CN106109867A - A kind of Chinese medicine preparation for the treatment of venereal and Dermatology and its preparation method and application - Google Patents
A kind of Chinese medicine preparation for the treatment of venereal and Dermatology and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind for the treatment of venereal Chinese medicine preparation with Dermatology and its preparation method and application, this Chinese medicine preparation, is made up of according to the raw material of weight portion following: Fructus Leonuri 10 18 parts, stick grass 16 24 parts, Bulbus Allii Macrostemonis 22 30 parts, the Radix Angelicae Dahuricae 20 28 parts, Radix Codonopsis 18 parts.Stick grass, the Radix Angelicae Dahuricae are pulverized, sieved, adds sodium bicarbonate aqueous solution heated and stirred and process, cross leaching filtrate；Fructus Leonuri, Bulbus Allii Macrostemonis are pulverized, sieved, adds 70% ethanol solution and extract 2 times, be concentrated to give concentrated solution；Radix Codonopsis is pulverized, sieved, adds citric acid alcoholic solution heated and stirred, drying Radix Codonopsis powder；Filtrate is stirred with concentrated solution Hybrid Heating, is subsequently adding Radix Codonopsis powder stirring, carries out microwave treatment, drying.The present invention have draw out pus by applying a plaster to the affected part, sterilize, antiinflammatory relieves the pain, the curative effect of reparative regeneration, to the Dermatology determined curative effect suffering from sexually transmitted disease (STD) and sexually transmitted disease (STD) causes, cure rate is high, instant effect, has no side effect, reduces treatment cost, is suitable for many people and uses.
Description
Technical field
The present invention relates to pharmaceutical technology field, a kind for the treatment of venereal and the Chinese medicine preparation of Dermatology and preparation thereof
Methods and applications.
Background technology
Sexually transmitted disease (STD) (venereal disease) traditional view refers to the disease infected by sex act, and major lesions occurs
At genital area.Sexually transmitted disease (STD) has kind more than 20, common male venereal disease to have syphilis, gonorrhea, chancroid, granuloma inguinale, pouring
Bar granuloma, condyloma acuminatum, genital herpes, chlamydial urogenital infections, mycoplasma urogenital infections and
AIDS etc..Wherein, syphilis, gonorrhea, genital herpes, condyloma acuminatum, chancroid, hodgkin and acquired immune deficiency syndrome (AIDS) sexually transmitted disease (STD) quilt
It is classified as the sexually transmitted disease (STD) of China's keypoint control.The preventing and controlling of sexually transmitted disease (STD) will be a task the most arduous and long-term.Sexually transmitted disease (STD) is to human body
Healthy infringement is many.Skin is caused the Dermatologies such as redness, pruritus to occur, if can not send out in time after venereal infection
Now and thoroughly treating, not only can damage the genitals of people, cause sterile, some also can damage the important of the human body such as heart, brain
Organ, even results in death.
Doctor trained in Western medicine uses antibiotics, antibiotic, instant effect more to the treatment of sexually transmitted disease (STD), can tackle mitogenetic sporozoite and the body of sexually transmitted disease (STD)
Interior major part is viral, pathogenic bacteria.But, the drug effect time of staying in vivo antibacterial, antibiotic is the shortest, the rear ease sporozoite to sexually transmitted disease (STD)
It is unable to reach elimination with dormancy sporozoite, the pathogenic bacteria outside vagina and outside penis, scrotum skin also cannot be eliminated.The outer focus of doctor trained in Western medicine Zhi Pi
The laser surgery and the excision that use advanced person are all fine, but the virus and bacteria that focus is peripheral is not reached removing purpose.Can not
Eliminate the virocyte of sexually transmitted disease (STD) residual completely, still have recurrence, cause sexually transmitted disease (STD) long-term existence to become disease and be difficult to treat.And it is existing at present
Various Chinese herbal medicines, medicine time is long, need to be used as medicine with rare medicinal herbs, and curative effect is the most undesirable.
Summary of the invention
It is an object of the invention to provide a kind of cure rate height, instant effect, the treating venereal of the cost that has no side effect, reduces
Chinese medicine preparation with Dermatology and its preparation method and application, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind for the treatment of venereal and the Chinese medicine preparation of Dermatology, be made up of according to the raw material of weight portion following: Fructus Leonuri 10-
18 parts, stick grass 16-24 part, Bulbus Allii Macrostemonis 22-30 part, Radix Angelicae Dahuricae 20-28 part, Radix Codonopsis 1-8 part.
