dregs C, merge all extracting solution, cross 140 mesh sieves, be placed in 85 DEG C of baking ovens, dense
It is reduced to the 1/3 of original volume, obtains plant extraction liquid；
(3) Sal Ammoniacus, pyrolusitum and purplish red salt are pulverized, cross 100 mesh sieves, obtain stone powder, add the water of stone powder weight 5 times amount, greatly
Fire boils, little fire infusion 30 minutes, takes out supernatant, again adds water, and repeats infusion and extracts 3 times, merges all infusion liquid, mistake
The filter membrane of 0.22 μm, is concentrated into 2 times of stone powder weight, obtains stone powder extracting solution；
(4) by plant extraction liquid and stone powder extracting solution mix homogeneously, obtain Chinese medicine extraction liquid, in Chinese medicine extraction liquid, add Chinese medicine carry
Taking liquid and amass the ether of 1/5 amount, 50 revs/min shake 40 minutes, stand 20 ~ 30 minutes, separate ether layer and water layer, retain water
Layer, obtains water layer extracting solution, is added in the bag filter that molecular weight is 32kD by water layer extracting solution, and flowing water is dialysed 24 hours, takes out,
It is concentrated in vacuo to the 1/2 of all raw material weights in-40 DEG C, adds oligofructose, zymosan and Semen sojae atricolor polysaccharide, obtain operation on oral cavity
After repair liquid；
(5) it is divided into 150 parts, is prepared as preparation, packaging, 36 DEG C, 119MPa ultrahigh-pressure sterilization 20 minutes, obtain finished product.
Comparative example
Reparation Western medicine after commercially available common operation on oral cavity.
Embodiment and the fungistatic effect of comparative example medicament:
Respectively Example and the medicament 100 of comparative example, adds the distilled water diluting of equivalent, mix homogeneously, add Lactobacillus brevis,
In facultative diphtheroid, model Yong Shi coccus and staphylococcic culture dish, carry out bacteriostatic test, cultivate 12 ~ 14 hours, utilize
The diameter of vernier caliper measurement inhibition zone, the fungistatic effect of embodiment and comparative example medicament is shown in Table 1.
Table 1: embodiment and the fungistatic effect of comparative example medicament
As it can be seen from table 1 the repair liquid after the operation on oral cavity of embodiment, act on Lactobacillus brevis, facultative diphtheroid, model
Yong Shi coccus and staphylococcus, each antibacterial antibacterial circle diameter of embodiment is all significantly greater than comparative example, the inhibition to antibacterial
It is substantially better than comparative example, illustrates that the repair liquid after embodiment operation on oral cavity has obvious fungistatic effect.
Embodiment and the effect of comparative example medicament reparation gastrointestinal function:
Usage and dosage: every 4 hours spout chambeies 1 time, spray 1 part, uses 10 days every time.
Test case:
Curative effect determinate standard:
Effective: oral cavity and gastrointestinal upset symptom alleviate, and have taken a turn for the better；
Cure: oral cavity and gastrointestinal upset transference cure.
Randomly choosing patient 200 example, the standard of selection is: meet Western medicine diagnose standard and differential diagnosis in tcm standard, age exist
Between 18 ~ 55 years old, wherein, women 100 example, male 100 example.Above-mentioned case is divided into embodiment group and comparative example group, respectively at random
100 people, men and women half and half, and embodiment and comparative example medicament are repaired the effect of gastrointestinal function and be shown in Table 2.
Table 2: the effect of gastrointestinal function repaired by embodiment and comparative example medicament
| Project | Patient's number | Effectively/(%) | Cure/(%) | Onset time/(hour) |
| Embodiment group | 100 | 100 | 94 | 2 |
| Comparative example group | 100 | 8 | 2 | 2 |
From table 2 it can be seen that the repair liquid after the operation on oral cavity of embodiment, the effective percentage improving gastrointestinal upset symptom is
100%, cure rate is 94%, and action effect is fast, illustrates that the repair liquid after embodiment operation on oral cavity has obvious postoperation of oral cavity and repaiies
Multiple effect.