As the further scheme of the present invention: described treating venereal and the Chinese medicine preparation of Dermatology, by following according to weight
The raw material composition of amount part: Fructus Leonuri 12-16 part, stick grass 18-22 part, Bulbus Allii Macrostemonis 24-28 part, Radix Angelicae Dahuricae 22-26 part, Radix Codonopsis 3-6 part.
As the further scheme of the present invention: described treating venereal and the Chinese medicine preparation of Dermatology, by following according to weight
The raw material composition of amount part: Fructus Leonuri 14 parts, stick grass 20 parts, Bulbus Allii Macrostemonis 26 parts, the Radix Angelicae Dahuricae 24 parts, Radix Codonopsis 5 parts.
Another object of the present invention is to provide the preparation method of a kind for the treatment of venereal and the Chinese medicine preparation of Dermatology, by following
Step forms:
1) stick grass, the Radix Angelicae Dahuricae are pulverized, crossed 100 mesh sieves, add the sodium bicarbonate aqueous solution of the two quality 10 times, bicarbonate
In sodium water solution, sodium bicarbonate mass content is 5-6%, and at 50-52 DEG C, heated and stirred processes 2.5-2.6h, then at 72-75 DEG C
Lower heated and stirred 1.5-1.6h, then stir process 0.6-0.8h at 92-95 DEG C, cross leaching filtrate；
2) Fructus Leonuri, Bulbus Allii Macrostemonis being pulverized, cross 80 mesh sieves, 70% ethanol solution adding the two quality 5-6 times extracts 2 times,
Extraction temperature is 75-78 DEG C, and extraction time is 3-3.2h, merges lixiviating solution, is concentrated into the 24-25% of original volume, prepares and concentrates
Liquid；
3) Radix Codonopsis pulverized, cross 200 mesh sieves, add the citric acid alcoholic solution of its quality 1.8-2 times, in citric acid alcoholic solution
The mass content of citric acid is 3-4%, heated and stirred 1.8-2h at 58-60 DEG C, then stirring and drying Ji get party at 88-90 DEG C
Ginseng powder；
4) filtrate is mixed with concentrated solution, heated and stirred 35-40min at 72-75 DEG C, be subsequently adding Radix Codonopsis powder, continue
Stirring 18-20min at such a temperature, carry out microwave treatment 6-8min, wherein microwave power is 1000W, then stirs at 84-86 DEG C
Mix drying Chinese medicine preparation.
Another object of the present invention is to provide the application in preparing treating venereal and Dermatology medicine of the described Chinese medicine preparation.
Another object of the present invention is to provide the application in preparation treatment Dermatology medicine of the described Chinese medicine preparation.
Stick grass tonifying the lung；Spleen invigorating；YIN nourishing and the production of body fluid promoting.Cure mainly cough due to deficiency of the lung；Insufficiency of the spleen lack of appetite；Cardiopalmus spontaneous perspiration；Tired out weak；Mouthful
Dry.
The Radix Angelicae Dahuricae gets rid of illness the functions such as dehumidifying, evacuation of pus granulation promoting, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, rhinitis, toothache.Red
Under leucorrhea, bitterly furuncle and phyma poison etc. disease.
Fructus Leonuri has promoting blood flow to regulate menstruation, effect of liver heat removing and eyesight improving.For menoxenia, amenorrhea dysmenorrhea, cataract, dizziness
Distending pain.
Bulbus Allii Macrostemonis activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.Cure mainly obstruction of qi in the chest and cardialgia, gastral cavity abdomen feeling of fullness distending pain, weight after dysentery.
Radix Codonopsis invigorating middle warmer, QI invigorating, promote the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention under the synergism of each raw material, the Chinese medicine preparation prepared have draw out pus by applying a plaster to the affected part, sterilize, antiinflammatory relieves the pain, repair
The curative effect of regeneration, to the Dermatology determined curative effect suffering from sexually transmitted disease (STD) and sexually transmitted disease (STD) causes, cure rate is high, instant effect, has no side effect,
Avoiding various drawbacks and toxic and side effects that Western medicine brings to patient, the present invention is while guaranteeing curative effect, and that tries one's best decreases
The kind quantity of medicine, reduces treatment cost, is suitable for many people and uses.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, the Chinese medicine preparation of a kind for the treatment of venereal and Dermatology, by following former according to weight portion
Material composition: Fructus Leonuri 10 parts, stick grass 16 parts, Bulbus Allii Macrostemonis 22 parts, the Radix Angelicae Dahuricae 20 parts, Radix Codonopsis 1 part.
Stick grass, the Radix Angelicae Dahuricae are pulverized, crossed 100 mesh sieves, adds the sodium bicarbonate aqueous solution of the two quality 10 times, sodium bicarbonate
In aqueous solution, sodium bicarbonate mass content is 5%, and at 50 DEG C, heated and stirred processes 2.5h, then heated and stirred at 72 DEG C
1.5h, then stir process 0.6h at 92 DEG C, cross leaching filtrate.Fructus Leonuri, Bulbus Allii Macrostemonis are pulverized, crossed 80 mesh sieves, adds the two
70% ethanol solution of quality 5 times extracts 2 times, and extraction temperature is 75 DEG C, and extraction time is 32h, merges lixiviating solution, is concentrated into former
The 24% of volume, prepares concentrated solution.Radix Codonopsis is pulverized, crosses 200 mesh sieves, add the citric acid alcoholic solution of its quality 1.8 times, Fructus Citri Limoniae
In acid alcohol solution, the mass content of citric acid is 3%, heated and stirred 1.8h at 58 DEG C, then stirring and drying Ji get party at 88 DEG C
Ginseng powder.Filtrate is mixed with concentrated solution, heated and stirred 35min at 72 DEG C, be subsequently adding Radix Codonopsis powder, continue to stir at such a temperature
Mixing 18min, carry out microwave treatment 6min, wherein microwave power is 1000W, then stirring and drying i.e. obtains Chinese medicine preparation at 84 DEG C.
Embodiment 2
In the embodiment of the present invention, the Chinese medicine preparation of a kind for the treatment of venereal and Dermatology, by following former according to weight portion
Material composition: Fructus Leonuri 18 parts, stick grass 24 parts, Bulbus Allii Macrostemonis 30 parts, the Radix Angelicae Dahuricae 28 parts, Radix Codonopsis 8 parts.
Stick grass, the Radix Angelicae Dahuricae are pulverized, crossed 100 mesh sieves, adds the sodium bicarbonate aqueous solution of the two quality 10 times, sodium bicarbonate
In aqueous solution, sodium bicarbonate mass content is 6%, and at 52 DEG C, heated and stirred processes 2.6h, then heated and stirred at 75 DEG C
1.6h, then stir process 0.8h at 95 DEG C, cross leaching filtrate.Fructus Leonuri, Bulbus Allii Macrostemonis are pulverized, crossed 80 mesh sieves, adds the two
70% ethanol solution of quality 6 times extracts 2 times, and extraction temperature is 78 DEG C, and extraction time is 3.2h, merges lixiviating solution, is concentrated into
The 25% of original volume, prepares concentrated solution.Radix Codonopsis is pulverized, crosses 200 mesh sieves, add the citric acid alcoholic solution of its quality 2 times, Fructus Citri Limoniae
In acid alcohol solution, the mass content of citric acid is 4%, heated and stirred 2h at 60 DEG C, then stirring and drying i.e. obtains Radix Codonopsis at 90 DEG C
Powder.Filtrate is mixed with concentrated solution, heated and stirred 40min at 75 DEG C, be subsequently adding Radix Codonopsis powder, continue to stir at such a temperature
20min, carries out microwave treatment 8min, and wherein microwave power is 1000W, then stirring and drying i.e. obtains Chinese medicine preparation at 86 DEG C.
Embodiment 3
In the embodiment of the present invention, the Chinese medicine preparation of a kind for the treatment of venereal and Dermatology, by following former according to weight portion
Material composition: Fructus Leonuri 12 parts, stick grass 18 parts, Bulbus Allii Macrostemonis 24 parts, the Radix Angelicae Dahuricae 22 parts, Radix Codonopsis 3 parts.