Claims (5)
1. the repair liquid after an operation on oral cavity, it is characterised in that be made up of the raw material of following weight portion: Cordia dichotoma 17 ~ 19,
Herba Alii fistulosi 16 ~ 18, sourwood slurry 15 ~ 17, Herba suadeae glaucae 13 ~ 15, salt mugwort 12 ~ 14, Wild soybean 12 ~ 14, Malus komarovii 11 ~ 13, Herba Pratiae Nummulariae 11 ~
13, SONGGUOJU 10 ~ 12, Pollen Typhae 10 ~ 12, Folium Arundinis donacis 9 ~ 11, Herba Desmodii Styracifolii 9 ~ 11, Herba Haloragidis Micranthae 9 ~ 11, oligofructose 7 ~ 9, purple
Sal Ammoniacus 6 ~ 8, pyrolusitum 4 ~ 6, purplish red salt 4 ~ 6, cellulase 0.24 ~ 0.26, pectase 0.13 ~ 0.15, zymosan 0.07 ~
0.09, Semen sojae atricolor polysaccharide 0.05 ~ 0.07.
Repair liquid after operation on oral cavity the most according to claim 1, it is characterised in that by the raw material system of following weight portion
Become: Cordia dichotoma 19, Herba Alii fistulosi 18, sourwood slurry 17, Herba suadeae glaucae 15, salt mugwort 14, Wild soybean 14, Malus komarovii 13, Herba Pratiae Nummulariae 12, strobile
Chrysanthemum 12, Pollen Typhae 10, Folium Arundinis donacis 10, Herba Desmodii Styracifolii 9, Herba Haloragidis Micranthae 9, oligofructose 8, Sal Ammoniacus 8, pyrolusitum 6, purplish red salt 6, fibre
Dimension element enzyme 0.25, pectase 0.14, zymosan 0.08, Semen sojae atricolor polysaccharide 0.06.
Repair liquid after operation on oral cavity the most according to claim 1, it is characterised in that described zymosan, takes Fructus Vitis viniferae
One or more in brewer yeast, beer yeast, bakery yeast, are enlarged cultivating, and 8000 revs/min are centrifuged 15 minutes,
Yeast paste, adds the pure water of yeast paste weight 2 times amount, mix homogeneously, and 8000 revs/min are centrifuged 15 minutes, repeated washing 2
Secondary, obtain yeast raw material, yeast raw material is placed in-42 ~-40 DEG C of freezings 3 ~ 4 hours, take out, add yeast raw material weight 2 ~ 3 times amount
The edible alkali solution that mass fraction is 6 ~ 8%, ice bath, be placed in cell crushing instrument, 560 ~ 580w crushes 7 seconds, stops 3 seconds, instead
Crushing again 40 times, adding mass fraction is 10 ~ 12% acetums, adjusts pH to be 6.4 ~ 6.8,10000 revs/min and is centrifuged 10 minutes,
Take supernatant, in supernatant, add the ethanol solution of the volume fraction 90 ~ 92% of supernatant volume 3 ~ 4 times amount, be placed in 3 ~ 5 DEG C
Precipitating 16 ~ 18 hours, 6000 revs/min are centrifuged 15 minutes, take precipitation, and-44 ~-42 DEG C of lyophilizations, to without moisture, obtain yeast many
Sugar.
The preparation method of the repair liquid after operation on oral cavity the most according to claim 1, it is characterised in that comprise the following steps:
(1) by Cordia dichotoma, Herba Alii fistulosi, sourwood slurry, Herba suadeae glaucae, salt mugwort, Wild soybean, Malus komarovii, Herba Pratiae Nummulariae, SONGGUOJU, Pollen Typhae, reed
Folium Bambusae, Herba Desmodii Styracifolii and Herba Haloragidis Micranthae are pulverized, and cross 80 ~ 100 mesh sieves, obtain vegetable material powder, add vegetable material grain weight amount 3 ~ 4 times amount
Distilled water, 42 ~ 44 DEG C of water-baths, add cellulase and pectase, 36 ~ 38 revs/min are stirred enzymolysis 220 ~ 240 minutes, must plant
Thing enzymolysis material；
(2) plant enzymolysis material being placed in 80 ~ 85 DEG C of water-baths, the ultrasonic extraction of 34 ~ 36kHz 35 ~ 40 minutes, 5000 revs/min are centrifuged
10 minutes, obtain extracting solution A and plant medicine dregs A, the distilled water of addition plant medicine dregs A weight 2 ~ 3 times amount in plant medicine dregs A, 33 ~
The ultrasonic extraction of 35kHz 25 ~ 30 minutes, 6000 revs/min are centrifuged 10 minutes, obtain extracting solution B and plant medicine dregs B, to plant medicine dregs B