Stick grass, the Radix Angelicae Dahuricae are pulverized, crossed 100 mesh sieves, adds the sodium bicarbonate aqueous solution of the two quality 10 times, sodium bicarbonate
In aqueous solution, sodium bicarbonate mass content is 5.5%, and at 51 DEG C, heated and stirred processes 2.5h, then heated and stirred at 74 DEG C
1.55h, then stir process 0.7h at 93 DEG C, cross leaching filtrate.Fructus Leonuri, Bulbus Allii Macrostemonis are pulverized, crossed 80 mesh sieves, adds the two
70% ethanol solution of quality 5.5 times extracts 2 times, and extraction temperature is 76 DEG C, and extraction time is 3.1h, merges lixiviating solution, concentrates
To the 24.5% of original volume, prepare concentrated solution.Being pulverized by Radix Codonopsis, cross 200 mesh sieves, the Fructus Citri Limoniae acid alcohol adding its quality 1.9 times is molten
Liquid, in citric acid alcoholic solution, the mass content of citric acid is 3.5%, heated and stirred 1.9h at 59 DEG C, then stirs at 89 DEG C
Drying Radix Codonopsis powder.Filtrate is mixed with concentrated solution, heated and stirred 38min at 73 DEG C, be subsequently adding Radix Codonopsis powder, continue
Stirring 19min at a temperature of Gai, carry out microwave treatment 7min, wherein microwave power is 1000W, then stirring and drying and get final product at 85 DEG C
Chinese medicine preparation.
Embodiment 4
In the embodiment of the present invention, the Chinese medicine preparation of a kind for the treatment of venereal and Dermatology, by following former according to weight portion
Material composition: Fructus Leonuri 16 parts, stick grass 22 parts, Bulbus Allii Macrostemonis 28 parts, the Radix Angelicae Dahuricae 26 parts, Radix Codonopsis 6 parts.
Stick grass, the Radix Angelicae Dahuricae are pulverized, crossed 100 mesh sieves, adds the sodium bicarbonate aqueous solution of the two quality 10 times, sodium bicarbonate
In aqueous solution, sodium bicarbonate mass content is 5.5%, and at 51 DEG C, heated and stirred processes 2.5h, then heated and stirred at 74 DEG C
1.55h, then stir process 0.7h at 93 DEG C, cross leaching filtrate.Fructus Leonuri, Bulbus Allii Macrostemonis are pulverized, crossed 80 mesh sieves, adds the two
70% ethanol solution of quality 5.5 times extracts 2 times, and extraction temperature is 76 DEG C, and extraction time is 3.1h, merges lixiviating solution, concentrates
To the 24.5% of original volume, prepare concentrated solution.Being pulverized by Radix Codonopsis, cross 200 mesh sieves, the Fructus Citri Limoniae acid alcohol adding its quality 1.9 times is molten
Liquid, in citric acid alcoholic solution, the mass content of citric acid is 3.5%, heated and stirred 1.9h at 59 DEG C, then stirs at 89 DEG C
Drying Radix Codonopsis powder.Filtrate is mixed with concentrated solution, heated and stirred 38min at 73 DEG C, be subsequently adding Radix Codonopsis powder, continue
Stirring 19min at a temperature of Gai, carry out microwave treatment 7min, wherein microwave power is 1000W, then stirring and drying and get final product at 85 DEG C
Chinese medicine preparation.
Embodiment 5
In the embodiment of the present invention, the Chinese medicine preparation of a kind for the treatment of venereal and Dermatology, by following former according to weight portion
Material composition: Fructus Leonuri 14 parts, stick grass 20 parts, Bulbus Allii Macrostemonis 26 parts, the Radix Angelicae Dahuricae 24 parts, Radix Codonopsis 5 parts.
Stick grass, the Radix Angelicae Dahuricae are pulverized, crossed 100 mesh sieves, adds the sodium bicarbonate aqueous solution of the two quality 10 times, sodium bicarbonate
In aqueous solution, sodium bicarbonate mass content is 5.5%, and at 51 DEG C, heated and stirred processes 2.5h, then heated and stirred at 74 DEG C
1.55h, then stir process 0.7h at 93 DEG C, cross leaching filtrate.Fructus Leonuri, Bulbus Allii Macrostemonis are pulverized, crossed 80 mesh sieves, adds the two
70% ethanol solution of quality 5.5 times extracts 2 times, and extraction temperature is 76 DEG C, and extraction time is 3.1h, merges lixiviating solution, concentrates
To the 24.5% of original volume, prepare concentrated solution.Being pulverized by Radix Codonopsis, cross 200 mesh sieves, the Fructus Citri Limoniae acid alcohol adding its quality 1.9 times is molten
Liquid, in citric acid alcoholic solution, the mass content of citric acid is 3.5%, heated and stirred 1.9h at 59 DEG C, then stirs at 89 DEG C
Drying Radix Codonopsis powder.Filtrate is mixed with concentrated solution, heated and stirred 38min at 73 DEG C, be subsequently adding Radix Codonopsis powder, continue
Stirring 19min at a temperature of Gai, carry out microwave treatment 7min, wherein microwave power is 1000W, then stirring and drying and get final product at 85 DEG C
Chinese medicine preparation.