The alcoholic solution that volume fraction is 75 ~ 77% of middle addition plant medicine dregs B weight 2 ~ 3 times amount, airtight, 62 ~ 64 DEG C of water-baths, 28 ~
The ultrasonic extraction of 30kHz 30 ~ 35 minutes, 8000 revs/min are centrifuged 10 minutes, obtain extracting solution C and plant medicine dregs C, merge all carrying
Take liquid, cross 120 ~ 140 mesh sieves, be placed in 80 ~ 85 DEG C of baking ovens, be concentrated into the 1/3 of original volume, obtain plant extraction liquid；
(3) Sal Ammoniacus, pyrolusitum and purplish red salt are pulverized, cross 80 ~ 100 mesh sieves, obtain stone powder, add stone powder weight 4 ~ 5 times amount
Water, big fire boils, little fire infusion 30 ~ 35 minutes, takes out supernatant, again adds water, and repeats infusion and extracts 3 times, merges all enduring
Boil liquid, cross the filter membrane of 0.22 μm, be concentrated into 2 times of stone powder weight, obtain stone powder extracting solution；
(4) by plant extraction liquid and stone powder extracting solution mix homogeneously, obtain Chinese medicine extraction liquid, in Chinese medicine extraction liquid, add Chinese medicine carry
Taking liquid and amass the ether of 1/5 amount, 48 ~ 50 revs/min shake 40 ~ 50 minutes, stand 20 ~ 30 minutes, separate ether layer and water layer,
Retaining water layer, obtain water layer extracting solution, added in the bag filter that molecular weight is 32kD by water layer extracting solution, flowing water dialysis 22 ~ 24 is little
Time, take out, be concentrated in vacuo to the 1/2 of all raw material weights in-42 ~-40 DEG C, add oligofructose, zymosan and Semen sojae atricolor many
Sugar, obtains the repair liquid after operation on oral cavity；
(5) it is divided into 150 parts, is prepared as preparation, packaging, 36 ~ 38 DEG C, 119 ~ 121MPa ultrahigh-pressure sterilization 20 ~ 25 minutes, must become
Product.
5. according to the instructions of taking of the repair liquid after operation on oral cavity described in claim 1 ~ 4, it is characterised in that every spray in 4 hours
1 time, oral cavity, every time spray 1 part.
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| CN201610486589.XA CN106109987A (en) | 2016-06-29 | 2016-06-29 | A kind of repair liquid after operation on oral cavity |
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| CN201610486589.XA CN106109987A (en) | 2016-06-29 | 2016-06-29 | A kind of repair liquid after operation on oral cavity |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040712A (en) * | 2012-12-26 | 2013-04-17 | 南京恒青楼宇设备有限公司青岛分公司 | Mouth wash |
| CN104127586A (en) * | 2014-08-13 | 2014-11-05 | 陈林旭 | Mouth wash capable of inhibiting gum bleeding and preparation method thereof |
| CN104306711A (en) * | 2014-09-22 | 2015-01-28 | 济南前程知识产权咨询有限公司 | Traditional Chinese medicine for treating oral ulcer |
| CN105030594A (en) * | 2015-07-13 | 2015-11-11 | 王学香 | Cassia fistula herbal gargle and method for preparing same |
| CN105287328A (en) * | 2015-09-23 | 2016-02-03 | 王进 | Manuka honey toothpaste for pregnant women and preparation method of toothpaste |
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2016
- 2016-06-29 CN CN201610486589.XA patent/CN106109987A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040712A (en) * | 2012-12-26 | 2013-04-17 | 南京恒青楼宇设备有限公司青岛分公司 | Mouth wash |
| CN104127586A (en) * | 2014-08-13 | 2014-11-05 | 陈林旭 | Mouth wash capable of inhibiting gum bleeding and preparation method thereof |
| CN104306711A (en) * | 2014-09-22 | 2015-01-28 | 济南前程知识产权咨询有限公司 | Traditional Chinese medicine for treating oral ulcer |
| CN105030594A (en) * | 2015-07-13 | 2015-11-11 | 王学香 | Cassia fistula herbal gargle and method for preparing same |
| CN105287328A (en) * | 2015-09-23 | 2016-02-03 | 王进 | Manuka honey toothpaste for pregnant women and preparation method of toothpaste |
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Application publication date: 20161116 |