Comparative example 1
In addition to not containing stick grass, its formula and preparation process are consistent with embodiment 5.
Comparative example 2
Containing only stick grass, its preparation process is consistent with embodiment 5.
Embodiment 6 acute toxicity maximum resistance test
It is maximum resistance to tested that the Chinese medicine preparation that according to embodiments of the present invention prepared by 1-5 carries out acute toxicity at animal skin surfaces
Testing, the day maximum tolerated dose being administered mouse skin coating is 420 times of the clinical consumption per day of adult, does not observes under this dosage
The toxic reaction of the Chinese medicine preparation that the preparation method that the present invention provides is made.
Embodiment 7 long term toxicity test
The Chinese medicine preparation that according to embodiments of the present invention prepared by 1-5 carries out long term toxicity examination in 6 months at animal body skin surface
Test, every day to rat skin coating be administered, dosage be respectively equivalent to adult 100 times of clinic every day day dose, 50 times, 25
Times.Observation item is include General observation and the complete detection that includes including hematological examination 29.Result shows, three administrations
All there is not obvious adverse reaction in dosage, shows that the Chinese medicine preparation that according to embodiments of the present invention prepared by 1-5 for Clinical practice is
Safety.
Embodiment 8 clinical trial
Patient is presented herein below and uses the clinical data of Chinese medicine preparation of the present invention:
One, physical data
Accept patient's totally 400 example for medical treatment, check and be diagnosed as sexually transmitted disease (STD), its age 22-51 year, average 32 years old.It is randomly divided into 8 groups, often
Organize 50 examples, be respectively treatment 1 group, treat 2 groups, treat 3 groups, treat 4 groups, treat 5 groups and comparison 1 group, compare 2 groups, treatment
1-5 group takes the Chinese medicine preparation of embodiment 1-5 respectively, and comparison 1-2 group takes the Chinese medicine preparation of comparative example 1-2 respectively, and usage is used
Amount: once a day, coats surface, affected part.
Two, efficacy assessment standard
Cure: after the course for the treatment of terminates, clinical symptoms is wholly absent.
Take a turn for the better: symptom is alleviated substantially.
Invalid: remission is inconspicuous.
Four, therapeutic outcome
After the drug of topical application 5 days, result is as shown in table 1.
Table 1
| Group | Total number of cases | Cure | Take a turn for the better | Invalid | Cure rate % | Total effective rate % |
| Treat 1 group | 50 | 45 | 5 | 0 | 90 | 100 |
| Treat 2 groups | 50 | 46 | 4 | 0 | 92 | 100 |
| Treat 3 groups | 50 | 49 | 1 | 0 | 98 | 100 |
| Treat 4 groups | 50 | 50 | 0 | 0 | 100 | 100 |
| Treat 5 groups | 50 | 50 | 0 | 0 | 100 | 100 |
| Compare 1 group | 50 | 4 | 20 | 26 | 8 | 48 |
| Compare 2 groups | 50 | 0 | 3 | 47 | 0 | 6 |
Clinical therapeutic efficacy shows, embodiment of the present invention 1-5 is better than compareing 1-3 group, during embodiment of the present invention 1-5 provides
The cure rate of medicine preparation for treating sexually transmitted disease (STD) and Dermatology is more than 90%, and total effective rate is 100%；Wherein embodiment 3-5 is preferable,
Cure rate is more than 98%, and embodiment 4-5 is optimum, and cure rate reaches 100%.Embodiment 5 is compared with comparative example 1-2, it is known that, this
Invention is performance effect under the synergism of each raw material.
Model case:
Zhang, man, 38 years old, as long as the half a year that suffers from venereal disease, red and swollen, fester, agonizing, after implement in the affected part coating present invention
The treatment of example 4 Chinese medicine preparation is clearly better for 3 days, thoroughly recovery from illness in 5 days.
River, man, 42 years old, suffer from venereal disease 3 years as long as, very itch, red and swollen, have ant row sense, coat the embodiment of the present invention 5 in affected part
Chinese medicine preparation treatment takes effect for 2 days, thoroughly recovery from illness in 5 days.
Korea Spro, female, 40 years old, before 3 years, suffered from leukorrhagia, pruritus of vagina, uterine erosion, menstruation black is block, and stink smell is disliked
Smelly.Once treated in multiple hospitals, poor effect.Within 3 days, taking effect in the affected part coating embodiment of the present invention 3 Chinese medicine preparation treatment, 7 days thorough
Fully recover in the end.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter
From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim
Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only wraps
Containing an independent technical scheme, this narrating mode of description is only that for clarity sake those skilled in the art should
Description can also be formed those skilled in the art through appropriately combined as an entirety, the technical scheme in each embodiment
May be appreciated other embodiments.
Claims (6)
1. a treating venereal and the Chinese medicine preparation of Dermatology, it is characterised in that be made up of according to the raw material of weight portion following:
Fructus Leonuri 10-18 part, stick grass 16-24 part, Bulbus Allii Macrostemonis 22-30 part, Radix Angelicae Dahuricae 20-28 part, Radix Codonopsis 1-8 part.
Treating venereal the most according to claim 1 and the Chinese medicine preparation of Dermatology, it is characterised in that by following according to weight
The raw material composition of amount part: Fructus Leonuri 12-16 part, stick grass 18-22 part, Bulbus Allii Macrostemonis 24-28 part, Radix Angelicae Dahuricae 22-26 part, Radix Codonopsis 3-6 part.
Treating venereal the most according to claim 1 and the Chinese medicine preparation of Dermatology, it is characterised in that by following according to weight
The raw material composition of amount part: Fructus Leonuri 14 parts, stick grass 20 parts, Bulbus Allii Macrostemonis 26 parts, the Radix Angelicae Dahuricae 24 parts, Radix Codonopsis 5 parts.
4. a preparation method for the Chinese medicine preparation of the treating venereal as described in claim 1-3 is arbitrary and Dermatology, it is special
Levy and be, comprise the steps of:
1) stick grass, the Radix Angelicae Dahuricae are pulverized, crossed 100 mesh sieves, add the sodium bicarbonate aqueous solution of the two quality 10 times, sodium bicarbonate water
In solution, sodium bicarbonate mass content is 5-6%, and at 50-52 DEG C, heated and stirred processes 2.5-2.6h, then adds at 72-75 DEG C
Thermal agitation 1.5-1.6h, then stir process 0.6-0.8h at 92-95 DEG C, cross leaching filtrate；
2) Fructus Leonuri, Bulbus Allii Macrostemonis being pulverized, cross 80 mesh sieves, 70% ethanol solution adding the two quality 5-6 times extracts 2 times, extraction
Temperature is 75-78 DEG C, and extraction time is 3-3.2h, merges lixiviating solution, is concentrated into the 24-25% of original volume, prepares concentrated solution；
3) Radix Codonopsis pulverized, cross 200 mesh sieves, add the citric acid alcoholic solution of its quality 1.8-2 times, Fructus Citri Limoniae in citric acid alcoholic solution
The mass content of acid is 3-4%, heated and stirred 1.8-2h at 58-60 DEG C, then stirring and drying i.e. obtains Radix Codonopsis at 88-90 DEG C
Powder；
4) filtrate is mixed with concentrated solution, heated and stirred 35-40min at 72-75 DEG C, be subsequently adding Radix Codonopsis powder, continue at this
At a temperature of stir 18-20min, carry out microwave treatment 6-8min, wherein microwave power is 1000W, then at 84-86 DEG C stirring dry
Do and i.e. obtain Chinese medicine preparation.
5. the application in preparing treating venereal medicine of the Chinese medicine preparation as described in claim 1-3 is arbitrary.
6. the application in preparation treatment Dermatology medicine of the Chinese medicine preparation as described in claim 1-3 is arbitrary.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167841A (en) * | 2007-11-14 | 2008-04-30 | 胡启栋 | Medicine for curing venereal disease and inflammation |
| CN102727639A (en) * | 2012-07-03 | 2012-10-17 | 许瑞琴 | External-use medicine for treating venereal disease |
| CN105998579A (en) * | 2016-07-25 | 2016-10-12 | 湖南中医药大学 | Medicine for treating infertility caused by salpingitis as well as preparation method and application thereof |
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2016
- 2016-07-22 CN CN201610585715.7A patent/CN106109867A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167841A (en) * | 2007-11-14 | 2008-04-30 | 胡启栋 | Medicine for curing venereal disease and inflammation |
| CN102727639A (en) * | 2012-07-03 | 2012-10-17 | 许瑞琴 | External-use medicine for treating venereal disease |
| CN105998579A (en) * | 2016-07-25 | 2016-10-12 | 湖南中医药大学 | Medicine for treating infertility caused by salpingitis as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张廷模: "《临床中药学》", 31 March 2009, 上海科学技术出版社 * |
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Application publication date: 20161116 |